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Статті в журналах з теми "Infertility, Male Environmental aspects"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 31 січня 2023

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1

Puzuka, Agrita, Baiba Alksere, Linda Gailite, and Juris Erenpreiss. "Idiopathic Infertility as a Feature of Genome Instability." Life 11, no. 7 (June 29, 2021): 628. http://dx.doi.org/10.3390/life11070628.

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Genome instability may play a role in severe cases of male infertility, with disrupted spermatogenesis being just one manifestation of decreased general health and increased morbidity. Here, we review the data on the association of male infertility with genetic, epigenetic, and environmental alterations, the causes and consequences, and the methods for assessment of genome instability. Male infertility research has provided evidence that spermatogenic defects are often not limited to testicular dysfunction. An increased incidence of urogenital disorders and several types of cancer, as well as overall reduced health (manifested by decreased life expectancy and increased morbidity) have been reported in infertile men. The pathophysiological link between decreased life expectancy and male infertility supports the notion of male infertility being a systemic rather than an isolated condition. It is driven by the accumulation of DNA strand breaks and premature cellular senescence. We have presented extensive data supporting the notion that genome instability can lead to severe male infertility termed “idiopathic oligo-astheno-teratozoospermia.” We have detailed that genome instability in men with oligo-astheno-teratozoospermia (OAT) might depend on several genetic and epigenetic factors such as chromosomal heterogeneity, aneuploidy, micronucleation, dynamic mutations, RT, PIWI/piRNA regulatory pathway, pathogenic allelic variants in repair system genes, DNA methylation, environmental aspects, and lifestyle factors.

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2

Baszyński, Jędrzej, Piotr Kamiński, Maria Bogdzińska, Sławomir Mroczkowski, Marek Szymański, Karolina Wasilow, Emilia Stanek, et al. "Enzymatic Antioxidant Defense and Polymorphic Changes in Male Infertility." Antioxidants 11, no. 5 (April 22, 2022): 817. http://dx.doi.org/10.3390/antiox11050817.

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The intensification of oxidative stress and destabilization of the antioxidative defenses of an organism is a consequence of many environmental factors. We considered aspects conditioning male reproductive potential and the functionality of enzymatic antioxidative mechanisms, i.e., superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), and their correlations with Li, Be, B, Na, Mg, Al, P, K, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Sr, Mo, Ag, Cd, Sn, Sb, Ba, Hg, Tl, Pb, and malondialdehyde (MDA), as well as genetic polymorphism IL-4v.C589T (rs2243250) in men with infertility (n = 76). A healthy normozoospermic control (n = 87) was also used. We assessed the impact of negative changes driven by oxidative stress on enzymatic antioxidative mechanisms as well as the role of MDA in the overall process. On this basis, we infer connections between disturbances in enzymatic antioxidative defense and reproductive potential. Based on a molecular analysis of the polymorphism of gene IL-4v.C589T (rs2243250) (chromosome 5) (PCR-RFLP), we considered the relationships among particular genotypes with the possibility of occurrence of male infertility. Concentrations of chemical elements were measured in the blood. The activity of antioxidants and MDA levels were measured in serum. In the infertile group, higher GPx activity was noted (6.56 nmoL·min−1·mL−1, control: 4.31 nmoL·min−1·mL−1; p = 0.004), while GR achieved a greater level in the control (17.74 nmoL·min−1·mL−1, infertile: 15.97 nmoL·min−1·mL−1, p = 0.043), which implies diversified efficiency of the first and second lines of defense. The polymorphism of IL-4v.C589T (rs2243250) was not directly connected with infertility because there were not any differences in the frequency of genotypes between the infertile and control group (p = 0.578). An analysis of genotypes CC and TT (polymorphism IL-4v.C589T (rs2243250) indicated numerous correlations between antioxidants, chemical elements and MDA. Therefore, chemical economy, antioxidative defense and genetic conditions are connected and jointly shape male reproductive potential. Chemical elements influence antioxidative defense and male fertility; the most important modulators appeared to be Na, Ba, Al and B. The polymorphism of gene IL-4v.C589T (rs2243250) has a limited influence on antioxidative defense and the metabolism of chemical elements.

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3

Leshchenko, O. Ya, E. V. Genich, M. A. Darenskaya, and L. I. Kolesnikova. "HIV and infertility: neuro-endocrine and metabolic aspects." HIV Infection and Immunosuppressive Disorders 12, no. 4 (February 9, 2021): 73–80. http://dx.doi.org/10.22328/2077-9828-2020-12-4-73-80.

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Objective: to establish a correlation of the main neuroendocrine and metabolic parameters associated with infertility and to provide a prognostic assessment of reproductive disorders in HIV-infected women, stages 4.Materials and methods. Cross-sectional, cohort, clinical and sociological study of fertility of 83 women of reproductive age with HIV, stages 4.Results. The most signiﬁcant indicators of lipid peroxidation and neuroendocrine regulation systems have been established in patients with HIV infection and reproductive disorders, which will make it possible to predict these disorders in the future. Decreased ovarian reserve, ovarian steroid function, increased pituitary prolactinergic function are associated with a deﬁciency of a number of antioxidants (retinol, tocopherol, superoxide dismutase) and the development of oxidative stress with a predominant accumulation of intermediate lipid peroxidation products in HIV-infected women with infertility.Conclusion. The pathogenetically substantiated principle of the correction of antioxidant status is the use of a-tocopherol and retinol preparations and the correction of hormonal levels in HIV-infected women with reproductive disorders.

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4

Coccia, Maria Elisabetta, Luca Nardone, and Francesca Rizzello. "Endometriosis and Infertility: A Long-Life Approach to Preserve Reproductive Integrity." International Journal of Environmental Research and Public Health 19, no. 10 (May 19, 2022): 6162. http://dx.doi.org/10.3390/ijerph19106162.

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Laparoscopic surgery was originally considered the gold standard in the treatment of endometriosis-related infertility. Assisted reproductive technology (ART) was indicated as second-line treatment or in the case of male factor. The combined approach of surgery followed by ART proved to offer higher chances of pregnancy in infertile women with endometriosis. However, it was highlighted how pelvic surgery for endometriosis, especially in cases of ovarian endometriomas, could cause iatrogenic damage due to ovarian reserve loss, adhesion formation (scarring), and ischemic damage. Furthermore, in the last few years, the trend to delay the first childbirth, recent technological advances in ultrasound diagnosis, and technological progress in clinical and laboratory aspects of ART have certainly influenced the approach to infertility and endometriosis with, ART assuming a more relevant role. Management of endometriosis should take into account that the disease is chronic and involves the reproductive system. Consequently, treatment and counselling should aim to preserve the chances of pregnancy for the patient, even if it is not associated with infertility. This review will analyse the evolution of the management of infertility associated with endometriosis and propose an algorithm for treatment decision-making based on the most recent acquisitions.

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5

Medenica, Sanja, Dusan Zivanovic, Ljubica Batkoska, Susanna Marinelli, Giuseppe Basile, Antonio Perino, Gaspare Cucinella, Giuseppe Gullo, and Simona Zaami. "The Future Is Coming: Artificial Intelligence in the Treatment of Infertility Could Improve Assisted Reproduction Outcomes—The Value of Regulatory Frameworks." Diagnostics 12, no. 12 (November 28, 2022): 2979. http://dx.doi.org/10.3390/diagnostics12122979.

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Анотація:

Infertility is a global health issue affecting women and men of reproductive age with increasing incidence worldwide, in part due to greater awareness and better diagnosis. Assisted reproduction technologies (ART) are considered the ultimate step in the treatment of infertility. Recently, artificial intelligence (AI) has been progressively used in the many fields of medicine, integrating knowledge and computer science through machine learning algorithms. AI has the potential to improve infertility diagnosis and ART outcomes estimated as pregnancy and/or live birth rate, especially with recurrent ART failure. A broad-ranging review has been conducted, focusing on clinical AI applications up until September 2022, which could be estimated in terms of possible applications, such as ultrasound monitoring of folliculogenesis, endometrial receptivity, embryo selection based on quality and viability, and prediction of post implantation embryo development, in order to eliminate potential contributing risk factors. Oocyte morphology assessment is highly relevant in terms of successful fertilization rate, as well as during oocyte freezing for fertility preservation, and substantially valuable in oocyte donation cycles. AI has great implications in the assessment of male infertility, with computerised semen analysis systems already in use and a broad spectrum of possible AI-based applications in environmental and lifestyle evaluation to predict semen quality. In addition, considerable progress has been made in terms of harnessing AI in cases of idiopathic infertility, to improve the stratification of infertile/fertile couples based on their biological and clinical signatures. With AI as a very powerful tool of the future, our review is meant to summarise current AI applications and investigations in contemporary reproduction medicine, mainly focusing on the nonsurgical aspects of it; in addition, the authors have briefly explored the frames of reference and guiding principles for the definition and implementation of legal, regulatory, and ethical standards for AI in healthcare.

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6

Akhtar, Shamim, Rizwana Nasreen, Humaira Bibi, Ayesha Azhar Khan, Asma Amin Baig, and Najia Riffat. "Reproductive Features of Patients with Secondary Infertility." Pakistan Journal of Medical and Health Sciences 16, no. 10 (October 30, 2022): 111–12. http://dx.doi.org/10.53350/pjmhs221610111.

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Background: Childlessness is a very pain full situation. It affects both partners but more to females. Burden of secondary infertility is more than primary infertility but it is not captured properly. Secondary infertility also has significant psychological, personal and marital sufferings. Social pressures add the anxiety if only daughters are born. Aim: To find out the reproductive characteristic features of patients presenting with secondary infertility. Place and duration: This retrospective cross sectional study was conducted in Health Care Center Hospital (Pvt) Ltd from July 2021 to September 2022. Method: All patients with secondary infertility of more than one year were included who had previous one or more spontaneous conceptions irrespective of pregnancy outcome. Patients who had no record of previous pregnancies and those who conceived after infertility treatment were excluded. Clinical history was checked from patient’s files and delivery registers. Data was entered in preformed Performa and analyzed by SPSS Version 20. Frequencies were calculated by percentages. Results: Total 115 patients with secondary infertility were included. Sixty one patients had one or more parity, 54 patients had miscarriages. Fifty eight patients had alive babies and 3 babies died. Among 58 live babies 40 patients had only females, 12 had only male and 6 had both male and female children. Among 61 para women, forty three patients had vaginal delivery, 33 normal vaginal and 10 were instrumental deliveries. Cesarean Section was done in 18 patients, 13 were emergency and 05 elective C/S. Practical implication This study will help to understand the burden and factors contributing to secondary infertility. This will guide to manage those factors so that to lesson the secondary infertility. Conclusion: Secondary infertility is an important issue in gynaecological clinics. These patients usually have some identifiable risk factors. Their case should be reviewed carefully to find out the risk factors for proper management. Keywords: Infertility, tubal factor, STDs, miscarriage, Cesarean section,

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7

Zańko, Adrianna, Katarzyna Siewko, Adam Jacek Krętowski, and Robert Milewski. "Lifestyle, Insulin Resistance and Semen Quality as Co-Dependent Factors of Male Infertility." International Journal of Environmental Research and Public Health 20, no. 1 (December 30, 2022): 732. http://dx.doi.org/10.3390/ijerph20010732.

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Infertility is a problem that affects millions of couples around the world. It is known as a disease of couples, not individuals, which makes diagnosis difficult and treatment unclear. Male infertility can have many causes, from mechanical ones to abnormal spermatogenesis or spermiogenesis. Semen quality is determined by a number of factors, including those dependent on men themselves, with the number of infertile men growing every year. These include, e.g., diet, physical activity, sleep quality, stress, among many others. As these factors co-exist with insulin resistance, which is a disease closely related to lifestyle, it has been singled out in the study due to its role in affecting semen quality. In order to examine connections between lifestyle, insulin resistance, and semen quality, a review of literature published from 1989 to 2020 in the following databases PubMed/Medline, EMBASE (Elsevier), Scopus, Web of Science, and Google Scholar was performed. Hence, semen quality, environment, and insulin resistance are interrelated, thus it is difficult to indicate which aspect is the cause and which is the effect in a particular relationship and the nature of possible correlations. Since the influence of lifestyle on semen quality has been extensively studied, it is recommended that more thorough research be done on the relationship between insulin resistance and semen quality, comparing the semen quality of men with and without insulin resistance.

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8

Hall, Julie M., and Callie W. Greco. "Perturbation of Nuclear Hormone Receptors by Endocrine Disrupting Chemicals: Mechanisms and Pathological Consequences of Exposure." Cells 9, no. 1 (December 19, 2019): 13. http://dx.doi.org/10.3390/cells9010013.

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Much of the early work on Nuclear Hormone Receptors (NHRs) focused on their essential roles as mediators of sex steroid hormone signaling in reproductive development and function, and thyroid hormone-dependent formation of the central nervous system. However, as NHRs display tissue-specific distributions and activities, it is not surprising that they are involved and vital in numerous aspects of human development and essential for homeostasis of all organ systems. Much attention has recently been focused on the role of NHRs in energy balance, metabolism, and lipid homeostasis. Dysregulation of NHR function has been implicated in numerous pathologies including cancers, metabolic obesity and syndrome, Type II diabetes mellitus, cardiovascular disease, hyperlipidemia, male and female infertility and other reproductive disorders. This review will discuss the dysregulation of NHR function by environmental endocrine disrupting chemicals (EDCs), and the associated pathological consequences of exposure in numerous tissues and organ systems, as revealed by experimental, clinical, and epidemiological studies.

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9

Lyaginskaya, Antonina M., I. M. Petoyan, A. P. Ermalitskiy, V. V. Kuptsov, and N. M. Karelina. "RADIATION-HYGIENIC ASPECTS OF REPRODUCTIVE HEALTH IN MALES OF THE STAFF OF THE NUCLEAR POWER PLANT." Hygiene and sanitation 96, no. 9 (March 27, 2019): 883–87. http://dx.doi.org/10.18821/0016-9900-2017-96-9-883-887.

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The aim of this study was a retrospective evaluation of the reproductive health of the male staff of the Kalinin and Kursk nuclear power plant (NPP). Material and Methods. Fertility indices were used for the evaluation of the reproductive health status (ability to have children) and the health status of their offspring. For the assessment of the fertility there were used data concerning the marital status, childbirths and radiation doses received by males, obtained from the questionnaires, developed as part of this study. The data about the health of newborns was obtained from information copied from the individual cards of pregnant history cases and infant history case. In total, in the study there was analyzed data on the marital status of 679 men from Kalinin and 631 men from Kursk NPP, as well as data on the 735 and 813 newborn in the families of staff of the Kalinin and Kursk NPP, and data on 1438 and 1284 pregnant women respectively. As control groups there were used data about health of newborns and pregnant women of cities of Udomlya and Kurchatov. The combined groups included 1549 newborns and of 2718 pregnant women. Results. Infertile marriages due to the male infertility accounted for 7.3% of the Kalinin NPP personnel, and 2.5% -of Kursk NPP personnel. The incidence and complication rates of the pregnancy in families of Kalinin and Kursk NPP staff are comparable with those in the control group of pregnant women and were 75.7%, 61.6% and 71.0%, respectively. Adverse pregnancy outcomes (spontaneous abortions and early neonatal death of the newborn) were recorded in 6.9%, 0.1% in the families of the personnel of the Kalinin NPP and 8.9%, 0.2% in the families of the personnel Kursk of the NPP complying with the control values of 7.6% 0.2%, respectively. The frequency of the birth of the health child corresponds to control values as 73.6% of the families of the personnel of the Kalinin NPP, amounting to 65.3% in the families of the personnel of the Kursk NPP and 69.7% in the control group. The relative risk of birth of a child with congenital malformations RR = 0,84 in the families of staff at Kalinin NPP and RR = 1.0 - at Kursk NPP. Conclusion. No impact of occupational exposure on the reproductive health was revealed for the male staff both at Kalinin and Kursk NPP.

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10

Borovkova, Violetta V., Aleksandr V. Zubko, Tamara P. Sabgayda, Konstantin E. Khomanov, and Gleb S. Krasnov. "The opinion of the medical community on the legal issues of surrogate maternity." HEALTH CARE OF THE RUSSIAN FEDERATION 66, no. 1 (March 4, 2022): 76–84. http://dx.doi.org/10.47470/0044-197x-2022-66-1-76-84.

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Introduction. Surrogacy is a method of infertility treatment involving the conclusion of an agreement between potential parents, a surrogate mother and a medical institution. Until now, lawyers have not been able to develop a unified approach to forming the regulatory framework for surrogacy. Whether healthcare providers have developed a standard view of this problem is not clear. The purpose is to summarise the medical community representatives’ views on the surrogacy program’s managing issues and their participants’ rights and obligations. Material and methods. The Internet survey was conducted among medical workers of various specialisations from different regions of Russia and among future specialists (students of medical universities and interns). 7504 questionnaire was analysed. The questions concerned the indications for surrogate motherhood, the sources of its funding, the citizenship of the participants in surrogacy and their contractual obligations, the rights of the surrogate mother and the ordering parents. Results. medical specialists assign a pivotal role to the surrogacy program’s legal aspects, despite being implemented using high-tech medical technologies. They give priority rights to a newborn child to the ordering parents. During pregnancy and childbirth, decisions regarding lifestyle, hospitalisation, and delivery methods should be made only in conjunction with specialists from the medical institution that signed the contract. As the level of professional responsibility of medical specialists grows, the share of answers about the inadmissibility of state funding of surrogacy, the implementation of surrogacy programs for foreign citizens and single men and women as genetic donors increases, and the share of answers about the admissibility of altruistic surrogacy decrease. Conclusion. Having decided on the legal issues of managing medical care in surrogacy programs, representatives of the medical community do not consider this type of high-tech medical care a common way to solve the problem of infertility, considering it as an exclusive method of medical care for married couples with infertility of women.

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11

Druzhinina, N. K., and E. А. Korovyakova. "MALE INFERTILITY. GENETIC ASPECTS." Bulletin "Biomedicine and sociology" 3, no. 4 (December 30, 2018): 49–51. http://dx.doi.org/10.26787/nydha-2618-8783-2018-3-4-49-51.

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12

Pizzol, Damiano, Alessandro Bertoldo, and Carlo Foresta. "Male infertility: biomolecular aspects." Biomolecular Concepts 5, no. 6 (December 1, 2014): 449–56. http://dx.doi.org/10.1515/bmc-2014-0031.

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AbstractMale infertility is a problem that faces increasing interest, and the continuous development of assisted reproduction techniques solicits attempts to identify a precise diagnosis, in particular for idiopathic infertile couples and those undergoing assisted reproductive technique cycles. To date, diagnosis of male infertility is commonly based on standard semen analysis, but in many cases, this is not enough to detect any sperm abnormality. A better understanding of biomolecular issues and mechanism of damaged spermatogenesis and the refinement of the molecular techniques for sperm evaluation and selection are important advances that can lead to the optimization of diagnostic and therapeutic management of male and couple infertility. Faced with a growing number of new proposed techniques and diagnostic tests, it is fundamental to know which tests are already routinely used in the clinical practice and those that are likely to be used in the near future. This review focuses on the main molecular diagnostic techniques for male infertility and on newly developed methods that will probably be part of routine sperm analysis in the near future.

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13

Burnett, Arthur L., Natalie C. Edwards, Tonya M. Barrett, Krista D. Nitschelm, and Samir K. Bhattacharyya. "Addressing Health-Care System Inequities in the Management of Erectile Dysfunction: A Call to Action." American Journal of Men's Health 14, no. 5 (September 2020): 155798832096507. http://dx.doi.org/10.1177/1557988320965078.

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Erectile dysfunction (ED) is a common, burdensome, and costly urologic condition strongly related to all aspects of general health, from physical to mental. ED has profound consequences as it may interfere physical well-being, quality of life (QoL), self-esteem, relationships, self-worth, and productivity. It is therefore important to ensure that all types of effective ED treatments are consistently accessible to patients. While federal and state mandates ensure access to treatment for women’s breast health, female-factor infertility, and gender affirmation to ensure that these individuals do not experience a diminished QoL, there are no comparable mandates for men’s sexual and reproductive health. The burden of ED necessitates a call to action to improve the accessibility of ED treatments. The call to action steps include: (a) coverage for pharmacological, surgical, and other ED treatments should be viewed in the same way as coverage for other health issues, whether male or female and regardless of the stages of treatment, physical dysfunction, or physical changes; (b) American Urological Association (AUA) guidelines for the management of ED should be followed, including implementation of templates in electronic medical records (EMRs) to support adherence to the guidelines; and (c) coverage criteria should explicitly state that the criteria are intended to support gender equity for sexual and reproductive health care and should not be used to prevent men from receiving medically necessary ED treatments. This call to action offers a pathway to support every man who seeks treatment for ED as a medically necessary intervention by removing systemic health-care barriers.

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14

Velu, Arunadevi, and Geetha Prasad. "Epidemiologic aspects of male infertility." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 8 (July 26, 2017): 3362. http://dx.doi.org/10.18203/2320-1770.ijrcog20173446.

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Background: Infertility affects 10-15% of couples worldwide with rates steadily increasing in the Industrialized world, in part due to the deterioration of male reproductive health.Methods: This study was performed in an attempt to clarify the associated factors that might play a role in group of Indian infertile men. This study was a cross – sectional descriptive study conducted in Karpaga Vinayaga Institute of Medical Sciences. The information was obtained from the men who had attended the clinic from January 2016-January 2017. The factors that were studied in this research are the demographic characteristics, alcohol consumption, smoking, exposure to heavy metals, obesity, stress and history of surgery.Results: In 31.6% of couples, the cause of infertility was pure male factor and in 20.4% of them the problem was related to male and female factor both. The most important associated factors for male factor included history of varicocele operation (24%), alcohol consumption (18%) and cigarette smoking (16%).Conclusions: Male factors play a significant role in up to 50 percent of infertility cases, stressing the need for a logical, stepwise approach to the evaluation of the male partner.

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15

Witczak, Bartosz, Justyna E. Klusek, and Jolanta Klusek. "Genetic aspects of male infertility." Medical Studies 4 (2014): 276–79. http://dx.doi.org/10.5114/ms.2014.47928.

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16

Pasqualotto, Fábio Firmbach, Cristhiany Victor Locambo, Kelly Silveira Athayde, and Sami Arap. "Measuring male infertility: epidemiological aspects." Revista do Hospital das Clínicas 58, no. 3 (2003): 173–78. http://dx.doi.org/10.1590/s0041-87812003000300008.

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Evidence suggests that human semen quality may have been deteriorating in recent years. Most of the evidence is retrospective, based on analysis of data sets collected for other purposes. Measures of male infertility are needed if we want to monitor the biological capacity for males to reproduce over time or between different populations. We also need these measures in analytical epidemiology if we want to identify risk indicators, risk factors, or even causes of an impaired male fecundity-that is, the male component in the biological ability to reproduce. The most direct evaluation of fecundity is to measure the time it takes to conceive. Since the time of conception may be missed in the case of an early abortion, time to get pregnant is often measured as the time it takes to obtain a conception that survives until a clinically recognized pregnancy or even a pregnancy that ends with a live born child occurs. A prolonged time required to produce pregnancy may therefore be due to a failure to conceive or a failure to maintain a pregnancy until clinical recognition. Studies that focus on quantitative changes in fecundity (that does not cause sterility) should in principle be possible in a pregnancy sample. The most important limitation in fertility studies is that the design requires equal persistency in trying to become pregnant and rather similar fertility desires and family planning methods in the groups to be compared. This design is probably achievable in exposure studies that make comparisons with reasonable comparable groups concerning social conditions and use of contraceptive methods.

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17

Kedem, Peri, Mario Mikulincer, Yvonne E. Nathanson, and Benjamin Bartoov. "Psychological aspects of male infertility." British Journal of Medical Psychology 63, no. 1 (March 1990): 73–80. http://dx.doi.org/10.1111/j.2044-8341.1990.tb02858.x.

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18

McLaughlin, Kevin, and J. White. "Surgical Aspects of Male Infertility." Seminars in Reproductive Medicine 9, no. 02 (May 1991): 156–61. http://dx.doi.org/10.1055/s-2007-1019405.

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19

Akopova, R. A., and T. V. Kokoreva. "ENDOCRINE ASPECTS OF MALE INFERTILITY." Bulletin "Biomedicine and sociology" 3, no. 4 (December 30, 2018): 17–19. http://dx.doi.org/10.26787/nydha-2618-8783-2018-3-4-17-19.

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20

Namiki, Mikio. "Genetic Aspects of Male Infertility." World Journal of Surgery 24, no. 10 (October 2000): 1176–79. http://dx.doi.org/10.1007/s002680010198.

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21

Kopa, Zsolt, and Ida Johnson. "Immune aspects of male infertility." Journal of Reproductive Immunology 101-102 (March 2014): 26. http://dx.doi.org/10.1016/j.jri.2013.12.091.

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22

Pichugova, S. V., J. G. Lagereva, I. V. Rybina, S. V. Belyaeva, L. G. Tulakina, and Ya B. Beykin. "Immuno-Endocrine Aspects of Male Infertility." Journal of Ural Medical Academic Science 14, no. 2 (2016): 102–25. http://dx.doi.org/10.22138/2500-0918-2016-14-2-102-125.

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23

Pavlov, V. N., E. F. Galimova, B. F. Teregulov, V. T. Kaybishev, and Sh N. Galimov. "MOLECULAR AND METABOLIC ASPECTS OF MALE INFERTILITY." Herald Urology, no. 2 (June 20, 2016): 40–59. http://dx.doi.org/10.21886/2308-6424-2016-0-2-40-59.

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24

Joja, O. D., D. Dinu, and D. Paun. "Psychological Aspects of Male Infertility. An Overview." Procedia - Social and Behavioral Sciences 187 (May 2015): 359–63. http://dx.doi.org/10.1016/j.sbspro.2015.03.067.

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25

KRAUSE, Walter. "Ralph deVere White: Aspects of Male Infertility." Andrologia 15, no. 4 (April 24, 2009): 373. http://dx.doi.org/10.1111/j.1439-0272.1983.tb00155.x.

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26

Gil'manov, A. A., G. Z. Akhmetzyanova, A. N. Khisamutdinov, S. R. Shakirzyanova, and K. R. Shakirzyanova. "Social aspects of prevention of male and female infertility." Kazan medical journal 100, no. 6 (December 9, 2019): 970–74. http://dx.doi.org/10.17816/kmj2019-970.

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Анотація:

Aim. To evaluate the degree of awareness of the managable social risk factors for prevention of male and female infertility and to suggest preventive measures. Methods. We conducted a survey among 140 medical students and 140 students of other higher educational institutions. The majority of students in both groups who participated in the survey were aged 21 to 23 years (60%). There were 20 questions in the questionnaire. They were of the following type: Do you know that ... can lead to infertility? Instead of the dots there were certain risk factors. Students answered the question yes or no. Results. According to the results of the survey, medical students are much better aware of risk factors of infertility and its prevention. Most of the medical students and students of other institutions (72 and 73% respectively) plan to be parents already at the age of 23 to 28 which is in the upcoming decade so they have to think about infertility prevention now. Conclusion. Awareness of infertility risk factors especially among non-medical students is quite low so spreading the information about prevention of the diseases leading to infertility among youth is necessary.

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Perheentupa, Antti. "Male infertility and environmental factors." Global Reproductive Health 4, no. 2 (2019): e28. http://dx.doi.org/10.1097/grh.0000000000000028.

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Gracia, C. R., M. D. Sammel, C. Coutifaris, D. S. Guzick, and K. T. Barnhart. "Environmental exposures and male infertility." Fertility and Sterility 82 (September 2004): S177. http://dx.doi.org/10.1016/j.fertnstert.2004.07.463.

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29

Sharpe, R. M. "Environmental estrogens and male infertility." Pure and Applied Chemistry 70, no. 9 (September 1, 1998): 1685–701. http://dx.doi.org/10.1351/pac199870091685.

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30

Byun, J., C. W. Bak, J. H. Lee, Y. J. Ju, S. Han, H. H. Seok, S. W. Lyu, et al. "SESSION 33: MALE INFERTILITY - CLINICAL AND LABORATORY ASPECTS." Human Reproduction 27, suppl 2 (January 1, 2012): ii47—ii49. http://dx.doi.org/10.1093/humrep/27.s2.32.

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31

Boiko, O. V., A. A. Nikolaev, and N. I. Gydinskaya. "Microbiological aspects of male infertility pathogenesis (a review)." Problemy reproduktsii 23, no. 1 (2017): 84. http://dx.doi.org/10.17116/repro201723184-89.

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32

Phelps, Jerry. "Headliners: Male Infertility." Environmental Health Perspectives 111, no. 12 (September 1, 2003): a639. http://dx.doi.org/10.1289/ehp.111-a639.

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33

Al-Omary, Hanan L., Zainab M. Alawa, and IsraaF jaafar. "Environmental Lead Exposure and Male Infertility." IOSR Journal of Dental and Medical Sciences 15, no. 09 (September 2016): 49–54. http://dx.doi.org/10.9790/0853-1509044954.

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34

Wilcox, Allen J., and Jens Peter E. Bonde. "On environmental threats to male infertility." Asian Journal of Andrology 15, no. 2 (January 21, 2013): 199–200. http://dx.doi.org/10.1038/aja.2012.153.

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35

Szkodziak, Filip, Jarosław Krzyżanowski, and Piotr Szkodziak. "Psychological aspects of infertility. A systematic review." Journal of International Medical Research 48, no. 6 (June 2020): 030006052093240. http://dx.doi.org/10.1177/0300060520932403.

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Анотація:

Objective Fertility may be defined as a capacity to conceive and produce offspring. Infertility is characterized by failure to establish a clinical pregnancy after 12 months of regular and unprotected sexual intercourse. Infertility concerns an estimated 8–12% of the global population, and is associated with factors including time of unwanted non-conception, age of female partner and number of diseases impacting fertility. Unexplained infertility is described as idiopathic. This study aimed to analyse and evaluate the influence of mental disorders, often considered as reasons for idiopathic infertility, on female and male fertility, including stress, depression, sleep and eating disorders, and addictions. Methods This systematic review comprised a search of MEDLINE, Cochrane and PubMed databases for relevant articles that were analysed by two independent reviewers. Results A total of 106 articles published between 1955–2019 were included. Mental disorders modify endocrine gland and immune system functioning at both the tissue and cellular level, and are negatively associated with female and male fertility. Conclusion Mental disorders may negatively impact female and male fertility. Further studies are required to explain the exact role and contribution of mental disorders to fertility.

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Cinar, C., C. Beyazyurek, G. Ozgon, S. Ozkan, B. Ismailoglu, O. Oner, F. Fiorentino, and S. Kahraman. "4.002 Genetic aspects of male infertility in assisted reproduction." Reproductive BioMedicine Online 16 (January 2008): s38. http://dx.doi.org/10.1016/s1472-6483(10)61385-5.

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37

Madsen, Svend Aage, Alice T. Mikkelsen, Lisbeth Ohrt, Lise Dessing, and Peter Humaidan. "Men in ICSI treatment - Psychological aspects of male infertility." Journal of Men's Health 7, no. 3 (October 2010): 300. http://dx.doi.org/10.1016/j.jomh.2010.09.062.

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38

Baluch, Bahman, Mariam Nasseri, and Malek Mansour Aghssa. "Psychological and social aspects of male infertility in a male dominated society." Journal of Social and Evolutionary Systems 21, no. 1 (January 1998): 113–20. http://dx.doi.org/10.1016/s1061-7361(99)80007-1.

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39

HOUSTON, Brendan J., and Moira K. O’BRYAN. "Genetics of Male Infertility." Fertility & Reproduction 04, no. 03n04 (September 2022): 103. http://dx.doi.org/10.1142/s2661318222740152.

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Background: Male infertility is a common condition that affects at least 7% of men in Western countries and is associated with an elevated risk of comorbidities and mortality. While genetics is predicted to play a role in a significant percentage of cases, the aetiology of male infertility remains largely unknown. In light of this, the International Male Infertility Genomics Consortium (IMIGC) was founded, with the goals of recruiting large cohorts of infertile men, use next generation sequencing to identify high-confidence genetic causes of their infertility, and validate these genetic causes using replication studies and/or animal models. A number of working groups within the IMIGC are beginning to identify several novel genetic variants causative of human male infertility, and thus, essential male fertility genes. The requirement of these poorly characterised genes for male fertility is being further tested in mice and flies, including the identification of their molecular function(s) across the discrete phases of spermatogenesis and sperm function. These studies will ultimately transform the diagnosis of male infertility from a phenotypic description to a molecular diagnosis. These findings will also allow more realistic predictions regarding the consequences of using gametes from men with genetic variants in assisted reproductive technologies, and will likely identify avenues for therapeutic intervention.

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40

Dutta, Sulagna, Pallav Sengupta, Sanghamitra Das, Petr Slama, and Shubhadeep Roychoudhury. "Reactive Nitrogen Species and Male Reproduction: Physiological and Pathological Aspects." International Journal of Molecular Sciences 23, no. 18 (September 12, 2022): 10574. http://dx.doi.org/10.3390/ijms231810574.

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Reactive nitrogen species (RNS), like reactive oxygen species (ROS), are useful for sustaining reproductive processes such as cell signaling, the regulation of hormonal biosynthesis, sperm capacitation, hyperactivation, and acrosome reaction. However, endogenous levels of RNS beyond physiological limits can impair fertility by disrupting testicular functions, reducing gonadotropin production, and compromising semen quality. Excessive RNS levels cause a variety of abnormalities in germ cells and gametes, particularly in the membranes and deoxyribonucleic acid (DNA), and severely impair the maturation and fertilization processes. Cell fragmentation and developmental blockage, usually at the two-cell stage, are also connected with imbalanced redox status of the embryo during its early developmental stage. Since high RNS levels are closely linked to male infertility and conventional semen analyses are not reliable predictors of the assisted reproductive technology (ART) outcomes for such infertility cases, it is critical to develop novel ways of assessing and treating oxidative and/or nitrosative stress-mediated male infertility. This review aims to explicate the physiological and pathological roles of RNS and their relationship with male reproduction.

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41

Yong, EL, Q. Wang, TG Tut, FJ Ghadessy, and SC Ng. "Male infertility and the androgen receptor: molecular, clinical and therapeutic aspects." Reproductive Medicine Review 6, no. 2 (July 1997): 113–31. http://dx.doi.org/10.1017/s0962279900001459.

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Idiopathic male infertility has previously been diagnosed imprecisely, and has been treated using regimes that are not based on a clear understanding of the underlying pathophysiology; however, this is gradually changing, and a more rational approach is being adopted. Testosterone and its metabolite, DHT, is allimportant for the maintenance of sperm production and this has led us to examine the AR for causes of male infertility. Some, but not all, androgen-binding studies have indicated that in a certain proportion of cases of male infertility, defective androgen binding occurs. The cloning of the AR gene allowed for a more rigorous examination of the molecular pathogenesis which turned out to be both subtle and heterogeneous. Genetic screening of a large group of men with defective spermatogenesis has indicated that up to 30% of infertile males could have variations in the androgenicity of their AR caused by polymorphisms in the length of the polyglutamine tract. Substitutions of the AR in the LBD and the DBD can also lead to reduced AR function and male infertility. In this regard, it is interesting to note that depressed spermatogenesis and prostate cancer represent opposite ends of the spectrum of AR action (Figure 6). Although empirical treatment of AR mutants in some cases has been shown to restore normal AR function and to improve spermatogenesis, a fully rational basis of treatment has to be based on an understanding of the crystallographic structure of the AR LBD. A full understanding could lead to the construction and the administration of ‘designer’ androgen analogues to treat male infertility caused by mutations of the AR gene.

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42

Marić, Tihana, Aleksandra Fučić, and Anna Aghayanian. "Environmental and occupational exposures associated with male infertility." Archives of Industrial Hygiene and Toxicology 72, no. 3 (June 1, 2021): 101–13. http://dx.doi.org/10.2478/aiht-2021-72-3510.

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Abstract The upsurge in male infertility over the last two decades, possibly due to environmental exposure, has raised significant interest, particularly boosted by reports from fertility clinics, which showed that chronic diseases and hereditary or other medical conditions might only partially explain current incidence of male infertility. Both environmental and occupational settings may have a significant role in exposure to complex mixtures of endocrine disruptors (ED), which play a major role in fertility disorders. The aim of this review is to give an insight into the current knowledge on exposure settings which may be associated with male infertility. Our study relied on a systematic search of PubMed, Scopus, and Web of Science for articles published between January 2000 and September 2020. It showed that some well documented factors associated with male infertility include smoking, and physiological disturbances or chronic diseases such as obesity and diabetes, which in turn, may also reflect lifestyle choices and environmental exposures, especially to EDs such as phthalates, bisphenols, pesticides, and flame retardants. However, the number of studies on the aetiology of male infertility is still too low in comparison with the size of affected population. Occupational health follow-ups and medical surveillance do not collect any data on male infertility, even though ED chemicals are part of many technological processes.

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43

Sharpe, R. M. "Lifestyle and environmental contribution to male infertility." British Medical Bulletin 56, no. 3 (January 1, 2000): 630–42. http://dx.doi.org/10.1258/0007142001903436.

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44

Moreira, Sergio G., and Larry I. Lipshultz. "Management of Male Infertility." Scientific World JOURNAL 4 (2004): 214–48. http://dx.doi.org/10.1100/tsw.2004.71.

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45

Ibishev, Kh S., E. A. Mamedov, and H. A. Magomedov. "The immunological aspects of male infertility: 2016 - 2020 literature review." Urology Herald 8, no. 3 (October 4, 2020): 97–102. http://dx.doi.org/10.21886/2308-6424-2020-8-3-97-102.

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46

Evenson, Donald P., and Regina Wixon. "Clinical aspects of sperm DNA fragmentation detection and male infertility." Theriogenology 65, no. 5 (March 2006): 979–91. http://dx.doi.org/10.1016/j.theriogenology.2005.09.011.

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47

Petrella, Carla, Matteo Spaziani, Valerio D’Orazi, Luigi Tarani, Sergio Terracina, Francesca Tarani, Ginevra Micangeli, et al. "Prokineticin 2/PROK2 and Male Infertility." Biomedicines 10, no. 10 (September 25, 2022): 2389. http://dx.doi.org/10.3390/biomedicines10102389.

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Male infertility represents about 50% of the causes of infertility in couples. The diagnosis process represents an important procedure for defining, when possible, the causes and approaching treatments (pharmacological, surgical) aimed at overcoming the problem. Several scientific studies have set out to discover early and indicative markers capable of providing information on the biological origin of infertility and increase current knowledge in the context of new potential therapeutic approaches. The prokineticin system (PROK) consists of the prokineticin 1 (PROK1) and prokineticin 2 (PROK2) proteins. Through the activation of two G-protein receptors (PROKR1 and PROKR2) regulate a wide range of biological functions, including gastrointestinal motility, circadian rhythm regulation, neurogenesis, angiogenesis, pain perception, and mood regulation. Several studies have highlighted the crucial role of the PROK system in the development and maturation of both male and female human reproductive organs. Particularly in men, the PROK system represents a new system useful to clarify some aspects of testicular pathophysiology and provide new potential hypotheses for therapeutic intervention. This narrative review aims to illustrate the state of the art regarding, in particular, the role of PROK2 in male infertility.

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48

Bonde, Jens Peter Ellekilde. "Occupational risk for male infertility." Occupational and Environmental Medicine 71, no. 9 (July 21, 2014): 596–97. http://dx.doi.org/10.1136/oemed-2014-102309.

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49

Strohmer, Heinz, Andrea Boldizsar, Barbara Plöckinger, Michel Feldner-Busztin, and Wilfried Feichtinger. "Agricultural work and male infertility." American Journal of Industrial Medicine 24, no. 5 (November 1993): 587–92. http://dx.doi.org/10.1002/ajim.4700240508.

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50

Aksoy, Ahu, and Duygu VefikuluÃ§ay Yilmaz. "Assessment of Male Infertility." International Journal of Emerging Trends in Health Sciences 3, no. 1 (June 1, 2019): 9–21. http://dx.doi.org/10.18844/ijeths.v3i1.4093.

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Анотація:

As a result of modern life, postponement of gestational age, obesity, electromagnetic waves, hormone and genetically modified foods, stress, smoking and alcohol use and sexually transmitted diseases directly cause negative effects on human health. The reproductive system, which is sensitive to environmental changes, is the most affected. In recent years, the usage of assisted reproductive techniques led to an increase in the number of men as well women who consults health institutions for assistance in conception. Because factors pertaining to males comprise half of all fertility problems. In this context, all these factors should be considered when assessing infertile men. Nowadays, many new methods such as endocrine tests, sperm analysis, radiological evaluation, testis biopsy, immunological tests and sperm function tests have been developed to diagnose and assess male infertility. Thanks to these methods, fertility success rates have increased. Therefore, when assessing infertile males, nurses should determine the condition causing fertility, provide accurate information about the prognosis, provide counseling during the research, provide support and training, and offer treatment options according to the evaluation results. Keywords: Infertility assessment, male infertility, fertility, nursing.

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