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Добірка наукової літератури з теми "Intraductal Tubulopapillary Neoplasm"

Автор: Grafiati
Опубліковано: 10 грудня 2022
Оновлено: 29 січня 2023

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Статті в журналах з теми "Intraductal Tubulopapillary Neoplasm"

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Kim, Hyunsung, and Jae Y. Ro. "Intraductal Tubulopapillary Neoplasm of the Pancreas: An Overview." Archives of Pathology & Laboratory Medicine 142, no. 3 (March 1, 2018): 420–23. http://dx.doi.org/10.5858/arpa.2016-0405-rsr2.

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Анотація:
Intraductal tubulopapillary neoplasm is a rare tumor that the World Health Organization recognized in 2010 as a subtype of premalignant pancreatic neoplasms. It is important to distinguish it from other intraductal neoplasms, including intraductal papillary mucinous neoplasm, pancreatic ductal adenocarcinoma, and intraductal variant of acinar cell carcinoma, because intraductal tubulopapillary neoplasm has a favorable prognosis. Histopathologically, intraductal tubulopapillary neoplasms are characterized by tubulopapillary growth, uniform high-grade cytologic atypia, frequent necrotic foci, evident ductal differentiation, and absence of mucin. Intraductal tubulopapillary neoplasms show distinct immunohistochemical and molecular findings, with positive cytokeratin 7, cytokeratin 19, MUC1, and MUC6, and somatic PIK3CA mutations (2 of 11; 18%), and low rates of KRAS (2 of 20; 10%), TP53 (5 of 22; 23%), and BRAF (2 of 13; 15%) mutations. These differences also highlight the fact that intraductal tubulopapillary pancreatic neoplasm is distinct from other similar neoplasms.
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2

Yu, Catherine, Julie Lokan, Louise Jackett, Mehrdad Nikfarjam, and Christopher Mills. "Intraductal tubulopapillary neoplasm." BMJ Case Reports 15, no. 12 (December 2022): e246398. http://dx.doi.org/10.1136/bcr-2021-246398.

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Анотація:
A man aged above 70 years old with a medical history of ulcerative colitis presented with unintentional weight loss. A pancreatic mass associated with pancreatic duct dilatation was detected on imaging procedures. Initial investigations including fine needle aspiration and cytology examination were inconclusive. A diagnosis of intraductal tubulopapillary neoplasm (ITPN) was made with histopathology and immunohistochemistry examination on a surgically resected specimen. Two years after surgery, the patient remained well with no radiological evidence of recurrence.ITPN is a rare pancreatic duct tumour with limited case reports in medical literature. Risk factors are not well established. We report the first case of ITPN occurring in a patient with ulcerative colitis. A typical presentation of this rare tumour is reported to encourage clinicians to consider ITPN in the differential diagnoses of a pancreatic mass.
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YAMAGUCHI, Hiroshi. "Pancreatic intraductal neoplasms-intraductal papillary mucinous neoplasm and intraductal tubulopapillary neoplasm." Suizo 35, no. 4 (August 31, 2020): 250–57. http://dx.doi.org/10.2958/suizo.35.250.

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4

Ozcan, Kerem, and David S. Klimstra. "A Review of Mucinous Cystic and Intraductal Neoplasms of the Pancreatobiliary Tract." Archives of Pathology & Laboratory Medicine 146, no. 3 (February 22, 2022): 298–311. http://dx.doi.org/10.5858/arpa.2021-0399-ra.

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Анотація:
Context.— Although most pancreatic and bile duct neoplasms are solid, mucinous cystic neoplasms and intraductal neoplasms have been increasingly recognized even when clinically silent, thanks to the increased use of sensitive imaging techniques. Cystic and intraductal neoplasms of the pancreas are often resectable and curable and constitute about 5% of all pancreatic neoplasms. Owing to their preinvasive nature and different biology, recognition of these entities remains a major priority. Mucinous cystic neoplasms are histologically and clinically distinct from other cystic pancreatic neoplasms. Pancreatic intraductal neoplasms encompass 3 major entities: intraductal papillary mucinous neoplasm, intraductal oncocytic papillary neoplasm, and intraductal tubulopapillary neoplasm. Intraductal papillary neoplasms of bile ducts are also preinvasive mass-forming neoplasms with both similarities and differences with their pancreatic counterparts. All of these pancreatobiliary neoplasms have diverse and distinctive clinicopathologic, genetic, and prognostic variations. Objective.— To review the clinical, pathologic, and molecular features of mucinous cystic and intraductal neoplasms of the pancreatobiliary tract. Data Sources.— Literature review, diagnostic manuals, and guidelines. Conclusions.— This review will briefly describe well-known clinical and pathologic features and will focus on selected recently described aspects of morphology, grading, classification, and genomic alterations of cystic and intraductal neoplasms of the pancreatobiliary tract.
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Basturk, Olca, Volkan Adsay, Gokce Askan, Deepti Dhall, Giuseppe Zamboni, Michio Shimizu, Karina Cymes, et al. "Intraductal Tubulopapillary Neoplasm of the Pancreas." American Journal of Surgical Pathology 41, no. 3 (March 2017): 313–25. http://dx.doi.org/10.1097/pas.0000000000000782.

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Rooney, Sarah L., and Jiaqi Shi. "Intraductal Tubulopapillary Neoplasm of the Pancreas: An Update From a Pathologist's Perspective." Archives of Pathology & Laboratory Medicine 140, no. 10 (October 1, 2016): 1068–73. http://dx.doi.org/10.5858/arpa.2016-0207-ra.

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Анотація:
Context.—Intraductal tubulopapillary neoplasm (ITPN) is a rare intraductal epithelial neoplasm of the pancreas recently recognized as a distinct entity by the World Health Organization classification in 2010. It is defined as an intraductal, grossly visible, tubule-forming epithelial neoplasm with high-grade dysplasia and ductal differentiation without overt production of mucin. The diagnosis can be challenging owing to morphologic overlap with other intraductal lesions and its rarity. While recent advances in molecular genetic studies of ITPN have provided new tools to facilitate clinical diagnosis, the limited number of cases has yielded limited follow-up data to guide management. Objective.—To provide a clinical, pathologic, and molecular update on ITPN with respect to clinical presentation, imaging findings, histopathologic features, differential diagnosis, biological behavior, molecular characteristics, and treatment options. Data Sources.—Analysis of the pertinent literature (PubMed) and authors' research and clinical practice experience based on institutional and consultation materials. Conclusions.—Clinical presentation, imaging findings, histopathology, immunohistochemistry studies, molecular characteristics, prognosis, and treatment options of ITPN are reviewed. Important differential diagnoses with other intraductal neoplasms of the pancreas—especially intraductal papillary mucinous neoplasm—using histopathologic, molecular, and immunohistochemical studies, are discussed. Despite the recent progress, more studies are necessary to assess the biology and genetics of ITPN for a better understanding of the prognostic factors and treatment options.
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7

Kitaguchi, Kazuhiko, Yuichiro Kato, Motohiro Kojima, Satoshi Okubo, Daigoro Takahashi, Rei Okada, Yusuke Nakayama, et al. "A Resected Case of Intraductal Tubulopapillary Neoplasm of the Pancreas: Report of a Case." International Surgery 100, no. 2 (February 1, 2015): 281–86. http://dx.doi.org/10.9738/intsurg-d-14-00172.1.

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Анотація:
The patient was a 61-year-old male who was referred to our hospital after dilatation of the main pancreatic duct was detected by screening ultrasonography. Computed tomography revealed a protruding lesion measuring 15 mm in diameter within the main pancreatic duct in the head of the pancreas, and magnetic resonance cholangiopancreatography revealed interruption of the duct at the tumor site. We performed pancreaticoduodenectomy under a suspected diagnosis of invasive ductal carcinoma. Gross examination of the resected specimen showed that the tumor invaginated into the main pancreatic duct, and no mucin was found. Histological examination revealed proliferation of high-grade dysplastic cells in a tubulopapillary growth pattern. Immunohistochemically, cytokeratin 7 expression was detected, but not trypsin expression. Based on these morphological features, we diagnosed the tumor as intraductal tubulopapillary neoplasm (ITPN). We report the case with bibliographic consideration, together with a review of intraductal neoplasms of the pancreas encountered at our institution.
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8

Bledsoe, Jacob R., Shweta A. Shinagare, and Vikram Deshpande. "Difficult Diagnostic Problems in Pancreatobiliary Neoplasia." Archives of Pathology & Laboratory Medicine 139, no. 7 (July 1, 2015): 848–57. http://dx.doi.org/10.5858/arpa.2014-0205-ra.

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Анотація:
Context Many common diagnostic dilemmas are encountered in pancreatobiliary pathology, frequently resulting in uncertainty on behalf of the pathologist and referral for a second opinion. Objectives To review 4 common diagnostic dilemmas encountered in the practice of pancreatobiliary pathology: (1) pancreatic ductal adenocarcinoma versus chronic pancreatitis; (2) pancreatic ductal carcinoma versus adenocarcinomas arising in the ampulla and intrapancreatic common bile duct; (3) the distinction of uncommon intraductal neoplasms—intraductal oncocytic papillary neoplasm, intraductal tubulopapillary neoplasm, and intraductal acinar cell carcinoma; and (4) intrahepatic cholangiocarcinoma versus metastatic carcinoma. Data Sources A review of pertinent literature, along with the authors' personal experience, based on institutional and consultation materials. Conclusions Important diagnostic features for a few challenging problems in pancreatobiliary pathology are reviewed. Careful study of the microscopic features along with awareness of differential diagnoses and diagnostic pitfalls generally allows distinction of these entities. We also highlight established and novel ancillary studies that help to arrive at an accurate diagnosis.
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Wu, Chia-Hung, Yi-Chen Yeh, Yu-Chuan Tsuei, Li-Kuo Huang, Chia-I. Lin, Chien-An Liu, Hsiou-Shan Tseng, Yi-You Chiou, and Nai-Chi Chiu. "Comparative radiological pathological study of biliary intraductal tubulopapillary neoplasm and biliary intraductal papillary mucinous neoplasm." Abdominal Radiology 42, no. 10 (May 3, 2017): 2460–69. http://dx.doi.org/10.1007/s00261-017-1167-7.

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Basturk, Olca, Michael F. Berger, Hiroshi Yamaguchi, Volkan Adsay, Gokce Askan, Umesh K. Bhanot, Ahmet Zehir, et al. "Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma." Modern Pathology 30, no. 12 (August 4, 2017): 1760–72. http://dx.doi.org/10.1038/modpathol.2017.60.

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Більше джерел

Дисертації з теми "Intraductal Tubulopapillary Neoplasm"

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Kuan, Li Lian. "Studies on benign hepatic and pancreatic pathology." Thesis, 2021. https://hdl.handle.net/2440/136623.

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Анотація:
Background Malignant pathologies of hepatic and pancreatic lesions have been widely reported. However, benign pancreatic and hepatic pathologies are infrequently focused on owing to their innocuous nature. The significance of indeterminate liver lesions (ILL) and a novel pancreatic entity - intraductal tubulopapillary neoplasm (ITPN) are explored. With the escalating incidence of obesity, a better understanding of fat distribution, metabolism, and its clinical implications are critical to managing pancreatitis. Visceral adipose tissue (VAT) and sarcopenia are valued as contributors to prognosis and outcomes in these patients. Objective The pathologies of ILL and ITPN pose a diagnostic conundrum and have created a management dilemma for clinicians. This thesis examines the characteristics and natural history of these pathologies, and attempt to provide current strategies to aid diagnosis and management. This thesis also focuses on the impact of VAT and sarcopenia in pancreatitis. The main purpose is to highlight the current data available and identify gaps in knowledge surrounding these pathologies. Design The four papers contributing to this thesis include a retrospective cohort study, a review and two systematic reviews. The retrospective cohort study consisted of a retrospective analysis of prospectively collected data from a single institution for eight years. The systematic reviews utilised NCBI PubMed, EMBASE as data sources and selected all studies published since 2000. Results The results cover an overview of clinical, radiological, histopathological, and molecular features, as well as the prognosis and up to date management of ILL and ITPN. The cohort study concluded that small (<15 mm) hepatic lesions discovered incidentally in patients with no known primary malignancy and risk factors are virtually always benign, with a 1% risk of malignancy. The review on ITPN discovered that the diagnosis of ITPN is invariably made post-operatively and is considered to be a precursor lesion to carcinomas but has a favourable prognosis. The systematic review on VAT identified 11 studies. Nine studies showed a statistically significant association between VAT and the severity of AP. Four studies found VAT to be a risk factor for acute pancreatitis. Two studies showed VAT is associated with an increased risk of local complications and two other studies showed a correlation between VAT and mortality. The systematic review on sarcopenia in chronic pancreatitis (CP) analysed six studies. The prevalence of sarcopenia in CP from all studies ranged from 17-62%. Sarcopenia was associated with a reduced quality of life, increased hospitalisation, and reduced survival. Conclusion This thesis provides the foundation for further work to be undertaken on these surgically challenging diseases. There is a need for a classification system, which stratifies ILLs by malignant potential based on a standardized and evidence-based approach. Further studies are essential to elucidate the natural history of ITPN to guide the best treatment strategy and determine survival. The systematic reviews established that VAT and sarcopenia have significant prognostic values and should be incorporated into prognostic scores of pancreatitis and future prospective analyses. A multidisciplinary approach in an experienced hepatobiliary and pancreatic centre is recommended for the management of these challenging benign pathologies.
Thesis (MPhil) -- University of Adelaide, Adelaide Medical School, 2022
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Частини книг з теми "Intraductal Tubulopapillary Neoplasm"

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Kawamoto, Satomi. "Case 89: Intraductal Tubulopapillary Neoplasm." In Pancreatic Imaging, 385–89. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-52680-5_89.

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Karamitopoulou-Diamantis, Eva. "Intraductal Tubulopapillary Neoplasm (ITPN) and ITPN with Associated Invasive Component." In Encyclopedia of Pathology, 1–6. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-28845-1_5540-1.

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Karamitopoulou-Diamantis, Eva. "Intraductal Tubulopapillary Neoplasm (ITPN) and ITPN with Associated Invasive Component." In Pathology of the Pancreas, 105–10. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-62416-3_5540.

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"Intraductal Tubulopapillary Neoplasm." In Diagnostic Pathology: Hepatobiliary and Pancreas, 398–99. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-323-44307-4.50136-6.

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Тези доповідей конференцій з теми "Intraductal Tubulopapillary Neoplasm"

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Gonzalez Haba, M., B. Agudo Castillo, F. Pons Renedo, C. Gonzalez Lois, JPO Rojas, P. Ibarrola Arevalo, and JLC Panero. "INTRADUCTAL TUBULOPAPILLARY NEOPLASM (ITPN) AN UNUSUAL PANCREATIC LESION - A CASE REPORT." In ESGE Days. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1704106.

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