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Статті в журналах з теми "Imagerie en biologie – Expérimentation animale"
VEISSIER, I. "Expérimentation animale : biologie, éthique, réglementation." INRAE Productions Animales 12, no. 5 (July 1, 1999): 365–75. http://dx.doi.org/10.20870/productions-animales.1999.12.5.3897.
Повний текст джерелаДисертації з теми "Imagerie en biologie – Expérimentation animale"
Rucher, Guillaume. "Imagerie moléculaire des lésions d'athérosclérose vasculaires et valvulaires chez la souris." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMC401/document.
Повний текст джерелаAtherosclerosis lesions are a leading cause of cardiovascular events. Atherosclerosis is a chronic inflammatory disease including complex molecular and cellular mechanisms. Mineralization process within the atherosclerosis lesions is a key feature of the disease development. Using a mouse model of accelerated atherosclerosis and imaging optimisation study, we showed the feasability of sodium fluoride positron emission tomography combined to magnetic resonance imaging to assess molecular activity in a mouse model of accelerated atherosclerosis. We showed that uremic animals had an early and sustained mineralization activity associated to an advanced inflammatory state. Furthermore, we developped a new mouse model of calcified aortic stenosis using targeted radiation exposure
Guillemant, Marie. "Development of a three-photon microscope for awake and behaving non-human primates." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASL025.
Повний текст джерелаMulti-photon microscopy has become a standard technique to study the structural and functional activity in mice but it faces obstacles to be applied in larger animals. It would be particularly advantageous to be able to apply it to macaque monkeys, as they are the animal model of choice to understand the neural mechanisms of high-level cognitive functions such as selective attention, working memory and consciousness. One of the main limiting factors for imaging in larger animals is the dura mater. This tough and opaque layer of tissue protects the brain but is so thick in larger animals that it obstructs imaging. It is therefore commonly removed but this leads to a highly invasive and unstable preparation. The main aim of the current work is to investigate the possibility to record functional activity from the cortex of the rhesus macaque monkey through the natural dura.A multi-photon microscopy setup has been designed with a two-photon and a three-photon microscopy optical paths to record from awake macaque monkeys. The repetition rate of the laser is 2MHz which allows a maximum imaging depth inside the cortex of 520µm at 960nm and 715µm at 1300nm with an additional 120µm-thick layer of dura mater at the surface. Resonance-galvo scanning is used to allow a maximal frame rate of 15.6Hz at a field of view of 620x630µm². In addition to the setup, surgical implants have been developed for long-term and awake imaging.Using an ex vivo study of dura mater from a macaque monkey, the induced optical aberrations are studied by measuring the decrease in spatial resolution of the setup for a varying thickness of dura mater. This reveals that it has no significant impact on the spatial resolution for a thickness up to 150µm at 1300nm. The effective attenuation length of the dura mater is estimated to be 56.5±10.1µm at 960nm and 80.7±5.3µm at 1300nm. These measurements are used to model the maximum imaging depth that can be reached according to the repetition rate of the laser and the thickness of the dura.This model is adjusted and validated using in vivo data from two non-human primates. The effective attenuation length of the natural dura mater and of a regrowth of tissue following a durectomy (called a 'neomembrane') are investigated. Functional recordings have been performed in mice and preprocessed using Suite2P. Viral injection parameters have been tested in three macaque monkeys and we have so far recorded the in vivo structural and functional activity of neurons in one. Finally, the comparison between the use of two- and three-photon microscopy to study non-human primates is discussed. In conclusion, we have set up and optimized a multi-photon microscope for long-term awake imaging of the cortex of non-human primates and shown that it was possible to record down to over 700µm into the cortex (which corresponds to the layers L2/L3) while imaging through the natural dura mater or a neomembrane
Monteil, Jacques. "Imagerie au 18-FDG avec un tomographe d’émission de positons par détection de coïncidences (TEDC) : optimisation pour l’oncologie expérimentale animale." Limoges, 2004. http://www.unilim.fr/theses-doctorat/2004LIMO310D/html/index-frames.html.
Повний текст джерелаTropres, Irène. "Imagerie RMN de la microvascularisation cérébrale chez le rat : applications." Université Joseph Fourier (Grenoble), 1999. http://www.theses.fr/1999GRE19012.
Повний текст джерелаBreton, Élodie. "Applications précliniques de l'IRM à bas champ et sa place dans un contexte multimodal microTEMP et microTDM." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. https://publication-theses.unistra.fr/public/theses_doctorat/2007/BRETON_Elodie_2007.pdf.
Повний текст джерелаIn vivo preclinical imaging in small animals offers a unique insight in physiopathological processes. This PhD thesis is a study of the role that 0. 1T low field MRI could play in preclinical imaging considering its economical and technical characteristics. The specificities of preclinical imaging are first presented, then the technical adaptations developed for in vivo small animal imaging using 0. 1T MRI are detailed. These technical choices allow to obtain quantitative results using 0. 1T MRI in various in vivo imaging studies: anatomical (longitudinal follow-up of tumor growth), functional (triggered cardiac dynamic) and motion-sensitizing gradients (MRE). In a multimodal context, the complementarity of imaging techniques is shown through the simple and original conception of a dual SPECT/low field MRI modality, and the use of microCT in some specific soft tissues studies
Vazeille, Emilie. "Etude de la protéolyse protéasome-dépendante et de l'apoptose mitochondriale pendant l'atrophie et la récupération musculaire : rôle du curcumin." Clermont-Ferrand 1, 2009. http://www.theses.fr/2009CLF1MM02.
Повний текст джерелаUncontrolled and sustained muscle wasting observed in various catabolic situations (e. G. Aging, cancers, AIDS) may reduce the response to therapies and the efficiency of immune system, thus increasing morbidity and mortality. The subsequent weakness impairs human movement and ultimately can lead bed-rest, which is a worsening factor of muscle atrophy. Proteolytic and apoptotic pathways play a crucial role in the establishment of muscle atrophy. However, their respective role during recovery periods is not clearly defined. The purpose of my Ph. D. Thesis was to better characterize these mechanisms during muscle loss and the recovery following immobilization. Adult rats were subjected to unilateral hindlimb casting for 8 days and allowed to recover up to 40 days. The controlateral leg served as control in all experiments. We showed that the mitochondria-associated apoptotic pathway was up-regulated concomitantly to the ubiquitin(ub)-proteasome-dependent system during immobilization induced-muscle atrophy. We also demonstrate that these pathways are sequentially normalized during skeletal muscle recovery. Indeed, ub-proteasome-dependent proteolysis is normalized when muscle atrophy stabilized whereas the mitochondria-associated apoptotic pathway is later sequentially down-regulated and normalized when muscle mass increased. Finally, the daily administration of curcumin, which exhibit anti-oxydant and anti-inflammatory properties, speeded up muscle mass recovery by furthering the normalization of these two processes. In conclusion, my Ph. D. Thesis work demonstrated the crucial role of the mitochondria-associated apoptotic pathway during the casting induced-muscle atrophy. It further demonstrated that the ub-proteasome-dependent proteolytic and the mitochondria-associated apoptotic pathways are regulated according to different kinetics during muscle recovery. Finally, the study of the beneficial effects of curcumin indicated that nutritional strategies adapted to different stages of muscle recovery are conceivable to improve muscle mass accretion
Le, Bars Emmanuelle. "Application des techniques de spectroscopie et d'imagerie par résonance magnétique in "vivo" : étude des effets métaboliques cérébraux induits au cours d'une hypoxémie modérée et d'une ischémie focale chez le rat." Université Joseph Fourier (Grenoble), 1995. http://www.theses.fr/1995GRE19002.
Повний текст джерелаJoubert, Michaël. "Diabète et remodelage cardiaque : approches physiopathologiques et mécanistiques." Caen, 2016. http://www.theses.fr/2016CAEN3164.
Повний текст джерелаType 2 diabetes is growing epidemic worldwide and this metabolic disease is associated with increased cardiovascular morbidity and mortality. Long term hyperglycemia is involved in the development of atherosclerosis, especially in coronary arteries, but diabetes also causes direct myocardial abnormalities (diabetic cardiomyopathy). The mechanisms involved in the deleterious effects of diabetes on the heart are not yet fully explained. Using a rodent models with streptozotocin-induced diabetes, we explored the impact of diabetes, especially glycemic variability, on ischemia-reperfusion injury and the early impact of diabetes on the occurrence of diabetic cardiomyopathy. In addition, using a mouse model of lipo-atrophic diabetes, we also studied the mechanisms involved in diabetic cardiomyopathy and in particular the consequences of glucotoxicity. Parallel to this work, a methodological study evaluated the reproducibility of cardiac MRI in rodents, the main exploration tool for our work
Guignard, Léo. "Analyse quantitative de la morphogenèse animale : de l'imagerie laser haut-débit à l'embryon virtuel chez les ascidies." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTS048/document.
Повний текст джерелаAscidian embryos develop with stereotyped and evolutionarily conserved invariant cell lineages to produce in a few hours or days tadpole larvae with a small number of cells. They thus provide an attractive framework to describe with cellular resolution the developmental program of a whole organism. During my PhD, I developed a quantitative approach to describe the evolution of embryonic morphologies during the development of the ascidian Phallusia mammillata. I then used this approach to systematically characterize in detail the logic of cell fate induction events. To quantitatively characterize cell behaviors during embryogenesis, we used multi-angle light-sheet microscopy to image with high spatio-temporal resolution entire live embryos with fluorescently labeled plasma membranes. To extract biological information from this imaging dataset, I then developed a conceptually novel automated method for 4D cell segmentation, ASTEC. Applied to a Phallusia mammillata embryo imaged for 6 hours between the 64-cell and the initial tailbud stages, this method allows the accurate tracking and shape analysis of 1030 cells across 640 cell divisions. The resulting 4D digital embryo can be formalized as a dynamic graph, in which cells are represented by nodes, linked within a time point by edges that represent their spatial neighborhood, and between time points by temporal edges describing cell lineages.Based on this quantitative digital representation, we systematically identified cell fate specification events up to the late gastrula stage. Computational simulations revealed that remarkably simple rules integrating measured cell-cell contact areas with boolean spatio-temporal expression data for extracellular signalling molecules are sufficient to explain most early cell inductions. This work suggests that in embryos establishing precise stereotyped contacts between neighboring cells, the genomic constraints for precise gene expression levels are relaxed, thereby allowing rapid genome evolution
Lemasson, Benjamin. "Evaluation de l'IRM multiparamétrique comme indicateur de l'effet de thérapies anti-angiogéniques sur des modèles de gliomes implantés chez le rat." Phd thesis, Université de Grenoble, 2010. http://tel.archives-ouvertes.fr/tel-00908915.
Повний текст джерелаКниги з теми "Imagerie en biologie – Expérimentation animale"
(Roland), Frey R., and SpringerLink (Online service), eds. Anatomical Imaging: Towards a New Morphology. Tokyo: Springer Japan, 2008.
Знайти повний текст джерелаMolecular zoology: Advances, strategies, and protocols. New York: Wiley-Liss, 1996.
Знайти повний текст джерела(Editor), Joan D. Ferraris, and Stephen R. Palumbi (Editor), eds. Molecular Zoology: Advances, Strategies and Protocols. Wiley-Liss, 1996.
Знайти повний текст джерелаAmerican Society of Zoologists (Corporate Author), Joan D. Ferraris (Editor), and Stephen R. Palumbi (Editor), eds. Molecular Zoology: Advances, Strategies and Protocols. Wiley-Liss, 1996.
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