Дисертації з теми "Insulin Analysis"
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Raab, R. Michael. "Genomic analysis of hepatic insulin resistance." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33762.
Повний текст джерелаIncludes bibliographical references (leaves 159-191).
Type II Diabetes mellitus is a genetically complex disease characterized by insulin resistance in peripheral tissues, which results in simultaneous hyperglycemia and hyperinsulinemia. Because of the prevalence of type II diabetes, many researchers are investigating the genetics of glucose homeostasis, however, traditional mapping techniques have not been successful in determining all of the genes that regulate glycemia. To complement these efforts, we used DNA microarrays to find differentially expressed genes and combinatorial siRNA screening to investigate the effects of hepatic gene transcription during periods of high and low glucose production. This strategy provides a new approach to studying the molecular mechanisms of disease pathogenesis. Our investigations focused on discovering new genes that influence hepatic metabolism and glucose production. Hepatocytes help maintain whole body glycemia by providing glucose and other substrates during non-feeding periods. DNA microarrays containing 17,000 unique gene probes were used to study hepatic gene transcription during normal, insulin resistant, and fasting states in C57/BL/6J mice. We analyzed this data set using a combination of statistical and multivariate techniques to determine 41 different, genes that are differentially expressed and highly discriminatory of the treatment groups.
(cont.) Hepatocytes perform many physiological roles, thus to investigate which genes from the microarray analysis affected hepatic metabolism, we developed combinatorial RNA-interference (RNAi) based gene silencing techniques. Using combinatorial siRNA screening, we silenced genes that were over-expressed within the microarray data set to study loss of function effects on hepatic metabolism, which was quantified by measuring intracellular metabolite concentrations in relevant metabolic pathways. Based upon the metabolite dependent clustering of experimental and control samples using Fisher Discriminant Analysis, four of the silenced genes had a significant effect on key metabolites involved in hepatic glucose output. Of these four genes, three were shown to influence hepatic glucose output in our primary cell model.
by R. Michael Raab.
Ph.D.
James, Declan Jonathan. "An analysis of insulin- and non-insulin- stimulated glucose transport in rat skeletal muscle." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394962.
Повний текст джерелаKaizik, Stephan Martin. "Analysis of mouse models of insulin secretion disorders." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:4d44b68a-a0a0-4c92-8809-00ddbfe3e636.
Повний текст джерелаHernández, Adrian V., Mirella Guarnizo, Yony Miranda, Vinay Pasupuleti, Abhishek Deshpande, Socorro Paico, Hosten Lenti, et al. "Association between Insulin Resistance and Breast Carcinoma: A Systematic Review and Meta-Analysis." Public Library of Science (PLoS), 2014. http://hdl.handle.net/10757/320267.
Повний текст джерелаObjective: This study was undertaken to evaluate the association between components defining insulin resistance and breast cancer in women. Study Design: We conducted a systematic review of four databases (PubMed-Medline, EMBASE, Web of Science, and Scopus) for observational studies evaluating components defining insulin resistance in women with and without breast cancer. A meta-analysis of the association between insulin resistance components and breast cancer was performed using random effects models. Results: Twenty-two studies (n = 33,405) were selected. Fasting insulin levels were not different between women with and without breast cancer (standardized mean difference, SMD 20.03, 95%CI 20.32 to 0.27; p = 0.9). Similarly, non-fasting/ fasting C-peptide levels were not different between the two groups (mean difference, MD 0.07, 20.21 to 0.34; p = 0.6). Using individual odds ratios (ORs) adjusted at least for age, there was no higher risk of breast cancer when upper quartiles were compared with the lowest quartile (Q1) of fasting insulin levels (OR Q2 vs. Q1 0.96, 0.71 to 1.28; OR Q3 vs. Q1 1.22, 0.91 to 1.64; OR Q4 vs. Q1 0.98, 0.70 to 1.38). Likewise, there were no differences for quartiles of non-fasting/fasting C-peptide levels (OR Q2 vs. Q1 1.12, 0.91 to 1.37; OR Q3 vs. Q1 1.20, 0.91 to 1.59; OR Q4 vs. Q1 1.40, 1.03 to 1.92). Homeostatic model assessment (HOMAIR) levels in breast cancer patients were significantly higher than in people without breast cancer (MD 0.22, 0.13 to 0.31, p, 0.00001). Conclusions: Higher levels of fasting insulin or non-fasting/fasting C-peptide are not associated with breast cancer in women. HOMA-IR levels are slightly higher in women with breast cancer.
Pretty, Christopher Grant. "Analysis, classification and management of insulin sensitivity variability in a glucose-insulin system model for critical illness." Thesis, University of Canterbury. Mechanical Engineering, 2012. http://hdl.handle.net/10092/6580.
Повний текст джерелаReed, Peter Wayne. "Genetic analysis of Type 1 (insulin-dependent) diabetes mellitus." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325788.
Повний текст джерелаPearson, James. "Analysis of the repertoire of insulin-reactive CD8+ T cells." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/68395/.
Повний текст джерелаThota, P., F. R. Perez-Lopez, Vicente A. Benítes-Zapata, V. Pasupuleti, and Adrian V. Hernandez. "Obesity-related insulin resistance in adolescents: a systematic review and meta-analysis of observational studies." Taylor and Francis Ltd, 2017. http://hdl.handle.net/10757/622281.
Повний текст джерелаInsulin resistance is common among obese adolescents; however, the extent of this problem is not clear. We conducted a systematic review of PubMed-Medline, CINAHL, The Web of Science, EMBASE and Scopus for observational studies evaluating components defining insulin resistance (insulin, C-peptide and homeostatic model assessment-insulin resistance [HOMA-IR]) in obese adolescents (12–18 years) versus non-obese adolescents. Our systematic review and meta-analysis followed the PRISMA guidelines. Data were combined using a random-effects model and summary statistics were calculated using the mean differences (MDs). 31 studies were included (n = 8655). In 26 studies, fasting insulin levels were higher in obese adolescents when compared to non-obese adolescents (MD = 64.11 pmol/L, 95%CI 49.48–78.75, p < 0.00001). In three studies, fasting C-peptide levels were higher in obese adolescents when compared to non-obese adolescents (MD = 0.29 nmol/L, 95%CI 0.22–0.36, p < 0.00001). In 24 studies, HOMA-IR values were higher in obese adolescents when compared to non-obese adolescents (MD = 2.22, 95%CI 1.78–2.67, p < 0.00001). Heterogeneity of effects among studies was moderate to high. Subgroup analyses showed similar results to the main analyses. Circulating insulin and C-peptide levels and HOMA-IR values were significantly higher in obese adolescents compared to those non-obese.
Revisión por pares
Derewenda, Urszula. "X-ray analysis of dimeric and hexameric insulins." Thesis, University of York, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276517.
Повний текст джерелаLunt, Helen. "Analysis of a system used to detect islet cell stimulating antibodies." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385080.
Повний текст джерелаEriksson, Susanne Elisabeth. "To live with insulin dependent diabetes." Thesis, Mälardalens högskola, Akademin för hälsa, vård och välfärd, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-41014.
Повний текст джерелаCARVALHO, Dayse Cabral de. "Custo-utilidade da insulina glargina e insulina isófana (NPH) para o tratamento de pacientes com diabetes mellitus tipo 2 atendidos no Sistema Único de Saúde do Município de Recife." Universidade Federal de Pernambuco, 2014. https://repositorio.ufpe.br/handle/123456789/19711.
Повний текст джерелаMade available in DSpace on 2017-07-17T15:08:06Z (GMT). No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) CUSTO UTILIDADE DA INSULINA GLARGINA E NPH REV 4.pdf: 871032 bytes, checksum: 61243dd09cce2d9260cb9239a873d2ca (MD5) Previous issue date: 2014-10-31
INTRODUÇÃO: O Diabetes Mellitus é um transtorno metabólico, caracterizado por hiperglicemia. É considerada condição sensível à Atenção Primária, tendo impacto por reduzir ou retardar as complicações da doença. A reposição de insulina para o diabete mellitus tipo 2 é indicada quando somente mudanças no estilo de vida associados a hipoglicemiante oral forem insuficientes para obter controle glicêmico. OBJETIVOS: Determinar o custo-utilidade da insulina glargina e insulina NPH para o tratamento de pacientes com diabetes mellitus tipo 2 atendidos no Sistema Único de Saúde do Município de Recife – PE. MÉTODOS: Foi realizada comparação da categoria custos médicos diretos de duas intervenções terapêuticas indicadas para o tratamento do diabete mellitus tipo 2. A avaliação de custo-utilidade foi realizada a partir da perspectiva do Sistema Único de Saúde. Foi considerado um horizonte analítico de 10 anos. Os dados coletados foram de fontes secundárias, de sistema de informação em saúde, dados dos relatórios emitidos nos sistemas de informatização das Farmácias do Recife e da Farmácia do Estado de Pernambuco e fontes da literatura. Para a análise de decisão, foram consideradas as hipoglicemias noturnas e não noturnas graves e não graves. RESULTADOS: O indivíduo médio, representante de Pernambuco, apresenta 8,7 anos de diagnóstico do DM2, recebem aproximadamente 14,4 frascos de insulina NPH ou Glargina ao ano, dados estes, utilizados na probabilidade de transição. Para o cenário das complicações agudas, o custo do usuário foi calculado para 2013: sem complicação em uso da insulina NPH foi de R$ 1.237,95 e para insulina Glargina R$ 4.935,42. Foi considerado 12 episódios de hipoglicemia noturna grave ao ano. A redução de risco de hipoglicemia para pacientes em uso da insulina Glargina é de 50,9% apresentando cinco episódios ao ano. A razão de custo incremental (RCEI) do presente estudo, indica um valor agregado adicionado de R$ 12.987,4892 por AVAQ ganho a cada ano de tratamento com a insulina glargina em relação a NPH. CONCLUSÕES: Houve redução de episódio de hipoglicemia noturna grave da insulina glargina comparado com a insulina NPH. Os dados apresentados não permite afirmar qual da intervenção é mais efetiva, apenas mostra que a insulina glargina tem um maior custo-utilidade e um custo médico direto maior. Os custos incrementais e os benefícios alcançados em anos de vidas ganhos produziu uma Razão de R$ 12.987,4892 ao ano para a insulina glargina. Diante das incertezas acerca da efetividade das insulinas analisadas, faz-se necessário a realização de estudos aprofundados entre estas intervenções terapêuticas.
INTRODUCTION: Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. It is considered sensitive to Primary Health Care, considering its impacting to reduce or delay complications of the disease. Replacement of insulin for diabetes mellitus type 2 is indicated only when changes in lifestyle associated with oral hypoglycemic agents are insufficient to obtain glycemic control. OBJECTIVES: To determine the cost-utility of insulin glargine and NPH insulin for the treatment of patients with type 2 diabetes mellitus treated at the Unified Health System of the Municipality of Recife - Pernambuco. METHODS: We compared the direct medical costs of category two therapeutic interventions indicated for the treatment of diabetes mellitus type 2 was performed Assessment of cost-utility analysis was performed from the perspective of the Health System was considered an analytic horizon of 10 years.. The data were collected from secondary sources of health information system data reports issued in the computerization of Pharmacies and Pharmacy Recife Pernambuco State and literature sources systems. For decision analysis, were considered nocturnal hypoglycemia and nocturnal not serious and not serious. RESULTS AND DISCUSSION: The average individual, representative of Pernambuco, has 8.7 years of diagnosis of T2DM, receive approximately 14.4 vials of NPH or glargine per year, these data are used in the transition probability. For the setting of acute complications, the user cost was calculated for 2013: Uncomplicated in use NPH insulin was R$ 1,237.95 and R$ 4,935.42 insulin glargine. Was considered 12 episodes of severe nocturnal hypoglycemia per year. The reduced risk of hypoglycemia for patients on insulin glargine is 50.9% with five episodes per year. The ratio of incremental cost (ICER) of this study, indicates a value added of R$ 12,987.4892 per QALY gained every year of treatment with insulin glargine compared to NPH. CONCLUSION: There was a reduction of severe nocturnal hypoglycemia episode of insulin glargine compared with NPH insulin. The data presented allows not say which intervention is most effective, just shows that insulin glargine has a higher utility cost and a direct medical cost higher. Incremental costs and benefits achieved gains in years of life produced a ratio of R$ 12.987,4892 year to insulin glargine. Given the uncertainties about the effectiveness of insulin analyzed, it is necessary to conduct in-depth studies of these therapeutic interventions.
Dash, Satya. "Analysis of TBC1D4 genetic variants in patients with severe insulin resistance." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609172.
Повний текст джерелаOng, Kenneth Kian Leong. "Longitudinal analysis of the insulin gene minisatellite and insulin-like growth factors in human size at birth and early childhood growth." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619807.
Повний текст джерелаHernández, Adrian V., Vinay Pasupuleti, Zapata Vicente A. Benites, Priyaleela Thota, Abhishek Deshpande, and Lopez Faustino R. Perez. "Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis." Elsevier B.V, 2015. http://hdl.handle.net/10757/582697.
Повний текст джерелаHernandez, Adrian V., Vinay Pasupuleti, Vicente A. Benítes-Zapata, Priyaleela Thota, Abhishek Deshpande, and Lopez Faustino R. Perez. "Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis." Elsevier B.V, 2015. http://hdl.handle.net/10757/621216.
Повний текст джерелаRevisión por pares
Rubino, Maria. "Second trimester amniotic fluid insulin and glucose as predictors of macrosomia." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111582.
Повний текст джерелаLim, Kang-Il. "Insulin stimulated glucose uptake : the influence of hyperglycemia and protein kinase C inhibition." Virtual Press, 2002. http://liblink.bsu.edu/uhtbin/catkey/1236582.
Повний текст джерелаSchool of Physical Education
Camargo, Rafael Ludemann 1986. "Taurine supplementation in malnourished obese animals = analysis of the molecular mechanisms of the hypothalamic action of insulin and leptin and the repercusion upon energy metabolism = Suplementação de taurina em animais desnutridos obesos: análise dos mecanismos moleculares da ação hipotalâmica da insulina e leptina e repercussões no metabolismo energético." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314187.
Повний текст джерелаTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-25T14:25:42Z (GMT). No. of bitstreams: 1 Camargo_RafaelLudemann_D.pdf: 2850934 bytes, checksum: 04c9b4c4f0335f5418dbc5e0a6df5dea (MD5) Previous issue date: 2014
Resumo: O balanço energético é preponderantemente controlado por regiões hipotalâmicas que recebem informações aferentes oriundas da periferia. Os estoques de energia sensibilizam neurônios hipotalâmicos que controlam a ingestão e o gasto energético, regulando assim o peso corporal. A desnutrição e a obesidade estão relacionadas ao desequilíbrio da homeostase energética. Evidências mostram que o consumo de dieta hiperlipídica (DHL) ativa vias inflamatórias no hipotálamo que prejudicam ações da insulina no controle do balanço energético. Além disso, o consumo de DHL também prejudica ações anorexigênicas da leptina e sua sinalização hipotalâmica. Neste estudo, avaliamos o consumo e o gasto energético, bem como os mecanismos moleculares e genéticos envolvidos na sinalização da insulina e leptina hipotalâmica e seu controle sobre o padrão alimentar e metabólico de camundongos submetidos à restrição protéica e alimentados com DHL. Além disso, verificamos os possíveis efeitos benéficos da suplementação com o aminoácido taurina (Tau), associado a DHL, nos perfis moleculares e fisiológicos analisados neste estudo. Para isso, logo após o desmame, camundongos C57BL/6 foram alimentados com dieta controle (14% de proteína ¿ grupo C) ou hipoprotéica (6% de proteína ¿ grupo R), sendo suplementados ou não com 5% de Tau na água de beber (grupos CT e RT). Após 6 semanas, os grupos receberam ou não DHL durante 8 semanas (grupos CHT e RHT). Animais submetidos a restrição protéica apresentaram maior sensibilidade periférica a insulina, apesar da deficiência na sensibilidade hipotalâmica deste hormônio. Os grupos em estudo apresentaram modificações na expressão de genes hipotalâmicos relacionados a defesa celular, apoptose, stress do retículo endoplasmático e controle da ingestão alimentar. Houve maior expressão gênica dos neuropeptidios orexigênicos em camundongos submetidos a restrição protéica, caracterizando hiperfagia, apesar de uma ingestão calórica normal. Camundongos DHL apresentaram hipofagia e menor expressão gênica dos neuropeptídeos anorexigênicos. Entretanto, o consumo de DHL em animais controles e desnutrido, propiciou maior ingestão calórica, culminando com aumento de peso e dos estoques de gordura. Camundongos DHL apresentaram também comprometimento da ação anorexigênica da leptina. Além disso, houve aumento da expressão protéica da uncoupling protein 1 (UCP1) no tecido adiposo marrom (TAM), assim como do quociente respiratório (QR) durante o período escuro em camundongos submetidos a restrição protéica. Por outro lado, houve diminuição da expressão protéica da UCP1 no TAM e do QR em camundongos DHL. Houve diminuição no gasto energético (GE) de animais DHL apenas na fase clara. Em conclusão, camundongos submetidos a restrição protéica apresentaram comprometimento da ação da insulina no hipotálamo, aumento da expessão dos neuropeptídios orexigênicos e do consumo alimentar. Além disso, o consumo de DHL promoveu obesidade, hipercolesterolamia, intolerância a glicose, aumento da ingestão calórica e prejuízo na ação da insulina e leptina. Entretanto, a suplementação com Tau preveniu alterações na homeostase glicêmica, no consumo calórico, na ação hipotalâmica da insulina e leptina em camundongos DHL. Por outro lado, a melhora desses padrões metabólicos mostrou-se menos eficaz em camundongos submetidos a restrição protéica. Por fim, o comprometimento do gasto energético e da atividade locomotora em animais obesos não foram restabelecidos com a suplementação de Tau
Abstract: The energy balance is mainly controlled by hypothalamic regions that receive afferent information arising from the periphery. Energy stocks sensitize hypothalamic neurons that control food intake and energy expenditure, thus regulating body weight. Malnutrition and obesity are related to an imbalance of energy homeostasis. Evidence shows that consumption of high-fat diet (HFD) activates inflammatory pathways in the hypothalamus that affect the actions of insulin in the control of energy balance. Moreover, consumption of HFD also impairs anorexigenic actions of leptin and its hypothalamic signaling. In this study, we evaluated the consumption and energy expenditure, as well as the molecular and genetic mechanisms involved in insulin and leptin signaling in the hypothalamus and its control over the food and metabolic pattern of malnourished mice fed with HFD. Furthermore, we verified the possible beneficial effects of supplementation with the amino acid taurine (Tau) associated with HFD in molecular and physiological profiles analyzed in this study. Thereunto, soon after weaning, C57BL/6 mice were fed with control diet (14% protein ¿ group C) or low protein diet (6% protein ¿ group R) and supplemented or not with 5% of Tau in the drinking water (CT and RT groups). After 6 weeks, the groups received or not HFD for 8 weeks (CHT and RHT groups). Animals subjected to protein restriction had a higher peripheral insulin sensitivity, despite the deficiency of this hormone in hypothalamic sensitivity. The study groups showed changes in hypothalamic expression of genes related to cellular defense, apoptosis, endoplasmic reticulum stress and the control of food intake. There was a higher gene expression of orexigenic neuropeptides in mice subjected to protein restriction, featuring a hyperphagia despite a normal caloric intake. HFD mice showed hypophagia and reduced gene expression of anorexigenic neuropeptides. However, consumption of HFD in controls and malnourished animals provided higher caloric intake, leading to weight gain and fat stores. HFD mice also exhibited an impaired anorexigenic effect of leptin. In addition, there was an increase in protein expression of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) and respiratory quotient (RQ) during the dark period in mice subjected to protein malnutrition. On the other hand, there was a decrease in the protein expression of UCP1 in the BAT and RQ in HFD fed mice. There was a decrease in energy expenditure (EE) in HFD animals only during the light phase. In conclusion, mice subjected to protein restriction showed an impairment of insulin action in the hypothalamus and an increase of the orexigenics neuropeptides genes expressions as well as food intake. Moreover, consumption of HFD promoted obesity, hipercolesterolamia, glucose intolerance, increased caloric intake and impaired of hypothalamic action of insulin and leptin. However, Tau supplementation prevented alterations in glucose homeostasis, caloric intake and hypothalamic action of insulin and leptin signaling in HFD mice. Moreover, the improvement in these metabolic patterns was less effective in mice subjected to protein restriction. Finally, the impairment of energy expenditure in obese animals and spontaneous locomotor activity were not restored by supplementation of Tau
Doutorado
Fisiologia
Doutor em Biologia Funcional e Molecular
Melvin, Derek Robert. "Analysis of trafficking motifs in the insulin-responsive glucose transporter isoform, GLUT4." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264144.
Повний текст джерелаLee, Adrian. "Analysis of insulin-like growth factor-II in human breast cancer cells." Thesis, University of Surrey, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335638.
Повний текст джерелаBellows, William D. (William Devereaux). "Analysis of randomly occurring high injection forces in an insulin delivery device." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/92226.
Повний текст джерелаThesis: M.B.A., Massachusetts Institute of Technology, Sloan School of Management, 2014. In conjunction with the Leaders for Global Operations Program at MIT.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 57-58).
During manufacturing scale-up of a new product, new failure modes often surface which require corrective action. However, as production numbers of an insulin injection device pass 200 million per year, testing continues to find sub-assemblies with too-high injection forces, seemingly at random. Up until now, no corrective action has been effective in preventing these problems. These non-conforming sub-assemblies cause batches to be rejected, reducing the production yield at Sanofi's Site Frankfurt Devices (SFD) production facility. This thesis describes the current state of rejected batch problem solving and explores the application of new methods to better understand the root problems and improve the process. Frequency spectra analysis of testing data using the Fast Fourier Transform (FFT), combined with device physics, identified the key interaction points within the sub-assemblies. This model of part interactions has been verified through testing of purpose-built defective pieces and examination of defective parts. The verified model was then used to identify which components within sub-assemblies cause non-conformances. The root causes of several failure codes were determined, and results were further confirmed by rebuilding and retesting subassemblies with the identified problem components. These results confirm the usefulness of this novel application of frequency analysis to a new field of industrial troubleshooting. Various improvement and control methods are explored and next steps recommended for Sanofi to further improve quality control processes and thereby the production yield. The opinions expressed herein are solely those of the author and do not necessarily reflect those of Sanofi S.A.
by William D. Bellows.
S.M.
M.B.A.
Olinski, Robert Piotr. "Evolutionary Analysis of the Insulin-Relaxin Gene Family from the Perspective of Gene and Genome Duplication Events." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7892.
Повний текст джерелаPatel, Dhaval Subhas. "Analysis of the daf-2 insulin/igf-1 receptor gene in Caenorhabditis elegans." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445066/.
Повний текст джерелаTang, Lei. "The determination and structural analysis of site-directed dihydrofolate reductase and insulin mutants." Thesis, Open University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338337.
Повний текст джерелаMalvezzi, Maria Aparecida Pereira Nunes. "Efeito dose-resposta do fluoreto em parâmetros relacionados à resistência à insulina e na expressão de proteínas hepáticas e musculares em camundongos NOD." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/25/25149/tde-24012019-090227/.
Повний текст джерелаWhile some studies report that chronic administration of fluoride (F) causes insulin resistance, a recent study in our group found that in animals with diabetes previously induced by streptozotocin diabetes, chronic low-dose F administration increases insulin sensitivity by interfering with metabolic pathways in muscle and liver. However, streptozotocin-induced diabetes causes different metabolic changes from type 1 diabetes. Thus, it would be interesting to see whether increased insulin sensitivity induced by low doses of F would also occur using a diabetes model that better mimics type1 diabetes (NOD mice - non-obese diabetic). Based on the foregoing, the present study investigated in NOD mice chronically exposed to doses of F in drinking water that simulate the ingestion of F by artificial or naturally fluoridated water, if there are changes related to insulin resistance as well as in the expression of liver and muscle proteins. Twenty-four NOD mice, obtained immediately after weaning, were divided into three groups, according to the concentration of F present in the drinking water (0, 10 or 50 ppm), which was administered by a period of 21 days. After the experimental period, the animals were euthanized and the blood was collected for analysis of F (ionspecific electrode), glucose (glucose oxidase method) and insulin (ELISA), as well as the liver and gastrocnemius muscle, for quantitative proteomic analysis (Protein Linx Global Service software). Data were analyzed by ANOVA and Tukey\'s test, or Kruskal- Wallis and Dunn\'s test (p <0.05). Only the group treated with 50 ppm F had plasma F concentration significantly higher than the control group. Animals treated with 10 ppm F had significantly lower glycemia than the control group, but there was no significant difference between the groups in relation to insulinemia. The % of pancreatic -cell function was significantly higher in the group treated with 10 ppm F compared to the others. Proteomic analysis revealed changes in the proteomic profile of both muscle and hepatic tissue. In the muscle tissue, the group of 10 ppm presented, in relation to the control, increased expression of proteins involved in energy metabolism. The group of 50 ppm F, in relation to 7control, presented increased expression of proteins related to muscle contraction, differentiation of brown adipose tissue and apoptosis. For hepatic tissue, increased expression was also observed in the group of 10 ppm F in relation to the control of proteins involved in energetic metabolism and protein synthesis, with emphasis also on the increase of Glutahione S transferase isoforms as well as Heat shock-related 70 kDa protein 2. In the group treated with 50 ppm F proteins related to ROS metabolism and energetic metabolism were altered. Increased expression of antioxidant proteins by treatment with low F concentration may help explain protection against the development of diabetes, which should be demonstrated in future mechanistic studies.
McGarry, Robert Gerard. "Modelling insulin/glucose dynamics and application to the analysis of oral glucose tolerance tests." Thesis, Queen's University Belfast, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335562.
Повний текст джерелаMillar, Caroline Ann. "Analysis of the subcellular distribution and trafficking of the insulin-responsive glucose transporter, GLUT4." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284933.
Повний текст джерелаWatson, Nicol D. "A biochemical and proteomic analysis of glucosamine-treated, insulin-resistant cultured human muscle cells." Thesis, University of Newcastle Upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432496.
Повний текст джерелаKiefer, Julie Christine. "Analysis of myogenic regulatory factors and insulin-like growth factors in early somite myogenesis /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/9227.
Повний текст джерелаGriffiths, Matthew Rhodri. "Analysis of signal transduction pathways involved in the activation of gene transcription by the insulin receptor." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265456.
Повний текст джерелаSit, Kei Chun. "Investigation of the binding interactions between insulin and its receptor." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/87276/1/Kei_Sit_Thesis.pdf.
Повний текст джерелаMcElwee, Joshua J. "A comparative analysis of transcriptional alterations in long-lived insulin/IGF-1-like signaling mutants in Caenorhabditis elegans and Drosophila melanogaster /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/4982.
Повний текст джерелаStankūnaitė, Eglė. "Pharmacoepidemiological study and costs analysis of oral antidiabetic drugs and insulins in Lithuania on 2006-2009 year." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100621_092504-76708.
Повний текст джерелаTikslai: Įvertinti geriamųjų antidiabetinių vaistų ir insulinų suvartojimo tendencijas Lietuvoje 2006–2009 m. ir atlikti farmakoekonominę analizę kaštų mažinimo ir referentinės kainos metodu siekiant racionaliai panaudoti sveikatos apsaugos lėšas cukriniam diabetui gydyti. Medžiaga ir metodai: Duomenys apie antidiabetinių vaistų farmakokinetines ir farmakodinamines savybes buvo surinkti iš MEDLINE elektroninių duomenų šaltinių. Duomenys apie antidiabetinių vaistų pardavimą Lietuvoje 2006–2009 metais gauti iš UAB SoftDent duomenų bazės. Vaistai klasifikuoti pagal anatominę terapinę cheminę (ATC) klasifikaciją. Vaistų suvartojimas buvo vertinamas pagal apibrėžtos dienos dozės (DDD – angl. defined daily dose) metodiką, o duomenys apskaičiuoti pagal DDD skaičių, tenkantį 1000 gyventojų per vieną dieną.Vaistų kainų skaičiavimai atlikti remiantis mažmenine kaina iš „Kompensuojamų vaistinių preparatų kainynų“. Antidiabetinių vaistų farmakoekonominei analizei atlikti taikytas kaštų mažinimo bei referentinės kainos nustatymo metodas. Rezultatai: Bendras antidiabetinių vaistų suvartojimas padidėjo 33,33% nuo 21,54 DDD/TID 2006 metais iki 28,72 DDD/TID 2009 metais. Insulinų suvartojimas padidėjo 30% ir siekė 9,43 DDDD/TID 2009 metais, o geriamųjų antidiabetinių vaistų suvartojimas pakilo 35% iki 19,29 DDD/TID 2009 metais. Palyginus su kitų Europos šalių duomenimis, Lietuvoje antidiabetinių vaistų suvartojimas buvo du-tris kartus mažesnis, nepaisant to, jog sergamumas cukriniu diabetu... [toliau žr. visą tekstą]
Zhou, Rui. "Functional analysis of insulin-like growth factor binding protein -4 and -6 in transgenic mice." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-12058.
Повний текст джерелаRichards, Hannah B. "Functional analysis of type 2 diabetes associated transcripts." Thesis, University of Oxford, 2014. https://ora.ox.ac.uk/objects/uuid:a1da01e0-5e60-4d4a-a621-6f1cae17a1d8.
Повний текст джерелаMabugana, Matamela Charles. "Analysis of the role of nuclear factor-kappa B in insulin resistance caused by antiretroviral drugs." Diss., University of Pretoria, 2020. http://hdl.handle.net/2263/79321.
Повний текст джерелаDissertation (MSc (Chemical Pathology))--University of Pretoria, 2020.
National Research Foundation (NRF)
Chemical Pathology
MSc (Chemical Pathology)
Restricted
Landis, Justine M. "Mechanistic Analysis of Differential Signal Transduction Mediated by the Insulin Receptor Substrate Proteins IRS-1 and IRS-2: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/735.
Повний текст джерелаLandis, Justine M. "Mechanistic Analysis of Differential Signal Transduction Mediated by the Insulin Receptor Substrate Proteins IRS-1 and IRS-2: A Dissertation." eScholarship@UMMS, 2008. http://escholarship.umassmed.edu/gsbs_diss/735.
Повний текст джерелаBaroni, Marco Giorgio. "Genetic analysis of non-insulin dependent diabetes mellitus (NIDDM) using DNA markers at candidate gene loci." Thesis, Queen Mary, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294972.
Повний текст джерелаMikawa, Satoshi. "STRUCTURAL ANALYSIS AND EXPRESSION OF THE GENES FOR GOAT GROWTH HORMONE AND INSULIN-LIKE GROWTH FACTOR-I." Kyoto University, 1995. http://hdl.handle.net/2433/160854.
Повний текст джерелаKyoto University (京都大学)
0048
新制・課程博士
博士(農学)
甲第6065号
農博第835号
新制||農||696(附属図書館)
学位論文||H7||N2788(農学部図書室)
UT51-95-D384
京都大学大学院農学研究科農芸化学専攻
(主査)教授 駒野 徹, 教授 佐々木 隆造, 教授 内海 恭三
学位規則第4条第1項該当
Renner, Benjamin Johannes [Verfasser]. "Detailed analysis of modulating effects of Clusterin in insulin and IGF-1 signal transduction / Benjamin Johannes Renner." Mainz : Universitätsbibliothek Mainz, 2017. http://d-nb.info/1148989269/34.
Повний текст джерелаSpaeth, Brianne, and Barbara Fontana. "A Cost-Effectiveness Analysis Comparing Glargine Versus Rosiglitazone or Pioglitazone for Patients Failing Metformin Plus a Sulfonylurea." The University of Arizona, 2008. http://hdl.handle.net/10150/624269.
Повний текст джерелаObjectives: To determine the cost-effectiveness of adding a thiazolidinedione (TZD) versus insulin glargine (glargine) as a triple regimen for treatment of Type 2 diabetes mellitus for patients not controlled with metformin and a sulfonylurea. Methods: A decision analytic model was developed to compare the clinical outcomes and costs of triple therapy with either a TZD or glargine. Published literature was used to determine treatment efficacy and the frequency of clinically important adverse effects. Cost data were obtained from the 2007 Physician Fee Reference and North Carolina Industrial Commission website. The decision tree was built using TreeAge software. Clinical outcome measures included HgA1c (A1C) control, hypoglycemia frequency, and the development of edema associated with the use of these medications. A Monte Carlo probabilistic sensitivity analysis was conducted to determine the mean and 95% CIs for both treatment efficacy and costs. Results: There was no statistically significant difference in the efficacy of adding either a TZD or glargine in achieving a goal A1C ≤ 7%. However, glargine triple therapy was estimated to be significantly less costly than TZD triple therapy ($3,161/yr; 95% CI $3,116 to $3,356 versus $3,769/yr; 95% CI $3,667 to $3,902, respectively). Conclusions: Most patients requiring triple therapy for the management of T2DM should receive glargine rather than a TZD due to the significantly lower cost producing similar clinical efficacy.
Evaneshko, Veronica. "Exploratory data analysis of type II diabetes among Navajo Indians." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276762.
Повний текст джерелаGautam, Dinesh Chandra. "Analysis of insulin receptor function in the central nervous system by conditional inactivation of its gene in mice." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=96492353X.
Повний текст джерелаPirog, Antoine. "An embedded system for the multiparametric analysis of biological signals : application to the pancreatic biosensor of insulin demand." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0836/document.
Повний текст джерелаExtracellular recording of electrical activity is a widespread technique in neurosciences, but only recently has it been applied to pancreatic islets and beta cells. The ease of use of Microelectrode Arrays (MEAs) has opened new perspectives for the electrophysiology of pancreatic cells, including screening methods for clinics and biosensor approaches for the artificial pancreas. This thesis is a contribution to the design and characterization of a hybrid biosensor composed of pancreatic cells cultured on an MEA and dedicated processing electronics. This device is the product of multi-disciplinary projects conducted at IMS (Bioelectronics group), partnered with CBMN (Cell biology and Biosensors team), both at the University of Bordeaux. Projects also involved the endocrinology service of university hospitals in Bordeaux, Montpellier, Grenoble, and Geneva.The covered projects include:- ISLET-CHIP (French ANR 2013-PRTS-0017), investigating a method of evaluating the quality of a preparation prior to its transplantation in type-I diabetic patients.- BIODIA (EU FEDER), characterizing islet electrical response to glucose, hormone, and drug stimuli for screening, cell differentiation, and closed-loop approaches.- DIAGLYC (French regional grant 2017 1R30 226), investigating the use of the hybrid biosensor as an artificial pancreas front-end sensor.The thesis tackles the biosensor in both its electronic and biological aspects, its integration in applicative experimental setups, and experimental results. It also addresses the modeling of a closed regulation loop for type-I diabetic patients.First, the electronic processing platform is described. It is a custom board performing multichannel acquisition and digital signal processing. It is built around an FPGA (Field Programmable Gate Array) that makes its processing architecture versatile and evolutive. It is capable of measuring, displaying and storing multichannel data. Computation was optimized for low-processing latencies compatible with closed-loop configurations. Both its processing algorithms and architecture are detailed.Then, experimental results using this system and its algorithms are shown to illustrate islet response to glucose, drug, and hormone stimuli. Islet activity is quantified by analyzing Action Potentials (APs), and more importantly Slow Potentials (SPs), a novel electrical signature exclusively measured on pancreatic islets. These measurements in both steady state and dynamic regime help characterize the biosensor response, but also shed light on the endogenous algorithms of islets of Langerhans.Finally, approaches for integrating the biosensor in an artificial pancreas are investigated. The measured glucose and hormone responses are modeled and simulated in a full-body glucose-insulin system. This concept is novel in that the sensor in charge of measuring insulin demand in the body is not only sensitive to glucose, but also to blood hormones
Martí, Aluja Idoia. "Analysis of polymerisation / aggregation processes by nir chemical imaging and ftir spectroscopy." Doctoral thesis, Universitat Rovira i Virgili, 2013. http://hdl.handle.net/10803/125668.
Повний текст джерелаThe overall objective of this thesis is to develop analytical methods based on infrared spectroscopy and chemometric techniques to analyse two different processes that involve a state change from a liquid to a solid. The first studied process is a polymerisation process and it was followed by near-infrared chemical imaging (NIR-CI). The chemometric treatment of the images acquired allowed evidencing a tautomer’s equilibrium of one of the reagents. The second studied process was insulin aggregation. Aggregation process was monitored infrared spectroscopy (IR), and different methods were established which allowed on the one hand the assessment of the effect of antiretroviral drugs on the process; and on the other hand, the influence of biochemical variables on the process.
Morrice, Nicola. "Endocrine and genomic analysis of Fenretinide-mediated retinoic acid receptor signalling in models of obesity and type-2 diabetes." Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=232274.
Повний текст джерелаInteeworn, Natalie. "The Effect of Hypothyroidism on Glucose Tolerance in Dogs." Thesis, Virginia Tech, 2008. http://hdl.handle.net/10919/32030.
Повний текст джерелаMaster of Science
Sah, Pri Azurahisham. "Analysis, development and management of glucose-insulin regulatory system for out of hospital cardiac arrest (ohca) patients, treated with hypothermia." Thesis, University of Canterbury. Mechanical Engineering, 2015. http://hdl.handle.net/10092/10498.
Повний текст джерела