Дисертації з теми "Integrin with metal ions"
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Reinhard, Björn M. "Chemistry of microsolvated metal ions." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969739273.
Повний текст джерелаPhillips, Rosemary Helen. "Metal ions and Helicobacter pylori." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408125.
Повний текст джерелаPoteau, Xavier. "Fluorescent sensors for metal ions." Thesis, University of Central Lancashire, 2001. http://clok.uclan.ac.uk/21458/.
Повний текст джерелаOGGIANU, MARIANGELA. "Luminescent platforms for metal ions sensing." Doctoral thesis, Università degli Studi di Cagliari, 2021. http://hdl.handle.net/11584/314054.
Повний текст джерелаEbreo, Darren. "The role of metal ions in metal-on-metal total hip replacement." Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/59343/.
Повний текст джерелаBale, Simon J. "Retention-modification in HPLC using metal ions." Thesis, Loughborough University, 1988. https://dspace.lboro.ac.uk/2134/27578.
Повний текст джерелаNdifor-Angwafor, Nche George. "Analysis of metal ions in nanoparticle growth." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443661.
Повний текст джерелаSkipper, N. "The alkali metal ions in aqueous solutions." Thesis, University of Bristol, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379533.
Повний текст джерелаIrikura, Karl K. Beauchamp Jesse L. "Gas-phase chemistry of organotransition metal ions /." Diss., Pasadena, Calif. : California Institute of Technology, 1991. http://resolver.caltech.edu/CaltechETD:etd-06202007-111048.
Повний текст джерелаCheng, Jing. "Characterisation of wool treated with metal ions." Thesis, Queensland University of Technology, 1993. https://eprints.qut.edu.au/227117/1/T%28S%29%2025_Cheng_1993.pdf.
Повний текст джерелаGranzotto, Alberto. "Role of metal ions dyshomeostasis in neurodegeneration." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423606.
Повний текст джерелаIl presente lavoro di tesi si è suddiviso in due filoni principali che hanno come filo conduttore la disomeostasi di ioni metallici nei processi neurodegenerativi. La prima parte riporta lo studio sul ruolo di alcuni ioni metallici (alluminio, ferro, rame e zinco) nel processo di folding della proteina β-amiloide (Aβ), ritenuta uno dei fattori eziopatogenici del morbo di Alzheimer. I dati ottenuti dimostrano come i complessi Aβ-metallo-ione acquistino una peculiare conformazione dipendente dal metallo legato, conferendo così all’Aβ particolari proprietà citotossiche. Tale citotossicità risulta particolarmente evidente per il complesso Aβ-Al che è in grado di aumentare, in maniera significativa, la tossicità data dalla sola Aβ o dalla stessa Aβ coniugata con metalli diversi dall’Al. All’interno di questo quadro sperimentale si è poi cercato di indagare più nel dettaglio i meccanismi con i quali Aβ, e i suoi complessi metallici, esercitassero la loro citotossicità. A questo scopo sono stati impiegati due composti quali il resveratrolo e il colesterolo, che vanno ad agire su due meccanismi che stanno alla base della tossicità dell’Aβ, come lo stress ossidativo e l’alterata fluidità delle membrane cellulari. Nel primo caso, i dati in vitro hanno permesso di dimostrare come, agendo in maniera selettiva sulla produzione di specie reattive dell’ossigeno (ROS) Aβ-mediata, sia possibile ridurre la tossicità di Aβ e dei suoi complessi con metalli redox (rame e ferro) mediante un meccanismo di scavenging dei ROS ad opera del resveratrolo, dalle spiccate proprietà anti-ossidanti e neuro-protettive. A questo punto si è indagata la capacità dei vari complessi Aβ-metalloioni di alterare la struttura di membrane lipidiche attraverso l’uso di modelli di membrane cellulari. In precedenza si era dimostrato come il complesso Aβ-Al fosse l’unico complesso in grado di alterare significativamente la fluidità di layer lipidici. I dati ottenuti ci permettono di affermare che tale capacità è dovuta principalmente alla elevata idrofobicità superficiale del complesso Aβ-Al. Inoltre, agendo sulle membrane cellulari con concentrazioni fisiologiche di colesterolo è stato possibile ridurre l’”irrigidimento” delle membrane (lipidico) conseguente alla presenza di Aβ-Al, e ridurne la citotossicità. Si é quindi approfondito il ruolo geno-tossico dei succitati complessi Aβ-metalloioni andando ad indagare come questi siano in grado di modulare in maniera significativa (e metallo-dipendente) l’espressione genica di numerosi trascritti coinvolti nella patologia di Alzheimer. In particolare, il nostro interesse si è focalizzato sui complessi Aβ-Cu e Aβ-Zn, che si sono rivelati in grado di modulare selettivamente l’espressione di geni coinvolti in processi infiammatori, nello stress ossidativo e nella morte cellulare (apoptosi). Dopo questa serie di studi in vitro si è passati ad indagare l’espressione genica dell’intero genoma umano in un modello in vivo di patologia di Alzheimer. Lo scopo era quello di identificare il network o il pathway d’espressione coinvolti della disomeostasi cationica. I profili d’espressione del modello murino 3xTg-AD sono stati pertanto confrontati con quelli del controllo wild type. In questo contesto, si è scoperta una significativa sovrapposizione dei geni sovra- e sotto-espressi tra topi wild type anziani e topi 3xTg-AD giovani. Questo dato supporta l’idea che il substrato patologico dell’AD possa favorire un processo di invecchiamento precoce. All’interno del gruppo di geni trovati differenzialmente espressi, molti erano coinvolti nell’omeostasi del calcio, ione chiave per la fisiopatologia cellulare. Il secondo filone di ricerca ha riguardato lo studio del ruolo dello ione calcio nell’eccitotossicità dei neuroni dello striato. Tale fenomeno è particolarmente importante in alcune patologie neurodegenerative che hanno come segno caratteristico una progressiva e irreversibile perdita del controllo motorio, come ad esempio il morbo di Huntington. L’interesse si è focalizzato nel determinare il perchè una subpopolazione di neuroni striatali, caratterizzata dalla sovraespressione di nitrico-ossidosintasi, non vada incontro ad apoptosi in seguito a stress eccitotossico. I dati raccolti ci hanno permesso di stabilire che la resistenza di tale sottopopolazione al sovraccarico di calcio è dovuta principalmente ad una potenziata capacità di questi neuroni di detossificarsi rapidamente dalle specie ROS, di origine mitocondriale, specie che si generano durante fenomeni eccitotossici. Conclusione. Nel complesso i dati ottenuti sottolineano una volta di più un ruolo centrale degli ioni metallici nello sviluppo e/o nella progressione di alcune patologie a carattere neurodegenerativo. In particolare è importante notare come, a fianco di alcuni ioni metallici endogeni - che hanno un rilevante ruolo fisiologico (ferro, rame, zinco, calcio) -, anche altri ioni privi (apparentemente) di un ruolo biologico, ma coi quali ci interfacciamo quotidianamente, come ad esempio l’alluminio, sembrino svolgere un ruolo chiave in processi eziopatogenetici legati a fenomeni neurodegenerativi
Chen, Wan-Ru. "Interactions of tetracycline antibiotics with dissolved metal ions and metal oxides." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24698.
Повний текст джерелаCommittee Chair: Huang, Ching-Hua; Committee Member: Kim, Jaehong; Committee Member: Pavlostathis, Spyros; Committee Member: Stack, Andrew; Committee Member: Yiacoumi, Sotira
Lentz, Nicholas B. "Electrospray ionization mass spectrometry from cluster ions to toxic metal ions in biology /." [Ames, Iowa : Iowa State University], 2007.
Знайти повний текст джерелаBalteanu, Iulia. "FT-ICR studies of transition metal cluster ions." [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974430919.
Повний текст джерелаSmith, Alexis. "Coordination complexes of trivalent non-transition metal ions." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28400.
Повний текст джерелаScience, Faculty of
Chemistry, Department of
Graduate
Abbasi, Alireza. "Structural and Spectroscopic Studies of Solvated Metal Ions." Doctoral thesis, Stockholm : Structural Chemistry, Arrhenius Laboratory, Stockholm university, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-446.
Повний текст джерелаCao, Yu. "Mass spectrometric study of alkali metal containing ions." Diss., Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/27890.
Повний текст джерелаGernert, Ina [Verfasser]. "Redox Chemistry of Hydrated Metal Ions / Ina Gernert." Kiel : Universitätsbibliothek Kiel, 2018. http://d-nb.info/1173163182/34.
Повний текст джерелаLow, Wan Li. "Lipsome encapsulated antimicrobial metal ions and essential oils." Thesis, University of Wolverhampton, 2012. http://hdl.handle.net/2436/219012.
Повний текст джерелаSameera, W. M. C. "Electronic structure of transition metal ions and clusters." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/1389/.
Повний текст джерелаCrabtree, Elaine. "The role of metal ions in LDL peroxidation." Thesis, Birkbeck (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266211.
Повний текст джерелаLloyd, Bryony Helen. "Bacterial resistance to tellurite and other metal ions." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333673.
Повний текст джерелаDey, Benu Kumar. "A study on metal ion complexation with a macrocyclic ligand : a thermodynamic, kinetic, and mechanistic investigation." Title page, contents and abstract only, 1991. http://web4.library.adelaide.edu.au/theses/09SM/09smd528.pdf.
Повний текст джерелаPalla, Veladri. "Heterometallic Interactions of d8-d10 Metal Ions in the Presence of +2 Cations." Fogler Library, University of Maine, 2007. http://www.library.umaine.edu/theses/pdf/PallaV2007.pdf.
Повний текст джерелаXia, Baohui, and 夏寶輝. "Metal-metal interactions in homo- and hetero-metallic complexes containing d0, d8 and d10 metal ions: spectroscopic and theoretical studies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B42577317.
Повний текст джерелаXia, Baohui. "Metal-metal interactions in homo- and hetero-metallic complexes containing d0, d8 and d10 metal ions spectroscopic and theoretical studies /." Click to view the E-thesis via HKUTO, 2002. http://sunzi.lib.hku.hk/hkuto/record/B42577317.
Повний текст джерелаLiu, Haichuan. "Reactions in gaseous metal-organic complexes induced by the photoexcitation of the metal chromaphores /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202004%20LIU.
Повний текст джерелаMayr, Torsten. "Optical sensors for the determination of heavy metal ions." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964444569.
Повний текст джерелаHetzer, Adrian. "Sequestration of metal and metalloid ions by thermophilic bacteria." The University of Waikato, 2007. http://hdl.handle.net/10289/2642.
Повний текст джерелаSeo, Jin Seog. "Hydrolyzing phosphates with metal ions : di and trinuclear approach." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq30381.pdf.
Повний текст джерелаOuyang, Hui. "Calmodulin interactions with peptides, hormones, drugs and metal ions." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0025/NQ49528.pdf.
Повний текст джерелаAger, Patrick. "Mobilizationpurging of aqueous metal ions into supercritical carbon dioxide." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=20553.
Повний текст джерелаTobin, John M. (John Michael). "The uptake of metal ions by rhizopus arrhizus biomass /." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=73999.
Повний текст джерелаTaylor, T. M. C. "Modified phospholipids : Oxidation promoted by vesicle-bound metal ions." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382664.
Повний текст джерелаShackleford, Stephen. "Development of an EQCM-based sensor for metal ions." Thesis, University of Central Lancashire, 2002. http://clok.uclan.ac.uk/8090/.
Повний текст джерелаDobson, Matthew Peter. "Studies of singly and doubly charged solvated metal ions." Thesis, University of Sussex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321352.
Повний текст джерелаKwon, Yeong Kun. "Chemistry of some complexes containing biologically significant metal ions." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46401.
Повний текст джерелаBotelho, Hugo M. "Metal ions and protein folding: conformational and functional interplay." Doctoral thesis, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2010. http://hdl.handle.net/10362/5151.
Повний текст джерелаMetal ions are cofactors in about 30% of all proteins, where they fulfill catalytical and structural roles. Due to their unique chemistry and coordination properties they effectively expand the intrinsic polypeptide properties (by participating in catalysis or electron transfer reactions), stabilize protein conformations (like in zinc fingers) and mediate signal transduction (by promoting functionally relevant protein conformational changes). However, metal ions can also exert have deleterious effects in living systems by incorporating in non-native binding sites, promoting aberrant protein aggregation or mediating redox cycling with generation of reactive oxygen and nitrogen species. For this reason, the characterization of the roles of metal ions as modulators of protein conformation and stability provides fundamental knowledge on protein folding properties and is instrumental in establishing the molecular basis of disease. In this thesis we have analyzed protein folding processes using model protein systems incorporating covalently bound metal cofactors – iron-sulfur (FeS) proteins – or where metal ion binding is reversible and associated conformational readjustments – the S100 proteins.(...)
Lawrence, Helen. "Cellular recognition of metal ions and mechanisms of reactivity." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3323.
Повний текст джерелаCa, Diep Vu. "NANOSTRUCTURED ASSEMBLIES FOR SOLID PHASE EXTRACTION OF METAL IONS." Miami University / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=miami1107552000.
Повний текст джерелаXiao, Kexing. "Deprotonation Property of Polyoxometalates with Different Lacunary Metal Ions." University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron155534024745702.
Повний текст джерелаNaqvi, Kazim Raza. "Role of transition metal ions in oxidative hair colouring." Thesis, University of York, 2014. http://etheses.whiterose.ac.uk/6955/.
Повний текст джерелаSavage, Chandra Shannon. "Ions, isotopes, and metal cyanides: Observational and laboratory studies." Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/290082.
Повний текст джерелаBaker, Douglas Hugh. "Formation and desorption of negative ions from metal surfaces." W&M ScholarWorks, 1992. https://scholarworks.wm.edu/etd/1539623825.
Повний текст джерелаSchilling, J. Bruce Goddard William A. Beauchamp Jesse L. "Experimental and theoretical aspects of hydrocarbon activation by transition metal ions in the gas phase." Diss., Pasadena, Calif. : California Institute of Technology, 1987. http://resolver.caltech.edu/CaltechTHESIS:11062009-094101367.
Повний текст джерелаAdvisor names found in the Acknowledgements pages of the thesis. Title from home page. Viewed 01/15/2010. Includes bibliographical references.
Chen, Yongsheng. "Synthesis and properties of benzannulenes and their metal complexes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0013/NQ32706.pdf.
Повний текст джерелаTkaczyk, Cathy. "Ions released from metal-on-metal hip implants: «in vitro» and «in vivo» investigations." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86703.
Повний текст джерелаDe nombreuses études ont montré que les particules et ions métalliques (Cr(III), Co(II) et Cr(VI)) générés par l'usure de prothèses de hanche métalliques (PHM) se retrouvent dans le flux sanguin des patients et s'accumulent également dans leurs tissus et leurs organes. Ces ions peuvent génèrer des radicaux libres qui peuvent à leur tour être nocifs pour la cellule. Nous avons déterminé les effets de ces ions sur les enzymes antioxidantes (SODs, CAT, GPx, HO-1) qui représentent la première ligne de défense cellulaire contre les radicaux libres. Nos travaux ont révélé que le Cr(VI) induit l'expression de ces protéines (traduction) mais non l'expression de leur ARNm (transcription). Le Co(II) induit l'expression de la proteine et de l'ARNm de HO-1 seulement alors que le Cr(III) n'a aucun effet sur l'expression de ces enzymes. Nous avons par la suite suggéré, que la structure moléculaire de ces ions pouvait avoir une influence sur leurs différents effets. Les résultats ont montré que le Cr(III) formait des complexes constitués d'une partie organique (acides aminés et phosphates) et d'une partie inorganique (Cr, calcium et sodium), alors que ni le Co(II), ni le Cr(VI) ne formaient de complexes dans les mêmes conditions expérimentales. En présence de sérum bovin fétal, les complexes de Cr(III) pouvent se lier seulement à l'albumine, alors qu'en présence de sérum humain, ces mêmes complexes intéragissent avec 8 protéines de nature differente. Cette intéraction avec les protéines humaines semble augmenter l'internalisation des complexes par les macrophages. Finalement, les résultats démontrent que la concentration d'ions Co et Cr présents dans le sang de patients portant une PHM est insuffisante pour induire un stress oxydant et apportent un souffle optimiste sur les effets à long terme des ions métalliques chez les patients. Dans son ensemble ce projet apporte de nouveaux éléments de connaissances sur les effets biologiq
Martinez, Ortega Maria Eugenia. "Lipid metal organic networks." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2009. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.
Повний текст джерелаCruz, González Sara. "Availability of metal ions and ZnO nanoparticles in aqueous media." Doctoral thesis, Universitat de Lleida, 2015. http://hdl.handle.net/10803/314762.
Повний текст джерелаLa presencia de determinados metales, ya sea en forma del metal libre, formando complejos con ligandos o en forma de nanopartículas metálicas tiene efectos negativos en el medio ambiente. Por este motivo, el estudio de la disponibilidad de metales es importante para determinar su impacto medioambiental. En este trabajo se ha estudiado un sistema y una técnica para la medida de la disponibilidad. El sistema tiene la particularidad de contener, en dispersión, nanopartículas de óxidos metálicos. Una primera parte del estudio se enfoca a la caracterización físico-química de dispersiones sintéticas de nanopartículas. Esta parte estudia el efecto que tienen las condiciones del medio (pH, salinidad, contenido de materia orgánica, etc) en el comportamiento de las nanopartículas. Se han determinado procesos como son la agregación, solubilidad y sedimentación, en función de las condiciones del medio. Todos estos procesos juegan un papel muy importante en el destino de las nanopartículas en el medio ambiente y en su toxicidad. La segunda parte de esta tesis se centra en la aplicación de la técnica analítica DGT (Diffusive Gradiente in Thin films) para la medida de flujos de metal disponibles en soluciones acuosas. En el presente trabajo, se ha determinado la solubilidad de nanopartículas en dispersiones acuosas. Por otra parte se ha estudiado la técnica DGT desde un punto de vista físico-químico. Las contribuciones de los flujos de complejos se evalúan con un parámetro que tiene en cuenta las constantes de disociación de los complejos así como su difusión. Se han estudiado las acumulaciones de metales que en solución tienen como especies dominantes complejos cargados eléctricamente. Si esta carga es negativa, la acumulación disminuye al bajar la fuerza iónica y viceversa en el caso contrario. Este fenómeno se explica por la repulsión electrostática entre la carga negativa del disco de resina y el complejo cuando éste es parcialmente lábil. En conclusión, la resina parece jugar un papel más activo de lo que se pensaba en la acumulación de metales en DGT.
The presence of certain metals, either in the form of free metal, forming complexes with ligands or as metal nanoparticles has negative effects on the environment. For this reason, the study of the availability of metals is important in determining its environmental impact. In this work a system and a technique for measuring availability have been studied. The system contains, in dispersion, metal oxide nanoparticles. A first part of the study focuses on the physical and chemical characterization of synthetic dispersions of nanoparticles. This part examines the effect of environmental conditions (pH, salinity, organic matter content, etc.) in the behavior of nanoparticles. Processes such as aggregation, solubilisation and sedimentation, are determined depending on environmental conditions. All these processes play an important role in the fate of nanoparticles in the environment and their toxicity. The second part of this thesis focuses on the application of the analytical technique DGT (Diffusive Gradient in Thin films) for measuring the flow of available metals in aqueous solutions. In the present study, the solubility of nanoparticles in aqueous dispersions has been determined. Moreover the DGT technique has been studied from a physical-chemical point of view. The contribution of the flux of complexes has been evaluated with a parameter, the lability degree, which takes into account the dissociation constants of the complexes and their diffusion. The accumulations of metals which in solution are present as dominant metal complexes electrically charged have been studied. If the charge is negative, the accumulation decreases with the decrease of the ionic strength and vice versa in the opposite case. This phenomenon is explained by the electrostatic repulsion between the negatively charged resin disk and the complex when it is partially labile. In conclusion, the resin seems to play a more active role than previously thought in the accumulation of metals in DGT.
Luo, Ming. "Transition-metal ions in II-VI semiconductors ZnSe and ZnTe /." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4630.
Повний текст джерелаTitle from document title page. Document formatted into pages; contains xiv, 141 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 135-141).