Статті в журналах: "Ischemic pathology of heart"

1

Pulyaeva, I. S. "RESULTS OF INSPECTION AND TREATMENT OF PATIENTS WITH STENOSIS OF CAROTIDS IN COMBINATION WITH PATHOLOGIES OF OTHER SYSTEMS." Kharkiv Surgical School, no. 5-6 (December 25, 2019): 99–103. http://dx.doi.org/10.37699/2308-7005.5-6.2019.21.

Повний текст джерела

Анотація:

Summary. An aim of work is an analysis of results of inspection and treatment of patients with the hemodynamically meaningful defeat of carotids in combination with pathology of other organs and systems. Materials and methods. The results of treatment are analysed 187 patients with hemodynamically by meaningful stenosis of carotids in SI «Zaycev V.T. IGUS of NAMSU» from 2015 for 2018 on a background forthcoming surgical treatment of chronic ischemia of lower limbs, ischemic heart or pathology of gastrointestinal tract trouble. Patients are divided into 3 groups. The first group was made by patients with the chronic ischemia of lower limbs of 2-Д degree - 167 patients. 7 patients entered a group with pathology of gastrointestinal tract. 3 a group was made by 13 patients with ischemic heart trouble. Results and discussion. The direct results of operation we estimated complex on the basis of degree of change of clinical status and presence of postoperative complications. At 161 the patients of the first group in a postoperative period are not educed complications, for a 2th patient thrombosis of anastamosis and ischemic stroke, at 4th paresis of n. Hypoglossuss. In the second group for all operated patients concerning stenosis of carotid, complications were not in a postoperative period. For one patient with the cancer of stomach, that was not execute a reconstructive operation on a carotid an ischemic stroke developed in connection with bleeding. In 3 cases in a postoperative period observed symptomatology of stroke for patients operated concerning ischemic heart, carotid endarterectomia was not executed these patients. Conclusions. To the patients with general atherosclerosis and stroke in anamnesis it is necessary to conduct carotids screening. At hemodynamically meaningful stenosises patients with heart diseaseby and pathology of abdomen of must execute carotid endarterectomia of the first stage, that reduces the risk of ischemic stroke in a postoperative period at treatment of basic pathology.

Стилі APA, Harvard, Vancouver, ISO та ін.

2

Iqbal, Sohail. "Cardiovascular Magnetic Resonance in Ischemic Heart Disease." European Journal of Medical and Health Sciences 3, no. 4 (July 5, 2021): 11–12. http://dx.doi.org/10.24018/ejmed.2021.3.4.927.

Повний текст джерела

Анотація:

Ischemic heart disease is one of the leading causes of death and disability, limiting individual’s quality of life. Cardiac magnetic resonance is radiation-free tool to image IHD patients and can depict inducible ischemia, extent and distribution of scar burden, associated complications like mitral regurgitation, thrombus, aneurysm formation, myocardial rupture, and any other incidental pathology. With increasing availability of the CMR there is an ever increasing need to interpret these images by non-imaging clinicians in order to manage patients more effectively. In this article, image interpretation for detection of ischemia, infarct and thrombus are discussed in simple easy to understand manner leaving behind intricate technical details which are of less important to the referring physicians.

Стилі APA, Harvard, Vancouver, ISO та ін.

3

Frolov, M. A., N. A. Sakhovskaya, A. M. Frolov, and A. D. Pryamikov. "Feature of Ocular-Ischemic Syndrome in Patients with Cardiovascular Pathology. Literature Review." Ophthalmology in Russia 17, no. 2 (June 23, 2020): 188–94. http://dx.doi.org/10.18008/1816-5095-2020-2-188-194.

Повний текст джерела

Анотація:

Vascular pathology of the vision organ is one of the leading causes of irreversible vision loss. Ocular ischemic syndrome is a serious condition that requires special attention to prevent adverse effects and outcomes. Today, this syndrome mainly occurs in the form of ischemic optic neuropathy and chronic ischemic retinopathy, which are based on damage caused by impaired perfusion in the pool of the ophthalmic artery. According to the data presented in foreign and domestic literature, there is an correlation between the ocular ischemic syndrome and the pathology of the cardiovascular system. Often, this pathology is accompanied by such diseases as: coronary heart disease, atherosclerosis, arterial hypertension, and diabetes mellitus. A number of studies have shown that an important risk factor for the development of vascular eye’s pathology is the combination of coronary heart disease with elevated total blood cholesterol and atherosclerosis in combination with arterial hypertension. Also, there are data indicating the association of the risk of ischemic opticopathy with the presence of cardiovascular diseases in patients, and vice versa, previously transferred opticopathy can be considered as predictors of cardiovascular pathology. Thus, prevention and treatment of this pathology is an interdisciplinary problem. The classical approach in the treatment of ocular ischemic syndrome today remains conservative therapy, which aims to reduce local ischemia and the effects of hypoxia. However, conservative treatment does not eliminate the main reason for the development of this condition; therefore, the search continues for new, more effective methods of preventing and treating this pathology. In recent years, data on high clinical efficacy in the treatment and prevention of ocular ischemic syndrome manifestations have appeared in the literature after surgery to restore the main blood flow at the level of the brachiocephalic arteries. A variety of cardiovascular diseases and various levels of its damage determine the approach to the treatment of this pathology. This literature review is devoted to the analysis of the causes of ocular ischemic syndrome, depending on the level of localization of the lesion of the cardiovascular system.

Стилі APA, Harvard, Vancouver, ISO та ін.

4

Aretz, H. Thomas. "Nenstherscloerotic Ischemic Heart Disease." American Journal of Surgical Pathology 14, no. 4 (April 1990): 402. http://dx.doi.org/10.1097/00000478-199004000-00019.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

5

Morales, Azorides R. "Non-atherosclerotic ischemic heart disease." Human Pathology 21, no. 1 (January 1990): 124. http://dx.doi.org/10.1016/0046-8177(90)90091-i.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

6

Andonieva, N. M., E. A. Huts, М. Ya Dubovik, S. A. Olyanich, and L. V. Mykhailiuk. "CARDIOVASCULAR PATHOLOGY AS AN IMPORTANT SOCIAL PROBLEM IN PATIENTS WITH CKD." Experimental and Clinical Medicine 86, no. 1 (March 31, 2020): 58–64. http://dx.doi.org/10.35339/ekm.2020.86.01.08.

Повний текст джерела

Анотація:

A study of 114 patients who received renal replacement therapy by peritoneal dialysis, whose average age was (47.9±1.2) years, the duration of dialysis therapy - (53.0±2.3) months. EchoCG results with Doppler, bicycle ergometric loading ECG tests are analyzed in dynamics. Depending on the detected changes, patients were divided into five clinical groups. The first group included patients who suffered an acute myocardial infarction during the study. To the second - patients with stable angina. To the third - patients with painless myocardial ischemia. The fourth group included patients with ischemic dilated cardiomyopathy (IDCMP). Fifth - the comparison group, which included patients without signs of coronary heart disease. Patients were determined biochemical parameters of phosphorus-calcium, lipid metabolism, proinflammatory interleukins (TNF-a, IL-1ß, IL-8), C-reactive protein and CAA protein. It was found that cardiorenal syndrome in patients with chronic kidney disease on peritoneal dialysis leads to the progression of coronary heart disease. The formation of different clinical variants of coronary heart disease in such patients is multifactorial, initiated by impaired lipid metabolism with subsequent immunological changes in combination with the processes of remodeling of the left ventricular myocardium, calcification and fibrosis of the aorta, cardiac structures and heart valves. Proinflammatory interleukins TNF-a, IL-1ß, and C-reactive protein are most likely predictors of acute myocardial infarction, whereas IL-8 and acute inflammatory protein (serum amyloid) are associated with ischemic dilated cardiomyopathy, in patients with chronic kidney disease on peritoneal dialysis. Keywords: renocardial syndrome, renal replacement therapy, peritoneal dialysis, coronary heart disease, heart failure.

Стилі APA, Harvard, Vancouver, ISO та ін.

7

Dzhaiani, N. A. "CANDESARTAN IN CARDIOLOGY PRACTICE." Medical Council, no. 7 (December 30, 2017): 12–16. http://dx.doi.org/10.21518/2079-701x-2017-7-12-16.

Повний текст джерела

Анотація:

The most significant risk factor for the development of cardiovascular diseases such as myocardial infarction, ischemic heart disease, chronic heart failure, is arterial hypertension (AH). [1] AH also contributes to the development of cerebrovascular pathology (ischemic or hemorrhagic stroke, transient ischemic attack) and kidney diseases (chronic kidney disease).

Стилі APA, Harvard, Vancouver, ISO та ін.

8

Majetschak, Matthias. "Regulation of the proteasome by ATP: implications for ischemic myocardial injury and donor heart preservation." American Journal of Physiology-Heart and Circulatory Physiology 305, no. 3 (August 1, 2013): H267—H278. http://dx.doi.org/10.1152/ajpheart.00206.2012.

Повний текст джерела

Анотація:

Several lines of evidence suggest that proteasomes are involved in multiple aspects of myocardial physiology and pathology, including myocardial ischemia-reperfusion injury. It is well established that the 26S proteasome is an ATP-dependent enzyme and that ischemic heart disease is associated with changes in the ATP content of the cardiomyocyte. A functional link between the 26S proteasome, myocardial ATP concentrations, and ischemic cardiac injury, however, has been suggested only recently. This review discusses the currently available data on the pathophysiological role of the cardiac proteasome during ischemia and reperfusion in the context of the cellular ATP content. Depletion of the myocardial ATP content during ischemia appears to activate the 26S proteasome via direct regulatory effects of ATP on 26S proteasome stability and activity. This implies pathological degradation of target proteins by the proteasome and could provide a pathophysiological basis for beneficial effects of proteasome inhibitors in various models of myocardial ischemia. In contrast to that in the ischemic heart, reduced and impaired proteasome activity is detectable in the postischemic heart. The paradoxical findings that proteasome inhibitors showed beneficial effects when administered during reperfusion in some studies could be explained by their anti-inflammatory and immune suppressive actions, leading to reduction of leukocyte-mediated myocardial reperfusion injury. The direct regulatory effects of ATP on the 26S proteasome have implications for the understanding of the contribution of the 26S proteasome to the pathophysiology of the ischemic heart and its possible role as a therapeutic target.

Стилі APA, Harvard, Vancouver, ISO та ін.

9

Rodríguez-Calvo, M. S., M. N. Tourret, L. Concheiro, J. I. Muñoz, and J. M. Suárez-Peñaranda. "Detection of Apoptosis in Ischemic Heart." American Journal of Forensic Medicine and Pathology 22, no. 3 (September 2001): 278–84. http://dx.doi.org/10.1097/00000433-200109000-00016.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

10

Kaplunova, V. Y., G. A. SHakaryants, M. V. Kozhevnikova, I. S. Ilgisonis, E. V. Privalova, N. V. Khabarova, Y. I. Naymann, Y. N. Belenkov, and V. A. Shakaryants. "Hypertrophic Cardiomyopathy and Ischemic Heart Disease. Variants of Combination Pathology." Kardiologiia 17, no. 12 (2017): 16–24. http://dx.doi.org/10.18087/cardio.2017.12.10062.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

11

Burtovaia, E., T. Kantina, and E. Litvinchuk. "Long-Term Mental Disorders in the Accident-Exposed Population of the Southern Urals." Medical Radiology and radiation safety 65, no. 4 (November 1, 2020): 22–28. http://dx.doi.org/10.12737/1024-6177-2020-65-4-22-28.

Повний текст джерела

Анотація:

Purpose: To study late mental and behavioral disorders (ICD-10) in individuals who were accidentally exposed in the Southern Urals. Material and methods: The research subjects are the persons who were exposed to radiation as a result of dumping of radioactive waste into the Techa River (1949–1956), who were born before 1953 and lived in the Techa River basin between 1950 and 1960. The study group consists of 425 people, women predominate (72.5 %), people with secondary special education make up 44.5 %, and pensioners amount to 89.4 %. Mean age at examination was 67.3 ± 5.3 years. Information on radiation doses included data on the absorbed dose to the stomach, which was considered as an analog of brain exposure (50 ± 3 mGy). The paper uses clinical-anamnestic, clinical-psychopathological, clinical and instrumental methods. Results: It has been demonstrated that in the long-term period, accidentally exposed individuals have organic nonpsychotic mental disorders (72.2 %), with the predominance of organic asthenic (29.6 %) and organic cognitive (36.5 %) disorders. Among the studied individuals, only 20.9 % showed no signs of mental illness. Higher absorbed doses to the stomach (70 ± 8 mGy, p = 0.01) was determined in patients with organic cognitive disorder. Concomitant somatic pathology is present in patients with organic cognitive disorder — hypertension (90.3 %, p = 0.005), ischemic heart disease (56.7, p = 0.004), chronic brain ischemia (43.2 %, p = 0.04). Patients with organic asthenic disorder may have hypertension (94.4 %, p = 0.0002), ischemic heart disease (51.6 %, p = 0.04), chronic brain ischemia (35.7 %, p = 0.02). In the group of patients without mental pathology, the most common were hypertension (76.4 %), diseases of the musculoskeletal system (61.7 %, p = 0.03), and ischemic heart disease (37.1 %). Multiple correlation analysis showed a weak statistically significant association of organic mental disorders with chronic brain ischemia, hypertension, ischemic heart disease and the age of patients. Conclusion: The performed study complements the current understanding of long-term mental disorders in exposed individuals, and requires further research to study the pathogenesis of cerebrovascular and cardiovascular diseases in individuals exposed to radiation.

Стилі APA, Harvard, Vancouver, ISO та ін.

12

Burkauskienė, Aušra, Vidmantas Aželis, Žibuoklė Senikienė, Vitas Linonis, and Irina Ramanauskienė. "The structure of myocardial nerve plexus of human auricle of the right atrium and its relation to myocardial ischemia, functional status of the heart, and age." Medicina 44, no. 1 (January 13, 2008): 40. http://dx.doi.org/10.3390/medicina44010007.

Повний текст джерела

Анотація:

The aim of this study was to investigate and evaluate morphometrically the relationship between changes in the structure of myocardial nerve plexus of the right atrium auricle and myocardial ischemia, parameters reflecting functional status of the heart, and age. A total of 56 females and males aged 20–94 years were investigated. Ischemic heart disease group consisted of 39 persons (their mean age was 63.83±15.67 years). The control group comprised 17 persons (the mean age was 60.53±9.89 years). Control group consisted of deceased persons who according to the pathologic and anatomic examination were not diagnosed with cardiac pathology leading to heart lesions or overload. Ischemic heart disease group consisted of patients who underwent aorta-coronary artery bypass grafting surgery. In ischemic heart disease group, degree of coronary artery stenosis was evaluated as well as the major indicators reflecting the size of atria and formation of postinfarction scar. After examination, postinfarction scars were found in 18 (46.2%) persons; no scars were found in 21 (53.8%) persons. Neurohistochemical method and video microscopy were employed for the evaluation of quantitative changes in the structure of the myocardial nerve plexus. In ischemic heart disease group, the structures of nerve plexus occupied 5.0±1.0% of the area, perimeter was 10 488±2134 mm, and number of the structures was 2698±981; the same parameters in the control group were 6.0±1.4%, 13 008±443 mm, and 3469±1511, respectively. In persons with postinfarction scar, the number of nerve plexus structures was lower by 9.3%, area by 8.9%, perimeter by 9.7% on average as compared to ischemic heart disease group without a scar. Regression analysis did not reveal any statistically significant correlation between the degree of coronary artery stenosis and quantitive parameters of nerve plexus (P>0.05). Changes in quantitative parameters of nerve plexus were not related to compensatory dilation of the atria – echoscopy parameters of long and short axes. The results showed that the number, area, and perimeter of nerve plexus structures decreases at the same rate both in healthy subjects and patients with ischemic heart disease starting the fifth decade of life.

Стилі APA, Harvard, Vancouver, ISO та ін.

13

Bolea Batar, Florina, Gabriela Eminovici, Andra-Maria Bebeselea, and Ioan Manitiu. "Multimodality Imaging in Ischemic Cardiomyopathy." Acta Universitatis Cibiniensis. Technical Series 71, no. 1 (December 1, 2019): 1–4. http://dx.doi.org/10.2478/aucts-2019-0001.

Повний текст джерела

Анотація:

Abstract Ischemic heart disease is the most common heart pathology in medical practice. Proper assessment of the size of myocardium injury and its consequences on the heart function is extremely important both for a correct drug therapy and for interventional approach. Most frequently the left ventricle is affected. The need for accurate evaluation of the impact of left ventricular myocardial damage has led to the development of new imaging techniques and improvement of the existing ones. At the moment the most commonly used imaging method for the assessment of left ventricular function is echocardiography. Cardiac Magnetic Resonance and nuclear tomography are precious imaging techniques as well. They are more expensive but bring valuable information when used in adequate situations.

Стилі APA, Harvard, Vancouver, ISO та ін.

14

Szabó, Evelin, Zsolt Parajkó, Diana Opincariu, Monica Chițu, Nóra Raț, and Imre Benedek. "A Genomic Approach to Characterize the Vulnerable Patient – a Clinical Update." Journal of Interdisciplinary Medicine 4, no. 3 (September 1, 2019): 141–44. http://dx.doi.org/10.2478/jim-2019-0023.

Повний текст джерела

Анотація:

Abstract Atherosclerosis is the elemental precondition for any cardiovascular disease and the predominant cause of ischemic heart disease that often leads to myocardial infarction. Systemic risk factors play an important role in the starting and progression of atherosclerosis. The complexity of the disease is caused by its multifactorial origin. Besides the traditional risk factors, genetic predisposition is also a strong risk factor. Many studies have intensively researched cardioprotective drugs, which can relieve myocardial ischemia and reperfusion injury, thereby reducing infarct size. A better understanding of abnormal epigenetic pathways in the myocardial pathology may result in new treatment options. Individualized therapy based on genome sequencing is important for an effective future medical treatment. Studies based on multiomics help to better understand the pathophysiological mechanism of several diseases at a molecular level. Epigenomic, transcriptomic, proteomic, and metabolomic research may be essential in detecting the pathological phenotype of myocardial ischemia and ischemic heart failure.

Стилі APA, Harvard, Vancouver, ISO та ін.

15

Kovalevskaya, E. A., N. S. Krylova, and N. G. Poteshkina. "Hypertrophic cardiomyopathy and ischemic heart disease: the problem of pathology combination." Kardiologiia 17, S1 (2018): 31–35. http://dx.doi.org/10.18087/cardio.2386.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

16

Eremin, Andrey V., A. V. Lepilin, T. E. Lipatova, and I. M. Kvetnoy. "Chronic periodontitis and ischemic heart disease: morphofunctional relation-ships." Russian Journal of Dentistry 24, no. 4 (December 16, 2020): 219–24. http://dx.doi.org/10.17816/1728-2802-2020-24-4-219-224.

Повний текст джерела

Анотація:

The relationship between periodontal diseases and cardiovascular pathology is actively being studied. The clinical significance of tissue markers of endothelial dysfunction in acute or chronic periodontitis needs to be clarified. Materials and methods. The results of the examination of 65 patients with chronic generalized periodontitis (CP), 35 patients with chronic coronary heart disease (CHD), and 35 patients with combined pathology including CHD and CP were presented. Clinical instrumental examination, assessment of the functional state of the endothelium, immunohistochemical, and morphometric studies were performed. Results. Patients with moderate CP were characterized by functional changes in the endothelium, decreased expression of the vasodilating factor (e-NO-synthase), and endothelial progenitor cells (CD34+cells) in the vascular wall. In patients with CHD without periodontitis, there was also a decrease in the expression and optical density of endothelial NO-synthase and endothelial progenitor cell in the periodontal vessels. Conclusion. Apparently, changes in the expression of endothelial NO-synthase and endothelial progenitor cells (CD34+cells) in the vascular wall are generalized, and the gum can serve as a promising material for the early assessment of endothelial dysfunction.

Стилі APA, Harvard, Vancouver, ISO та ін.

17

Izquierdo-Blasco, Jaume, María Teresa Salcedo Allende, Maria Gemma Codina Grau, Ferran Gran, Elena Martínez Sáez, and Joan Balcells. "Parvovirus B19 Myocarditis: Looking Beyond the Heart." Pediatric and Developmental Pathology 23, no. 2 (July 23, 2019): 158–62. http://dx.doi.org/10.1177/1093526619865641.

Повний текст джерела

Анотація:

Human parvovirus B19 represents the most common etiology of myocarditis in the pediatric population. Although it usually causes a benign exanthematic viral infection, parvovirus B19 may also present as disseminated disease with tropism for the myocardium, causing heart failure with high mortality. We present the case of a 2-year-old patient with fulminating acute myocarditis in whom the histological, immunophenotypic, and microbiological findings in necropsy showed multiorgan involvement caused by parvovirus B19. The autopsy revealed changes due to infection with parvovirus B19 as well as hypoxic-ischemic and secondary autoimmune changes. Medullary aplasia was observed, transmural lymphocyte myocarditis, lymphocytosis in the dermis with endothelial cells positive for parvovirus B19 in immunohistochemistry, cholestatic hepatitis due to ischemia and autoimmune hepatitis, lymphadenitis, and signs of hemophagocytosis. We also found hypoxic-ischemic encephalopathy.

Стилі APA, Harvard, Vancouver, ISO та ін.

18

Chukaeva, I. I., N. V. Orlova, and M. V. Soloveva. "Rational therapy of hypertension with concomitant ischemic heart disease." Systemic Hypertension 11, no. 1 (March 15, 2014): 29–33. http://dx.doi.org/10.26442/sg29004.

Повний текст джерела

Анотація:

Hypertension is one of the most common cardiovascular diseases, that causes the disability and mortality. Recommendations of the European Society of Hypertension and the European Society of Cardiologyin 2013 identified new approaches of antihypertensive therapy. For the control of blood pressure is recommended five major groups of drugs. Numerous multicenter studies confirm the high efficiency of angiotensin converting enzyme inhibitors (perindopril) and calcium antagonists (amlodipine). Drugs have proven marked hypotensive and cardioprotective effects. Prestarium fixed combination with a calcium antagonist such as amlodipine (Prestancia) due to the synergistic effect allows for greater efficiency and can be recommended in the treatment of combined pathology of hypertension and coronary heart disease.

Стилі APA, Harvard, Vancouver, ISO та ін.

19

Semeniv, Petro M. "The Influence of Operation Duration and Ischemic Time of Artificial Circulation on the Structure of Postoperative Complications in Patients after Surgical Treatment of Multivalvular Defects Combined with Coronary Pathology." Ukrainian Journal of Cardiovascular Surgery 30, no. 1 (46) (March 23, 2022): 15–20. http://dx.doi.org/10.30702/ujcvs/22.30(01)/s008-1520.

Повний текст джерела

Анотація:

The aim. To determinate the influence of the duration of artificial circulation and ischemic time on the structure of complications with one-time combined correction of lesions of two or three heart valves and myocardial revascularization and the possibility of their avoidance. Materials and methods. The work is based on a comparative analysis of the results of one-step multivalvular correction combined with coronary artery bypass grafting (CABG) in 93 patients, which was performed at the National Amosov Institute of Cardiovascular Surgery from 2014 to 2021. Depending on the tactical approaches and the sequence of surgical manipulations, the patients were divided into three groups. Group I included patients who underwent heart valve correction first and then CABG with the use of cardioplegia (n = 42), group II patients underwent CABG first and then valve correction with the use of cardioplegia (n = 36), and group III patients underwent off-pump CABG first and then correction of the heart valves (n = 15). The groups differed significantly in terms of ischemic time and artificial circulation. Results. The use of different approaches to achieve high-quality protection of the myocardium during ischemia and to minimize the impact of artificial circulation on the body by improving conditions and reducing ischemic time in the correction of multivalvular lesions and CABG showed significant advantages of the method of off-pump bypass. Conclusions. Correction of combined valvular and coronary pathology in patients with cardioplegic arrest increases the ischemic time above the critical point, which affects the occurrence of specific complications, especially acute heart failure, which significantly worsens the immediate results of surgery. Complications that occurred in the postoperative period in patients with the correction of valvular defects combined with CABG were due to prolonged cardiovascular failure. The technique proposed in the study group with off-pump bypass surgery was more effective than in groups where bypass was performed with the use of cardioplegic cardiac arrest. This technique requires more time to perform and is more technically complex, but can significantly reduce myocardial ischemic time, which, in turn, significantly reduces the incidence of heart failure and postoperative complications.

Стилі APA, Harvard, Vancouver, ISO та ін.

20

Barbarovich, A. S., and D. P. Salivonchik. "CARDIOVASCULAR PATHOLOGY IN WOMEN: RISKS AND CHANCES (literature review)." Health and Ecology Issues, no. 4 (December 28, 2013): 53–58. http://dx.doi.org/10.51523/2708-6011.2013-10-4-9.

Повний текст джерела

Анотація:

The traditional view on cardiovascular pathology being the prerogative of the male population of the planet has not justified itself. Cardiovascular diseases also are the main cause of death in the female population, but the risk factors for cardiovascular pathology in men and women essentially differ. The review covers the basic pathogenetic mechanisms of development of cardiovascular pathology, basically, ischemic disease of heart in women.

Стилі APA, Harvard, Vancouver, ISO та ін.

21

Yeremina, O. V., M. M. Petrova, S. V. Prokopenko, N. V. Isaeva, and D. S. Kaskaeva. "COGNITIVE DYSFUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE." Bulletin of Siberian Medicine 13, no. 6 (December 28, 2014): 48–56. http://dx.doi.org/10.20538/1682-0363-2014-6-48-56.

Повний текст джерела

Анотація:

Coronary artery bypass graft surgery (CABG) is one of the most effective methods of surgical treatment of ischemic heart disease (IHD). However, even improvement of life quality is evident in patients underwent CABG, some neuropsychological, cognitive alterations may appear. Therefore, the problem of neurological complications in cardiac surgery is still of current interest. Prevalence of cognitive dysfunction after CABG varies from 12 to 79%. One third of the patients have alterations of cognitive functions for 1 year and more after the operation. In this review, we will discuss the current understandings on etiology, pathogenesis and prevalence of cognitive dysfunction in patients with IHD after CABG. The following factors determine development of long-lasting cognitive deficiency: lower educational level, advanced age, significant alterations of cognitive functions in preoperative period. At present, age, comorbid pathology (arterial hypertension, diabetes mellitus, vascular diseases, lung diseases), heart failure, alcohol and drug abuse, preoperative cognitive dysfunction are considered as major risk factors for CABG-induced neurological complications. Importance of timely diagnostics and early beginning of treatment of cognitive dysfunction will be discussed.

Стилі APA, Harvard, Vancouver, ISO та ін.

22

Zabusov, Yu G., M. V. Davydov, and A. Yu Zabusov. "Peculiarities of pathology and causes of death in homeless." Kazan medical journal 79, no. 3 (May 15, 1998): 185–88. http://dx.doi.org/10.17816/kazmj63991.

Повний текст джерела

Анотація:

The analysis of causes of death among definite contingent named tramps is carried out for the first time in home literature. It is shown that among forced causes of death supercooling prevails, and among somatic diseases ischemic heart disease and tuberculosis prevail. The difficulties in medicolegal diagnosis are noted in connection with polypathology observed in persons of no fixed address.

Стилі APA, Harvard, Vancouver, ISO та ін.

23

Chepelev, S. N., F. I. Vismont, and S. V. Goubkin. "On the significance of hyperlactatemia in the implementation of the infarct-limiting effect of remote ischemic postconditioning in myocardial ischemia-reperfusion in the experiment." Doklady of the National Academy of Sciences of Belarus 64, no. 3 (July 9, 2020): 332–40. http://dx.doi.org/10.29235/1561-8323-2020-64-3-332-340.

Повний текст джерела

Анотація:

Modern medicine faces the problem of the growth of cardiovascular pathology. Given the high medical and social significance of the problem of treating patients with coronary heart disease and acute myocardial infarction, the search for new effective methods to prevent or weaken ischemic myocardial damage and mechanisms for their implementation is an urgent task of modern experimental and clinical medicine. The aim of the study was to determine the significance of hyperlactatemia in the realization of the infarct-limiting effect of remote ischemic postconditioning (RIPostC) in rat myocardial ischemia-reperfusion in the experiment. The study revealed that after 15-minute RIPostC, which was performed 10 minutes after 30-minute acute myocardial ischemia followed by 120-minute reperfusion, the plasma lactate level in rats increased 1.87 times (87.7 %, p < 0.05) compared with intact animals. It was established that the introduction of L-lactate into the left common jugular vein at a dose of 10 μg/kg, which was carried out 25 minutes after the onset of reperfusion under the conditions of myocardial ischemia (30 minutes) and next reperfusion (120 minutes) and RIPostC (10 minutes after the onset of reperfusion), which was reproduced by ischemia of these limbs, have a heart attack-limiting effect. The increase of the level of blood lactate (hyperlactatemia) after RIPostC in myocardial ischemia-reperfusion is of significance in the implementation of its infarct-limiting effect.

Стилі APA, Harvard, Vancouver, ISO та ін.

24

Jargin, Sergei V. "Shock wave therapy of ischemic heart disease in the light of general pathology." International Journal of Cardiology 144, no. 1 (September 2010): 116–17. http://dx.doi.org/10.1016/j.ijcard.2008.12.198.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

25

Akramova, E. G. "The features of time characteristics of heart rate variability in chronic obstructive pulmonary disease." Kazan medical journal 93, no. 2 (April 15, 2012): 172–77. http://dx.doi.org/10.17816/kmj2281.

Повний текст джерела

Анотація:

Aim. To study the features of time characteristics of heart rate variability during isolated chronic obstructive pulmonary disease, as well as in association with arterial hypertension and ischemic heart disease. Methods. The characteristics of heart rate variability using Holter electrocardiography monitoring, echocardiography and duplex scanning of carotid arteries were studied. The results of investigations of 298 individuals of both sexes aged 37-78 years were included into the analysis, including 79 patients with chronic obstructive pulmonary disease who were divided into three groups. The first group included 19 patients with isolated chronic obstructive pulmonary disease, the second group consisted of 25 patients with chronic obstructive pulmonary disease and arterial hypertension, the third group included 35 patients with chronic obstructive pulmonary disease and ischemic heart disease, who were divided into two subgroups: patients with (n=9) and without (n=26) a prior history of myocardial infarction. For comparison, examined were 48 patients with isolated hypertension, 132 patients with ischemic heart disease and 39 practically healthy individuals. Results. In patients with isolated chronic obstructive pulmonary disease an autonomic imbalance occurs in the form of a uniform decrease in the activity of the parasympathetic nervous system during the day and an increase of the night time heart rate, identifiable are the signs of subclinical cardiac pathology in the form of thickening of the «intima-media» complex and the formation of atherosclerotic plaques in the carotid arteries, hypertrophy of the myocardium and left ventricular diastolic dysfunction, reduced systolic velocity of the mitral valve fibrous annulus. If chronic obstructive pulmonary disease is combined with aerterial hypertension and ischemic heart disease, as opposed to isolated cardiac pathology, a monotonic tachycardia develops during the day. In cases of concomitant chronic obstructive pulmonary disease and arterial hypertension during a simultaneous decrease in all time characteristics of heart rate variability, in most patients hypertrophy of both ventricles can be visualized. Conclusion. In patients with chronic obstructive pulmonary disease the time characteristics of heart rate variability depend on the presence or absence of concomitant diseases of the cardiovascular system.

Стилі APA, Harvard, Vancouver, ISO та ін.

26

Shloydo, Evgeny Antonovich, Igor Alexandrovich Pyaterichenko, Victoria Valentinovna Zvereva, Yuriy Romanovich Kovalev, and Alexey Viktorovich Sizov. "Endovascular treatment in patients with combined pathology." Pediatrician (St. Petersburg) 6, no. 3 (September 15, 2015): 123–28. http://dx.doi.org/10.17816/ped63123-128.

Повний текст джерела

Анотація:

Aortic valve stenosis is one of the most common diseases from the group of acquired heart disease, especially in elderly patients. Aortic valve replacement has become the “gold standard” and gives excellent results in all age groups of patients. For aortic valve replacement is sent to only one third of patients due to high risk due to age, severity of the defect, reduced contractility of the left ventricle, pulmonary hypertension and other comorbidities. One of the attempts to reduce the frequency of complications and mortality in this group of patients, and subsequently to make it possible to perform other surgical interventions, including aortic valve replacement, which is considered inoperable patients is holding a less traumatic surgery - aortic balloon catheter valvuloplasty. In the clinical observation deals with the case of heart disease - critical aortic stenosis, ischemic heart disease complicated by pulmonary hypertension and severe heart failure, in combination with gynecological diseases (uterine fibroids, endometrial hyperplasia in postmenopausal women), complicated by uterine bleeding and hemorrhagic anemia. Consider the risks of different surgical interventions. The possibility of modern endovascular care of patients in this situation simultaneously perform operations on uterine artery embolization, coronary angioplasty with stenting and aortic catheter balloon valvuloplasty. Also shown is the nearest and remote results of operative intervention.

Стилі APA, Harvard, Vancouver, ISO та ін.

27

Maksimova, Olga V., and Viktoriia G. Chobitko. "Myxedema coma. Case report." Terapevticheskii arkhiv 93, no. 10 (October 15, 2021): 1217–20. http://dx.doi.org/10.26442/00403660.2021.10.201080.

Повний текст джерела

Анотація:

A rare case of hypothyroid coma developed in a patient with diagnosed primary hypothyroidism, complicated by the development of rhabdomyolysis and prolonged oppression of the respiratory center is presented. The predominance of previous cardiovascular pathology, marked oedema syndrome, and hypercholesterolemia in the clinical picture of the disease initially directed the diagnostics of cardiac pathology, which delayed the diagnosis of hypothyroidism. This publication aims to draw clinicians' attention to hypothyroid coma as a rare complication of hypothyroidism, which in this case was disguised as ischemic heart disease with the development of chronic heart failure.

Стилі APA, Harvard, Vancouver, ISO та ін.

28

Nosov, A. E., A. S. Baydina, and O. Yu Ustinova. "Aerogenic pollutants as risk factors causing development of cardio-metabolic pathology (Review)." Health Risk Analysis, no. 4 (December 2021): 181–94. http://dx.doi.org/10.21668/health.risk/2021.4.20.

Повний текст джерела

Анотація:

Ambient air pollution causes approximately 3.3 million untimely deaths annually (2.1 deaths due to ischemic heart disease and 1.1 million deaths due to stroke). Mortality caused by ambient air pollution is higher than mortality due to such traditional risk factors as smoking, obesity, and elevated dextrose contents in blood. Relative risk of mortality amounts to 1.26 (95 % CI 1.08–1.47) in cities with the highest air pollution against those where air pollution is the lowest. Occupational exposure to various chemical air pollutants can cause more than 1 million untimely deaths all over the world but its contribution to prevalence of cardiovascular diseases has not been determined sufficiently. Aerogenic pollutants are quite variable in their chemical structure and include both particulate matter (PM for short) and gaseous matter. The American Heart Association and the European Society of Cardiology consider PM2.5 to be a risk factor causing cardiovascular diseases. This analytical review presents data on effects produced by aerogenic pollutants on development of cardio-metabolic pathology and population mortality due to vascular and metabolic diseases (arterial hypertension, atherosclerosis and ischemic heart disease, heart rhythm disturbances, and type 2 diabetes mellitus). There are also data on mechanisms of pathogenetic influence exerted by aerogenic pollutants on development of such diseases including generation of anti-inflammatory and oxidative mediators and their release into blood flow; developing imbalance in the autonomic nervous system with prevailing activity of the sympathetic nervous system and disrupted heart rate variability; direct introduction of aerogenic pollutants from the lungs into blood flow with developing direct toxic effects. We have also analyzed literature data on protective effects produced by reduction in ambient air pollution on prevalence of cardiovascular pathology.

Стилі APA, Harvard, Vancouver, ISO та ін.

29

Nosov, A. E., A. S. Baydina, and O. Yu Ustinova. "Aerogenic pollutants as risk factors causing development of cardio-metabolic pathology (Review)." Health Risk Analysis, no. 4 (December 2021): 178–90. http://dx.doi.org/10.21668/health.risk/2021.4.20.eng.

Повний текст джерела

Анотація:

Ambient air pollution causes approximately 3.3 million untimely deaths annually (2.1 deaths due to ischemic heart disease and 1.1 million deaths due to stroke). Mortality caused by ambient air pollution is higher than mortality due to such traditional risk factors as smoking, obesity, and elevated dextrose contents in blood. Relative risk of mortality amounts to 1.26 (95 % CI 1.08–1.47) in cities with the highest air pollution against those where air pollution is the lowest. Occupational exposure to various chemical air pollutants can cause more than 1 million untimely deaths all over the world but its contribution to prevalence of cardiovascular diseases has not been determined sufficiently. Aerogenic pollutants are quite variable in their chemical structure and include both particulate matter (PM for short) and gaseous matter. The American Heart Association and the European Society of Cardiology consider PM2.5 to be a risk factor causing cardiovascular diseases. This analytical review presents data on effects produced by aerogenic pollutants on development of cardio-metabolic pathology and population mortality due to vascular and metabolic diseases (arterial hypertension, atherosclerosis and ischemic heart disease, heart rhythm disturbances, and type 2 diabetes mellitus). There are also data on mechanisms of pathogenetic influence exerted by aerogenic pollutants on development of such diseases including generation of anti-inflammatory and oxidative mediators and their release into blood flow; developing imbalance in the autonomic nervous system with prevailing activity of the sympathetic nervous system and disrupted heart rate variability; direct introduction of aerogenic pollutants from the lungs into blood flow with developing direct toxic effects. We have also analyzed literature data on protective effects produced by reduction in ambient air pollution on prevalence of cardiovascular pathology.

Стилі APA, Harvard, Vancouver, ISO та ін.

30

Kuryachenko, Yu T., and N. V. Oleksyuk. "Clinical peculiarities in the course of cardioembolic stroke in patients with cardiac pathology." Bulletin of Siberian Medicine 7, no. 5-1 (December 30, 2008): 220–23. http://dx.doi.org/10.20538/1682-0363-2008-5-1-220-223.

Повний текст джерела

Анотація:

Revealing the particularities of the ischemic stroke course in patients with different types of cardiac pathology, with disturbances of the rhythm first of all, can play the certain role in forecast and tactic of the treatment of this disease. Analysis of the clinical particularities of the cardioembolic stroke course, depending on infarction localizations and type accompanying heart pathology was made. Examination of 61 patients, with determination degree of stroke gravity using American Scale (NIH-NINDS) on 1-st, 3-d and 10-th day of the disease was performed. The positive correlation was revealed between patients age and cardioembolic stroke frequency, cardiac rhythm disturbances and primary localization of the ischemia in pool of the left middle cerebral artery. The permanent form of the precordial twinkling is the most disadvantage prognosis factor and associated with forming the more severe neurological deficit.

Стилі APA, Harvard, Vancouver, ISO та ін.

31

Chepelev, S. N., and F. I. Vismont. "Significance of nitrogen monoxide in the implementation of the infarctlimiting effect of remote ischemic postconditioning in myocardial ischemia-reperfusion in young and old rats." Proceedings of the National Academy of Sciences of Belarus, Medical series 17, no. 3 (August 29, 2020): 353–63. http://dx.doi.org/10.29235/1814-6023-2020-17-3-353-363.

Повний текст джерела

Анотація:

Modern medicine faces the problem of a steady growth of cardiovascular pathology. Given the high medical and social significance of the problem of treating patients with coronary heart disease and acute myocardial infarction, the search for new effective methods to prevent or mitigate ischemic myocardial damage and mechanisms for their implementation is an urgent task of modern experimental and clinical medicine. The aim of the study was to determine the significance of nitric monoxide in realizing the infarction-limiting effect of remote ischemic postconditioning (RIPostC) in myocardial ischemia-reperfusion in young and old rats. The study revealed that RIPostC has a heart attack-limiting effect in myocardial ischemia-reperfusion in both young and old rats; however, under the conditions of the systemic action of the NG-nitro-L-arginine methyl ester inhibitor at a dose of 25 mg/kg (intravenous administration 5 min before the start of reperfusion and 15 min before RIPostC), the effect remains, although not completely, in old rats but not in young rats. Apparently, the NO synthase activity and the blood level of nitric monoxide play a more significant role in the mechanisms of the cardioprotective effects of RIPostC in young rats than in old rats.

Стилі APA, Harvard, Vancouver, ISO та ін.

32

Gandhi, Priyanka S., and Bhavna N. Gamit. "The role of platelet indices in ischemic heart disease: a hospital based case control type of study." International Journal of Research in Medical Sciences 7, no. 9 (August 27, 2019): 3426. http://dx.doi.org/10.18203/2320-6012.ijrms20193924.

Повний текст джерела

Анотація:

Background: In developing countries, Ischemic heart diseases (IHD) is one of the leading causes of morbidity and mortality. The underlying pathology of CAD is atherosclerosis. When this atherosclerotic plaque ruptures, platelets play a crucial role in the prothrombotic events and forms a thrombus on this plaque and as a result coronary artery gets occluded causing ischemia and infarction. Platelet contains many chemokines, cytokines and growth factors. Release of these factors along with interaction with endothelial cells and leukocytes promotes inflammation and progression of atherosclerosis. We aimed to investigate the association between platelet volume indices in patients with diagnosis of Ischemic heart disease in comparison with control group.Methods: By using automated cell counter platelet count and platelet volume indices - were compared with Normal healthy or non-cardiac chest pain patients with the use of unpaired t test.Results: In the present study, we demonstrated that platelet count is significantly low and MPV and PDW are significantly high in Ischemic heart disease as compared to patients with noncardiac chest pain or healthy subjects. The correlation of MPV with PC revealed an inverse correlation between the patients of IHD and healthy or non-cardiac chest pain patients which is statistically significant.Conclusions: The platelet volume indices are an important, simple, effortless and a cost-effective tool useful in predicting the development of an acute coronary event sometimes in the near future and therapeutic modification for improved patient’s cardiovascular care.

Стилі APA, Harvard, Vancouver, ISO та ін.

33

Komamura, Kazuo, Masufumi Kitakaze, Koichi Node, Tetsuo Minamino, Toshinao Kurihara, Kanji Funaya, Hiroaki Kosaka, Masatsugu Hori, Michitoshi Inoue, and Takenobu Kamada. "Endogenous nitric oxide inhibits microthromboembolism in the ischemic heart." Pathophysiology 1 (November 1994): 154. http://dx.doi.org/10.1016/0928-4680(94)90326-3.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

34

Svyrydova, N., N. Ingula, І. Bieliakova, N. Ruda, K. Pidgirna, and A. Shcherbaty. "The condition of the ischemic stroke: clinical cause." East European Journal of Neurology, no. 3(9) (September 20, 2016): 40–46. http://dx.doi.org/10.33444/2411-5797.2016.3(9).40-46.

Повний текст джерела

Анотація:

Cardiovascular diseases (CVD) – represent between 30 percent to 50 percent of all cardiovascular system’s diseases, and account 110 thousands of new stroke cases every year in Ukraine, death rate during first 30 days is 30-40 % and 50 % during 1st year. Primary stroke morbidity is higher in 1.5-2 times than world’s average. The most significant risk factors of stroke are hypertension, heart diseases (coronary artery disease, heart rhythm disorders), transient ischemic attack in anamnesis, diabetes, atherosclerosis (dyslipidemia). According conducted researches it is proven, that level of systolic blood pressure correlates with decreased risk of stroke in patients with hypertension. This article describes a case from clinical practice – management of patient with acute ischemic stroke. The attention is focused on the methods of examination, basic treatment strategy and rehabilitation of patient with this pathology.

Стилі APA, Harvard, Vancouver, ISO та ін.

35

Kadykova, O. I. "GENETIC ASPECTS OF DEVELOPMENT AND PROGRESSION OF CONGESTIVE HEART FAILURE IN PATIENTS WITH ISCHEMIC HEART DISEASE AND OBESITY∗." Problems of Endocrine Pathology 57, no. 3 (August 23, 2016): 17–21. http://dx.doi.org/10.21856/j-pep.2016.3.02.

Повний текст джерела

Анотація:

In this article elucidated the influence of allelic polymorphism of Gln27Glu of β2-adrenoceptors gene on patients that have coronary heart disease and obesity on the expansion and progression of congestive heart failure and left ventricular systolic dysfunction by surveying 222 patients. Presence of C allel of polymorphous locus Gln27Glu of β2-adrenoreceptors gene in patients with ischemic heart disease and concomitant obesity was associated with decreased risk of development of congestive heart failure (p < 0.05). The obtained data shown the absence of influence of polymorphous variants of β2-adrenoreceptors gene on progression of congestive heart failure in patients with ischemic heart disease and obesity (p > 0.05).

Стилі APA, Harvard, Vancouver, ISO та ін.

36

Kiziukevich, O., S. Spiridonov, A. Zhyhalkovich, and D. Isachkin. "SURGICAL TREATMENT OF PSEUDOANEURYSM OF THE FREE LEFT VENTRICLE WALL: A CLINICAL CASE." Emergency Cardiology and Cardiovascular Risks 5, no. 1 (2021): 1195–201. http://dx.doi.org/10.51922/2616-633x.2021.5.2.1195.

Повний текст джерела

Анотація:

Today diseases of the cardiovascular system are the leading cause of death in many countries. The key role in this pathology is played by ischemic heart disease. An extreme manifestation of ischemic heart disease - myocardial infarction is one of the main causes of complications and mortality in patients with ischemic heart disease. One of the most formidable complications of acute myocardial infarction is heart rupture, which most often leads to death, more than 60% of cases occurring in the prehospital stage. Many studies of similar groups of patients show a wide spread in assessing the incidence and mortality of this pathology. The development of myocardial ruptures has two frequency peaks: the first day and 5-7 days from the onset of AMI. The most common case is acute rupture of the free wall of the left ventricle with extensive hemorrhage in the pericardium leading to a fulminant death. The development of a pseudoaneurysm of the left ventricle is a very rare outcome of the myocardial rupture. There are no convincing data on the incidence of pseudoaneurysms as a result of myocardial infarction (according to many authors, it is less than 0.5% of all cases of myocardial infarction). This type of rupture is most favorable in terms of the possibility of providing assistance. The complexity of providing care to patients with pseudoaneurysms of the left ventricle lies in their low frequency of occurrence and often asymptomatic nature of the course, which complicates the diagnosis of this pathology. Timely diagnosis plays a key role in avoiding a fatal outcome, since the vast majority of pseudoaneurysms are extremely unstable and, except occasional cases, require urgent surgical intervention. This article describes a clinical case of a patient who underwent surgical treatment for pseudoaneurysm of the free wall of the left ventricle as a result of myocardial infarction. The article also presents a brief literature review of the available isolated data on risk factors for myocardial rupture, methods of diagnosis and treatment of this pathology.

Стилі APA, Harvard, Vancouver, ISO та ін.

37

Schlecht, Anja, Mario Vallon, Nicole Wagner, Süleyman Ergün та Barbara M. Braunger. "TGFβ-Neurotrophin Interactions in Heart, Retina, and Brain". Biomolecules 11, № 9 (14 вересня 2021): 1360. http://dx.doi.org/10.3390/biom11091360.

Повний текст джерела

Анотація:

Ischemic insults to the heart and brain, i.e., myocardial and cerebral infarction, respectively, are amongst the leading causes of death worldwide. While there are therapeutic options to allow reperfusion of ischemic myocardial and brain tissue by reopening obstructed vessels, mitigating primary tissue damage, post-infarction inflammation and tissue remodeling can lead to secondary tissue damage. Similarly, ischemia in retinal tissue is the driving force in the progression of neovascular eye diseases such as diabetic retinopathy (DR) and age-related macular degeneration (AMD), which eventually lead to functional blindness, if left untreated. Intriguingly, the easily observable retinal blood vessels can be used as a window to the heart and brain to allow judgement of microvascular damages in diseases such as diabetes or hypertension. The complex neuronal and endocrine interactions between heart, retina and brain have also been appreciated in myocardial infarction, ischemic stroke, and retinal diseases. To describe the intimate relationship between the individual tissues, we use the terms heart-brain and brain-retina axis in this review and focus on the role of transforming growth factor β (TGFβ) and neurotrophins in regulation of these axes under physiologic and pathologic conditions. Moreover, we particularly discuss their roles in inflammation and repair following ischemic/neovascular insults. As there is evidence that TGFβ signaling has the potential to regulate expression of neurotrophins, it is tempting to speculate, and is discussed here, that cross-talk between TGFβ and neurotrophin signaling protects cells from harmful and/or damaging events in the heart, retina, and brain.

Стилі APA, Harvard, Vancouver, ISO та ін.

38

Wallen, W. Jack, Michael P. Belanger, and Carin Wittnich. "Preischemic administration of ribose to delay the onset of irreversible ischemic injury and improve function: studies in normal and hypertrophied hearts." Canadian Journal of Physiology and Pharmacology 81, no. 1 (January 1, 2003): 40–47. http://dx.doi.org/10.1139/y03-018.

Повний текст джерела

Анотація:

Compared with normal hearts, those with pathology (hypertrophy) are less tolerant of metabolic stresses such as ischemia. Pharmacologic intervention administered prior to such stress could provide significant protection. This study determined, firstly, whether the pentose sugar ribose, previously shown to improve postischemic recovery of energy stores and function, protects against ischemia when administered as a pretreatment. Secondly, the efficacy of this same pretreatment protocol was determined in hearts with pathology (hypertrophy). For study 1, SpragueDawley rats received equal volumes of either vehicle (bolus i.v. saline) or ribose (100 mg/kg) before global myocardial ischemia. In study 2, spontaneously hypertensive rats (SHR; blood pressure [Formula: see text] 200/130) with myocardial hypertrophy underwent the same treatment protocol and assessments. In vivo left ventricular function was measured and myocardial metabolites and tolerance to ischemia were assessed. In normal hearts, ribose pretreatment significantly elevated the heart's energy stores (glycogen), and delayed the onset of irreversible ischemic injury by 25%. However, in vivo ventricular relaxation was reduced by 41% in the ribose group. In SHR, ribose pretreatment did not produce significant elevations in the heart's energy or improvements in tolerance to global ischemia, but significantly improved ventricular function (maximal rate of pressure rise (+dP/dtmax), 25%; normalized contractility ((+dP/dt)/P), 13%) despite no change in hemody na mics. Thus, administration of ribose in advance of global myocardial ischemia does provide metabolic benefit in normal hearts. However, in hypertrophied hearts, ribose did not affect ischemic tolerance but improved ventricular function.Key words: ribose, SHR, ischemia, ventricular function, metabolism.

Стилі APA, Harvard, Vancouver, ISO та ін.

39

Babaev, A. M., and Dzh B. Zul’fugarova. "Features of coronary artery disease in patients with different genotypes of PAI-1 gene." Kazan medical journal 98, no. 2 (April 15, 2017): 199–203. http://dx.doi.org/10.17750/kmj2017-199.

Повний текст джерела

Анотація:

Aim. To investigate the relation of different genotypes and alleles of PAI-1 gene with the course of coronary artery disease. Methods. We observed 80 patients with coronary artery disease (51 males and 29 females) aged 39 to 65 years living in the city of Baku. Genotyping of a polymorphic marker 4G(-675)5G was performed by means of polymerase chain reaction followed by restriction fragment length analysis. Genomic deoxyribonucleic acid (DNA) was extracted from venous blood leukocytes. To determine the frequency distribution of genotypes and alleles of PAI-1 in ischemic heart disease all patients were divided into 6 groups depending on the course of the disease and its outcomes. Results. In the population of Baku genotype 44 of PAI-1 gene is significantly more common in people with coronary artery disease compared to individuals without coronary artery disease and is a risk factor for this disease. Genotype 55 of PAI-1 gene is more common in people without coronary artery disease and thus is a protective genotype against this disease. Allele 4 of PAI-1 was statistically more frequently recorded in patients with ischemic heart disease, and allele 5 was significantly more frequently observed in patients without this pathology. Therefore, allele 4 is a risk factor for the occurrence of coronary heart disease and allele 5 is protective against this disease. Alleles 5 and 4 are not associated with the course and outcomes of ischemic heart disease. Conclusion. According to the results of the study on the population of Baku, genotype 44 of PAI-1 gene is a risk factor of ischemic heart disease, genotype 55 of PAI-1 gene is protective against this pathology, allele 4 is characteristic for people with coronary artery disease (a risk factor), allele 5 is characteristic for people without it (protective role) whereas the named genotypes of PAI-1 are not connected to the course and outcomes of this disease.

Стилі APA, Harvard, Vancouver, ISO та ін.

40

Laschi, Renzo, Edmondo Govoni, Giovanna Cenacchi, Bruno Magnani, Giorgio Binetti, and Flavio Tartagni. "Case 1: Primary Metabolic Cardiomyopathy Mimicking an Ischemic Heart Disease." Ultrastructural Pathology 10, no. 5 (January 1986): 387–94. http://dx.doi.org/10.3109/01913128609007191.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

41

Hopkins, David A., Sara E. Macdonald, David A. Murphy, and J. Andrew Armour. "Pathology of intrinsic cardiac neurons from ischemic human hearts." Anatomical Record 259, no. 4 (2000): 424–36. http://dx.doi.org/10.1002/1097-0185(20000801)259:4<424::aid-ar60>3.0.co;2-j.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

42

Balestrini, Christopher S., Baraa K. Al-Khazraji, Neville Suskin, and J. Kevin Shoemaker. "Does vascular stiffness predict white matter hyperintensity burden in ischemic heart disease with preserved ejection fraction?" American Journal of Physiology-Heart and Circulatory Physiology 318, no. 6 (June 1, 2020): H1401—H1409. http://dx.doi.org/10.1152/ajpheart.00057.2020.

Повний текст джерела

Анотація:

This study found that patients with ischemic heart disease (IHD) with preserved ejection fraction and normal blood pressures exhibit greater carotid β-stiffness, as well as middle cerebral artery pulsatility and resistive indexes, than controls. White matter lesion volume (WMLv) was not different between vascular pathology groups. Cerebrovascular pulse wave transit time (ccPWTT) and carotid β-stiffness independently associate with WMLv in pooled participant data, suggesting that regardless of heart disease history, ccPWTT and β-stiffness are associated with structural white matter damage.

Стилі APA, Harvard, Vancouver, ISO та ін.

43

Bezrukov, Vladislav, Liana Kuprush, Nina Sykalo, Tetyana Panteleymonova, Ludmila Sharabura, and Vitaliy Olar. "Effect of ATP and molsidomine combination on contractile function of isolated adult and old rat hearts during adequate coronary perfusion, at ischemia and reperfusion." Ageing & Longevity, no. 2 (July 7, 2021): 8–17. http://dx.doi.org/10.47855/jal9020-2021-2-2.

Повний текст джерела

Анотація:

Abstract. Pathology of the cardiovascular system occupies a major place in the structure of diseases of the elderly and old patients. Metabolic disturbances are very important in ischemic damages of myocardium in the elderly and old people. So, drugі with metabolic mechanism of action is very ppromising in the treatment of elderly patients with cardiovascular diseases. The relevance of this study is determined by the feasibility of using drugs of metabolic action, which have a beneficial effect on the metabolism of cardiomyocytes, improve blood supply to the myocardium, increase its contractile function. The effect of ATP-molsidomine combination on myocardial contractility in different age animals was stuiesy in vitro experiments. The experiments on the isolated hearts from adult and old rats have shown that combined use of ATP and molsidomine did not significantly affect the contractility of the isolated hearts of adult rats under different perfusion regimes. In old rats, the use of ATP-molsidomine combination had a positive effect on the contractile function of the myocardium under the influence of damaging factors (ischemia, reperfusion): prevented a decrease of left ventricular developing pressure and its first derivative (velocity of pressure rise and velocity of pressure decline) and accelerated its growth during reperfusion. Co-administration of ATP and molsidomine during ischemia had a positive effect on the heart rhythm and restored heart rate at the reperfusion period in adult and old rats. The results of the study indicate a positive effect of the ATP-molsidomine combination on the myocardial contractility in old rats. Combined use of ATP and molsidomine exerted a favourable influence on the heart rhythm under damaging factors both in the adult and old animals. Key words: ATP; molsidomine; isolated rat heart; myocardial contractility; ageing

Стилі APA, Harvard, Vancouver, ISO та ін.

44

Buja, L. Maximilian, and Richard S. Vander Heide. "Pathobiology of Ischemic Heart Disease: Past, Present and Future." Cardiovascular Pathology 25, no. 3 (May 2016): 214–20. http://dx.doi.org/10.1016/j.carpath.2016.01.007.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

45

Svyrydova, N. K., Y. V. Ponomarenko, N. І. Ingula, І. М. Bieliakova, and N. R. Ruda. "The condition of the acute cerebral circulation for the ischemic type: clinical cause." East European Journal of Neurology, no. 1(7) (March 20, 2016): 6–11. http://dx.doi.org/10.33444/2411-5797.2016.1(7).6-11.

Повний текст джерела

Анотація:

Cardiovascular diseases (CVD) – represent between 30 percent to 50 percent of all cardiovascular system’s diseases, and account 110 thousands of new stroke cases every year in Ukraine, death rate during first 30 days is 30-40 % and 50 % during 1st year. Primary stroke morbidity is higher in 1.5-2 times than world’s average. The most significant risk factors of stroke are hypertension, heart diseases (coronary artery disease, heart rhythm disorders), transient ischemic attack in anamnesis, diabetes, atherosclerosis (dyslipidemia). According conducted researches it is proven, that level of systolic blood pressure correlates with decreased risk of stroke in patients with hypertension. This article describes a case from clinical practice – management of patient with acute ischemic stroke. The attention is focused on the methods of examination, basic treatment strategy and rehabilitation of patient with this pathology.

Стилі APA, Harvard, Vancouver, ISO та ін.

46

Svyrydova, N., N. Ingula, І. Bieliakova, N. Ruda, K. Pidgirna, and A. Shcherbaty. "Clinical Case: Condition of the patient after repeated acute cerebrovascular disruption by ischemic type in the basin of the right middle cerebral artery with left-sided hemiparesis." East European Journal of Neurology, no. 4(22) (December 20, 2018): 32–37. http://dx.doi.org/10.33444/2411-5797.2018.4(22).32-37.

Повний текст джерела

Анотація:

Cardiovascular diseases (CVD) – represent between 30 percent to 50 percent of all cardiovascular system’s diseases, and account 110 thousands of new stroke cases every year in Ukraine, death rate during first 30 days is 30-40 % and 50 % during 1st year. Primary stroke morbidity is higher in 1.5-2 times than world’s average. The most significant risk factors of stroke are hypertension, heart diseases (coronary artery disease, heart rhythm disorders), transient ischemic attack in anamnesis, diabetes, atherosclerosis (dyslipidemia). According conducted researches it is proven, that level of systolic blood pressure correlates with decreased risk of stroke in patients with hypertension. This article describes a case from clinical practice – management of patient with acute ischemic stroke. The attention is focused on the methods of examination, basic treatment strategy and rehabilitation of patient with this pathology.

Стилі APA, Harvard, Vancouver, ISO та ін.

47

Zabbarova, A. T., E. I. Bogdanov, and M. M. Ibatullin. "Clinical and MRI peculiarities of chronical forms of cerebral circulation disorders in men and women with arterial hypertension." Neurology Bulletin XXXIV, no. 1-2 (April 15, 2002): 16–21. http://dx.doi.org/10.17816/nb87506.

Повний текст джерела

Анотація:

It had been performed a correlation of clinical and MRI characteristics of hypertonic angioencellopathy of cronical forms in men and women. It was done for the purpose of investigating sexual factor significance in cerebrovascular pathology. 50 men and 35 women who had clinical manifestations of discirculatory encephalopathy have been examined. It was revealed that in men paresis development is manly determined by total volume of brain substance lesion and by presence of large cortical-subcortical infactions, striocapsular infarctions and edge-zone infarctions; in women cognitive disorders are determined by total volume of brain substance. Diffuse forms are spread in men with accompanying ischemic heart disease, in women with prolonged arterial hypertension and with high level of arterial pressure. Ischemic heart disease in women is a result of the disease focal form.

Стилі APA, Harvard, Vancouver, ISO та ін.

48

Manusha, Yu I., Yu M. Kazakov, T. A. Trybrat, N. I. Chekalina, and K. Ye Vakulenko. "CLINICAL COURSE OF ISCHEMIC HEART DISEASE UNDER CONDITIONS OF COMORBIDITY WITH NON-ALCOHOLIC FATTY LIVER DISEASE." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 19, no. 3 (November 8, 2019): 52–56. http://dx.doi.org/10.31718/2077-1096.19.3.52.

Повний текст джерела

Анотація:

The actual problem of modern medicine is the identification of common pathogenetic mechanisms of IHD and NAFLD in order to develop a complex, personalized approach in treatment and prevention of comorbid pathology. Aim of the study: to determine the clinical course peculiarities of ischemic heart disease under conditions of comorbidity with non-alcoholic fatty liver disease. The study involved 135 patients with ischemic heart disease: stable voltage angina, I-II FC, HF 0-1, combined with non-alcoholic fatty liver disease and 30 healthy individuals. At the first stage of the study an assessment of ischemic heart disease tendencies under circumstances of concomitant NAFLD was conducted taking into consideration the peculiarities of clinical symptoms, and in comparison groups there was no significant difference discovered eventually in cardiovascular systems complaints, which were caused by IHD development. In patients with IHD combined with NAFLD the incidence of myocardial bioelectric activity disorders and the frequency of rhythm disorders prevailed comparing to patients with IHD. A significant increase in total cholesterol and a blood atherogenic index was found in patients with IHD combined with NAFLD compared to the patients with IHD (p <0.05) in the analysis of lipidogram indices. No significant difference among other lipidogram indicators (LDL cholesterol, HDL cholesterol, TG) was observed (p> 0.05). Thus, the detected lipid metabolism disorders were noted in patients with IHD combined with NAFLD at statin therapy. Due to results of echocardiography a diastolic dysfunction and a moderate decrease of systolic function were found in both study groups comparing to the healthy group, regardless of the presence or absence of NAFLD. A higher incidence of LV hypertrophy was observed in patients with comorbid pathology.

Стилі APA, Harvard, Vancouver, ISO та ін.

49

Bagisheva, N. V., A. V. Mordyk, I. A. Viktorova, and D. I. Trukhan. "Cardiovascular pathology in patients with newly diagnosed tuberculosis and chronic obstructive pulmonary disease." Meditsinskiy sovet = Medical Council, no. 14 (October 18, 2021): 142–48. http://dx.doi.org/10.21518/2079-701x-2021-14-142-148.

Повний текст джерела

Анотація:

Introduction. Chronic obstructive pulmonary disease and cardiovascular diseases (arterial hypertension, ischemic heart disease, chronic heart failure) are among the comorbid conditions that mutually aggravate each other. The addition of tuberculosis in this category of patients requires additional efforts from the doctor to improve treatment outcomes.Purpose. Тo assess the prevalence of chronic obstructive pulmonary disease, arterial hypertension, coronary heart disease and chronic heart failure in patients with newly diagnosed tuberculosis hospitalized in an anti-tuberculosis hospital.Materials and methods. We examined 462 patients with newly diagnosed tuberculosis, hospitalized in a tuberculosis dispensary, aged 17 to 88 years, the median (Me (P25; 75) age was 43.68 (32.00; 54.00) years, including 266 men (57.6%) and 196 women (42.4%) All patients underwent clinical, laboratory, instrumental examination to establish or confirm the diagnosis.Results. The incidence of chronic obstructive pulmonary disease among patients with newly diagnosed tuberculosis was 31.4%, with arterial hypertension – 12.1%, coronary heart disease – 6.1%, chronic heart failure – 6.1%. The incidence of cardiovascular pathology in the group of tuberculosis + chronic obstructive pulmonary disease was 40%, in the group of tuberculosis without chronic obstructive pulmonary disease 6%.Conclusions. The prevalence of comorbid cardiovascular pathology in patients with tuberculosis + chronic obstructive pulmonary disease is significantly higher than among patients with only tuberculosis, which requires the involvement of doctors of various specialties to manage this category of patients to prevent adverse treatment outcomes, disability and mortality.

Стилі APA, Harvard, Vancouver, ISO та ін.

50

Mazurov, V. I., S. V. Stolov, I. B. Belyaeva, and E. A. Trofimov. "THE PARTICIPATION OF IMMUNE AND INFLAMMATORY MECHANISMSIN THE PATHOGENESIS OF CORONARY ATHEROSCLEROSIS." HERALD of North-Western State Medical University named after I.I. Mechnikov 7, no. 4 (December 15, 2015): 13–23. http://dx.doi.org/10.17816/mechnikov20157413-23.

Повний текст джерела

Анотація:

It was revealed that in development of a coronary atherosclerosis, participate the immune-mediated mechanisms. In blood of patients with coronary atherosclerosis the maintenance of the basic classes cytokines (IL-1 β, IL-2, IL-6, IL-8, TNF-a) were increased. Development of acute coronary insufficiency is accompanied by additional increase of levels of the data cytokines. The accessory of the cytokine activity to a coronary atherosclerosis was confirmed at studying the maintenance mRNA cytokines in a vascular wall. Thus in a zone atheromatous (aorta) it was synthesized mainly mRNA IL-2, while in a zone lipomatosis (a beam radial artery) it is formed nonspecific immune reaction with development of the mRNA IL-1 and IL-6. For patients with rheumatoid arthritis typically more active defeat of a coronary arteries, in comparison with healthy persons. Chronic immune-mediated process in frameworks of the autoimmune pathology can serve a trigger for accelerated development ischemic heart disease. The General immune-inflammatory mechanisms which participate in pathogenesis of the ischemic heart disease and rheumatoid arthritis, allow to spend the certain parallels between atherosclerotic process and autoimmune pathology.

Стилі APA, Harvard, Vancouver, ISO та ін.

Статті в журналах з теми "Ischemic pathology of heart"

Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями