Дисертації з теми "In vivo experiments on rats"
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GuimarÃes, SÃrgio Botelho. "In vivo acute changes in ATP and glucose concentrations in the rat testicles following unilateral torsion: experimental study." Universidade Federal do CearÃ, 2002. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=21.
Повний текст джерелаSpematic cord torsion is one of the more common surgical urological emergencies in childhood. An experimental study has been conducted to investigate acute changes in testicular concentrations of ATP and glucose following one-hour unilateral 720Â testicular torsion. Sixty prepubertal male Wistar rats were distributed into two groups: Group 2(Ischemia) and Group 1(Sham operated). Each group(n=30) was divided into 5 subgroups (n=6). All animals were subjected to right testicular torsion of 720Â. The testicular torsion of animals from Group 1 was immediately corrected. Group 2 animals had their testicular torsion lasting one hour followed by detorsion. Testicles were collected and arterial blood samples taken from abdominal aorta of each animal subgroup at the and of ischemic period or one hour after sham operation and 0.5, 1,6 and 24 hours later. ATP and glucose concentrations were significantly decreased (p<0,05) in ischemia group as compared to sham group at the end of ischemic period. There was no difference in glycemia when comparing ischemic versus sham-operated rats. Glucose concentrations were significantly increase (p<0,05) in ipsilateral testis of sham-operated rats No significant change in ATP and glucose concentrations were found in the left testicle in comparasion to the ones measured in the rigth testicle of the same animal. The decrease in ATP and glucose concentrations may be explained by the reduction in blood flow to the torted testis imposed by torsion. The absence of significant contralateral alterations in the concentrations of ATP and glucose could be related to the limited time of isquemia imposed to the right testis. It is concluded that unilateral one-hour testicular torsion causes a decrease in ipsilateral testicular perfusion resulting in decresead testicular concentrations of glucose and ATP in the ipstelial (right) testicles and no alterations in the concentrations of glucose and ATP in the contraleral testicles. Simple testicle manipulation (Sham Operation) causes a signficant increase in glucose concentrations in the ipsilateral(right)testis.
A torÃÃo do cordÃo espermÃtico à a emergÃncia geniturinÃria mais comum na idade pediÃtrica. Foram estudadas as alteraÃÃes metabÃlicas agudas nas concentraÃÃes testiculares de ATP e glicose apÃs uma hora de isquemia induzida por torÃÃo do cordÃo espermÃtico. Sessenta ratos wistar machos prÃ-pÃberes, foram distribuÃdos em 2 grupos de 30 animais cada e cada grupo em 5 subgrupos de 6 ratos. Os ratos do grupo 1 foram submetidos à torÃÃo seguida por distorÃÃo imediata (cirurgia simulada) do testÃculo direito. Os animais do grupo 2 foram submetidos à torÃÃo do testÃculo direito (720o) durante uma hora. Os animais dos diferentes subgrupos foram sacrificados 30 minutos, 1 hora, 6 horas e 24 horas apÃs a distorÃÃo ou realizaÃÃo da cirurgia simulada para a remoÃÃo dos testÃculos e coleta de amostra de sangue arterial. As alteraÃÃes das concentraÃÃes de glicose e ATP foram determinadas por mÃtodos enzimÃticos. Ocorreu queda significante (p<0,05) da concentraÃÃo de glicose e ATP no tempo 0 h, nos testiculos isquemiados. NÃo ocorreram alteraÃÃes na glicemia nem nas concentraÃÃes de glicose e ATP nos testÃculos contralaterais. Os animais submetidos à cirurgia simulada apresentaram aumento significante (p< 0,05) da concentraÃÃo de glicose no testÃculo ipsilateral quando comparada à concentraÃÃo de glicose no testÃculo esquerdo dos mesmos animais nos tempos 0 h e 24h. A diminuiÃÃo do fluxo sangÃÃneo em decorrÃncia da torÃÃo explica a reduÃÃo das concentraÃÃes de ATP e glicose nos testÃculos isquemiados. A ausÃncia de alteraÃÃes nas concentraÃÃes de ATP e glicose nos testÃculos contralaterais (esquerdos) poderia ser uma decorrÃncia do reduzido tempo de isquemia imposto ao testÃculo ipsilateral (direito). Concluiu-se que a torÃÃo testicular unilateral de 720o, por uma hora, induz uma reduÃÃo significante (p < 0,05) das concentraÃÃes testiculares de ATP e de glicose no testÃculo isquemiado sem alteraÃÃes correspondentes da glicemia. A simples manipulaÃÃo do testÃculo direito (cirurgia simulada) induz um aumento da concentraÃÃo de glicose testicular.
Ohlson, Lena. "In vivo studies of cell cycle regulating proteins in rats during liver regeneration and during promotion of liver carcinogenesis /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-980-3/.
Повний текст джерелаSperanzini, Léa Beltrão de Medeiros. "A atividade mioelétrica colônica em ratas sob diferentes estados hormonais: influência de altos níveis de estrógeno, progesterona e da prenhez: estudo experimental in vivo." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5147/tde-06022007-110719/.
Повний текст джерелаThe aim of this study was to find out if the hormonal complex of pregnancy, especially progesterone, could be responsible for decreasing colon myoelectric activity in female rats. We analyzed the records of colon myoelectric activity in vivo using the method of musculoserosal implantation of electrodes in four regions of the colon: proximal ascendent colon, distal ascendent colon, medial colon and descendent colon. The rats were divided in five groups: control, ovariectomized, ovariectomized and treated with estrogen, ovariectomized and treated with progesterone and pregnant rats. The results showed a greater electric activity in the proximal colon in pregnant and progesterone pretreated rats. In pregnant rats the duration of maximum electric activity was significantly greater in all distances studied. The results suggest that in vivo progesterone and the hormonal complex of pregnancy increase myoelectric activity of the proximal colon, and that pregnancy increases the duration of the maximum electric activity of the colon in every distance studied leading to more dehydrated fecal material. Progesterone and pregnancy should not be responsible for colon hypomotility, one of the hypothesis that could explain intestinal constipation in pregnant women
Sinno, Hani. "Role of collagen, complement C3, and C5 on cutaneous wound healing: topical formulation, preparation, and «in-vivo» evaluation in experimental rats." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66713.
Повний текст джерелаLes plaies aigues et chroniques sont associées à des taux de morbidité et mortalité importantes, et c'est pourquoi il est important de réaliser des études approfondies qui permettraient de développer des agents thérapeutiques qui stimulent la guérison de plaie. Le lien entre le système de complément et la guérison de plaies est encore méconnu. Le système de complément est composé de protéines bactéricides et hémolytiques qui augmentent la fuite capillaire tout en stimulant la migration de cellules. Il permet une réaction anaphylactique en recrutant des cellules inflammatoires telles que les fibroblastes suivis par la déposition de collagène au site de la plaie; ensemble celles-ci participent activement à la guérison et sont par la suite modulées par d'autres cellules inflammatoires. Cette étude analyse les effets de l'application topique de collagène, de compléments C3 et C5 sous diverses formes, au site de la plaie. Le modèle expérimental sélectionné a été réalisé par l'application d'une incision chirurgicale sur la peau dorsale du rat. Ces futurs résultats amélioreront notre compréhension de la guérison de plaies tout en permettant le développement d'une approche thérapeutique originale pour le traitement des patients atteints de plaies aigues et chroniques.
Silva, Paula Regina Pereira. "Avaliação do potencial genotóxico e cancerígeno do lodo de estação de tratamento de esgoto (LETE) em sistemas experimentais in vivo." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-13012011-151628/.
Повний текст джерелаFast oxidation of organic matter on tropical soils is another evidence of the great advantage of using biosolids as conditioners once they are able to improve biological, chemical and physical characteristics of the soil with remarkable consequences on agricultural productivity. Therefore, the present project aimed at verifying genotoxic and carcinogenic potential plots of sludge from sewage treatment plants in a pre-defined watershed region at Piracicaba, Capivari and Jundiaí (PCJ1). These data may provide support to evaluate risks on human populations and the environment exposed to sludge from sewage treatment plants. In the study, 140 Wistar male rats, 8 weekold, were used. They were exposed, via chow, to a 10.000 and 50.000 ppm concentration of sludge from sewage treatment plants during 6 to 8 weeks with DEN initiators (diethylnitrosamine) and DMH (1,2-dimethylhydrazine) as mentioned in protocols (Figures 4 and 5). Toxicological evaluation of LETE developed by Center of Evaluation of Environmental Impact on Human Health (TOXICAM) focused toxicological parameters with its genotoxic potential by comet and micronucleus assays on peripheral blood and bone marrow in Wistar rats and carcinogenicity using ACF and AHF assays. Both assays were divided into 4 groups (ACF- GI=Negative Control, GII=Positive Control/DMH III=10.000ppmLETE and GIV=50.000ppmLETE); (AHF-GI=Negative Control, GII=Positive Positive/DEN, GIII=10.000ppmLETE and GIV=50.000ppmLETE). Therefore, on the 3rd week partial hepatectomy was performed in every animal from AHF assays respective groups. assays and to FCA comet test, using MNU (N-methyl-N-nitrosourea) as positive control. The tests in question indicated that the SS not promote increased number of aberrant crypts in the colon, number and area of foci of altered hepatocytes in the liver, lesions in DNA (comet), and also, significantly increased the frequency of micronucleus in cells, according to the following tables 2.1(G=III and IV); 3.1(G=IV); 4(G=,III and IV); 5(G=III,IV and V); 6(G=III,IV and V); 7(G=IV and V). For the positive control. These data may provide support to evaluate risks on human populations and the environment exposed to sludge from sewage treatment plants.
Menezes, Arteiro Queiroz. "Estudo de pulmões de ratos reperfundidos em um modelo experimental ex-vivo: comparação entre duas soluções de preservação (Perfadex® e Celsior®)." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5156/tde-09082013-120744/.
Повний текст джерелаINTRODUCTION: Ischemia-reperfusion injury remaisn the leading cause of mortality related to lung transplantation. Its severity is influenced by several factors including lung preservation. OBJECTIVE: To compare two lung preservation solutions, Perfadex® and Celsior® and its ability to preserve ischemic lung tissue. METHODS: Sixty rat lungs were preserved with Perfadex®, Celsior® or saline after a cold ischemic period of 6 or 12 hours and were then reperfused with homologous blood in an ex vivo experimental model for 60 consecutive minutes. At 10-minute intervals during reperfusion of the heart-lung blocks, data were collected for blood gases, hematocrit, mechanical ventilation, hemodynamic and the heart-lung block weight was recorded. At the end of reperfusion, the left lung was weighed and packaged kept at 70oC for 48h to obtain the wet-to-dry weight ratio. Lung tissue samples were processed for histology, electron microscopy and TUNEL. Statistical analysis included a comparison of the solutions and ischemic times, using ANOVA and Kruskal-Wallis. The significance level was set at 5%. RESULTS: The comparison between the compliance of lungs preserved with Celsior® and Perfadex® in ischemic times of 6 and 12 hours was not statistically significant (p=0.161 and p=0.316, respectively). The lungs subjected to 6 hours of ischemia showed higher lung compliance compared to 12 hours (p=0.02 Perfadex®; Celsior® p=0.019; saline p=0.016). The pulmonary artery pressure values were similar between the three solutions in two stages of ischemia and comparing the times of 6 and 12 hours, regardless of the solution. The Relative Oxygenation Capacity showed no significant difference between the three solutions tested, regardless of the ischemic time. The comparison between the two ischemic times showed that oxygenation capacity was significantly worse in lungs preserved with saline for 12 hours (p=0.001). The wet-to-dry weight ratio showed no statistically significant difference between the three solutions in both ischemic times. However, when ischemic times were compared, Perfadex® showed greater wet-to-dry weight ratio in lungs submitted to 12 hours of ischemia (p=0.001). Light microscopy showed that lungs preserved with saline had more edema than the others, regardless of the ischemic time. Assessment of apoptosis by the TUNEL assay showed no statistically significant difference in the comparison between the groups. CONCLUSIONS: The lungs preserved with Celsior® and Perfadex® performed evenly in regards to gas exchange, hemodynamics and ventilatory mechanics. The lungs preserved with Perfadex® for 12 hours were more edematous. Histopathology findings did not differ between the groups
Cayer, Christian. ""In vivo" Behavorial Characterization of Anxiolytic Botanicals." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20473.
Повний текст джерелаEmmett, C. "Astroglial phenotype in vivo and in vitro." Thesis, University College London (University of London), 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380695.
Повний текст джерелаAmeho, Clement Kojo. "The effect of quercetin as an antioxidant in vivo in rats /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2004.
Знайти повний текст джерелаAdviser: Jeffrey Blumberg. Submitted to the School of Nutrition Science and Policy. Includes bibliographical references. Access restricted to members of the Tufts University community. Also available via the World Wide Web;
Lund, Jacobsen Bodil B. "In vivo investigations of genetically modified microorganisms using germ-free rats /." Roskilde : Roskilde universitet, Department of Life Sciences and Chemistry, 1996. http://hdl.handle.net/1800/460.
Повний текст джерелаHirose, Fumitaka. "In vivo evaluation of retinal injury after transient ischemia in hypertensive rats." Kyoto University, 2006. http://hdl.handle.net/2433/143861.
Повний текст джерелаÖhrvik, Veronica. "Folate bioavailability in vitro experiments and human trials /." Uppsala : Dept. of Food Science, Swedish University of Agricultural Sciences, 2009. http://epsilon.slu.se/200963.pdf.
Повний текст джерелаPhillipson, Mia. "Acid transport through gastric mucus : A study in vivo in rats and mice." Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3368.
Повний текст джерелаThe gastric mucosa is frequently exposed to endogenously secreted hydrochloric acid of high acidity. Gastric mucosal defense mechanisms are arranged at different levels of the gastric mucosa and must work in unison to maintain its integrity.
In this thesis, several mechanisms underlying gastric mucosal resistance to strong acid were investigated in anesthetized rats and mice. The main findings were as follows:
Only when acid secretion occurred did the pH gradient in the mucus gel withstand back-diffusion of luminal acid (100 mM or 155 mM HCl), and keep the juxtamucosal pH (pHjm) neutral. Thus, when no acid secretion occurred and the luminal pH was 0.8-1, the pH gradient was destroyed.
Bicarbonate ions, produced concomitant with hydrogen ions in the parietal cells during acid secretion and blood-borne to the surface epithelium, were carried transepithelially through a DIDS-sensitive transport.
Prostaglandin-dependent bicarbonate secretion seemed to be less important in maintaining a neutral pHjm.
Removal of the loosely adherent mucus layer did not influence the maintenance of the pHjm. Hence, only the firmly adherent mucus gel layer, approximately 80µm thick, seemed to be important for the pHjm.
Staining of the mucus gel with a pH-sensitive dye revealed that secreted acid penetrated the mucus gel from the crypt openings toward the gastric lumen only in restricted paths (channels). One crypt opening was attached to one channel, and the channel was irreversibly formed during acid secretion.
Gastric mucosal blood flow increased on application of strong luminal acid (155 mM HCl). This acid-induced hyperemia involved the inducible but not the neural isoform of nitric oxide synthase. These results suggest a novel role for iNOS in gastric mucosal protection and indicate that iNOS is constitutively expressed in the gastric mucosa.
It is concluded that a pH gradient in the gastric mucus gel can be maintained during ongoing acid secretion, since the acid penetrates the mucus only in restricted channels and bicarbonate is carried from the blood to the lumen via a DIDS-sensitive transporter.
Di, Ciano Patricia. "Changes in in vivo dopamine efflux associated with drug-seeking behaviour by rats." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0031/NQ38877.pdf.
Повний текст джерелаWilson, Lynn Allison 1953. "The effects of early experience on cognitive functioning in the rat." Thesis, The University of Arizona, 1989. http://hdl.handle.net/10150/277046.
Повний текст джерелаChen, Guoyan. "Dielectric characterizations, ex vivo experiments and multiphysics simulations of microwave hyperthermia of biological tissues." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066289/document.
Повний текст джерелаResearch and development of medical devices with various diagnostic and therapeutic applications have been carried out in different countries because of the great advances in electronic and electromagnetic devices during recent decades. However, at present, all of available existing microwave hyperthermia system can just offer treatment, by using high microwave power. In this thesis, a new microwave hyperemia system is researched which could have both diagnostic and therapeutic functions. One single applicator is used to measure dielectric properties of tissue with a very low harmless microwave power for diagnosis first. Then thermal therapeutic treatment will be carried out by using the same applicator with higher and adapted microwave power. Microwave broad band characterization of five different biological tissues at different temperatures with an open–ended coaxial probe method and the virtual line model has been carried out. Ex vivo microwave hyperthermia experiments using microwave power of a few Watts at 2.45GHz have been carried out on five tissues of various thicknesses. Temperature evolution of the biological tissues has been measured by using an infra-red senor. Electromagnetic and thermal simulations for ex vivo microwave hyperthermia experiment have also been achieved by using COMSOL Multiphysics software with 2D axisymmetrical finite–element method and considering different tissues of various thicknesses and incident microwave powers. Simulation results correlate well with the experimental ones. This research, illustrates the possibility to have a flexible and feasible coaxial cable for both diagnosis and treatment for a minimally invasive therapy
Chirrey, Linda Alexandra. "A study of the in vivo metabolism of mitomycin C in tumour tissue." Thesis, University of Strathclyde, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319280.
Повний текст джерелаBertolín, Gálvez Joan. "Terapia génica in vivo para la mucopolisacaridosis tipo iva: estudio de la eficacia en una nueva rata modelo de la enfermedad." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669376.
Повний текст джерелаMucopolysaccharidosis type IVA (MPS IVA) is a lysosomal storage disease caused by the deficiency of the enzyme N-acetylgalactosamine-6-sulfatase (GALNS). The absence of this enzyme leads to the pathological accumulation of glycosaminoglycans (GAG) Keratan Sulfate (KS) and Chondroitin-6-Sulfate. To date, there is no animal model that mimics all the clinical signs of human MPS IVA. Therefore, the main objective of this doctoral thesis was to generate a new MPS IVA rat model introducing the most frequent missense mutation in humans (c.1156C>T) using the CRISPR/Cas9 technology. Then, this model was characterized, which developed the typical signs of the disease, such as alterations in body size, early loss of articular cartilage, chondrocyte hypertrophy, enamel hypoplasia, accumulation of GAGs in multiple organs and a reduction of the survival rate. As there is no treatment capable of reversing all the skeletal alterations of Morquio A patients, the next objective of this doctoral thesis was the development of a new gene therapy approach for the treatment of MPS IVA. To this aim, the biodistribution of an AAV9 vector was studied after intravenous (IV) administration. The results demonstrated a high efficiency of transduction in bones, articular cartilage, teeth, peripheral organs and central nervous system (CNS). Therefore, a gene therapy strategy was developed based on the IV administration of the AAV9-Galns vector. The administration of the therapeutic vector allowed the increase of GALNS activity in serum and in multiple organs. The treatment allowed a recovery of body size and improved the survival rate. An amelioration of growth cartilage was also detected, with a normalization of KS levels, which resulted in a normalization of bone composition and structure. Treatment with AAV9-Galns led to an improvement of joint alterations of MPS IVA rats, which resulted in a normalization of grip strength. The treatment was also able to recover the enamel and improve the dental phenotype of MPS IVA rats. At the peripheral level, the vacuolated cells of the liver, respiratory system and heart were normalized. Regarding the CNS, a normalization of the KS levels and the alterations observed in not treated MPS IVA rats was also observed. Altogether, these results showed that the new MPS IVA rat model presented the main clinical signs of Morquio A. Therefore, the therapeutic efficacy of an IV administration of the AAV9-Galns vector on bone tissue, peripheral organs and the SNC was evaluated in this model. The gene therapy approach described in this work could constitute the preclinical basis for the translation to the clinic of the IV administration of AAV9-Galns in patients of Morquio A.
Gagne, Christine Mona. "The effects of exercise on iron metabolism in adult female rats." Diss., Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/54291.
Повний текст джерелаPh. D.
Shastri, Vineet. "Development of an apparatus to quantify the volitional muscle performance of rat plantar flexors in vivo." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=1958.
Повний текст джерелаTitle from document title page. Document formatted into pages; contains vii, 56 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 48-50).
Fahy, Patricia A. "Ovarian inhibin : in vitro studies using bovine granulosa cells and in vivo studies in rats." Thesis, University of Reading, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309518.
Повний текст джерелаPitcher, Toni Leigh, and n/a. "In vivo electrophysiology of striatal spiny projection neurons in the spontaneously hypertensive rat (SHR)." University of Otago. Department of Anatomy & Structural Biology, 2007. http://adt.otago.ac.nz./public/adt-NZDU20070321.114819.
Повний текст джерела陳世安 and Sai-on Chan. "In vivo and in vitro studies on the regulation of C-KI-RAS expression in liver." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1992. http://hub.hku.hk/bib/B30251813.
Повний текст джерелаSilva, Paulo Eduardo da. "Efeitos do protocolo de estressores em ratos submetidos a um regime contínuo de privação de água." Pontifícia Universidade Católica de São Paulo, 2015. https://tede2.pucsp.br/handle/handle/16753.
Повний текст джерелаCoordenação de Aperfeiçoamento de Pessoal de Nível Superior
The Chronic Mild Stress (CMS) has been described in the literature as an experimental model of anhedonia, central symptom of depression in humans. The anhedonia has been studied in this model looking for a decrease of water with sucrose consumption in rats. This result is usually observed after the animal had been subjected to a set of stressful stimuli in a moderated and chronical way, for six weeks in average. The present study aimed to investigate the effects of the Stressors Protocol in rats subjected to a continuous water deprivation regimen. Eleven male rats of Wistar lineage were studie,. All the rats were subjected to a water deprivation schedule until reaching 85% of their ad lib weights, and they were maintained at these weights for the whole study. Thirteen water and water with sucrose consumption tests were used for all the subjects, while S7 was exposed only to the liquids consumption tests. S3 subject was submitted only to the Stressors Protocol. S5 was exposed to the same conditions of S3, except that the Stressors Protocol involved only the grouping stressor. For the other eight subjects, first they had the bar press response to the two bars modeled, using water as reinforcement. Then these eight animals were subjected to a Conc VI 5 sec VI 5 sec reinforcement, each bar being associated to water or water with sucrose reinforcements (one for each bar). After four weeks in this reinforcement schedule these animals were subjected to the Stressors Protocol for six consecutive and uninterrupted weeks in their living cages. During the protocol, four subjects (S2, S6, S8 and S10) also had their bar press responses reinforced in a Conc VI 5 sec VI 5 sec schedule (group before, during and after). The other four rats (S1, S4, S9 and S11- group before and after) were not submitted to operant sessions as long as the Stressors Protocol was available. At the end of the phase when the Stressors Protocol was available, these eight subjects were again subjected to the base line condition. The main results were: (a) a weight stability for the animals subjected to the protocol, (b) a high alternation of water and water with sucrose consumption in the tests for the only subject submitted to the tests and to the protocol, not demonstrating anhedonia, (c) a reduction in the animal s food consumption and an increase of water consumption in the living cage during the protocol for seven subjects, (d) the stressors protocol was not followed by a modification of the distribution of water and water with sucrose reinforced responses by Conc VI 5sVI5s, neither during the protocol, nor after its cessation, and (e) it seems that the reinforcement value of the liquids alternated for some subjects over major of the sessions. The role of continuous water deprivation and the measures used as anhedonia indicators are discussed
O Chronic Mild Stress (CMS) tem sido descrito na literatura como um modelo experimental de anedonia, sintoma central na depressão em humanos. A anedonia tem sido estudada dentro desse modelo a partir do decréscimo no consumo de água com sacarose em ratos. Este resultado é geralmente observado após o animal ser submetido a um conjunto de estímulos estressores de forma moderada e crônica, durante seis semanas em média, O presente estudo teve como objetivo investigar os efeitos do Protocolo de Estressores em ratos submetidos a um regime contínuo de privação de água. Foram empregados 11 ratos machos, da linhagem Wistar. Todos os sujeitos foram submetidos a um esquema de privação de água até atingir 85% dos seus pesos ad lib. e foram mantidos nesses pesos durante todo o estudo. Foram empregados 13 testes de consumo de água e de água com sacarose, sendo que o Sujeito S7 só passou pelos testes de consumo dos líquidos. O Sujeito S3 foi submetido ao Protocolo de Estressores. O sujeito S5 passou pelas mesmas condições que o S3, exceto que o Protocolo de Estressores envolveu apenas o estressor agrupamento. Para os outros 8 sujeitos, primeiramente foram modeladas as respostas de pressão às duas barras, usando água como reforçador. Depois, esses 8 animais foram submetidos a um esquema Conc VI 5 seg VI 5 seg associado aos reforços água e água com sacarose (um para cada barra). Após quatro semanas nesse esquema de reforçamento esses animais foram submetidos ao Protocolo de Estressores por seis semanas consecutivas e ininterruptas nas suas gaiolas-viveiro. Durante o Protocolo, 4 sujeitos (S2, S6, S8, S10) também tiveram suas respostas de pressão à barra reforçadas num esquema Conc VI 5 seg VI 5 seg (grupo antes, durante e depois) e os outros 4 (S1, S4, S9, S11) não (grupo antes e depois). Ao término do Protocolo de estressores, esses 8 sujeitos foram submetidos novamente à condição de linha de base. Os principais resultados encontrados foram: (a) estabilidade nos pesos dos animais submetidos ao protocolo, (b) maior oscilação em relação ao consumo de água e de água com sacarose para o sujeito submetido apenas aos testes e ao protocolo, não demonstrando anedonia, (c) redução no consumo de ração e aumento no consumo de água na gaiola-viveiro durante o protocolo (d) o protocolo de estressores não foi acompanhada por uma alteração na distribuição de respostas reforçadas com água e água com sacarose, nem durante e nem após a suspensão do mesmo, e (e) o valor reforçador dos líquidos parece ter se alternado para alguns sujeitos ao longo da maioria das sessões. Discute-se o papel da privação contínua de água e as medidas utilizadas como indicativas a de anedonia
Persson, Kirstin Gracia. "In vivo effects of crinum macowanii on the rat cardiovascular system." Thesis, University of the Western Cape, 2007. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_4721_1222073945.
Повний текст джерелаCrinum macowanii (C. macowanii) (Amaryllidacea) as authenticated by Mr. F. Weitz at the Herbarium, University of the Western cape, is widely used a traditional remedy and is thought to have therapeutic value (Fennell and van Staden 2001). The objective of this study was to determine the cardiovascular effects of the crude aqueous extract of Crinum macowanii on the rat and to determine the effect of pre-treatment drugs on Crinum macowanii in in vivo, anaesthetized normotensive, male Wistar rats (200-250 g.).
Cournil-Henrionnet, Christel. "Potentialités chondroprotectrices d'Hsp70 vis à vis des phénomènes apoptotiques : Etudes in vitro et in vivo chez le rat." Nancy 1, 2003. http://www.theses.fr/2003NAN12504.
Повний текст джерелаPetekkaya, Ali Tolga. "In Vivo Indenter Experiments On Soft Biological Tissues For Identification Of Material Models And Corresponding Parameters." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12610071/index.pdf.
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s) effect and anisotropic response were examined. By using the results of the relaxation and creep tests, parameters of the Prony series capable of modelling these data were determined. With this study, some important conclusions regarding the soft biological tissues were drawn and thus the behaviors of the soft biological tissues were better understood. Besides, the difficulties inherent to in-vivo tests were recognized and actions to reduce these difficulties were explained. Finally, clean experimental data, to be used in the computer simulations, were obtained.
Ström, Jakob, Edvin Ingberg, Annette Theodorsson, and Elvar Theodorsson. "Method parameters’ impact on mortality and variability in rat stroke experiments : a meta-analysis." Linköpings universitet, Klinisk kemi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-93981.
Повний текст джерелаFunding Agencies|County Council of Ostergotland, Sweden||
Lee, Chun-kei, and 李鎮基. "Development of an in vivo animal model for testing of endodontic medicaments on pulp tissue." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31954182.
Повний текст джерелаLee, Chun-kei. "Development of an in vivo animal model for testing of endodontic medicaments on pulp tissue." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk:8888/cgi-bin/hkuto%5Ftoc%5Fpdf?B23300462.
Повний текст джерелаGraves, S., C. Lewis, H. Valdovinos, B. Bednarz, W. Cai, T. Barnhart, and R. Nickles. "In vivo cell tracking with 52Mn PET: Targetry, Separation, and Applications." Helmholtz-Zentrum Dresden - Rossendorf, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-166432.
Повний текст джерелаJeannin, Jean-François. "Modifications par les endotoxines de l'effet des macrophages sur les cellules cancéreuses intestinales de rat : Etude in vitro et in vivo." Dijon, 1985. http://www.theses.fr/1985DIJOS049.
Повний текст джерелаZhou, Xin. "In silico investigations into human ventricular pro-arrhythmic mechanisms combined with in vivo and in vitro experiments." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:b36acc5e-d6d6-4369-b0a4-3a868b5fcf0f.
Повний текст джерелаMissy, Pascale Burnel Daniel. "Recherche de nouveaux chélateurs du manganèse, en vue de la détoxication de l'organisme Etude in vivo et in vitro chez le rat /." [S.l.] : [s.n.], 2001. ftp://ftp.scd.univ-metz.fr/pub/Theses/2001/Missy.Pascale.SMZ0123.pdf.
Повний текст джерелаLee, Jennifer S. C. "The in vivo effects of BaP:DMBA and resveratrol on the bone and the ovary of young rats." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63100.pdf.
Повний текст джерелаCherkaoui-Malki, Mustapha. "Contribution à l'étude du mécanisme d'action des proliférateurs de péroxysomes au niveau post-traductionnel et post-transcriptionnel dans les cellules hépatiques de rats traités in vivo." Besançon, 1991. http://www.theses.fr/1991BESA2047.
Повний текст джерелаPodwojewski, Florence. "Caractérisation biomécanique globale de la paroi abdominale saine, lésée et réparée : de l’ex vivo à l’in vivo." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10270.
Повний текст джерелаData on the biomechanical behaviour of the abdominal wall are limited. This lack of knowledge is a limiting factor for the development of numerical models of this anatomical area. Therefore, the objective of this thesis is to provide quantitative data on the biomechanical behaviour of the abdominal wall, adopting a global experimental approach ranging from ex vivo to in vivo. As a first step, a protocol for ex vivo characterization is develop and validated on porcine specimens and then applied to human anatomical specimens. This protocol allows testing a same abdominal wall under two loading types (pressure and contact) in the elastic range. It also enables to assess the influence of an incision and of a repair with a surgical implant on the mechanical response. Measurements by 3D digital image correlation performed simultaneously on the internal and external surfaces quantify differences in strain distribution of the abdominal wall. As a second step, in vivo examinations on volunteers enable to take into account muscle activity. A local stiffness is thus assessed for various physiological activities. This stiffness increases with the level of muscle contraction and reaches on average six times the stiffness at rest. In conclusion, this research proposes a methodology to better understand the global mechanical behaviour of the abdominal wall. This methodology can now be used in order to study the influence of the different components of the abdominal wall. Beyond this thesis, these data will contribute to the construction and validation of a numerical model of the abdominal wall
Broussolle, Emmanuel. "Effet d'un activateur noradénergique, dopaminergique, et cholinergique central, le RU 24722, sur la consommation cérébrale locale de glucose mesurée in vivo chez le rat." Lyon 1, 1985. http://www.theses.fr/1985LYO10279.
Повний текст джерелаCunat, Lisiane Burnel Daniel. "BIODISPONIBILITE DE L'ALUMINIUM DANS L'INTESTIN. ETUDES IN VITRO ET IN VIVO CHEZ LE RAT /." [S.l.] : [s.n.], 1999. ftp://ftp.scd.univ-metz.fr/pub/Theses/1999/Cunat.Lisiane.SMZ9931.pdf.
Повний текст джерелаMerchant, S. J. "Experiments in anaesthetised rats to determine the role of acetylcholine in the release of noradrenaline from the cervical sympathetic nerve." Thesis, University of Leeds, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381280.
Повний текст джерелаSantoro, Davide. "Optimisation of indirect detected ¹³C spectroscopy and micro-imaging experiments for in vivo applications in plants." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407096.
Повний текст джерелаLeding, Albin. "Optimized design recommendation for first pharmacokinetic in vivo experiments for new tuberculosis drugs using pharmacometrics modelling and simulation." Thesis, Uppsala universitet, Institutionen för farmaci, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447311.
Повний текст джерела唐國華 and Guohua Tang. "Growth modification of the rat's mandibular condyle by functional appliances: a cellular and molecular study." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31245997.
Повний текст джерелаHussenet, Marie-Pierre. "Influence de la monensine sur l'absorption de l'acide oléique "In Vitro" et "In Vivo" chez le rat." Dijon, 1990. http://www.theses.fr/1990DIJOS046.
Повний текст джерелаGeronilla, Kenneth B. "The quantification of oscillatory force parameters that affect eccentric contraction induced injury in an in vivo rodent." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=1851.
Повний текст джерелаTitle from document title page. Document formatted into pages; contains vii, 65 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 59-62).
Oliveira, Elizabeth Maria Costa de. "Avaliação funcional, in vitro e in vivo, de ilhotas pancreáticas humanas nuas e microencapsuladas." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-22012015-165806/.
Повний текст джерелаType 1 diabetes mellitus results from insufficient or absence of insulin production, as a consequence of destruction of pancreatic β cells, by an auto-imune mechanism. Treatment for this type of diabetes consists of subcutaneous administration of exogenous insulin. Recently, it has been demonstrated that pancreatic islet cell transplantation is capable of rendering type I diabetic patients independent of exogenous insulin. However, in spite of the success achieved, permanent immunosuppression is still required, being the main barrier to expand this treatment to a large number of patients. Therefore, development of new technologies, such as islet macro and microencapsulation to avoid rejection of the tissue implanted, is still crucial for definitive establishment of islet transplantation as a therapeutic alternative for type I diabetes. In the present work, an animal model was established for in vivo evaluation of the functional ability of human pancreatic islets, which were isolated and purified at the Human Pancreatic Islet Unit of the University of São Paulo Chemistry Institute. Diabetes was induced in NIH nude rats through streptozotocin injection followed by implantation of naked or microencapsulated human pancreatic islets. Biodritin, a new and patented heteropolyssaccaride was used to microencapsulate the islets. The production of uniform and homogeneous microcapsules with diameters in the range of 400µm e 600 µm was successfully established. Reversion of diabetes occurred in 24% of the nude rats transplanted with human pancreatic islets. On the other hand, no reversion of diabetes was observed when encapsulated islets were implanted, although their functional activity in vitro indicated that they secreted insulin and responded to glucose stimulation upon encapsulation. In order to elucidate this effect, empty capsules were implanted in nude rat and in immunocompetent rats, both of which developed an inflammatory process accompanied by a fibrotic process in the site of the implant. Immunohistochemical studies are underway to address the nature and the intensity of these inflammatory processes.
Henriksnäs, Johanna. "Helicobacter pylori and Gastric Protection Mechanisms : An in vivo Study in Mice and Rats." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5898.
Повний текст джерелаRajikan, Roslee. "Absorption and metabolism of [2-¹â´C]quercetin-4'-glucoside in rats ex vivo and in vitro." Thesis, University of Glasgow, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433111.
Повний текст джерелаKallincos, Nicholas Campbell. "Growth hormone (GH) and insulin-like growth factor-I (IGF-I) in vivo: investigation via transgenesis in rats /." Adelaide : Thesis (Ph.D.) -- University of Adelaide, Department of Biochemistry, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phk143.pdf.
Повний текст джерелаKallincos, Nicholas Campbell. "Growth hormone (GH) and insulin-like growth factor-I (IGF-I) in vivo: investigation via transgenesis in rats." Thesis, Adelaide, 1993. http://hdl.handle.net/2440/21602.
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