Щоб переглянути інші типи публікацій з цієї теми, перейдіть за посиланням: Immunisation.

Дисертації з теми "Immunisation"

Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями

Оберіть тип джерела:

Ознайомтеся з топ-50 дисертацій для дослідження на тему "Immunisation".

Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.

Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.

Переглядайте дисертації для різних дисциплін та оформлюйте правильно вашу бібліографію.

1

Leask, J. "Understanding Immunisation Controversies." Thesis, The University of Sydney, 2002. http://hdl.handle.net/2123/12503.

Повний текст джерела
Анотація:
BACKGROUND: Mass childhood vaccination has had a profound impact on reducing morbidity and mortality from a number of infectious diseases. Ironically, as vaccine preventable diseases become less common and so less visible to the public, greater attention is afforded to vaccine risks. In the UK, Japan, France and the USA, controversies about the safety of vaccines have led to declining public confidence in the practice which, at times, has lowered immunisation rates, leading to disease outbreaks and deaths. Public health workers are often perplexed at how to respond in such situations. In order to plan effective communication strategies it is necessary to understand how controversies about vaccine safety escalate. This thesis describes the nature of public controversies about vaccine safety by examining the discourses of the anti-vaccination lobby, the mass media, parents and health professionals. THE ANTI-VACCINATION MOVEMENT: This thesis first explores the activities of the anti-vaccination movement and their efforts to disseminate their core messages to the wider public. In Australia, the anti-vaccination lobby are a largely unseen force in sustaining controversies about vaccine safety. This small but vocal movement are well organised and strategic. A description of their activities in Australia demonstrates the comprehensiveness of their efforts to oppose vaccination at the political, community and mass media level. THE NEWS MEDIA: The news media have the potential to influence public perceptions about childhood vaccination. To complement previous research on the nature of anti-vaccination reportage, this thesis examines positive coverage from four and a half years of newsprint articles about immunisation published in Australian newspapers. Located at the core of anti-vaccination discourse is an appeal to an individualistic ideology that upholds vigilance against the erosion of civil liberties, suspicion of authority figures and the back-to-nature idyll. By contrast, pro-vaccination rhetoric is centred on notions of threat from personified and malevolent infectious disease and vaccines as saviours and modern medical miracles. PARENTS AND VACCINE SAFETY: Focus groups with new mothers explore how they deconstruct competing messages about vaccine safety, using vignettes from broadcast media. Results suggest that anti-vaccination claims are most potent when they come from medical sources and/or include stories and images of allegedly vaccine-damaged children. Mothers apply complex assessments of risk and benefit in their decision-making and draw on analogies to explain their position. Trust in vaccine providers, personal experiences with vaccine preventable diseases, the advice of family and friends, and scepticism about the media as a source of information are important in decision making. Implicit in attempts to counter negative publicity are assumptions that factual information about disease and vaccines will alone reassure parents. However, when their support for vaccination is challenged, mothers are more likely to mobilise images of children with vaccine preventable diseases than numerical assessments of risk and benefit. More generally, parental support of vaccination is sustained by recourse to normative beliefs and the desire to follow convention. Parents also have an underlying desire to actively protect their children from diseases that are dreaded. VACCINATION PROVIDERS: Their encounter with vaccine providers is fundamental to parental decision making and negotiation of conflicting messages about vaccination. An interview study with doctors incorporating simulated scenarios explores how doctors address parental concerns about vaccination in the clinical encounter. In this study, doctors acknowledge a mother’s concerns, tailor their discussion to the individual circumstance of the mother and convey the notion of choice. They attempt to compare vaccine and disease risks using mainly qualitative estimates of disease and adverse event incidence. Possibly less helpful aspects of the encounters are when doctors became adversarial, discredit a mother’s source of information, ask hypothetical “how would you feel if…” questions, over-use scientific language, enter into games of scientific ping pong or give bland “you’re wrong” statements. Doctors face difficulty when communicating with patients whose paradigms are diametrically opposed to their own. Influencing these encounters is their underlying relationship with the patient, messages from the mass media and theories that help guide the doctor’s communication efforts. THE MODEL: This thesis proposes a model for how vaccine controversies can lead to sustained declines in vaccination rates. This is achieved through highlighting the above perspectives and examining the current controversy over the combined measles, mumps, rubella vaccine and it’s unsupported link to autism. It suggests that vaccine safety concerns ‘catch fire’ when the source of a controversy is trusted, seen as expert and coming from a prestigious body or publication. Greater potency is gained when vaccines are implicated as the cause of a dreaded condition and when the link has some biological plausibility face value. Moving personal testimony about allegedly vaccine-damaged children can eclipse official attempts to provide factual reassurances which, by comparison, appear bland and uncompelling. Finally, a less acknowledged but possibly more important factor is the erosion of confidence among health professionals and confusion at the level of service delivery where upstream changes can have exponential effects.
Стилі APA, Harvard, Vancouver, ISO та ін.
2

Jones, Megan. "Immunisation : a discourse analytic study /." Title page, abstract and contents only, 1998. http://web4.library.adelaide.edu.au/theses/09PM/09pmj78.pdf.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
3

Clegg, Andrew J. "Childhood immunisation uptake : geographical perspectives." Thesis, University of Portsmouth, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332849.

Повний текст джерела
Анотація:
Efforts to control and eradicate infectious disease have concentrated on the provision of childhood vaccination. Unfortunately, the uptake of childhood vaccination continues to vary and infectious diseases continue to cause differential morbidity and mortality. Limited research has assessed the factors that underlie the uptake of vaccination. The present research undertakes an analysis of the patterns and determinants of vaccination uptake within the Portsmouth and South East Hampshire Health Authority, located in the south of England. In so doing, the research employs different analytical approaches, from the traditional ecological analysis through descriptive mapping and multivariate regression, to the innovative multi-level analyses. The ecological analysis shows a distinct geography to the uptake of vaccination which reflects characteristics of socioeconomic deprivation. Further analysis through multilevel modelling, emphasizes two influences on the uptake of vaccination. First, parental characteristics, which affect their role as decision maker and their ability to overcome certain time-space constraints to attend. Second, the ways in which the service is provided, including the influence of the health professional as adviser and provider of vaccination and the initiatives employed to improve uptake. These findings have implications for the future provision of childhood vaccination. Specifically, the research provides the opportunity to identify and target children unlikely to complete their vaccination schedule and the need to improve and standardise health professional knowledge and advice to parents.
Стилі APA, Harvard, Vancouver, ISO та ін.
4

Carpenter, Zoe Karen. "Novel immunisation strategies against Salmonella." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/13319.

Повний текст джерела
Анотація:
This thesis presents two novel immunisation strategies against Salmonella enterica serovar Typhimurium (S. typhimurium) in the mouse model. Firstly, mice immunised with multiple antigens in the form of a DNA vaccine have been shown to develop specific humoral and cellular responses to proteins encoded within the vaccine. Secondly, it has been shown that immunisation with multiple cytosolic antigens (CA) of S. typhimurium SL1344, formulated with the adjuvant dimethyl dioctadecyl ammoniumbromide (DDA), induces strong humoral and cellular responses. These responses have been characterised, and their ability to confer protection on mice challenged with a lethal dose of S. typhimurium SL1344 has been investigated. The aim of DNA vaccination is to induce immune responses to protein antigens expressed in vivo by injection plasmid DNA encoding the antigen sequence. Expression library immunisation (ELI) is a new technique that draws on DNA immunisation and can be developed to identify the key antigens of a pathogen that confer protection. ELI has previously been used in a number of disease models in mice and has been used in this thesis as a means of inducing immune responses against an unspecified subset of bacterial antigens. An expression library (EL) of S. typhimurium SL1344 was constructed using a mammalian expression vector encoding EGFP. The expression of S. typhimurium SL1344 antigens forming fusion proteins with EGFP was visualised as green fluorescence in mouse fibroblast cells in vitro. The EL consisted of 140,000 clones of which 14,000 were used for immunisation. The library was administered to both BALB/c and CBA mice to examine the effect of mouse strain and was administered both intradermally (ID) and intramuscularly (IM) to examine the effect of immunisation route. Analysis by Western blot and ELISA showed that humoral responses were induced in both BALB/c and CBA mice. ID and IM inoculation produced similar results in BALB/c mice. Responses included a significant Thl component as judged by the presence of IgG2a in the serum and the secretion of IFN-γ when T cells from peripheral lymph nodes were stimulated by CA in culture.
Стилі APA, Harvard, Vancouver, ISO та ін.
5

CHABANNIER, MARIE-HELENE. "Immunisation anti-okt3 : aspects methodologiques." Toulouse 3, 1994. http://www.theses.fr/1994TOU31569.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
6

Scholz, Kirsten [Verfasser]. "New immunisation strategies via mucosal routes : comparative analysis of sublingual, intravaginal and intranasal immunisation / Kirsten Scholz." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2012. http://d-nb.info/1026933870/34.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
7

Harvey, Hannah Louise. "The role of the care-giver in infant immunisation : influences and perspectives on immunisation uptake and pain expression." Thesis, Durham University, 2016. http://etheses.dur.ac.uk/11427/.

Повний текст джерела
Анотація:
The recent decline in early childhood vaccination has been attributed to negative parental attitudes about immunisation. Vaccinations are a common cause of acute infant pain, although the impact of infant pain expression upon vaccination uptake is not well understood. Theoretical models of infant pain propose that care-giver behaviours may regulate pain expression, although previous findings have been inconclusive. Understanding care-giver beliefs, and the relationship between care-giver and infant behaviours during immunisation, may help to identify effective soothing strategies and develop interventions targeting parental concerns. This thesis examines a number of factors associated with the role of the care-giver in infant immunisation uptake and pain expression. First, two systematic reviews, summarise evidence regarding the efficacy of uptake interventions and parental beliefs about immunisation. Second, the relationship between infant pain expression, care-giver behaviour and vaccine uptake is explored using a prospective cohort study. Finally, the hierarchical nature of parental viewpoints and their relation to vaccine uptake is examined using Q-methodology. Whilst care-givers determine immunisation uptake, findings from the thesis suggest that their influence on infant pain expression may be minimal. Instead, the speed at which vaccines are administered, and the offer of a pacifier during injections may reduce pain expression. Whilst parents have complex views about vaccination, the views of immunising parents are dominated by the notion that vaccination provides the best protection from disease. Implications of the findings are discussed in terms of clinical practice, vaccine policy and future interventions promoting confidence in vaccine efficacy to target vaccine-hesitancy.
Стилі APA, Harvard, Vancouver, ISO та ін.
8

Tadich, N. A. "Studies on immunisation of ewes and lambs." Thesis, University of Liverpool, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370843.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
9

Dahlan, Afendi. "Needle-less skin immunisation using low-frequency ultrasound." Thesis, University College London (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520745.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
10

Gould, Myles I. "Multilevel modelling of geographical variations in immunisation uptake." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296694.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
11

Forster, A. S. "The human papillomavirus immunisation programme and sexual behaviour." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1301995/.

Повний текст джерела
Анотація:
The introduction of human papillomavirus (HPV) vaccination has caused some parents to report concern that their daughters may change their sexual behaviour following vaccination. This concern consistently relates to vaccination acceptance, but had not been investigated in detail. Accordingly, five studies addressed the thesis objective: to explore parents’ concern about adolescent sexual behaviour following HPV vaccination in the context of the UK immunisation programme and to examine whether such concerns were justifiable. The first study examined discussions of risky sexual behaviour and HPV vaccination in news articles published over five years in British newspapers. The second study investigated mothers’ concern about their daughters engaging in risky sexual behaviour after vaccination by questioning a sample of mothers. The third study explored whether adolescents would interpret vaccination consent from parents as carte blanche approval for sexual activity, by surveying 162 girls. The fourth study prospectively investigated the impact of HPV vaccination and a fifth study compared differences between vaccinated girls and girls who had not been offered the vaccine. Concern about the impact of HPV vaccination on sexual behaviour was raised and countered in the media. A minority of mothers were apprehensive about girls’ sexual behaviour following vaccination, however these concerns did not relate to vaccine acceptance. Before the vaccination programme was introduced, some adolescents would infer implicit consent to sexual activity if their parents were to consent to vaccination but most would also take positive messages. Once the HPV immunisation programme was underway, girls’ sexual behaviour did not become more negative following vaccination, despite perceptions of risk lowering. Parents’ concerns may have resulted in reluctance to discuss sex with their daughters in the context of HPV vaccination so that implicit messages of approval for sexual activity are not conveyed. Risk perceptions were pertinent in HPV vaccination acceptability and when exploring behaviour change. These findings may help reduce resistance to HPV vaccination. Implications for theory and practice are discussed.
Стилі APA, Harvard, Vancouver, ISO та ін.
12

Johnston, Louise. "Transcutaneous immunisation with antigens derived from tetanus toxin." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/4657.

Повний текст джерела
Анотація:
Transcutaneous immunisation (TCI) is a novel needle-free method of vaccine delivery, which involves the application of soluble antigens onto the surface of intact skin. In this thesis, the immunogenicity and neutralising potency of tetanus neurotoxin (TeNT) fragments were compared to that of tetanus toxoid (TTxd) following TCI. In addition, to understand the mechanisms of induction of immune response by TCI, in vitro and in vivo interaction of tetanus proteins with skin immune cells was also investigated. The 50kDa recombinant carboxyl-terminal fragment of tetanus toxin (HCWT) and a 50kDa HC mutant(HCM115) which is devoid of neuronal binding properties, were expressed and purified by affinity chromatography, and excess endotoxin removed by size exclusion chromatography. Mice immunized with HCWT, in the absence of adjuvant, induced the highest anti-toxoid and anti-HCWT antibody titers, with significant increases in the toxin neutralising antibody response when compared with TTxd. In vitro studies demonstrated that both HC fragments and TTxd were capable of up regulating the surface expression of activation marker ICAM-1 on murine bone-marrow derived dendritic cells (DC), but not on the human keratinocyte cell line HaCaT. Real-time reverse transcriptase-PCR (RealtimeRT-PCR) analysis showed that TNF-α expression was up regulated in vivo as early as 10 minutes following TCI, and this was caused by shaving rather than by tetanus proteins themselves. Immunohistochemistry staining to monitor the translocation of HCWT fragment and TTxd through the skin following TCI showed that HCWT protein could be detected in both the epidermis and dermis within four hours post-application. However, TTxd translocation appeared to be much slower in comparison. Collectively, the results presented in this thesis suggest that TCI may provide an opportunity for effective delivery of toxin-like antigens, which harbor protective epitopes and that traditional toxoid proteins may not be optimal antigens for skin immunisation.
Стилі APA, Harvard, Vancouver, ISO та ін.
13

Gallagher, J. D. "Gregarious immunisation in the mealworm beetle, Tenebrio molitor." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/12275/.

Повний текст джерела
Анотація:
Investment in immunity is costly: one way in which hosts can ameliorate these costs is through immune priming, whereby hosts develop increased protection to future infection following previous exposure to a parasite or immune elicitor. Priming offers hosts a more efficient way of managing immune insult by allowing for a stronger and faster response to an immune insult. As well as investing in physiological immune defences, hosts can also leverage behavioural responses to reduce the costs of infection. Group-living in insects offers several benefits, such as predator avoidance. However, it can be costly in terms of increasing the risks of exposure to parasites. Group facilitation of disease resistance through a variety of processes collectively known as 'social immunity' is well established in the eusocial insects. Many gregarious insects share several features of their ecology with eusocial species, and should thus be predisposed to many of the same risks of infection, and the same evolved processes that mitigate these risks. A form of immune priming known 'social immunisation' has recently been described in eusocial insects, whereby immunologically naïve individuals exhibit enhanced immunity against infection after being housed with infected nestmates. Whether similar mechanisms exist in gregarious but non-social insects is unknown, and it is this premise that forms the conceptual basis of this thesis. I investigated whether a non-social but gregarious insect, the mealworm beetle (Tenebrio molitor), altered its immune investment following cohabitation with an immunestimulated conspecific. I examined the potential role of both physiological and behavioural defences in offering prophylactic protection against perceived pathogenic threat. I also investigated the potential mechanisms of such an form of immunisation by examining immune responses induced by cohabitation with conspecifics challenged by a live (and transmissible) bacterial infection and those challenged by either heat-killed bacteria or an artificial antigen (both non-transmissible). Finally, I examined the role of host behaviour in affecting immunisation, quantifying behavioural changes in immune-stimulated hosts (referred to as 'sickness behaviours') to try and identify visual or behavioural cues which may be utilised by naïve hosts to stimulate prophylactic defences, There was no robust evidence for a parsimonious process of gregarious immunisation. However, there were differences between the sexes in their immune responses to infection threat, as well as in their induction of sickness behaviours following infection. Whilst there was little evidence for an upregulation of immunity in naïve females, females appeared to exhibit enhanced tolerance of infection following cohabitation with a 'sick' conspecific, as they suffered no decrease in longevity despite the presence of relatively high parasite loads. Males showed the opposite pattern to that predicted by gregarious immunisation, decreasing their investment in physiological defence following exposure to 'sick' conspecifics. Despite finding no clear evidence for enhanced resistance through a straightforward process of gregarious immunisation, these data suggest that naïve T. mollitor may be able detect social cues of infection produced by parasitised conspecifics. I propose that the immune responses displayed by both males and females constitute tolerance strategies which help hosts to minimise the costs of parasitism. Due to intrinsic differences in the life-history trajectories of the sexes, females are predicted to invest in immunological tolerance mechanisms aimed at self-preservation in order to preserve their capacity for future reproduction, whereas males are predicted to terminally invest in reproduction in order to maximise their fitness.
Стилі APA, Harvard, Vancouver, ISO та ін.
14

Elayeb, Rahma. "Étude des mécanismes de l'allo-immunisation post-transfusionnelle." Thesis, Paris Est, 2016. http://www.theses.fr/2016PESC0076.

Повний текст джерела
Анотація:
La transfusion sanguine est un traitement essentiel à la survie de millions de patients. Son principal risque immunologique est l’allo-immunisation post-transfusionnelle. Elle se traduit par la production d’allo-anticorps contre des antigènes de globules rouges (GR) conduisant à des hémolyses post-transfusionnelles. Les mécanismes à l’origine de la tolérance des GR ou de son inhibition lors de l’allo-immunisation sont mal connus. Ainsi, mes travaux de thèse, portant sur la compréhension de ces effets, se sont articulés en trois parties avec 1/ l’étude des conditions optimales aux réponses allo-immunes, 2/ l’étude des effets d’une stratégie thérapeutique utilisant un anticorps monoclonal et 3/ l’étude des effets immunomodulateurs, incluant la tolérance, médiée par des composants présents dans les concentrés de globules rouges (CGR).Afin d’étudier l’allo-immunisation, nous avons utilisé le modèle murin. Nous montrons qu’une variation du délai entre la transfusion et la stimulation du TLR3 impacte la réponse immune dans la rate. Une activation importante des lymphocytes T CD4+ (LT CD4+) allo-réactifs accompagnée d’une production accrue d’allo-anticorps ont été montrées à 7 jours de délai. Afin de limiter l’allo-immunisation, l’utilisation d’un anticorps anti-CD20 déplétant les lymphocytes B (LB) montre une altération des LB mais surtout des LT CD4+ impliqués dans le processus d’induction de l’allo-immunisation. Enfin, la modification du phénotype des cellules dendritiques CD11c+ de la rate des souris transfusées, observée hors contexte inflammatoire, suggère une maturation incomplète à l’origine d’une tolérance antigénique. Pour finir, l’analyse de différents composants présents dans les CGR confirme l’existence de microparticules (MPs) lymphocytaires. Ces MPs présentent des molécules inhibitrices et pourraient donc être impliquées dans la tolérance des antigènes transfusés.En conclusion, mes travaux montrent la coopération des DCs avec les LT CD4+ permettant celle des LT CD4+ avec les LB pour induire une réponse immune. Comme toute réponse humorale, nous confirmons que l’allo-immunisation fait intervenir des DCs, des LT CD4+ et des LB. Ces résultats ouvrent de nouvelles voies de recherche pour mieux caractériser l’allo-immunisation en particulier chez les patients drépanocytaires qui sont les plus touchés
Red blood cell (RBC) transfusion is a life-saving treatment for millions of patients. However, its main immunological risk is RBC alloimmunization resulting in antibody production against RBC antigen. Alloimmunization can lead to severe complications threatening the life of the patient. The mechanisms explaining RBC alloimmunization are poorly understood. Therefore, my doctoral work aiming at understanding transfusion effects, was subdivided into three parts with 1/ the study of optimal conditions for alloimmune responses, 2/ the impact of a therapeutic strategy using a monoclonal antibody to inhibit alloimmunization and 3/ the study of immunomodulatory effects of transfusion, including tolerance, through components present in the RBC concentrates.We also used HOD murine model for the study of alloimmunization to show an impact of the delay between the TLR3 agonist injection and the transfusion on immune responses against RBCs. At 7 days of delay, we have demonstrated an important alloreactive CD4+ T-cell activation and a wider alloantibody production. Furthermore, B-cell depletion, using a monoclonal anti-CD20 antibody, revealed potential changes on LB implicated in alloimmunization induction and mostly on alloreactive CD4+ T cells. We finally observed a modification of splenic CD11c+ DC phenotype from transfused mice out of a TLR context. This suggest an incomplete maturation that could explain antigen-specific tolerance. The investigation of several components in RBC concentrates confirmed the presence of microparticules (MPs) issued from T lymphocytes. These MPs carry inhibitory markers and could thus inhibit DC activation to induce antigen-specific tolerance.Therefore, my doctoral work highlights the implication and the cooperation of DCs with CD4+ T cells to allow cellular cooperation between CD4+ T cells and B cells for immune response induction. As in any humoral response, we confirmed that RBC alloimmunization involves DCs, CD4+ T cells and B cells. In addition, these results are opening up new areas of investigation for a better characterization of alloimmunization in particular in the most affected patients, the SCD patients
Стилі APA, Harvard, Vancouver, ISO та ін.
15

Casswall, Thomas. "Passive immunisation as therapy for gastrointestinal infections in children /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3862-8/.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
16

Al-Jabban, T. M. T. "Factors influencing immunisation uptake in childhood in Saudi Arabia." Thesis, Swansea University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.635685.

Повний текст джерела
Анотація:
The present research aims to study the postnatal care services in Saudi Arabia. It is designed to determine the factors that influence the pattern of immunisation uptake in childhood at immunisation clinics in Primary Health Care Centres (PHCCs) in the Madinah Area. The study covers the Madinah Area (Western Region), which showed, according to published MOH reports, the lowest immunisation coverage by all vaccines (Farag et al., 1995). A survey study of 503 children (1006 Parents), representing 6% of the total study population, was conducted in 24 PHC Centres, which represent 30% of the total number of PHCCs in the study area. These Centres were chosen from all eight regions of the Madinah Area. The sampling method used in this study was Multistage Cluster Sampling, with probability proportional to size technique (PPS). The face-to-face interview survey, using a structured questionnaire, was chosen as the preferred mode of data collection. The survey showed that 67.6% of the total children surveyed were fully immunised, Out of this figure, 46.1% were immunised on time, while 21.5% were fully immunised, but not on time. 25.4% were partially immunised and 7.0% were not immunised. In addition, a variety of factors were shown to have a significant influence on the child's immunisation status. More specifically, place of residence, distance to the PHC Centre, availability of the vaccination card, accommodation type, waiting time at the immunisation clinic and evaluation of the facilities in the clinic are the six major factors that explain why immunisation does not occur. The results also indicated several other demographic, socio-economic, parent-related and clinic-related variables that have a significant influence on the child's immunisation status.
Стилі APA, Harvard, Vancouver, ISO та ін.
17

Cahill, Edward Sean. "Antigen delivery systems for nasal immunisation against B. pertussis." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321455.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
18

Scott, Susana. "The impact of HIV on measles and measles immunisation." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439504.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
19

Zuckerman, Jane Nicola. "Prevention of viral hepatitis A and B by immunisation." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336638.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
20

Tan, Tiong Kit. "Development of viral vectors for passive immunisation against influenza." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:54fd7396-f09a-46e5-952e-95a1f5449326.

Повний текст джерела
Анотація:
Seasonal influenza is a major global health threat causing more than 500,000 deaths annually. Pandemic influenza can arise through antigenic shift, or when novel influenza strains escape from animal reservoirs, and can affect a large geographical area leading to a large number of deaths. Neither prior infection, nor current vaccines, provide lasting protection due to the rapid antigenic evolution of influenza virus. The discovery of broadly neutralising antibodies (bnAbs) against influenza has opened the possibility of passive immunisation, which could provide protection against multiple influenza strains. Passive immunisation by parenteral administration of purified antibody is challenging, hindered by high antibody production costs and the short half-life of antibody in the circulation leading to relatively transient protection; however the use of viral vectors to deliver bnAbs can begin to address these limitations. Studies presented in this thesis investigated the feasibility of a novel, lung-targeting lentiviral vector pseudotyped with the fusion (F) and haemagglutinin-neuraminidase (HN) coat proteins from Sendai virus (rSIV.F/HN) as a gene transfer agent for bnAb expression. Recombinant SIV.F/HN vector expressing a secreted reporter protein Gaussia luciferase showed expression in the mouse lung lumen 1 month after lung administration. A single dose of rSIV.F/HN encoding novel anti-influenza bnAb (T1-3B) in a single Open Reading Frame directed expression of T1-3B into the lung lumen and systemic circulation, and conferred partial protection against lethal influenza challenge. Intramuscular (IM) delivery of a recombinant adeno-associated virus vector (rAAV2/8), previously reported to be effective against influenza challenge in mice, directed levels of T1-3B that conferred complete protection against influenza challenge. Daily repeat administrations of rSIV.F/HN did not improve protection against influenza challenge, but the ability of this vector to be repeatedly administered without loss of efficacy may be an advantage in potential clinical applications. Engineering of the bnAb, into the IgA1 backbone greatly enhanced the potency of several bnAbs and might improve influenza protection mediated by rSIV.F/HN. In conclusion, prophylaxis provided by gene transfer during an influenza pandemic might be feasible, providing long-lasting, more cost-effective and time-responsive protection than traditional vaccines or parenteral administration of therapeutic antibody.
Стилі APA, Harvard, Vancouver, ISO та ін.
21

Al, Sebea Hussain. "Dynamic detection and immunisation of malware using mobile agents." Thesis, Edinburgh Napier University, 2005. http://researchrepository.napier.ac.uk/output/4036/.

Повний текст джерела
Анотація:
At present, malicious software (mal-ware) is causing many problems on private networks and the Internet. One major cause of this includes outdated or absent security software to countermeasure these anomalies such as Antivirus software and Personal Firewalls. Another cause is that mal-ware can exploit weaknesses in software, notably operating systems. This can be reduced by use of a patch service, which automatically downloads patches to its clients. Unfortunately this can lead to new problems introduced by the patch server itself. The aim of this project is to produce a more flexible approach in which agent programs are dispatched to clients (which in turn run static agent programs), allowing them to communicate locally rather than over the network. Thus, this project uses mobile agents which are software agents which can be given an itinerary and migrate to different hosts, interrogating the static agents therein for any suspicious files. These mobile agents are deployed with a list of known mal-ware signatures and their corresponding cures, which are used as a reference to determine whether a reported suspect is indeed malicious. The overall system is responsible for Dynamic Detection and Immunisation of Mal-ware using Mobile Agents (DIMA) on peer to peer (P2P) systems. DIMA is be categorised under Intrusion Detection Systems (IDS) and deals with the specific branch of malicious software discovery and removal. DIMA was designed using Borland Delphi to implement the static agent due to its seamless integration with the Windows operating system, whereas the mobile agent was implemented in Java, running on the Grasshopper mobile agent environment, due to its compliance with several mobile agent development standards and in-depth documentation. In order to evaluate the characteristics of the DIMA system a number of experiments were carried out. This included measuring the total migration time and host hardware specification and its effect on trip timings. Also, as the mobile agent migrated, its size was measured between hops to see how this varied as more data was collected from hosts. The main results of this project show that the time the mobile agent took to visit all predetermined hosts increased linearly as the number of hosts grew (the average inter-hop interval was approximately 1 second). It was also noted that modifications to hardware specifications in a group of hosts had minimal effect on the total journey time for the mobile agent. Increasing a group of host's processor speeds or RAM capacity made a subtle difference to round trip timings (less than 300 milliseconds faster than a slower group of hosts). Finally, it was proven that as the agent made more hops, it increased in size due to the accumulation of statistical data collected (57 bytes after the first hop, and then a constant increase of 4 bytes per hop thereafter).
Стилі APA, Harvard, Vancouver, ISO та ін.
22

Chavarin, Notin Patricia. "A propos d'un cas d'allo-immunisation foeto-maternelle plaquettaire." Saint-Etienne, 1993. http://www.theses.fr/1993STET6201.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
23

Abdullahi, Leila Hussein. "Adolescent immunisation in Africa in the decade of vaccines." Doctoral thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/30364.

Повний текст джерела
Анотація:
Rationale: There are many public health benefits of targeting adolescent for immunisation. However, and in many settings, adolescents do not get optimal benefits from immunisation. In the decade of vaccines (2011-2020), adolescent immunisation is a topical subject. An up-to-date and synthesized research on adolescent immunisation is lacking. Overall purpose: The purpose of the PhD thesis was to characterize adolescent immunisation in the decade of vaccines. Research methods: First, we conducted a comprehensive narrative review of the literature (chapter 2) on adolescent immunisation. Then, we conducted systematic reviews (chapters 3 and 4). One of the systematic reviews assessed the strategies to improve uptake of vaccines among adolescents. The other systematic review assessed the knowledge, attitudes and practices of adolescents and their parents and teachers towards immunisation. Finally (chapter 5), we conducted a cross-sectional study to describe the challenges experienced, and lessons learnt during the introduction of national human papillomavirus (HPV) vaccination programmes in Africa. Findings: Adolescents are an important group to target with primary, booster or catch up immunisation. Some global initiatives have advocated for adolescent immunisation. Multiple reasons, among them, lack of knowledge and access to immunisation services are barriers to adolescent immunisation. There exist multiple strategies to improve uptake of vaccines among adolescents. For example, health education, financial incentives, mandatory vaccination, and class-based school vaccine delivery. The evidence suggests that a combination of strategies may be more effective than one strategy alone in enhancing uptake of vaccines by adolescents. Knowledge of vaccines, immunisation and vaccine preventable diseases was found to be suboptimal among key stakeholders of adolescent immunisation in Africa. We found a disconnect between the level of knowledge on immunisation and the uptake of vaccines, an interesting finding that warrants further research in Africa. Six African countries shared the lessons learnt and experiences during the national introduction of HPV vaccination programmes that targeted adolescent girls. There were similarities in the results among the participating countries. The challenges included: logistical coordination, identification of the target population, obtaining political support, integration with other school programmes and stakeholder engagement. A lesson learnt was that schools are a convenient site to access and vaccinate adolescents. Conclusion: Adolescent immunisation is not routinely practiced in many countries. The introduction of HPV vaccines has created an ideal opportunity to build platforms for adolescent immunisation. Research on adolescent immunisation is limited, more so in low and middle-income countries. Existing research shows a combination of strategies can be used to enhance uptake of vaccines among adolescents. Strong advocacy programmes are required to drive the global agenda of adolescent immunisation, particularly in Africa.
Стилі APA, Harvard, Vancouver, ISO та ін.
24

Wiysonge, Shey Umaru Charles. "Building evidence for improving childhood immunisation coverage in Africa." Doctoral thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/3183.

Повний текст джерела
Анотація:
Includes abstract.
Includes bibliographical references.
The Expanded Programme on Immunisation has the potential to substantially reduce child mortality and contribute to achieving the Millennium Development Goals. We assessed the programme’s performance in Africa, the reasons for poor performance, and effective interventions for improving its performance on the continent. We used a combination of methods including systematic reviews, bibliometric analyses, generalised linear models, and grading of the quality of evidence. We found that African countries have made extraordinary advances since childhood immunisation programmes began in 1974. However, there exist wide inter-country and intra-country differences, and the quality of immunisation data is poor. Besides, vaccines are administered well after the recommended ages in many countries; leaving children exposed to deadly vaccine-preventable diseases for long periods. In addition, Africa’s contribution to the global immunisation research output is minimal. There is no association between research productivity and immunisation coverage in Africa, which may signal lack of interactive communication between policymakers and researchers. Furthermore, individual and contextual factors (defined at community and country levels) are independently associated with low immunisation coverage; suggesting that immunisation system strengthening should address people and the communities and societies in which they live. Lastly, we found moderate-to-high quality evidence that interactive educational meetings, audit and feedback, supportive supervision; and use of community health workers, parent reminders, home visits, interactive communication, mass media, and material incentives have the potential to improve childhood immunisation coverage in Africa.
Стилі APA, Harvard, Vancouver, ISO та ін.
25

Kimera, Sharadhuli I. "Methods for the design and evaluation of East Coast fever (ECF) control strategies." Thesis, University of Reading, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242338.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
26

Borus, Peter Kimutai. "Measles vaccination in Kenya : determination of vaccine coverage, determinants of receipt of vaccination and the quality of immunisation services in slum areas of Nairobi." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289764.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
27

Bonnet, Françoise. "Allo-immunisation foeto-maternelle dans le systeme rhesus : proposition d'un score predictif de l'atteinte foetale." Toulouse 3, 1988. http://www.theses.fr/1988TOU31037.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
28

Schöneck, Ralf. "Clonage et caractérisation moléculaire d'un ADNc de trypanosoma cruzi codant pour une protéine homologue aux glutathion s-transferases : approche fonctionnelle." Lille 1, 1994. http://www.theses.fr/1994LIL10044.

Повний текст джерела
Анотація:
Au cours de ce travail, nous avons clone et caracterise une adnc (tcac2) de trypanosoma cruzi qui code pour une proteine homologue aux proteines de stress de faible poids moleculaire et aux glutathion s-transferases. Cette homologie de sequence a ete renforcee par des analyses comparatives des profiles d'hydropathie et des structures secondaires (hca). De plus, la proteine native correspondante du stade epimastigote a ete purifiee sur une colonne d'affinite avec le s-hexylglutathion comme matrice et sequencee directement afin de prouver l'identite. Un serum dirige contre la proteine de fusion sj26gst/tcac2 (anti tcac2) reconnait dans les differents stades parasitaire de t. Cruzi, un seule antigene de 52 kda ayant un phi de 5,4. Cependant, aucun messager n'est detecte dans les formes trypomastigotes. La proteine tcac2, exprimee par le stade amastigote, semble persister apres la differenciation des formes amastigotes en formes trypomastigotes. Par ailleurs, l'expression de cette proteine augmente avec l'age et la densite de la culture epimastigote in vitro. La proteine tcac2 fait partie des composants d'excretion/secretion du parasite. Des antigenes portant une reactivite croisee ont ete detectes par le serum anti-tcac2, dans les differentes souches de t. Cruzi et les especes de t. Rangeli et t. Marinkelli. L'adnc obtenu par recouvrement (1648 pb), a partir de l'insert tcac2 et la region 5 obtenue par 5racepcr, revele un cadre de lecture ouvert codant pour une proteine d'environ 51 kda. Cependant, la taille du messager detecte en northern-blot est de 2500 bases pour t. Cruzi. D'une facon interessante, t. Marinkelli possede deux messagers de 1700 et de 2300 bases. Par ailleurs, l'immunisation de souris a l'aide de la proteine de fusion sj26gcst/tcac2 protege partiellement contre l'infection experimentale par t. Cruzi.
Стилі APA, Harvard, Vancouver, ISO та ін.
29

Dinan, Leonie Rita. "Antibody responses after Hib immunisation in premature and term infants /." Title page, table of contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09MPM/09mpmd583.pdf.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
30

Creusot, Remi Jerome. "Particle-mediated DNA immunisation : CD+T cell priming and cooperation." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399172.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
31

Laing, Gavin. "The use of liposomes for immunisation against Echis carinatus venom." Thesis, University of Liverpool, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317199.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
32

Mcshane, Helen Irene. "Immunisation strategies for enhancing T cell responses against M. tuberculosis." Thesis, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271722.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
33

Dhanoya, A. S. "Characterisation of plasmid DNA complexes for application in genetic immunisation." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1357937/.

Повний текст джерела
Анотація:
Non-viral gene delivery into mammalian cells is widely used in bio-processing for the production of recombinant proteins as well as considered for clinical trials in gene therapy and vaccination. DNA can be delivered through various non-viral methods including polymers, lipids, peptides and entrapment within nanoparticles. Non-viral gene delivery often entails nucleic acids that are bound to a polymer or polycation to form a complex referred to as polyplexes. Various factors may affect the efficiency of polyplex uptake in mammalian cells. One factor is DNA topology, which is important from a regulatory perspective whereby FDA guidelines require the majority of plasmid DNA (pDNA) (>80%) to be in its supercoiled (SC) form. Therefore the motivation of this study was to investigate the impact of DNA topology on non-viral gene delivery. In this study pDNA (6.8kb) was complexed with poly-L-lysine (PLL) (MW, 9600) to form PLL/DNA polyplexes. pDNA of three topologies; SC, open circular (OC) and linear-pDNA were complexed with PLL. Biophysical analyses which included size, surface charge, DNA binding and nuclease resistance assays revealed topology dependent results. For example SCpDNA polyplexes were smaller (<140nm); more efficiently packaged and displayed greater nuclease resistance than OC- and linear-pDNA polyplexes. DNA release from PLL was analysed although such experiments were not a time course study, rather a confirmatory assay to identify PLL-bound DNA. Polyplex uptake in Chinese hamster ovary (CHO), HeLa and dendritic cells (DCs) were studied. Uptake was monitored by fluorescent confocal microscopy, flow cytometry and reporter gene expression assays. Regardless of cell type, complexes containing SC-pDNA displayed greater reporter gene expression than OC- and linear-pDNA polyplexes. In regards to CHO cells confocal image analysis revealed SC-pDNA polyplexes associated most efficiently with host cell nuclei. SC-pDNA polyplexes were smaller and nuclease resistant than its counterparts which may facilitate uptake. Endocytic mechanisms of uptake were analysed in CHO cells. This is important as knowledge of polyplex uptake pathways could be exploited for future gene delivery studies. Polyplex nuclear import was studied in regards to importin-7 (Imp7). Imp7 is key nuclear import receptor identified in previous studies, which was a preselected candidate. Gene expression studies along with qualitative and quantitative confocal microscopy analyses indicated possible exploitation of Imp7. However live cell imaging experiments showed colocalisation between DNA and nuclei fluorescence in Imp7 KD cells which suggests other routes of nuclear import may be employed. Polyplex uptake in DCs was also studied as these are key sentinels of the immune system. SC-pDNA polyplexes displayed the most efficient uptake and gene expression profiles in DCs. Gene expression and ability to induce DC phenotypic changes was dependent on dosage and DNA topology. Therefore this study stresses the importance of DNA topology which impacts on the bio-processing of non-viral gene delivery products.
Стилі APA, Harvard, Vancouver, ISO та ін.
34

Matthews, Zoe. "Child immunisation programmes in developing countries : assessing the demographic impact." Thesis, University of Southampton, 1993. https://eprints.soton.ac.uk/34278/.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
35

RIPOLL, PATTE CHRISTINE. "Allo-immunisation plaquettaire foeto-maternelle : a propos d'une famille informative." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20348.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
36

Corrigall, Joanne. "Immunisation coverage of the Western Cape Province : household survey 2005." Master's thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/9318.

Повний текст джерела
Анотація:
Includes bibliographical references.
[Objective] To determine the routine immunisation coverage rates in children aged 12-23 months in the Western Cape and factors affecting immunisation coverage. [Design] Cross-sectional Household Survey using an adaptation of the '30x7' cluster survey technique (multi-stage sampling). [Setting] Households across the Western Cape. [Subjects] 3705 caregivers of children aged 12-23 months who had been living in the Western Cape for at least 6 months. [Outcome Measures] Vaccination Status (1=fully vaccinated, 0=partially vaccinated) as recorded on a Road to Health card or given by history. Factors affecting caregivers' vaccination behaviour established from a questionnaire. [Results] The immunisation coverage was 76.8% for vaccines due by 9 months and 53.2% for vaccines due by 18 months. The reasons given for not being imunised were clinic-related factors (47%), lack of information (27%), lack of information (27%), caregiver being unable to attend the clinic (23%) and lack of motivation (14%). Of clinic factors cited, the two commonest factors were missed opportunities (34%) and being told by clinic staff to come back another time (20%). Factors enhancing coverage included possession of a Road-to-Health card, caregiver knowledge about vaccines and perceived attitude of clinic staff. Certain racial inequities in coverage were also apparent, particularly in the Boland-Overberg Region. [Conclusion] While the coverage indicated that a lot of good work has been done, the coverage was insufficient to prevent outbreaks of measles and other common childhood conditions including polio. The coverage was too low to consider not running periodic mass campaigns for measles and polio. The reasons given by caregivers for their children not being immunized and factors associated with increased coverage are valuable pointers as to where interventions should be focused.
Стилі APA, Harvard, Vancouver, ISO та ін.
37

Harrop, Jeremy Alexander. "The role of natural killer cells in respiratory syncytial virus infection of BALB/c mice." Thesis, University of Newcastle Upon Tyne, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287417.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
38

Tamizifar, Hassan. "Enhancement of subunit influenza vaccine with diptheria - tetanus - pertussis (DTP) vaccination." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388739.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
39

Berry, P. R. "Production of monoclonal antibodies to Bordetella pertussis as a means of identifying protective antigens." Thesis, University of Reading, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376819.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
40

Perrie, Yvonne. "Liposomes as a gene delivery system." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312844.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
41

Stagg, A. J. "Characterisation of the immune response of mice to Mycobacterium leprae." Thesis, University College London (University of London), 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380659.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
42

Lam, Shang Leen Clifford. "Plasma procurement and clinical evaluation of an intravenous immunoglobulin preparation." Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/19028.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
43

Genin, Christian. "Étude des facteurs favorisant les dépôts glomérulaires d'immunoglobulines chez la souris : effet de la charge de l'antigène : effet de l'immunisation orale dans la souche C3H/HeJ." Lyon 1, 1986. http://www.theses.fr/1986LYO1H060.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
44

Murphy, Catherine Estelle. "Conditions for sustainability in the Global Alliance for Vaccines and Immunisation." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417379.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
45

Ribeiro, Suzie Jesus. "A study of DNA/Dendron nanoparticles for genetic immunisation against anthrax." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439784.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
46

RUGO-COSTA, MARIE-AGNES. "Xeno-immunisation anti-thymoglobuline et anti-lymphoglubine chez les transplantes renaux." Nancy 1, 1993. http://www.theses.fr/1993NAN10207.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
47

Chigwenah, Tariro. "Explaining the socio-economic inequalities in child immunisation coverage in Zimbabwe." Master's thesis, University of Cape Town, 2020. http://hdl.handle.net/11427/32533.

Повний текст джерела
Анотація:
Socioeconomic inequalities in health have received significant attention globally because of the well-known association between wealth and health. A lot of studies show that poor people are more prone to sickness than their counterparts. Immunisation has been a key antidote to avert deaths for children under the age of 5. This study represents an initial attempt to assess specific variables that contribute to socioeconomic inequalities in immunisation coverage in Zimbabwe. Data were obtained from the 2015 Zimbabwe Demographic Health Survey, a nationally representative survey. Immunisation coverage was measured using four categories: full immunisation (a child who will have received 10 doses of vaccines), partial immunisation (a child who will have received at least one but not all vaccines), no immunisation (a child who will not have received any immunisation dose from birth) and immunisation intensity (a proportion of doses received to total doses that they should have received). Inequalities in immunisation coverage in Zimbabwe were assessed using concentration curves and indices. A positive (negative) concentration index indicates immunisation coverage concentrated among the rich (poor). The concentration index was decomposed to identify how different variables contribute to the socioeconomic inequality in immunisation coverage in Zimbabwe. Results indicate that immunisation intensity and full immunisation concentration indices were (0.0154) and (0.0250) respectively, indicating that children from lower socio-economic status are less likely to receive all doses of vaccines. No immunisation and partial immunisation concentration indices were (-0.0778) and (-0.0878) indicating that children from higher socioeconomic status are more likely to have their children immunised opposed to their poor counterparts. The main contributors to socioeconomic inequality in immunisation coverage are the mother's education, socioeconomic status and place of residence (rural/urban and province). While immunisation services are free of charge in the public health sector in Zimbabwe, coverage rates are higher among the wealthy, which shows that there may be barriers to utilising these services that may not be the direct cost of vaccination. There have to be measures by the government to reach people in areas that are not easily accessible. Also, more needs to be done to reduce socioeconomic inequalities in Zimbabwe.
Стилі APA, Harvard, Vancouver, ISO та ін.
48

DEVILLERS, HERVE. "L'exsanguino-transfusion in utero dans l'allo-immunisation foeto-maternelle anti-d." Amiens, 1992. http://www.theses.fr/1992AMIEM082.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
49

Joseph, Telphia-Leanne. "An investigation into how Aboriginal Medical Services contribute to childhood immunisation." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/12550.

Повний текст джерела
Анотація:
While there are diverse immunisation service providers, according to the Australian Childhood Immunisation Register (ACIR), less than 1% of all childhood vaccinations (equating to less than 10% of all Aboriginal children) are recorded as being delivered by an Aboriginal Medical Service (AMS). This is likely to be an under-estimate of the care provided. This study sought to determine to what extent AMS’s contribute to the immunisation of Aboriginal children in their local areas. Results The findings revealed that AMS’s in NSW are taking active steps to achieve an improvement in coverage and timeliness of immunisations that occur under NCIP for Aboriginal Children. In addition, the observations revealed various systematic processes in some AMS’s that directly contributed to up to 96% coverage of NCIP vaccines for regular clients. It also highlighted specific program implementation and community events that compliment immunisation through health promotion, reminders and follow up at different AMS’s. Conclusion This study showed that the ‘personality’ and commitment of individual AMS’s contributed significantly to the coverage rates of the children less than 5 years of age in the local areas of the AMS’s that participated in this study. Further investigation is needed to assess data collection at ACIR.
Стилі APA, Harvard, Vancouver, ISO та ін.
50

Capini, Christelle. "Immunisation active anti-cytokine dans la lutte contre les maladies auto-immunes." Paris 6, 2003. http://www.theses.fr/2003PA066395.

Повний текст джерела
Стилі APA, Harvard, Vancouver, ISO та ін.
Ми пропонуємо знижки на всі преміум-плани для авторів, чиї праці увійшли до тематичних добірок літератури. Зв'яжіться з нами, щоб отримати унікальний промокод!

До бібліографії