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Добірка наукової літератури з теми "Induced-neural stem cells"

Автор: Grafiati

Опубліковано: 11 березня 2023

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Статті в журналах з теми "Induced-neural stem cells"

Kim, Jeong Beom, Holm Zaehres, Marcos J. Araúzo-Bravo, and Hans R. Schöler. "Generation of induced pluripotent stem cells from neural stem cells." Nature Protocols 4, no. 10 (September 17, 2009): 1464–70. http://dx.doi.org/10.1038/nprot.2009.173.

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Sun, Guoqiang, Chelsea Fu, Caroline Shen, and Yanhong Shi. "Histone Deacetylases in Neural Stem Cells and Induced Pluripotent Stem Cells." Journal of Biomedicine and Biotechnology 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/835968.

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Анотація:

Stem cells have provided great hope for the treatment of a variety of human diseases. However, the molecular mechanisms underlying stem cell pluripotency, self-renewal, and differentiation remain to be unveiled. Epigenetic regulators, including histone deacetylases (HDACs), have been shown to coordinate with cell-intrinsic transcription factors and various signaling pathways to regulate stem cell pluripotency, self-renewal, and fate determination. This paper focuses on the role of HDACs in the proliferation and neuronal differentiation of neural stem cells and the application of HDAC inhibitors in reprogramming somatic cells to induced pluripotent stem cells (iPSCs). It promises to be an active area of future research.

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Ma, Ming-San, Marcin Czepiel, Tina Krause, Karl-Herbert Schäfer, Erik Boddeke, and Sjef Copray. "Generation of Induced Pluripotent Stem Cells from Hair Follicle Bulge Neural Crest Stem Cells." Cellular Reprogramming 16, no. 5 (October 2014): 307–13. http://dx.doi.org/10.1089/cell.2014.0018.

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Shi, Zixiao, and Jianwei Jiao. "Direct lineage conversion: induced neuronal cells and induced neural stem cells." Protein & Cell 3, no. 11 (September 21, 2012): 826–33. http://dx.doi.org/10.1007/s13238-012-2068-8.

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Lee, Jangbo. "Induced Neural Stem Cells Protect Neuronal Cells against Apoptosis." Medical Science Monitor 20 (2014): 2759–66. http://dx.doi.org/10.12659/msm.891343.

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Shahbazi, Ebrahim, Fahimeh Mirakhori, Vahid Ezzatizadeh, and Hossein Baharvand. "Reprogramming of somatic cells to induced neural stem cells." Methods 133 (January 2018): 21–28. http://dx.doi.org/10.1016/j.ymeth.2017.09.007.

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Shin, Woo Jung, Ji‐Hye Seo, Hyun Woo Choi, Yean Ju Hong, Won Ji Lee, Jung Il Chae, Sung Joo Kim, et al. "Derivation of primitive neural stem cells from human‐induced pluripotent stem cells." Journal of Comparative Neurology 527, no. 18 (June 20, 2019): 3023–33. http://dx.doi.org/10.1002/cne.24727.

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TANG, Xihe, Meigang YU, Rui HUANG, Shengyong LAN, and Yimin FAN. "Comparative characterization of human fetal neural stem cells and induced neural stem cells from peripheral blood mononuclear cells." BIOCELL 44, no. 1 (2020): 13–18. http://dx.doi.org/10.32604/biocell.2020.07593.

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Xi, Guangjun, Pingfang Hu, Cunye Qu, Shenfeng Qiu, Chang Tong, and Qi-Long Ying. "Induced Neural Stem Cells Generated from Rat Fibroblasts." Genomics, Proteomics & Bioinformatics 11, no. 5 (October 2013): 312–19. http://dx.doi.org/10.1016/j.gpb.2013.09.003.

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Hermann, Andreas, and Alexander Storch. "Induced neural stem cells (iNSCs) in neurodegenerative diseases." Journal of Neural Transmission 120, S1 (May 30, 2013): 19–25. http://dx.doi.org/10.1007/s00702-013-1042-9.

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Дисертації з теми "Induced-neural stem cells"

Vicario, Nunzio. "Directly induced Neural Stem Cells transplantation and prospects for stem cell-based therapy." Doctoral thesis, Università di Catania, 2017. http://hdl.handle.net/10761/4088.

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Анотація:

Despite the remarkable beneficial effects of disease-modifying agents in relapsing-remitting multiple sclerosis (MS) patients, progressive forms of (P)MS still lack effective treatments. This stark contrast is partially dependent on the difficulties researchers have found in tackling the complex pathophysiology of this phase of disease, in which chronic inflammation within the central nervous system (CNS) is coupled by ongoing neurodegeneration and demyelination. Cell transplantation is among the most promising therapeutic approaches in regenerative medicine, combining tissue trophic and immunomodulatory effects of the graft with its intrinsic potential for cellreplacement. These are all attributes that can be harnessed to treated patients with PMS. As such, within this thesis, I have focused my attention on investigating how cellular therapies could be used to (i) prevent neuronal damage, (ii) modulate the chronic activation of the immune system and (iii) replace the damaged myelin in PMS. Olfactory Ensheathing Cells (OECs) are a special population of glial cells known to exert neuroprotective mechanisms and capable of promoting neuroprotection. Using in vitro models of neuron-like cells, I have demonstrated that OECs exert their neuroprotective effect by reducing Cx43-mediated cell-to-cell and cell-toextracellular environment communications. Despite this important finding, the immunomodulatory and remyelinating potential of OECs is still limited. As such, I decided to study a complementary stem cell approach that conjugates these attributes with ease in clinical applicability. Induced Neural Stem Cells (iNSCs) are a source of autologous, stably expandable, tissue specific and easily accessible stem cells, which have the potential to differentiate into the three main neural lineages. Mouse iNSCs were characterized in vitro and in vivo and their immunomodulatory potential was initially studied. This work uncovered a novel mechanism that underpins the potential of iNSCs to interact with the chronic CNS compartmentalised activation of the innate immune system. Specifically, I found that iNSCs are able to sense extracellular metabolites, which accumulate in the chronically inflamed CNS, and to ameliorate neuroinflammation via succinate-SUCNR1-dependend mechanisms. To characterize the potential for tissue replacement and remyelination of such a promising cell line, I have also analysed how iNSCs grafts differentiate in an experimental model of focal demyelination. I found that iNSCs are able to integrate and differentiate into remyelinating oligodendrocytes (OLs) in chronic demyelinated CNS. These data suggest that iNSCs are indeed an effective source of stem cell transplantation, being able to modulate inflammation and to effectively replace lost tissue in mouse models of PMS. Altogether the evidences gathered in this thesis are important new steps in the field of cell transplantation, which will be pivotal in the march forward for future clinical applications in chronic demyelinating CNS disorders.

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Yoshimatsu, Masayoshi. "In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265189.

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Анотація:

京都大学
新制・課程博士
博士(医学)
甲第23417号
医博第4762号
新制||医||1052(附属図書館)
京都大学大学院医学研究科医学専攻
(主査)教授松田秀一特定拠点, 教授妻木範行, 教授安達泰治
学位規則第4条第1項該当
Doctor of Medical Science
Kyoto University
DFAM

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Cullen, Daniel Kacy. "Traumatically-induced degeneration and reactive astrogliosis in three-dimensional neural co-cultures." Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-11282005-210117/.

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Thesis (Ph. D.)--Biomedical Engineering, Georgia Institute of Technology, 2006.
Robert McKeon, Committee Member ; Robert Lee, Committee Member ; Robert Guldberg, Committee Member ; Ravi Bellamkonda, Committee Member ; Michelle LaPlaca, Committee Chair. Vita.

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McLaughlin, Heather Ward. "Modeling sporadic Alzheimer's disease using induced pluripotent stem cells." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13094355.

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Анотація:

Despite being the leading cause of neurodegeneration and dementia in the aging brain, the cause of Alzheimer's disease (AD) remains unknown in most patients. The terminal pathological hallmarks of abnormal protein aggregation and neuronal cell death are well-known from the post-mortem brain tissue of Alzheimer's disease patients, but research into the earliest stages of disease development is hindered by limited model systems. In this thesis, an in vitro human neuronal system was derived from induced pluripotent stem (iPS) cell lines reprogrammed from dermal fibroblasts of AD patients and age-matched controls. This allows us to investigate the cellular mechanisms of AD neurodegeneration in the human neurons of sporadic AD (SAD) patients, whose development of the disease cannot be explained by our current understanding of AD. We show that neural progenitors and neurons derived from SAD patients show an unexpected expression profile of enhanced neuronal gene expression resulting in premature differentiation in the SAD neuronal cells. This difference is accompanied by the decreased binding of the repressor element 1-silencing transcription/neuron-restrictive silencer factor (REST/NRSF) transcriptional inhibitor of neuronal differentiation in the SAD neuronal cells. The SAD neuronal cells also have increased production of \(amyloid-\beta\) and higher levels of tau protein, the main components of the plaques and tangles in the AD brain.

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Ma, Shuang. "Preoptic Regulatory Factor 2 Inhibits Proliferation and Enhances Drug Induced Apoptosis in Neural Stem Cells." View abstract, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3353557.

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Alyamani, Najiah. "Molecular-genetics studies of organophosphate induced neurodegeneration in differentiating mammalian cell lines and neural progenitor stem cells." Thesis, Nottingham Trent University, 2018. http://irep.ntu.ac.uk/id/eprint/35003/.

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Анотація:

Organophosphorus (OP) pesticides are widely used despite evidence they cause neurotoxicity after exposure. The primary target for OPs is acetylcholinesterase, but there is evidence they can inhibit other cellular proteins including cytoskeletal and axon growth associated proteins, which are implicated in nervous system development. Furthermore, little is known about the ability of OPs to cause genotoxicity. The objectives of this study were to evaluate the effects of selected OPs on neurite outgrowth, expression of cytoskeletal proteins and associated gene expression levels, and to investigate histone deacetylation (HDAC) activity in three types of differentiating cell models. The initial findings indicated that cell viability was unaffected by exposure to 1, 3 and 10 µM CPF, CPO and PSP in N2a and C6 cells. A high content assay was sensitive enough to rapidly detect and quantify morphological changes, including inhibition of neurite number and length. Western blot and ELISA analysis in N2a and C6 cells revealed reduced levels of the selected cytoskeletal and associated regulatory proteins (MAP-2, Tau, βIII-tubulin, GAP43, NFH and GFAP) following the treatment with at least one concentration of CPF, CPO and PSP, which could be linked to the inhibition of neurite outgrowth. Using quantitative RT-PCR analysis on the total RNA of the genes MAP-2, TUBB3, MAPT, NEFH, GAP-43, and GFAP showed a good correlation between the altered protein expression and regulation of gene levels for most markers, which suggests these OPs can cause genotoxic effects. Increased levels of HDAC activity were observed for all OPs in rodent cell lines, suggesting that epigenetic effects may be at least partly involved in some gene expression changes. RT-PCR analysis of TUBB3, NEFH, and GFAP was also carried out in ReNcell CX cells, a co-culture of neuronal and glial cells, and showed down-regulation of gene levels for at least one concentration of all the OPs, as well as increasing the level of HDAC activity in a similar pattern to the results for N2a and C6 cells. Taken together, the data in this thesis suggest a novel action of OPs altering HDAC activity, which can be correlated to some of the observed changes in gene and protein levels of selected cytoskeletal and associated regulatory proteins that can be linked to the observed disruption of neurite outgrowth and neural development. Further work is needed to identify other molecular targets invoved in these phenomena, particularly when there is no correlation with HDAC activity changes.

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Joshi, Ramila Joshi. "Micro-engineering of embryonic stem cells niche to regulate neural cell differentiation." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1544029342969082.

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Kandasamy, Majury [Verfasser], Andreas [Gutachter] Faissner, and Beate [Gutachter] Brand-Saberi. "Investigations on the generation of neural stem cells derived from human induced pluripotent stem cells / Majury Kandasamy ; Gutachter: Andreas Faissner, Beate Brand-Saberi." Bochum : Ruhr-Universität Bochum, 2017. http://d-nb.info/113135463X/34.

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Marzec-Schmidt, Katarzyna. "Deep convolutional neural networks accurately predict the differentiation status of human induced pluripotent stem cells." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-19420.

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Анотація:

Rapid progress of AI technology in the life science area is observed in recent years. Convolutionalneural network (CNN) models were successfully applied for the localization and classification of cellson microscopic images. Induced pluripotent stem cells are one of the most important innovations inbiomedical research and are widely used, e.g. in regenerative medicine, drug screening, and diseasemodeling. However, assessment of cell cultures’ quality requires trained personnel, is timeconsumingand hence expensive. Fluorescence microscope images of human induced pluripotentstem‐hepatocytes (hiPS‐HEPs) derived from three human induced pluripotent stem cell (hiPSC) lineswere taken daily from day 1 until day 22 of differentiation. The cells from day 1 to 14 were classifiedas ´Early differentiation´, and above day 16 as ´Late differentiation´. In this study, it wasdemonstrated that a CNN‐based model can be trained with simple fluorescence microscope imagesof human induced pluripotent stem‐hepatocytes, and then used to predict with high accuracy(96.4%) the differentiation stage of an independent new set of images.

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Cullen, Daniel Kacy. "Traumatically-Induced Degeneration and Reactive Astrogliosis in 3-D Neural Co-Cultures: Factors Influencing Neural Stem Cell Survival and Integration." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/7584.

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Анотація:

Traumatic brain injury (TBI) results from a physical insult to the head and often results in temporary or permanent brain dysfunction. However, the cellular pathology remains poorly understood and there are currently no clinically effective treatments. The overall goal of this work was to develop and characterize a novel three-dimensional (3-D) in vitro paradigm of neural trauma integrating a robust 3-D neural co-culture system and a well-defined biomechanical input representative of clinical TBI. Specifically, a novel 3-D neuronal-astrocytic co-culture system was characterized, establishing parameters resulting in the growth and vitality of mature 3-D networks, potentially providing enhanced physiological relevance and providing an experimental platform for the mechanistic study of neurobiological phenomena. Furthermore, an electromechanical device was developed that is capable of subjecting 3-D cell-containing matrices to a defined mechanical insult, with a predicted strain manifestation at the cellular level. Following independent development and validation, these novel 3-D neural cell and mechanical trauma paradigms were used in combination to develop a mechanically-induced model of neural degeneration and reactive astrogliosis. This in vitro surrogate model of neural degeneration and reactive astrogliosis was then exploited to assess factors influencing neural stem cell (NSC) survival and integration upon delivery to this environment, revealing that specific factors in an injured environment were detrimental to NSC survival. This work has developed enabling technologies for the in vitro study of neurobiological phenomena and responses to injury, and may aid in elucidating the complex biochemical cascades that occur after a traumatic insult. Furthermore, the novel paradigm developed here may provide a powerful experimental framework for improving treatment strategies following neural trauma, and therefore serve as a valid pre-animal test-bed.

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Книги з теми "Induced-neural stem cells"

Nat, Roxana, and Andreas Eigentler. Cell Culture, iPS Cells and Neurodegenerative Diseases. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190233563.003.0013.

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Somatic reprogramming technology, which enables the conversion of adult human non-neural cells into neurons, has progressed rapidly in recent years. The derivation of patient-specific induced pluripotent stem (iPS) cells has become routine. The inherent broad differentiation potential of iPS cells makes possible the generation of diverse types of human neurons. This constitutes a remarkable step in facilitating the development of more appropriate and comprehensive preclinical human disease models, as well as for high throughput drug screenings and cell therapy. This chapter reviews recent progress in the human iPS cell culture models related to common and rare NDDs, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, spinal muscular atrophy, and degenerative ataxias. It focuses on the pathophysiological features revealed in cell cultures, and the neuronal subtypes most affected in NDDs. The chapter discusses the validity, limitation, and improvements of this system in faithfully and reproducibly recapitulating disease pathology.

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Частини книг з теми "Induced-neural stem cells"

Daadi, Marcel M. "Generation of Neural Stem Cells from Induced Pluripotent Stem Cells." In Methods in Molecular Biology, 1–7. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9007-8_1.

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Nishihara, Shoko. "Accelerated Neural Differentiation of Human Induced Pluripotent Stem Cells Using Chlorate Treatment." In Stem Cells and Cancer Stem Cells, Volume 7, 249–57. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-4285-7_24.

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Azmitia, Luis, and Philipp Capetian. "Single-Step Plasmid Based Reprogramming of Human Dermal Fibroblasts to Induced Neural Stem Cells." In Somatic Stem Cells, 31–41. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8697-2_2.

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Denham, Mark, and Mirella Dottori. "Neural Differentiation of Induced Pluripotent Stem Cells." In Methods in Molecular Biology, 99–110. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-328-8_7.

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Karanfil, Işıl, and Tugba Bagci-Onder. "Derivation of Neural Stem Cells from Mouse Induced Pluripotent Stem Cells." In Methods in Molecular Biology, 329–38. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/7651_2015_227.

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Zygogianni, Ourania, Georgia Kouroupi, Era Taoufik, and Rebecca Matsas. "Engraftable Induced Pluripotent Stem -Derived Neural Precursors for Brain Repair." In Stem Cells and Tissue Repair, 23–39. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0655-1_3.

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Yang, Jing, Sal Lee Goh, and Shu Wang. "Cancer Gene Therapy Potential of Neural Stem Cells Derived from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells." In Stem Cells and Cancer Stem Cells, Volume 11, 51–63. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-7329-5_5.

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Daadi, Marcel M. "Differentiation of Neural Stem Cells Derived from Induced Pluripotent Stem Cells into Dopaminergic Neurons." In Methods in Molecular Biology, 89–96. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9007-8_7.

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Hong, Hyenjong, Gourav Roy-Choudhury, Jeffrey Kim, and Marcel M. Daadi. "Isolation and Differentiation of Self-Renewable Neural Stem Cells from Marmoset-Induced Pluripotent Stem Cells." In Methods in Molecular Biology, 199–204. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9007-8_15.

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Jendelova, Pavla, Eva Sykova, and Slaven Erceg. "Neural Stem Cells Derived from Human-Induced Pluripotent Stem Cells and Their Use in Models of CNS Injury." In Results and Problems in Cell Differentiation, 89–102. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-93485-3_3.

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Тези доповідей конференцій з теми "Induced-neural stem cells"

Monteiro, Gary A., and David I. Shreiber. "Guiding Stem Cell Differentiation Into Neural Lineages With Tunable Collagen Biomaterials." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206752.

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The long-term objective of this research is to develop tunable collagen-based biomaterial scaffolds for directed stem cell differentiation into neural lineages to aid in CNS diseases and trauma. Type I collagen is a ubiquitous protein that provides mechanostructural and ligand-induced biochemical cues to cells that attach to the protein via integrin receptors. Previous studies have demonstrated that the mechanical properties of a substrate or tissue can be an important regulator of stem cell differentiation. For example, the mechanical properties polyacrylamide gels can be tuned to induce neural differentiation from stem cells [1, 2]. Mesenchymal stem cells (MSCs) cultured on ployacrylamide gels with low elastic modulus (0.1–1 kPa) resulted in a neural like population. MSCs on 10-fold stiffer matrices that mimic striated muscle elasticity (Emuscle ∼8–17 kPa) lead to spindle-shaped cells similar in shape to myoblasts. Still stiffer gels (25–40 kPa) resulted in osetoblast differentiation. Based on these observations, collagen gels may provide an ideal material for differentiation into neural lineages because of their low compliance.

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Rosati, Jessica, Eris Bidollari, Giovannina Rotundo, Angelo Luigi Vescovi, and Ferdinando Squitieri. "B18 Human induced neural stem cells as model to study the neural development in huntington’s disease." In EHDN 2018 Plenary Meeting, Vienna, Austria, Programme and Abstracts. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/jnnp-2018-ehdn.70.

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GOUVÊA JUNQUEIRA, DANIELLE, DANIEL MARTINS DE SOUZA, Giuliana Da Silva Zuccoli, and JULIANA M. NASCIMENTO. "Secretome Analyses of Induced Pluripotent Stem Cells-Derived Neural Progenitors Cells from Patients with Schizophrenia and Controls." In XXV Congresso de Iniciação Cientifica da Unicamp. Campinas - SP, Brazil: Galoa, 2017. http://dx.doi.org/10.19146/pibic-2017-77877.

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Cherkashova, Elvira, Veronika Burunova, Daria Namestnikova, Ilya Gubskiy, Tatiana Bukharova, Diasna Salikhova, Georgy Leonov, et al. "THE EFFECTIVENESS AND DISTRIBUTION OF INTRAVENOUS TRANSPLANTATION OF MESENCHYMAL STEM CELLS DERIVED FROM HUMAN PLACENTA AND NEURAL PROGENITOR CELLS DERIVED FROM INDUCED PLURIPOTENT STEM CELLS IN RATS WITH FOCAL CEREBRAL ISCHEMIA." In XVII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2021. http://dx.doi.org/10.29003/m2398.sudak.ns2021-17/417-418.

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Zocche Junior, Giovani, Isadora Ghilardi, Laura Provenzi, Gabriel Leal, Giulia Pinzetta, Nicole Becker, Vitoria Pimentel, et al. "Modulation of gene transcription promoted by mesenchymal stem cells on cation-chloride cotransporter NKCC1 in experimental epilepsy." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.684.

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Introduction: temporal lobe epilepsy is a disorder in which synchronized and rhythmic neural firing causes spontaneous recurrent seizures (1). Refractoriness due to this condition reaches 30% of its carriers (2,3). The search for therapeutic alternatives to help cope with this disease are extremely important. Mesenchymal stem cells (MSCs) appear as a plausible treatment option, as they present a less invasive approach and due to their niche modulating character (4,5). Objectives: this study aimed to quantify the gene expression of cation-chloride cotransporter NKCC1 encoded by the SLC12A2 gene in the encephalic tissue of pilocarpine-induced epileptic rats (6,7). Design: experimental study, brain institute of Rio Grande do Sul. Methods: MSCs were obtained from the bone marrow of Wistar rats, cultured, and transplanted through intravenous injection into control and epileptic Wistar rats. The rats were divided between control group, MSCs treated group, and pilocarpine group, containing 8 individuals each (8). Expression analysis was performed using real-time polymerase chain reaction. Results: for both 1 day and 7 days post-transplantation, an increase in the NKCC1 expression in both control and epileptic treated groups as compared to its expression in untreated epileptic and control groups with special attention to the amygdala, the hippocampus and the prefrontal cortex. Conclusion: MSCs stimulated expression of NKCC1 in brain structures of rats induced by pilocarpine to epilepsy. This corroborates the hypothesis of neuroprotective effects and modulating properties of stem cells and may point to more mechanisms for investigating the functioning and collaboration of these cells as a treatment for epilepsy.

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Ding, Dacheng, Ulf Kahlert, Jarek Maciaczyk, Guido Nikkhah, Charles Eberhart, and Eric Raabe. "Abstract 2607: BMI1 and dominant negative p53 cooperate to suppress AKT-mediated oncogene-induced senescence and promote transformation in human neural stem cells." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-2607.

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Ameku, Tomotsune. "Neural and endocrine control of mating-induced germline stem cell proliferation in femaleDrosophila." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.105760.

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Chang, Yuan-Hsiang, Kuniya Abe, Hideo Yokota, Kazuhiro Sudo, Yukio Nakamura, Cheng-Yu Lin, and Ming-Dar Tsai. "Human induced pluripotent stem cell region recognition in microscopy images using Convolutional Neural Networks." In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2017. http://dx.doi.org/10.1109/embc.2017.8037747.

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Vodickova Kepkova, Katerina, Jirina Tyleckova, Jakub Cervenka, Katerina Budkova, Ievgeniia Poliakh, and Petr Vodicka. "A13 Proteomic characterization of human induced pluripotent and neural stem cell lines from hd patients and healthy controls." In EHDN 2022 Plenary Meeting, Bologna, Italy, Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jnnp-2022-ehdn.13.

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Звіти організацій з теми "Induced-neural stem cells"

Anna-Liisa Brownell. Novel in vivo imaging techniques for trafficking the behavior of subventricular zone neural stem cells (SVZSC) and SVZSC induced functional repair. Office of Scientific and Technical Information (OSTI), November 2003. http://dx.doi.org/10.2172/819520.

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