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Статті в журналах з теми "IN939"

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Автор: Grafiati

Опубліковано: 14 березня 2023

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1

Marchese, Giulio, Simone Parizia, Abdollah Saboori, Diego Manfredi, Mariangela Lombardi, Paolo Fino, Daniele Ugues, and Sara Biamino. "The Influence of the Process Parameters on the Densification and Microstructure Development of Laser Powder Bed Fused Inconel 939." Metals 10, no. 7 (July 3, 2020): 882. http://dx.doi.org/10.3390/met10070882.

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Анотація:

This work aims to investigate the effect of the process parameters on the densification and microstructure of Inconel 939 (IN939) alloy processed by laser powder bed fusion (LPBF). IN939 is a Ni-based superalloy with high creep and corrosion resistance that can be used up to around 850 °C under load, resulting in higher operative temperatures than the ones commonly allowed for Inconel 718 and Inconel 625 alloys (around 650 °C). However, this alloy can suffer from poor weldability involving possible crack formation. In order to minimize the residual porosity and the cracking density, specific process parameters were investigated. The parameters to generate IN939 samples almost pores-free (porosity ≤0.22%) with a cracking density ≤1.36 mm/mm2 as well as samples almost crack-free (≤0.10 mm/mm2) with limited residual porosity (≤0.89%) were determined. The microstructure revealed fine dendritic/cellular structures with the formation of sub-micrometric phases. A high concentration of these phases was also found along the intergranular cracks, suggesting that their presence, coupled to the high thermal stresses, can be the primary reason for crack formation during the LPBF process.

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2

Zschau, Hans Eberhard, Daniel Renusch, Patrick J. Masset, and Michael Schütze. "Formation of a Protective Alumina Scale on Ni-Base Superalloys by Using the Halogen Effect." Advanced Materials Research 278 (July 2011): 485–90. http://dx.doi.org/10.4028/www.scientific.net/amr.278.485.

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A new method is proposed to achieve a dense protective alumina scale for Ni-base superalloys with an Al-content lower than 10 wt.% at temperatures above 1000°C. The method is based on the halogen effect. Thermodynamical calculations show the existence of a region for a positive fluorine effect at temperatures between 900-1200°C for the alloys IN738 and IN939. By using fluorine ion implantation in combination with Monte Carlo simulation of the fluorine profiles these results were transformed into a region of F-concentrations at the metal surface. A dense protective alumina scale was formed for IN738 after oxidation at 1050°C. Due to the very low Al-content no alumina scale was found for IN939.

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3

Jie, Ziqi, Zhaoning Yang, Tao Xu та Chongfeng Sun. "Effect of Nano-Sized γ′ Phase on the Ultrasonic and Mechanical Properties of Ni-Based Superalloy". Nanomaterials 12, № 23 (24 листопада 2022): 4162. http://dx.doi.org/10.3390/nano12234162.

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The effect of the nano-sized γ′ phase on the ultrasonic and mechanical properties of the IN939 superalloy was investigated. The results indicate that the microstructure characteristics of the nano-sized γ′ phase directly affected the ultrasonic longitudinal velocity, the attenuation coefficient, and the mechanical properties. The ultrasonic longitudinal velocity increased with the volume fraction of the γ′ phase, whereas the attenuation coefficient was similar to the fractional change in the γ channel width. The lower fractional change in the γ channel width, in combination with a high volume fraction of the γ′ phase, was conducive to improving the mechanical properties of the superalloy. Additionally, the variation in the ultrasonic properties could reflect the variation in the mechanical properties of the IN939 superalloy, which was beneficial for optimizing the heat treatment process and characterizing the γ′ phase precipitation behavior in a nondestructive manner.

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4

Jahangiri, M. R., H. Arabi, and S. M. A. Boutorabi. "Development of wrought precipitation strengthened IN939 superalloy." Materials Science and Technology 28, no. 12 (December 2012): 1470–78. http://dx.doi.org/10.1179/1743284712y.0000000073.

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5

Nakahashi, Masako, Makoto Shirokane, and Hiromitsu Takeda. "Transient Liquid Phase Bonding for MarM-247 and IN939." Journal of the Japan Institute of Metals 54, no. 7 (1990): 826–31. http://dx.doi.org/10.2320/jinstmet1952.54.7_826.

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6

Jahangiri, M. R., H. Arabi, and S. M. A. Boutorabi. "High-Temperature Compression Behavior of Cast and Homogenized IN939 Superalloy." Metallurgical and Materials Transactions A 44, no. 4 (December 11, 2012): 1827–41. http://dx.doi.org/10.1007/s11661-012-1538-1.

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7

Zschau, Hans Eberhard, Patrick J. Masset, and Michael Schütze. "The Halogen Effect for Ni-Base Superalloys – A Thermodynamic Study." Materials Science Forum 638-642 (January 2010): 2375–80. http://dx.doi.org/10.4028/www.scientific.net/msf.638-642.2375.

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Анотація:

A new method for the oxidation protection of Ni-base superalloys with relatively low Al-content is proposed. By using the halogen effect the Al activity on the surface can be increased. Thus, the formation of a pure protective alumina scale becomes possible. The alloys IN738 and IN939 are considered in the present paper. Thermodynamic calculations for fluorine and chlorine predict the existence of the halogen effect for both alloys at temperatures between 900°C and 1200°C. The results also predict a change of the oxidation mechanism from internal alumina formation to external oxidation.

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8

Nakahashi, Masako, Seiichi Suenaga, Makoto Shirokane, and Hiromitsu Takeda. "Transient Liquid Phase Bonding for Ni-base Superalloys, Mar-M247 and IN939." Materials Transactions, JIM 33, no. 1 (1992): 60–65. http://dx.doi.org/10.2320/matertrans1989.33.60.

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9

Moattari, M., M. M. Shokrieh, H. Moshayedi, and H. Kazempour-Liasi. "Evaluations of residual stresses in repair welding of Ni-based IN939 superalloy." Journal of Thermal Stresses 43, no. 7 (April 24, 2020): 801–15. http://dx.doi.org/10.1080/01495739.2020.1751759.

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10

Formenti,, A., A. Eliasson,, A. Mitchell, та H. Fredriksson,. "Solidification Sequence and Carbide Precipitation in Ni-Base Superalloys Ιn718, In625 and In939". High Temperature Materials and Processes 24, № 4 (серпень 2005): 239–58. http://dx.doi.org/10.1515/htmp.2005.24.4.239.

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11

Xie, Jilin, Yingche Ma, Weiwei Xing, Long Zhang, Meiqiong Ou, and Kui Liu. "Heat-affected zone crack healing in IN939 repaired joints using hot isostatic pressing." Welding in the World 62, no. 3 (March 26, 2018): 471–79. http://dx.doi.org/10.1007/s40194-018-0579-5.

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12

Li, Yang, Xiaoyu Liang, Yefeng Yu, Hongxin Li, Wenbin Kan, and Feng Lin. "Microstructures and mechanical properties evolution of IN939 alloy during electron beam selective melting process." Journal of Alloys and Compounds 883 (November 2021): 160934. http://dx.doi.org/10.1016/j.jallcom.2021.160934.

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13

Formenti,, A., A. Eliasson, та H. Fredriksson,. "On the Dendritic Growth and Microsegregation in Ni-Base Superalloys Ιn718, In625 and In939". High Temperature Materials and Processes 24, № 4 (серпень 2005): 221–38. http://dx.doi.org/10.1515/htmp.2005.24.4.221.

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14

Kazempour-Liasi, Hassan, Mohammad Tajally, and Hassan Abdollah-Pour. "Liquation cracking in the heat-affected zone of IN939 superalloy tungsten inert gas weldments." International Journal of Minerals, Metallurgy and Materials 27, no. 6 (June 2020): 764–73. http://dx.doi.org/10.1007/s12613-019-1954-y.

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15

Banoth, Santhosh, Chen-Wei Li, Yo Hiratsuka, and Koji Kakehi. "The Effect of Recrystallization on Creep Properties of Alloy IN939 Fabricated by Selective Laser Melting Process." Metals 10, no. 8 (July 28, 2020): 1016. http://dx.doi.org/10.3390/met10081016.

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Анотація:

In this research, we studied the creep properties of a selective laser melting (SLM)-processed γ′-strengthened IN939 superalloy along the building direction compared to a conventional cast alloy as a reference specimen. In the as-built condition, high-density dislocations were formed as a result of the SLM process due to the generation of the larger thermal gradient. Post-heat treatment was necessary to obtain specific mechanical properties to match industrial requirements. Two heat treatment conditions were used: the first was lower temperature heat treatment (LTH: solution treatment at 1160 °C/4 h + aging at 850 °C/16 h). The second was higher temperature heat treatment (HTH: solution treatment at 1240 °C/6 h + aging at 850 °C/16 h). Creep tests were conducted at 816 °C/250 MPa. The first and second heat treatment conditions were used for the SLM specimens, but only the first condition was used for the cast alloy (cast-LTH). The SLM specimens in the as-built and LTH conditions showed very poor creep life but good elongation. The poor creep life of the as-built specimen was caused by high dislocation density and the small recrystallized grains formed during testing. In the LTH specimen, poor creep life was due to the formation of the undesirable η phase at the grain boundary, as well as the formation of small recrystallized grains during testing. The creep life of the HTH specimen was 2.7 times longer compared to the LTH specimen. This was because these specimens were covered with recrystallized grains that included low-density dislocations, columnar grain morphology with random orientation, improvement in γ′ precipitate size, and elimination of undesirable η phase. The cast LTH specimen showed longer creep life than SLM specimens because of coarser grains with low-density dislocations, γ′ precipitate coarsening during the creep, and the presence of carbides at grain boundaries. In addition, the cast LTH specimen exhibited lower creep strain rate than SLM specimens also helped in creep life improvement.

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16

Abedini, M., M. R. Jahangiri, and P. Karimi. "Rejuvenation of the microstructure and mechanical properties of a service-exposed IN939 superalloy by heat treatments." Materials at High Temperatures 36, no. 1 (March 12, 2018): 19–26. http://dx.doi.org/10.1080/09603409.2018.1448529.

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17

JAHANGIRI, M. R., H. ARABI, and S. M. A. BOUTORABI. "Comparison of microstructural stability of IN939 superalloy with two different manufacturing routes during long-time aging." Transactions of Nonferrous Metals Society of China 24, no. 6 (June 2014): 1717–29. http://dx.doi.org/10.1016/s1003-6326(14)63245-3.

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18

Wimmer, Thomas, York Mick, and Bernhard Weigand. "Experimental investigation into capabilities of laser powder bed fusion to produce wavy macro-channels from IN939." Additive Manufacturing 35 (October 2020): 101345. http://dx.doi.org/10.1016/j.addma.2020.101345.

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19

Moattari, M., M. M. Shokrieh, and H. Moshayedi. "Effects of residual stresses induced by repair welding on the fracture toughness of Ni-based IN939 alloy." Theoretical and Applied Fracture Mechanics 108 (August 2020): 102614. http://dx.doi.org/10.1016/j.tafmec.2020.102614.

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20

Lee, K. N., C. A. Barrett, and J. Smith. "Long-Term Cyclic Oxidation Behavior of Uncoated and Coated RE108 and IN939 at 980 and 870 °C." Journal of Thermal Spray Technology 9, no. 1 (March 1, 2000): 121–27. http://dx.doi.org/10.1361/105996300770350159.

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21

Abedini, M., M. R. Jahangiri, and P. Karimi. "Oxidation and Hot Corrosion Behaviors of Service-Exposed and Heat-Treated Gas Turbine Vanes Made of IN939 Alloy." Oxidation of Metals 90, no. 3-4 (April 6, 2018): 469–84. http://dx.doi.org/10.1007/s11085-018-9847-4.

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22

Jahangiri, M. R., S. M. A. Boutorabi, and H. Arabi. "Study on incipient melting in cast Ni base IN939 superalloy during solution annealing and its effect on hot workability." Materials Science and Technology 28, no. 12 (December 2012): 1402–13. http://dx.doi.org/10.1179/1743284712y.0000000090.

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23

Kazempour-Liasi, H., M. Tajally, and H. Abdollah-Pour. "Effects of pre- and post-weld heat treatment cycles on the liquation and strain-age cracking of IN939 superalloy." Engineering Research Express 1, no. 2 (November 4, 2019): 025026. http://dx.doi.org/10.1088/2631-8695/ab4d6c.

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24

Jahangiri, M. R., and M. Abedini. "Effect of long time service exposure on microstructure and mechanical properties of gas turbine vanes made of IN939 alloy." Materials & Design 64 (December 2014): 588–600. http://dx.doi.org/10.1016/j.matdes.2014.08.035.

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25

Alizadeh, Mohammd Reza. "Simulation of Ni-Based Super-Alloy and Optimizing of Its Mechanical Properties in a Near-Shaped Turbine Blade Part." Indian Journal of Materials Science 2015 (April 15, 2015): 1–6. http://dx.doi.org/10.1155/2015/413593.

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Анотація:

This paper presents simulation of a Ni-based super-alloy during filling of a near-shaped turbine blade part to optimize its mechanical properties. Since geometrical shape of the airfoil is so complicated, a simple near-shaped part was made by plexiglass to water modeling. Condition and parameters of water modeling were obtained from the Procast software simulation. The flow pattern of the transparent systems, recorded by a high speed video camera, was analyzed. Air bubble amounts were quantitatively measured by an image analysis software. Quantified results were used to compare two systems in terms of ability to prevent bubble formation and entrainment. Both water modeling and computer simulating methods indicated that highest turbulences in bottom- and top-poured systems form in first initially pouring times. According to the water modeling results amount of bubble values was 40 and 18 percent for top-poured and bottom-poured systems, respectively. Then the Ni-base super-alloy IN939 is poured by investment casting in bottom- and top-poured systems and compared with each other. The results stated that bottom-poured system had higher mechanical properties compared to top-poured one. Ultimate tensile strength for the former was 820 MPa while for the part which was cast by bottom-poured system it was 850 MPa.

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26

Sadeghian, Amirhossein, Seyyed Ehsan Mirsalehi, Farzam Arhami, Ahmad Malekan, Noritaka Saito, and Kunihiko Nakashima. "Effect of Bonding Time on Dissimilar Transient Liquid Phase (TLP) Bonding of IN939 to IN625 Superalloys: Microstructural Characterization and Mechanical Properties." Metallurgical and Materials Transactions A 52, no. 4 (March 2, 2021): 1526–39. http://dx.doi.org/10.1007/s11661-021-06176-x.

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27

Sadeghian, Amirhossein, Farzam Arhami, and Seyyed Ehsan Mirsalehi. "Phase formation during dissimilar transient liquid phase (TLP) bonding of IN939 to IN625 using a Ni-Cr-Fe-Si-B interlayer." Journal of Manufacturing Processes 44 (August 2019): 72–80. http://dx.doi.org/10.1016/j.jmapro.2019.05.027.

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28

Dupke, Rüdiger, and Walter Reimers. "X-ray Diffraction Investigations on Individual Grains in the Polycrystalline Ni-base Superalloy IN939 During Cyclice Loading I: X-ray Rocking Curve Broadening." International Journal of Materials Research 86, no. 5 (May 1, 1995): 371–77. http://dx.doi.org/10.1515/ijmr-1995-860515.

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29

Kazempour-Liasi, H., M. Tajally, and H. Abdollah-Pour. "A Study on Microstructure and Phase Transformation in the Weld Fusion Zone of TIG-Welded IN939 with IN625 and IN718 as Filler Metal." Metallurgical and Materials Transactions A 51, no. 5 (March 2, 2020): 2163–79. http://dx.doi.org/10.1007/s11661-020-05690-8.

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30

CAETANO, T., S. FERREIRA, A. P. MONDEGO, A. CORREIA, and S. MENDO. "In99, an In100-related integron, its occurrence and prevalence in clinical Pseudomonas aeruginosa strains from a central region of Portugal." Epidemiology and Infection 135, no. 3 (July 26, 2006): 502–4. http://dx.doi.org/10.1017/s095026880600700x.

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In99, a possible ancestor of In100, is a class 1 integron associated with carbenicillinase (blaPSE) and aminoglycoside resistance genes [aac(6′)-Ib and aadA2]. In99 was present in 8 of 81 clinical isolates of Pseudomonas aeruginosa from unrelated patients collected in different years. The strains fell into two clonal groups and exhibited resistance to β-lactams and aminoglycosides.

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31

Moreh, R., W. M. Sandefur, W. C. Sellyey, D. C. Sutton, and B. H. Wildenthal. "Ground stateM1 strengths ofd5/2−1levels inK39." Physical Review C 37, no. 6 (June 1, 1988): 2428–34. http://dx.doi.org/10.1103/physrevc.37.2428.

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32

Kargar, Z., and F. Mosaleh. "Thermal phase transition in93−98Mo nuclei." Physica Scripta 83, no. 3 (March 1, 2011): 035201. http://dx.doi.org/10.1088/0031-8949/83/03/035201.

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33

Matsushita, I., and H. Yanase. "The Genomic Structure of Thermus Bacteriophage IN93." Journal of Biochemistry 146, no. 6 (August 12, 2009): 775–85. http://dx.doi.org/10.1093/jb/mvp125.

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34

Lassmann, H. "IN39-WE-01 Pathological complexity and heterogeneity." Journal of the Neurological Sciences 285 (October 2009): S30. http://dx.doi.org/10.1016/s0022-510x(09)70144-3.

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35

Shi, Yuhua, Qian Lv, Mengjie Zheng, Hongxiang Sun, and Fushan Shi. "NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages." International Immunopharmacology 92 (March 2021): 107358. http://dx.doi.org/10.1016/j.intimp.2020.107358.

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36

Iglesias, Lindsy E., James F. Price, Craig R. Roubos, Justin M. Renkema, and Oscar E. Liburd. "Spotted Wing Drosophila in Florida Berry Culture." EDIS 2016, no. 3 (May 6, 2016): 5. http://dx.doi.org/10.32473/edis-in839-2016.

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Анотація:

Spotted wing drosophila, Drosophila suzukii (Matsumura) (Diptera: Drosophilidae), is an invasive pest that was introduced into Florida in 2009. Spotted wing drosophila survives well under Florida’s climatic conditions. In 2014, losses to berry crops in Florida were estimated at $35 million. Losses are due to maggot-infested fruit, which is unacceptable for the fresh berry market, and puncture holes in the fruit made by egg-laying females. The holes lead to secondary infection by fungal and bacterial pathogens. This revised 5-page fact sheet describes the flies and some strategies to identify them and manage them in berry operations. Written by Lindsy E. glesias, James F. Price, Craig R. Roubos, Justin M. Renkema, and Oscar E. Liburd, and published by the Department of Entomology and Nematology, January 2016. ENY-861/IN839: Spotted Wing Drosophila in Florida Berry Culture (ufl.edu)

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37

Kreger, M. A., N. J. Cherepy, J. Z. Zhang, J. C. Scott, G. Klaerner, R. D. Miller, D. W. McBranch, B. Kraabel, and S. Xu. "Femtosecond study of exciton dynamics in9,9−di−n−hexylfluorene/anthracenerandom copolymers." Physical Review B 61, no. 12 (March 15, 2000): 8172–79. http://dx.doi.org/10.1103/physrevb.61.8172.

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38

Leng, Bin, Yingjie Zhang, Xinran Liu, Zhen Zhang, Yang Liu, Hongxin Wang та Meili Lu. "Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR". Mediators of Inflammation 2019 (18 лютого 2019): 1–16. http://dx.doi.org/10.1155/2019/1082497.

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Анотація:

Long-term exposure to high glucose induces vascular endothelial inflammation that can result in cardiovascular disease. Astragaloside IV (As-IV) is widely used for anti-inflammatory treatment of cardiovascular diseases. However, its mechanism of action is still not fully understood. In this study, we investigated the effect of As-IV on high glucose-induced endothelial inflammation and explored its possible mechanisms. In vivo, As-IV (40 and 80 mg/kg/d) was orally administered to rats for 8 weeks after a single intraperitoneal injection of streptozotocin (STZ, 65 mg/kg). In vitro, human umbilical vein endothelial cells (HUVECs) were treated with high glucose (33 mM glucose) in the presence or absence of As-IV, NPS2143 (CaSR inhibitor), BAY 11-7082 (NF-κB p65 inhibitor), and INF39 (NLRP3 inhibitor), and overexpression of CaSR was induced by infection of CaSR-overexpressing lentiviral vectors to further discuss the anti-inflammatory property of As-IV. The results showed that high glucose increased the expression of interleukin-18 (IL-18), interleukin-1β (IL-1β), NLRP3, caspase-1, and ASC, as well as the protein level of TLR4, nucleus p65, and CaSR. As-IV can reverse these changes in vivo and in vitro. Meanwhile, NPS2143, BAY 11-7082, and INF39 could significantly abolish the high glucose-enhanced NLRP3, ASC, caspase-1, IL-18, and IL-1β expression in vitro. In addition, both NPS2143 and BAY 11-7082 attenuated high glucose-induced upregulation of NLRP3, ASC, caspase-1, IL-18, and IL-1β expression. In conclusion, this study suggested that As-IV could inhibit high glucose-induced NLRP3 inflammasome activation and subsequent secretion of proinflammatory cytokines via inhibiting TLR4/NF-κB signaling pathway and CaSR, which provides new insights into the anti-inflammatory activity of As-IV.

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39

Nevo, Y. "INV39 Childhood acute and chronic immune-mediated polyneuropathies: definitions, treatment and outcome." European Journal of Paediatric Neurology 11 (September 2007): 17. http://dx.doi.org/10.1016/s1090-3798(08)70303-9.

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40

Stadelmann, C. "IN39-WE-03 Grey matter damage and repair in autoimmune demyelination." Journal of the Neurological Sciences 285 (October 2009): S30. http://dx.doi.org/10.1016/s0022-510x(09)70146-7.

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41

Prineas, J. "IN39-WE-02 Oligodendrocyte apoptosis and demyelination in multiple sclerosis and neuromyelitis optica." Journal of the Neurological Sciences 285 (October 2009): S30. http://dx.doi.org/10.1016/s0022-510x(09)70145-5.

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42

HUSSAIN, UZMA, AFSHAN SAEED, and FARZANA LATIF. "WOUND INFECTION." Professional Medical Journal 17, no. 01 (March 10, 2010): 64–67. http://dx.doi.org/10.29309/tpmj/2010.17.01.1983.

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Objective: To evaluate the effects of the anaemia in wound infection after cesarean section. Design: Prospective study. Setting:Department of Obstetric-Gynaecology in Sir Ganga Ram Hospital / Fatima Jinnah Medical College Lahore. Period: Sep 2008 to Sep 2009.Patients and Methods: The study comprises of 100 pregnant women with moderate to severe anaemia. Selected cases underwent cesareansection due to different indications. The rate and frequency of wound infection was observed in all these women. Results were analysed andtabulated. Results: 100 cases with moderate to severe anaemia who underwent cesarean section were included. Moderate aneamia wasrecognized in 55% of cases and 19% with severe anaemia. Wound discharge was seen in 44 % of cases and wound dehiscence was foundin 56 % cases. Culture was positive in 41 % patients and majority of these were unbooked. Non elective cesarean delivery was performed in99% of cases. Conclusion: The rate of wound infection was very high in moderate to severely anemic women who underwent non elective/ emergency cesarean section.

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Jalasvuori, Matti, Silja T. Jaatinen, Simonas Laurinavičius, Elina Ahola-Iivarinen, Nisse Kalkkinen, Dennis H. Bamford, and Jaana K. H. Bamford. "The Closest Relatives of Icosahedral Viruses of Thermophilic Bacteria Are among Viruses and Plasmids of the Halophilic Archaea." Journal of Virology 83, no. 18 (July 8, 2009): 9388–97. http://dx.doi.org/10.1128/jvi.00869-09.

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ABSTRACT We have sequenced the genome and identified the structural proteins and lipids of the novel membrane-containing, icosahedral virus P23-77 of Thermus thermophilus. P23-77 has an ∼17-kb circular double-stranded DNA genome, which was annotated to contain 37 putative genes. Virions were subjected to dissociation analysis, and five protein species were shown to associate with the internal viral membrane, while three were constituents of the protein capsid. Analysis of the bacteriophage genome revealed it to be evolutionarily related to another Thermus phage (IN93), archaeal Halobacterium plasmid (pHH205), a genetic element integrated into Haloarcula genome (designated here as IHP for integrated Haloarcula provirus), and the Haloarcula virus SH1. These genetic elements share two major capsid proteins and a putative packaging ATPase. The ATPase is similar with the ATPases found in the PRD1-type viruses, thus providing an evolutionary link to these viruses and furthering our knowledge on the origin of viruses.

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Gastaldi, Simone, Valentina Boscaro, Eleonora Gianquinto, Christina F. Sandall, Marta Giorgis, Elisabetta Marini, Federica Blua, et al. "Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazole-2-one Scaffold as a Novel NLRP3 Inhibitor." Molecules 26, no. 13 (June 29, 2021): 3975. http://dx.doi.org/10.3390/molecules26133975.

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In the search for new chemical scaffolds able to afford NLRP3 inflammasome inhibitors, we used a pharmacophore-hybridization strategy by combining the structure of the acrylic acid derivative INF39 with the 1-(piperidin-4-yl)1,3-dihydro-2H-benzo[d]imidazole-2-one substructure present in HS203873, a recently identified NLRP3 binder. A series of differently modulated benzo[d]imidazole-2-one derivatives were designed and synthesised. The obtained compounds were screened in vitro to test their ability to inhibit NLRP3-dependent pyroptosis and IL-1β release in PMA-differentiated THP-1 cells stimulated with LPS/ATP. The selected compounds were evaluated for their ability to reduce the ATPase activity of human recombinant NLRP3 using a newly developed assay. From this screening, compounds 9, 13 and 18, able to concentration-dependently inhibit IL-1β release in LPS/ATP-stimulated human macrophages, emerged as the most promising NLRP3 inhibitors of the series. Computational simulations were applied for building the first complete model of the NLRP3 inactive state and for identifying possible binding sites available to the tested compounds. The analyses led us to suggest a mechanism of protein–ligand binding that might explain the activity of the compounds.

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Wang, Yue, Bo Song, Jiebiao Chen, Jinping Cao, Xian Li, and Chongde Sun. "Polymethoxyflavones in Citrus Regulate Lipopolysaccharide-Induced Oscillating Decay of Circadian Rhythm Genes by Inhibiting Nlrp3 Expression." Oxidative Medicine and Cellular Longevity 2021 (September 14, 2021): 1–15. http://dx.doi.org/10.1155/2021/8419415.

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The aim of this study is to compare the regulatory abilities of citrus flavonoids on the oscillating expression of circadian genes. Seven varieties of citrus fruits and twenty-five citrus flavonoids were selected and evaluated. Per2 luciferase bioluminescence report system and serum shock were used to induce circadian gene expression in mouse microglia BV-2 cells. In vivo experiments were carried out using C57BL6/J mice to evaluate the regulation of flavonoids on the oscillatory expression of liver biorhythm genes. Lipopolysaccharide was used to interfere the gene oscillating expression. QRT-PCR was performed to detect the expression of circadian rhythm-related genes, including Clock, Bmal1, Per1, Per2, Per3, Cry1, Cry2, Rev-erbα, Rev-erbβ, Rorα, Dbp, and Npas2. The results show that the polymethoxyflavones (PMFs) exerted stronger circadian gene regulatory capability, while the flavonoids containing glycosides showed no biological activity. Also, all tested flavonoids decreased LPS-induced nitric oxide release, but only polymethoxyflavones inhibited circadian rhythm disorder. PMFs inhibited Nlrp3 inflammasome-related genes and proteins, including Nlrp3, IL-1β, ASC, and Caspase1, while other flavonoids only affected IL-1β and Caspase1 expression. This mechanism was preliminarily verified using the Nlrp3 inhibitor INF39.

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in ‘t Veld, Laurike. "Introducing the Rwandan Genocide from a distance: American noir and the animal metaphor in99 Days." Journal of Graphic Novels and Comics 6, no. 2 (April 3, 2015): 138–53. http://dx.doi.org/10.1080/21504857.2015.1027941.

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Su, Qiang, Wei Kuang, Weiyi Hao, Jing Liang, Liang Wu, Chunmei Tang, Yali Wang, and Tao Liu. "Antituberculosis Drugs (Rifampicin and Isoniazid) Induce Liver Injury by Regulating NLRP3 Inflammasomes." Mediators of Inflammation 2021 (February 19, 2021): 1–13. http://dx.doi.org/10.1155/2021/8086253.

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Patients being treated for pulmonary tuberculosis often suffer liver injury due to the effects of anti-TB drugs, and the underlying mechanisms for those injuries need to be clarified. In this study, rats and hepatic cells were administrated isoniazid (INH) and rifampin (RIF) and then treated with NLRP3-inflammasome inhibitors (INF39 and CP-456773) or NLRP3 siRNA. Histopathological changes that occurred in liver tissue were examined by H&E staining. Additionally, the levels IL-33, IL-18, IL-1β, NLRP3, ASC, and cleaved-caspase 1 expression in the liver tissues were also determined. NAT2 and CYP2E1 expression were identified by QRT-PCR analysis. Finally, in vitro assays were performed to examine the effects of siRNA targeting NLRP3. Treatment with the antituberculosis drugs caused significant liver injuries, induced inflammatory responses and oxidative stress (OS), activated NLRP3 inflammasomes, reduced the activity of drug-metabolizing enzymes, and altered the antioxidant defense system in rats and hepatic cells. The NLRP3 inflammasome was required for INH- and RIF-induced liver injuries that were produced by inflammatory responses, OS, the antioxidant defense system, and drug-metabolizing enzymes. This study indicated that the NLRP3 inflammasome is involved in antituberculosis drug-induced liver injuries (ATLIs) and suggests NLRP3 as a potential target for attenuating the inflammation response in ATLIs.

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Carrillo-Cabrera, Wilder, Nubia Caroca-Canales, and Hans Georg von Schnering. "K21-?Na2+?In39 (? = 2.8): A Cluster-Replacement Clathrate-II Structure with an Alkali Metal M136-Network." Zeitschrift f�r anorganische und allgemeine Chemie 620, no. 2 (February 1994): 247–57. http://dx.doi.org/10.1002/zaac.19946200208.

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49

Hanudin, Hanudin, Lia Sanjaya, and Budi Marwoto. "Bacterial Leaf Blight Disease (Pseudomonas cichorii (Swingle 1925) (STAPP 1928) in Chrysanthemum (Dendranthema grandiflora Tzvelev) and Its Control) in Indonesia." Jurnal Penelitian dan Pengembangan Pertanian 39, no. 2 (December 3, 2020): 105. http://dx.doi.org/10.21082/jp3.v39n2.2020.p105-116.

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<p>Bacterial leaf blight caused by Pseudomonas cichorii is a major disease in chrysanthemum plants almost all over the world. In Indonesia, this pathogen can cause damage to chrysanthemum 10- 60%. Bacteria spread from one plant to another through water droplets from modern irrigation networks as well as conventional irrigation. P. cichorii is a polyphagic pathogen, which infects succulents and others across continents with varying incidence. Symptoms of transmission of this pathogen in each type of plant are always different, and effective control methods have not been found. This article discusses the virulence of pathogens, the incidence of transmission, and recommendations for controlling bacterial leaf blight on chrysanthemums in Indonesia. A search of various references from within and outside the country shows that P. cichorii can be controlled by combining several methods, namely (a) the use of tolerant varieties (Puspita Nusantara, Puspa Kania, Dwina Kencana, Dwina Pelangi, Pasopati, Paras Ratu, and Wastu Kania), (b) technical culture (extracting infected leaves and watering in the morning), and (c) application of synthetic chemical bactericides with active ingredients of hydrogen peroxide and peroxyacetic acid, or biopesticides with active bacterial isolates of the antagonistic bacteria Bacillus subtilis MI600, and B. amyloliquefaciens IN937, and combination of P. fluorescens Pf Irana with Pf Slada-2.</p><p>Keywords: Chrysanthemum, P. chicorii, bacterial leaf blight disease, epidemiology, control</p><p> </p><p><strong>Abstrak</strong></p><p><strong>PENYAKIT HAWAR DAUN BAKTERI (Pseudomonas cichorii (Swingle 1925) (STAPP 1928) PADA TANAMAN KRISAN (Dendranthema grandiflora Tzvelev) DAN UPAYA PENGENDALIANNYA DI INDONESIA</strong></p><p>Hawar daun bakteri yang disebabkan oleh Pseudomonas cichorii merupakan penyakit utama pada tanaman krisan hampir di seluruh penjuru dunia. Di Indonesia, patogen ini dapat menyebabkan kerusakan pada tanaman krisan 10-60%. Bakteri menyebar dari satu tanaman ke tanaman lain melalui tetesan air dari jaringan irigasi modern maupun penyiraman konvensional. P. cichorii merupakan patogen yang bersifat polifag, yang menginfeksi tanaman sukulen dan lainnya di seluruh benua dengan insidensi bervariasi. Gejala penularan patogen ini pada setiap jenis tanaman selalu berbeda, dan belum ditemukan metode pengendalian yang efektif. Artikel ini membahas virulenitas patogen, insidensi penularan, dan rekomendasi pengendalian hawar daun bakteri pada tanaman krisan di Indonesia. Penelusuran dari berbagai referensi dari dalam dan luar negeri menunjukkan P. cichorii dapat dikendalikan dengan memadukan beberapa metode, yaitu (a) penggunaan varietas toleran (Puspita Nusantara, Puspa Kania, Dwina Kencana, Dwina Pelangi, Pasopati, Paras Ratu, dan Wastu Kania), (b) kultur teknis (perompesan daun terinfeksi dan penyiraman pada pagi hari), serta (c) aplikasi bakterisida kimia sintetik berbahan aktif hydrogen peroxide dan peroxyacetic acid, atau biopestisida berbahan aktif isolat bakteri antagonis Bacillus subtilis MI600, dan B. amyloliquefaciens IN937, serta kombinasi P. fluorescens Pf Irana dengan Pf Slada-2.</p><p>Kata kunci: Krisan, P. chicorii, bakteri hawar daun, epidemiologi, pengendalian.</p>

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Hájek, Petr, Eva Kaňková, and Gulnar Zhunissova. "Analysis of competitiveness and economic profit of the confectionary sector in Kazakhstan and its comparison with Czech Republic data." International Food and Agribusiness Management Review 25, no. 2 (February 28, 2022): 263–91. http://dx.doi.org/10.22434/ifamr2020.0206.

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Measuring competitiveness in post-communist countries in Central Asia is challenging. Many well-known metrics fail to warn bankruptcy risks sufficiently early or at all. This study uses metrics of the Altman z-score, Taffler z-score, IN99, IN01, IN05, and creditworthiness models to assess bankruptcy likelihood and financial performance of local and foreign confectionery companies operating in Kazakhstan during 2007-2018. These companies are Roshen, KDV Yaskino, Konti, Rakhat, and Bayan Sulu. The IN bankruptcy and creditworthiness models are considered in this study because they are found to be more appropriate for post-communist countries. Compared to the well known Altman or Taffler z-score models, they better suit the events and corporate situations peculiar to these countries. The benchmarking INFA system, involving a pyramidal approach developed for Czech companies, provides the economic-value-added (EVA) and component indicators to analyze competitiveness. This study also compares the performance of Kazakhstan companies with Nestlé Czechia and the Czech food industry. The objective is to analyze company competitiveness, bankruptcy probability, and ability to create value. Results show the effectiveness of INFA in analyzing competitiveness and the applicability of IN models to companies from Kazakhstan, Russia, Ukraine, and the Czech Republic.

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