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Статті в журналах з теми "Innate immune signalling"
Guillamot, Maria, and Iannis Aifantis. "Splicing the innate immune signalling in leukaemia." Nature Cell Biology 21, no. 5 (April 22, 2019): 536–37. http://dx.doi.org/10.1038/s41556-019-0323-4.
Повний текст джерелаYu, Xiaoyu, Liyuan Zhang, Jingxiang Shen, Yanfang Zhai, Qifei Jiang, Mengran Yi, Xiaobing Deng, et al. "The STING phase-separator suppresses innate immune signalling." Nature Cell Biology 23, no. 4 (April 2021): 330–40. http://dx.doi.org/10.1038/s41556-021-00659-0.
Повний текст джерелаWeidenbusch, Marc, Onkar P. Kulkarni, and Hans-Joachim Anders. "The innate immune system in human systemic lupus erythematosus." Clinical Science 131, no. 8 (March 28, 2017): 625–34. http://dx.doi.org/10.1042/cs20160415.
Повний текст джерелаHopcraft, Sharon E., and Blossom Damania. "Tumour viruses and innate immunity." Philosophical Transactions of the Royal Society B: Biological Sciences 372, no. 1732 (September 11, 2017): 20160267. http://dx.doi.org/10.1098/rstb.2016.0267.
Повний текст джерелаTriantafilou, Martha, Philipp M. Lepper, Robin Olden, Ivo de Seabra Rodrigues Dias, and Kathy Triantafilou. "Location, Location, Location: Is Membrane Partitioning Everything When It Comes to Innate Immune Activation?" Mediators of Inflammation 2011 (2011): 1–10. http://dx.doi.org/10.1155/2011/186093.
Повний текст джерелаEades, Lauren, Michael Drozd, and Richard M. Cubbon. "Hypoxia signalling in the regulation of innate immune training." Biochemical Society Transactions 50, no. 1 (January 11, 2021): 413–22. http://dx.doi.org/10.1042/bst20210857.
Повний текст джерелаBoudsocq, Marie, Matthew R. Willmann, Matthew McCormack, Horim Lee, Libo Shan, Ping He, Jenifer Bush, Shu-Hua Cheng, and Jen Sheen. "Differential innate immune signalling via Ca2+ sensor protein kinases." Nature 464, no. 7287 (February 17, 2010): 418–22. http://dx.doi.org/10.1038/nature08794.
Повний текст джерелаZhang, Yaxing, Zan Huang, and Hongliang Li. "Insights into innate immune signalling in controlling cardiac remodelling." Cardiovascular Research 113, no. 13 (July 3, 2017): 1538–50. http://dx.doi.org/10.1093/cvr/cvx130.
Повний текст джерелаShadel, Gerald S. "Mitochondrial DNA stress in innate immune signalling and cancer." Biochimica et Biophysica Acta (BBA) - Bioenergetics 1857 (August 2016): e5-e6. http://dx.doi.org/10.1016/j.bbabio.2016.04.408.
Повний текст джерелаSprenger, Hans-Georg, Thomas MacVicar, Amir Bahat, Kai Uwe Fiedler, Steffen Hermans, Denise Ehrentraut, Katharina Ried, et al. "Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity." Nature Metabolism 3, no. 5 (April 26, 2021): 636–50. http://dx.doi.org/10.1038/s42255-021-00385-9.
Повний текст джерелаДисертації з теми "Innate immune signalling"
Watkinson, Ruth Elizabeth. "Intracellular antibody receptor TRIM21 in viral neutralisation and innate immune signalling." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708305.
Повний текст джерелаSchreuder, Lisa Jane. "Effects of Mycrobacteria on the Signalling Machinenary of Bovine Innate Immune Cells." Thesis, Royal Veterinary College (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499275.
Повний текст джерелаJan, Afnan. "A role for connexin signalling in the innate immune response in the skin." Thesis, Glasgow Caledonian University, 2016. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.726766.
Повний текст джерелаBilkei-Gorzo, Orsolya. "Ubiquitylation regulates vesicle trafficking and innate immune responses on the phagosome of inflammatory macrophages." Thesis, University of Dundee, 2018. https://discovery.dundee.ac.uk/en/studentTheses/8661922d-9d5e-4a4a-bfd4-b0f5e5717c61.
Повний текст джерелаGaughan, Daniel. "The role of DNA damage response proteins in innate immune signalling : a new role for BRCA1." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:252f589f-40c0-4f7f-be3d-124e588e92a8.
Повний текст джерелаHomem, Rafael Augusto. "Redox signalling and innate immunity : a role for protein S-nitrosylation in the immune response of Drosophila melanogaster." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/15971.
Повний текст джерелаReder, Gabor. "Development of a phosphoproteomic screen of innate immune signalling : identification and characterisation of a novel phosphorylation of NFkB1/p105." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6150.
Повний текст джерелаAnselm, Bettina [Verfasser], and Bianca [Akademischer Betreuer] Schaub. "Early priming of the immune system: Identifying predictive markers of innate immunity and calcium signalling for the development of asthma / Bettina Anselm ; Betreuer: Bianca Schaub." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1204827915/34.
Повний текст джерелаWestphal, Andreas [Verfasser], Kyeong-Hee [Akademischer Betreuer] Lee, Norbert [Akademischer Betreuer] Reiling, and Georgios [Akademischer Betreuer] Tsiavaliaris. "Lysosomal trafficking regulator Lyst controls innate immune cell signalling and function : regulation of TLR-mediated TRIF signalling and control of mast cell-mediated allergic reactions / Andreas Westphal ; Akademische Betreuer: Kyeong-Hee Lee, Norbert Reiling, Georgios Tsiavaliaris ; Institut für Klinische Chemie." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2017. http://d-nb.info/1143981758/34.
Повний текст джерелаCzerwińska, Urszula. "Unsupervised deconvolution of bulk omics profiles : methodology and application to characterize the immune landscape in tumors Determining the optimal number of independent components for reproducible transcriptomic data analysis Application of independent component analysis to tumor transcriptomes reveals specific and reproducible immune-related signals A multiscale signalling network map of innate immune response in cancer reveals signatures of cell heterogeneity and functional polarization." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB075.
Повний текст джерелаTumors are engulfed in a complex microenvironment (TME) including tumor cells, fibroblasts, and a diversity of immune cells. Currently, a new generation of cancer therapies based on modulation of the immune system response is in active clinical development with first promising results. Therefore, understanding the composition of TME in each tumor case is critically important to make a prognosis on the tumor progression and its response to treatment. However, we lack reliable and validated quantitative approaches to characterize the TME in order to facilitate the choice of the best existing therapy. One part of this challenge is to be able to quantify the cellular composition of a tumor sample (called deconvolution problem in this context), using its bulk omics profile (global quantitative profiling of certain types of molecules, such as mRNA or epigenetic markers). In recent years, there was a remarkable explosion in the number of methods approaching this problem in several different ways. Most of them use pre-defined molecular signatures of specific cell types and extrapolate this information to previously unseen contexts. This can bias the TME quantification in those situations where the context under study is significantly different from the reference. In theory, under certain assumptions, it is possible to separate complex signal mixtures, using classical and advanced methods of source separation and dimension reduction, without pre-existing source definitions. If such an approach (unsupervised deconvolution) is feasible to apply for bulk omic profiles of tumor samples, then this would make it possible to avoid the above mentioned contextual biases and provide insights into the context-specific signatures of cell types. In this work, I developed a new method called DeconICA (Deconvolution of bulk omics datasets through Immune Component Analysis), based on the blind source separation methodology. DeconICA has an aim to decipher and quantify the biological signals shaping omics profiles of tumor samples or normal tissues. A particular focus of my study was on the immune system-related signals and discovering new signatures of immune cell types. In order to make my work more accessible, I implemented the DeconICA method as an R package named "DeconICA". By applying this software to the standard benchmark datasets, I demonstrated that DeconICA is able to quantify immune cells with accuracy comparable to published state-of-the-art methods but without a priori defining a cell type-specific signature genes. The implementation can work with existing deconvolution methods based on matrix factorization techniques such as Independent Component Analysis (ICA) or Non-Negative Matrix Factorization (NMF). Finally, I applied DeconICA to a big corpus of data containing more than 100 transcriptomic datasets composed of, in total, over 28000 samples of 40 tumor types generated by different technologies and processed independently. This analysis demonstrated that ICA-based immune signals are reproducible between datasets and three major immune cell types: T-cells, B-cells and Myeloid cells can be reliably identified and quantified. Additionally, I used the ICA-derived metagenes as context-specific signatures in order to study the characteristics of immune cells in different tumor types. The analysis revealed a large diversity and plasticity of immune cells dependent and independent on tumor type. Some conclusions of the study can be helpful in identification of new drug targets or biomarkers for immunotherapy of cancer
Книги з теми "Innate immune signalling"
Geri, Guillaume, and Jean-Paul Mira. Host–pathogen interactions in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0306.
Повний текст джерелаMonaco, Claudia, and Giuseppina Caligiuri. Molecular mechanisms. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755777.003.0014.
Повний текст джерелаWinchester, Robert, Darren D. O’Rielly, and Proton Rahman. Genetics of psoriatic arthritis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0006.
Повний текст джерелаЧастини книг з теми "Innate immune signalling"
Mulhern, Orla, Barry Harrington, and Andrew G. Bowie. "Modulation of Innate Immune Signalling Pathways by Viral Proteins." In Pathogen-Derived Immunomodulatory Molecules, 49–63. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-1601-3_4.
Повний текст джерелаGalvão, Izabela, Lirlândia P. Sousa, Mauro M. Teixeira, and Vanessa Pinho. "PI3K Isoforms in Cell Signalling and Innate Immune Cell Responses." In Current Topics in Microbiology and Immunology, 147–64. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-06566-8_6.
Повний текст джерелаKuraishi, Takayuki, Hirotaka Kanoh, Yoshiki Momiuchi, Hiroyuki Kenmoku, and Shoichiro Kurata. "The Drosophila Toll Pathway: A Model of Innate Immune Signalling Activated by Endogenous Ligands." In Chronic Inflammation, 119–29. Tokyo: Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-56068-5_10.
Повний текст джерелаSchmid-Hempel, Paul. "The natural history of defences." In Evolutionary Parasitology, 51–108. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780198832140.003.0004.
Повний текст джерелаMarina Andrei, Ana, Elena Cristina Andrei, Elena Camelia Stănciulescu, Mihaela Cezarina Mehedinți, Mihaela Jana Țuculină, Ileana Monica Baniță, Sandra Alice Buteică, and Cătălina Gabriela Pisoschi. "Innate Immune Response as a New Challenge in Periodontal Inflammation." In Periodontology - Fundamentals and Clinical Features [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96801.
Повний текст джерелаKumar, Jitendra, Priya Sharma, Murli Dhar Mitra, Sonia Sangwan, and Haribrahma Singh. "Molecular Impact of Dietary Fibre Metabolites on Intestinal Immunity of Host." In Immunology of the GI Tract - Recent Advances. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.107348.
Повний текст джерелаDistler, Oliver, and Caroline Ospelt. "Rheumatoid arthritis: basic mechanisms in joints." In ESC CardioMed, 1109–12. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0271.
Повний текст джерелаSundar, Kothandapani, Ramachandira Prabu, and Gopal Jayalakshmi. "Quorum Sensing Inhibition Based Drugs to Conquer Antimicrobial Resistance." In The Global Antimicrobial Resistance Epidemic - Innovative Approaches and Cutting-Edge Solutions [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.104125.
Повний текст джерелаGomperts, Bastien D., IJsbrand M. Kramer, and Peter E. R. Tatham. "Activation of the Innate immune System: The Toll-like Receptor 4 and Signalling through Ubiquitylation." In Signal Transduction, 451–82. Elsevier, 2009. http://dx.doi.org/10.1016/b978-0-12-369441-6.00015-5.
Повний текст джерелаТези доповідей конференцій з теми "Innate immune signalling"
Marcec, Matthew. "Calcium and ROS signalling in plant innate immune responses." In ASPB PLANT BIOLOGY 2020. USA: ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1053034.
Повний текст джерелаLuo, X., M. Lu, HA Baba, G. Gerken, H. Wedemeyer, and R. Broering. "The Hippo signalling is induced by Toll-like receptor 4 activation and regulatory balance innate immune responses in liver cells." In 35. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0038-1677270.
Повний текст джерелаBirnhuber, A., S. Crnkovic, L. M. Marsh, V. Biasin, J. Wilhelm, W. Graninger, A. Olschewski, H. Olschewski, and G. Kwapiszewska. "Exacerbated Lung Function and Eosinophilic Inflammation After Blockage of Innate Immune Signalling in a Mouse Model of Systemic Sclerosis-Associated Lung Fibrosis." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3078.
Повний текст джерелаCipriani, Barbara, Alan Naylor, Gavin Milne, Barbara Young, Rupert Satchell, Sourav Sarkar, Zoe Smith, et al. "Abstract 1631: GPR65 is a critical mediator of low pH induced immunosuppressive signalling in tumor associated macrophages: Human target validation of GPR65 as a novel innate immune checkpoint and discovery of potent, selective GPR65 antagonists." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1631.
Повний текст джерела