Дисертації з теми "Infection, Immunity and Inflammation"
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Phan, Quang Tien. "Innate immune response to tissue-specific infection : notochord infection in the zebrafish embryo." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT082/document.
Повний текст джерелаIn bacterial infections, according to the infected tissue and the nature of pathogens, the body responds by mobilizing various actors. I decided to use zebrafish or Danio rerio model to study the innate immune response to bacterial infection in the situations that professional phagocytes cannot come in direct contact with the bacteria. For this, I developed a model of infection in the notochord of zebrafish embryo. Upon injection of bacteria in this compartment, the microbes find themselves protected by the thick collagensheath where the phagocytes cannot penetrate. While mycobacteria are not detected by phagocytes; E. coli bacteria are sensed and a significant local inflammation around the notochord is mounted. The E. coli, although inaccessible to phagocytosis are eliminated within the first 24 hours after injection, the inflammation lasts several days.I studied the mechanisms that lead to this persistent inflammation and its long term consequences on the development of the fish. I showed the central role of the cytokine IL1B in this process, and I developed a transgenic line that allows studying in vivo the induction of this cytokine in fish.I then studied the roles of the two main populations of phagocytes in the elimination of E. coli. I revealed that macrophages are not involved in the removal of bacteria but neutrophils, although unable to penetrate inside the collagen casing, are necessary for the bacterial elimination. I also confirmed that myeloperoxidase and nitrogen monoxide are not involved in the removal of bacteria, rather the reactive oxygen species produced by neutrophils are needed to eradicate the infection
Ragheb, Ramy. "Etude de l'intéraction entre inflammation et infection chez la drosophile." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4104.
Повний текст джерелаLajunen, T. (Taina). "Persistent Chlamydia pneumoniae infection, inflammation and innate immunity." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514289965.
Повний текст джерелаThursfield, Rebecca Marie. "Infection, inflammation & innate immunity in the paediatric CF airway." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/43757.
Повний текст джерелаBlackshaw, Sasha. "The manipulation of inflammation, immunity and infection by novel derivatives of halichlorine." Thesis, Manchester Metropolitan University, 2017. http://e-space.mmu.ac.uk/618825/.
Повний текст джерелаMaurer, Kirk J. "A systematic evaluation of the role of infection, immunity and inflammation in cholesterol gallstone pathogenesis." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39917.
Повний текст джерелаIncludes bibliographical references.
Cholesterol gallstones are exceptionally common and cost nearly 10 billion U.S. dollars annually. Despite a half-century of basic and clinical research questions still remain about cholesterol gallstone pathogenesis. The purpose of the study presented herein is to analyze the roles of infection, and immunity in cholelithogenesis. The first two aims of this work were to analyze the role of enterohepatic Helicobacter spp. and the human gastric pathogen H. pylori in cholesterol gallstone formation. To test this, we prospectively infected C57UJ mice with a variety of Helicobacter spp. and fed infected and uninfected mice a lithogenic diet for eight weeks and analyzed biliary phenotype. Mice infected with H. bilis or coinfected with H. hepaticus and H. rodentium and fed a lithogenic diet developed cholesterol gallstones at 80% prevalence compared with approximately 10% in uninfected controls (P<0.05). Monoinfections with H. hepaticus, H. cinaedi, H. rodentium, and H. pylori gave a cholesterol gallstone prevalence of 40% (P<0.05), 30%, 20% and 20%, respectively; with the exception of H. hepaticus, cholesterol gallstone formation in these groups did not differ significantly from uninfected animals.
(cont.) These findings suggest that some Helicobacter spp. play a role in the cholesterol gallstone formation in mice and perhaps humans. We further hypothesized that inflammation and immunity were important in cholesterol gallstone formation and that cholelithogenic bacteria were promoting gallstones through immune stimulation. To test this we utilized BALB/c and isogenic Rag2-/- mice. When fed a lithogenic diet for eight-weeks, wild-type mice developed cholesterol gallstones (27-80% prevalence) significantly more than Rag2-/- mice (~5%, P<0.05). Transfer of functional splenocytes, or T-lymphocytes to Rag2-/- mice markedly increased cholesterol gallstone formation (26% and 40% respectively, P<0.05) whereas transfer of B-cells did not (13%). The presence of T-cells and solid cholesterol monohydrate crystals induced proinflammatory cytokine expression in the gallbladder. These studies indicate that T-cells are critical in murine cholelithogenesis and function by promoting gallbladder inflammation. In summary, these results illustrate that microbial pathogens can influence cholesterol gallstone formation; this most likely occurs by modulating the immune response with T-cells being a critical component in this immunomodulation.
by Kirk J. Maurer.
Ph.D.
Wachholz, Kristina Lora Catherine. "Placental Infection by Salmonella Typhimurium in a Murine Model: The Role of Innate Immune Mediators in Cell Death at the Fetal-Maternal Interface." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34190.
Повний текст джерелаLemaitre, Julien. "Heterogeneity of polymorphonuclear neutrophils in HIV-1 infection. Study of SIV-infected cynomolgus macaque model." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS267.
Повний текст джерелаEven under combinational antiretroviral treatments (cART), HIV-1 persistence is associated with chronic inflammation in infected patients, leading to an increased risk of non-AIDS-related comorbidities. Polymorphonuclear neutrophils (PMN), have been less studied in HIV infection whereas they were associated with chronic inflammation diseases. To evaluate PMN heterogeneity in SIVmac251 nonhuman primate infection model, we first performed multiparameter single-cell phenotyping by mass cytometry giving a global vision of the immune system. This analysis demonstrated circulation of immature PMN with impaired during chronic infection. Then, we characterized neutrophils heterogeneity in the course of SIV infection. In primary infection, there was an increased frequency of CD10- immature and CD62L-low primed PMNs in peripheral blood. In chronic phase, CD10- immature PMNs were significantly higher in bone marrow and blood, maintaining a primed profile. During SIV infection, PMNs demonstrated variable immunomodulatory function against T cells proliferation and cytokine production. Early cART allowed to restore PMN phenotype. In this study, we provide unprecedented insight into PMN heterogeneity in the course of SIV infection. Since PMN represent 40-70% of circulating leukocytes and primed PMN are more potent to release pro-inflammatory cytokines and to transmigrate, they should be considered as a new player in HIV-1 chronic inflammation
Sävykoski, née Huittinen T. (Tiina). "Chlamydia pneumoniae infection, inflammation and heat shock protein 60 immunity in asthma and coronary heart disease." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514269853.
Повний текст джерелаMarshall, Benjamin Giles. "Genetically modified mycobacteria as potential anti-tuberculous vaccines : an investigation of the links between inflammation, immunity and fibrosis in mycobacterial disease." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324918.
Повний текст джерелаAuma, Ann Winniefred Nangobi. "THE IMPACT OF DIRECT-ACTING ANTI-VIRAL THERAPY ON NAIVE CD4+ T CELL LYMPHOPENIA AND CELLULAR IMMUNE ACTIVATION IN HCV INFECTION AND HCV/HIV CO-INFECTION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1625764728651756.
Повний текст джерелаJanczy, John Roger. "Mechanisms for activation and inhibition of inflammasomes." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/1643.
Повний текст джерелаGumbi, Pamela. "HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity." Doctoral thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/10501.
Повний текст джерелаThe female genital tract serves as the major portal of entry for human immunodeficiency virus (HIV). Local immune factors unique to the mucosal micro-environment such as the genital tract cytokine milieu or the activation/differentiation status of T cells may play a significant role in heterosexual transmission of HIV and subsequent pathogenesis. Elucidation of the mechanisms underlying the persistent recruitment, activation and differentiation of mucosal T cells will give crucial insight into potential therapeutic targets to restore effective local immunity.
Karmarkar, Dipti. "Modulators of the Acute Inflammatory Response: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/656.
Повний текст джерелаKarmarkar, Dipti. "Modulators of the Acute Inflammatory Response: A Dissertation." eScholarship@UMMS, 2002. http://escholarship.umassmed.edu/gsbs_diss/656.
Повний текст джерелаTu, Fei. "Roles of Endothelial Cell Heat Shock Protein A12B and β-glucan, a reagent for trained Immunity in the Regulation of Inflammation in Sepsis". Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etd/3792.
Повний текст джерелаTu, Fei. "Roles of Endothelial Cell Heat Shock Protein A12B and β-glucan, a reagent for trained Immunity in the Regulation of Inflammation in Sepsis". Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etd/3792.
Повний текст джерелаAlanio, Bréchot Cécile. "Impact d'une infection virale chronique sur le répertoire T CD8 préimmun : à quel moment perd-on sa naiveté?" Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066376/document.
Повний текст джерелаThe CD8 preimmune repertoire is defined as the set of circulating antigen-specific T CD8 lymphocytes that have not been activated yet by their cognate antigen. Because those cells are very rare, they have not been evaluated in humans. We developed a tetramer-based enrichment protocol that allowed for the first time direct detection and enumeration of those rare naive antigen-specific CD8 T cells in healthys. We then used this tool to characterize the CD8 preimmune repertoire in patients with chronic hepatitis C viral infection. We found that their naive CD8 T cells are dysregulated, being hypersensitive to TCR signals, and with increased proportions of memory-phenotype (MP) cells in inexperienced populations. These perturbations are reversible after viral clearance, highlighting the added benefit of early antiviral treatment. Finally, using a transgenic model (OTI), we observed high proportions of MP inexperienced T cells in the blood of cxcr3-deficient unimmunized mice. This suggests that CXCR3-dependent lymphocyte trafficking could account for some preimmune repertoire alterations. Altogether, our work demonstrates that inexperienced T cells can lose their naiveté in several pathological situations. The impact of these findings will need to be considered when designing future immunotherapeutic strategies - especially when « inflammatory » patients are being targeted. Additionally, we highlight the challenge of interpreting T-cell immunophenotyping studies without getting knowledge into antigen-specific populations
Hopewell, Emily. "Enhancing the immune response through IKKbeta-induced activation of NF-kappaB." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4078.
Повний текст джерелаRantala, A. (Aino). "Susceptibility to respiratory tract infections in young men: the role of inflammation, mannose-binding lectin, interleukin-6 and their genetic polymorphisms." Doctoral thesis, University of Oulu, 2010. http://urn.fi/urn:isbn:9789514262937.
Повний текст джерелаTiivistelmä Hengitystieinfektiot ovat yleisimpiä äkillisiä sairauksia, ja synnynnäisellä immuunivasteella ja tulehduksella on tärkeä rooli puolustuksessa näitä infektioita vastaan. Synnynnäiseen immuniteettiin kuuluva mannoosia sitova lektiini (MBL) tunnistaa infektioita aiheuttavien mikrobien rakenteita. MBL2-geenin polymorfismien aiheuttaman MBL-proteiinin puutteen on todettu altistavan toistuville infektioille. Interleukiini-6 (IL-6) on tulehduksen välittäjänä toimiva sytokiini. IL-6- ja IL-6-reseptori (IL-6R) -geenien polymorfismit on aikaisemmin yhdistetty lähinnä metabolisiin häiriöihin sekä sydän- ja verisuonitauteihin. Chlamydia pneumoniae eli keuhkoklamydia on yleinen hengitystieinfektioiden aiheuttaja, mutta se voi myös aiheuttaa kroonisia infektioita, jotka on yhdistetty sydän- ja verisuonitauteihin sekä niiden riskitekijöihin kuten lihavuuteen. Työn tarkoituksena oli tutkia tiettyjen MBL2-, IL-6- ja IL-6R-geenien polymorfismien yhteyttä hengitystieinfektiohin ja keuhkoklamydiavasta-ainetasoihin sekä keuhkoklamydiainfektion yhteyttä painoindeksiin 893 suomalaisella varusmiehellä. Hengitystieinfektioita seurattiin palveluksen aikana, ja seeruminäytteet kerättiin palveluksen alussa, lopussa ja jokaisen infektion aikana. Tutkimuksessa havaittiin vaihtelua seerumin MBL-pitoisuudessa eri MBL2-genotyyppien välillä sekä MBL:n puute homotsygooteissa eksoni 1 -alueen varianttigenotyypeissä (kodoneissa 52, 54 ja 57). Alhaiset MBL-tasot sekä MBL2-geenin polymorfismit eksoni 1 -alueella ja säätelyalueella olivat riskitekijöitä hengitystieinfektioalttiudelle sekä keuhkoklamydiavasta-aineiden esiintymiselle ja vasta-aineiden nousulle palveluksen aikana. IL-6R-geenin polymorfismit säätelyalueella (-183G/A) ja introni 1 -alueella liittyivät hengitystieinfektioihin. Lisäksi IL-6-geenin -174G/C polymorfismi oli yhteydessä jatkuvasti kohonneisiin keuhkoklamydiavasta-aineisiin sekä seerumin C-reaktiivisen proteiinin (CRP) tasoihin, jotka mahdollisesti osoittaisivat kroonista keuhkoklamydiainfektiota. Lisäksi krooniseen keuhkoklamydia-infektioon viittaavat vasta-ainetasot sekä tulehdukseen liittyvä kohonnut CRP-pitoisuus olivat yhteydessä ylipainoon. Tutkimuksen tulokset tukevat aikaisemmin havaittua MBL:n vaikutusta infektioalttiuteen ja lisäksi antavat uutta tietoa MBL:n yhteydestä tavallisiin hengitystieinfektioihin. Tulokset viittaavat myös siihen, että IL-6R-geenin 5’-alueella voi olla yhteyttä hengitystieinfektioalttiuteen ja että IL-6-polymorfismi olisi yhteydessä keuhkoklamydiainfektioon. Tutkimus antaa myös uutta tietoa mahdollisen kroonisen keuhkoklamydiainfektion liittymisestä ylipainoon
Kheir, Saadé. "Etude d'une thérapie cellulaire par transplantation intrapulmonaire de macrophages dans le traitement d'une infection aigue à pseudomonas aeruginosa." Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7085.
Повний текст джерелаPseudomonas aeruginosa (P.a) is a Gram-negative bacillus responsible for chronic infections associated with high mortality due to the bacterium's predilection for developing antibiotic resistance and the inefficacy of current therapies. Our group showed in a model of acute infection in mice that Elastase B (LasB), a virulence factor of Pa, degrades the cytokine IL-6 and the antimicrobial molecule Elafine and that the overexpression of these two mediators provides protection to mice by decreasing inflammation and increasing repair. Alveolar macrophages represent the most abundant myeloid population in the alveolar space and play a key role in maintaining homeostasis, initiation and resolution of inflammation. Given their importance, they are very much studied in the development of new approaches to cell therapy. We therefore hypothesized that the alveolar macrophage which is also targeted by P.a and LasB more particularly, may be an adequate tool for the transfer of IL-6- and Elafine-mediated protection. The main objective of this work is to modify the macrophage with adenoviral vectors allowing the overexpression of IL-6 and Elafine, and to use it as a therapeutic tool in an intrapulmonary transplantation model followed by a Pa infection We show that the transfer of genetically modified macrophages with IL-6 and Elafine is protective. Elafine induces in the macrophage an IL6 / IL10 / antimicrobial peptide signature which, in synergy with IL-6, confers a regulatory phenotype to the alveolar unit
Stoicov, Calin. "Pathogenesis of the Helicobacter Induced Mucosal Disease: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/477.
Повний текст джерелаGhosh, Sreya. "Different Journeys, Same Destination: Exploring the Role of a PYHIN Protein and Involvement of Caspase-8 in the Regulation and Activation of Inflammasomes." eScholarship@UMMS, 2009. http://escholarship.umassmed.edu/gsbs_diss/928.
Повний текст джерелаGhosh, Sreya. "Different Journeys, Same Destination: Exploring the Role of a PYHIN Protein and Involvement of Caspase-8 in the Regulation and Activation of Inflammasomes." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/928.
Повний текст джерелаTextoris, Julien. "Réponse à l'infection : apport du transcriptome." Phd thesis, Université de la Méditerranée - Aix-Marseille II, 2011. http://tel.archives-ouvertes.fr/tel-00723077.
Повний текст джерелаRahman, Muhammad Jubayer. "Mucosal immunity against mycobacterial infection." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-39170.
Повний текст джерелаAt the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 4: Manuscript
Permpoonpattana, Patima. "Clostridium difficile : infection and immunity." Thesis, Royal Holloway, University of London, 2013. http://repository.royalholloway.ac.uk/items/33009ec4-7815-0803-d39b-f968c8d9cdbb/7/.
Повний текст джерелаWuttge, Dirk Marcus. "Cellular immunity and inflammation in atherosclerosis /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-7349-051-2/.
Повний текст джерелаSalzano, Sonia. "Redox regulation of inflammation and immunity." Thesis, University of Brighton, 2013. https://research.brighton.ac.uk/en/studentTheses/f28a2a37-9169-4b2a-abe8-ee83c6bfe86f.
Повний текст джерелаSilvera, Peter. "Immunity to Simian Imunodeficiency Virus infection." Thesis, Open University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242518.
Повний текст джерелаHolm, Angelika. "Aquaporins in Infection and Inflammation." Doctoral thesis, Linköpings universitet, Avdelningen för mikrobiologi och molekylär medicin, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-127500.
Повний текст джерелаThorpe, Callum. "Immunity and pathology to Chlamydia pneumoniae infection." Thesis, Imperial College London, 2006. http://hdl.handle.net/10044/1/11264.
Повний текст джерелаXie, Fang. "Infection and immunity in pregnancy and preeclampsia." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/30063.
Повний текст джерелаNoursadeghi, Mahdad. "Studies of innate immunity to bacterial infection." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406424.
Повний текст джерелаNixon, Douglas F. "Cytotoxic T cell immunity in HIV infection." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291435.
Повний текст джерелаLobbermann, Jens. "Regulation of immunity during viral lung infection." Thesis, Imperial College London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544288.
Повний текст джерелаWestman, Gabriel. "Herpesvirus Infection and Immunity in Neurocognitive Disorders." Doctoral thesis, Uppsala universitet, Infektionssjukdomar, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-247187.
Повний текст джерелаGlover, Maya. "Trickle infection and immunity to Trichuris muris." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/trickle-infection-and-immunity-to-trichuris-muris(0add74f1-05de-49a1-b54c-2dff9b523422).html.
Повний текст джерелаMuir, Peter. "Cytomegalovirus infection and immunity in homosexual men." Thesis, University of Edinburgh, 1985. http://hdl.handle.net/1842/20040.
Повний текст джерелаLubaki, Ndongala. "HIV-specific immunity Acute Infection Early disease (AIED)." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86794.
Повний текст джерелаVaccination started with Edward Jenner's success with smallpox immunization in 1796. Since then, a number of successful vaccines have been developed including, polio, measles, mumps, rubella, hepatitis B and influenza. The quest for an effective HIV-1 vaccine has proved to be very difficult because of specific characteristic of the virus, the lack of understanding of correlates of protection from infection and disease progression and the inadequacy of assays currently used to evaluate immune responses.
This thesis focuses on characterizing the qualitative and quantitative features of HIV-specific T cell immune responses in individuals in primary infection as well as their fate in progressive HIV disease. The rationale for studying individuals in primary HIV infection is that events during this phase of infection are believed to set the stage for the subsequent course of infection. We first developed an ELISPOT assay able to detect both IFN-γ and IL-2 secretion simultaneously. This assay was used for the comprehensive screening and characterization of responses to the entire HIV proteome in individuals during primary and chronic infections.
We showed that the dual color ELISPOT assay developed in our laboratory is capable of detecting 3 functional lymphocyte populations: single IFN-γ, dual IFN-γ/IL-2 and single IL-2 secreting cells. We demonstrated that this assay is sensitive, reproducible and able to detect both CD4+ and CD8+ T cell responses. We found that the breadth and magnitude of responses directed against the entire HIV proteome was not associated with control of viremia. Interestingly, we found an association between Gag p55-, and particularly Gag p24-specific responses, with concurrent and set point VL, for all 3 functional subsets detected. We also showed that the contribution of IFN-γ/IL-2 secreting cells to the total HIV-specific response as well as their proliferative capacity was reduced by the 2nd year of HIV infection.
Taken together, we believe that the results presented in this thesis contribute to furthering our understanding of immune correlates of protection from disease progression. These results suggest that vaccine strategies designed to focus immune responses against Gag may have a better chance of controlling HIV viral replication to levels that slow disease progression and reduce HIV transmission both at the individual and the population levels.
A ce jour, près de 33 millions d'individus sont infectés par le virus du VIH à travers le monde, parmi lesquels la majorité non seulement se retrouvent dans les pays de l'Afrique au Sud du Sahara mais aussi n'ont pas accès aux médicaments antiviraux, malgré les efforts soutenus de la communauté internationale.
Le meilleur moyen pour contrôler la pandémie serait la mise au point d'un vaccin efficace et bon marché. Jusqu'à ce jour, la mise au point de ce vaccin s'est avéré plutôt difficile car les corrélats de protection contre l'infection et le contrôle de la maladie ne sont pas encore élucidés.
Pour étudier la réponse immunitaire anti-VIH à médiation cellulaire, la communauté scientifique a besoin des tests plus adéquats. C'est ainsi que nous avons commencé par mettre au point une nouvelle stratégie basée sur l'ELISPOT qui consiste à détecter simultanément la sécrétion d'IFN-γ et d'IL-2 par les cellules VIH-spécifiques. Cette strategie permet d'étudier trois sous-populations des cellules T, aussi bien les cellules CD8+ que les cellules CD4+, les quelles réponses correspondent aux déterminants génétiques exprimés par le virus dans son entièreté.
En ce qui concerne les corrélats de protection contre l'évolution de la maladie, la contribution principale de ce travail de recherche est décrite dans le chapitre 3 de cette thèse. En effet, nous avons montré que la réponse VIH-spécifique reconnaissant le Gag p55 et plus spécifiquement le Gag p24 est associée au control de la virémie aussi bien pendant la primo infection qu'au set point. Ceci suggère que l'efficacité de la réponse immunitaire à médiation cellulaire naturellement acquise ou induite par vaccination dépend primordialement de la capacité de cibler cette portion du virus. En d'autres termes, la mise au point d'un vaccin efficace contre le virus VIH devrait essentiellement viser le développement des réponses cellulaires de forte magnitude dirigées contre le Gag du virus VIH
Dans le chapitre 3 de cette thèse, nous avons étudié l'évolution des différentes sous-populations des cellules VIH-spécifiques telles que détectées par l'ELISPOT à deux couleurs décrits dans le chapitre 2. Dans le même ordre d'idées, nous avons aussi étudié la capacité proliférative de ces sous-populations lymphocytaires pendant la primo infection et l'infection chronique. Nous avons montré que la contribution de la réponse immunitaire sécrétrice d'IFN-γ et d'IL-2 ainsi que leur capacité proliférative sont essentiellement réduites 2 ans après l'infection VIH.
En guise de conclusion, au regard des résultats décrits dans cette thèse, nous estimons avoir contribué à une meilleure compréhension des corrélats de protection contre l'évolution de la maladie. Nous avons en outre mis au point un test qui peut être utilisé pour détecter et analyser des réponses immunitaires à médiation cellulaire contre le VIH et cette stratégie peut être modifiée et adaptée en vue d'étudier la réponse immunitaire à médiation cellulaire contre d'autres virus ou des bactéries infectant les humains. Les résultats décrits dans ce travail de recherche suggèrent que la réponse VIH-spécifique induite par vaccination devrait viser particulièrement la portion Gag du virus en vue de réduire la réplication virale à des faibles taux. Ce qui devrait avoir un impact sur la progression de la maladie ainsi que la transmissibilité à l'échelle individuelle et collective.
Chowdhury, Abeed. "Infection and immunity in health and surgical disease." Thesis, University of Nottingham, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665483.
Повний текст джерелаMichalopoulou, Eleni. "'Chlamydophila abortus' : infection, persistence and immunity in sheep." Thesis, Royal Veterinary College (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415215.
Повний текст джерелаWilson, R. J. "Natural adaptive immunity to Streptococcus pneumoniae lung infection." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1417184/.
Повний текст джерелаWiddrington, John David. "The role of mitochondria in innate immunity and inflammation." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3196.
Повний текст джерелаBlohmke, Christoph Johannes. "Innate immunity and inflammation in cystic fibrosis lung disease." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/34559.
Повний текст джерелаMazdai, Goudarz. "The influence of mineral nutrients on immunity and inflammation." Thesis, University of Ulster, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281215.
Повний текст джерелаCroft, Nicholas Michael. "Investigation of gastrointestinal mucosal immunity and inflammation in children." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/21172.
Повний текст джерелаArnaout, Ramy A. "Mathematical models of antiviral immunity." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325989.
Повний текст джерелаShawcross, Deborah Lindsay. "Ammonia, infection and inflammation in hepatic encephalopathy." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445060/.
Повний текст джерелаWessel, Hannah Margaret. "Microbial infection and mechanisms of intestinal inflammation." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8377/.
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