Дисертації з теми "Immune system genes"
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Wiltshire, Carolyn. "Molecular screens for the isolation of genes involved in Candida albicans morphogenesis." Thesis, University of Aberdeen, 1999. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU536131.
Повний текст джерелаWoolfson, Adrian. "Natural and artificial forms of human CD1 genes." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282946.
Повний текст джерелаSyed, Nelofer. "Development of systems to conditionally silence genes in the immune system of the mouse." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406646.
Повний текст джерелаAlvarez, Contreras Carlos Alberto. "HOST-MICROBIOME INTERACTIONS AND REGULATION OF THE IMMUNE SYSTEM." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1600446008947681.
Повний текст джерелаPereira, Lucas Campana. "Busca de genes associados à resposta ao teste de Montenegro para antígenos de Leishmania." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-27022013-155152/.
Повний текст джерелаThe present study aims, through genetic-epidemiological methods, to identify genes associated with response to Leishmania antigen. Using samples Montenegro skin test through the municipalities of Monte Negro (RO) and Assis Brazil (AC). In the first approach were tested with TaqManÒ and the second GWAS, and association analyzes were performed using SPSS and Plink. No associations were found with five SNPs (MyD88, IL12, IL10, IFNGR1, and NRAMP1). The analysis of genome scan data with filters, indicated a region on chromosome 10 with three nearby SNPs that are part of a regulatory region that later with the help of real time is not confirmed, although the test rs11251056 have borderline values, becoming an possible direction for future work and finally the last test was the meta-analysis by the method of Woolf, presented results indicating the association found in tests for chromosome 2 with ZNF638 related to cell differentiation and also on chromosome 10 that contains lincRNAs and gene NGR3, two runs with a significant p value, where we can infer that these two regions can actively participate in the differentiation of the response to Leishmania antigen.
Watherston, Oliver Gavin. "The effect of small DNA tumour virus oncoprotiens on the expression of genes involved in the immune system." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535132.
Повний текст джерелаLo, Amanda Susana. "Role of Genes in the Jak-Stat Pathway in the Innate Immune System and Immunosenescence in Drosophila melanogaster." Thesis, University of Maryland, Baltimore County, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10275514.
Повний текст джерелаFor many organisms, the immune system tends to deteriorate with age, leading to higher susceptibility to foreign pathogens. While several biological pathways are associated with immunity, the components of the Janus-kinase-Signal Transducers and Activators of Transcription (JAK-STAT) pathway on immunity at different age groups is unclear. This study explored the knock down effects of the Drosophila JAK-STAT pathway components and a candidate gene, robo3, in blood cells. Assessments of immune function were conducted through bacterial clearance assays and phagocytosis assay at one-week and five-weeks of age. This study suggests that some JAK-STAT pathway components important in other cell types seem to have less of a role in blood cells and immunity.
Baú, Carlos Eduardo Giuliani. "IDENTIFICAÇÃO DE GENES DIFERENCIALMENTE EXPRESSOS EM GLIOBLASTOMA E SUA RELAÇÃO NAS VIAS DO SISTEMA IMUNOLÓGICO Santa Maria, RS 2016." Centro Universitário Franciscano, 2016. http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/546.
Повний текст джерелаMade available in DSpace on 2018-08-17T11:25:27Z (GMT). No. of bitstreams: 2 Dissertacao_CarlosGiulianiBau.pdf: 1353900 bytes, checksum: 97f6ca9357595d662e670288c56e4552 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2016-03-30
Microarrays are instruments for measurement and analysis of several genes simultaneously, one of its uses is the verification of distinguishing gene expression in diseases. This work aims to verify the distinction between the expression of proteins in glioblastoma, using the data collected from the Gene Expression Omnibus database, because this cancer is characterized as of high incidence and it’s difficult to treat. After computational statistical analysis, it was found that the genes TNIP2, TOLLIP, IKBKB, PSMF1, RASGRF2, NEFL, DNM1, CDC42, YES1, C1S and PAK1, are differentially expressed in the pathways of the immune system, however, only the genes TNIP2, TOLLIP, IKBKB, are part of the NF-KB pathway, known to fight inflammation. The expectation of this work, and it´s future studies, hope to demonstrate different expressed genes in the immune system and thus help to better understand the development of the disease and its treatment, by nanoencapsulation of temozolimoda, a drug used along with radiotherapy.
Microarranjos são instrumentos para leituras e análise de vários genes simultaneamente, sendo uma de suas utilizações a verificação da distinção de expressão de genes em doenças. A partir disso, este trabalho busca verificar a distinção de expressão entre as proteínas de glioblastoma, por meio de dados recolhidos do banco de dados Gene Expression Omnibus, por caracterizar-se como um câncer de grande incidência e difícil tratamento. Na análise estatística computacional realizada, constatou-se que os genes TNIP2, TOLLIP, IKBKB, PSMF1, RASGRF2, NEFL, DNM1, CDC42, YES1, C1S e PAK1, encontram-se diferencialmente expressos nas vias do sistema imunológico, porém, somente os genes TNIP2, TOLLIP, IKBKB, fazem parte da via NF-KB, conhecida no combate à inflamação. Espera-se com esse trabalho, além de aprimorá-lo em estudos futuros, complementar os estudos nesta área, pois sua análise poderá demonstrar diferentes genes expressos nas vias do sistema imunológico, podendo, assim, auxiliar na melhor compreensão no desenvolvimento da doença, bem como, seu tratamento, por meio da nanoencapsulação do temozolimoda, medicamento utilizado juntamente com radioterapia.
Silva, Cláudia Regina dos Santos. "Análise da expressão de genes envolvidos na resposta inflamatória em crianças com síndrome de Down." Faculdade de Medicina de São José do Rio Preto, 2015. http://hdl.handle.net/tede/286.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
ABSTRACT Introduction: Down syndrome (DS) is a genetic disorder caused by the presence of an extra copy of human chromosome 21 (HSA21) with an incidence of one in 660 live births. Individuals with DS show alterations of the immune system resulting in increased frequency of infections and autoimmune diseases. Studies show that some genes involved in the immune system present altered expression in individuals with DS, however, the molecular mechanisms by which trisomy 21 leads to the immune system disorders in DS remain poorly investigated. Objective: This study aimed to investigate the expression pattern of a specific set of genes involved in the immune system and inflammation process in children with DS and children without the syndrome (control group), to identify differences that may be related to clinical manifestations of the syndrome. Casuistic and Methods: In this study were included six children with DS and six children without the syndrome. The quantification of the gene expression was performed using TaqMan ® Array Plate Human Inflammation Kit, which enables the investigation of 92 inflammation-related genes and four reference genes by real-time polymerase chain reaction (qPCR). Results: Of the 92 genes analyzed, 20 genes showed differential expression in children DS; 12 overexpressed (PLA2G2D, CACNA1D, ALOX12, VCAM1, ICAM1, PLCD1, ADRB1, HTR3A, PDE4C, CASP1, PLA2G5 e PLCB4) and 8 underexpressed (LTA4H, BDKRB1, ADRB2, CD40LG, ITGAM, TNFRSF1B, ITGB1 e TBXAS1). After statistical correction for false discovery rate, only the genes BDKRB1 and LTA4H showed differential expression, both underexpressed. Conclusion: DS children show differential expression of genes, not located on chromosome 21, compared to children without DS. The altered expression of these genes, considering their functions in the inflammatory response, suggests an important role in DS pathogenesis.
RESUMO Introdução: A síndrome de Down (SD) é um distúrbio genético causado pela presença de uma cópia extra do cromossomo humano 21 (HSA 21) com uma incidência de um a cada 660 nascidos vivos. Indivíduos com SD apresentam alterações no sistema imunológico que resultam no aumento da frequência de infecções e doenças autoimunes. Estudos mostram que alguns genes envolvidos no sistema imunológico apresentam expressão alterada em indivíduos com SD, entretanto, os mecanismos moleculares pelos quais a trissomia do 21 leva aos distúrbios do sistema imunológico em SD permanecem pouco investigados. Objetivo: O presente trabalho teve como objetivo investigar o padrão de expressão de um conjunto específico de genes envolvidos no sistema imunológico e no processo inflamatório em crianças com SD e crianças sem a síndrome (grupo controle), visando identificar diferenças que possam estar relacionadas com manifestações clínicas da síndrome. Casuística e Métodos: Foram incluídas no estudo seis crianças com SD e seis crianças sem a síndrome. A quantificação da expressão gênica foi realizada com o kit TaqMan® Human Plate Inflammation Array, que permite a investigação de 92 genes relacionados com a inflamação e quatro genes de referência pelo método de reação em cadeia da polimerase quantitativa em tempo real (PCRq). Resultados: Dos 92 genes analisados, 20 genes apresentaram expressão diferencial em crianças com SD; 12 com expressão aumentada (PLA2G2D, CACNA1D, ALOX12, VCAM1, ICAM1, PLCD1, ADRB1, HTR3A, PDE4C, CASP1, PLA2G5 e PLCB4) e oito com expressão reduzida (LTA4H, BDKRB1, ADRB2, CD40LG, ITGAM, TNFRSF1B, ITGB1 e TBXAS1). Após correção estatística para múltiplos testes apenas os genes BDKRB1 e LTA4H apresentaram expressão diferencial, ambos com expressão reduzida. Conclusão: Crianças com SD apresentam expressão diferencial de genes, não localizados no cromossomo 21, em relação a crianças sem a síndrome. A expressão alterada desses genes, considerando suas funções na resposta inflamatória, sugere um papel relevante na patogênese da SD.
Shater, A. F. "Investigation of DNA variation in genes of the immune system in wild populations of Apodemus sylvaticus in relation to infection by Toxoplasma gondii and helminth parasites." Thesis, University of Salford, 2017. http://usir.salford.ac.uk/44600/.
Повний текст джерелаBilal, R. "Dynamics of gene regulatory networks in the immune system." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1386220/.
Повний текст джерелаSeymour, Rosemarie. "Mutations in the Mouse Sharpin Gene Cause the Chronic Proliferative Dermatitis Phenotype." Fogler Library, University of Maine, 2008. http://www.library.umaine.edu/theses/pdf/SeymourR2008.pdf.
Повний текст джерелаRoberts, Amy Louise. "Genetic variation of innate immune receptor genes in Systemic Lupus Erythematosus." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/genetic-variation-of-innate-immune-receptor-genes-in-systemic-lupus-erythematosus(9f2194d8-f4d5-4fe8-abda-b6712e34404a).html.
Повний текст джерелаSotsios, Yannis. "Chemokines and T cells : activation requirements for RANTES secretion and CXCR4 signalling in mature T cells." Thesis, University of Bath, 2000. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323606.
Повний текст джерелаCooper, Laken N. "Effects of Sleep Fragmentation on the Immune System of Zebra Finches Using Cytokine Gene Expression." TopSCHOLAR®, 2016. http://digitalcommons.wku.edu/theses/1623.
Повний текст джерелаNeto, Guilherme Tude Coelho. "Peptídeo antimicrobiano LL-37 e seus efeitos em stemness de diferentes células tumorais." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5164/tde-06032017-104147/.
Повний текст джерелаAntimicrobial peptides play critical protective roles in a range of human diseases, including cancer. Multiple studies have demonstrated functions -- such as proliferation, angiogenesis, apoptosis and immunomodulation -- of these peptides in crucial cancer pathways. We investigated the role of the antimicrobial peptide LL-37 on stemness in breast cancer (SKBR3) and melanoma cells (A375). PCR array analysis of differential gene expression in SKBR3 and A375 cancer cell lines downregulated for LL-37 expression by siRNA revealed downregulation of genes related to stemness, including telomerase reverse transcriptase, forkhead box D3 and undifferentiated embryonic cell transcription factor 1, remarkably in breast cancer cells. Furthermore, SKBR3 cells knocked down for LL-37 expression showed a decreased production of oncospheres in comparison with negative controls, while A375 cells exhibited increased production. Taken collectively, our findings indicate a role for LL-37 in cancer cell stemness depending on the cell type
Bassano, Irene. "Regulation of gene expression in the immune system and in virally-transformed cells." Thesis, University of Leeds, 2014. http://etheses.whiterose.ac.uk/7724/.
Повний текст джерелаAsderakis, Argiris. "Influence of cytokine gene polymorphisms on kidney transplant outcome : the case of IFN-γ". Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493685.
Повний текст джерелаIngram, Richard J. M. "Duodenal ulcer promoting gene : effects on the pathophysiology of Helicobacter pylori infection and the host immune response." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/42105/.
Повний текст джерелаMonaco, G. "Computational approaches to study the immune system using gene expression and flow cytometry data." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3017054/.
Повний текст джерелаLorenzoni, Marco. "Pro-Tumorigenic role of ETS-related gene (ERG) in precursor prostate cancer lesions." Doctoral thesis, Università degli studi di Trento, 2019. http://hdl.handle.net/11572/242659.
Повний текст джерелаAmlinger, Lina. "The type I-E CRISPR-Cas system : Biology and applications of an adaptive immune system in bacteria." Doctoral thesis, Uppsala universitet, Mikrobiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-312234.
Повний текст джерелаXu, Yang. "A Systems Approach to Dissecting Immune Gene Regulatory Networks in the Modulation of Brain Function." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/924.
Повний текст джерелаXu, Yang. "A Systems Approach to Dissecting Immune Gene Regulatory Networks in the Modulation of Brain Function." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/924.
Повний текст джерелаMacedo, Claudia. "O papel modulador do gene Aire (autoimmune regulator) sobre redes de expressão gênica em células tímicas epiteliais medulares." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-13042009-144302/.
Повний текст джерелаThe expression of tissue restricted antigens (TRAs) in thymus by medullary thymic epithelial cells (mTECs) is essential for the central selftolerance of T cells. Due to heterogeneity of autoantigen representation this phenomenon has been termed promiscuous gene expression (PGE), in which the autoimmune regulator (Aire) gene plays a role as main positive transcriptional regulator on a large set of Aire-dependent TRAs. Aire protein is able in binding to specific DNA sequence motifs and plays a role as a direct regulator. Here we used the cDNA microarray method to access PGE in murine CD80+ mTECs cultured in vitro. Hierarchical clustering of the data allowed observation that TRA genes were differentially expressed. To further investigate the control of PGE, we hypothesize that TRA genes establish networks contributing it selves to modulate their transcriptional levels. Aire in this case plays a role as upstream positive modulator. To test this hypothesis, initially we silenced Aire by gene knockdown (RNA interference) in mTECs. Hierarchical clustering of cDNA microarray data showed a set of Airedependent TRAs genes, which were down regulated after Aire silencing. Gene networks reconstructed from these data allowed the identification of a gene node (Gucy2d) establishing positive regulation upon downstream genes in normal mTECs. Nevertheless, under silencing of Aire, Gucy2d has become a repressor. These finding evidentiate that, genes features in PGE are connected in network; a gene node may act as intermediate in their control and that Aire in PGE network plays a role as an upstream regulator.
Fernández, Bravo Ana. "Epidemiology and pathogenic characterization of species of the genus Aeromonas." Doctoral thesis, Universitat Rovira i Virgili, 2019. http://hdl.handle.net/10803/667146.
Повний текст джерелаEl género Aeromonas incluye más de 32 especies, algunas de las cuales están distribuidas en el medio ambiente y se consideran autóctonas de los sistemas acuáticos. El objetivo principal de esta tesis fue contribuir al mejor conocimiento de la epidemiología y la patogenicidad de este género. En este trabajo se ha investigado la presencia de Aeromonas en diferentes fuentes de agua demostrando que el método de floculación de leche desnatada utilizado para detección de virus parece ser un buen método para la detección de estas. Además, el análisis de A. salmonicida, una especie asociada clásicamente con enfermedades en peces utilizando un modelo de ratón, confirmó que esta especie puede infectar mamíferos con diferentes niveles de patogenicidad. Teniendo en cuenta el aumento de las infecciones por Aeromonas en los últimos años, se han llevado a cabo colaboraciones con hospitales. También se demostró que el uso de MALDI-TOF para la identificación de Aeromonas aisladas de peces era poco precisa debido a las carencias en la base de datos. El uso de genomas, su comparación y el desarrollo de nuevas herramientas bioinformáticas, demostró ser útil para entender la función de las especies. En esta tesis doctoral se llevó a cabo la caracterización de la metalochaperona HypA previamente descrita en otros patógenos, demostrando el rol en la tolerancia al ácido del estómago y en la defensa de Aeromonas contra macrófagos. Además, se ha demostrado el rol de la toxina ExoA y el sistema de secreción tipo VI (SST6) en las infecciones mixtas que progresan en una fascitis necrotizante, mediante el estudio de cepas aisladas de un paciente de Estados Unidos. Finalmente, un estudio de la defensa de monocitos humanos contra Aeromonas se llevó a cabo. Los resultados demostraron una respuesta immune especie-específica, siendo más fuerte en las especies más prevalentes en clínica.
The genus Aeromonas includes more than 32 species, some of which are distributed in the environment and are considered to be indigenous to aquatic systems. The main objective of this thesis was to contribute to a better knowledge of the epidemiology and pathogenicity of this genus. In this work we have investigated the presence of Aeromonas in different water sources demonstrating the method of skimmed milk flocculation used for virus detection, it seems to be a good method for the detection of these bacteria. In addition, the analysis of A. salmonicida, a species classically associated with fish diseases using an in vivo model, confirmed that this species can infect mammals with different levels of pathogenicity. Considering the increase of infections by Aeromonas in recent years, different collaborations with university hospitals have been carried out to investigated different cases . It was also shown that the use of MALDI-TOF for the identification of Aeromonas spp isolated from clinical cases and fish was not precise due to the deficiencies in the database. The use of genomes, their comparison and the development of new bioinformatic tools, proved to be useful to understand the potential function of A. lusitana and A. salmonicida in the environment. In this doctoral thesis the metallochaperone HypA previously described with role in tolerance to stomach acid in other pathogens was characterized and in the defense of Aeromonas against macrophages. In addition, the role of the ExoA toxin and the type VI secretion system (T6SS) in mixed infections that progress in a necrotizing fasciitis have been demonstrated, using several mutant strains. Finally, a study of the defense of human monocytes against Aeromonas was performed. The results showed a species-specific immune response, that was higher in the most prevalent clinical species.
Williman, Jonathan A., та n/a. "The use of the cytokines IFNγ, IL-12 and IL-23 to modulate immune responses raised by the gene gun method of DNA vaccination". University of Otago. Department of Microbiology & Immunology, 2007. http://adt.otago.ac.nz./public/adt-NZDU20070405.151123.
Повний текст джерелаBrown, David Spaulding. "CD4+ T Cell Responses: A Complex Network of Activating and Tolerizing Signals as Revealed by Gene Expression Analysis: A Dissertation." eScholarship@UMMS, 2005. https://escholarship.umassmed.edu/gsbs_diss/230.
Повний текст джерелаGallwitz, Maike. "Sculpted through Time : Evolution and Function of Serine Proteases from the Mast Cell Chymase Locus." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7379.
Повний текст джерелаJohansson, Martin. "Systemic lupus erythematosus and rheumatoid arthritis analyses of candidate genes involved in immune functions, for susceptibility and severity /." Doctoral thesis, Umeå : Umeå university, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-30388.
Повний текст джерелаMattana, Teresa Cristina Colvara. "Variantes do gene CD226 associadas com a susceptibilidade ao diabetes mellitus tipo 1 autoimune." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-26102012-103243/.
Повний текст джерелаRecently, Genome Wide Association (GWA) studies identified a new locus, 18q22, as a canditate to Type 1 A, or immune mediated diabetes (T1AD) susceptibility. This locus harbors the CD226 gene, responsible for encoding the leukocyte adhesion molecule (CD226) involved in cell adhesion, differentiation of naïve CD4+T cells, cytotoxicity induced by natural killer (NK) cells and cytokine production. Although just one single nucleotide polymorphism (SNP) rs763361 A/G had been related to T1AD, little is known about the involvement of new variants of CD226, implicated in other autoimmune disorders, in the pathogenesis of T1AD. In order to identify polymorphic variants related to T1AD susceptibility and their influences in phenotypic characteristics and other manifestations of autoimmunity, 532 type 1A diabetic patients and 594 health controls were enrolled in this study. Initially, in a subset of 106 diabetics and 102 controls, coding and flanking regions of CD226 gene obtained from genomic DNA extraction were amplified by polymerase chain reaction technique and subjected to direct sequencing. In a second step, the polymorphisms rs763361, rs727088 and rs1788101 were genotyped by TaqMan assay in the remaining patients and controls. Results: 12 variants in CD226 gene, seven of them with frequency above 5 % where identified. We did not found new variants. The variant rs727088 was not in Hardy Weinberg equilibrium in the control group. The genotypes AA (OR=1.45; p=0.005) and CC (OR=1.41; p=0.01) related to rs763361 and rs727088 variants respectively, were associated with risk of T1AD. Both predominated in female (p<0.01). Further, these variants were in linkage disequilibrium. The genotype haplotype ACAC formed by the risk variants was more frequent in patients with diabetes (30.5% x 25.6%; OR=1.42; p=0.014). The AA genotype of rs763361, the CC genotype and ACAC genotype haplotype were associated with lower levels of C-peptide in patients with no more than two years of disease course. The presence of pancreatic and extra-pancreatic autoantibodies was not associated with CD226 SNPs. Conclusion: The AA genotype of rs763361 variant of the gene CD226 predisposes to autoimmune diabetes in our population, as well as to lower levels of C-peptide, contributing to the aggressiveness of the disease. It predominated in female. Data of rs727088 variant should be analyzed with caution due to the lack of Hardy Weinberg equilibrium in the control group
Fornari, Thaís Arouca. "Análise da expressão gênica promíscua no timo de camundongos NOD (non obese diabetic) durante a emergência do Diabetes melitus tipo 1." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-13042009-150027/.
Повний текст джерелаImmunologic tolerance is an essential property of the immune system, which controls immune reactions directed against the body self components. The thymus is seen as the main organ involved with the tolerance induction to self antigens, which are expressed by the thymic cells (central tolerance), while the tolerance induction to the diverse other peripheral tissues and organs is attributed to extra thymic mechanisms (peripheral tolerance). Nevertheless, the evidence for the expression of peripheral tissue related antigens (TRAs) in the thymus by the medullary thymic epithelial cells (mTECs) of mice and humans, which have been termed to as promiscuous gene expression (PGE), has contributed to the concept of central tolerance to TRAs. The molecular control of such gene expression has been attributed to the Aire (autoimmune regulator) gene, which plays a role as a transcriptional regulator. In the present study, we searched to picture PGE in the thymus of NOD (non obese diabetic) mice by means of high throughput gene expression, analyzing the transcriptome by the cDNA microarray method. To analyzing data we used bioinformatics programs dedicated to microarrays and specialized data banks to characterize PGE and genetic susceptibility to type 1 diabetes mellitus (DM-1). Studying pre and autoimmune NOD mice, we evidentiate three sets of results. In the first set, it was observed the occurrence of PGE of parenchymal tissue/organs antigens (TRAs) in fresh thymuses and in thymuses cultured in vitro in adult thymus organ cultures (ATOC). The second set of results consisted in the analysis of the effect of in vitro (ATOC) Aire gene silencing on PGE. Finally, in the third data set, we demonstrated that certain promiscuously expressed genes are positioned in DM-1 genetic susceptibility chromosomal regions (idds). As three of such genes (IL4, Cd4 and Cdk4) are directly associated to the DM-1 pathogenesis in mice, it was possible to establishing a parallel between PGE in the thymus and genetic susceptibility to this autoimmune disease.
Zhang, Fengmin. "Resistance to Friend Murine Leukemia Virus Infection Conferred by the Fv-4 Gene is Recessive but Appears Dominant From the Effect of the Immune System." Kyoto University, 2001. http://hdl.handle.net/2433/150599.
Повний текст джерелаSchultis, Kim [Verfasser], and Bianca [Akademischer Betreuer] Schaub. "Potential biomarkers for the prediction of childhood wheeze : insights into new gene regulation mechanisms of the innate immune system at birth / Kim Schultis ; Betreuer: Bianca Schaub." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1218465875/34.
Повний текст джерелаMexal, Sharon. "Differential expression in the hippocampus of schizophrenic and control smokers : a high-throughput analysis of the effects of psychopathology, smoking, and postmortem brain parameters on gene expression /." Connect to full text via ProQuest. IP filtered, 2005.
Знайти повний текст джерелаPietrzak, Elżbieta. "Wpływ galaktooligosacharydów na modulację ekspresji genów związanych z układem immunologicznym ptaków i ryb." Rozprawa doktorska, Uniwersytet Technologiczno-Przyrodniczy w Bydgoszczy, 2020. http://dlibra.utp.edu.pl/Content/3212.
Повний текст джерелаNarayan, Kavitha. "The Function of Innate γδ T Cell Subsets is Molecularly Programmed in the Thymus in Three Stages: A Dissertation". eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/527.
Повний текст джерелаBitter, Sondhja. "Influence of specific farming activities of pregnant mothers on gene-expression of CD14 and toll-like receptors of the newborn : indicators for prenatal priming of the immune system /." Basel, 2007. http://www.public-health-edu.ch/new/Abstracts/BS_07.04.08.pdf.
Повний текст джерелаTrotta, Maria Beatriz Fortunato. "Mecanismos inflamatórios e imunológicos na síndrome de Down." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-04032010-175343/.
Повний текст джерелаIn recent years there has been an increase in life expectancy of individuals with Down´s syndrome (DS), with death causes differ from the general population. Some studies have shown that the immune response differs throughout life with changes related to aging. The RCAN1 gene (regulator of calcineurin type 1), located in the q22.12 region of chromosome 21 is described as responsible for the phenotype of DS. The gene RCAN1 inhibits the calcineurin activity, responsible for the dephosphorylation of the nuclear factor of activated T cells (NFAT), an essential step for the activation of the genes responsible for cytokines expression. The consequence is a possible reduction of the effector immune response. In adults with DS, the humoral and cellular immune responses have not been throughly investigated. Although the overexpression of the RCAN1 gene has already been described in many tissues, its expression in mononuclear cells of peripheral blood (PBMC) of adults with DS has not been evaluated. The objectives of this study were to evaluate aspects of humoral and cellular immune response, evaluate the quantitative expression of the RCAN1 gene and correlate the findings with the production of cytokines. The study group consisted of adults with Down´s syndrome (DS) with free trisomy karyotype (n = 24), a control group (CTR) composed of the mentally disabled of other etiologies (n = 21) and a group of healthy subjects (n = 8), as parameters for some experiments. The SD and CTR groups are followed in Associação de Pais e Amigos dos Excepcionais (APAE-SP). It was evaluated Hemogram and serology for detection of hepatitis B, cytomegalovirus, infectious mononucleosis, toxoplasmosis, rubella, measles, cRP, complement fraction C3, C4, antistreptolysin O and IgG, IgM and IgA immunoglobulin isotypes. The mononuclear cells were obtained by Ficoll-Hypaque gradient and the cells were cultured without stimuli, analyzed for the quantitative gene expression of RCAN1 and evaluated for immunophenotyping by flow cytometry. The culture supernatants were collected for measurement of cytokines IL-2, IL-4, IL-5, IL- 10, TNF and IFN.The results of this study showed that the frequency of positive tests for various infectious agents and other immunological parameters were comparable in both groups (DS and CTR). Immunophenotyping of individuals with DS showed an increase in NK cells, CD8 + lymphocytes, changes in CD4: CD8 ratio (1:1) and decreased B lymphocytes (CD19 +) when compared to the control group (p <0.05). The DS group had a spontaneous production of IFN, TNF and IL-10 higher than the CTR group (p<0.05). However, there was not any difference in RCAN1 gene expression (mRNA) between the two groups of the mentally disabled. The humoral and cellular immune profile in adults with Down´s syndrome from APAE-SP showed that there was no difference in the humoral aspects assessed in both groups (SD and CTR). For the cellular aspects, the immunophenotyping suggests a possible sign of premature aging of the immune system and the cytokine production show a proinflammatory profile. Nevertheless, this cytokines profile is not associated with level of expression of the RCAN1 gene.
Richards, Kathryn H. "Mutations in the vpu and env Genes of HIV-1 Can Adversely Impact Infectivity: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/378.
Повний текст джерелаChiu, Ya-Lin. "HIV-1 Gene Expression: Transcriptional Regulation and RNA Interference Studies: a Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/118.
Повний текст джерелаMelichar, Heather J. "SOX13, A γδ T Cell-Specific Gene, Is a WNT-Signaling Antagonist Regulating T Cell Development: A Dissertation". eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/251.
Повний текст джерелаRobertson, Chadia L. "Analysis of the Role of Astrocyte Elevated Gene-1 in Normal Liver Physiology and in the Onset and Progression of Hepatocellular Carcinoma." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3573.
Повний текст джерелаWarke, Rajas V. "Molecular Dissection of the Cellular Reponse to Dengue Virus Infection." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/366.
Повний текст джерелаQuillet, Anne. "Role des antigenes hla classe i dans la susceptibilite a la cytotoxine naturelle nk/lak." Paris 7, 1988. http://www.theses.fr/1988PA077142.
Повний текст джерелаBukhari, Zahida. "Controle genetique de la production d'interleukine-2 chez la souris." Paris 7, 1987. http://www.theses.fr/1987PA077022.
Повний текст джерелаMalhotra, Nidhi. "Distinct Gene Circuits Control the Differentiation of Innate Versus Adaptive IL-17 Producing T Cells: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/579.
Повний текст джерелаEqueter, Carole. "Analyse des profils d'expression génique des lymphocytes T CD4+ chez les patientes atteintes d'un cancer du sein." Doctoral thesis, Universite Libre de Bruxelles, 2009. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210249.
Повний текст джерелаSur base de l’établissement des profils d’expression génique des lymphocytes T infiltrant les tumeurs, nous avons dérivé la « tumor-infiltrating CD4+ signature » (TICD4S) composée de 61 gènes immuns et qui reflète l’état d’activation immunitaire. Cette signature présente une valeur prédictive chez les patientes porteuses de tumeurs ERBB2-positives et ER-négative/PR-négative/ERBB2-négative: une plus forte expression de ces gènes est associée à une meilleure survie.
Nous avons également étudié conjointement les profils géniques établis au départ des lymphocytes T CD4+ de la tumeur, du ganglion axillaire et du sang de dix patientes. Nous avons constaté que ces profils d’expression génique des TIL CD4+ diffèrent selon le statut ER de la tumeur qu’ils infiltrent. Les lymphocytes T ganglionnaires CD4+ subissent également les effets de la masse tumorale et, tout comme les TIL, sont moins activés chez les patientes porteuses de tumeurs ER-négatives. Par contre, les lymphocytes T sanguins semblent subir dans une moindre mesure les effets de la tumeur et peu de différences ont été notées par rapport à leurs homologues isolés chez des donneuses saines.\
Doctorat en Sciences
info:eu-repo/semantics/nonPublished
Ghosh, Sreya. "Different Journeys, Same Destination: Exploring the Role of a PYHIN Protein and Involvement of Caspase-8 in the Regulation and Activation of Inflammasomes." eScholarship@UMMS, 2009. http://escholarship.umassmed.edu/gsbs_diss/928.
Повний текст джерелаGhosh, Sreya. "Different Journeys, Same Destination: Exploring the Role of a PYHIN Protein and Involvement of Caspase-8 in the Regulation and Activation of Inflammasomes." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/928.
Повний текст джерела