Дисертації з теми "Immunological Analyses"
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Tran, Emily. "Immunological and molecular analyses of the Borrelia burgdorferi OSPF protein family /." Also available to VCU users at:, 2006. http://hdl.handle.net/10156/1917.
Повний текст джерелаParry, David Alun. "Biochemical and functional analyses of p16INK4a, an inhibitor of cyclin D-dependent kinases." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243499.
Повний текст джерелаVemulapalli, Tracy H. "Genetic and Immunological Analyses of a Brucella abortus Protein Exhibiting Lectin-like Properties." Thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/31194.
Повний текст джерелаMaster of Science
Matthews, Kerryn. "Immunological analysis of pericardial tuberculosis." Doctoral thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/11101.
Повний текст джерелаPericardial tuberculosis (TB) offers a relevant human model to study TB at the site of disease and to determine the effect of HIV-1 infection. 96 Patients with pericardial TB were recruited into this study, 68 of whom were HIV-1 infected. Where clinically indicated, pericardiocentesis was performed to drain pericardial fluid and blood was drawn. The data derived from the study provide novel insight into the immune response in the pericardium to TB infection. Furthermore, HIV-1 infection caused a dysregulation of the immune response.
Montano, C. X. "Immunological analysis of SV40 early region products." Thesis, Imperial College London, 1985. http://hdl.handle.net/10044/1/37789.
Повний текст джерелаGonzalez-Rabade, N. "Immunological analysis of chloroplast-derived HIV-1 antigens." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599489.
Повний текст джерелаCELNIKER, ABBIE CHERYL. "IMMUNOLOGICAL STUDIES OF HUMAN CATHEPSIN D (LYSOSOMAL ENZYME, ACID PROTEINASE)." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183856.
Повний текст джерелаElliott, Michael. "Immunological, virological and molecular biological analysis of nasopharyngeal carcinoma /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18427.pdf.
Повний текст джерелаRoss, Owen A. "Analysis of genetic and immunological factors associated with ageing." Thesis, University of Ulster, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274056.
Повний текст джерелаOdendaal, Ruenda. "A biochemical and immunological study of horseradish peroxidase." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/1587.
Повний текст джерелаENGLISH ABSTRACT: This study describes: a) the isolation and purification of horseradish peroxidase isoenzymes from horseradish roots, b) the characterization of various forms and components of the enzyme by cation-exchange and reversed-phase high performance liquid chromatography, c) the preparation of antibodies against horseradish peroxidase isoenzymes, d) immunological studies for the development of an isoenzyme quantification method and e) the formation of an enzyme-melamine conjugate for use in a melamine quantification immunoassay.
AFRIKAANSE OPSOMMING: Hierdie studie beskryf: a) die isolering en suiwering van peperwortel-peroksidase-isoënsieme vanuit die peperwortel, b) die karakterisering van verskillende vorme en komponente van dié ensiem deur katioonuitruilings en omgekeerde-fase HPLC c) die voorbereiding van teenliggaampies vir peperwortel-peroksidase-isoënsieme, d) immunologiese studies vir die ontwikkeling van 'n isoënsiem-kwantifiseringsmetode; en e) die vorming van 'n ensiem-melamien-konjugaat vir gebruik in 'n melamienkwantifiseringsmetode.
Cavar, Marko. "Mutational Analysis of CD127 and Its Role in Immunological Diseases." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34404.
Повний текст джерелаHassan, Syed Saeed-Ul. "Rapid immunological methods for analysis of dexamethasone in equine urine." Thesis, University of Sunderland, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245822.
Повний текст джерелаMcLean, William Henry Irwin. "Electrophoretic and immunological analysis of proteins in the muscular dystrophies." Thesis, Queen's University Belfast, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335992.
Повний текст джерелаCox, Peter John. "Molecular and immunological analysis of EHV-1 and -4 infections." Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285022.
Повний текст джерелаAdeleye, Tolulope Abiodun. "A molecular analysis of the immunological response to mycobacterial antigens." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304066.
Повний текст джерелаMann, Aisling M. "Immunological and biochemical techniques in the analysis of tear proteins." Thesis, Aston University, 1998. http://publications.aston.ac.uk/9598/.
Повний текст джерелаHan, Qing Ph D. Massachusetts Institute of Technology. "Generating immunological signatures of diseases by multiplex analysis of single cells." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/76485.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references (p. 135-142).
The large diversity of cells that comprise the human immune system requires methods that can resolve the contributions of individual cells to an immunological response. The release of cytokines is one of several important functions carried out by immune cells. Analytical methods that yield multiple measures of the breadth and quality of cytokine secretion from heterogeneous populations are highly desired in basic and clinical immunology. Microengraving is a process that uses a dense, elastomeric array of nanowells to generate microarrays of proteins secreted from large numbers of individual live cells. In this thesis, we improved the sensitivity and multiplicity of microengraving and adapted it to detect cytokine secretions from primary immune cells. We demonstrated that microengraving could provide quantitative measurements of both the frequencies and the distribution in rates of secretion for up to four cytokines simultaneously. The experimental limits of detection ranged from 0.5 to 4 molecules/s for most cytokines in our experiments. These multidimensional measures resolve functional responses by cells exposed to stimuli with greater sensitivity than single-parameter assays. Primary T cells with specific profiles of secretion can also be recovered after microengraving for subsequent expansion in vitro. The release of multiple cytokines by T cells has been associated with beneficial immune responses. To date, however, time-integrated end-point measurements have not resolved the temporal dynamics of these functions. Here, we used serial microengraving to measure Thlskewed cytokine responses (IFN[gamma], IL-2, TNF[alpha]) from individual cells after activation ex vivo. The results show that multifunctional cytokine responses are initiated asynchronously but the ensuing dynamic trajectories of these responses evolve programmatically in a sequential manner. Furthermore, these dynamic trajectories are strongly associated with the various states of cell differentiation, suggesting that transient programmatic activities of many individual T cells contribute to sustained, population-level responses. The trajectories of responses by single cells may also provide unique, time-dependent signatures for immune monitoring that are less compromised by the timing and duration of integrated measures. Together, these results demonstrate the utility of quantitative, multidimensional profiles of single cells for analyzing the diversity and dynamics of immune responses in vitro, thus generating immune signatures for diseases.
by Qing Han.
Ph.D.
Örtqvist, Eva. "The importance of immunological, genetic and clinical factors for beta cell function in childhood diabetes /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4632-9/.
Повний текст джерелаReid, Helen Isobel. "Molecular and immunological analysis of recombinant Bacteroides forsythus heat shock protein 60." Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321982.
Повний текст джерелаZal, Behnam. "Biosynthesis and immunological analysis of the dominant phosphoprotein ppUL83 of human cytomegalovirus." Thesis, St George's, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313517.
Повний текст джерелаGalbraith, Daniel Norman. "Molecular and immunological analysis and detection of the forest pathogen Heterbasidion annosum." Thesis, University of Abertay Dundee, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359300.
Повний текст джерелаRoßmann, Laura [Verfasser]. "In-depth immunological analysis of prototypic adjuvants for vaccine formulations / Laura Roßmann." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2020. http://d-nb.info/1223379299/34.
Повний текст джерелаWilson, Lisa. "Immunological analysis of drugs of abuse with reference to anhydroecgonine methyl ester." Thesis, Sheffield Hallam University, 2007. http://shura.shu.ac.uk/20704/.
Повний текст джерелаSaville, Stephen Paul. "Analysis of yeast proteins with immunological or sequence similarities to mammalian PKC isozymes." Thesis, University of Leicester, 1998. http://hdl.handle.net/2381/30311.
Повний текст джерелаThilaganathan, Baskaran. "Investigation of fetal immunological development by flow cytometric analysis of circulating lymphocyte subpopulations." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244163.
Повний текст джерелаManso-Silvan, Lucia. "Identification and analysis of immunologically relevant antigens from Mycoplasma hyopneumoniae." Thesis, Royal Veterinary College (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404983.
Повний текст джерелаVacca, Irene <1985>. "Analysis of the immunological and functional features of the Neisserial Heparin Binding Antigen (NHBA)." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6490/.
Повний текст джерелаGlancy, Heather. "Detection and analysis of the wood decay fungus Lentinus lepidus Fr. using immunological probes." Thesis, University of Abertay Dundee, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278052.
Повний текст джерелаHageman, John Robert. "A morphometric and immunological analysis of kidney flask cells from the frog Xenopus laevis /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487682558447011.
Повний текст джерелаGure, Ali Osmay. "Analysis of TNF mediated cytotoxicity /." Access full-text from WCMC, 1995. http://proquest.umi.com/pqdweb?did=733006521&sid=10&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Повний текст джерелаPadilla, Lacy Ann. "GROUNDSTONE ANALYSIS AT THE ROCK CAMP SITE." CSUSB ScholarWorks, 2017. https://scholarworks.lib.csusb.edu/etd/603.
Повний текст джерелаTeng, Yen-Tung Andy. "Analysis of the mechanism(s) of immunological tolerance to a physiological soluble antigen in transgenic mice." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/Nq27740.pdf.
Повний текст джерелаEliasson, Hanna. "Development of immunological methods and Real-Time PCR for detection of Macadamia nut (Macadamia spp.)." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6150.
Повний текст джерелаA new European labeling directive (2003/89/EC) states that certain foods and products derived thereof must always be declared. Among the tree nuts specified is Macadamia nut (Macadamia spp.). During the last few years, cases of IgE-allergic reactions, even severe anaphylaxes, have been reported. Reliable methods for the detection of this nut are needed.
Protein from Macadamia nuts was isolated. Polyacrylamide gel electrophoresis in SDS revealed two main protein bands of about 20 and 50kDa. These protein bands were cut and extracted from the gel and rabbits were immunized with each protein.
Immunoblotting showed dominant reactivity with the respective antigens. The antisera were further tested for specificity in immunodiffusion and in rocket immunoelectrophoresis.
In addition, a specific DNA-method was developed, based on Real-Time PCR using Macadamia vicilin as target sequence. Two different primer pairs were tested. Specificity was tested against potentially related nuts. Optimisation of primer and probe concentrations was performed. The limit of detection was 2-4 pg DNA, corresponding to a macadamia nut concentration of 50 to 100 μg per g. In a background of soybean DNA, down to 0,01 % macadamia DNA could be detected.
Guy, Rebecca Ann. "Giardia lamblia : an analysis of trophozoite antigens using monoclonal antibodies." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55696.
Повний текст джерелаHarder, Jutta [Verfasser], da Costa Clarissa [Akademischer Betreuer] Prazeres, Bettina [Gutachter] Kuschel, and da Costa Clarissa [Gutachter] Prazeres. "Vitamin D receptor and its immunological role within the human placenta - Analysis of vitamin D metabolism and immunologically important genes at the feto-maternal interface / Jutta Harder ; Gutachter: Bettina Kuschel, Clarissa Prazeres da Costa ; Betreuer: Clarissa Prazeres da Costa." München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1203799446/34.
Повний текст джерелаMatt, Muriel. "Concept et développement d'un immunodosage par polarisation de fluorescence de biomolécules à fonction carboxyle : application à la prostaglandine E1 et au thromboxane B2." Vandoeuvre-les-Nancy, INPL, 1993. http://docnum.univ-lorraine.fr/public/INPL_T_1993_MATT_M.pdf.
Повний текст джерелаKolibab, Kristopher Adam. "Immunological and Molecular Analysis in Elderly and Young Adults in Response to Pneumococcal Polysaccharides 4 and 14." University of Toledo Health Science Campus / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=mco1121869959.
Повний текст джерелаChan, Agnes How-Ching. "Purification, biochemical analysis and sequencing of a novel murine T suppressor factor." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28638.
Повний текст джерелаScience, Faculty of
Microbiology and Immunology, Department of
Graduate
Gadd, Stephen J. "Analysis of acute mycloid leukaemia cell surface antigens with monoclonal antibodies." Title page, contents and abstract only, 1985. http://web4.library.adelaide.edu.au/theses/09PH/09phg123.pdf.
Повний текст джерелаSchmedt, Erich M. "An immunological analysis of a cell surface antigen in oocytes and embryos of the mud snail, Ilyanassa obsoleta /." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63257.
Повний текст джерелаFukazawa, Yoshinori. "Virological and immunological analysis of systemic lymphoid tissues in the early phase of simian-human immunodeficiency virus infection." Kyoto University, 2009. http://hdl.handle.net/2433/123950.
Повний текст джерела0048
新制・課程博士
博士(人間・環境学)
甲第14735号
人博第471号
新制||人||115(附属図書館)
20||人博||471(吉田南総合図書館)
UT51-2009-D447
京都大学大学院人間・環境学研究科相関環境学専攻
(主査)准教授 三浦 智行, 教授 五十嵐 樹彦, 教授 小松 賢志
学位規則第4条第1項該当
Lähdesmäki, Aleksi. "Functional analysis of ATM with relevance for primary immunodeficiency and tumor formation /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-900-5/.
Повний текст джерелаJin, Jing, and 金晶. "Proteomic profiling of mycelial extract derived from coriolus versicolor and analysis of their anti-tumor effects in human leukemiccells HL-60." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B41897110.
Повний текст джерелаJin, Jing. "Proteomic profiling of mycelial extract derived from coriolus versicolor and analysis of their anti-tumor effects in human leukemic cells HL-60." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B41897110.
Повний текст джерелаChoi, Chang Won. "Soybean mosaic virus-soybean interactions : molecular, biochemical, physiological, and immunological analysis of resistance responses of soybean to soybean mosaic virus /." Diss., This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-07282008-134858/.
Повний текст джерелаBallenberger, Nikolaus Verfasser], and Erika von [Akademischer Betreuer] [Mutius. "Novel statistical approaches for censored immunological data : analysis of cytokine and gene expression data / Nikolaus Ballenberger. Betreuer: Erika von Mutius." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1031380388/34.
Повний текст джерелаBrunet, Jean-François. "Recherche et caractérisation des activités anticorps des liquides kystiques des tumeurs cérébrales." Université Joseph Fourier (Grenoble ; 1971-2015), 1994. http://www.theses.fr/1994GRE10222.
Повний текст джерелаMaphumulo, Philile Nompumelelo. "Characterisation of a plasmodium falciparum type II Hsp40 chaperone exported to the cytosol of infected erythrocytes." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/d1015681.
Повний текст джерелаScherr, Adolfo José de Oliveira 1979. "Terapia adjuvante pós tratamento cirúrgico no carcinoma renal : revisão sistemática da literatura com meta-análise." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313866.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-22T03:20:05Z (GMT). No. of bitstreams: 1 Scherr_AdolfoJosedeOliveira_M.pdf: 1501111 bytes, checksum: acf22564245404a459e366435fc5790b (MD5) Previous issue date: 2013
Resumo: Pacientes com câncer renal localmente avançado são de alto risco para recidiva após ressecção cirúrgica com intuito curativo. Muitos estudos têm sido realizados na tentativa de se descobrir alguma intervenção adjuvante capaz de reduzir este risco. No entanto, até o momento não foi observado nenhum benefício clínico nas intervenções avaliadas nos estudos. O objetivo desta revisão sistemática foi avaliar o exato papel da terapia adjuvante nos pacientes com câncer renal localmente avançado após cirurgia. Foram selecionados estudos clínicos randomizados que comparavam terapia adjuvante (quimioterapia, vacinas, imunoterapia, bioquimioterapia, hormonioterapia) versus nenhum tratamento ativo após cirurgia em pacientes com câncer renal. Os desfechos clínicos avaliados foram sobrevida global (SG), sobrevida livre de doença (SLD) e toxicidades severas. A análise dos dados extraídos foi realizada no programa estatístico Review Manager 5.0 (RevMan 5; Cochrane Collaboration Software). As diferentes estratégias de tratamento adjuvante foram avaliadas em conjunto e separadamente. Dez estudos (2609 pacientes) foram incluídos. Terapia adjuvante não mostrou benefício em termos de SG (HR 1.07; IC95% 0.89 a 1.28; P = 0.48 I2= 0%) ou SLD (HR 0,96; IC95% 0.83 a 1.10; P =0.52 I2= 36%) quando comparado a nenhum tratamento adjuvante. Nenhuma análise de subgrupo (imunoterapia,vacinas, bioquimioterapia) atingiu resultado relevante. A avaliação de toxicidades mostrou uma frequencia significativamente maior de eventos adversos graves no grupo tratado (OR 73.86; IC 95% 28,32 a 192,62; P < 0,00001 I2 = 37%). O resultado final da análise não forneceu nenhum suporte para a hipótese de que os agentes estudados forneçam qualquer benefício clínico para pacientes com câncer renal no contexto adjuvante, além de aumentarem o risco de efeitos adversos graves. Estudos clínicos randomizados que avaliam o uso de terapias-alvo no cenário adjuvante estão em andamento e podem abrir uma nova fronteira terapêutica para estes pacientes. Até que os resultados destes estudos sejam conhecidos e se mostrem efetivos, nenhuma terapia adjuvante pode ser recomendada para pacientes com câncer de células renais após ressecção cirúrgica curativa
Abstract: Many adjuvant trials have been undertaken in an attempt to reduce the risk of recurrence among patients who undergo surgical resection for locally advanced renal cancer. However, no clear benefit has been identified to date. This systematic review was conducted to examine the exact role of adjuvant therapy in renal cancer setting. Randomized controlled trials were searched comparing adjuvant therapy (chemotherapy, vaccine, immunotherapy, biochemotherapy, hormone therapy) versus no active treatment after surgery among renal cell cancer patients. Clinical outcomes were overall survival (OS), disease-free survival (DFS), and severe toxicities. The extracted data was performed using the statistical software Review Manager 5.0 (RevMan 5; Cochrane Collaboration Software).Different strategies of adjuvant treatment were evaluated together and separately. Ten studies (2,609 patients) were included. Adjuvant therapy provided no benefits in terms of OS (HR 1.07; 95%CI 0.89 to 1.28; P = 0.48 I2 = 0%) or DFS (HR 0,96; CI 95% 0.83 to 1.10; P =0.52 I2 = 36%) when compared to no treatment. No subgroup analysis (immunotherapy, vaccines, biochemotherapy) had relevant results. Toxicity evaluation depicted a significantly higher frequency of serious adverse events in the adjuvant group(OR 73.86; CI 95% 28,32to 192,62; P < 0,00001 I2 = 37%).The result of the analysis provided no support for the hypothesis that the agents studied provide any clinical benefit for renal cancer patients in the adjuvant setting, in addition to increasing the risk of serious adverse events. Randomized trials are underway to test targeted therapies in adjuvant setting, which might open a new therapeutic frontier for these patients. Until these trials yield results, no adjuvant therapy can be recommended for patients who undergo surgical curative resection for renal cell cancer
Mestrado
Clinica Medica
Mestre em Clinica Medica
Mei, Henrik Eckhard. "Analysen zur differentiellen Plasmazellhomöostase beim Menschen." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16048.
Повний текст джерелаHumoral memory, i.e. persistence of specific antibody titers, is provided by plasma cells in the bone marrow, which are generated from activated B cells during immune responses. At this, immediate plasma cell precursors, the plasmablasts, migrate via the blood to the bone marrow. Using cytometric detection of antigen-specific plasmablasts, synchronous circulation of waves of recently generated, migratory plasmablasts and non migratory plasma cells with a mature phenotype was demonstrated one week after tetanus vaccination. Circulating plasmablast and plasma cell numbers were always in homeostasis, so that the stoichiometric mobilization of old bone marrow plasma cells by recently generated plasmablasts was hypothesized. This plasma cell replacement mechanism is herein described for the first time as an adaption mechanism of the humoral memory that allows incorporation of new antibody specificities while maintaining pre-existing ones. In immunological steady state, very low numbers of plasmablasts are detectable in any donor. These express IgA and receptors for mucosal homing, alpha4beta7 integrin and CCR10, and therefore most likely migrate into mucosal plasma cell depots and do not interfere with plasma cells of the bone marrow, preserving the stability of humoral memory during steady state. Hence, adaption of humoral memory is only possible during systemic immune reactions. Circulating mucosal plasmablasts produced during steady state remain detectable in patients with rheumatoid arthritis during B cell depletion therapy as well as in asplenic patients. Hence, this type of plasmablasts is self-sufficiently generated from mucosal B cells that are refractory to B cell depletion therapy. This work demonstrates a hitherto disregarded complexity of peripheral plasmablast and plasma cell subsets in healthy humans, with implications for the regulation of induction and maintenance of humoral memory.