Дисертації з теми "Innatene"
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Morra, Erica, and Lisa Zenker. "Chapter 1: In Search of Innate Leadership : Discovering, Evaluating and Understanding Innateness." Thesis, Linnéuniversitetet, Institutionen för organisation och entreprenörskap (OE), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-34622.
Повний текст джерелаPelissier, Kiara. "INNATE." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/1016.
Повний текст джерелаUsui, Naoki. "Innateness and the mind." Thesis, University of Sheffield, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.617026.
Повний текст джерелаAriew, Andre 1968. "Innateness: A developmental account." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/289478.
Повний текст джерелаBachtel, April. "Innate Materiality." Kent State University Honors College / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1304282952.
Повний текст джерелаMerritt, Michele. "Minimally innate ideas." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0001993.
Повний текст джерелаHazeldine, Jon. "Mechanisms underlying innate immunesenescence." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/3965/.
Повний текст джерелаDaley, Kenneth. "Concepts as constructions: Structure, content, and innateness." Connect to online resource, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3288722.
Повний текст джерелаMukhopadhyay, Subhankar. "Innate immune activation of macrophages." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414236.
Повний текст джерелаVakakis, Emmanouil. "Innate immune responses to Picornaviridae." Thesis, University of Sussex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516152.
Повний текст джерелаCrowley, Thomas. "Innate immune memory in fibroblasts." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8060/.
Повний текст джерелаAhrens, S. "Extracellular actin in innate immunity." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1433762/.
Повний текст джерелаKästele, Verena. "Intestinal migratory innate lymphoid cells." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/30723/.
Повний текст джерелаScoville, Steven. "Human Innate Lymphoid Cell Development." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1459952541.
Повний текст джерелаRamanathan, Balaji. "Innate immunity : receptors and effectors /." Search for this dissertation online, 2004. http://wwwlib.umi.com/cr/ksu/main.
Повний текст джерелаTRIGGIANESE, PAOLA. "Innate lymphoid cells: a potential innate functional equivalent of adaptive cells in infertility and inflammatory arthropathies." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2015. http://hdl.handle.net/2108/203137.
Повний текст джерелаKirby, Simon. "Function, selection and innateness : the emergence of language universals." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/21340.
Повний текст джерелаMcAuley, Julie Louise. "MUC1 in innate and adaptive immunity /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19061.pdf.
Повний текст джерелаGoritschnig, Sandra. "Protein modification in plant innate immunity." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/30887.
Повний текст джерелаScience, Faculty of
Botany, Department of
Graduate
Linde, Annika. "Comparative studies on cardiac innate immunity." Diss., Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/946.
Повний текст джерелаHaghayeghi, Amirhossein. "Pellino function in «Drosophila» innate immunity." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86930.
Повний текст джерелаLa transduction de signal initiée par Toll active l'immunité innée. Cet événement constitue la première ligne de défense contre des agents pathogènes chez les vertébrés et les invertébrés. Dans la Drosophile, la transduction de signal initiée par Toll protège contre les bactéries Gram-positives et les champignons en induisant la production de peptides antimicrobiens tels que Drosomycin. Pellino est une protéine hautement conservée qui interagit biochimiquement avec Pelle/IRAK, une kinase essentielle activée par Toll. Ici, nous reportons que Pellino 7T2, un mutant chimiquement induit, n'affecte pas la fonction de Toll durant l'établissement de la polarité dorsoventral dans les embryons précoces. Cependant, Pellino affecte l'induction de Drosomycin suite à une infection avec les bacteries Gram-positive Micrococcus luteus. Dans cette étude, nous reportons un nouveau rôle à Pellino, notamment, celui d'un élément de la voie de signal initiée par Toll qui impacte l'immunité innée.
Truman, William Matthew Donald. "Signalling pathways underylying plant innate immunity." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429264.
Повний текст джерелаZilbauer, Matthias. "Innate immune defence to Campylobacter jejuni." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445170/.
Повний текст джерелаYim, Chi-ho Howard, and 嚴志濠. "Mechanisms of mycobacteria-induced innate responses." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45200981.
Повний текст джерелаLunnon, Katie Sarah. "Innate inflammation's contribtion to chronic neurodegeneration." Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443033.
Повний текст джерелаMatsumiya, Magali Maya Laurence. "Innate immune responses to tuberculosis vaccines." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:bcec5004-fd34-4d36-b088-c0b7e31a87f8.
Повний текст джерелаBoughan, P. K. "Innate immune defence to Helicobacter pylori." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444551/.
Повний текст джерелаKar, Satwik. "Innate immune response to respiratory viruses." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/73374/.
Повний текст джерелаElcombe, Suzanne E. "The innate response to fungal infection." Thesis, University of Dundee, 2013. https://discovery.dundee.ac.uk/en/studentTheses/bd524bb3-6273-4ea3-9faa-7ef7092755d3.
Повний текст джерелаMcGlasson, Sarah Louise. "Regulation of the innate immune system." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/17911.
Повний текст джерелаKiritsy, Michael C. "Functional Genomics of Mammalian Innate Immunity." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1102.
Повний текст джерелаBryner, Charles Heather Marie. "Factors Regulating Insect Innate Immune Responses." Miami University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=miami149088600671424.
Повний текст джерелаDayel, Iman Bin. "Probiotics, innate immunity & ageing (PRIMAGE)." Thesis, University of Reading, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.658873.
Повний текст джерелаVajhi, Jafari N. "Defining innate immunity to Clostridium difficile." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1347959/.
Повний текст джерелаCamargo, Ramírez Rosany del Carmen. "Function of microRNAs in plant innate immunity." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/405716.
Повний текст джерелаThis thesis comprises the study of miRNAs in innate immunity in plants. The work has been developed in rice (Chapter I and Chapter II) and in Arabidopsis (Chapter III), model systems used in studies of functional genomics in monocotyledonous and dicotyledonous species, respectively. Chapter I describes the functional identification and characterization of new rice miRNAs in their interaction with the fungus Magnaporthe oryzae. This fungus is responsible for blast disease, one of the most devastating diseases for rice cultivation worldwide. From the information generated by high-throughput sequencing of small rice RNA libraries, candidate sequences to represent novel rice miRNAs were selected. In this work 5 of these candidates have been studied (miR-64, miR-75, miR-96, miR-98 and miR-203). Obtaining transgenic rice lines has demonstrated that the overexpression of MIR-64 and MIR-75 confers resistance to M. oryzae, therefore these miRNAs function as positive regulators in the rice immune response. Moreover, overexpression of MIR-96, MIR-98 or MIR-203 increase susceptibility to M. oryzae in rice plants (negative regulators of immune response). Analysis of rice mutants affected in the miRNA biogenesis (dcl1, dcl3 and dcl4 mutants) indicate that the mature miRNA production of miR-64, miR-75 or miR-96 depends on DCL3 and/or DCL4, which supports the idea that they are novel rice miRNAs. Furthermore, by gene editing using CRISPR/Cas9, it has been found that a 22 nucleotides deletion in miR-75 precursor results in a susceptibility phenotype under M. oryzae infection (Chapter II), in agreement with a resistance phenotype that was observed in overexpressor plants for this miRNA. In chapter III, the miR858 function in Arabidopsis thaliana innate immunity to infection by pathogenic fungi was studied. This miRNA represses the expression of MYB transcription factors, which act as activators of the expression of genes involved in flavonoids biosynthesis. Plants are resistant to infection by pathogenic fungi (Plectosphaerella cucumerina, Fusarium oxysporum f. sp. Conglutinans and Colletotrichum higginsianum) when the activity of miR858 is blocked by the expression of target mimicry (MIM858 plants), while the overexpression of this miRNA confers greater susceptibility to infection. Additionally, interference with miR858 activity and consequent increase of MYB gene expression in MIM858 plants significantly affects phenylpropanoids metabolism, favoring the synthesis and accumulation of flavonoids, and disfavoring the synthesis of lignin precursors. The antifungal activity that was observed for Kaempferol, naringenin (flavonoids) and p-Coumaric acid, would explain the resistant phenotype by fungi infection which is observed in the MIM858 plants. Altogether, the results obtained in this work demonstrate that miRNAs are an important component in the resistance/susceptibility to infection by pathogenic fungi in Arabidopsis and rice plants. Greater knowledge of miRNA function in plant innate immunity and processes that are regulate by these riboregulators, can be useful in the design of new strategies for the control of diseases in plants.
Baldrich, Patricia. "Role of microRNAs in plant innate immunity." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/315463.
Повний текст джерелаSmall RNAs (sRNAs) are short non-coding RNAs that guide gene silencing in most eukaryotes. Plants have two main classes of sRNAs, microRNAs (miRNAs) and small interfering RNAs (siRNAs), which are distinguished by their mode of biogenesis and mechanisms of action. In this day and age, crop losses due to pathogens and pests are estimated from 50% to 80%, factors limiting crop production and causing important economical losses. There is then an imperative need to improve our knowledge in defense mechanisms and to develop novel strategies for crop protection. To improve the understanding in this field, we carried out studies in Arabidopsis and rice plants, the two model systems used for functional genomic studies in dicot and monocot plant species. In the first chapter, we analyzed alterations on the accumulation of smRNAs in response to elicitor treatment, including miRNAs, in Arabidopsis plants. Among the elicitor-regulated miRNAs was miR168 which regulates ARGONAUTE1, the core component of the RNA-induced silencing complex involved in miRNA functioning. In addition to known miRNAs, microarray analysis allowed the identification of an elicitor-inducible small RNA that was incorrectly annotated as a miRNA in the miRBase registry. We demonstrated that this smRNA, is a heterochromatic-siRNA (hc-siRNA) named as siRNA415. In the second chapter, we used deep sequencing of small RNA libraries for global identification of rice miRNAs that are regulated by fungal elicitors. We also describe 9 previously uncharacterized miRNAs. Combined small RNA and degradome analyses revealed regulatory networks enriched in elicitor-regulated miRNAs supported by the identification of their corresponding target genes. Specifically, we identified an important number of miRNA/target gene pairs involved in small RNA pathways, including miRNA, heterochromatic and trans-acting siRNA pathways. We present evidence for miRNA/target gene pairs implicated in hormone signaling and cross-talk among hormone pathways having great potential in regulating rice immunity. Furthermore, we describe miRNA-mediated regulation of Conserved-Peptide upstream Open Reading Frame (CPuORF)-containing genes in rice, which suggests the existence of a novel regulatory network that integrates miRNA and CPuORF functions in plants. The knowledge gained in this study will help in understanding the underlying regulatory mechanisms of miRNAs in rice immunity and develop appropriate strategies for rice protection. In the third chapter, we used a combination of bioinformatic tools and experimental analyses for the discovery of new polycistronic miRNAs in rice, revealing 23 loci with the ability to form the typical hairpin structure of miRNA precursors in which two or more mature miRNAs mapped along the same structure. Evidence is presented on the polycistronic nature of 7 miRNA precursors containing homologous or non-homologous miRNA species. We also demonstrated a pattern of conservation in the genome of rice (Oryza sativa) species that have an AA genome, but not in primitive rice species. Collectivelly, results obtained in this work support the notion that miRNAs might be considered as components of the plant response to pathogen infection, possible acting as regulatory nodes of different physiological processes during plant adaptation to infection conditions.
Taylor, Kristen Rea. "Activation of cutaneous innate defense by glycosaminoglycans." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3211370.
Повний текст джерелаTitle from first page of PDF file (viewed June 13, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 142-162).
Hyun, Jinhee. "RIP1 and FADD's Role in Innate Immunity." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_dissertations/519.
Повний текст джерелаParvatiyar, Kislay. "Ubiquitin Dependent Regulation of Innate Antiviral Signaling." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/651.
Повний текст джерелаCordeiro, Cristianne. "Eggshell Membrane Proteins provide Innate Immune Protection." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/33389.
Повний текст джерелаThakur, Nishant. "Integrated signaling networks in C.elegans innate immunity." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4034/document.
Повний текст джерелаC. elegans is infected by diverse pathogens, including bacteria, fungi and viruses. Upon fungal infection, C. elegans up-regulates the expression of many antimicrobial peptide (AMP) genes. The main aim of my thesis was to build an integrated gene regulatory network representing the induction of these AMP genes upon infection. To find the main/backbone components of the regulatory network, through a genome-wide RNAi screen (Zugasti et al. 2016), we identified 278 Nipi (for “no induction of antimicrobial peptides after infection”) clones that abrogate AMP induction. Using “CloneMapper” (Thakur et al. 2014), we identified 338 target genes for these clones. We showed that MAPK pathways are central to the induction of AMPs. We also characterized the transcriptional changes provoked by infection using RNA-sequencing and identified more than 300 genes that are dynamically up-regulated after infection, including 13 AMPs. We validated 48 (96%) of 50 arbitrary selected up-regulated genes using Fluidigm. To assign functions to genes identified in these high-throughput studies, we developed a functional enrichment tool for C.elegans community (MS in preparation). We used this tool to analyse the genome-wide RNAi screen targets and other pathogen-related datasets. We did functional enrichment analysis of ChIPseq targets of CEBP-1, TF linked to the regulation of the innate immune response (Kim et al., submitted). Finally, to understand better the interaction between host and pathogen, we sequenced, assembled, annotated and analysed the D. coniospora genome (Lebrigand et al. 2016). We identified various potential virulence factors in the fungal genome
Noursadeghi, Mahdad. "Studies of innate immunity to bacterial infection." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406424.
Повний текст джерелаPaveley, Ross A. "Imaging innate immune responses to schistosoma mansoni." Thesis, University of York, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516640.
Повний текст джерелаLee, Mark N. "Genomic Approaches to Dissect Innate Immune Pathways." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10692.
Повний текст джерелаSmith, Christopher. "Avian innate immune responses to 'Campylobacter' infection." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432743.
Повний текст джерелаBarakat, Farah Mukhlis. "Protective innate immune responses against Cryptosporidium parvum." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8733.
Повний текст джерелаMilioris, A. S. "Modulation of innate immunity by enteropathogen motifs." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1482091/.
Повний текст джерелаMazzon, M. "Pathogenesis of dengue : subversion of innate immunity." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/134036/.
Повний текст джерелаRigby, Rachel Elizabeth. "Ribonuclease H2, RNA:DNA hybrids and innate immunity." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/6509.
Повний текст джерелаDias, Antonio Gregorio. "Characterisation of the innate impune sensor MDA5." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:8593db28-b4d3-4880-8831-4ea7837937f6.
Повний текст джерела