Добірка наукової літератури з теми "Injectable bone filler"
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Статті в журналах з теми "Injectable bone filler"
Axén, Niklas, Tobias Persson, Kajsa Björklund, Hakan Engqvist, and Leif Hermansson. "An Injectable Bone Void Filler Cement Based on Ca-Aluminate." Key Engineering Materials 254-256 (December 2003): 265–68. http://dx.doi.org/10.4028/www.scientific.net/kem.254-256.265.
Повний текст джерелаDvorzhinskiy, Aleksey, Giorgio Perino, Robert Chojnowski, Marjolein C. H. van der Meulen, Mathias P. G. Bostrom, and Xu Yang. "Ceramic composite with gentamicin decreases persistent infection and increases bone formation in a rat model of debrided osteomyelitis." Journal of Bone and Joint Infection 6, no. 7 (July 20, 2021): 283–93. http://dx.doi.org/10.5194/jbji-6-283-2021.
Повний текст джерелаGumbiner, Brandon, Elizabeth Jacobsen, Mary Stancukas, and Ngan Nguyen. "A Rare Case of Chondroblastoma with Revision After Graft Rejection." Journal of the American Podiatric Medical Association 107, no. 5 (September 1, 2017): 440–45. http://dx.doi.org/10.7547/15-216.
Повний текст джерелаSchmidt, Luis Eduardo, Henrique Hadad, Igor Rodrigues de Vasconcelos, Luara Teixeira Colombo, Rodrigo Capalbo da Silva, Ana Flavia Piquera Santos, Lara Cristina Cunha Cervantes, et al. "Critical Defect Healing Assessment in Rat Calvaria Filled with Injectable Calcium Phosphate Cement." Journal of Functional Biomaterials 10, no. 2 (May 13, 2019): 21. http://dx.doi.org/10.3390/jfb10020021.
Повний текст джерелаDaculsi, G., M. Durand, T. Fabre, F. Vogt, A. P. Uzel, and J. L. Rouvillain. "Development and clinical cases of injectable bone void filler used in orthopaedic." IRBM 33, no. 4 (September 2012): 254–62. http://dx.doi.org/10.1016/j.irbm.2012.06.001.
Повний текст джерелаKochi, Akinori, Masanori Kikuchi, Yuki Shirosaki, Satoshi Hayakawa, and Akiyoshi Osaka. "Preparation of Injectable Hydroxyapatite/Collagen Nanocomposite Artificial Bone." Key Engineering Materials 493-494 (October 2011): 689–92. http://dx.doi.org/10.4028/www.scientific.net/kem.493-494.689.
Повний текст джерелаLayrolle, Pierre, Serge Baroth, Eric Goyenvalle, Eric Aguado, Françoise Moreau, and G. Daculsi. "In Vivo Performance of an Injectable Biphasic Calcium Phosphate Bone Filler." Key Engineering Materials 396-398 (October 2008): 583–86. http://dx.doi.org/10.4028/www.scientific.net/kem.396-398.583.
Повний текст джерелаBreding, Karin, and Hakan Engqvist. "Strength and Chemical Stability Due to Aging of Two Bone Void Filler Materials." Key Engineering Materials 361-363 (November 2007): 315–18. http://dx.doi.org/10.4028/www.scientific.net/kem.361-363.315.
Повний текст джерелаKotrych, Daniel, Szymon Korecki, Paweł Ziętek, Bartosz Kruk, Agnieszka Kruk, Michał Wechmann, Adam Kamiński, Katarzyna Kotrych, and Andrzej Bohatyrewicz. "Preliminary results of Highly Injectable Bi-Phasic Bone Substitute (CERAMENT) in the treatment of benign bone tumors and tumor-like lesions." Open Medicine 13, no. 1 (October 22, 2018): 487–92. http://dx.doi.org/10.1515/med-2018-0072.
Повний текст джерелаPurwiandono, Gani, Hera Julita, and Dita Adi Saputra. "Pengaruh Variasi HA-TCP (Hydroxy Apatit-Tricalcium Pospat) Terhadap Biokomposit (HA:TCP)-Gelatin-CMC Sebagai Injectable Bone Subtitute (IBS)." Chemical 4, no. 1 (February 8, 2018): 24–30. http://dx.doi.org/10.20885/ijcr.vol3.iss1.art4.
Повний текст джерелаДисертації з теми "Injectable bone filler"
Toppazzini, Mila. "Micrometer-scale systems for regenerative medicine applications." Doctoral thesis, Università degli studi di Trieste, 2010. http://hdl.handle.net/10077/3616.
Повний текст джерелаLa medicina rigenerativa applicata al campo ortopedico è considerata una possibile opzione terapeutica per la riparazione del tessuto osseo danneggiato. Si stanno studiano e sviluppando una gran varietà di sostituti ossei sintetici come valida alternativa agli innesti di tipo tissutale. Lo scopo di questo lavoro di tesi è la progettazione e lo sviluppo di un materiale iniettabile per il riempimento dei difetti ossei. In particolare abbiamo sviluppato un riempitivo composito iniettabile usando materiali biodegradabili di tipo polisaccaridico funzionalizzati con elementi bioattivi come mediatori dell’adesione cellulare, fattori di crescita osteoinduttivi e peptidi di tipo antimicrobico. Il costrutto finale è un composito a due fasi, le cui parti, inizialmente, sono state sviluppate separatamente. La struttura è stata progettata come composta da una parte bioattiva, costituita da microsfere disidratate di alginato e idrossiapatite recanti peptidi, immersa in una matrice veicolante rappresentata da una soluzione concentrata di acido ialuronico. Con lo scopo di ottenere le microsfere bioattive, sono state esplorate diverse tecniche per la coniugazione peptide-polisaccaride e sono stati presi in considerazione svariati sistemi di rilascio di sequenze peptidiche. In particolare sono stati considerati tre peptidi noti per la loro bioattività: peptidi di tipo RGD, sequenza favorente l’adesione cellulare, un frammento della proteina BMP-2 (bone morphogenetic protein-2) in grado di promuovere il differenziamento di cellule mesenchimali ad osteoblasti e LL-37 peptide antimicrobico umano. Per ottenere un costrutto con proprietà bioadesive, gli sforzi sono stati volti ad un miglioramento dell’interfaccia fra le sfere di alginato/idrossiapatite e il tessuto osseo. Questo è stato possibile immobilizzando sulla superficie delle sfere dei peptidi contenti la sequenza RGD e assicurandone il gusto orientamento ed un’alta resa di immobilizzazione. Dopo aver testato diverse strategie chimiche, l’immobilizzazione effettuata sfruttando la formazione di un ponte disolfuro fra ChitLac preventivamente modificato con gruppi tiolici e un peptide contenente un residuo di cisteina, è stata valutata come la miglior strategia in termini di resa di reazione; allo stesso tempo le microsfere funzionalizzate in questo modo hanno dimostrato un’alta capacità di promuovere l’adesione e la crescita di osteoblasti in esperimenti effettuati in vitro. Un altro importante tema ha riguardato l’incorporazione di un frammento della proteina BMP-2 nel costrutto al fine di promuovere il differenziamento e quindi la proliferazione cellulare. La sequenza temporale degli eventi fisiologici, ha suggerito lo sviluppo di un sistema che risulta essere la somma di due diverse strategie di rilascio: la prima caratterizzata dal semplice intrappolamento del peptide in un sistema di sfere di alginato capace di un rilascio veloce, ed il secondo caratterizzato da un rilascio lento e costante ottenuto grazie all’azione idrolitica di esterasi. Questo è stato possibile inserendo un legame enzimaticamente idrolizzabile nella struttura contenente il frammento di BMP. Questa seconda strategia ha sfruttato una chimica altamente selettiva quale la “click chemistry”. La sintesi della molecola spaziatrice recante un legame enzimaticamente idrolizzabile è stata effettuata partendo da un γ-valerolattone. Questo spaziatore è stato inoltre progettato per recare un gruppo terminale funzionale adeguato per le reazioni di click chemistry ed è stato legato al ChitLac. La reazione di cicloaddizone è stata poi effettuata fra il ChitLac funzionalizzato con lo spaziatore e il frammento di BMP anch’esso opportunamente funzionalizzato. L’idrolisi enzimatica è stata verificata, inoltre è stata eseguita un’esaustiva caratterizzazione tramite NMR ed elettroforesi capillare. E’ stata poi presa in considerazione l’incorporazione di peptidi antimicrobici nel costrutto. Partendo da dati di dicroismo circolare riguardanti l’influenza che alcuni polisaccaridi hanno sulla conformazione del peptide LL-37 in soluzione, è stata riconosciuta alla miscela LL- 37/alginato la capacità di modulare la citotossicità del peptide. La miscela ha inoltre dimostrato la capacità di mantenere l’attività antimicrobica su batteri Gram negativi e questo ci ha spinto a considerarne l’applicazione su costrutti solidi con finalità ortopediche. In quest’ambito è stato escluso, da esperimenti in vitro, un effetto causato dal semplice contatto fra cellule o batteri e una superficie di alginato caricato col peptide. L’unico possibile meccanismo di rilascio riscontrato in un costrutto di alginato/LL-37 è stato tramite la degradazione di questo. Infine, il costrutto è stato assemblato incorporando le microsfere disidratate in una soluzione concentrata di acido ialuronico, ottenendo un costrutto dall’aspetto simile ad una pasta che è in grado di facilitare il processo di iniezione del riempitivo. Misure di tipo reologico hanno indicato in incremento della componente viscoelastica aggiungendo il particolato nella soluzione di acido ialuronico, questo generalmente è associato ad una buona capacità di recuperare l’elasticità dopo l’iniezione il che è un requisito richiesto ai biomateriali usati come riempitivi ossei. I risultati ottenuti hanno dimostrato l’applicabilità del composito come sostituto osseo dotato di proprietà bioattivite (osteoconduzione, osteoinduzione, bioadesività ed effetto antimicrobico su ceppi di tipo Gram negativo).
Bone regenerative medicine is considered a potential therapeutic option for the healing of damaged bone tissue. A variety of synthetic bone graft substitutes have been investigated as alternative to current tissue based bone graft materials. In this study efforts have been made to achieve an injectable material to fill bone defects. We have designed composite injectable filler by using polysaccharides as biodegradable materials, and by functionalizing them with bioactive elements such as adhesion mediators, osteoinductive growth factors and anti-microbial peptides. The final construct is represented by a two-phase composite, whose parts have been initially built separately. The structure was thought as composed by bioactive alginate/hydroxyapatite dried microbeads functionalized with peptides, suspended in a concentrate hyaluronic acid solution as the matrix vehicle. With the aim to obtain bioactive alginate/HAp beads, different techniques of peptides-polysaccharides conjugation were considered and different peptide delivery systems were explored. In detail the peptides considered were three, the RGD active sequence with bioadhesive properties, a fragment of BMP-2 (bone morphogenetic protein-2) that promotes the differentiation of MSCs into osteoblasts, and LL-37 a human antimicrobial peptide. In order to obtain a construct with bioadhesive properties, efforts have been made to improve the tissue-alginate/HAp beads interface by immobilizing RGD peptide sequence in a manner that assure the right motif orientation and high yields. After having tested various chemical strategies, the immobilization by disulfide bridge formation between a ChitLac previously modified with a thiol group and a peptide containing a cysteine residue was evaluated to be the best in terms of yield; at the same time μbeads functionalized in that way exhibit a very high osteoblast adhesion and growth promotion in in vitro experiments. Another important topic regarded the incorporation of BMP-2 epitope fragment into the construct, to enhance differentiation and proliferation. Time-tuned physiological functionality suggested the development of a system being the sum of two delivery strategies: the first characterized by simple entrapment in alginate beads for a fast burst release and the second one giving a slow and constant release, obtained by the action of bone esterases on an enzymatically cleavable linker. This second strategy exploited a high selective chemistry such as that of click reactions. Starting by a γ-valerolactone the synthesis of the enzymatically cleavable spacer was performed. The linker was designed to contain a final functional group for click chemistry. It was bound to ChitLac and then to a modified BMP fragment by a click reaction. Enzymatic cleavage was verified and an exhaustively characterization by means of NMR and capillary electrophoresis was performed. The incorporation of antimicrobial peptides was also taken into account. Starting from the information gained by circular dichroism data on the influence on LL-37 conformation given by several polysaccharides, an optimal modulation activity of the cytotoxic effect of LL-37 was found using the peptide/alginate mixture. The demonstrated maintenance of antimicrobial activity on Gram negative strains drove to an application on solid constructs for orthopaedic applications. An effect caused by the simple contact between cells or bacteria and alginate surface loaded with the peptide, was excluded by in vitro experiments. The only possible release mechanism that an LL-37/alginate construct was able to show was related to the degradation of this one. Finally, the whole construct was assembled by incorporating the dried microbeads in a concentrate hyaluronic acid solution, obtaining a paste-like construct that can facilitate the injectability of the particulate. Rheological measurements indicated an increment of the viscoelastic component by adding particulate into hyaluronate solution; this, generally, is associated to a good capacity to regain the elasticity after the injection, as expected for a biomaterial for bone filler applications. The results collected demonstrate the applicability of the obtained composite as bone graft substitute with bioactive properties (osteoinduction, osteoconduction, bioadhesivity and antibiotic effect on Gram negative strains).
XXII Ciclo
1978
Wu, Chang-Chin, and 吳長晉. "Studies of Biodegradable and Injectable Composite Bone Filler Based on Polymer and Calcium Phosphate Ceramic Powder." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/34079403450001576514.
Повний текст джерела國立臺灣大學
醫學工程學研究所
100
While many different filler materials have been applied in vertebral augmentation procedures, none is perfect in all biomechanical and biological characteristics. To minimize possible shortages, we synthesized a new biodegradable, injectable and premixed composite made from poly(propylene fumarate) (PPF) and biphasic α-tricalcium phosphate (α-TCP)/hydroxyapatite (HAP) ceramics powder and evaluated the material properties of the compound in vitro. We mixed the PPF cross-linked by N-Vinyl pyrrolidinone and biphasic α-TCP/HAP powder in different ratios with benzoyl peroxide as an initiator. The setting time and temperature were recorded, although they could be manipulated by differing the concentrations of hydroquinone and N-N-Dimethyl-p-Toluidine. Degradation, cytocompatibility, mechanical properties, and radio-opacity were analyzed after the composites were cured by a cylindrical shape. We also compared the study materials with polymethyl methacrylate (PMMA) and PPF with pure HAP particles. Results showed lower temperature during curing process (38-44oC), sufficient initial mechanical compression fracture strength (61.1±3.7MPa), and gradual degradation were observed in the newly developed bone filler. Radio-opacity in Hounsfield units was similar to PMMA as determined by computed tomography scan. Both pH value variation and cytotoxicity were within biological tolerable limits based on the biocompatibility tests. Mixtures with 70% α-TCP/HAP powder were superior to other groups and were applied in vivo study. To evaluate these cements in vivo, a porcine vertebral model was applied. Besides the before-mentioned 70% α-TCP/HAP/PPF mixture, 70% TtCP/DCP/PPF composite was also recruited in vivo for commercial availability and similar biphasic transformation properties after hydration to compare these two biodegradable cements with PMMA. Twelve miniature pigs had been enrolled in this study. Four cylindrical holes were drilled at the center of lateral cortex of vertebral bodies of lumbar spine with 5mm in diameter and 10mm in length through lateral retroperitoneal approach. The premixed cements were injected into the holes randomly and hardened in situ with setting time and highest setting temperature recorded. After 3months and 6months, the pigs were sacrificed. The retrieved spines specimens were scanned with X-ray and computed tomography. Samples were prepared for histological studies with/without de-calcification. The different appearances of solidified cements and the interaction zones between cement and bone were analyzed and compared. Setting temperatures of PMMA were significantly higher than composite groups. There were two leakages of cement in spinal canals without significant neurological complication. The differences were difficult to be identified by plain X-ray films and CT scans provided better resolutions for morphologic comparisons, volumetric measurement and quantified radiopacity among groups. Little volume, morphology and Hounsfield unit variation of PMMA is detected between 3 months’ and 6 months’ groups and implies inert nature of PMMA cement. Only 2 of 12 PMMA blocks were surrounded by radiolucent lines, and those lines were fibrous tissues in histology. While the remainder without radio-lucent lines were direct bone-PMMA contact. In contrast, irregular sclerotic ring along the cement blocks, significant decreases of cement volume and morphologic changes showed the degradability of both composite cements, despite the decreases of HU were not significant. More cement block laminations, radiolucent halos and vertebral deformities were observed in TtCP/DCP group, and this implied better degradability with obvious influences on surrounding host tissues by released products. Regarding control groups, the defects shrunk significantly with significant increase in Hounsfield units and this indicates good bone healing property of young porcine individuals. New bone formation with substitution of cement were observed in histological specimens of both composite cements groups, but we are unable to quantify the differences between groups for sampling divergences, processing losses, staining errors and observer’s biases. Besides new bone formation and remodeling along outer surfaces of some composites blocks, however in some other blocks, abundant fibrous tissues surrounding, or even invading into blocks, was also observed in some vertebra. Radiological and histological changes were observed in all composite groups and these modifications were along diminished block boundaries. These suggested gradual substitution of decomposed composite by new bone formation, which could not be inspected around PMMA block. In non-decalcified histology, results of PMMA group were more reliable but neither new bone formation nor composite substitution was identified along the PMMA blocks. When combining the results of gross, histological and radiographic finding, each radiologic finding corresponding to a specific histological illustration, such as radio-lucent line indicating histological fibrous tissue and sclerotic rings representing new bone formation with remodeling. Even though it is unable to make histological slices identical completely to CT scan slices, CT scanning could be a preliminary and easy way for evaluation of injectable bone cements in vertebral bodies. This study indicated that these composites of PPF and biphasic CPCs powder are promising, premixed, injectable biodegradable bone fillers for these two composites possessing characteristics better than PMMA’s, but there are still some improvements should be done to increase reliability of the composite in the future.
Частини книг з теми "Injectable bone filler"
Wang, Jian Sheng, K. E. Tanner, Saba Abdulghani, and Lars Lidgren. "Indentation Testing of a Bone Defect Filled with Two Different Injectable Bone Substitutes." In Bioceramics 17, 89–92. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-961-x.89.
Повний текст джерела