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Книги з теми "Kinase Syk"

Автор: Grafiati

Опубліковано: 29 березня 2025

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1

Chen, Linyun. Exploring the structure and functions of Sak, a gene encoding a serine/threonine kinase. Ottawa: National Library of Canada, 1996.

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2

Senin, Viktor. Syn faraona: [fantasticheskai︠a︡ povestʹ]. Sankt-Peterburg: Amfora, 2006.

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3

Thom, James Alexander. Panther in the sky. New York: Ballantine Books, 1990.

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4

Thom, James Alexander. Panther in the sky: A Novel. New York: Ballantine Books, 1989.

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5

Kanbe, Mamoru. Sora no woto: Sound of the sky. Hackensack, NJ: Bayview Entertainment, 2013.

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6

Nowacki, Bronisław. Przemysł I: Syn Władysława Odonica, książę wielkopolski, 1220/1221-1257. Poznań: Wydawn. WBP, 2003.

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7

Miller, Linda Lael. Big Sky River: The Parable (Big Sky) series. 2nd ed. Don Mills, Canada: Harlequin HQN, 2012.

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8

Kim, Sang-hŏn. Tongnye suchʻo. Ŭirye munhae sok. Kogŭm sangnye idongŭi. Pusan Kwangyŏksi: Minjok Munhwa, 2008.

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9

Golightly, Walton. AmaZulu: Being the many divers adventures of the Induna & the boy among the People of the Sky in the time of Shaka kaSenzangakhona, King of Kings. Cape Town: Kwela Books, 2007.

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10

Fleischmann, Roy. Signalling pathway inhibitors. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0081.

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Анотація:

Oral, small-molecule signalling pathway inhibitors, including ones that inhibit the JAK and SyK pathways, are currently in development for the treatment of rheumatoid arthritis (RA). Tofacitinib is an orally administered small-molecule inhibitor that targets the intracellular Janus kinase 3 and 1 (JAK1/3) molecules to a greater extent than JAK2 while baricitinib (formerly INCB028050) predominantly inhibits JAK1/2. Many of the proinflammatory cytokines implicated in the pathogenesis of RA utilize cell signalling that involves the JAK-STAT pathways and therefore inhibition of JAK-STAT signalling, by targeting multiple RA-associated cytokine pathways, has the potential to simultaneously reduce inflammation, cellular activation, and proliferation of key immune cells. Fostamatinib disodium is an orally available inhibitor of spleen tyrosine kinase (SyK), which is a cytoplasmic tyrosine kinase that is an important mediator of immunoreceptor signalling in mast cells, macrophages, neutrophils, and B cells. Interruption of SyK signalling may interrupt production of tumour necrosis factor (TNF) and metalloproteinase and therefore affect RA disease activity. Tofacitinib has been investigated in multiple phase 2 and phase 3 trials which have investigated its efficacy (clinical, functional, and radiographic) and safety in patients who have failed disease-modifying anti-inflammatory drugs (DMARDs) as monotherapy or in combination with DMARDs, compared to an inhibitor of tumour necrosis factor alpha (TNFα‎) and in patients who have failed TNFα‎ inhibitors. The efficacy of fostamatinib and baricitinib has been investigated in phase 2 trials; both are in large phase 3 clinical programmes. Each of these medications has demonstrated efficacy; their safety profile has been shown to be different from each other and from currently approved biological agents. This chapter discusses what is currently known and understood about their efficacy and safety.

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11

Hussain, Azeemudeen. The role of Serum and Glucocorticoid-inducible Kinase 1 (sGK 1 ) in cardiac fibrosis and intestinal transport-Characterisation of novel substrates. 2006.

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12

Thom, James Alexander. Panther in the Sky. Tandem Library, 1999.

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13

Burning Sky. Balzer and Bray, 2013.

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14

Thomas, Sherry. Burning Sky. HarperCollins Publishers, 2014.

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15

Thomas, Sherry. Burning Sky. HarperCollins Publishers, 2014.

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16

Thomas, Sherry. Burning Sky. HarperCollins Publishers, 2013.

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17

Thomas, Sherry. Burning Sky. HarperCollins Publishers, 2014.

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18

Thom, James Alexander. Panther in the Sky. Ballantine Books, 1995.

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19

Thom, James Alexander. Panther in the Sky. Random House Value Publishing, 1991.

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20

Golightly, Walton. The People of the Sky (Zulu Saga). Quercus, 2013.

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21

Przemys I: Syn Wadysawa Odonica, Ksiaze Wielkopolski 1220/1221-1257. Wydawn. Wojewodzkiej Biblioteki Publicznej, 2003.

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22

Neofit︠s︡ialʹnai︠a︡ istorii︠a︡ Rossii: Otet︠s︡ i syn : Nikolaĭ I i Aleksandr II. Moskva: OLMA Mediagrupp, 2007.

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23

Ilbon yŏksa sok Paekche wangson: Imsŏng Wangja huson iyagi. Sŏul T'ŭkpyŏlsi: Koraesil, 2008.

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24

Taylor, Amie. The Big Book of LGBTQ+ Activities. Jessica Kingsley Publishers, 2020. http://dx.doi.org/10.5040/9781805015512.

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Анотація:

With 5 fun tales featuring merpeople, a rainbow wedding and a back-to-front horse, this captivating guide to LGBTQ+ identities takes you on a journey through Clear Sky Castle to promote inclusion for children aged 6 to 9. The interactive stories and games - including drawing, sculpting, word searches and quizzes - raise awareness of different kinds of families, as well as identities such as gay, lesbian, bisexual, transgender and non-binary, and teach acceptance for all. The resourceful 'Guide for Adults' at the end of the book offers advice, answers to activities throughout, and signposts to helpful organisations for the adult reading the book with the child.

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25

Beyond: Broken Sky Chronicles, Book 3. Turner, 2017.

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26

Iyagi sik ŭro kusŏng han Ijo 500-yŏn: Wanggung ŭi hyŏlchŏn kwa yŏindŭl ŭi t'ŭkchong pisa. Sŏul: Pŏmmun Puksŭ, 2020.

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27

Yongp'o sok ŭi pimil, mich'idorok karyŏptoda: Sŭngjŏngwŏn ilgi esŏ ch'aja naen Chosŏn wangdŭl ŭi karyŏum. Sŏul-si: Sidae ŭi Ch'ang, 2015.

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28

Grimm, Jacob and Wilhelm. Selected Tales. Translated by Joyce Crick. Oxford University Press, 2009. http://dx.doi.org/10.1093/owc/9780199555581.001.0001.

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Анотація:

‘Once upon a time in mid-winter, when the snowflakes were falling from the sky like down, a queen was sitting and sewing at a window ...’The tales gathered by the Grimm brothers are at once familiar, fantastic, homely, and frightening. They seem to belong to no time, or to some distant feudal age of fairytale imagining. Grand palaces, humble cottages, and the forest full of menace are their settings; and they are peopled by kings and princesses, witches and robbers, millers and golden birds, stepmothers and talking frogs. Regarded from their inception both as uncosy nursery stories and as raw material for the folklorist the tales were in fact compositions, collected from literate tellers and shaped into a distinctive kind of literature. This translation mirrors the apparent artlessness of the Grimms, and fully represents the range of less well-known fables, morality tales, and comic stories as well as the classic tales. It takes the stories back to their roots in German Romanticism and includes variant stories and tales that were deemed unsuitable for children. In her fascinating introduction, Joyce Crick explores their origins, and their literary evolution at the hands of the Grimms.‘

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29

Wang, Aihe. Moral Rulership and World Order in Ancient Chinese Cosmology. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199670055.003.0012.

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Анотація:

This chapter primarily focuses on the contrast between the ‘blue-sky’ serene world of classical Confucian ethics and the vulnerability of the Confucian scholar in a power structure rooted in a conquering warrior absolute monarchy. It further provides an exhaustive and authoritative history of Confucianism within the history of China and thoroughly reinforces criticisms of Confucianism in contrast to the Dao. The chapter portrays how the concept of the Mandate of Heaven was always used by military conquerors to provide legitimacy for their use of force. As Confucianism became the official ideology of the State during the time of Emperor Wu (141–87 BC), a very sharp contrast arose between the Confucian ideology represented by Dong Zhonshu (the time of Emperor Wu) and the Dao-oriented thinking of the King of Huainan. The former represented an authoritarian institution of centralization and hierarchy, with the Confucian scholar class claiming to interpret a moral cosmology to strengthen the authority of the emperor, and, by implication, that of his scholar advisers. Their task was to interpret the will of ‘an anthropomorphic deity from Zhou theology, attributing to it a heart, intention and love. Heaven manifests his will in omens … as Heaven’s speech’. Only the sage Confucius could understand and interpret the moral consciousness of Heaven. Their recommendation was for wholesale centralization of culture, political, military, and economic. At the same time, the Chinese Empire was in constant military expansion in all directions. It concluded with a recommendation for the conquest and execution of the Huainan kings, among others, as representatives of the anti-hierarchical Daoism. As Wang puts it, ‘the ideological unification was essential for building an authoritarian and centralized imperial order. By suppressing different cultural and philosophical traditions, it established universal rules and standards that were themselves the web of the centralized empire.

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30

Ilbon munhŏn sok ŭi Yi Sun-sin p'yosang: The image of Yi Sun-sin in Japanese literature. Sŏul: Minsogwŏn, 2022.

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