Готові списки джерел за темами / Immunoregulatory properties and inflammation

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Добірка наукової літератури з теми "Immunoregulatory properties and inflammation"

Автор: Grafiati

Опубліковано: 11 березня 2023

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Статті в журналах з теми "Immunoregulatory properties and inflammation"

Nie, Hong. "Novel immunoregulatory properties of EGCG on reducing inflammation in EAE." Frontiers in Bioscience 18, no. 1 (2013): 332. http://dx.doi.org/10.2741/4104.

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Petrovsky, F. I., Yu A. Petrovskaya, L. M. Ogorodova, and V. Yu Serebrov. "Cytokines and nitric oxide in case of bronchial asthma." Bulletin of Siberian Medicine 1, no. 1 (March 30, 2002): 70–74. http://dx.doi.org/10.20538/1682-0363-2002-1-70-74.

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Complex interactions between nitric oxide and cytokines of atopic inflammation are presented. The effects of interleukin-4 on nitric oxide synthesis, immunoregulatory properties of nitric oxide and its influence on Th1/Th2 balance are described.

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Semenkov, N. N., V. S. Gorin, S. G. Zhabin, L. V. Renge, and N. G. Potekhin. "Inhibitors of proteolysis and plasminogen of blood serum in parturient women with an uncomplicated course of the postpartum period." Kazan medical journal 79, no. 2 (March 25, 1998): 135–36. http://dx.doi.org/10.17816/kazmj63776.

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Recent studies have shown that proteolysis inhibitors can be regarded as markers of inflammation with immunoregulatory properties. From this point of view, the study of inhibitors of proteinases in blood serum of puerperas with an uncomplicated course of the postpartum period is of great scientific and practical interest.

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Shi, Chenchen, Haipeng Li, Yifu Yang, and Lifei Hou. "Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives." Mediators of Inflammation 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/435713.

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Artemisinin and its derivatives are widely used in the world as the first-line antimalarial drug. Recently, growing evidences reveal that artemisinin and its derivatives also possess potent anti-inflammatory and immunoregulatory properties. Meanwhile, researchers around the world are still exploring the unknown bioactivities of artemisinin derivatives. In this review, we provide a comprehensive discussion on recent advances of artemisinin derivatives affecting inflammation and autoimmunity, the underlying molecular mechanisms, and also drug development of artemisinins beyond antimalarial functions.

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Harrell, Carl Randall, Vladislav Volarevic, Valentin Djonov, and Ana Volarevic. "Therapeutic Potential of Exosomes Derived from Adipose Tissue-Sourced Mesenchymal Stem Cells in the Treatment of Neural and Retinal Diseases." International Journal of Molecular Sciences 23, no. 9 (April 19, 2022): 4487. http://dx.doi.org/10.3390/ijms23094487.

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Therapeutic agents that are able to prevent or attenuate inflammation and ischemia-induced injury of neural and retinal cells could be used for the treatment of neural and retinal diseases. Exosomes derived from adipose tissue-sourced mesenchymal stem cells (AT-MSC-Exos) are extracellular vesicles that contain neurotrophins, immunoregulatory and angio-modulatory factors secreted by their parental cells. AT-MSC-Exos are enriched with bioactive molecules (microRNAs (miRNAs), enzymes, cytokines, chemokines, immunoregulatory, trophic, and growth factors), that alleviate inflammation and promote the survival of injured cells in neural and retinal tissues. Due to the nano-sized dimension and bilayer lipid envelope, AT-MSC-Exos easily bypass blood–brain and blood–retinal barriers and deliver their cargo directly into the target cells. Accordingly, a large number of experimental studies demonstrated the beneficial effects of AT-MSC-Exos in the treatment of neural and retinal diseases. By delivering neurotrophins, AT-MSC-Exos prevent apoptosis of injured neurons and retinal cells and promote neuritogenesis. AT-MSC-Exos alleviate inflammation in the injured brain, spinal cord, and retinas by delivering immunoregulatory factors in immune cells, suppressing their inflammatory properties. AT-MSC-Exos may act as biological mediators that deliver pro-angiogenic miRNAs in endothelial cells, enabling re-vascularization of ischemic neural and retinal tissues. Herewith, we summarized current knowledge about molecular mechanisms which were responsible for the beneficial effects of AT-MSC-Exos in the treatment of neural and retinal diseases, emphasizing their therapeutic potential in neurology and ophthalmology.

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Dasgupta, Suryasarathi, Deniz Erturk-Hasdemir, and Dennis Kasper. "Characterization of a DC Presenting a Microbial Polysaccharide to Regulatory T cells. (49.9)." Journal of Immunology 188, no. 1_Supplement (May 1, 2012): 49.9. http://dx.doi.org/10.4049/jimmunol.188.supp.49.9.

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Abstract Bacteroides fragilis Polysaccharide A (PSA) is a unique commensal microflora molecule which has shown potent CD4+T cell mediated IL-10 dependent anti-inflammatory properties in various murine models. Little is known about how these immunoregulatory T cells are induced in order to control inflammation. We first observed that PSA dependent augmentation of regulatory T cells correlated with frequency of B220+CD11cint cells in MLN. We focused majorly on Plasmacytoid dendritic cells (PDCs), which have been implicated as tolerogenic DCs in other inflammatory situations. We observed higher expression of TLR2, a previously reported PSA receptor, in PSA treated PDCs compared to media control in vitro. Isolated PDCs from wild type compared to TLR2 deficient PDCs significantly augmented the liberation of IL-10 from CD4T cells in presence of PSA (p=0.0046), a process mediated by co-stimulators ICOSL and CD86. In a TNBS induced colonic inflammation model to study PSA mediated protection, the frequency of PDCs correlated significantly but inversely with cumulative colitis score (R2=0.4377, p=0.0002) suggesting an immunoregulatory role of these cells. Interestingly, neither protection nor change in PDCs was observed in TLR2-/-mice. In addition, PSA failed to protect mice when either PDCs were depleted or co-stimulators inhibited in vivo with monoclonal antibodies. This work suggests a tolerogenic or immunoregulatory role for PDCs most probably by generating regulatory features in T cells.

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Nair, Meera G., Yurong Du, Jacqueline G. Perrigoue, Colby Zaph, Justin J. Taylor, Michael Goldschmidt, Gary P. Swain та ін. "Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung". Journal of Experimental Medicine 206, № 4 (6 квітня 2009): 937–52. http://dx.doi.org/10.1084/jem.20082048.

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Differentiation and recruitment of alternatively activated macrophages (AAMacs) are hallmarks of several inflammatory conditions associated with infection, allergy, diabetes, and cancer. AAMacs are defined by the expression of Arginase 1, chitinase-like molecules, and resistin-like molecule (RELM) α/FIZZ1; however, the influence of these molecules on the development, progression, or resolution of inflammatory diseases is unknown. We describe the generation of RELM-α–deficient (Retnla−/−) mice and use a model of T helper type 2 (Th2) cytokine-dependent lung inflammation to identify an immunoregulatory role for RELM-α. After challenge with Schistosoma mansoni (Sm) eggs, Retnla−/− mice developed exacerbated lung inflammation compared with their wild-type counterparts, characterized by excessive pulmonary vascularization, increased size of egg-induced granulomas, and elevated fibrosis. Associated with increased disease severity, Sm egg–challenged Retnla−/− mice exhibited elevated expression of pathogen-specific CD4+ T cell–derived Th2 cytokines. Consistent with immunoregulatory properties, recombinant RELM-α could bind to macrophages and effector CD4+ Th2 cells and inhibited Th2 cytokine production in a Bruton's tyrosine kinase–dependent manner. Additionally, Retnla−/− AAMacs promoted exaggerated antigen-specific Th2 cell differentiation. Collectively, these data identify a previously unrecognized role for AAMac-derived RELM-α in limiting the pathogenesis of Th2 cytokine-mediated pulmonary inflammation, in part through the regulation of CD4+ T cell responses.

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Wongchitrat, Prapimpun, Mayuri Shukla, Ramaswamy Sharma, Piyarat Govitrapong, and Russel J. Reiter. "Role of Melatonin on Virus-Induced Neuropathogenesis—A Concomitant Therapeutic Strategy to Understand SARS-CoV-2 Infection." Antioxidants 10, no. 1 (January 2, 2021): 47. http://dx.doi.org/10.3390/antiox10010047.

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Viral infections may cause neurological disorders by directly inducing oxidative stress and interrupting immune system function, both of which contribute to neuronal death. Several reports have described the neurological manifestations in Covid-19 patients where, in severe cases of the infection, brain inflammation and encephalitis are common. Recently, extensive research-based studies have revealed and acknowledged the clinical and preventive roles of melatonin in some viral diseases. Melatonin has been shown to have antiviral properties against several viral infections which are accompanied by neurological symptoms. The beneficial properties of melatonin relate to its properties as a potent antioxidant, anti-inflammatory, and immunoregulatory molecule and its neuroprotective effects. In this review, what is known about the therapeutic role of melatonin in virus-induced neuropathogenesis is summarized and discussed.

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Tilg, Herbert, and Arthur Kaser. "Interferons and Their Role in Inflammation." Current Pharmaceutical Design 5, no. 10 (October 1999): 771–85. http://dx.doi.org/10.2174/1381612805666230111210939.

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Cytokines are pleiotropic molecules showing a wide variety of biologic functions on various cells and tissues, and several different cytokines exert similar and overlapping functions on certain cells. Interferons (IFNs), among the first cytokines identified, play a crucial role in human disease. The IFN cytokine family consists of type I IFNs (IFN-a and IFN- ) and type II IFN (IFN-y). In the first decades of IFN research, type I IFNs were considered primarily as viral inhibitors, whereas type II IFN, also termed "immune IFN", was generally considered to be uniquely involved in immune reactions. This view has changed considerably in the last years. The importance of type I IFNs in inflammation, immunoregulation and T-cell responses has been identified and has changed dramatically our interpretation of the biological relevance of type I and II IFNs. Recent data suggest that IFN-a is a multifunctional immunomodulatory cytokine with profound effects on the cytokine cascade including several anti-inflammatory properties, whereas IFN-y remains a classical proinflammatory cytokine. These different effects on critical mediators of inflammation may also explain why type I and II IFNs are clinically successful in different diseases. These newly identified immunoregulatory and anti-inflammatory functions of type I IFNs may be of importance in the treatment of diseases such as chronic viral hepatitis or multiple sclerosis and help to explain some of the mechanisms of IFNs.

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Morianos, Ioannis, and Maria Semitekolou. "Dendritic Cells: Critical Regulators of Allergic Asthma." International Journal of Molecular Sciences 21, no. 21 (October 26, 2020): 7930. http://dx.doi.org/10.3390/ijms21217930.

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Allergic asthma is a chronic inflammatory disease of the airways characterized by airway hyperresponsiveness (AHR), chronic airway inflammation, and excessive T helper (Th) type 2 immune responses against harmless airborne allergens. Dendritic cells (DCs) represent the most potent antigen-presenting cells of the immune system that act as a bridge between innate and adaptive immunity. Pertinent to allergic asthma, distinct DC subsets are known to play a central role in initiating and maintaining allergen driven Th2 immune responses in the airways. Nevertheless, seminal studies have demonstrated that DCs can also restrain excessive asthmatic responses and thus contribute to the resolution of allergic airway inflammation and the maintenance of pulmonary tolerance. Notably, the transfer of tolerogenic DCs in vivo suppresses Th2 allergic responses and protects or even reverses established allergic airway inflammation. Thus, the identification of novel DC subsets that possess immunoregulatory properties and can efficiently control aberrant asthmatic responses is critical for the re-establishment of tolerance and the amelioration of the asthmatic disease phenotype.

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Дисертації з теми "Immunoregulatory properties and inflammation"

Alder, Louise B. A. "Immunoregulatory properties of polyclonal immunoglobulin for therapeutic use." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361937.

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Wongjindanon, Nuttapong. "Immunoregulatory properties of MPO and pathophysiology of its autoantibodies." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621380.

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Khademi, Mohsen. "Characterization and modulation of immunoregulatory molecules in neuroinflammation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-006-0/.

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Matsubara, Yasushi. "Delineation of immunoregulatory properties of adult T cell leukemia cells." Kyoto University, 2007. http://hdl.handle.net/2433/135653.

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Schneider, Enja [Verfasser]. "The immunoregulatory role of T cell-derived CD73 in the context of inflammation / Enja Schneider." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/1229387374/34.

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Van, Oers Nicolai S. C. (Nicolai Stanislas Cyrille). "Biochemical and immunoregulatory properties of a distincte murine alpha-fetoprotein isoform." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74568.

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Alpha-fetoprotein (AFP) is a tumor-associated embryonic serum glycoprotein, existing in the circulation as a heterogeneous population of closely related molecular variants. The biological function(s) of AFP is not known, but the precisely regulated expression of AFP molecules during ontogenetic development and in certain diseases is consistent with an immunoregulatory function.
The present thesis examines the functional significance of murine AFP microheterogeneity. In the initial phase of this study, seven individual AFP isoforms were purified with a novel separation protocol developed on Mono Q anion-exchange columns linked to an FPLC system. All seven subspecies were further characterized by isoelectric focusing gels, immunoblot analysis, molecular weight determination, and sialic acid composition studies. When all seven variants were tested in several AFP sensitive immune assays, we determined that all the immunosuppressive activity of native AFP was localized to a single distinct molecular variant. This isoform, AFP-1, exhibited an isoelectric point of pH = 5.1, contained 1 mol of sialic acid/mol of protein, and represented approximately 6% of the total population of naturally occurring AFP isoforms isolated from the amniotic fluid at days 15-19 of murine gestation. Further studies indicated that sialic acid expression on the carbohydrate portion of the AFP molecules was unlikely to be involved in the suppressor function.
Since it has been reported that the polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid complexed to AFP molecules may be necessary for the expression of AFP-mediated immunoregulatory activity, we also examined the potential contribution of these polyunsaturated fatty acids to the immunoregulative function of the active isoform. Gas liquid chromatographic analyses, delipidation procedures and fatty acid reassociation experiments indicated that these fatty acids are unlikely to contribute to AFP-mediated immunosuppressive activity. We also determined that MAF-derived AFP from different gestational time points including days 10.5, 12.5, 14.5, 16.5, and 18.5 exhibits immunosuppressive activity in vitro. All the above results are the first direct demonstration that individual molecular variants of murine AFP have distinct immunoregulatory properties. This should facilitate a better comprehension of the relationship of molecular structure to biological function of AFP molecules during fetal development.

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Kaur, Komal Amandeep. "The Immunoregulatory Role of Natural Killer (NK) Cell Derived IL-10 During Microbial Infections." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31353.

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Natural Killer (NK) cells, lymphocytes of the innate immune response, play a vital role in controlling infections and in tumor surveillance. NK cells provide protection by direct cytolysis of infected cells and by the production of pro-inflammatory cytokines such as, IFN-γ and TNF-α. Notably, NK cells have recently been identified to regulate the immune response by producing the anti-inflammatory cytokine IL-10. Several other cells can produce IL-10 during infections, however NK cell derived IL-10 can be critical in regulating immune response during early phases of infection and therefore protecting the host from excessive immunopathology. Although the regulatory role of NK cells seems to be plausible, the physiological relevance of NK cell mediated immune regulation during infections has not been demonstrated in detail. To investigate the immunoregulatory function of NK cells, I used Murine Cytomegalovirus (MCMV) infection induced by a high dose challenge and demonstrated that NK cells are a major IL-10 producer during acute stage of the infection. To elucidate the role of NK cell derived IL-10 during infections, I generated NK cell specific IL-10 knockout, NKp46iCre  Il-10flox/flox mice (NK-Il-10-/-) by crossing Il-10flox/flox mice with mice expressing Cre recombinase exclusively under the NK cell specific promoter, NKp46 (NKp46iCre knock-in mice). My results indicated that Cre mediated Il-10 genomic deletion occurred predominantly in NK cells but not in NKT, T and B cells. Enriched NK cells from NK-Il-10-/- mice failed to produce IL-10 upon ex vivo IL-2/IL-12 stimulation. Furthermore, histological analysis of the colon indicated that NK-Il-10-/- mice are free from aberrant inflammation. During sustained MCMV infection, significantly higher production of IFN-γ by CD8+ T cells of NK-Il-10-/- mice in salivary glands indicates that NK cell derived IL-10 contributes to the establishment of the immune suppressive environment in the organ. NK-Il-10-/- mice also demonstrated increased susceptibility to acute Listeria monocytogenes (LM) infection based on enhanced body weight loss. Taken together, I have successfully generated NK-Il-10-/- mice that lack the Il-10 gene exclusively in NK cells. The NK-Il-10-/- mouse can be used as an ideal model to dissect the immunoregulatory role of NK cells during various microbial infections and tumorogenesis.

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Lin, Jiaying [Verfasser]. "Immunoregulatory properties of cancer stem-like cells derived from carcinoma cell lines of the cervix uteri / Jiaying Lin." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2014. http://d-nb.info/1052530338/34.

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Amarakoon, A. M. T. "Studies on the antioxidant activity and immunomodulatory properties of black tea." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241795.

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Hotchkiss, Kelly M. "Engineering Surface Properties to Modulate Inflammation and Stem Cell Recruitment through Macrophage Activation." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5492.

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Biomaterials are becoming the most commonly used therapeutic method for treatment of lost or damaged tissue in the body. Metallic materials are chosen for high strength orthopaedic and dental applications. Titanium (Ti) implants are highly successful in young, healthy patients with the ability to fully integrate to surrounding tissue. However the main population requiring these corrective treatments will not be healthy or young, therefore further research into material modifications have been started to improve outcomes in compromised patients. The body’s immune system will generate a response to any implanted material, and control the final outcome. Among the first and most influential, cells to interact with the implant will be macrophages. Throughout this study we have 1) established the ability of macrophages to recognize and differentially activate in response to material surface properties, 2) investigated the role of integrin binding in macrophage activation to material properties, and 3) confirmed the importance of macrophage activation in vivo following Ti implant placement. The generation of a hydrophilic implant surface promoted the greatest anti-inflammatory and pro-regenerative macrophage activation. Surface wettability will control protein adsorption which can activated different integrin binding on macrophages and may be responsible for changes in activation. When integrin β3 subunit binding was prevented hydrophilic surfaces no longer promoted an anti-inflammatory macrophage activation. Additionally, when macrophage levels were reduced using two separate ablation models, MaFIA mice and clodronate liposomes, hydrophilic surfaces no longer promoted anti-inflammatory T-cell populations and cytokine profiles. There were also fewer stem cells adhered to implant surfaces at 1, 3, and 7 days when macrophage populations were compromised.

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Книги з теми "Immunoregulatory properties and inflammation"

Dupuis, Nina, and Stéphane Auvin. Anti-Inflammatory Effects of a Ketogenic Diet. Edited by Jong M. Rho. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0017.

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The high-fat, low-carbohydrate ketogenic diet (KD) is an established and proven treatment for pharmacoresistant epilepsy. Recently, the KD is being explored for some inflammation-induced epileptic encephalopathies. Given the broad neuroprotective properties of the KD in various experimental models of neurological disorders, there are yet additional potential future uses. Consistent with this, there is growing evidence that the KD exerts anti-inflammatory activity. Ketone bodies, caloric restriction, and polyunsaturated fatty acids might be involved in the modulation of inflammation by the KD. This chapter reviews the evidence that, in part through anti-inflammatory effects, the KD holds promise in the treatment of certain epileptic disorders, neuropathic pain, multiple sclerosis, and Parkinson’s disease.

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Sabharwal, Nikant, Parthiban Arumugam, and Andrew Kelion. Cardiac positron emission tomography (PET). Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198759942.003.0012.

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As in single photon emission computed tomography (SPECT), positron emission tomography (PET) involves the injection of a radiopharmaceutical, the physiological properties of which determine its distribution within the patient. The labelling radionuclide then allows this distribution to be imaged. The value of cardiac PET as a routine clinical tool, particularly for perfusion imaging, was previously limited by the expense and scarcity of cameras and the short half-lives of the radionuclides with complex radiochemistry. The need for an on-site cyclotron to produce these radiopharmaceuticals made a clinical service non-viable. A number of recent developments, however, have led to renewed interest in cardiac PET. This chapter covers PET instrumentation, detail on the radiopharmaceuticals used in cardiac PET, and a number of sections on F-fluorodeoxyglucose (F-FDG) PET covering infection and inflammation imaging.

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Speer, Thimoteus, and Danilo Fliser. Abnormal endothelial vasomotor and secretory function. Edited by David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0113.

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The endothelium plays a crucial role in the maintenance of vascular integrity and function. Nitric oxide produced by endothelial cells is a key player, inducing relaxation of vascular smooth muscle cells, inhibition of vascular inflammation, and prevention of coagulatory activation. Chronic kidney disease (CKD) is characterized by deterioration of different protective endothelial properties, collectively described as endothelial dysfunction. Several factors such as methylarginines, modified lipoproteins, and other substances that accumulate may be involved in the pathogenesis of endothelial dysfunction of CKD. Endothelial dysfunction is suggested to be the first critical step in the initiation of atherosclerosis. Clinical assessment of endothelial function may become important in recognition of patients with increased cardiovascular risk. Beside several invasive and non-invasive methods to assess endothelial function in vivo, measurement of circulating (bio)markers may be useful for the evaluation of endothelial dysfunction.

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Mason, Peggy. Somatosensation. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190237493.003.0017.

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Under normal circumstances, the somatosensory system contributes more to shaping movements than to perception. Yet damage to the somatosensory system can result in spontaneous pain and other abnormal somatic perceptions. An exploration of the mechanisms and pathways involved in touch perception is slanted toward understanding the contribution of the dorsal column–medial lemniscus pathway to the generation of paresthesia and dysesthesia. Peripheral somatosensory afferents that contribute to the perception of sharp or aching pain, temperature, and itch are described. The properties of transient receptor potential (TRP) channels on nociceptors and thermoreceptors are described. Physiological and pharmacological mechanisms that lead to neurogenic inflammation are considered. How peripheral and central changes triggered by acute injury or disease can lead to long-lasting changes that support chronic pain is described. Persistent pain that occurs independently of any stimulus is termed neuropathic. Mechanisms of referred pain from deep structures including viscera are introduced.

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Частини книг з теми "Immunoregulatory properties and inflammation"

Blancou, Philippe, Virginie Tardif, Thomas Simon, Séverine Rémy, Leandro Carreño, Alexis Kalergis, and Ignacio Anegon. "Immunoregulatory Properties of Heme Oxygenase-1." In Methods in Molecular Biology, 247–68. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-869-0_18.

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Shirota, H., K. Chiba, M. Goto, R. Hashida, and H. Ono. "Antiinflammatory Properties of E5090, a Novel Orally Active Inhibitor of IL-1 Generation." In Drugs in Inflammation, 219–23. Basel: Birkhäuser Basel, 1991. http://dx.doi.org/10.1007/978-3-0348-7405-2_29.

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Zavala, Flora, Sarantis Korniotis, and Ruddy Montandon. "Characterization and Immunoregulatory Properties of Innate Pro-B-Cell Progenitors." In Methods in Molecular Biology, 79–88. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3139-2_5.

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Johnson, Howard M., and Barbara A. Torres. "Immunoregulatory Properties of Neuroendocrine Peptide Hormones (Part 1 of 2)." In Neuroimmunoendocrinology, 37–52. Basel: KARGER, 1988. http://dx.doi.org/10.1159/000318726.

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Johnson, Howard M., and Barbara A. Torres. "Immunoregulatory Properties of Neuroendocrine Peptide Hormones (Part 2 of 2)." In Neuroimmunoendocrinology, 53–67. Basel: KARGER, 1988. http://dx.doi.org/10.1159/000318727.

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Segovia, Mercedes, Maria Cristina Cuturi, and Marcelo Hill. "Preparation of Mouse Bone Marrow-Derived Dendritic Cells with Immunoregulatory Properties." In Methods in Molecular Biology, 161–68. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-869-0_11.

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Demircan, Pinar Çetinalp, Ayla Eker Sariboyaci, and Erdal Karaoz. "Immunoregulatory Properties of Mesenchymal Stem Cells: In Vitro and In Vivo." In Stem Cells: Current Challenges and New Directions, 29–58. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8066-2_3.

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Koo, Catherine H., Laurent Baud, Jeffrey W. Sherman, Jeanne P. Harvey, Daniel W. Goldman, and Edward J. Goetzl. "Molecular Properties of Leukocyte Receptors for Leukotrienes." In Cellular and Molecular Aspects of Inflammation, 305–19. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5487-1_15.

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Stimpson, S. A., J. H. Schwab, M. J. Janusz, S. K. Anderle, R. R. Brown, and W. J. Cromartie. "Acute And Chronic Inflammation Induced By Peptidoglycan Structures And Polysaccharide Complexes." In Biological Properties of Peptidoglycan, edited by Peter H. Seidl and Karl H. Schleifer, 273–90. Berlin, Boston: De Gruyter, 1986. http://dx.doi.org/10.1515/9783110874297-035.

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Page, C. P., C. B. Archer, and J. Morley. "Properties of PAF-acether Appropriate to a Mediator of Inflammation." In Inflammatory Mediators, 57–64. London: Palgrave Macmillan UK, 1985. http://dx.doi.org/10.1007/978-1-349-07834-9_6.

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Тези доповідей конференцій з теми "Immunoregulatory properties and inflammation"

Deshane, Jessy, Tong H. Jin, Zhihuan Sun, Marion Spell, Kim Estell, Casey T. Weaver, Victor J. Thannickal, Lisa M. Schwiebert, and David D. Chaplin. "Immunoregulatory Foxp3+ Myeloid Lineage Cells In Allergic Airway Inflammation." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4286.

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Liu, Qing, David Curran, Clemente J. Britto, Bhargavi Patham, and Lauren E. Cohn. "PLUNC Is An Immunoregulatory Protein That Controls Eosinophilia In Allergic Airway Inflammation." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5595.

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"From poverty to depression to inflammation: a literature review." In International Conference on Public Health and Humanitarian Action. International Federation of Medical Students' Associations - Jordan, 2022. http://dx.doi.org/10.56950/ovii9740.

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Background: Depression is the most commonly presented psychiatric disorder1 . People with low socioeconomic status are more likely to experience depression compared to those with higher socioeconomic status2 . Recent studies have revealed that people experiencing depression symptoms have a greater vulnerability to infections3 . Also, it has been shown in recent studies that there is a correlation between irregular cytokine levels and an uncontrolled inflammatory response4 . Objective: The present review addresses the relationship between the immune system response and depression. In addition to the relationship between depression and low socioeconomic status. Method: We searched PubMed for relevant studies describing the relationship between inflammatory response, depression, and low-income. Our literature survey was limited to peer-reviewed articles, written in English and published from 1990 until August 2022. Results: Different studies confirmed that psychological stress causes an alteration in the level of cytokines in multiple mechanisms4,5. Hypothalamus-pituitary-adrenal axis (HPA) is a significant immunoregulatory pathway that is activated in a variety of stress circumstances, including psychological stress6,7. Chronic psychological stress results in glucocorticoid resistance due to overactivity of the HPA axis. As a result, the inflammatory response is not appropriately managed4 . (Table1) explains the changes in the level of cytokines8 . Contrastingly, antidepressant treatment may restore normal cytokine production and decrease the risk of abnormal inflammatory response9 . Conclusion: More attention should be given to the low-middle income population and their limited access to psychiatric services as they have a higher chance of experiencing mental health disorders. Depression, which is one of the most common mental health illnesses, increases the incidence of infectious diseases. Moreover, it affects the inflammatory response. Due to the shortage of clinical trials on this subject, we recommend doing more studies to identify these clinical aspects.

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Chikamatsu, Kazuaki, Goro Takahashi, Koichi Sakakura, Soldano Ferrone, and Keisuke Masuyama. "Abstract 5314: Immunoregulatory properties of CD44+ cancer stem-like cells in squamous cell carcinoma of the head and neck." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-5314.

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Jang, J., M. Chen, S. Farahnak, and J. G. Martin. "Modulation of CD4+T Cell Properties by Airway Smooth Muscle Cell Mediated Inflammation." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2853.

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Szymanski, Lukasz, Aleksander Zakrzewski, Martyna Ciepielak, Aleksandra Cios, Weronika Urbanska, Jerzy Kruszewski, Wanda Stankiewicz, and Andrzej Chciałowski. "The effect of specific Hymenoptera VIT using the ultra-rush method on immunoregulatory properties of T and B Lymphocytes, histamine, tryptase and serum cytokine concentrations." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.237.

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Nascimento, E., W. Nunes, S. Costa-Silva, M. Roza, O. Nobrega, W. Machado-Silva, V. Amado, and C. Melo-Silva. "Effects of Combined Exercise Training in Respiratory System Mechanical Properties and Inflammation in Rats with Hepatopulmonary Syndrome." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2067.

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Myles, Valtresa, Jun Liao, and James N. Warnock. "Cyclic Pressure and Angiotensin II Influence the Biomechanical Properties of Aortic Valves." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80768.

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Hypertension is a known risk factor for aortic valve stenosis. The elevated blood pressure increases the transvalvular load and can elicit inflammation and extra-cellular matrix (ECM) remodeling. Elevated cyclic pressure and the vasoactive agent angiotensin II (Ang II) have both been shown to promote collagen synthesis, one of the early hallmarks of aortic sclerosis [1,2]. In the current study, it was hypothesized that the increased collagen production induced by either elevated pressure conditions or the presence of Ang II would affect the mechanical properties of the tissue by increasing stiffness.

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Maidhof, Robert, Neena Rajan, and Nadeen O. Chahine. "Effect of Inflammation on the Osmotic Response of Nucleus Pulposus Cells." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80358.

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Intervertebral disc (IVD) degeneration is accompanied by elevated levels of pro-inflammatory cytokines, particularly IL-1β and TNF-α [1]. Disc cells from the nucleus pulposus (NPs) respond to cytokine stimulation with increased catabolic breakdown of the tissue, resulting in a positive feedback of disc integrity loss and further inflammation [2]. Previous studies by our group have examined the response of NP cells to Toll-Like Receptor-4 (TLR-4) activation through stimulation with lipopolysaccharide (LPS). TLR-4 is a pattern recognition receptor that is activated in innate immunity and by polysaccharide fragments from degenerated proteoglycans. TLR-4 activation by LPS results in stimulation of multiple cytokines by NP cells [3]. Moreover, we have shown that in vivo LPS injection results in catabolic changes in the IVD, including matrix breakdown, decrease in biomechanical properties and loss of disc height [4]. However, the specific cellular mechanisms for these catabolic changes remain to be elucidated.

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Hsiao, HsiMin, Thomas H. Thatcher, Robert A. Fulton, Elizabeth P. Levy, Charles Serhan, Richard P. Phipps, and Patricia J. Sime. "Resolvin D1 Attenuates Cigarette Smoke-Induced Lung Inflammation By Upregulating Alternatively Activated Macrophages (M2) With Anti-Inflammatory And Pro-Resolving Properties." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1426.

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Звіти організацій з теми "Immunoregulatory properties and inflammation"

Schwartz, Bertha, Vaclav Vetvicka, Ofer Danai, and Yitzhak Hadar. Increasing the value of mushrooms as functional foods: induction of alpha and beta glucan content via novel cultivation methods. United States Department of Agriculture, January 2015. http://dx.doi.org/10.32747/2015.7600033.bard.

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During the granting period, we performed the following projects: Firstly, we differentially measured glucan content in several pleurotus mushroom strains. Mushroom polysaccharides are edible polymers that have numerous reported biological functions; the most common effects are attributed to β-glucans. In recent years, it became apparent that the less abundant α-glucans also possess potent effects in various health conditions. In our first study, we explored several Pleurotus species for their total, β and α-glucan content. Pleurotuseryngii was found to have the highest total glucan concentrations and the highest α-glucans proportion. We also found that the stalks (stipe) of the fruit body contained higher glucan content then the caps (pileus). Since mushrooms respond markedly to changes in environmental and growth conditions, we developed cultivation methods aiming to increase the levels of α and β-glucans. Using olive mill solid waste (OMSW) from three-phase olive mills in the cultivation substrate. We were able to enrich the levels mainly of α-glucans. Maximal total glucan concentrations were enhanced up to twice when the growth substrate contained 80% of OMSW compared to no OMSW. Taking together this study demonstrate that Pleurotuseryngii can serve as a potential rich source of glucans for nutritional and medicinal applications and that glucan content in mushroom fruiting bodies can be further enriched by applying OMSW into the cultivation substrate. We then compared the immune-modulating activity of glucans extracted from P. ostreatus and P. eryngii on phagocytosis of peripheral blood neutrophils, and superoxide release from HL-60 cells. The results suggest that the anti-inflammatory properties of these glucans are partially mediated through modulation of neutrophileffector functions (P. eryngiiwas more effective). Additionally, both glucans dose-dependently competed for the anti-Dectin-1 and anti-CR3 antibody binding. We then tested the putative anti-inflammatory effects of the extracted glucans in inflammatory bowel disease (IBD) using the dextran sulfate sodium (DSS)–induced model in mice. The clinical symptoms of IBD were efficiently relieved by the treatment with two different doses of the glucan from both fungi. Glucan fractions, from either P. ostreatus or P. eryngii, markedly prevented TNF-α mediated inflammation in the DSS–induced inflamed intestine. These results suggest that there are variations in glucan preparations from different fungi in their anti-inflammatory ability. In our next study, we tested the effect of glucans on lipopolysaccharide (LPS)-induced production of TNF-α. We demonstrated that glucan extracts are more effective than mill mushroom preparations. Additionally, the effectiveness of stalk-derived glucans were slightly more pronounced than of caps. Cap and stalk glucans from mill or isolated glucan competed dose-dependently with anti-Dectin-and anti-CR-3 antibodies, indicating that they contain β-glucans recognized by these receptors. Using the dextran sulfate sodium (DSS)-inflammatory bowel disease mice model, intestinal inflammatory response to the mill preparations was measured and compared to extracted glucan fractions from caps and stalks. We found that mill and glucan extracts were very effective in downregulatingIFN-γ and MIP-2 levels and that stalk-derived preparations were more effective than from caps. The tested glucans were equally effective in regulating the number of CD14/CD16 monocytes and upregulating the levels of fecal-released IgA to almost normal levels. In conclusion, the most effective glucans in ameliorating some IBD-inflammatory associated symptoms induced by DSS treatment in mice were glucan extracts prepared from the stalk of P. eryngii. These spatial distinctions may be helpful in selecting more effective specific anti-inflammatory mushrooms-derived glucans. We additionally tested the effect of glucans on lipopolysaccharide-induced production of TNF-α, which demonstrated stalk-derived glucans were more effective than of caps-derived glucans. Isolated glucans competed with anti-Dectin-1 and anti-CR3 antibodies, indicating that they contain β-glucans recognized by these receptors. In conclusion, the most effective glucans in ameliorating IBD-associated symptoms induced by DSS treatment in mice were glucan extracts prepared from the stalk of P. eryngii grown at higher concentrations of OMSW. We conclude that these stress-induced growing conditions may be helpful in selecting more effective glucans derived from edible mushrooms. Based on the findings that we could enhance glucan content in Pleurotuseryngii following cultivation of the mushrooms on a substrate containing different concentrations of olive mill solid waste (OMSW) and that these changes are directly related to the content of OMSW in the growing substrate we tested the extracted glucans in several models. Using dextran sulfate sodium (DSS)–inflammatory bowel disease (IBD) mice model, we measured the colonic inflammatory response to the different glucan preparations. We found that the histology damaging score (HDS) resulting from DSS treatment reach a value of 11.8 ± 2.3 were efficiently downregulated by treatment with the fungal extracted glucans, glucans extracted from stalks cultivated at 20% OMSWdownregulated to a HDS value of 6.4 ± 0.5 and at 80% OMSW showed the strongest effects (5.5 ± 0.6). Similar downregulatory effects were obtained for expression of various intestinal cytokines. All tested glucans were equally effective in regulating the number of CD14/CD16 monocytes from 18.2 ± 2.7 % for DSS to 6.4 ± 2.0 for DSS +glucans extracted from stalks cultivated at 50% OMSW. We finally tested glucans extracted from Pleurotuseryngii grown on a substrate containing increasing concentrations of olive mill solid waste (OMSW) contain greater glucan concentrations as a function of OMSW content. Treatment of rat Intestinal epithelial cells (IEC-6) transiently transfected with Nf-κB fused to luciferase demonstrated that glucans extracted from P. eryngii stalks grown on 80% OMSWdownregulatedTNF-α activation. Glucans from mushrooms grown on 80% OMSW exerted the most significant reducing activity of nitric oxide production in lipopolysaccharide (LPS) treated J774A.1 murine macrophages. The isolated glucans were tested in vivo using the Dextran Sodium Sulfate (DSS) induced colitis in C57Bl/6 mice and found to reduce the histology damaging score resulting from DSS treatment. Expression of various intestinal cytokines were efficiently downregulated by treatment with the fungal extracted glucans. We conclude that the stress-induced growing conditions exerted by OMSW induces production of more effective anti-inflammatory glucans in P. eryngii stalks.

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