Дисертації з теми "IHg"
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Spink, Charlotte Fiona. "Genotyping and haplotyping using induced heteroduplex generators (IHG) : design aspects, automation and application to cytokine profiling in B cell lymphoproliferative diseases." Thesis, University of the West of England, Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418226.
Повний текст джерелаMinet, Antoine. "Bioaccumulation and effects of mercury in cuttlefish in the context of ocean acidification." Electronic Thesis or Diss., La Rochelle, 2022. http://www.theses.fr/2022LAROS039.
Повний текст джерелаThe common cuttlefish, Sepia officinalis, is a coastal cephalopod known for its eco physiological performance supported by a wide repertoire of behaviors that allows it, despite its short life cycle, to play a central role in food webs. However, it is also known to efficiently accumulate metallic elements such as mercury (Hg), a neurotoxic contaminant in its organic form (methylmercury; MeHg). Moreover, in the context of global changes, ocean acidification (OA) induced by the increase of CO2 emissions, can impact metabolism, development and the central nervous system, especially in young life stages. The present work therefore aims to study the effects of OA on Hg bioaccumulation and the effects of these two neurotoxicants (Hg and CO2) on behavior and cognitive performance in juvenile cuttlefish. In the first place, in-situ measurements showed that Hg accumulated in the brain of cephalopods in methylated form (MeHg). Moreover, experimental approaches using isotopic tracers (stable and radioactive) of Hg have shown that the accumulation of total Hg comes mainly from the assimilation of MeHg present in preys, compared to the accumulation of inorganic mercury (iHg) dissolved in seawater. This MeHg is then very strongly retained despite evidence of Hg demethylation processes in the digestive gland. Surprisingly, OA has no effect on the bioaccumulation efficiencies and metabolism of Hg. In terms of effect, behavioral assays showed that Hg and CO2, alone or in combination, did not impact visual acuity and predation performance in juveniles. However, both induced an increase in locomotor activity, compromised defensive behavior through, in particular, an alteration of disruptive coloration and a non-alignment of lateralization. Among the neural processes likely to be impacted by Hg and CO2, the GABAergic system was analyzed in the optic lobes but showed no obvious link with behavioral responses suggesting more complex effect processes. All of this work therefore questions the effects of future ocean conditions on juvenile’s cuttlefish, and more broadly the impacts on cephalopod populations
Bruhn, Elisa [Verfasser]. "Virtual Internationalization in Higher Education / Elisa Bruhn." Bielefeld : wbv Media, 2020. http://wbv.de/ihs.
Повний текст джерелаKauther, Ralf. "Hegels Dialektik : ihr Anfang, ihre Methode, ihr Ziel /." Köln : R. Kauther, 1998. http://catalogue.bnf.fr/ark:/12148/cb39174227s.
Повний текст джерелаKrüger, Hartmut. "Frauen im Pietismus : ihr Dienst, ihre Verantwortung, ihr Einfluss." Marburg an der Lahn Francke, 2005. http://deposit.ddb.de/cgi-bin/dokserv?id=2668119&prov=M&dokv̲ar=1&doke̲xt=htm.
Повний текст джерелаDaly, J. N. "IgH allelic exclusion at the level of IgH transcription." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598257.
Повний текст джерелаSartori, Viviane. "InHab-Read - IHR." reponame:Repositório Institucional da UFSC, 2017. https://repositorio.ufsc.br/xmlui/handle/123456789/180897.
Повний текст джерелаMade available in DSpace on 2017-11-14T03:21:56Z (GMT). No. of bitstreams: 1 348490.pdf: 9532825 bytes, checksum: bb189e301b30950fbc2c9049745f5d62 (MD5) Previous issue date: 2017
Os habitats de inovação são empreendimentos organizados sistematicamente para promover a inovação, propiciando a interação e a integração de diferentes atores. São fenômenos contemporâneos de grande relevância para o desenvolvimento de uma região ou de um país, pois operam com ativos de conhecimento. A implantação de um habitat de inovação implica, diretamente, no desenvolvimento socioeconômico e cultural da comunidade de seu entorno. Estes oferecem condições diferenciadas para desenvolver produtos e processos inovadores, com o propósito de fomentar as dinâmicas econômicas e sociais, locais e regionais, uma vez que tem a capacidade de reunir pessoas, tecnologias, recursos financeiros e conhecimento. A problemática levantada para esta pesquisa trata de como analisar as comunidades do entorno dos habitats de inovação em relação às suas necessidades, potencialidades e expectativas. O lastro teórico para esta tese está construído na intersecção entre os conceitos de habitats de inovação, parques tecnológicos, inovação, inovação social, tríplice e quádrupla hélice. O objetivo é elaborar uma metodologia para leitura e análise identificando, necessidades, potencialidades e expectativas das comunidades do entorno dos habitats de inovação. Esta pesquisa caracteriza-se como exploratória descritiva. Desenvolve-se a partir de uma revisão sistemática para levantar os conceitos básicos e um benchmarking para identificar práticas de leitura de entorno. Com estes elementos propõe-se uma metodologia de leitura de entorno desenvolvida em três fases: elaboração, prototipagem e aplicação. A elaboração constituiu-se em um instrumento online, que foi prototipada no entorno do Orion Parque, na cidade de Lages. A aplicação da metodologia para sua conformação foi feita no entorno do Sapiens Parque, em Florianópolis. Os atores envolvidos nesse processo foram gestores de 8 parques tecnológicos visitados, 10 gestores de organizações internas do Sapiens Parque, 201 gestores de organizações externas e 622 famílias situadas no entorno do Sapiens Parque. O resultado alcançado com este estudo foi a conformação de uma proposta metodológica adaptável para diferentes tipos de habitats de inovação, que possibilita realizar a leitura e a análisedo entorno desses empreendimentos, gerando informações que caracterizam o perfil da população local em relação às suas necessidades, potencialidades e expectativas. Com a aplicação da InHab-Read ? IHR ? Metodologia de leitura de entorno para habitats de inovação é possível orientar políticas e ações conjuntas entre a população do entorno e as organizações internas dos habitats, potencializando a interação entre todos os atores, e ampliando as dimensões dos processos de inovação tecnológica e econômica para a inovação social.
Abstract : Innovation habitats are systematically organized enterprises to promote innovation and provide the interaction and integration of different actors. They are contemporary phenomena of high relevance for the development of a region or a country because they operate with knowledge assets. The implementation of an innovation habitat directly implies the socioeconomic and cultural development of the surrounding community. These provide differentiated conditions for developing innovative processes and products to foster economic, social, local and regional dynamics as it can bring together people, technologies, financial resources, and knowledge. The issue regarding this research analyzes the communities surrounding the innovation habitats about their needs, potentialities, and expectations. The theoretical background for this thesis is built on the intersection between concepts of innovation habitats, technology parks, changes, social innovation, triple and quadruple propeller. The aim is to develop a methodology for reading and analysis, identifying needs, potentialities, and expectations of communities surrounding the innovation habitats. The study is characterized as descriptive and exploratory. It develops from a systematic review to obtain basic concepts and a benchmarking to identify surrounding reading practices. With such elements, it is proposed a methodology of environment interpretation developed in three phases: elaboration, prototyping, and application. The elaboration was constituted by an online instrument that was prototyped in the Orion Park?s surrounding, in the city of Lages. The methodology application for its configuration was developed in the Sapiens Park?s surrounding, in Florianópolis. The actors involved in the process were eight managers of the technological parks visited, ten managers of internal organizations of the Sapiens Parque, 201 managers of external companies and 622 families located around the Sapiens Parque. The result obtained with the study relates to an adaptive methodological proposal for different types of innovation habitats, which makes it possible to read and analyze the enterprises? surroundings, generating information that characterizes thelocal population profile regarding their needs, potentialities, and expectations. With the application of InHab-Read - IHR - Environment Reading Methodology for innovation habitats, it is possible to propose common policies and actions between the surrounding population and habits internal organizations, enhancing the interaction among all the actors, and broadening dimensions of technological and economic innovation processes for social change.
Säll, El Kebich Amina. "Adverbial ing-clauses and non-ing initial adverbials in medical translation." Thesis, Linnéuniversitetet, Institutionen för språk (SPR), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-97954.
Повний текст джерелаHoechtl, Nina. "If only for the length of a lucha : queer/ing, mask/ing, gender/ing and gesture in lucha libre." Thesis, Goldsmiths College (University of London), 2012. http://research.gold.ac.uk/8056/.
Повний текст джерелаRechenberg, Ingo. "Evolutionsstrategie '94 /." Stuttgart : Frommann-Holzboog, 1994. http://www3.ub.tu-berlin.de/ihv/000219248.pdf.
Повний текст джерелаSteinbach, Jörg. "Chemische Sicherheitstechnik /." Weinheim ; New York ; Basel ; Cambridge ; Tokyo : VCH, 1995. http://www3.ub.tu-berlin.de/ihv/000261483.pdf.
Повний текст джерелаFlecke, Ursula. "Zur Genese der Nachmoderne im Städtebau : Entwürfe 1960 - 1975 in Westdeutschland /." Berlin : Techn. Univ., Univ.-Bibliothek, Abt. Publ, 1999. http://www3.ub.tu-berlin.de/ihv/000568903.pdf.
Повний текст джерелаDehrendorf, Martin Heiss Michael. "Geo-Informationssysteme in der kommunalen Planungspraxis /." Norden ; Halmstad : Points-Verl, 2004. http://www3.ub.tu-berlin.de/ihv/000945955.pdf.
Повний текст джерелаWindeler, Arnold. "Unternehmungsnetzwerke : Konstitution und Strukturation /." Wiesbaden : Westdt. Verl, 2002. http://www3.ub.tu-berlin.de/ihv/001719509.pdf.
Повний текст джерелаNaredi-Rainer, Paul von. "Architektur und Harmonie : Zahl, Mass und Proportion in der abendländischen Baukunst /." Köln : DuMont, 2001. http://www3.ub.tu-berlin.de/ihv/000870583.pdf.
Повний текст джерелаQuijoux, Maxime Zagefka Polymnia Cosío-Zavala María-Eugenia. "Destins féminins, genre et autogestion dans une usine récupérée d'Argentine." [S. l.] : [s. n.], 2005. http://www.credal.univ-paris3.fr/IMG/pdf/MemoireDEAmaximeQuijoux.pdf.
Повний текст джерелаMazars, Nadège Gros Christian. "Mouvement indigène en Equateur." [S. l.] : [s. n.], 2005. http://www.iheal.univ-paris3.fr/IMG/pdf/DEA_v1_N_Mazars.pdf.
Повний текст джерелаKeller, Andreas. "Michael Kongehl (1646-1710) : Durchwandert ihn/gewiss ! Ihr werdet anders werden... : transitorische Textkonstitution und persuasive Adressatenlenkung auf der Basis rhetorischer Geneseprinzipien im Gesamtwerk des Pegnitzschäfers in Preussen /." Berlin : Weidler, 2004. http://catalogue.bnf.fr/ark:/12148/cb414689150.
Повний текст джерелаFung, Tak-kit. "Teaching the -ing forms." Click to view the E-thesis via HKUTO, 1986. http://sunzi.lib.hku.hk/HKUTO/record/B38626408.
Повний текст джерелаFung, Tak-kit, and 封德傑. "Teaching the -ing forms." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1986. http://hub.hku.hk/bib/B38626408.
Повний текст джерелаBodman, Katherine Birgitta. "IgG glycoforms in arthritis." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283129.
Повний текст джерелаZhang, Gaiping. "Bovine IgG Fc receptors." Thesis, University of Hertfordshire, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387187.
Повний текст джерелаZiegler, Jochen. "refin [d]ing process." Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/35586.
Повний текст джерелаMaster of Architecture
Drozd, Natalia. "Tailbone-ing movement practice." Thesis, Stockholms konstnärliga högskola, Institutionen för dans, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uniarts:diva-916.
Повний текст джерелаThis master work includes both a performing and a written part.
Sterk, Sabine. "Wunderheilmittel - und ihr Kommunikationsverhalten." [S.l. : s.n.], 2005. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11612072.
Повний текст джерелаNeumann-Hartmann, Arlette. "Epinikien und ihr Aufführungsrahmen." Hildesheim Weidmann, 2007. http://d-nb.info/99416906X/04.
Повний текст джерелаPourabadeh, J. "Analysis of IDG discontinuities." Thesis, University of Bath, 1998. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266472.
Повний текст джерелаMartin, Susanne. "Dancing age(ing) : rethinking age(ing) in and through improvisation practice and performance." Thesis, Middlesex University, 2016. http://eprints.mdx.ac.uk/18984/.
Повний текст джерелаRedpath, Stella. "Effector functions of human IgG." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363193.
Повний текст джерелаHarbek, Josefine. "Die Liebe und ihr Feind." Alexander Fuchs, 2012. https://slub.qucosa.de/id/qucosa%3A16294.
Повний текст джерелаMarvanová, Zuzana. "Analýza společenské odpovědnosti firmy ING." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-74057.
Повний текст джерелаHeidenhain, Brigitte. "Juden in Wriezen : ihr Leben in der Stadt von 1677 bis 1940 und ihr Friedhof." Universität Potsdam, 2007. http://opus.kobv.de/ubp/volltexte/2007/1519/.
Повний текст джерелаThe history of jews in Wriezen begins in 1677, shortly after Kurfürst Friedrich Wilhelm allowed jews to settle in Brandenburg again through his edict of 1671. However, during the whole of the 18th century Prussian policy toward jews was extremely restrictive . The results of this policy are clearly visible in the life of the jews of Wriezen: they always remained a small congregation since this was the will of the king for small towns. Life was dominated by the struggle for the right of residence. Status as "Schutzjude" (i.e. "Protected Jew") was restricted to few individuals, leading to the separation of families as younger siblings were forced to leave. State regulated economic policy strongly restricted the freedom of trade, the main source of income for the jews, leading to the impoverishment of most jewish families in Wriezen. In the 18th century, there was no organized congregational activity. This only developed in the course of the 19th century. The jews of Wriezen built their first synagogue in 1820, replacing it with a new and larger one in 1886. The emancipation edict of 1812 improved the general situation of individuals and the new freedom of movement led to an influx of jews to Wriezen. But full legal equality with other citizens was not achieved until the German Empire was founded in 1871. In the first half of the 19th century, the economic situation of the jews of Wriezen was still quite modest, only improving toward the end of the century. There were numerous fluctuations in the membership of the jewish community in the last decades of the 19th and the beginning of the 20th century. But the number of jewish inhabitants of Wriezen remained relatively constant at 100 -120 individuals. There is hardly any written information on the sudden and complete end of jewish life in Wriezen after 1938. At least 59 jewish citizens of Wriezen were deported and murdered between 1940 and 1945. The victims are commemorated in the public database of the Yad-VaShem Memorial in Jerusalem. There has been a jewish cemetery in Wriezen since 1730, in which 131 gravestones still survive today. The oldest dates back to 1773, the last is from 1940.
Heidenhain, Brigitte. "Juden in Schwedt : ihr Leben in der Stadt von 1672 bis 1942 und ihr Friedhof." Universität Potsdam, 2010. http://opus.kobv.de/ubp/volltexte/2010/4158/.
Повний текст джерелаFor 270 years there was Jewish life in the Brandenburg town of Schwedt on the Oder. The reader of this volume participates in the changing history of the Jewish people and their community. The first Jew to settle in Schwedt in the 17th century was Bendix Levi. After his house in Oderberg burned down, Kurfürst Friedrich Wilhelm granted him permission to take up residence in Schwedt. The Prussian Kings wanted only few Jews to live in small Brandenburg towns, so during the 18th century the Jewish community in Schwedt consisted of only three families whose heads were Bendix Levi, Simon Salomon and Wulff Salomon. Their life was dominated by the fight for residency and trade permits. Solidarity amongst each other was not always self evident, since the residency permit of one was often in real or imagined conflict with a permit for others. The extensive sources in archives in Berlin, Brandenburg and Jerusalem show intensely the consequences of the restrictive Prussian “Judenpolitik” on the life of Jews in Schwedt and they also give us insight into Jewish traditions and customs. We bear witness to a Jewish oath in the townhouse of Schwedt and take part in the ceremonial signing of a marriage treaty. The “Emanzipationsedikt” of 1812 finally made Jews into Prussian citizens and simplified their life by giving them freedom of settlement and trade. This resulted in considerable growth of the Jewish community in Schwedt which was also joined by the Jewish residents of the nearby town of Vierraden. The first of these new settlers in Schwedt was David Loewenheim from Tütz / Westprussia. No less than seven families from his hometown followed. There was also immigration from other towns, increasing the number of Jewish residents in Schwedt to 200 by the late 19th century. After about 1880 the community shrank again because many moved away, particularly to Berlin. Since 1840 Schwedt was the seat of a Rabbi. Nathan Hirsch Kuttner stayed in Schwedt until his retirement in 1895. Although this long sojourn might indicate an agreeable relationship between him and his community, this was certainly not the case in his first years. Kuttner had to fight for recognition by his community and even had to obtain a court order to collect his salary. The building of a new Synagogue in 1862 gave a new sense of cooperation to the community and calmed the struggles with the Rabbi. Under the impression of increasing anti-Semitism from the late 19th into the 20th century, the community joined organizations which attempted to resist anti-Semitic attacks. For example, in 1894 it joined the “Deutsch- Israelitische Gemeindebund” and in 1901 the “Verein zur Abwehr des Antisemitismus”. In 1922 the “Reuchlin Loge”, was formed within the “Independent Order of Bnai Brith”. Soon followed the fast and complete anihilation of the Jewish community in Schwedt by the national socialist mass murder. The Central Database of Shoah Victims' Names at Yad Vashem / Jerusalem preserves the memory of 71 murdered Jews of Schwedt who are known by name. Descendants of survivors are scattered to all parts of the world. Intensive genealogical research in cooperation with Peter Lowe from Hertford (UK), descendant of the Loewenheim family, and Yehuda Meinhardt (Israel), made it possible to reconstruct a number of family trees. The volume ends with a description of the Jewish cemetery and a record of the grave inscriptions. An entire documentation with photographs can be found in the Internet (www.uni-potsdam.de/juedische-friedhoefe).
Tritten, Katharina Barbara. "Gesundheitsfachfrauen in Ausbildung : ihr Rauchverhalten, ihr Wissen über die Tabakprävention und ihre berufsbedingten Einstellungen dazu /." Niederscherli : [s.n.], 2006. http://www.public-health-edu.ch/new/Abstracts/TK_05.04.07.pdf.
Повний текст джерелаSenft, Matthias. "Prozesskettenintegriertes sicheres Lochen von IHU-Bauteilen." Berlin Logos-Verl, 2009. http://d-nb.info/999661388/04.
Повний текст джерелаDietrich, Thie. "Versteht Ihr Handy IP? - Drahtlose Internetanbindung." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199800369.
Повний текст джерелаSchönbach, Renate. "Veränderungen im IgG–Subklassenprofil bei Tumorerkrankungen." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-107830.
Повний текст джерела(UPC), Universidad Peruana de Ciencias Aplicadas. "IHC y Tecnologias Moviles - SI385 201801." Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/623266.
Повний текст джерелаTramp, Martin. "Tachodreh - und niemand kann ihn erkennen." Saarbrücken VDM, Müller, 2004. http://deposit.d-nb.de/cgi-bin/dokserv?id=2872407&prov=M&dok_var=1&dok_ext=htm.
Повний текст джерелаKolb, Annika. "Portfolioarbeit : wie Grundschulkinder ihr Sprachenlernen reflektieren /." Tübingen : Narr, 2007. http://deposit.d-nb.de/cgi-bin/dokserv?id=2875517&prov=M&dok_var=1&dok_ext=htm.
Повний текст джерелаBaruah, Kavitha. "Structural biology of IgG Fc glycoforms." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:def683d3-aa06-41d9-9f28-29d21258bebe.
Повний текст джерелаEditorial, Comité. "Entrevista al Ing. Saúl Montoya Heredia." Civilizate, 2015. http://repositorio.pucp.edu.pe/index/handle/123456789/114661.
Повний текст джерелаKohlheim, Volker. "Die literarische Figur und ihr Name." Gesellschaft für Namenkunde e.V, 2007. https://ul.qucosa.de/id/qucosa%3A31518.
Повний текст джерелаГребенюк, В. О. "Академія IMG - школа вищої спортивної майстерності". Thesis, КНТУ, 2011. http://dspace.kntu.kr.ua/jspui/handle/123456789/6115.
Повний текст джерелаArnold, Klaus. "Qualitätsjournalismus die Zeitung und ihr Publikum." Konstanz UVK Verl.-Ges, 2008. http://d-nb.info/992160014/04.
Повний текст джерелаTanner, Debora. "Die minderjährige Mutter und ihr Kind." München AVM, 2009. http://d-nb.info/99639155X/04.
Повний текст джерелаPIRES, E. C. "Oswald (ing): Antropofagia, culturas e fronteiras." Universidade Federal do Espírito Santo, 2012. http://repositorio.ufes.br/handle/10/3266.
Повний текст джерелаA partir de uma abordagem que relaciona os estudos pós-coloniais e as teorias da tradução, este trabalho indaga o uso dos empréstimos linguísticos e estrangeirismos na poética de Oswald de Andrade como atos de tradução e crítica anti/pós-colonial. Categorias pós-coloniais oriundas das pesquisas de Edward Said, Homi Bhabha e Gayatri Spivak como a ruptura das fronteiras, a diferença como categoria enunciativa e a temporalidade do entre-lugar e questões como as metáforas da tradução e a intraduzibilidade em diálogo com a ampla fortuna crítica produzida sobre Oswald de Andrade no país fomentam uma análise minuciosa do gesto antropofágico nos textos literários O Manifesto Antropófago (2011) e Memórias Sentimentais de João Miramar (2004), que servem como corpus para análise. O resultado do trabalho aponta para a necessidade de inventariarmos em nossos debates pós-coloniais atuais uma razão antropofágica que lhe antecede e que permite revelar aspectos importantes do pós-colonialismo no Brasil.
Pires, Eloá Carvalho. "Oswald(ing): antropofagia, culturas e fronteiras." Universidade Federal do Espírito Santo, 2012. http://repositorio.ufes.br/handle/10/6426.
Повний текст джерелаBy considering an approach which relates postcolonial studies and translation theories, this study questions the use of linguistic loans and foreignisms in Oswald de Andrade s poetic productions as translation acts and anti/postcolonial critique. The postcolonial categories presented by researchers as Edward Said, Homi Bhabha and Gayatri Spivak namely, the rupture of frontiers, difference as an enunciative category and temporality in the in-between space and questions on translation metaphors and untranslatability, in dialogue with the rich critique produced on Oswald de Andrade, stimulate the careful analysis of anthropophagy in the literary texts taken as our corpus: O Manifesto Antropófago (2011) and Memórias Sentimentais de João Miramar (2004). The result of the present research stresses the need for considering, within our current postcolonial debates, the anticipation of this anthropophagic reasoning, thus revealing a better understanding of important postcolonial aspects in Brazil
A partir de uma abordagem que relaciona os estudos pós-coloniais e as teorias da tradução, este trabalho indaga o uso dos empréstimos linguísticos e estrangeirismos na poética de Oswald de Andrade como atos de tradução e crítica anti/pós-colonial. Categorias pós-coloniais oriundas das pesquisas de Edward Said, Homi Bhabha e Gayatri Spivak como a ruptura das fronteiras, a diferença como categoria enunciativa e a temporalidade do entre-lugar e questões como as metáforas da tradução e a intraduzibilidade em diálogo com a ampla fortuna crítica produzida sobre Oswald de Andrade no país fomentam uma análise minuciosa do gesto antropofágico nos textos literários O Manifesto Antropófago (2011) e Memórias Sentimentais de João Miramar (2004), que servem como corpus para análise. O resultado do trabalho aponta para a necessidade de inventariarmos em nossos debates pós-coloniais atuais uma razão antropofágica que lhe antecede e que permite revelar aspectos importantes do pós-colonialismo no Brasil
Rodrigues, Junior Valnês da Silva. "Avaliação pré-clínica dos compostos IQG-607 e IQG-639 em um modelo de tuberculose em camundongos." Pontifícia Universidade Católica do Rio Grande do Sul, 2012. http://hdl.handle.net/10923/4487.
Повний текст джерелаTuberculosis continues to be one of the deadliest diseases in the world. The emergence of drug-resistant strains of Mycobacterium tuberculosis, the unbearable side effects of the available drugs and the frequent patient non-compliance in completing the therapy have increased the need for development of new effective agents. We have previously demonstrated a potent in vitro inhibitory activity for two pentacyano(isoniazid)ferrate(II) compounds, namely IQG-607 and IQG-639 against the M. tuberculosis enoyl-ACP reductase enzyme. Importantly, IQG- 607 and IQG-639 were active against cultures of M. tuberculosis H37Rv and two isoniazid-resistant clinical isolates in vitro. In the present study, the activity of these compounds was evaluated by using an in vivo murine model of tuberculosis. Swiss mice were infected with M. tuberculosis H37Rv strain, and IQG-607 and IQG-639 (250 mg/kg) were administered during 28 or 56 days. As well, a dose-response study was performed with IQG-607 (at 5, 10, 25, 50, 100, 200 and 250 mg/kg). The activity of test compounds was compared with that of the positive control drug isoniazid at 25 mg/kg. After 28 or 56 days of treatment, either IQG-607 or isoniazid significantly reduced M. tuberculosis-induced splenomegaly, and also significantly diminished the colony-forming units in both spleens and lungs. IQG-607 or isoniazid ameliorated the lung macroscopic aspect, reducing the lung lesions to a similar extent. However, IQG-639 was not capable of significantly modifying any evaluated parameter. IQG-607 did not display a classical dose-dependent profile in our murine model of tuberculosis, and 10 mg/kg was the lowest dose able to show significant activity, which was similar to the inhibition observed for higher doses. In addition, experiments using early and late controls of infection revealed a bactericidal activity for IQG-607 in our model. The promising activity of IQG-607 in M. tuberculosis-infected mice suggests that this compound might represent a good candidate for clinical development as a new antimycobacterial agent.
A tuberculose é uma das principais causas de morte no mundo. O surgimento e disseminação de cepas de Mycobacterium tuberculosis resistentes a fármacos, os efeitos indesejáveis dos fármacos atualmente disponíveis e a falta de adesão dos pacientes ao tratamento têm aumentado a necessidade do desenvolvimento de novos agentes anti-tuberculose. Estudos prévios revelaram uma potente atividade inibitória in vitro de dois compostos pentaciano(isoniazida)ferrato(II), denominados IQG-607 e IQG- 639, frente a enzima enoil-ACP redutase de M. tuberculosis. Ainda, o IQG- 607 e o IQG-639 foram ativos quando testados em culturas de M. tuberculosis H37Rv e sobre dois isolados clínicos resistentes à isoniazida in vitro. Neste trabalho, a atividade destes dois compostos foi avaliada in vivo, utilizando um modelo murino de infecção por M. tuberculosis. Camundongos suíços foram infectados com a cepa de M. tuberculosis H37Rv e o IQG-607 ou o IQG-639 (250 mg/kg) foram administrados aos animais durante 28 ou 56 dias. Adicionalmente, um estudo de dose-resposta foi realizado com o composto IQG-607, empregando as doses de 5, 10, 25, 50, 100, 200 e 250 mg/kg. As atividades dos compostos-teste foram comparadas à atividade da isoniazida (25 mg/kg), o controle positivo do tratamento. Após 28 ou 56 dias de tratamento, tanto o IQG-607 quanto a isoniazida reduziram significativamente a esplenomegalia induzida pela infecção e, também, diminuíram as unidades formadoras de colônia, tanto nos pulmões quanto nos baços dos animais tratados. O IQG-607 e a isoniazida melhoraram o aspecto macroscópico dos pulmões, reduzindo as lesões pulmonares de maneira semelhante. Por sua vez, o IQG-639 não foi capaz de modificar significativamente nenhum parâmetro avaliado neste estudo. O IQG-607 não apresentou um perfil clássico de dose dependência, sendo observada atividade inibitória significativa similar, entre as doses de 10 mg/kg e 250 mg/kg. Além disto, um experimento utilizando um “controle pré-tratamento” demonstrou que o IQG-607 possui atividade bactericida no nosso modelo. A atividade satisfatória do IQG-607 em camundongos infectados com M. tuberculosis sugere que este composto pode ser um candidato promissor no desenvolvimento clínico de um novo agente antimicobacteriano.
Cerný, Jirí [Verfasser]. "Die Flugschriften der Frühreformation aus Nord- und Nordwestböhmen : Ihr Wesen und ihr Bezug zu Wittenberg / Jirí Cerný." Frankfurt a.M. : Peter Lang GmbH, Internationaler Verlag der Wissenschaften, 2021. http://d-nb.info/1236117166/34.
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