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Статті в журналах з теми "Interaction membranaire"
Chevalier, N., R. Paul-Bellon, and P. Fenichel. "L’atrazine inhibe la prolifération in vitro de cellules séminomateuses humaines via une interaction entre récepteur aux estrogènes nucléaire classique (ERbeta) et membranaire non classique (GPER/GPR30)." Annales d'Endocrinologie 76, no. 4 (September 2015): 328. http://dx.doi.org/10.1016/j.ando.2015.07.102.
Повний текст джерелаMason, R. Preston, Mark W. Trumbore, and Pamela E. Mason. "Interactions biophysiques membranaires de l???amlodipine et propri??t??s antioxydantes." Drugs 59, Special Issue 2 (2000): 9–16. http://dx.doi.org/10.2165/00003495-200059992-00002.
Повний текст джерелаLavoie, Michel, Peter G. C. Campbell, and Claude Fortin. "Importance de mieux connaître les mécanismes de transport des métaux pour la prédiction de l’accumulation et de la toxicité des métaux dissous chez le phytoplancton : récentes avancées et défis pour le développement du modèle du ligand biotique." Revue des sciences de l’eau 29, no. 2 (June 6, 2016): 119–47. http://dx.doi.org/10.7202/1036544ar.
Повний текст джерелаAlonso, Florian, Pirjo Spuul, IJsbrand Kramer, and Elisabeth Génot. "Variations sur le thème des podosomes, une affaire de contexte." médecine/sciences 34, no. 12 (December 2018): 1063–70. http://dx.doi.org/10.1051/medsci/2018296.
Повний текст джерелаReboul, Emmanuelle. "Absorption lipidique et vitamines liposolubles : interactions lors de la digestion et du transport membranaire dans l’entérocyte." Cahiers de Nutrition et de Diététique 49, no. 5 (November 2014): 218–24. http://dx.doi.org/10.1016/j.cnd.2014.04.001.
Повний текст джерелаChahid, El Ghaouti, Hayat Loukili, Soufiane Tahiri, Saâd Alami Younssi, Abdelhak Majouli, and et Abderrahman Albizane. "Filtration du bleu de méthylène, du chrome hexavalent et de l'acide éthylène diamine tétracétique sur une membrane céramique d'ultrafiltration à base de ZnAl2O4−TiO2." Water Quality Research Journal 43, no. 4 (November 1, 2008): 313–20. http://dx.doi.org/10.2166/wqrj.2008.035.
Повний текст джерелаGoncalves, A., B. Meunier-Gontéro, M. Nowicki, A. Dhaussy, A. Huertas, M. J. Amiot, and E. Reboul. "P066 Interactions lipides-protéines membranaires : nouvelles données sur l’implication de SR-BI et CD36 dans l’absorption intestinale des lipides grâce la résonnance plasmonique de surface." Cahiers de Nutrition et de Diététique 48 (December 2013): S89—S90. http://dx.doi.org/10.1016/s0007-9960(13)70424-3.
Повний текст джерелаGoncalves, A., B. Meunier-Gontéro, M. Nowicki, A. Dhaussy, A. Huertas, M. J. Amiot, and E. Reboul. "P066 Interactions lipides-protéines membranaires : nouvelles données sur l’implication de SR-BI et CD36 dans l’absorption intestinale des lipides grâce la résonnance plasmonique de surface." Nutrition Clinique et Métabolisme 27 (December 2013): S89—S90. http://dx.doi.org/10.1016/s0985-0562(13)70398-4.
Повний текст джерелаCHILLIARD, Y., and A. OLLIER. "Alimentation lipidique et métabolisme du tissu adipeux chez les ruminants. Comparaison avec le porc et les rongeurs." INRAE Productions Animales 7, no. 4 (September 27, 1994): 293–308. http://dx.doi.org/10.20870/productions-animales.1994.7.4.4176.
Повний текст джерелаДисертації з теми "Interaction membranaire"
Tian, Xudong. "Etude des undécaprényl-pyrophosphate phosphatases dans la biogenèse de l’enveloppe et la physiologie bactérienne." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS531.
Повний текст джерелаThe bacterial cell envelope is composed of many polysaccharides such as the peptidoglycan and the lipopolysaccharides (LPS) that are required for survival and are involved in the interactions that the bacteria establish with their surroundings, including antimicrobial resistance and host immune system recognition. The biosynthesis of these polymers requires the translocation of the sugar sub-units across the plasma membrane, which implies an essential lipid carrier, the undecaprenyl phosphate lipid (C55-P). This lipid is generated by the dephosphorylation of its precursor, C55-PP, itself arising from either de novo synthesis or recycling. The Escherichia coli bacterial species possesses four membrane proteins (BacA, YbjG, PgpB and LpxT) exhibiting a C55-PP phosphatase activity, which all contribute redundantly to C55-P recycling. To highlight the specific physiological role of these enzymes in the cell wall biogenesis, our work was focused on the characterization of the mechanism of action, the function and the regulation of two of these phosphatases, PgpG and LpxT.The PgpB activity was characterized both in vivo and in vitro to decipher its role and ability to participate in two essential metabolic pathways, the C55-P recycling and the phosphatidylglycerol biosynthesis. We identified essential residues of PgpB involved in the hydrolysis of both natural substrates, C55-PP and PGP, and some others that function differently in the hydrolysis of these two lipids, allowing us to propose different reaction mechanisms for this enzyme. In addition, calorimetric data showed that substrate binding greatly stabilized the PgpB protein. Hypothetically, the underlying structural change would release energy allowing translocation of the lipid across the membrane. LpxT is responsible for a constitutive modification of the LPS by transferring the phosphate released from C55-PP to lipid A. Under certain environmental stresses, the LpxT activity is specifically inhibited by a small peptide (PmrR), thereby allowing other modifications of the lipid A structure to take place. We showed that the LpxT-dependent modification accounts for bile acids resistance in E. coli and is critically important for E. coli colonization in the host’s gut. LpxT constitutes a key critical control point in E. coli to resist different antimicrobial agents with opposite physical-chemical properties but which all target the LPS. In addition, we demonstrated that PmrR forms a stable complex with LpxT, but unexpectedly, this binding did not inhibit the phosphotransferase activity of the enzyme in vitro. We propose that PmrR inhibits LpxT activity in vivo by modulating its ability to interact with its protein partners that are involved in LPS biosynthesis. The biogenesis of cell wall polymers is essential for bacterial survival and structural changes in these components participate more or less specifically to the fitness and particular lifestyles of bacteria. The C55-PP phosphatases which participate actively in these processes therefore constitute interesting potential targets for new antibiotics design
Adrien, Vladimir. "Diffusion des lipides et interaction protéine-protéine dans des membranes modèles." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB033.
Повний текст джерелаBiological membranes, which divide the elements of life, are a key factor in biological processes such as signaling, transport, transmission of an nerve impulse, etc. Seen as two-dimensional fluids, the study of their physical properties could help us understand some unsolved biological mechanisms. This work focused on molecule mobility within membranes, and specifically on two essential parameters: membrane viscosity and lateral diffusion. After optimizing the Fluorescence Recovery After Photobleaching (FRAP) technique on confocal microscopes, we studied the mobility of molecules within two types of in vitro model membranes: the sponge phase made of a non-ionic surfactant (C12E5) and the giant unilamellar lipidic vesicles (GUVs). 1) Sponge phase (or L3) : after having established its phase diagram and shown that membrane proteins stay active in this phase, we measured protein mobility by Fluorescence Recovery After fringe Pattern Photobleaching (FRAPP). This allowed us to obtain the association constants of the proteins of the efflux pump OprM-MexAB involved in the resistance to antibiotics of the bacteria Pseudomonas aeruginosa. These interactions heavily depend on the degree of confinement of each protein. 2) GUVs : after having developed a simple method for the formation of GUVs, in which membrane proteins stay active, we measured the lipid diffusion by FRAP. We showed that, under certain conditions, they can move together, which explains the diversity of results in the literature. By measuring membrane viscosity by Fluorescence Lifetime Imaging Microscopy (FLIM), we also showed that viscosity should not be necessarily deduced from hydrodynamic diffusion models
Sikora, Romain. "Recyclage membranaire : rôle de la protéine MICAL-L1 et de son partenaire PACSINE3." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB179/document.
Повний текст джерелаThe recycling to the plasma membrane of receptors and lipids is tightly regulated and is essential for PM homeostasis, adhesion and cell migration. It requires small GTPase Rab proteins and their effectors. The MICAL-L1 protein, an effector of several Rabs including Rab 8, 11, 13 and 35, has been shown to play an important role in the recycling. Here, we report a novel interaction between MICAL-L1 and the BAR domain containing protein PACSIN3/Syndapin3 that contributes to generate tubular recycling endosomes. MICAL-L1 is required for the localization of PACSIN3 to endosomal membranes. Importantly, disruption of MICAL-L1/PACSIN3 interaction promotes the transferrin receptor (TfR) delivery back to the plasma membrane. The MICAL-L1/PACSIN3 complex accumulates in elongated tubules that contain transferrin carriers. The dynamic of transferrin positive endosomes segregation from MICAL-L1/PACSIN3 tubules suggests that MICAL-L1/PACSIN3 complex controls TfR recycling endosomes delivery to the plasma membrane. Our data provide novel mechanistic insights on the dynamical regulation of the plasma membrane recycling pathway
Catimel, Bruno. "Étude structurale et fonctionnelle de la glycoprotéine membranaire plaquettaire IIIb : interaction avec la thrombospondine." Lyon 1, 1991. http://www.theses.fr/1991LYO1H098.
Повний текст джерелаBersch, Beate. "Interaction peptides-membranes : etudes rmn de la conformation membranaire de neuropeptides par noe transfere." Université Louis Pasteur (Strasbourg) (1971-2008), 1992. http://www.theses.fr/1992STR13163.
Повний текст джерелаKhemaissa, Sonia. "Mécanismes d'interaction membranaire et de pénétration cellulaire de peptides vecteurs." Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS659.pdf.
Повний текст джерелаCPPs (Cell Penetrating Peptides) are peptides with cell penetration and transport faculties. These peptides, containing less than 30 amino acids, are generally cationic due to the high occurrence of basic residues and sometimes amphipatic. However, this internalization is non-selective, whatever the cell line. There are two main mechanisms for CPPs uptake: endocytosis and translocation. Endocytosis relies on cellular machinery, while translocation involves transient disruption of the lipid bilayer. Whatever the route of entry, the first step in the internalization process is always an interaction with membrane partners on the cell surface, namely lipids and glycosaminoglycans (GAGs). However, the mechanism of CPP internalization is the subject of much debate in the scientific community. The aim of this thesis was to provide keys for a better understanding of the internalization mechanism. The first step was to study the involvement of GAGs in the internalization mechanism. To investigate this point, chimeric peptides containing a GAG recognition sequence and a CPP sequence were designed. Quantification of internalization was carried out in different cell lines with variations in GAG composition and proportion. The contribution of Trp to CPP interactions was also investigated. To do so, the three Trp residues in the RW9 sequence (RRWWRRWRR-NH2) were substituted by other amino acids or by Trp analogues with different physico-chemical properties. Finally, the last part of this thesis focused on the development of new techniques for cytosolic CPPs quantification at physiological temperature, based on the complementation of luminescent proteins
Nion, Stéphane. "Interaction des lipoproteines de haute densite avec des proteines membranaires : implication dans le transport inverse du cholesterol." Lille 2, 1997. http://www.theses.fr/1997LIL2P253.
Повний текст джерелаPerier, Aurélie. "Mécanisme d'insertion membranaire du domaine de translocation de la toxine diphtérique et application à l'immunothérapie anti-tumorale." Paris, Muséum national d'histoire naturelle, 2006. http://www.theses.fr/2006MNHN0022.
Повний текст джерелаThe diphtheria toxin (DT), secreted by Corynebacterium diphtheriae, is a protein responsible for the major symptoms of diphtheria. The toxin is organized in three specialized domains: a catalytic domain, a translocation domain and a receptor binding domain. During the intoxication of a cell, the diphtheria toxin binds to a cell surface receptor, is internalized and reaches the endosome. The translocation domain (T) from the toxin interacts with the membrane of the endosome in response to the acidic pH found in this compartment. This process drives then the passage of the catalytic domain of the toxin in the cytoplasm. At acidic pH, the T domain undergoes a conformational change and adopts a partially folded state with characteristics of a molten globule state: it preserves native-like helices, looses tight packing of side chains and exposes hydrophobic clusters to the solvent. This state is competent for membrane interaction. We have found that, as the pH decreases, protonation of histidines was required for the formation of this molten globule state and membrane interaction. The interaction of the T domain with the membrane involves at least two steps. Firstly, the binding at the membrane surface involves hydrophobic interactions of the C-terminal region. Secondly, penetration into the membrane correlates with the reorganization of the N-terminal region in the membrane and is mainly driven by electrostatic interactions. This step leads to a functional inserted state. We used the T domain as a protein membrane anchor for soluble proteins. Attaching proteins to the surface of cells may have applications in biotechnology and cell engineering. Modifying cell surface should allow changing cell signalling, cell adhesion, cell recognition or cell stimulation. One application is the design of anti-cancer vaccines by attachment of cytokines. We have fused the Flt3-ligand to the N-terminus of T domain. We show that this method allows us to modify cell growth by direct contacts between cells
Kemayo, Koumkoua Patricia. "Structural characterisation of highly specific membrane protein-lipid interactions involved in cellular function." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF055/document.
Повний текст джерелаCell membranes are complex systems composed of variety of lipids that interacts with proteins to trigger cellular function. The delivery of these lipids to the right compartment is crucial for cells to work efficiently. The coat protein (COP) complex vesicles are involved in lipids traffic in the early stages of the secretory pathway. Recently, a highly specific interaction has been found between the transmembrane domain of p24 protein (p24TMD) abundant in COPI membrane and sphingomyelin C18:0. As such highly specific interaction have been reported for protein-protein and protein-nucleic acid interactions to be involved in regulation of cell functions, we decide to investigate this specific interaction. The p24TMD was obtained chemically and investigated by solid state NMR in presence of sphingomyelin with the ultimately goal to understand the function behind
El, Kirat-Chatel Karim. "Interaction de la phospholipase D avec des systèmes lipidiques biomimétiques : rôle de l'organisation membranaire sur l'activité de cette enzyme." Lyon 1, 2002. http://www.theses.fr/2002LYO10191.
Повний текст джерелаКниги з теми "Interaction membranaire"
Kamp, Jos A. F. op den 1939-, North Atlantic Treaty Organization. Scientific Affairs Division., and NATO Advanced Study Institute on Dynamics of Membrane Assembly (1991 : Cargèse, France), eds. Dynamics of membrane assembly. Berlin: Springer-Verlag, 1992.
Знайти повний текст джерелаCell Membrane Nanodomains: From Biochemistry to Nanoscopy. Taylor & Francis Group, 2014.
Знайти повний текст джерелаCambi, Alessandra, and Diane S. Lidke. Cell Membrane Nanodomains: From Biochemistry to Nanoscopy. Taylor & Francis Group, 2014.
Знайти повний текст джерелаCambi, Alessandra, and Diane Lidke. Cell Membrane Nanodomains. Taylor & Francis Group, 2021.
Знайти повний текст джерелаCambi, Alessandra, and Diane S. Lidke. Cell Membrane Nanodomains: From Biochemistry to Nanoscopy. Taylor & Francis Group, 2014.
Знайти повний текст джерелаCambi, Alessandra, and Diane Lidke. Cell Membrane Nanodomains. Taylor & Francis Group, 2014.
Знайти повний текст джерелаMato, Jose M. Phospholipid Metabolism in Cellular Signaling. Taylor & Francis Group, 2018.
Знайти повний текст джерелаMato, Jose M. Phospholipid Metabolism in Cellular Signaling. Taylor & Francis Group, 2018.
Знайти повний текст джерелаMato, Jose M. Phospholipid Metabolism in Cellular Signaling. Taylor & Francis Group, 2018.
Знайти повний текст джерелаPhospholipid Metabolism in Cellular Signaling. Taylor & Francis Group, 2017.
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