Готові списки джерел за темами / Injectable Cement

Добірка наукової літератури з теми "Injectable Cement"

Автор: Grafiati

Опубліковано: 26 вересня 2023

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Статті в журналах з теми "Injectable Cement"

Medvecky, Lubomir, Radoslava Štulajterová, Maria Giretova, Lenka Luptakova, and Tibor Sopčák. "Injectable Enzymatically Hardened Calcium Phosphate Biocement." Journal of Functional Biomaterials 11, no. 4 (October 12, 2020): 74. http://dx.doi.org/10.3390/jfb11040074.

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(1) Background: The preparation and characterization of novel fully injectable enzymatically hardened tetracalcium phosphate/monetite cements (CXI cements) using phytic acid/phytase (PHYT/F3P) hardening liquid with a small addition of polyacrylic acid/carboxymethyl cellulose anionic polyelectrolyte (PAA/CMC) and enhanced bioactivity. (2) Methods: Composite cements were prepared by mixing of calcium phosphate powder mixture with hardening liquid containing anionic polyelectrolyte. Phase and microstructural analysis, compressive strength, release of ions and in vitro testing were used for the evaluation of cement properties. (3) Results: The simple possibility to control the setting time of self-setting CXI cements was shown (7–28 min) by the change in P/L ratio or PHYT/F3P reaction time. The wet compressive strength of cements (up to 15 MPa) was close to cancellous bone. The increase in PAA content to 1 wt% caused refinement and change in the morphology of hydroxyapatite particles. Cement pastes had a high resistance to wash-out in a short time after cement mixing. The noncytotoxic character of CX cement extracts was verified. Moreover, PHYT supported the formation of Ca deposits, and the additional synergistic effect of PAA and CMC on enhanced ALP activity was found, along with the strong up-regulation of osteogenic gene expressions for osteopontin, osteocalcin and IGF1 growth factor evaluated by the RT-qPCR analysis in osteogenic αMEM 50% CXI extracts. (4) Conclusions: The fully injectable composite calcium phosphate bicements with anionic polyelectrolyte addition showed good mechanical and physico-chemical properties and enhanced osteogenic bioactivity which is a promising assumption for their application in bone defect regeneration.

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Faris, Adam, Hakan Engqvist, Jesper Lööf, Mikael Ottosson, and Leif Hermansson. "In Vitro Bioactivity of Injectable Ceramic Orthopaedic Cements." Key Engineering Materials 309-311 (May 2006): 833–36. http://dx.doi.org/10.4028/www.scientific.net/kem.309-311.833.

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The objective of this paper is to investigate and compare the in vitro bioactivity of three injectable cements for orthopaedic applications. The cements were all based on chemically bonded ceramics technology; calcium phosphate (Norian SRS), and experimental versions of calcium silicate and calcium aluminate cements. The cements were mixed with their respective liquids and were after setting stored in phosphate buffered saline at 37 °C for time periods of 1h, 24 h, 7 days and 30 days. After storage the samples were analysed with scanning electron microscopy (SEM), thin film X-Ray diffraction (TF-XRD) and energy dispersive spectroscopy (EDS) for the presence of possible apatite on the sample surface. The SEM and EDX analyses showed that surface films containing Ca and P (along with the other atoms present in the materials) were formed on all materials. Thus reactions with the storage medium had occurred. The TF-XRD analysis confirmed the presence of apatite for the calcium phosphate cement and the calcium aluminate cement. On the calcium silicate cement most of the surface zone seemed to be amorphous with only broad peaks corresponding to apatite. Thus all the tested materials showed signs of in vitro bioactivity.

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Mao, Ke Zheng, Ke Ya Mao, Zi Shen Cheng, Peng Li, Zong Gang Chen, Xu Mei Wang, and Fu Zai Cui. "Performance of Composite Cements in the Repair of Porcine Thoracolumbar Burst Fracture In Vitro." Materials Science Forum 745-746 (February 2013): 13–20. http://dx.doi.org/10.4028/www.scientific.net/msf.745-746.13.

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Анотація:

An ideal injectable bone cement should be able to fill fully the fractures gap and provide good mechanical support. In the present work, the mineralized collagen and calcium sulphate dehydrate (CSD) was incorporated into α-calcium sulphate hemihydrates (α-CSH) to explore an injectable composite cement. The injectability, the setting time and the biomechanics properties were investigated. A porcine thoracolumbar burst fracture model was used to evaluate the biomechanical performance of composite cements. The porcine thoracolumbar burst fracture models in vitro were prepared. A half of models was made by the vertebroplasty of the composite cements, the other half of models was used as control. Imaging analysis showed the composite cements distributed uniformly and solidified well. Biomechanical test showed the ability of the composite cements to repair spinal burst fractures was significant.

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Konishi, Toshiisa, Michiyo Honda, Masaki Nagaya, Hiroshi Nagashima, Eng San Thian, and Mamoru Aizawa. "Injectable chelate-setting hydroxyapatite cement prepared by using chitosan solution: Fabrication, material properties, biocompatibility, and osteoconductivity." Journal of Biomaterials Applications 31, no. 10 (May 2017): 1319–27. http://dx.doi.org/10.1177/0885328217704060.

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An injectable chelate-setting hydroxyapatite cement (IP6-HAp), formed by chelate-bonding capability of inositol phosphate (IP6), was developed. The effects of ball-milling duration of starting HAp powder and IP6 concentration on the material properties such as injectability and mechanical strength of the cement were examined. The cement powder was prepared by ball-milling the as-synthesized HAp powder for 5 min using ZrO2 beads with a diameter of 10 mm, followed by another 60 min with ZrO2 beads with a diameter of 2 mm, and thereafter surface-modified with 5000 ppm of IP6 solution. Injectable cement was then fabricated with this HAp powder and 2.5 mass% chitosan as a mixing solution, with a setting time of 36.3 ± 4.7 min and a compressive strength of 19.0 ± 2.1 MPa. The IP6-HAp cements prepared with chitosan showed favorable biocompatibility in vitro using an osteoblast cell model, and osteoconductivity in vivo using a pig tibia model.

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Chen, Ling, Hong Xiang, Xiao Xi Li, Jian Dong Ye, Xiu Peng Wang, Lin Li, and Xi Mei Zhang. "Development of a New Injectable Calcium Phosphate Cement That Contains Modified Starch." Key Engineering Materials 330-332 (February 2007): 843–46. http://dx.doi.org/10.4028/www.scientific.net/kem.330-332.843.

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In this study modified starch were used as anti-washout promoters of injectable calcium phosphate cement (CPC) and the effects of the modified starch on the injectability, anti-washout performance, setting time, compressive strength, phase evolution and microstructure of this cement were investigated. The injectability of the cement was improved by adding the modified starch (0.5-2.0%). After mixing with modified starch (0.5-2.0%), the cement showed better anti-washout performance than that without modified starch after immersed and shaken in SBF. Especially, when the content of the modified starch was 1.0%, the remaining percentage of the cement was reached to 92.6%, but only 5.9% of the CPC paste remained and set for the sample without modified starch after shaken for 2 hrs. The compressive strength of cements significantly increased from 44 MPa to 54 MPa when 0.5% of modified starch was added. And a slight increase on the mechanical strength can be observed for other concentrations. Powder X-ray diffraction analysis revealed no significant difference for the conversion of the cement to hydroxyapatite for any concentrations of modified starches. The influence of the modified starch on the microstructure of the set cement was also studied. The results showed the modified starch would reduce the acicular crystal size of hydroxyapatite accompanied with little flaky crystals generation and made a compact structure. It is concluded that modified starch, a suitable anti-washout promoter, improved the performance of CPC.

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Gonçalves, S., A. Brouchet, M. Frèche, F. Rodriguez, B. Delisle, and J. L. Lacout. "Formulation of an Injectable Phosphocalcium Cement." Key Engineering Materials 192-195 (September 2000): 789–92. http://dx.doi.org/10.4028/www.scientific.net/kem.192-195.789.

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Yousefi, Azizeh-Mitra. "A review of calcium phosphate cements and acrylic bone cements as injectable materials for bone repair and implant fixation." Journal of Applied Biomaterials & Functional Materials 17, no. 4 (October 2019): 228080001987259. http://dx.doi.org/10.1177/2280800019872594.

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Анотація:

Treatment of bone defects caused by trauma or disease is a major burden on human healthcare systems. Although autologous bone grafts are considered as the gold standard, they are limited in availability and are associated with post-operative complications. Minimally invasive alternatives using injectable bone cements are currently used in certain clinical procedures, such as vertebroplasty and balloon kyphoplasty. Nevertheless, given the high incidence of fractures and pathologies that result in bone voids, there is an unmet need for injectable materials with desired properties for minimally invasive procedures. This paper provides an overview of the most common injectable bone cement materials for clinical use. The emphasis has been placed on calcium phosphate cements and acrylic bone cements, while enabling the readers to compare the opportunities and challenges for these two classes of bone cements. This paper also briefly reviews antibiotic-loaded bone cements used in bone repair and implant fixation, including their efficacy and cost for healthcare systems. A summary of the current challenges and recommendations for future directions has been brought in the concluding section of this paper.

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Koju, Naresh, Prabaha Sikder, Bipin Gaihre, and Sarit B. Bhaduri. "Smart Injectable Self-Setting Monetite Based Bioceramics for Orthopedic Applications." Materials 11, no. 7 (July 22, 2018): 1258. http://dx.doi.org/10.3390/ma11071258.

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The present study is the first of its kind dealing with the development of a specific bioceramic which qualifies as a potential material in hard-tissue replacements. Specifically, we report the synthesis and evaluation of smart injectable calcium phosphate bone cement (CPC) which we believe will be suitable for various kinds of orthopedic and spinal-fusion applications. The smart nature of this next generation orthopedic implant is attained by incorporating piezoelectric barium titanate (BT) particles into monetite-based (dicalcium phosphate anhydrous, DCPA) CPC composition. The main goal is to take advantage of the piezoelectric properties of BT, as electromechanical effect plays a vital role in fracture healing at the defect site and bone integration with the implant. Furthermore, radiopacity of BT would help in easy detection of the CPC presence at the fracture site during surgery. Results reveal that BT addition favors important properties of bone cement such as good compressive strength, injectability, bioactivity, biocompatibility, and even washout resistance. Most importantly, the self-setting nature of the bone cements are not compromised with BT incorporation. The in vitro results confirm that the developed bone-cement abides by the standard orthopedic requirements making it apt for real-time prosthetic materials.

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Wu, Karl, Yu-Chun Chen, Shang M. Lin, and Chih-Hung Chang. "In vitro and in vivo effectiveness of a novel injectable calcitonin-loaded collagen/ceramic bone substitute." Journal of Biomaterials Applications 35, no. 10 (January 31, 2021): 1355–65. http://dx.doi.org/10.1177/0885328221989984.

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This study aimed to evaluate the effectiveness of a novel calcitonin-loaded calcium phosphate composite bone cement in vitro and in vivo. The novel composite bone cements were composed of NuROs injectable bone graft substitute, type I collagen, and/or salmon calcitonin. The setting time, porosity, wettability, compressive strength, compressive modulus, and crystallographic structures of cement specimens were determined. Degradation rate, calcitonin release rate, and osteoinductivity were assessed in vitro. In addition, osteogenic effect was examined in a rabbit model of femoral defect. The results revealed that addition of collagen/calcitonin did not substantially alter physical properties and degradation rate of bone cement specimens. Calcitonin was released into culture medium in a two-phase manner. Osteogenic effect of conditioned medium derived from calcitonin containing bone cement was observed. Finally, de novo bone growth and bone mineralization across the bone defect area were observed in rabbits after implantation of composite bone cement specimens. In conclusion, this novel calcitonin-loaded composite calcium phosphate bone cement exhibits biocompatibility, bioresorbability, osteoinductivity, and osteoconductivity, which may be suitable for clinical use.

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Krokhicheva, P. A., M. A. Goldberg, D. R. Khairutdinova, A. S. Fomin, A. V. Kondratiev, A. S. Baikin, A. V. Leonov, et al. "Cementing materials based on magnesium and calcium phosphates with sodium hyaluronate." Perspektivnye Materialy 9 (2022): 45–55. http://dx.doi.org/10.30791/1028-978x-2022-9-45-55.

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Анотація:

In the recent years, a magnesium-calcium phosphate materials are considered as an alternative to materials based on the calcium phosphates in the reconstructive surgery. The injectable bone cements have been particular interest for the minimally invasive surgical approaches. The aim of this work is considered to the creating and studying of the structural-phase state of cement materials based on the Newberite phase (MgHPO4·3H2O). The addition of a polymer - sodium hyaluronate in the cement fluid, based on a sodium phosphate solution, leeds to the increasing of the viscosity of the system, thereby increasing the cohesion of cement materials. The effect of addition sodium hyaluronate in the various concentrations on the phase composition, setting time, pH value, microstructure, injectability and strength properties of cement materials has been studied.

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Більше джерел

Дисертації з теми "Injectable Cement"

López, Alejandro. "Injectable Biomaterials for Spinal Applications." Doctoral thesis, Uppsala universitet, Institutionen för teknikvetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-215606.

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The use of injectable biomaterials is growing as the demands for minimally invasive procedures, and more easily applicable implants become higher, but their availability is still limited due to the difficulties associated to their design. Each year, more than 700,000 vertebral compression fractures (VCF’s) are reported in the US and 500,000 VCF’s in Europe due to primary osteoporosis only. VCF’s can compromise the delicacy of the spinal canal and also cause back pain, which affects the patient’s quality of life. Vertebroplasty was developed in the 80’s, and has proven to be a safe minimally invasive procedure that can, quickly and sustainably, relieve the pain in patients experiencing VCF’s. However, biomaterials for vertebroplasty still have limitations. For instance, ceramic bone cements are difficult to distinguish from the bone using X-ray techniques. On the other hand, acrylic bone cements may cause adjacent vertebral fractures (AVF’s). Large clinical studies have indicated that 12 to 20% vertebroplasty recipients developed subsequent vertebral fractures, and that 41 to 67% of these, were AVF’s. This may be attributed to the load shifting and increased pressure on the adjacent endplates reached after vertebroplasty with stiff cements. The primary aim of this thesis was to develop better injectable biomaterials for spinal applications, particularly, bone cements for vertebroplasty. Water-soluble radiopacifiers were first investigated to enhance the radiopacity of resorbable ceramic cements. Additionally, different strategies to produce materials that mechanically comply with the surrounding tissues (low-modulus bone cements) were investigated. When a suitable low-modulus cement was produced, its performance was evaluated in both bovine bone, and human vertebra ex vivo models. In summary, strontium halides showed potential as water-soluble radiocontrast agents and could be used in resorbable calcium phosphates and other types of resorbable biomaterials. Conversely, linoleic acid-modified (low-modulus) cements appeared to be a promising alternative to currently available high-modulus cements. It was also shown that the influence of the cement properties on the strength and stiffness of a single vertebra depend upon the initial bone volume fraction, and that at low bone volume fractions, the initial mechanical properties of the vertebroplasty cement become more relevant. Finally, it was shown that vertebroplasty with low-modulus cements is biomechanically safe, and could become a recommended minimally invasive therapy in selected cases, especially for patients suffering from vertebral compression fractures due to osteoporosis.

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Saadalla, Marco Edward. "A new modified injectable brushite-based calcium phosphate bone cement." Thesis, Queen Mary, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498084.

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Gonçalves, Luís Pedro Valente. "Ready to use injectable bone substitutes." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/17462.

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Mestrado em Materiais e Dispositivos Biomédicos
In recent years, the development and innovation of new bone substitutes has revolutionized the lives of millions of patients. The aim of this work is the development and characterization of a bioactive, injectable and ready-to-use system (also called putty or premixed cement) for bone regeneration. The solid phase is constituted by beta-tricalcium phosphate (β-TCP), FastOs® bioglass (FastOs® BG) and monocalcium phosphate monohydrate (MCPM) powders, while the liquid phase comprises glycerol (G). The synthesis of β-TCP powder was obtained by precipitation reactions followed by heat-treatment; FastOs® BG was obtained by melt-quenching. The characterization of the obtained powders was made through X-ray diffraction (XRD) and measurement of the mean particle sizes and particle size distribution. The putty was prepared by mixing the solid and liquid phases and placed in syringes with a screw cap. Regarding clinical application, injectability, setting time (ST) and mechanical strength were investigated to characterize the putty. Structural analyses of the putty were also performed by XRD, Fourier Tranform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The putty has a solid/liquid weight ratio (S/L) of 3.3, mean ST of ~25 min, ~96% of injectability and a maximum compressive strength of 6 MPa. Therefore, the putty exhibited excellent injectability results, absence of filter pressing effect and acceptable mechanical properties. The structural analysis of the hardened cements revealed the formation of monetite crystals covered by an amorphous apatitic layer after immersion in PBS and water. The results are encouraging and support the conclusion that ready-to-use injectable bone substitutes have excellent handling properties to be used clinically. In accordance with the Directive 93/42/EEC the putty is considered a class III medical device. In order to pave the way towards its commercial release and in order to meet the essential requirements set out in Annex I of the Directive 93/42/EEC, a clinical evaluation has been carried out.
Nos últimos anos, o desenvolvimento e a inovação de novos substitutos ósseos tem revolucionado a vida de milhões de doentes. O objetivo deste trabalho é o desenvolvimento e caracterização de um sistema bioativo, injectável e pronto-a-usar (putty) para regeneração óssea. A fase sólida é constituída por pós de fosfato tricálcico beta (β-TCP), biovidro FastOs (FastOs®BG) e fosfato monocálcico monohidratado (MCPM), enquanto a fase líquida é o glicerol (G). A síntese dos pós de β-TCP foi obtida por reações de precipitação seguida de tratamento térmico; os pós de FastOs®BG foram obtidos por fusão e arrefecimento em água fria (fritagem) (melt-quenching). A caracterização dos pós foi feita por difracção de raios-X (XRD) e medição dos tamanhos de partícula. O sistema injectável pronto-a-usar foi preparado através da mistura das fases sólida e líquida e colocado em seringas seladas com tampa roscada. Do ponto de vista de aplicação clínica, o sistema foi caracterizado tendo em conta a sua injectabilidade, tempo de presa (setting time, ST) e resistência mecânica. A análise estrutural do sistema também foi realizada, através de XRD, espectroscopia de infravermelho com transformada de Fourier (FTIR) e microscopia eletrónica de varrimento (SEM). O sistema injectável pronto-a-usar tem uma razão em peso sólido/líquido (S/L) de 3,3, um ST médio de ~25 min, ~96% de injectabilidade, e 6 MPa de resistência máxima à compressão. Deste modo, o sistema injetável demonstrou excelentes resultados de injectabilidade, tendo-se verificado ainda a ausência do efeito de filter pressing e propriedades mecânicas aceitáveis. A análise estrutural dos cimentos endurecidos revelou a formação de cristais de monetite recobertos por uma camada apatítica amorfa após imersão em PBS e em água. Os resultados obtidos são promissores e permitem concluir que o sistema injetável pronto-a-usar possui excelentes propriedades de manipulação do ponto de vista clínico. De acordo com a Directiva 93/42/CEE o sistema injetável é considerado um dispositivo médico de classe III. Com o objectivo de contribuir para o seu processo de lançamento comercial e seguindo os requisitos essenciais estabelecidos no anexo I da Directiva 93/42/CEE foi elaborado um relatório tendo em conta a avaliação clínica do sistema injectável.

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Ruskin, Ethel Ibinabo. "Magnetic Injectable Self-setting Calcium Phosphate Cement (CPC) Compositionsfor Hyperthermia Treatment of Bone Tumors." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1544628961078107.

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Oliveira, Maria Teresa Carvalho. "Development of a large animal model for percutaneous vertebroplasty for in vivo evaluation of a new injectable cement." Doctoral thesis, Universidade de Évora, 2017. http://hdl.handle.net/10174/21279.

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Анотація:

The present work aimed to test in vivo a new biomaterial for vertebral augmentation. Vertebral compression fractures not healing with conservative management are treated through minimally invasive surgical techniques. Presently, most of the cements used in percutaneous bone interventions are based on a polymeric non-resorbable matrix. However, they can present some complications. Calcium suphate-based cements are effective bone substitutes. Disadvantages include their limited shear and compressive strength. To go beyond the state of the art, a new bioactive calcium sulphate-based cement was developed - Spine-Ghost. To test the suitability of the injectable cement for percutaneous vertebroplasty, a preclinical study was mandatory. A new large animal model for percutaneous vertebroplasty was developed in sheep. In the ex vivo model, bone defects were created in the cranial hemivertebrae through a bilateral modified parapedicular approach, and mechanical tests were performed. The ex vivo model is reproducible, and safe under physiological loads. In the in vivo study, two groups of Merino sheep were defined (n=8): a) the control group, injected with a commercial ceramic cement; and b) the experimental group, injected with Spine-Ghost. Of the first interventioned animals, two presented cardiorespiratory distress during the cement injection, and one had mild neurologic deficits in the hindlimbs. All sheep survived and completed the 6-month implantation period. After sacrifice, the samples were assessed by micro-computed tomography, histological, histomorphometric, and immunohistological studies. There was no evidence of cement leakage into the vertebral foramen. No signs of infection or inflammation were observed. Most importantly, there was cement resorption and new trabecular bone formation in the bone defects of all sheep. The model of percutaneous vertebroplasty is considered suitable for preclinical in vivo studies, mimicking clinical application. Spine-Ghost proved to be an adequate material for percutaneous vertebroplasty, with a biological response identical, if not superior, to the one elicited by the available commercial control; Desenvolvimento de modelo animal superior para vertebroplastia percutânea para avaliação in vivo de um novo cimento injetável. Sumário: O trabalho aqui apresentado teve por objetivo a avaliação in vivo de um novo biomaterial injetável para vertebroplastia a cifoplastia percutâneas. As fraturas de compressão vertebral com indicação cirúrgica são tratadas com recurso a técnicas minimamente invasivas. Presentemente, a maioria dos cimentos utilizados baseiam-se numa matriz polimérica não reabsorvível. Podem, no entanto, causar algumas complicações. Os cimentos à base de sulfato de cálcio são substitutos ósseos eficazes, cujas desvantagens incluem resistência limitada a esforços de corte e compressão. Um novo cimento bioativo de sulfato de cálcio - Spine-Ghost - foi desenvolvido. Para testar a sua aplicabilidade na vertebroplastia percutânea, tornou-se imperativo um estudo pré- clínico. Para o efeito, um novo modelo animal para vertebroplastia percutânea foi desenvolvido em ovinos e sujeito a ensaios mecânicos. No modelo ex vivo, foram criados bilateralmente dois defeitos ósseos interligados, nas hemivértebras craniais, através de uma abordagem parapedicular modificada. O modelo ex vivo é reprodutível e seguro sob cargas fisiológicas. No estudo in vivo, definiram-se dois grupos de ovelhas Merino (n=8): a) grupo controlo, injetado com cimento comercial de base cerâmica; b) grupo experimental, injetado com Spine-Ghost. Nos primeiros animais intervencionados, dois apresentaram alterações cardiorrespiratórias durante a injeção de cimento, e um défices neurológicos ligeiros nos membros pélvicos. Todos os animais sobreviveram e completaram o período de implantação de 6 meses. Após a ocisão, as amostras foram avaliadas por microtomografia computorizada, histologia, histomorfometria e imunohistoquímica. Não se observou derrame de cimento para o canal vertebral, nem sinais de infeção ou inflamação. Ademais, verificou-se a reabsorção do cimento e a neoformação de tecido ósseo trabecular no interior dos defeitos ósseos, em todos os animais. O modelo de vertebroplastia percutânea é considerado adequado para estudos pré- clínicos, mimetizando a aplicação clínica. O Spine-Ghost demonstrou ser um biomaterial adequado para vertebroplastia percutânea, com uma resposta biológica idêntica, se não superior, à elicitada pelo controlo comercial.

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Barou, Carole. "Conception d'un ciment à base de phosphates de calcium pour la reconstruction osseuse et la libération de médicaments." Electronic Thesis or Diss., Montpellier, Ecole nationale supérieure de chimie, 2022. http://www.theses.fr/2022ENCM0019.

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Анотація:

Le traitement de l'os est un enjeu majeur en vue des difficultés de l'os à se réparer seul. Plusieurs situations chirurgicales exige l'utilisation d'auto- et/ou allogreffes. Le traitement par autogreffe est celui choisi par prédilection pour la reconstruction osseuse, car elle permet la croissance osteoinductive, fournit les cellules osteogéniques et le scaffold osteoconductif. Cependant cette voie présente de nombreuses limitations telles que la morbidité du site donneur, le temps d'opération allongé, l'insufficance en quantité... Il est ainsi nécessaire de développer de nouvelles stratégies thérapeutiques capables d'exploiter le pouvoir naturel régénérant de l'os et d'être délivré de manière moins invasive. Parmi les matériaux étudiés pour le développement de nouveaux scaffolds, les ciments phosphocalciques fournissent de larges avantages concernant les perfomances biologiques : biocompatibilité, ostéoconduction, biorésorption, bioactivité... L'idée de ce projet est de développer et caractériser un nouveau ciment phosphocalcique pour la régénération osseuse. Le but est d'aboutir sur un procédé original pour obtenir un scaffold injectable, chargé en principe actif pour ensuite être délivré localement. L'atout majeur de cette structure est sa similarité avec la composition de l'os et ses propriétés mécaniques
The treatment of bone is a challenge due to the difficulty that has the bone to repair itself. Several surgical situations sometimes require the application of auto- and allografts. Autologous bone grafting is the gold-standard treatment for bone reconstruction as it is the only that can provide osteoinductive growth factors, osteogenic cells and osteoconductive scaffold. These procedures present many limitations including donor site morbidity, increased operative time and providing insufficient quantity or quality. There is therefore a need to develop novel therapeutic strategies able to exploit the natural regenerative potential of bone and that can be delivered in a less invasive manner. Among the materials studied for the development of novel scaffolds, calcium phosphate cements provide many advantages due to its biological performances, including their biocompatibility, osteoconductivity, osteoinductivity, biodegradability, bioactivity, and interactions with cells. The aim of this thesis is the development and characterization of novel calcium phosphate based cements for bone regeneration. Our goal is to develop new original processes for the development of injectable scaffolds. The major advantage of such structures lies in the perfect biocompatibility with the mechanical properties similar to those of bone

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Jacquart, Sylvaine. "Substitut osseux injectable, antibactérien et résorbable : études physico-chimiques et biologiques d'un ciment composite à base d'apatite." Thesis, Toulouse, INPT, 2013. http://www.theses.fr/2013INPT0079/document.

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Анотація:

Ce travail porte sur la recherche et le développement d'un matériau de substitution osseuse permettant une implantation par chirurgie mini invasive, limitant les infections post-opératoires et dont la résorbabilité serait adaptée à la cinétique de régénération osseuse. Nous nous sommes intéressés à un ciment à base de carbonate et de phosphate de calcium (CaCO3 – CaP) dont la réaction de prise conduit à la formation d'une apatite nanocristalline analogue au minéral osseux. Dans une première partie la cinétique de prise et le produit de réaction ont été caractérisés par différentes techniques, notamment la diffraction des RX et les spectroscopies FTIR et RMN du solide. Un sel d'argent – Ag3PO4 ou AgNO3, choisis pour leurs propriétés antibactériennes – a été ensuite introduit dans la formulation. Son effet sur la cinétique de la réaction chimique de prise a été mis en évidence par traitement des spectres FTIR et RMN et un mécanisme réactionnel original impliquant les ions argent et nitrate dans la formation de l'apatite a été proposé. L'ajout d'un polysaccharide, la carboxyméthylcellulose (CMC), dans la phase solide du ciment a montré une très nette amélioration de l'injectabilité de la pâte, avec la disparition du phénomène de séparation des phases qui limite généralement l'injectabilité des ciments minéraux. La résistance à la compression et le module élastique des ciments composites ont été par ailleurs augmentés, parallèlement à une diminution de leur porosité. Différentes études in vitro en présence de cellules ou de bactéries ont enfin été réalisées et ont mis en évidence respectivement la cytocompatibilité des différentes compositions de ciments étudiées et le caractère antibactérien de ces matériaux à partir d'une certaine concentration en argent. L'implantation in vivo de compositions choisies a présenté des résultats très prometteurs quant à la résorbabilité d'un ciment composite CaCO3 - CaP/CMC/Ag et à la néoformation osseuse
The present work concerns research and development of a material for bone substitution, enabling implantation through a mini-invasive surgery, limiting post-operative infections and whose resorbability is adapted to bone regeneration kinetics. This study focused on a calcium carbonate and phosphate based cement, whose setting reaction leads to the formation of a nanocrystalline apatite, similar to bone mineral. First, the setting kinetics and the reaction products were characterised using different techniques, especially X-ray diffraction and FTIR and solid-state NMR spectroscopies. A silver salt – Ag3PO4 or AgNO3, chosen for their antibacterial properties – was then introduced in the formulation. Its effect on the setting reaction kinetics was revealed by data processing of FTIR and NMR spectra and an original reaction mechanism which involves silver and nitrates in the formation of apatite was proposed. The addition of a polysaccharide, carboxymethylcellulose (CMC), in the solid phase of the cement showed a clear improvement of the injectability of the paste, preventing the occurrence of filter-pressing phenomenon, often limiting the injectability of mineral cements. The resistance to compressive strength and elastic modulus of the composite cement were also improved together with a decrease in their porosity. Different in vitro studies were carried out in the presence of cells or bacteria and demonstrated the cytocompatibility of different cement compositions and their antibacterial properties starting at a certain silver concentration, respectively. In vivo implantation of selected compositions showed promising results concerning resorbability of a composite CaCO3 - CaP/CMC/Ag cement and the associated bone neoformation

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Valová, Kristýna. "Reologické vlastnosti modifikovaných polymer-kompozitních kostních past." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2018. http://www.nusl.cz/ntk/nusl-438888.

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Анотація:

Předložená diplomová práce je zaměřená na studium viscoelastického chování kostních past na bázi fosforečnanu vápenatého a vodného roztoku termosenzitivního triblokového kopolymeru, zlepšujícího tokové vlastnosti pasty. V teoretické části je zpracována stručná charakteristika cementů na bázi fosforečnanu vápenatého. Rovněž se zabývá charakteristikou reologických vlastností injektabilních kostních past. Součástí je také stručný přehled aditiv ovlivňujících právě reologické a mechanické vlastnosti past. Experimentální část je zaměřena na charakterizaci triblokového kopolymeru pomocí nukleární magnetické rezonanční spektroskopie a reologie. Dále byly připravovány modifikované fosfátové cementy, u kterých byly posléze studovány viskoelastické vlastnosti. Kostní pasta byla modifikována přídavkem adhezivních sloučenin (dopamin a jodičnan sodný) a antibakteriálním činidlem (selenové nanočástice). Analýza viskoelastických vlastností byla provedena reologickou analýzou, během níž byl primárně sledován proces vytvrzování a tixotropní chování jak nemodifikovaných, tak modifikovaných fosfátových past. Proces vytvrzování probíhal při teplotě 23 °C a 37 °C, imitující fyziologické prostředí. Morfologie fosfátové keramiky byla charakterizována pomocí rastrovací elektronové mikroskopie a velikost částic byla zjištěna pomocí laserového analyzátoru částic. Bylo prokázáno, že výše zmíněná aditiva mají pozitivní vliv na kinetiku procesu vytvrzování kostních past. Selenové nanočástice navíc vylepšily tixotropní chování polymer-fosfátových past. Z tohoto důvodu jsou tyto nové injektabilní kompozitní pasty vhodné pro miniinvazivní chirurgii. Díky aditivům, vykazujících adhezivní vlastnosti, mají potenciál uplatnit se při léčbě zlomenin. Stejně tak se nabízí možnost využít pasty při léčbě osteomyelitidy, a to díky možnému uvolňování antibakteriálních nanočástic.

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O'Hara, Rochelle. "Injectable calcium phosphate cements for spinal repair." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534586.

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Brunner, Tobias J. "Application of nanoparticulate biomaterials for injectable bone cements and dental repair." kostenfrei kostenfrei, 2007. http://e-collection.ethbib.ethz.ch/view/eth:30076.

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Частини книг з теми "Injectable Cement"

McNally, Alex, Kurt Sly, Steve Lin, Xavier Bourges, and Guy Daculsi. "Release of Antibiotics from Macroporous Injectable Calcium Phosphate Cement." In Bioceramics 20, 359–962. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-457-x.359.

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Liu, Jing, and Liting Yi. "Phase Changeable Liquid Metal as Injectable and Reversible Bone Cement." In Liquid Metal Biomaterials, 215–36. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-5607-9_10.

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Dong, Li Min, Chen Wang, Rui Liu, Jie Mo Tian, and Qing Feng Zan. "In Vivo Behavior of Injectable Fast-Setting Calcium Phosphate Cement." In Key Engineering Materials, 1625–27. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-410-3.1625.

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Trantolo, Debra J., Kai-Uwe Lewandrowski, Joseph D. Gresser, and Donald L. Wise. "Injectable and Bioresorbable Poly(Propylene Glycol-Co-Fumaric Acid) Bone Cement." In Biomaterials Engineering and Devices: Human Applications, 291–308. Totowa, NJ: Humana Press, 2000. http://dx.doi.org/10.1007/978-1-59259-197-8_18.

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Chen, Ling, Hong Xiang, Xiao Xi Li, Jian Dong Ye, Xiu Peng Wang, Lin Li, and Xi Mei Zhang. "Development of a New Injectable Calcium Phosphate Cement That Contains Modified Starch." In Key Engineering Materials, 843–46. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-422-7.843.

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Gong, J. Y., Shu Xin Qu, Q. Cui, and Jie Weng. "Development of Injectable Calcium Phosphate Cement Adding with ZrO₂." In Bioceramics 20, 347–50. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-457-x.347.

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Li, Dong Xiao, Q. Yao, Hong Song Fan, Ji Yong Chen, Yu Mei Xiao, Bo Zhang, and Xing Dong Zhang. "Preparation and In Vitro Releasing of Salmon Calcitonin Carried Porous Injectable Calcium Phosphate Bone Cement." In Bioceramics 18, 865–68. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/0-87849-992-x.865.

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Ye, Jian Dong, Xiu Peng Wang, and Ying Jun Wang. "Rheological Properties of an Injectable Calcium Phosphate Bone Cement and their Relationship with the Phase Evolution." In Key Engineering Materials, 1658–61. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-410-3.1658.

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Jouan, Gaelle, Eric Goyenvalle, Eric Aguado, Ronan Cognet, Françoise Moreau, Xavier Bourges, and Guy Daculsi. "PL DLLA Calcium Phosphate Composite Combined with Macroporous Calcium Phosphate Cement MCPC® for New Surgical Technologies Combining Resorbable Osteosynthesis and Injectable Bone Substitute." In Bioceramics 20, 411–14. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-457-x.411.

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Chen, Fangping, Yuanman Yu, Xiaoyu Ma, and Changsheng Liu. "Injectable Calcium Phosphate Cements for Hard Tissue Repair." In Springer Series in Biomaterials Science and Engineering, 147–86. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-5975-9_3.

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Тези доповідей конференцій з теми "Injectable Cement"

Kapici, Ibrahim, and Fende Sermin Utku. "A study on injectable bone cement." In 2017 Medical Technologies National Congress (TIPTEKNO). IEEE, 2017. http://dx.doi.org/10.1109/tiptekno.2017.8238059.

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Asaoka, Nobuyuki, Motohiko Misago, Masahiro Hirano, and Hiroyasu Takeuchi. "MECHANICAL AND CHEMICAL PROPERTIES OF THE INJECTABLE CALCIUM PHOSPHATE CEMENT." In Proceedings of the 12th International Symposium on Ceramics in Medicine. WORLD SCIENTIFIC, 1999. http://dx.doi.org/10.1142/9789814291064_0126.

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Sekine, Kazumitsu, Minoru Sakama, and Kenichi Hamada. "Evaluation of strontium introduced apatite cement as the injectable bone substitute developments." In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2013. http://dx.doi.org/10.1109/embc.2013.6609636.

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