Дисертації з теми "IgE mediated allergy"
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Grönlund, Hans. "Diagnosis and treatment of IgE-mediated allergy : new approaches using recombinant allergens /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-373-6/.
Повний текст джерелаPalosuo, Kati. "IgE-mediated allergy to dietary gliadin studies on wheat-dependent, exercise-induced anaphylaxis and childhood wheat allergy." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/palosuo/.
Повний текст джерелаMarknell, DeWitt Åsa. "Use of Recombinant Allergens for Component-Resolved Diagnostics (CRD) in IgE-Mediated Allergy." Doctoral thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7813.
Повний текст джерелаImmunoglobulin E (IgE)-mediated allergy occurs when our immune system causes a reaction to otherwise harmless substances (allergens). Allergens are predominantly proteins present in biological materials such as pollens, mites, animal epithelia, moulds and foods.
In vitro tests for specific IgE antibodies usually employ an allergen source extract as an antibody capturing reagent. The proportion of allergenic molecules in these biochemically complex extracts may vary.
Recombinant allergens may be obtained in large quantities with biotechnological techniques. These proteins can be characterized biochemically and immunologically, resulting in tests with minimal batch-to-batch variation. This thesis describes different uses of recombinant allergens in component-resolved diagnostics (CRD).
In CRD, single allergenic proteins are used to establish a sensitization profile of the patient. Two timothy grass (Phleum pratense) pollen allergens, Phl p 11 and Phl p 4, were cloned and expressed as recombinant proteins. They were subsequently characterized and can, for example, be used in a panel for grass pollen CRD.
Single allergens may be useful as diagnostic markers for allergic sensitization. This phenomenon was studied using tropomyosin, a major allergen from the shrimp Penaeus aztecus (Pen a 1). The characteristics of the recombinant and natural proteins were compared. The recombinant tropomyosin was then extensively tested using specific competition for IgE binding against extracts of other crustacean species, house dust mite and cockroach.
In cases when an important allergen is missing or underrepresented in a natural extract, the corresponding recombinant allergen may be added to the extract as a spiking reagent. Previous studies have shown that latex extracts for diagnostic testing may lack the allergen Hev b 5. Recombinant Hev b 5 was expressed from a synthetic gene construct, incorporating several adaptations to enable efficient large scale production of the recombinant protein, to be used as a spiking reagent.
Marknell, DeWitt Åsa. "Use of recombinant allergens for component-resolved diagnostics (CRD) in IgE-mediated allergy /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7813.
Повний текст джерелаYamani, Amnah. "Dysregulation of Vascular Endothelial Function Modulates Severity of IgE-mediated Anaphylactic Reactions." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490350649626552.
Повний текст джерелаYahya, Mohd Norhakim. "Analysis of the IgE network : inhibition of CD23-mediated IgE upregulation and CD21/C3d interaction." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:bc5ff165-2d2c-4e4f-a0e9-5651cacd2ddf.
Повний текст джерелаGray, Claudia Liesel. "The prevalence and patterns of IgE-mediated food allergy and sensitisation in South African children with atopic dermatitis." Doctoral thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/12874.
Повний текст джерелаBackground: The prevalence of food allergy in South Africa is unknown, but previously thought to be low, particularly in black South Africans. We hypothesised that food allergies would be low in Xhosa patients, even those at increased risk of food allergy such as children with atopic dermatitis (AD). This study aimed to determine the prevalence of, patterns and risk factors for, IgE-mediated food allergy in South African children with moderate to severe AD. It is the first food allergy prevalence study in South Africa to utilise controlled food challenges and component analysis, and is unique for its comparison of food allergy patterns between ethnic groups in the same geographical area. Methodology: This was a prospective, observational study in a paediatric university hospital in Cape Town. Children with moderate to severe AD, aged 6 months to 10 years, were randomly recruited from the dermatology clinic. They were assessed for sensitisation and allergy by questionnaire, skin prick tests (SPT), Immuno Solid Phase Allergen Chip (ISAC) test and incremental food challenges. Sensitised patients were also tested for specific IgE by ImmunoCAP test. Results: One hundred participants (59 black Africans and 41 of mixed race) were enrolled, median age 42 months. There were high overall rates of food sensitisation (66%) and food allergy (40%). Egg (25%) and peanut (24%) were the most common allergies. Black participants had comparable sensitisation (69% vs 61%) but lower allergy rates (34% vs 46%) than mixed race participants. This was especially evident for peanut allergy (15% vs 37%, p=0.01). Early onset AD (< 6 months), severe eczema, and young age < 2 years were significant risk factors for food allergy. The ISAC test was less sensitive than SPT and ImmunoCAP tests. Only 42% of cases of perceived food allergy were confirmed as true food allergy.
Rolf, Sofia, and Johanna Svensson. "Den dolda funktionsnedsättningen – att leva med IgE-medierad födoämnesallergi : Erfarenheter och uppfattningar av att leva med en folksjukdom." Thesis, Högskolan i Halmstad, Akademin för hälsa och välfärd, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-36067.
Повний текст джерелаFood allergy is a hidden disability that does not become visible until the individual develops an allergic reaction. From there on it can quickly become a matter of life or death. The physical response has been well researched and yet how the disease affects the patient’s life situation is relatively unexploded. Nursing literature regarding allergy risks and interventions mention little about food allergy. The aim of the study was therefore to highlight patients’ experiences and perceptions of living with IgE-mediated food allergy. Through a literature study four themes emerged: Fear and loss of security, Managing everyday life, Importance of information regarding labeling of food and The importance of support from others. The experience of not having control, a constant risk of unsuspected reactions, not always having an understanding from others and having to defend their needs gave a negative emotional response. The way back to an ordinary living consisted of strategies, understanding and reconciliation, yet there were still obstacles left in the environment. The knowledge of this study can be used in caring for a food allergic patient without jeopardizing healing process and feeling of security. The society needs to meet the patient group’s needs through adaptation, to achieve quality of life.
Larsson, Anna-Karin. "Early life cytokines, viral infections and IgE-mediated allergic disease." Doctoral thesis, Stockholm : Wenner-Gren Institute for Experimental Biology, Stockholm university, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1224.
Повний текст джерелаPowe, Desmond George. "Do some subjects with idiopathic rhinitis have an allergic inflammatory disease mediated by IgE, in their nasal mucosa?" Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408604.
Повний текст джерелаWickrama, Gunaratne Anoja. "Effects of n-3 LCPUFA supplementation for pregnant and lactating women in preventing allergic diseases in early childhood." Thesis, 2015. http://hdl.handle.net/2440/115480.
Повний текст джерелаThesis (Ph.D.) -- University of Adelaide, School of Medicine, 2015.
施宛吟. "Investigation of the molecular mechanism underlying anti-allergy activity of the ethanol extract of Cordyceps militaris fruit body grown on silkworm pupa toward IgE-mediated allergic response." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/s2r9ff.
Повний текст джерелаLin, Huey-Jun, and 林惠君. "In vitro assessment of curcumin on IgE-mediated allergic responses." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/11842773964305722430.
Повний текст джерела國立臺灣海洋大學
食品科學系
93
Abstract Allergy owing to inappropriate immune responses to antigen in the environment. Asthma, allergic rhinitis and atopic dermatitis are common diseases which all belong to Type I allergic responses (so called IgE-mediated allergic responses). In recent study, it shows higher relationship between ROS and allergic responses. Curcumin is a major yellow pigment isolated from the spice turmeric. Dietary curcumin possesses an anti-oxidant and anti-inflammatory properties and it also exhibits significant chemopreventive activity. Rat basophilic leukemia cells (RBL -2H3) express α, β and γ chain of Fc�悐I, which plays a major role in the IgE-mediated allergic response. Antigen-IgE crosslinking initiates the release of ��-hexosaminidase, which is a marker of degranulation in RBL-2H3. Curcumin shows activity against ��- hexosaminidase release from IgE-mediated at 5 �嵱, even effective in calcium ionophores (A23187)-induced degranulation at��10 �嵱. Furthermore, effects of curcumin on antigen/A23187 induced release of histamine were also examined, both of them were decreased accompanied with the increasing concentration of curcumin. Among IgE-mediated allergic responses, antigen induces mast cells intracellular ROS production significantly. Curcumin could reduce ROS production from IgE-mediated or A23187 induced at 5 �嵱, and inhibits PKC-�� translocation from cytosolic to particulate. Fc�悐I consists of four subunits (������2), and the �� chain is high affinity to IgE. The surface expression of Fc�悐I in human basophilic cell line (KU812) also studied, treating with dose-dependent curcumin expresses lower level of mRNA expression of Fc�悐I ���nand ���nchain. Even 10 �嵱 curcumin could also suppress IL-4/IL-13 mRNA expression. And all above, these results suggest that curcumin can alleviate the IgE-mediate allergic responses through down-regulating Fc�悐I expression and reducing the production of the allergic mediates and ROS. Key words: Curcumin, IgE-mediated allergic responses, degranulation, ROS, PKC-���z Fc�悐I
Hung, Hsing-Wen, and 洪幸彣. "In vitro assessment of astaxanthin on IgE-mediated allergic response using cultured cell lines." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/38312231622655940147.
Повний текст джерела國立臺灣海洋大學
食品科學系
95
Astaxanthin (AST), a non-pro-vitamin A carotenoid, is abundant in aquatic animals such as crab, shrimp etc. It possesses some pharmacological activities, including anti-inflammatory, anti-oxidative and immunomodulatory properties. IgE-mediated allergy owing to hyper-reactive immune responses to antigen in the environment. It shows high relationship beteewn reactive oxygen species (ROS) and allergic response through modulating intracellular signal transduction pathway. These actions cause the process of degranulation of mast cells resulting in the release of allergic mediators. In this report, we investigate the anti-allergic effect of AST and its possible mechanisms. The allergic model is established by RBL-2H3 and KU812 cells that sensitized by antigen and calcium ionophore (A23187). The results prove 100 uM AST inhibits 30 % of intracellular Ca+2 influx and almost abolished protein kinase C (PKC) phosphorylation and 40 % of ROS generation. Treating with 10-100 uM AST inhibits 20 % of histamine, b-hexosaminidase release. Expression the receptor for IgE (FceRI) is only inhibited by treating with high concentration (300 uM) AST. AST significantly reduce of IL-4 release at 100 uM and the IC50 for mitogen-activated protein kinases (MAPK) at 30 uM. And all above, these findings elucidate that astaxanthin can alleviate the IgE-mediate allergic response major by down-regulating ROS generation, reducing intracellular signaling pathways (Ca+2 influx, PKC and MAPK) and chemical mediators (histamine, b-hexosaminidase and IL-4) release. Key words: Astaxanthin, IgE-mediated allergic responses, mast cell, degranulation, basophil
Jin, C., CP Shelburne, G. Li, EN Potts, KJ Riebe, GD Sempowski, WM Foster, and SN Abraham. "Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation." Thesis, 2011. http://hdl.handle.net/10161/2358.
Повний текст джерелаDissertation
CHIU, YI-CHEN, and 邱怡真. "Molecular effects of ethanol extract from pupa-cultivated Cordyceps militaris (L.) fruit bodies on IgE-mediated allergic rhinitis." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/r2yk6f.
Повний текст джерела南臺科技大學
生物科技系
106
In recent years, the deterioration of air and the environment has led to moreallergic patients, e.g. allergic rhinitis, asthma and contact dermatitis etc.Recently many studies indicate that the active compounds and pharmacological of C. militaris is even higher and better than that of C. sinensis so that C. sinensis is gradually taken place by C. militaris. Besides, many researchers also apply C. militaris to alleviate the symptoms of various diseases. The results of this study indicated that ethanol extract from silkworm pupa-cultivated C. militaris fruit bodies (CM_EE) could inhibit symptoms of IgE-mediated allergic rhinitis in BALB/c mice. Therefore, we investigated more about the inhibition molecular mechanisms of CM_EE. CM_EE treatment showed the ability to inhibit degranulation in the dose-dependent way. Additionally, CM_EE incubation decreased intracellular calcium influx. Further western immunoblotting results demonstrated that CM_EE incubation could interfere with the activation of Bruton Tyrosine Kinase、Protein Kinase C、p38 mitogen activated protein kinase and 14-3-3γ while promoted the phosphorylation of Eukaryotic translation initiation factor 2 subunit 1 and Peroxisome proliferator-activated receptor γ protein expression. The above results implicated that CM_EE treatment could regulate FcεRI signaling pathway, intracellular calcium level and degranulation to decrease cytokine secretion and thus alleviate allergic rhinitis. In conclusion, CM_EE might be a potential Chinese herbal drug for curing allergy.