Дисертації з теми "Integrin alpha 5"
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Zimmermann, Dunja. "Der Einfluss cyclischer RGD-Peptide auf die Wechselwirkung Fibronectin-Integrin [alpha]5[beta]1[alpha 5 beta 1]." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=970414277.
Повний текст джерелаKünneken, Kerstin. "Rekombinante Mini-Laminin-5-Proteine zur Charakterisierung der 3 1-Integrin-Bindung [Alpha-3-Beta-1-Integrin-Bindung]." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967391334.
Повний текст джерелаNguyen, Beth P. "Integrin alpha 6 beta 4 ligation to laminin 5 and phosphoinositide 3-OH kinase define differences in alpha 3 beta 1-laminin 5 and alpha 2 beta 1-collagen spreading : implications for epidermal wound repair /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/9286.
Повний текст джерелаSiller-Jackson, Arlene J. "Connexin 43 hemichannels are regulated by mechanical stress and [alpha]5 integrin in osteocyte-like cells : a dissertation /." San Antonio : UTHSC, 2007. http://proquest.umi.com/pqdweb?did=1400962241&sid=1&Fmt=2&clientId=70986&RQT=309&VName=PQD.
Повний текст джерелаMysinger, Cynthia. "CAR is not required for adenovirus infection: Integrin alpha v beta 5 mediates binding to CAR-negative cells." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3359557.
Повний текст джерелаVignoud, Lucile. "Étude du rôle des motifs NPXY dans la fonction de l'intégrine alpha 5/beta 1." Grenoble 1, 1996. http://www.theses.fr/1996GRE10274.
Повний текст джерелаParks, William. "Force activation of I domain containing and lacking integrins on live cells." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/42695.
Повний текст джерелаQuinn, Jeffrey Alan. "Requirement of integrin [alpha]5[beta]1 and tyrosine phosphorylation of SHC for prohb-EGF release by GPR30, a seven transmembrane receptor for estrogen /." View online ; access limited to URI, 2006. http://0-wwwlib.umi.com.helin.uri.edu/dissertations/dlnow/3225328.
Повний текст джерелаKaufmann, Martin. "Lipid Bilayers Supported by Multi-Stimuli Responsive Polymers." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-106231.
Повний текст джерелаRoger, Patrica. "Role des integrines et des asialogangliosides dans les mecanismes d'adherence bacterienne a l'epithelium respiratoire." Reims, 1998. http://www.theses.fr/1998REIMM201.
Повний текст джерелаBouvard, Daniel. "Identification d'une voie de signalisation controlant l'adhérence cellulaire dépendante de l'intégrine [alpha]5[bêta]1." Université Joseph Fourier (Grenoble), 1999. http://www.theses.fr/1999GRE10158.
Повний текст джерелаGuimarães, Camila Rennó. "Caracterização fenotípica da população de células T reguladoras em sangue de cordão umbilical de recém-nascidos a termo e pré-termo." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-03022016-152322/.
Повний текст джерелаThe predisposition of newborn infants to infectious diseases is attributed, in part, to the lack of pre-existing immunological memory. In preterm newborns, it is assumed that the immune system is less developed at birth, but little is known about the size and characteristics of lymphocyte subpopulations. Regulatory T cells (Tregs) have a crucial role in controlling the development of a healthy immune system including the maintenance of self-tolerance and, their absence, is responsible for the range of inflammatory and autoimmune manifestations observed in patients with IPEX (Immunodysregulation Polyendocrinopathy Enteropathy X-linked Syndrome). These cells are phenotypically characterized by the presence of the transcription factor Foxp3 (forkhead box P3) and by the high expression of the ? chain of the IL-2 receptor (CD25), as this cytokine is essential for the generation, maintenance and function of Treg cells. Little is known about the frequency of these cells in neonates, particularly in very and moderate preterm newborns and late preterm newborns studied as separate groups. Preliminary results from our group revealed greater ability of newborns to produce proinflammatory response compared to adults, which was further accentuated by the decreased production of IL-10, which suggests a reduced regulatory function. Thus, the aim of this study was to phenotypically characterize and quantify the population of Treg cells, by flow cytometry, in the cord blood of 15 preterm newborns born at 30-336/7 gestation weeks (Group 1), 19 preterm newborns born at 34-366/7 gestation weeks (Group 2) and 20 term newborns born at 37-41 gestation weeks (Group 3), all clinically healthy and adequate-for-gestational-age, compared to 26 healthy adults. The results demonstrated that there is an inverse correlation of the Treg frequency and gestational age, with significantly higher frequencies of CD4+CD25hiCD127loFoxp3+ Treg cells in Group 1 compared to Groups 2 and 3 and in Group 2 compared to Group 3, as well as significantly higher Treg frequencies and numbers in all the neonates compared to the adults. All of the newborns exhibited increased Treg frequencies with a naive phenotype compared to the adults. CTLA-4 expression in the naive Tregs was decreased in both preterm groups compared with those from term newborns and adults, as well as in the memory Treg cells from Group 1 compared with the other groups. The frequencies of alfa4beta7+ and alfa4beta1+ Tregs were higher in both preterm groups, but significantly different only in Group 1, when compared with those from the term newborns and the adults. In conclusion, high frequencies of Tregs were observed in term and preterm newborns, and these frequencies showed an inverse correlation with gestational age. These cells exhibited a naive profile when compared with adults, with high expression of CD45RA and alfa4beta7+ and lower expression of CTLA-4, implying a decreased function, particularly in very preterm newborns
Brückner, Juliane. "Die regulatorische Beeinflussung der spezifischen Interaktion von Endothelzellen und Staphylococcus aureus über den Fibronektinrezeptor alpa 5 beta 1 -Integrin am rechten und linken Herzen." kostenfrei, 2009. http://mediatum2.ub.tum.de/node?id=681034.
Повний текст джерелаKünneken, Kerstin [Verfasser]. "Rekombinante Mini-Laminin-5-Proteine zur Charakterisierung der 3 1-Integrin-Bindung [Alpha-3-Beta-1-Integrin-Bindung] / vorgelegt von Kerstin Künneken." 2002. http://d-nb.info/967391334/34.
Повний текст джерелаBeauvais, DeannaLee Marie. "Syndecan-1 regulates [alph](v)[beta](3) and [alpha](v)[beta](5)integrin activity via the ectodomain of its core protein." 2005. http://catalog.hathitrust.org/api/volumes/oclc/71242463.html.
Повний текст джерелаZimmermann, Dunja [Verfasser]. "Der Einfluß cyclischer RGD-Peptide auf die Wechselwirkung Fibronectin-Integrin α5β1[alpha 5 beta 1] / vorgelegt von Dunja Zimmermann". 2004. http://d-nb.info/970414277/34.
Повний текст джерелаBrückner, Juliane [Verfasser]. "Die regulatorische Beeinflussung der spezifischen Interaktion von Endothelzellen und Staphylococcus aureus über den Fibronektinrezeptor α5β1-Integrin [Alpha-5-beta-1-Integrin] am rechten und linken Herzen / Juliane Brückner". 2009. http://d-nb.info/996056874/34.
Повний текст джерелаKaufmann, Martin. "Lipid Bilayers Supported by Multi-Stimuli Responsive Polymers." Doctoral thesis, 2012. https://tud.qucosa.de/id/qucosa%3A26659.
Повний текст джерелаHeckmann, Dominik [Verfasser]. "Design and synthesis of selective ligands for the α5β1 [alpha-5-beta-1] integrin receptor and cyclic peptides as affinity ligands for factor VIII purification / Dominik Heckmann". 2007. http://d-nb.info/988082853/34.
Повний текст джерелаLiu, Yu-Chen, and 劉祐禎. "Structural Determinants of Integrins alpha v beta 3 and alpha 5 beta 1 Recognition by Rhodostomin Mutants." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/g5j3p2.
Повний текст джерела國立成功大學
生物化學研究所
92
Integrins are a family of cell surface receptors that mediate cell cellular adhesion, cell migration and signal transduction. It is known that integrins play important roles in the initiation and progression of many common diseases. Therefore, antagonism of integrins provides an approach for the treatment and prevention of these diseases. The RGD sequence is the cell attachment site of a large number of adhesive ECM, blood, and cell surface proteins and nearly half of 24 known integrins recognize this sequence in their adhesive ligands. Many studies have showed that the amino acid residues flanking the RGD motif of snake venom disintegrins control their binding specificity. Rhodostomin (Rho) is a potent integrin inhibitor and contains a PRGDMP sequence at positions of 48-53. Based on our results of cell adhesion analyses, we found that Rho mutants containing either ARGDGP or PRGDGP sequence can selectively inhibit integrin alpha v beta 3 and Rho mutants containing ARGDXP sequence in the RGD loop have better inhibitory activity to integrin alpha 5 beta 1. To understand structural determinants of integrins alpha v beta 3 and alpha 5 beta 1 recognition, we have determined 3D structures of these mutant proteins (ARGDMP, ARGDNP, ARGDGP and PRGDGP) by using NMR spectroscopy. Based on our structural analyses, the tertiary folds of wild-type and mutant proteins are the same. However, the backbone conformation of the RGD loop and the side-chain orientation of the D51 residue of mutant proteins (ARGDGP and PRGDGP) differ from those of wild-type Rho. Their structures are similar to our reported structure of the ARGDDL mutant, an integrin alpha v beta 3-specific protein. These results suggest that these conformational differences may be responsible for their inhibitory selectivity to integrin alpha v beta 3. In addition, model-free analyses of PRGDMP and ARGDMP proteins reveal that mutation of P48 to A caused a decrease in the order parameter (S2) of the R49 residue of the ARGDMP protein, mainly due to the decrease of R2. This difference may be responsible for the better inhibitory activity of Rho mutants containing ARGDXP sequence to integrin alpha 5 beta 1. Using 3D structure of alpha v beta 3 integrin as template, 3D model structures of integrins alpha IIb beta 3 and alpha 5 beta 1 were generated by using homology modeling. Docking integrins alpha IIb beta 3, alpha v beta 3, and alpha 5 beta 1-specific Rho mutants to their receptors will be used to identify their possible interacting amino acids. Our findings suggest that the residues flanking the RGD motif of disintegrins regulate their structure, dynamics and function. These results will be used to design potent integrins alpha IIb beta 3, alpha v beta 3, and alpha 5 beta 1-specific antagonists.
Künzel, Franziska [Verfasser]. "Generierung von Antikörper-Bibliotheken und Selektion von Antikörpern gegen die Integrine αvβ5 [Alpha v Beta 5] und αβ1 [Alpha 5 Beta 1] mittels Phagen-Display-Technologie / vorgelegt von Franziska Künzel". 2008. http://d-nb.info/999485571/34.
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