Дисертації з теми "Immunoglobulin A"
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Das, Mrinmoy. "The regulatory effects of circulating normal immunoglobulins on autophagy and Th17 response." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066153/document.
Повний текст джерелаCirculating immunoglobulins play a critical role in the immune homeostasis by modulating the functions of immune cells. In my thesis, I investigated the regulatory effects of therapeutic immunoglobulin G (IVIG) and circulating monomeric immunoglobulin A (mIgA) on autophagy and human Th17 response respectively. IVIG is a therapeutic preparation of pooled normal IgG. It is used as an anti-inflammatory agent in the treatment of a wide variety of autoimmune and inflammatory diseases. However, the mechanisms are not yet fully elucidated and several mutually non-exclusive mechanisms have been proposed. Autophagy is an important biological process involving lysosomal degradation of damaged cellular components and misfolded proteins. There are several evidences that support the involvement of autophagy in autoimmune and auto- inflammatory disorders including the discovery of polymorphisms in autophagy-related genes. I show that induction of autophagy by IVIG represents a novel mechanism of action in achieving therapeutic effect in autoimmune and inflammatory diseases. Th17 cells represent an attractive target to treat several inflammatory and autoimmune diseases. Despite being second most abundant antibody in the circulation, the immunoregulatory function of IgA is relatively unexplored. I have shown that monomeric IgA (mIgA) inhibits differentiation and amplification of human Th17 cells and the production of their effector cytokine IL-17A
Carpenet, Guéry Hélène. "Radiomarquage au 99mTc des IgA et IgG : optimisation du marquage, étude in vitro, biodistribution chez l'animal sain et sur modèle tumoral." Thesis, Limoges, 2015. http://www.theses.fr/2015LIMO0074/document.
Повний текст джерелаSince their discovery in 1975, by Köhler and Milstein, monoclonal antibodies (mAbs) world has significantly evolved and they currently hold a prominent place in cancers care. Today, the mAbs, having a marketing authorization or in clinical trial, are all IgG class (IgG1). However, this Ab class showed limitations on its use, and the study of other isotypes, such as IgA, could be interesting. Unlike IgG, IgA, original isotype particularly because of their heterogeneity in molecular forms, remains understudied. In this work, we propose a radiolabeling of monomeric, polymeric and secretory IgA with 99mTc by an indirect method, involving 2-iminothiolane and tricarbonyl core. Biodistribution of radiolabeled monomeric and polymeric IgA was evaluated, after intravenous administration, in healthy animals and in mucosal tumor-bearing animals. These studies have allowed us to glimpse the IgA diagnostic potential, but also their interest in targeted therapy of tumors with mucosal localization. Moreover, thanks to their enzymatic strength and retranscytosis, a new administration route of mAbs could be developed. In this context, secretory IgA were administered orally in preliminary biodistribution studies
Hirano, Ayumi. "T dependent B cell help in cattle : immunoregulatory function of interleukin-4 and CD40-CD40L interactions /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9841150.
Повний текст джерелаAlmroth, Gabriel. "Immunoglobulins, immunoglobulin subclass-distributions and serologic markers in some renal and systemic disorders /." Linköping : Univ, 2000. http://www.bibl.liu.se/liupubl/disp/disp2000/med646s.pdf.
Повний текст джерелаRogers, Kenneth Alton. "Immunoglobulins and Immunoglobulin Fc Receptors in Nonhuman Primates Commonly Used in Biomedical Research." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/biology_diss/6.
Повний текст джерелаDing, Cheng. "Siglec-G is a negative regulator of NF-[kappa]B activation and has pivotal roles in B-1 cell development and resistance to sepsis /." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1226876722.
Повний текст джерелаLaurencikiene, Jurga. "Regulation of germline transcription in the immunoglobulin heavy chain locus /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-989-7/.
Повний текст джерелаCouston, Ruairidh Gair. "Characterising immunoglobulin-polysorbate interactions." Thesis, University of Strathclyde, 2013. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=18963.
Повний текст джерелаPouria, Shideh. "A study of immunoglobulin A biology in primary and hepatic immunoglobulin A nephropathy." Thesis, King's College London (University of London), 2005. https://kclpure.kcl.ac.uk/portal/en/theses/a-study-of-immunoglobulin-a-biology-in-primary-and-hepatic-immunoglobulin-a-nephropathy(e31804ca-526c-49d0-8767-9110d84f7a4b).html.
Повний текст джерелаMason, J. O. "Regulation of immunoglobulin gene expression." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384506.
Повний текст джерелаHunt, James. "Structural studies of immunoglobulin E." Thesis, King's College London (University of London), 2004. https://kclpure.kcl.ac.uk/portal/en/theses/structural-studies-of-immunoglobulin-e(251aec27-5e3a-4ce5-9fbe-9493d158129d).html.
Повний текст джерелаWang, Hui. "Immunoglobulin binding proteins in ticks." Thesis, University of Oxford, 1995. http://ora.ox.ac.uk/objects/uuid:7c09068b-82fb-4434-9e84-4663cbab7795.
Повний текст джерелаSukumaran, Muralidharan. "Optical sensors for immunoglobulin G." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620564.
Повний текст джерелаDoré, Katy Alison. "The evolution of immunoglobulin E." Thesis, King's College London (University of London), 2015. https://kclpure.kcl.ac.uk/portal/en/theses/the-evolution-of-immunoglobulin-e(4c611aa6-eed9-4abb-81f7-b9afe97e78bb).html.
Повний текст джерелаHabich, Hans. "Immunoglobulin therapy in ophthalmic diseases /." [S.l : s.n.], 1986. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Повний текст джерелаKoch, Urs Daniel. "Immunoglobulin therapy for herpes zoster /." [S.l.] : [s.n.], 1985. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Повний текст джерелаSearle, Stephen M. J. "Molecular modelling of immunoglobulin folds." Thesis, University of Bath, 1997. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246005.
Повний текст джерелаDidriksen, Nancy A. (Nancy Andrews). "Psychological Stress: Effect on Humoral Immune Functioning as Measured by Immunoglobulin Levels." Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc331278/.
Повний текст джерелаSellers, Lisa K. "Exercise-induced alterations in immunoglobulin (IgA, IgG, IgM) levels in cancer versus non-cancer patients." Muncie, Ind. : Ball State University, 2008. http://cardinalscholar.bsu.edu/384.
Повний текст джерелаPratt, Stephanie Ann. "Immunoglobulin A1 protease of Streptococcus pneumoniae." Thesis, University of Leicester, 1988. http://hdl.handle.net/2381/35410.
Повний текст джерелаYip, Bon-ham. "Immunoglobulin gene translocations in gastric lymphoma." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37345321.
Повний текст джерелаCorbett, S. J. "The human immunoglobulin diversity segment repertoire." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597991.
Повний текст джерелаYip, Bon-ham, and 葉邦瀚. "Immunoglobulin gene translocations in gastric lymphoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37345321.
Повний текст джерелаWatson, Nigel. "Monoclonal antibodies to human immunoglobulin allotypes." Thesis, University of Strathclyde, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304897.
Повний текст джерелаTomlinson, Ian Michael. "The human immunoglobulin Vâ†H repertoire." Thesis, Open University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295301.
Повний текст джерелаSale, Julian Edward. "Constitutive immunoglobulin gene hypermutation in vitro." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624417.
Повний текст джерелаCarrera, J. P., Zulma M. Cucunuba, Karen Neira, Ben Lambert, Yaneth Pitti, Jesus Liscano, Jorge L. Garzon, et al. "Endemic and epidemic human alphavirus infections in eastern Panama: An analysis of population-based cross-sectional surveys." American Society of Tropical Medicine and Hygiene, 2020. http://hdl.handle.net/10757/655503.
Повний текст джерелаNational Institute for Health Research
Revisión por pares
Roberts-Thomson, Peter John. "Low molecular weight IgM in health and disease /." Title page, index and abstract only, 1987. http://web4.library.adelaide.edu.au/theses/09MD/09mdr648.pdf.
Повний текст джерелаLohman, Isabelle Carlotta 1948. "THE PRODUCTION AND PURIFICATION OF RABBIT SERUM IMMUNOGLOBULIN-E, AND THE ROLE OF IMMUNOGLOBULIN-E IN SYSTEMIC ANAPHYLAXIS." Thesis, The University of Arizona, 1987. http://hdl.handle.net/10150/291183.
Повний текст джерелаSchiavo, Ebe. "Molecular mechanisms controlling immunoglobulin class switch recombination." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ084/document.
Повний текст джерелаDuring immune responses, B cell repertoire is diversified through somatic hypermutation (SHM) and class switch recombination (CSR). SHM and CSR require activation-induced cytidine deaminase (AID), which induces DNA damage. While AID deficiency abrogates SHM and CSR, C-terminal truncations impair CSR without affecting SHM and it has been proposed that AID C-terminal domain associates with CSR-specific factor(s). In order to identify these factors, we studied a human CSR-specific immunodeficiency, characterized by normal SHM and AID expression. B cells from these patients do not display DSBs at switch (S) regions, suggesting that they might lack an AID-binding factor(s) required to target AID to S regions during CSR. Through a multi- approach strategy, we identified and analyzed candidate factors, including Spt6, the cohesin complex and the Smc5/6 complex. We show that, in B cells poised to undergo CSR, AID is in a complex with Spt6, Spt5, the RNA polymerase II and the PAF complex while cohesins might regulate the 3D structure of the IgH locus and the pathway of DSBs repair at the Ig S regions. Our work thus contributes to a better understanding of the CSR reaction
Ordinario, Ellen. "Dynamics and mechanism of immunoglobulin gene diversification /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/9266.
Повний текст джерелаField, Helen. "On production of recombinant immunoglobulin variable domains." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330288.
Повний текст джерелаde, Bono B. "Immunoglobulin superfamily proteins in human and mouse." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598443.
Повний текст джерелаGeorge, Laura. "Regulation of extrafollicular immunoglobulin class switch recombination." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5109/.
Повний текст джерелаWright, Caroline Fiona. "Folding and aggregation of an immunoglobulin domain." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.616276.
Повний текст джерелаFraser, Louise. "Immunoglobulin light chains in Systemic Lupus Erythematosus." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/immunoglobulin-light-chains-in-systemic-lupus-erythematosus(759b46c1-24bc-427d-8b25-8987eec6f61f).html.
Повний текст джерелаFarley, Carol J. "Stress, appraised control, and salivary immunoglobulin A." Thesis, Anglia Ruskin University, 2010. http://arro.anglia.ac.uk/188989/.
Повний текст джерелаFarley, Carol J. "Stress, appraised control, and salivary immunoglobulin A." Thesis, Anglia Ruskin University, 2010. https://arro.anglia.ac.uk/id/eprint/188989/1/Thesis_Farley_2010.pdf.
Повний текст джерелаDixon, Emma Victoria. "Mechanisms of immunoglobulin deactivation by Streptococcus pyogenes." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:ec80e3f9-0c73-4d39-bc68-c39b927365d4.
Повний текст джерелаChintalacharuvu, Koteswara Rao. "Disulfide bond formation between dimeric immunoglobulin A and the polymeric immunoglobulin receptor in cultured epithelial cells and rat liver." Case Western Reserve University School of Graduate Studies / OhioLINK, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=case1055268413.
Повний текст джерелаBorthakur, Susmita. "Structural flexibility and immunoglobulin constant domains : role of the intrinsic flexibility of the C&3 domain of immunoglobulin E." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531955.
Повний текст джерелаBartholomeuz, Risien Chiron Andrew. "Polymeric IgA antibody in humans after vaccination and in disease /." Title page, contents and abstract only, 1989. http://web4.library.adelaide.edu.au/theses/09MD/09mdb287.pdf.
Повний текст джерелаJohansson, Karin. "Analysis of immunoglobulin gene expression focus on Oct2 /." Lund : Dept. of Cell and Molecular Biology, Lund University, 1995. http://catalog.hathitrust.org/api/volumes/oclc/39776663.html.
Повний текст джерелаHeidari, Ramesh. "Immunoglobulin VH gen analys in human B-cell." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7392.
Повний текст джерелаMalt lymphoma is a malignant disease that can arise in a variety of extra nodal sites. Previous studies indicate that tumour arise from more mature B-cells.
Our purpose was to examine the presence of clonality and somatic hypermutation of immunoglobulin (IgVн) of MALT lymphomas.
Paraffin-embedded tumour samples from13 MALT lymphoma were subjected to rearrangement analysis, by using PCR, heteroduplex gels and sequence analysis.
Successful amplification was seen in 10/13 cases and sequences of IgVн genes were obtained in 6/13, all of them were mutated. The percentage of mutation compared to germline sequences was 1,1% to 8,6% monoclonal rearrangemang. It was demonstrated that 5 of 7 clones were derived from the Vн3 family, 2 from Vн1 and 1 from the Vн 4 family.
Oancea, Adriana Ecaterina. "Immunoglobulin heavy chain gene expression in hybridoma cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0010/NQ28030.pdf.
Повний текст джерелаAndersson, Tove. "Transcription factors regulating the immunoglobulin heavy chain locus /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3559-9/.
Повний текст джерелаBetz, Alexander Guido. "Somatic hypermutation of immunoglobulin #KAPPA# light chain genes." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319561.
Повний текст джерелаDuncan, Alexander Robert. "The location of effector sites in immunoglobulin IgG." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238535.
Повний текст джерелаPreston, Alexandra McEwan. "Interactions of immunoglobulin superfamily leukocyte cell surface molecules." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318630.
Повний текст джерелаHamill, S. J. "Folding and evolution of the immunoglobulin-like superfold." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603613.
Повний текст джерела