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Добірка наукової літератури з теми "Inc Chessie System"

Автор: Grafiati
Опубліковано: 26 липня 2024
Оновлено: 28 липня 2024

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Статті в журналах з теми "Inc Chessie System"

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Noone, Declan, Gabriel Pedra, Sohaib Asghar, Jamie O'Hara, Eileen K. Sawyer, and Nanxin (Nick) Li. "Prophylactic Treatment in People with Severe Hemophilia B in the US: An Analysis of Real-World Healthcare System Costs and Clinical Outcomes." Blood 134, Supplement_1 (November 13, 2019): 2118. http://dx.doi.org/10.1182/blood-2019-126576.

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Introduction The treatment paradigm for people with severe hemophilia B in the US typically involves prophylaxis with factor IX (FIX) replacement therapy, the primary aim of which is to provide sufficient FIX levels to reduce the frequency of bleeding events. The clinical benefits of FIX prophylaxis are well understood, however the cost of FIX products as well as costs associated with healthcare resource utilization present a significant burden to the healthcare system. Substantive costs may also accrue in patients who continue to bleed while on prophylaxis, due to the impact on both short and long-term joint-related outcomes. In the absence of existing data in the US, the 'Cost of Hemophilia Across the USA: a Socioeconomic Survey' (CHESS US) study was conducted to establish a population-based estimate of the real-world US healthcare system burden associated with severe hemophilia. Using data drawn from the CHESS US study, this analysis examines the real-world healthcare system costs and clinical outcomes of people with severe hemophilia B on FIX prophylaxis. Methods CHESS US, a retrospective, cross-sectional dataset of adults with severe hemophilia in the USA, gathered information on patient cost via a patient record form. Data on the following parameters are included in this analysis: FIX consumption, annualized bleeding rate (ABR), the presence of one or more chronically damaged joints ("problem joint"), as well as costs associated with annual (prophylactic) factor consumption and hospitalizations (i.e., number of admissions, number of day cases, total inpatient days, and total intensive care unit [ICU] days). All variables report retrospective data of the 12 months prior to enrolment in the study. Results are presented as mean (± standard deviation) or N (%). Results In total, 132 of 576 patients profiled in the CHESS US study had severe hemophilia B. Among them, 77 patients were on FIX prophylaxis, of whom 44 patients reported FIX dosing regimen and were included in the current analyses. Among them, 20 patients were treated with conventional FIX and 24 patients with extended half-life (EHL) FIX products. The cohort has a mean age of 27.64 (± 11.05) and mean weight (kg) of 75.71 (± 13.41). In the last 12 months, the mean number of international units (IU) prescribed for FIX prophylaxis across the full cohort was 257,216 IU (± 213,591), with an associated annual cost of $610,966 (± $495,869). Among patients treated with conventional FIX, mean prescribed FIX was 287,141 IU (± 264,906) at an annual cost of $397,491 (± $359,788), while patients treated with EHL FIX reported a mean prescribed FIX of 232,278 IU (± 160,914) at an annual cost of $788,861 (± $529,258). The cohort reported a mean ABR of 1.73 (± 1.39); 8 (18%) were reported to have a target joint meeting the International Society on Thrombosis and Haemostasis (ISTH) definition; and 11% were reported to have had at least one chronically damaged joint (i.e., problem joint). Healthcare resource utilization associated with bleed events were reported as follows: hospital admissions days [0.18 (± 0.62)]; inpatient days [0.34 (± 1.22)]; and ICU days [0.23 (± 0.86)]. The direct medical cost to the healthcare system was $2,885 (± $7,857; excluding FIX cost) and $614,886 (± $498,839; including FIX cost). Discussion Data from the CHESS US study showed substantial costs and resource utilization among patients with severe hemophilia B receiving FIX prophylaxis, of which the cost of FIX replacement therapy constituted most of the total cost to healthcare system. Although the ABR observed in the analysis population was low, bleed-related hospitalizations comprised a significant non-drug cost to the healthcare system. A proportion of patients also still experienced joint arthropathy. Such substantial clinical and economic burden highlights that unmet needs remain in patients with severe hemophilia B on FIX prophylaxis in the US. Disclosures Noone: HCD Economics: Employment. Pedra:HCD Economics: Employment. Asghar:HCD Economics: Employment. O'Hara:HCD Economics: Employment, Equity Ownership. Sawyer:uniQure Inc.: Employment. Li:uniQure Inc.: Employment.
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Brown, Christopher S., Nigel J. Cassidy, Stuart S. Egan, and Dan Griffiths. "Numerical modelling of deep coaxial borehole heat exchangers in the Cheshire Basin, UK." Computers & Geosciences 152 (July 2021): 104752. http://dx.doi.org/10.1016/j.cageo.2021.104752.

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Mendes, B., C. Mazeda, D. Jesus, H. Assunção, A. Barcelos, L. Brites, D. Carvalho, et al. "POS1520 RELIABILITY STUDY OF THE SLE-DAS, SLEDAI-2K AND PGA INSTRUMENTS FOR MEASURING SLE DISEASE ACTIVITY." Annals of the Rheumatic Diseases 82, Suppl 1 (May 30, 2023): 1120. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4856.

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BackgroundThe Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) has been recently developed and validated, providing improved accuracy and sensitivity for changes in SLE disease activity in comparison to SLE Disease Activity Index 2000 (SLEDAI-2K)[1]. New recommendations to standardize the Physician Global Assessment (PGA) scoring may improve its reliability[2].ObjectivesTo assess the intra- and interrater reliability of SLE-DAS, SLEDAI-2K and PGA for measuring SLE disease activity.MethodsA set of 24 clinical vignettes were abstracted, each from a real clinical visit of patients followed at an academic lupus clinic. These vignettes were selected to include a wide spectrum of SLE manifestations, organ-system involvements, and global severity of disease activity. Abstracted data were presented in a standardized format, including demographic, past medical history, current clinical picture and treatment, laboratory, and other workup assessments. A group of 19 raters were recruited as a random multicenter sample of Rheumatologists. All raters completed a preliminary training session on scoring rules for SLE-DAS, SLEDAI-2K and PGA. Each rater scored each clinical vignette with SLE-DAS, SLEDAI-2K, and PGA through an online survey. The scoring was repeated in a second round 7-14 days after the first one. The clinical vignettes were randomly ordered for each round. Inter and intra-rater reliability of each instrument was estimated using the intraclass correlation coefficient (ICC) with 95% confidence intervals (95%CI), based on single-measurement, absolute agreement, with a two-way random effect or two-way mixed-effects model, respectively.ResultsThe 19 raters included 8 rheumatologists and 11 rheumatology trainees from 11 hospitals, with a mean of 12.1±7.1 and 3.6±0.5 years of rheumatology practice, respectively, and 78.9% of the participants assess ≤5 SLE patients per week in their regular clinical practice. The 24 clinical vignettes included 83.3% female patients, with a mean of 36.5±17.9 years of age. Active SLE organ involvement included: skin rashes (20.8%); arthritis (12.5%); nephritis (12.5%); thrombocytopenia (12.5%); cardiac/pulmonary involvement (12.5%); mucocutaneous vasculitis (8.3%); serositis (8.3%); neuropsychiatric lupus (8.3%). Systemic vasculitis, myositis, alopecia, hemolytic anemia, and leukopenia were each present in 4.2% of the vignettes. Hypocomplementemia and/or high anti-dsDNA were present in 75.0%. Twenty-one percent of the cases were in remission.All raters completed the survey, totaling 912 case assessments. Scores attributed by the raters ranged from 0.37 to 49.53 in SLE-DAS, 0 to 24 in SLEDAI-2K, and 0.0 to 3.0 in PGA. The interrater reliability was good for SLE-DAS and SLEDAI-2K, and moderate for PGA. The intra-rater reliability was excellent for SLE-DAS, and good for SLEDAI-2K and PGA (Table 1).Table 1:Interrater and intra-rater reliability of SLE-DAS, SLEDAI-2K and PGA.ICC (95%CI)Interrater reliabilityIntra-rater reliabilitySLE-DAS0.877 (0.807-0.934)0.908 (0.891-0.923)SLEDAI-2K0.812 (0.717-0.896)0.892 (0.871-0.909)PGA0.704 (0.578-0.828)0.900 (0.881-0.916)CI: confidence interval; ICC: intraclass correlation coefficient.ConclusionSLE-DAS presents high intra- and interrater reliability for measuring SLE disease activity. The high reliability of SLE-DAS is an important quality both in clinical practice and research, allowing consistent scoring among different clinicians including those who are not SLE experts.References[1] Jesus D, Matos A, Henriques C, et al. Derivation and validation of the SLE Disease Activity Score (SLE-DAS): a new SLE continuous measure with high sensitivity for changes in disease activity.Ann Rheum Dis2019;78:365-71.[2] Piga M, Chessa E, Morand EF, et al. Physician Global Assessment International Standardisation Consensus in Systemic Lupus Erythematosus: the PISCOS study. Lancet Rheumatol 2022;4:e441-e449.AcknowledgementsBeatriz Mendes and Carolina Mazeda contributed equally and share first authorship.Disclosure of InterestsNone Declared.
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Книги з теми "Inc Chessie System"

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Dixon, Thomas W. The Chessie era. Sterling, Va: TLC Pub., 1990.

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Bluman, Allan R. The PATrain: Pittsburgh's last commuter train. [United States]: A.R. Bluman, 2005.

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Eddy, Andy. Super NES Games Secrets. Rocklin, CA: Prima Publishing, 1992.

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Chessie System Diesel Locomotives. TLC Publishing, 1999.

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Biery, Thomas A. Chessie System Cumberland Action. Railroad Press, 1999.

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Ori, Dave. Chessie System (MBI Railroad Color History). Voyageur Press, 2006.

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Jr, Thomas W. Dixon. Chessie System: Railroads in West Virginia. The Chesapeake & Ohio Historical Society, 2008.

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Fields, Randall K. Chessie System Color Guide to Freight Equipment. Morning Sun Books, 2003.

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Hipes, Steven Thomas. The abandonment of rail lines in the Chicago-Cincinnati corridor. 1993.

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Govindaraj, V. C. Private International Law. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199489282.001.0001.

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In deciding cases of private international law or conflict of laws, as it is widely known, judges of the Supreme Court in India generally consult the works of renowned English jurists like Dicey and Cheshire. This volume argues that our country should have its own system of resolving inter-territorial issues with cross-border implications. The author critically analyses cases covering areas such as the law of obligations, the law of persons, the law of property, foreign judgments, and foreign arbitral awards. The author provides his perspectives on the application of law in each case. The idea is to find out where the judges went wrong in deciding cases of private international law, so that corrective measures can be taken in future to resolve disputes involving complex, extra-territorial issues.
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Частини книг з теми "Inc Chessie System"

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Lepri, Bruno, Cesare Rocchi, and Massimo Zancanaro. "Motivational Strategies for an Intelligent Chess Tutoring System." In Lecture Notes in Computer Science, 246–50. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/11590323_28.

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Lane, Peter C. R., and Fernand Gobet. "Using Chunks to Categorise Chess Positions." In Research and Development in Intelligent Systems XXIX, 93–106. London: Springer London, 2012. http://dx.doi.org/10.1007/978-1-4471-4739-8_7.

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Fang, Jianjun. "A Machine Vision System for Chinese Chess-Playing Robot." In Advances in Intelligent and Soft Computing, 379–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-27329-2_52.

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Sood, Suraj. "Could IBM’s Deep Blue Chess Program Feel Triumphant?" In Lecture Notes in Networks and Systems, 783–89. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-98012-2_55.

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Kamat, Vaishnavi Ketan. "Chessography: A Cryptosystem Based on the Game of Chess." In Advances in Intelligent Systems and Computing, 309–24. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-3874-7_29.

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Dzerjinsky, Roman I., Daniil A. Boldin, and Sofia G. Daeva. "MIREAHMATY—Three-Dimensional Chess in the System of Virtual Reality VR." In Artificial Intelligence Application in Networks and Systems, 356–66. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-35314-7_32.

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Yen, Shi-Jim, Cheng-Wei Chou, Jr-Chang Chen, I.-Chen Wu, and Kuo-Yuan Kao. "The Art of the Chinese Dark Chess Program DIABLE." In Advances in Intelligent Systems and Applications - Volume 1, 231–42. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-35452-6_25.

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Agarwal, Yash, Ashish Kumar, Roheet Bhatnagar, and Sumit Srivastava. "Identifying Non-pulsar Radiation and Predicting Chess Endgame Result Using ARSkNN." In Smart Systems and IoT: Innovations in Computing, 691–700. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8406-6_65.

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Choudhary, Harshit, Aniket Inamdar, Swapnil Kharade, Anunay Maheshwari, and Preeti Kale. "Comparative Analysis of Minimax Algorithm with Alpha–Beta Pruning Optimization for Chess Engine." In Lecture Notes in Networks and Systems, 237–47. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-4284-8_19.

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Huang, Chunfang. "Research and Analysis on the Search Algorithm Based on Artificial Intelligence About Chess Game." In Advances in Intelligent Systems and Computing, 509–17. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-67071-3_60.

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Тези доповідей конференцій з теми "Inc Chessie System"

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Christie, Dennis Aprilla, Tubagus Maulana Kusuma, and Purnawarman Musa. "Chess piece movement detection and tracking, a vision system framework for autonomous chess playing robot." In 2017 Second International Conference on Informatics and Computing (ICIC). IEEE, 2017. http://dx.doi.org/10.1109/iac.2017.8280621.

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Shuo, Wang, Li Yan, Du Ping, Zuo Jing, Jiang Xiaona, Wang Yating, and Zhang Qichang. "Speech Recognition Based Blind Chess Education System Chinese Chess as an Example." In 2021 11th International Conference on Information Technology in Medicine and Education (ITME). IEEE, 2021. http://dx.doi.org/10.1109/itme53901.2021.00115.

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Chole, Vikrant, and Vijay Gadicha. "Hybrid Optimization for Developing Human Like Chess Playing System." In 2022 IEEE 3rd Global Conference for Advancement in Technology (GCAT). IEEE, 2022. http://dx.doi.org/10.1109/gcat55367.2022.9971825.

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Muji, Siti Zarina Mohd, Mohd Helmy Abdul Wahab, Radzi Ambar, and Wong Kian Loo. "Design and implementation of electronic chess set." In 2016 International Conference on Advances in Electrical, Electronic and Systems Engineering (ICAEES). IEEE, 2016. http://dx.doi.org/10.1109/icaees.2016.7888087.

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Vuckovic, Vladan. "The Realization of the Parallel Chess System Using UDP Communication Protocol." In 2007 8th International Conference on Telecommunications in Modern Satellite, Cable and Broadcasting Services. IEEE, 2007. http://dx.doi.org/10.1109/telsks.2007.4376036.

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Lei, Yang, Liu Wenlong, Pan Sigan, and Han Jiu-Qiang. "MobileNet based Chinese Chess recognition with Xavis Platform." In 2021 IEEE International Conference on Recent Advances in Systems Science and Engineering (RASSE). IEEE, 2021. http://dx.doi.org/10.1109/rasse53195.2021.9686923.

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Sondur, Sanjeev, Girisha Shankar, and Krishna Kant. "CHeSS: A Configuration Health Scoring System and Its Application to Network Devices." In 2020 23rd Conference on Innovation in Clouds, Internet and Networks and Workshops (ICIN). IEEE, 2020. http://dx.doi.org/10.1109/icin48450.2020.9059494.

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