Добірка наукової літератури з теми "Interneurone cortical"

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Статті в журналах з теми "Interneurone cortical"

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Somogyi, Peter, and Thomas Klausberger. "Defined types of cortical interneurone structure space and spike timing in the hippocampus." Journal of Physiology 562, no. 1 (2004): 9–26. http://dx.doi.org/10.1113/jphysiol.2004.078915.

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Yang, Panzao, Joanne O. Davidson, Tania M. Fowke, et al. "Connexin Hemichannel Mimetic Peptide Attenuates Cortical Interneuron Loss and Perineuronal Net Disruption Following Cerebral Ischemia in Near-Term Fetal Sheep." International Journal of Molecular Sciences 21, no. 18 (2020): 6475. http://dx.doi.org/10.3390/ijms21186475.

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Perinatal hypoxia-ischemia is associated with disruption of cortical gamma-aminobutyric acid (GABA)ergic interneurons and their surrounding perineuronal nets, which may contribute to persisting neurological deficits. Blockade of connexin43 hemichannels using a mimetic peptide can alleviate seizures and injury after hypoxia-ischemia. In this study, we tested the hypothesis that connexin43 hemichannel blockade improves the integrity of cortical interneurons and perineuronal nets. Term-equivalent fetal sheep received 30 min of bilateral carotid artery occlusion, recovery for 90 min, followed by a
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Qiu, Fang, Xingfeng Mao, Penglai Liu, et al. "microRNA Deficiency in VIP+ Interneurons Leads to Cortical Circuit Dysfunction." Cerebral Cortex 30, no. 4 (2019): 2229–49. http://dx.doi.org/10.1093/cercor/bhz236.

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Abstract Genetically distinct GABAergic interneuron subtypes play diverse roles in cortical circuits. Previous studies revealed that microRNAs (miRNAs) are differentially expressed in cortical interneuron subtypes, and are essential for the normal migration, maturation, and survival of medial ganglionic eminence-derived interneuron subtypes. How miRNAs function in vasoactive intestinal peptide expressing (VIP+) interneurons derived from the caudal ganglionic eminence remains elusive. Here, we conditionally removed Dicer in postmitotic VIP+ interneurons to block miRNA biogenesis. We found that
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Fishell, Gord, and Adam Kepecs. "Interneuron Types as Attractors and Controllers." Annual Review of Neuroscience 43, no. 1 (2020): 1–30. http://dx.doi.org/10.1146/annurev-neuro-070918-050421.

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Cortical interneurons display striking differences in shape, physiology, and other attributes, challenging us to appropriately classify them. We previously suggested that interneuron types should be defined by their role in cortical processing. Here, we revisit the question of how to codify their diversity based upon their division of labor and function as controllers of cortical information flow. We suggest that developmental trajectories provide a guide for appreciating interneuron diversity and argue that subtype identity is generated using a configurational (rather than combinatorial) code
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Lukomska, Agnieszka, Grzegorz Dobrzanski, Monika Liguz-Lecznar, and Malgorzata Kossut. "Somatostatin receptors (SSTR1-5) on inhibitory interneurons in the barrel cortex." Brain Structure and Function 225, no. 1 (2019): 387–401. http://dx.doi.org/10.1007/s00429-019-02011-7.

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AbstractInhibitory interneurons in the cerebral cortex contain specific proteins or peptides characteristic for a certain interneuron subtype. In mice, three biochemical markers constitute non-overlapping interneuron populations, which account for 80–90% of all inhibitory cells. These interneurons express parvalbumin (PV), somatostatin (SST), or vasoactive intestinal peptide (VIP). SST is not only a marker of a specific interneuron subtype, but also an important neuropeptide that participates in numerous biochemical and signalling pathways in the brain via somatostatin receptors (SSTR1-5). In
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Ying, Guoxin, Sen Wu, Ruiqing Hou, Wei Huang, Mario R. Capecchi, and Qiang Wu. "The Protocadherin Gene Celsr3 Is Required for Interneuron Migration in the Mouse Forebrain." Molecular and Cellular Biology 29, no. 11 (2009): 3045–61. http://dx.doi.org/10.1128/mcb.00011-09.

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ABSTRACT Interneurons are extremely diverse in the mammalian brain and provide an essential balance for functional neural circuitry. The vast majority of murine cortical interneurons are generated in the subpallium and migrate tangentially over a long distance to acquire their final positions. By using a mouse line with a deletion of the Celsr3 (Flamingo, or Fmi1) gene and a knock-in of the green fluorescent protein reporter, we find that Celsr3, a member of the nonclustered protocadherin (Pcdh) family, is predominantly expressed in the cortical interneurons in adults and in the interneuron ge
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Lamsa, Karri, and Tomi Taira. "Use-Dependent Shift From Inhibitory to Excitatory GABAA Receptor Action in SP-O Interneurons in the Rat Hippocampal CA3 Area." Journal of Neurophysiology 90, no. 3 (2003): 1983–95. http://dx.doi.org/10.1152/jn.00060.2003.

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Cortical inhibitory interneurons set the pace of synchronous neuronal oscillations implicated in synaptic plasticity and various cognitive functions. The hyperpolarizing nature of inhibitory postsynaptic potentials (IPSPs) in interneurons has been considered crucial for the generation of oscillations at β (15–30 Hz) and γ (30–100 Hz) frequency. Hippocampal basket cells and axo-axonic cells in stratum pyramidale-oriens (S-PO) play a central role in the synchronization of the local interneuronal network as well as in pacing of glutamatergic principal cell firing. A lack of conventional forms of
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Howard, MacKenzie A., and Scott C. Baraban. "Synaptic integration of transplanted interneuron progenitor cells into native cortical networks." Journal of Neurophysiology 116, no. 2 (2016): 472–78. http://dx.doi.org/10.1152/jn.00321.2016.

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Interneuron-based cell transplantation is a powerful method to modify network function in a variety of neurological disorders, including epilepsy. Whether new interneurons integrate into native neural networks in a subtype-specific manner is not well understood, and the therapeutic mechanisms underlying interneuron-based cell therapy, including the role of synaptic inhibition, are debated. In this study, we tested subtype-specific integration of transplanted interneurons using acute cortical brain slices and visualized patch-clamp recordings to measure excitatory synaptic inputs, intrinsic pro
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Cruz-Santos, Maria, Lucia Fernandez Cardo, and Meng Li. "A Novel LHX6 Reporter Cell Line for Tracking Human iPSC-Derived Cortical Interneurons." Cells 11, no. 5 (2022): 853. http://dx.doi.org/10.3390/cells11050853.

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GABAergic interneurons control the neural circuitry and network activity in the brain. The dysfunction of cortical interneurons, especially those derived from the medial ganglionic eminence, contributes to neurological disease states. Pluripotent stem cell-derived interneurons provide a powerful tool for understanding the etiology of neuropsychiatric disorders, as well as having the potential to be used as medicine in cell therapy for neurological conditions such as epilepsy. Although large numbers of interneuron progenitors can be readily induced in vitro, the generation of defined interneuro
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Nestor, Michael W., Samson Jacob, Bruce Sun, et al. "Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies." American Journal of Physiology-Cell Physiology 308, no. 3 (2015): C209—C219. http://dx.doi.org/10.1152/ajpcell.00263.2014.

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Production and isolation of forebrain interneuron progenitors are essential for understanding cortical development and developing cell-based therapies for developmental and neurodegenerative disorders. We demonstrate production of a population of putative calretinin-positive bipolar interneurons that express markers consistent with caudal ganglionic eminence identities. Using serum-free embryoid bodies (SFEBs) generated from human inducible pluripotent stem cells (iPSCs), we demonstrate that these interneuron progenitors exhibit morphological, immunocytochemical, and electrophysiological hallm
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Дисертації з теми "Interneurone cortical"

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Touzot, Audrey. "Migration et spécification des interneurones GABAergiques corticaux issus de la CGE au cours du développement chez la souris." Thesis, Nice, 2014. http://www.theses.fr/2014NICE4089/document.

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Chez les rongeurs, les interneurones (INs) corticaux sont issus de l’éminence ganglionnaire (EG) médiale (MGE) et caudale (CGE), expriment une combinaison de facteurs définis et migrent tangentiellement puis radialement pour atteindre leur position laminaire définitive. La diversité et la spécification des sous-types d’INs provenant de la MGE ont suscité de nombreuses études, en revanche les mécanismes moléculaires contrôlant la migration et la spécification des INs issus de la CGE demeurent toujours obscurs. Dans cette étude, les voies de migration de ces INs ont été examinées grâce à une lig
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Wilmet, Baptiste. "Analyses des dysfonctions neuronales d’un modèle murin de Paraplégie Spastique Héréditaire." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLEP045.

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Les Paraplégies Spastiques Héréditaires sont un groupe de maladies du motoneurone caractérisées par une dégénérescence de l’axe corticospinal menant à la spasticité et une paralysie progressive des membres parfois associés à des troubles cognitifs. Des mutations dans le gène SPG11 codant pour la Spatacsine sont la majeure cause de ces formes complexes de HSP. Pour mieux comprendre les mécanismes responsables de la pathologie liée à SPG11, notre équipe a généré un modèle de souris Knock-out pour ce gène, mimant les déficits cognitifs et moteurs observés chez les patients, corrélés à des altérat
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Fleitas, Pérez Catherine. "FLRT proteins act as guidance cues for migrating cortical interneurons." Doctoral thesis, Universitat de Lleida, 2015. http://hdl.handle.net/10803/378646.

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The establishment of functional neuronal connectivity starts during development and depends on neuronal migration and the correct positioning of newborn neurons which integrate into specific layers of the cortex. The fibronectin and leucine-rich family of transmembrane proteins (FLRT) have evolved as new regulators of several aspects during nervous system development, including neuronal migration. This work is focused on the study of in vivo FLRTs involvement in the tangential migration of interneurons. For this, we have analyzed nervous system specific knockout animals for FLRT2 and FLRT3, si
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Leclech, Claire. "Etude de l'influence de la topographie du microenvironnement sur la migration des interneurones corticaux par l'utilisation de substrats microstructurés." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS245/document.

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Dans le cerveau en développement, les interneurones corticaux effectuent une longue migration avant de se positionner dans le cortex et s’intégrer dans les réseaux corticaux dont ils régulent l’activité. Différents facteurs chimiques ont été impliqués dans le guidage de ces cellules, mais l’influence des propriétés physiques de l’environnement dans lequel ils naviguent reste peu connue. Il a été montré que les indices topographiques peuvent guider le mouvement de nombreux types cellulaires, un processus appelé guidage par contact. Mes travaux de thèse ont ainsi cherché à tester et comprendre l
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Skowronski-Lutz, Ethan M. (Ethan Mikael). "Interneuron networks and cortical dynamics : emulated whisking drives SOM interneurons in the ketamine anesthetized mouse SI neocortex." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/95858.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>In the core of this thesis I test and confirm the hypothesis that separate classes of interneurons respond differentially to sensory stimulation independent of volitional or other top-down control on the part of the animal. I also test and confirm the hypothesis that, based only on bottom-up sensory stimulation the activity of two major classes of interneurons (adapting Parvalbumin positive and facilitating
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Courtin, Julien. "Role of cortical parvalbumin interneurons in fear behaviour." Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22045/document.

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Les processus d'apprentissage et de mémoire sont contrôlés par des circuits et éléments neuronaux spécifiques. De nombreuses études ont récemment mis en évidence que les circuits corticaux jouent un rôle important dans la régulation des comportements de peur, cependant, leurs caractéristiques anatomiques et fonctionnelles restent encore largement inconnues. Au cours de ma thèse, en utilisant des enregistrements unitaires et des approches optogénétiques chez la souris libre de se comporter, nous avons pu montrer que les interneurones inhibiteurs du cortex auditif et du cortex préfrontal médian
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Chang, Melissa McKenzie. "Secreted factors FGF and WNT in cortical interneuron specification." Thesis, New York University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3665119.

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<p> Cortical Interneurons are an incredibly diverse population of locally connecting GABAergic inhibitory neurons. In rodents, cortical interneurons originate from the ventral telencephalon during embryogenesis, and migrate tangentially into the neocortex following their specification. Despite our understanding of the early patterning of the telencephalon, established through sonic hedgehog (SHH), fibroblast growth factor (FGF) signaling, and wingless-int (WNT) we still know very little about the downstream effectors responsible for establishing interneuron diversity. This work has aimed to el
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Dupper, Amy Contole. "Altered cortical calbindin-immunoreactive interneuron populations associated with schizophrenia." Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1381416068.

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Jin, Xiaoming. "Dendritic development of GABAergic cortical interneurons revealed by biolistic transfection with GFP." Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2626.

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Thesis (Ph. D.)--West Virginia University, 2002.<br>Title from document title page. Document formatted into pages; contains vii, 218 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
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Leclerq, Pascale. "Quantitative post-mortem study of cortical interneurons in chronic schizophrenia." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300445.

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Книги з теми "Interneurone cortical"

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Gallerani, Nicholas Edmund. The spatial distribution of cortical interneurons: The role of clustered protocadherins. [publisher not identified], 2021.

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R, Jefferys John G., and Whittington Miles A, eds. Fast oscillations in cortical circuits. MIT Press, 1999.

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Zecevic, Nada, Zsófia Maglóczky, and Filip Barinka, eds. At The Top of the Interneuronal Pyramid – Calretinin Expressing Cortical Interneurons. Frontiers Media SA, 2016. http://dx.doi.org/10.3389/978-2-88919-708-8.

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Cauli, Bruno, Yoshiyuki Kubota, and Ludovic Tricoire, eds. Cortical NO interneurons: from embryogenesis to functions. Frontiers Media SA, 2014. http://dx.doi.org/10.3389/978-2-88919-175-8.

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Traub, Roger D., John G. R. Jefferys, and Miles A. Whittington. Fast Oscillations in Cortical Circuits. MIT Press, 1999.

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Ziemann, Ulf. Pharmacology of TMS measures. Edited by Charles M. Epstein, Eric M. Wassermann, and Ulf Ziemann. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780198568926.013.0013.

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This article discusses various aspects of the pharmacology of transcranial magnetic stimulator (TMS) measures. TMS measures reflect axonal, or excitatory or inhibitory synaptic excitability in distinct interneuron circuits. TMS measures can be employed to study the effects of a drug with unknown or multiple modes of action, and hence to determine its main mode of action at the systems level of the motor cortex. TMS experiments can also study acute drug effects that may be different from chronic drug effects. TMS or repetitive TMS may induce changes in endogenous neurotransmitter or neuromodula
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Mason, Peggy. From Movement to Action. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190237493.003.0023.

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Tracts descending from motor control centers in the brainstem and cortex target motor interneurons and in select cases motoneurons. The mechanisms and constraints of postural control are elaborated and the effect of body mass on posture discussed. Feed-forward reflexes that maintain posture during standing and other conditions of self-motion are described. The role of descending tracts in postural control and the pathological posturing is described. Pyramidal (corticospinal and corticobulbar) and extrapyramidal control of body and face movements is contrasted. Special emphasis is placed on cor
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Частини книг з теми "Interneurone cortical"

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Miyoshi, Goichi, Robert P. Machold, and Gord Fishell. "Specification of GABAergic Neocortical Interneurons." In Cortical Development. Springer Japan, 2013. http://dx.doi.org/10.1007/978-4-431-54496-8_5.

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Murakami, Fujio, Daisuke Tanaka, Mitsutoshi Yanagida, and Emi Yamazaki. "Intracortical Multidirectional Migration of Cortical Interneurons." In Cortical Development: Genes and Genetic Abnormalities. John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/9780470994030.ch9.

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Cuomo, Dario, Paola Platania, Giuseppina Martella, et al. "Cholinergic Interneuron and Parkinsonism." In Cortico-Subcortical Dynamics in Parkinson¿s Disease. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-60327-252-0_7.

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Fishell, Gordon. "Perspectives on the Developmental Origins of Cortical Interneuron Diversity." In Cortical Development: Genes and Genetic Abnormalities. John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/9780470994030.ch3.

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Geiger, J. R. P., A. Roth, B. Taskin, and P. Jonas. "Glutamate-Mediated Synaptic Excitation of Cortical Interneurons." In Ionotropic Glutamate Receptors in the CNS. Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-662-08022-1_11.

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Maroof, Asif, and Stewart Anderson. "The Origins and Specification of Cortical Interneurons." In Developmental Plasticity of Inhibitory Circuitry. Springer US, 2009. http://dx.doi.org/10.1007/978-1-4419-1243-5_2.

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Murakami, Fujio. "Cell Migration Analysis of Cortical Interneurons After Electroporation." In Electroporation Methods in Neuroscience. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2459-2_6.

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Cook, Kieona, and Stewart A. Anderson. "Genesis and Migration of Cerebral Cortical Inhibitory Interneurons: An Overview." In Neuroscience in the 21st Century. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-88832-9_186.

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Cook, Kieona, and Stewart A. Anderson. "Genesis and Migration of Cerebral Cortical Inhibitory Interneurons: An Overview." In Neuroscience in the 21st Century. Springer New York, 2022. http://dx.doi.org/10.1007/978-1-4614-6434-1_186-1.

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Braz, João M., and Allan I. Basbaum. "Intraspinal Transplantation of Precursors of Cortical GABAergic Interneurons to Treat Neuropathic Pain." In Neuromethods. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2039-7_9.

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Тези доповідей конференцій з теми "Interneurone cortical"

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Pendyam, Sandeep, Dongbeom Kim, Gregory J. Quirk, and Satish S. Nair. "Acquisition of Fear and Extinction in Lateral Amygdala: A Modeling Study." In ASME 2010 Dynamic Systems and Control Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/dscc2010-4218.

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The lateral nucleus of amygdala (LA) is known to be a critical storage site for conditioned fear memory. Synaptic plasticity at auditory inputs to the dorsal LA (LAd) is critical for the formation and storage of auditory fear memories. Recent evidence suggests that two different cell populations (transient- and long-term plastic cells) are present in LAd and are responsible for fear learning. However, the mechanisms involved in the formation and storage of fear are not well understood. As an extension of previous work, a biologically realistic computational model of the LAd circuitry is develo
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Martini, Lorenzo, Roberta Bardini, and Stefano Di Carlo. "Meta-Analysis of cortical inhibitory interneurons markers landscape and their performances in scRNA-seq studies." In 2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2021. http://dx.doi.org/10.1109/bibm52615.2021.9669888.

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