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Статті в журналах з теми "Interns (Medicine) Victoria"

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Автор: Grafiati

Опубліковано: 10 грудня 2022

Оновлено: 29 січня 2023

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1

Piterman, Leon, and Chris Silagy. "Hospital interns' and residents' perceptions of rural training and practice in Victoria." Medical Journal of Australia 155, no. 9 (November 1991): 630–33. http://dx.doi.org/10.5694/j.1326-5377.1991.tb93934.x.

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2

Azer, Sarah, Munad Khan, Nathan Hoag, Riteesh Bookun, Nathan Lawrentschuk, Richard Grills, and Damien Bolton. "Interns’ perceptions of exposure to urology during medical school education in Victoria, Australia." ANZ Journal of Surgery 87, no. 1-2 (January 2017): 10–11. http://dx.doi.org/10.1111/ans.13769.

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3

Brick, Aarón. "Guadalupe Victoria tenía abuelo gachupín." Relaciones Estudios de Historia y Sociedad 42, no. 165 (December 1, 2021): 179. http://dx.doi.org/10.24901/rehs.v42i165.759.

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El padre de Guadalupe Victoria nació en Salamanca, Michoacán (hoy Guanajuato) en 1750. Este artículo contiene los primeros datos publicados sobre sus orígenes, en la forma de tres partidas sacramentales. Lo suministrado nos ayuda para refinar el entendimiento del federalismo y republicanismo de su hijo, el eventual guerrilla y Presidente. De interés especial es el hecho que Guadalupe Victoria tenía un abuelo peninsular.

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4

CHENG, A. C., K. D. WINKEL, G. M. HAWDON, and M. McDONALD. "Irukandji-like syndrome in Victoria." Australian and New Zealand Journal of Medicine 29, no. 6 (December 1999): 835. http://dx.doi.org/10.1111/j.1445-5994.1999.tb00797.x.

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5

Špinar, Jindřich, Lenka Špinarová, and Jiří Vítovec. "Vericiguat in patients with heart failure and reduced ejection fraction." Vnitřní lékařství 67, no. 3 (May 26, 2021): 180–82. http://dx.doi.org/10.36290/vnl.2021.041.

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6

Shavarova, E., E. Kazahmedov, A. Orlov, and Zh Kobalava. "[PP.03.04] VICTORIA STUDY." Journal of Hypertension 35 (September 2017): e109. http://dx.doi.org/10.1097/01.hjh.0000523265.78065.22.

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7

Nagao, K. J., A. Koschel, H. M. Haines, L. E. Bolitho, and B. Yan. "Rural Victorian Telestroke project." Internal Medicine Journal 42, no. 10 (October 2012): 1088–95. http://dx.doi.org/10.1111/j.1445-5994.2011.02603.x.

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8

Shadur, B., J. MacLachlan, and B. Cowie. "Hepatitis D virus in Victoria 2000-2009." Internal Medicine Journal 43, no. 10 (October 2013): 1081–87. http://dx.doi.org/10.1111/imj.12247.

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9

McCOLL, G. J., A. G. FRAUMAN, J. P. DOWLING, and G. A. VARIGOS. "A report of Lyme disease in Victoria." Australian and New Zealand Journal of Medicine 24, no. 3 (June 1994): 324–25. http://dx.doi.org/10.1111/j.1445-5994.1994.tb02189.x.

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10

Hiscock, H., K. Ledgerwood, M. Danchin, E. Ekinci, E. Johnson, and A. Wilson. "Clinical research potential in Victorian hospitals: the Victorian clinician researcher needs analysis survey." Internal Medicine Journal 44, no. 5 (May 2014): 477–82. http://dx.doi.org/10.1111/imj.12396.

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11

Sinclair, M., S. Roberts, W. Kemp, V. Knight, A. Dev, P. Gow, H. Philpott, et al. "Epidemiology of hepatitis B-associated hepatocellular carcinoma in Victoria." Internal Medicine Journal 43, no. 5 (May 2013): 501–6. http://dx.doi.org/10.1111/imj.12068.

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12

Marshman, R. S. A. "Prevalence of Pulmonary Sarcoidosis in the State of Victoria, Australia." Acta Medica Scandinavica 176, S425 (April 24, 2009): 167–68. http://dx.doi.org/10.1111/j.0954-6820.1964.tb05742.x.

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13

Abramson, M., J. Kutin, and G. Bowes. "The prevalence of asthma in Victorian adults." Australian and New Zealand Journal of Medicine 22, no. 4 (August 1992): 358–63. http://dx.doi.org/10.1111/j.1445-5994.1992.tb02148.x.

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14

Simmons, David, Anne McKenzie, Simon Eaton, Jonathan Shaw, and Paul Zimmet. "Prevalence of diabetes in rural Victoria." Diabetes Research and Clinical Practice 70, no. 3 (December 2005): 287–90. http://dx.doi.org/10.1016/j.diabres.2005.04.004.

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15

KOO, W. W. K. "ACUTE EPIGLOTTITIS IN CHILDHOOD: REPORT OF AN INCREASED INCIDENCE IN VICTORIA." Australian and New Zealand Journal of Medicine 15, no. 1 (February 1985): 83. http://dx.doi.org/10.1111/j.1445-5994.1985.tb02749.x.

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16

Velusamy, Ragani, Brady Thomson, and Annabel Martin. "Regional Victoria physician subspecialty training and workforce: the current state of play." Internal Medicine Journal 52, no. 2 (February 2022): 310–14. http://dx.doi.org/10.1111/imj.15679.

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17

Brennan, Frank. "The Victorian Voluntary Assisted Dying Act comes into operation." Internal Medicine Journal 49, no. 6 (June 2019): 689–93. http://dx.doi.org/10.1111/imj.14314.

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18

Piedra Gonzalez, Aitor, Javier Peña López, Adri Sánchez Ballesta, and Toni Caparrós Pons. "Uso del índice de esfuerzo percibido en contextos competitivos de baloncesto femenino y masculino." Revista Andaluza de Medicina del Deporte 14, no. 4 (July 9, 2020): 204–9. http://dx.doi.org/10.33155/j.ramd.2020.07.003.

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Objetivo: valorar la aplicabilidad del índice de esfuerzo percibido como herramienta para el control de la carga interna en baloncesto femenino y masculino. Método: se llevó a cabo un estudio descriptivo, observacional y prospectivo durante una temporada completa. En cada sesión de entrenamiento se registraron tiempo de exposición, índice de esfuerzo percibido, carga de trabajo, lesionabilidad y el rendimiento durante la competición. Resultados: El equipo femenino mostró una media de esfuerzo percibido de 4.8 ± 1.52 y 9 lesiones “time-loss” y el masculino un esfuerzo percibido de 4.24 ± 2.23 y 7 lesiones “time-loss”. Las variables analizadas se comportaron de manera independiente entre los equipos (p<0.01). Se observaron correlaciones significativas en ambos equipos: grandes y moderadas para esfuerzo percibido y tiempo de exposición (p<0.01); bajas para esfuerzo percibido y valoración (p<0.01); moderadas y triviales para esfuerzo percibido y victoria (p<0.023) y bajas para carga de trabajo y valoración (p<0.01). Además, fueron triviales para esfuerzo percibido y lesión “physio attention” en el equipo femenino (p<0.01) y para esfuerzo percibido y lesiones “time-loss” en el masculino (p<0.002). Conclusiones: Los resultados sugieren que el índice de esfuerzo percibido es una herramienta útil para el control de carga interna en baloncesto, asociada al rendimiento y la lesionabilidad.

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19

Zubrinich, Celia, Jo Douglass, James Bartlett, Mittal Patel, and Mark Hew. "Anaphylaxis presentations to the emergency department: impending Victorian reporting legislation." Internal Medicine Journal 49, no. 1 (January 2019): 135–36. http://dx.doi.org/10.1111/imj.14181.

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20

Thurnheer, M. C., T. R. Schulz, T. Nguyen, J. MacLachlan, and J. Sasadeusz. "Regional challenges: evaluation of a hepatitis outreach programme using transient elastography (FibroScan) in Victoria." Internal Medicine Journal 46, no. 3 (March 2016): 273–81. http://dx.doi.org/10.1111/imj.12963.

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21

O'Hara, D., and I. McDonald. "Trends in in-hospital mortality following acute myocardial infarction (AMI) in Victoria, 1987-1994." Australian and New Zealand Journal of Medicine 27, no. 4 (August 1997): 431–36. http://dx.doi.org/10.1111/j.1445-5994.1997.tb02202.x.

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22

Duke, G., A. Barker, J. Santamaria, and M. Graco. "Recent trends in Victorian risk-adjusted in-hospital mortality: 1999-2009." Internal Medicine Journal 42, no. 11 (November 2012): 1218–23. http://dx.doi.org/10.1111/j.1445-5994.2012.02797.x.

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23

Bray, J. E., K. Coughlan, I. Mosley, B. Barger, and C. Bladin. "Are suspected stroke patients identified by paramedics transported to appropriate stroke centres in Victoria, Australia?" Internal Medicine Journal 44, no. 5 (May 2014): 515–18. http://dx.doi.org/10.1111/imj.12382.

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24

Volkers, Nancy. "Winning Health Victories with Community Commitment." Annals of Internal Medicine 127, no. 12 (December 15, 1997): 1148. http://dx.doi.org/10.7326/0003-4819-127-12-199712150-00051.

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25

Welz, M., W. Gee, B. Workman, and J. Morton. "Documentation and identification of substitute decision-makers/persons responsible in residential aged care facilities in Victoria." Internal Medicine Journal 46, no. 10 (October 2016): 1235–36. http://dx.doi.org/10.1111/imj.13208.

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26

STOREY, E., M. COOK, R. PEPPARD, H. NEWTON-JOHN, and E. BYRNE. "GUILLAIN-BARRÉ SYNDROME AND RELATED CONDITIONS IN VICTORIAN TEACHING HOSPITALS 1980-84." Australian and New Zealand Journal of Medicine 19, no. 6 (December 1989): 687–93. http://dx.doi.org/10.1111/j.1445-5994.1989.tb00335.x.

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27

Rao, Nisha, and Nigel D. Toussaint. "Hip fractures in patients with chronic kidney disease admitted to Victorian hospitals." Internal Medicine Journal 49, no. 5 (May 2019): 658–61. http://dx.doi.org/10.1111/imj.14280.

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28

Levinson, M., A. Mills, A. M. Hutchinson, G. Heriot, G. Stephenson, and A. Gellie. "Comparison of not for resuscitation (NFR) forms across five Victorian health services." Internal Medicine Journal 44, no. 7 (July 2014): 671–75. http://dx.doi.org/10.1111/imj.12458.

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29

Aldridge, Robyn, Wendy Cutchie, Fiona Townsing, Sarah Hay, Bernadette White, Peri Dyson, Theresa Bowditch, et al. "P127 3Centres Collaboration clinical practice guidelines – towards uniform clinical practice in Victoria." Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health 1 (October 2010): S76. http://dx.doi.org/10.1016/s2210-7789(10)60293-0.

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30

Jeffery, Paul, Caryl Nowson, Lynn Riddell, Mary-Anne Land, Jonathan Shaw, Jacqui Webster, John Chalmers, Wayne Smith, Victoria Flood, and Bruce Neal. "1118 QUANTIFYING SALT AND POTASSIUM INTAKE IN VICTORIAN ADULTS." Journal of Hypertension 30 (September 2012): e327. http://dx.doi.org/10.1097/01.hjh.0000420576.44472.df.

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31

Farquhar, J. W. "The Place of Hypertension Control in Total Cardiovascular Health: Perspectives Outlined by the Victoria Declaration." Clinical and Experimental Hypertension 17, no. 7 (January 1, 1995): 1107–11. http://dx.doi.org/10.3109/10641969509033655.

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32

Lingaratnam, S., A. Mellerick, L. J. Worth, M. Green, S. Guy, S. Kirsa, M. Slavin, W. Renwick, R. Filshie, and K. A. Thursky. "Feasibility of early discharge strategies for neutropenic fever: outcomes of a Victorian organisational readiness assessment and pilot." Internal Medicine Journal 43, no. 9 (September 2013): 979–86. http://dx.doi.org/10.1111/imj.12228.

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33

Bull, A. L., L. J. Worth, and M. J. Richards. "Implementation of standardised surveillance forClostridium difficileinfections in Australia: initial report from the Victorian Healthcare Associated Infection Surveillance System." Internal Medicine Journal 42, no. 6 (June 2012): 715–18. http://dx.doi.org/10.1111/j.1445-5994.2012.02804.x.

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34

Kis‐Rigo, Andrew, Anna Collins, Stacey Panozzo, and Jennifer Philip. "Negative media portrayal of palliative care: a content analysis of print media prior to the passage of Voluntary Assisted Dying legislation in Victoria." Internal Medicine Journal 51, no. 8 (August 2021): 1336–39. http://dx.doi.org/10.1111/imj.15458.

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35

Dunbar, James A., Abirami Jayawardena, Greg Johnson, Karen Roger, Amy Timoshanko, Vincent L. Versace, Jane Shill, et al. "Scaling Up Diabetes Prevention in Victoria, Australia: Policy Development, Implementation, and Evaluation." Diabetes Care 37, no. 4 (December 6, 2013): 934–42. http://dx.doi.org/10.2337/dc12-2647.

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36

Baguley, Brenton J., Michael Jefford, Ahmed Aly, Paul Cashin, and Victoria White. "Have centralised ethics and governance applications improved the time‐variable, and approval process to conduct research in Victorian hospitals?" Internal Medicine Journal 49, no. 6 (June 2019): 807–8. http://dx.doi.org/10.1111/imj.14276.

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37

Bohensky, M., A. Barker, R. Morello, R. N. De Steiger, A. Gorelik, and C. Brand. "Geographical variation in incidence of knee arthroscopy for patients with osteoarthritis: a population-based analysis of Victorian hospital separations data." Internal Medicine Journal 44, no. 6 (June 2014): 537–45. http://dx.doi.org/10.1111/imj.12438.

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38

Wong Silva, Benji. "TIC y la corrupción en las MYPES en el emporio de Gamarra, Municipio La Victoria, Lima 2019." Revista Relayn - Micro y Pequeñas empresas en Latinoamérica 1, no. 1 (February 21, 2020): 90–101. http://dx.doi.org/10.46990/relayn.2019.1.1.266.

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La corrupción ha sido severamente criticado; desde la propia conceptualización de qué es y los impactos que puede tener, el término “corrupción” puede relacionarse con un estado de la sociedad, en su conjunto, o con actos individuales. La corrupción describe a una sociedad o un estado que se ha alejado de un estándar de bondad (Johnston, 1996), y sus acciones corruptas violan las reglas de los cargos públicos y están motivadas por la ganancia privada (Nye, 1967);define una transacción ilegal en la que funcionarios públicos y actores privados intercambian bienes para su propio enriquecimiento a expensas de la sociedad en general (Lebedun & Weinberg, 1975) Constantemente los empresarios,, recurren a actos de corrupción derivados de dos motivos: a) para compensar el fracaso del sistema legal en la obtención de permisos y/o eludir procesos y trámites, mediante el pago de sobornos (Aidis & Adachi, 2007), o b) para obtener alguna ventaja , frente a la competencia. la corrupción también toca al lenguaje, la desconfianza se expresa en éste, lo que conduce a que la esfera pública se vacíe de sentido y se convierte en una máscara ritual, La corrupción en las MYPES ha recibido una mayor atención recientemente, debido al uso de información de portales públicos, esto viene tomando otras vertientes en la corrupción , también a serie de estudios limitados se han centrado en determinar si la corrupción las afecta de forma negativa o positiva, para los que la aplican será de manera positiva y los afectados negativamente (Mendoza, Lim & Lopez, 2015) y encontrando resultados , como el acceso a recursos financieros (Aterido, Hallward-Driemeier & Pagés, 2011); a mercados de libre competencia – ruptura de monopolios− ; Una competencia desigual produce desequilibrios y costos asimétricos que profundizan la desigualdad entre los grupos, crean formas de influencias ocultas. Existe interés de mejorar el ámbito tecnológico en este caminar se van descubriendo más cosas en el mundo cibernético y cada día es una innovación a nivel global que muchos países tratan de alcanzar en las diferentes perspectivas, pero cada día se da más usos indebidos en estos avances tecnológicos como lo es la corrupción La corrupción es objeto de investigación, análisis y discusión desde distintas perspectivas. Se conoce que económicamente y socialmente la corrupción afecta dañinamente a las empresas (MYPES), que tratan de estar al día con las innovaciones tecnológicas, pero les toca enfrentar el problema de corrupción Abstract Corruption has been severely criticized; from the very conceptualization of what it is and the impacts it can have, the term "corruption" can relate to a state of society, as a whole, or to individual acts. Corruption describes a society or state that has moved away from a standard of goodness (Johnston, 1996), and its corrupt actions violate the rules of public office and are motivated by private gain (Nye, 1967); it defines an illegal transaction in which public officials and private actors exchange goods for their own enrichment at the expense of society at large (Lebedun & Weinberg, 1975). Businessmen constantly resort to acts of corruption derived from two motives: a) to compensate for the failure of the legal system in obtaining permits and/or to avoid processes and procedures by paying bribes (Aidis & Adachi, 2007), or b) to obtain some advantage over the competition. Corruption also touches language, distrust is expressed in it, which leads to the public sphere being emptied of meaning and becomes a ritual mask, Corruption in MSEs has received greater attention recently, due to the use of information from public portals, this is taking other aspects of corruption, also to series of limited studies have focused on determining whether corruption affects them negatively or positively, for those who apply it will be positively and those affected negatively (Mendoza, Lim & Lopez, 2015) and finding results , such as access to financial resources (Aterido, Hallward-Driemeier & Pagés, 2011); to free competition markets - monopoly breaking- ; Unequal competition produces imbalances and asymmetric costs that deepen inequality between groups, create forms of hidden influences. There is interest in improving the technological field in this walk are discovering more things in the cyber world and every day is an innovation globally that many countries try to achieve in different perspectives, but every day there are more misuses in these technological advances such as corruption Corruption is the subject of research, analysis and discussion from different perspectives. It is known that economically and socially corruption affects companies (MYPES), which try to keep up with technological innovations, but they have to face the problem of corruption.

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39

Viray, Paul, Zi Low, Rabindra Sinnappu, Penelope A. Harvey, and Sandra Brown. "Residential aged care facility COVID ‐19 outbreaks and magnitude of spread among residents: observations from a Victorian residential in‐reach service." Internal Medicine Journal 51, no. 1 (January 2021): 99–101. http://dx.doi.org/10.1111/imj.15143.

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40

Gifford, S., and P. Zimmet. "A community approach to diabetes education in Australia — The Region 8 (Victoria) Diabetes Education and Control Program." Diabetes Research and Clinical Practice 2, no. 2 (January 1986): 105–12. http://dx.doi.org/10.1016/s0168-8227(86)80067-5.

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41

Simmons, David. "Characteristics and blood pressure management in patients with and without diabetes in primary care in rural Victoria." Diabetes Research and Clinical Practice 81, no. 1 (July 2008): 19–24. http://dx.doi.org/10.1016/j.diabres.2008.03.007.

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42

Underhill, Craig, Phillip Parente, Grant McArthur, Andrew Haydon, Sue‐Anne McLachlan, Zee Wan Wong, and Eva Segelov. "Towards new models of cancer care in Australia: lessons from Victoria's response to the COVID ‐19 pandemic." Internal Medicine Journal 50, no. 10 (September 20, 2020): 1282–85. http://dx.doi.org/10.1111/imj.15012.

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43

Silva Narvaste, Bertha, Jean Pierre Wong Silva, Adolfo Silva Narvaste, and Abel Hipolito Gallo Coca. "Incidencia de los Recursos humanos a través de las TIC en la competitividad las mypes textiles del emporio de Gamarra, del distrito de La Victoria, Lima." Revista Relayn - Micro y Pequeñas empresas en Latinoamérica 4, no. 1 (April 1, 2020): 97–107. http://dx.doi.org/10.46990/relayn.2020.4.1.104.

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El objetivo de este estudio fue analizar la incidencia de los recursos humanos a través de las TIC en la competitividad de la MYPES textiles del emporio de Gamarra, del distrito de La Victoria, se aplicó un cuestionario a una muestra de 393 empresas, se empleó una metodología cuantitativa, de alcance descriptivo, Los 393 empresarios, en cuanto a la escolaridad se encontró que el 3.7% no tenía la primaria terminada, el 5.3% estudió completa la primaria, el 35.1% estudió la secundaria, el 45.1% tienen grado de bachiller, 10.3% terminó la licenciatura y sólo el 0.5% restante tiene estudios de posgrado. Tiempo de los empresarios que dedican a la empresa, el promedio es de 62.7 horas a la semana. El 42,1 % de los directores de empresas usan programa especializado para gestionar y el 29,3 % algún programa para la producción, quienes usa algún programa especializado para administrar o para producir asciende a 45.5%. La herramienta tecnológica más usada para asuntos laborales es el Whatsapp con el 64.5%. Resalta que el 14.8% de la gente no utiliza redes sociales ni de manera personal ni para asuntos laborales, pudiendo ser un área de oportunidad para el municipio abordado. Se buscó estructurar una ruta que sirva de guía para potenciar a los recursos humanos con el uso de las TIC para enfrentar la competitividad. Frente a las exigencias de los consumidores, las empresas deben adquirir recursos, realizar operaciones internas y de comercialización empleando TIC, indispensables debido a la separación física y al tiempo del punto de fabricación o comercialización con respecto al punto destino de consumo. Por lo que, las TIC, se han convertido en un medio de desarrollo empresarial y fuente de ventaja competitiva en las Mypes Abstract The objective of this study was to analyze the impact of human resources through ICT on the competitiveness of the textile MYPES of the Gamarra emporium, in the district of La Victoria, a questionnaire was applied to a sample of 393 companies, a methodology was used uantitativa, of descriptive scope, The 393 entrepreneurs, in terms of schooling, found that 3.7% did not have the finished primary, 5.3% studied the primary complete, 35.1% studied the secondary school, 45.1% have a bachelor's degree, 10.3% finished and only the remaining 0.5% have graduate studies. Business time, the average is 62.7 hours a week.42.1% of company managers use specialized program to manage and 29.3% some production program, who use some specialized program to manage or to produce amounts to 45.5%. The most used technological tool for labor matters is Whatsapp with 64.5%. It emphasizes that 14.8% of people do not use social networks either personally or for labor matters, and it can be an area of opportunity for the municipality addressed. It is concluded that the impact of human resources through ICTs on the competitiveness of textile micro and small businesses, is therefore important, therefore the degree of knowledge of the use of ICT tools, helps to improve competitiveness.

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Pedreira, C. C., R. Hameed, S. Kanumakala, and M. Zacharin. "Health-care problems of Turner syndrome in the adult woman: a cross sectional study of a Victorian cohort and a case for transition." Internal Medicine Journal 36, no. 1 (January 2006): 54–57. http://dx.doi.org/10.1111/j.1445-5994.2005.00990.x.

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Elson, Roslyn. "A role for dietitians. A report on the Dietitians' Study Day: Victoria and Albert Museum, London, 13 May 1993." Practical Diabetes International 10, no. 4 (July 1993): 157. http://dx.doi.org/10.1002/pdi.1960100414.

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Lingaratnam, S., K. A. Thursky, M. A. Slavin, S. W. Kirsa, C. A. Bennett, and L. J. Worth. "The disease and economic burden of neutropenic fever in adult patients in Australian cancer treatment centres 2008: analysis of the Victorian Admitted Episodes Dataset." Internal Medicine Journal 41, no. 1b (January 2011): 121–29. http://dx.doi.org/10.1111/j.1445-5994.2010.02343.x.

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Tam, Constantine S., Gareth P. Gregory, Matthew Ku, Shaun Fleming, Sasanka M. Handunnetti, Denise Lee, Patricia Walker, et al. "Recommendation for TP53 mutation testing in newly diagnosed mantle cell lymphoma: a statement from working groups sponsored by the Victorian Comprehensive Cancer Centre." Internal Medicine Journal 52, no. 7 (July 2022): 1286–87. http://dx.doi.org/10.1111/imj.15851.

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Bizino, Maurice B., Ingrid M. Jazet, Paul de Heer, Huub J. van Eyk, Ilona A. Dekkers, Patrick C. N. Rensen, Elisabeth H. M. Paiman, Hildebrandus J. Lamb, and Johannes W. Smit. "Placebo-controlled randomised trial with liraglutide on magnetic resonance endpoints in individuals with type 2 diabetes: a pre-specified secondary study on ectopic fat accumulation." Diabetologia 63, no. 1 (November 5, 2019): 65–74. http://dx.doi.org/10.1007/s00125-019-05021-6.

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Abstract Aims/hypothesis The aim of this work was to assess the effect of liraglutide on ectopic fat accumulation in individuals with type 2 diabetes mellitus. Methods This study is a pre-specified subanalysis of the MAGNetic resonance Assessment of VICTOza efficacy in the Regression of cardiovascular dysfunction In type 2 diAbetes mellitus (MAGNA VICTORIA) study, with primary endpoints being the effects of liraglutide on left ventricular diastolic and systolic function. The MAGNA VICTORIA study was a single-centre, parallel-group trial in 50 individuals with type 2 diabetes mellitus (BMI >25 kg/m2) who were randomly assigned (1:1, stratified for sex and insulin use) to receive liraglutide 1.8 mg once daily or placebo for 26 weeks, added to standard care. Participants, study personnel and outcome assessors were blinded to treatment allocation. The secondary endpoints of visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (SAT) and epicardial fat were measured with MRI. Hepatic triacylglycerol content (HTGC) and myocardial triacylglycerol content (MTGC) were quantified with proton MR spectroscopy. Between-group differences (change from baseline) were tested for significance using ANCOVA. Mean differences with 95% CIs were reported. Results The trial was completed in 2016. Twenty-four participants were randomised to receive liraglutide and 26 to receive placebo. One patient in the liraglutide group withdrew consent before having received the study drug and was not included in the intention-to-treat analysis. Liraglutide (n = 23) vs placebo (n = 26) significantly reduced body weight (liraglutide 98.4 ± 13.8 kg to 94.3 ± 14.9 kg; placebo 94.5 ± 13.1 kg to 93.9 ± 13.2 kg; estimated treatment effect −4.5 [95% CI −6.4, −2.6] kg). HbA1c declined in both groups without a significant treatment effect of liraglutide vs placebo (liraglutide 66.7 ± 11.5 mmol/mol to 55.0 ± 13.2 mmol/mol [8.4 ± 1.1% to 7.3 ± 1.2%]; placebo 64.7 ± 10.2 mmol/mol to 56.9 ± 6.9 mmol/mol [8.2 ± 1.0% to 7.5 ± 0.7%]; estimated treatment effect −2.9 [95% CI −8.1, 2.3] mmol/mol or −0.3 [95% CI −0.8, 0.2]%). VAT did not change significantly between groups (liraglutide 207 ± 87 cm2 to 203 ± 88 cm2; placebo 204 ± 63 cm2 to 200 ± 55 cm2; estimated treatment effect −7 [95% CI −24, 10] cm2), while SAT was reduced by a significantly greater extent with liraglutide than with placebo (liraglutide 361 ± 142 cm2 to 339 ± 131 cm2; placebo 329 ± 107 cm2 to 333 ± 125 cm2; estimated treatment effect −29 [95% CI −51, −8] cm2). Epicardial fat did not change significantly between groups (liraglutide 8.9 ± 4.3 cm2 to 9.1 ± 4.7 cm2; placebo 9.6 ± 4.1 cm2 to 9.6 ± 4.6 cm2; estimated treatment effect 0.2 [95% CI −1.5, 1.8] cm2). Change in HTGC was not different between groups (liraglutide 18.1 ± 11.2% to 12.0 ± 7.7%; placebo 18.4 ± 9.4% to 14.7 ± 10.0%; estimated treatment effect −2.1 [95% CI −5.3, 1.0]%). MTGC was not different after treatment with liraglutide (1.5 ± 0.6% to 1.2 ± 0.6%) vs placebo (1.3 ± 0.5% to 1.2 ± 0.6%), with an estimated treatment effect of −0.1 (95% CI −0.4, 0.2)%. There were no adjudicated serious adverse events. Conclusions/interpretation Compared with placebo, liraglutide-treated participants lost significantly more body weight. Liraglutide primarily reduced subcutaneous fat but not visceral, hepatic, myocardial or epicardial fat. Future larger studies are needed to confirm the results of this secondary endpoint study. Trial registration ClinicalTrials.gov NCT01761318. Funding This study was funded by Novo Nordisk A/S (Bagsvaerd, Denmark).

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Chong, Jia W., Maria E. Craig, Fergus J. Cameron, Caroline F. Clarke, Christine P. Rodda, Susan M. Donath, and George A. Werther. "Marked increase in type 1 diabetes mellitus incidence in children aged 0?14 yr in Victoria, Australia, from 1999 to 2002." Pediatric Diabetes 8, no. 2 (April 2007): 67–73. http://dx.doi.org/10.1111/j.1399-5448.2007.00229.x.

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Dale, Katie, Maria Globan, Kristy Horan, Norelle Sherry, Susan Ballard, Ee Laine Tay, Simone Bittmann, et al. "Whole genome sequencing for tuberculosis in Victoria, Australia: A genomic implementation study from 2017 to 2020." Lancet Regional Health - Western Pacific 28 (November 2022): 100556. http://dx.doi.org/10.1016/j.lanwpc.2022.100556.

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