Дисертації з теми "IgAN"
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Mohey, Hesham. "Le risque rénal absolu (RRA) de dialyse ou décès chez les patients adultes avec néphropathie à IgA primaire (NIgA) : étude d'une cohorte prospective de néphropathie à IgA recrutée à Saint-Etienne (IGAN -STET-CO)." Phd thesis, Université Jean Monnet - Saint-Etienne, 2010. http://tel.archives-ouvertes.fr/tel-00675243.
Повний текст джерелаMohey, Hesham. "Le risque rénal absolu (RRA) de dialyse ou décès chez les patients adultes avec néphropathie à IgA primaire (NIgA) : étude d’une cohorte prospective de néphropathie à IgA recrutée à Saint-Etienne (IGAN -STET-CO)." Thesis, Saint-Etienne, 2010. http://www.theses.fr/2010STET010T/document.
Повний текст джерелаFor the individual patient with primary IgA nephropathy (IgAN), it remains a challenge to predict accurately the long term outcome at 10 and 20 years after disease onset. We studied it in a prospective cohort of 332 (237 males, 71.4%) biopsy-proven IgAN patients, the IGAN-STET-CO, aged at diagnosis of mean = 41.4 (SD=15.1) years, with a total exposure time of mean = 12.9 (9.5) y. Using three consensual risk factors (RF) simplified as dichotomous covariates : occurrence of hypertension, proteinuria ≥1 g/d, and severe pathological lesions (global optical score ≥8), we calculated an absolute renal risk (ARR) of dialysis/death (D/D), in analogy to the absolute cardiovascular risk. The ultimate prediction according to the number of RF present at diagnosis (ARR score: 0, 1, 2, or 3) was done by the Cox regression and the Kaplan-Meier survival methods. Overall, this ARR scoring permitted significant (P<0.0001) stratification of the risk. The cumulative incidence rate of D/D events (N=45), respectively at 10 and 20y, was 2 and 4% for ARR=0 (45.5% of all cases), 2 and 9% for ARR=1 (20.8%), 7 and 18% for ARR=2 (19.6%), and 29 and 64% for ARR=3 (N=47; 14.1%) in adequately treated patients. Effective control of hypertension and reduction of proteinuria improved survival without D/D when achieved. This absolute renal risk score evaluated at diagnosis, allowed accurate prediction of ultimate dialysis/death risk and was also validated in another cohort. This is a significant progress in the management of the individual patient with lgA nephropathy
Gomes, Michelle Marie. "Molecular characterization of IgA1-receptor interactions implicated in IgA nephropathy." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1242938515.
Повний текст джерелаWehbe, Batoul. "IgA et rein : destructrice ou protectrice ? : Rôles de l'immunoglobuline A (IgA) dans deux pathologies rénales." Thesis, Limoges, 2018. http://www.theses.fr/2018LIMO0034/document.
Повний текст джерелаImmunoglobulin A (IgA) is the most synthetized immunoglobulin in mammals. IgA has ambivalent properties: it is implicated in the mechanisms of defense against pathogens but also in the immune tolerance of commensal microbiota. However, IgA can develop pathogenic properties. In the first part of my thesis, we studied the pathogenic effects of IgA. IgA deposits are the main characteristic of IgA nephropathy (IgAN). IgAN physiopathology is not yet clearly understood. The hypothesis of a glycosylation defect is strongly adapted. This defect can be due to IgA polymerization or antigenicity. It can also induce shedding of CD89 (IgA Fc receptor) or other factors. We studied the effect of variable region altered affinity, the light chain substitution and the association of IgA with CD89 on the development of kidney lesions and impairment of kidney function in four mouse models followed up during 12 months. In addition, we studied the physico-chemical properties of 28 IgA purified from patients with dysglobulinaemia and 28 chimeric IgA produced by hybridomas. The effect of these properties on the propensity of IgA for mesangial deposition was explored. In the second part, we studied the immunomodulatory and anti-inflammatory properties conferred by the overexpression of human IgA in a mouse model with systemic lupus (MRL/lpr model). In the last part, we contributed to the characterization of a transgenic mouse model producing IgA class 2 and to the study of the effect of IgA2-mediated signaling on B lymphocyte development. Altogether, obtained results show the pathogenic effect of low affinity-IgA on the development of IgA nephropathy. In addition, different analyses showed that molecular stability but not glycosylation profile is the determining factor for IgA deposition. On the other hand, IgA expression in lupus-prone mice extended their survival, delayed the onset of auto-immunity and ameliorated kidney functions in these animals which supports IgA anti-inflammatory properties. The study of IgA2-mediated signaling in the transgenic model showed the inhibitory effect of IgA2 on the early development of several B cell sub-populations. All of these results show the multiple effects of IgA which contribute on one hand to the pathogenesis of a complex disease (IgAN) and on the other hand to protection from autoimmunity, demonstrating the complexity of interactions and the regulatory character of this immunoglobulin
Günther, Ellen. "Examen igen?" Thesis, Södertörn University College, Lärarutbildningen, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-1999.
Повний текст джерелаThis paper will discuss the proposed reintroducing of a final degree in upper secondary school. In a public government inquiry that was released in March 2008 a proposal about reintroducing a final degree in upper secondary school was presented. A final degree has not been a part of the upper secondary school science 1968. Why was the system with a final degree abounded and why do the government want to reintroduce it?
Research in pedagogy has through the years presented numbers of theories about assessment. In last decades a great part of the discussion has been focused on formative assessment. In formative assessment the assessment is used as a pedagogy tool. The purpose is to help the student develop their learning process and to learn to work independently. The contrary to formative assessment is assessment which only purpose is to summarise and control the level of knowledge a student possesses.
The public government inquiry that led to abolish of a final degree in upper secondary school in 1968 shared many thoughts with theories about formative assessment. Forty years later the government has grown sick of all the formative assessment, which they think has led to a “muddled” school. The public government inquiry presented in 2008 wants to reintroduce a final degree and create a school where the student’s knowledge is orderly controlled and summarised.
Layward, Lorna. "IgA in IgA nephropathy." Thesis, University of Leicester, 1992. http://hdl.handle.net/2381/34129.
Повний текст джерелаAllen, Alice. "IgA glycosylation in IgA nephropathy." Thesis, University of Leicester, 1995. http://hdl.handle.net/2381/35028.
Повний текст джерелаMattsson, Madeleine, and Emma Liljefeldt. "MKB Vågade - igen?" Thesis, Malmö högskola, Fakulteten för kultur och samhälle (KS), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-21945.
Повний текст джерелаWallin, Pérez Carolina. "Snurra min jord igen." Thesis, Kungl. Musikhögskolan, Institutionen för jazz, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kmh:diva-105.
Повний текст джерелаMillet, Isabelle. "Récepteurs pour les IgA et propriétés biologiques des facteurs liant les IgA : iga-bf." Lyon 1, 1988. http://www.theses.fr/1988LYO1T156.
Повний текст джерелаMillet, Isabelle. "Récepteurs pour les IgA et propriétés biologiques des facteurs liant les IgA (IgA-BF)." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37616528s.
Повний текст джерелаLeung, Chi-kam Joseph, and 梁志錦. "The pathogenesis of IgA nephropathy: the roleof IgA molecule and the nature of IgA receptors." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29744908.
Повний текст джерелаOlsson, Johan. "Kvinnan kan du sälja igen och igen och igen, tills hon är död : En studie om fem svenska organisationer som diskuterar fenomenet trafficking." Thesis, Linköping University, Centre for Gender Studies, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-8259.
Повний текст джерелаKvinnan kan du sälja igen -och- igen -och- igen, tills hon är död.
Så säger Iluta Laca, ordförande i Martacenter i Riga och en av deltagarna på Palmedagarna i Västerås under hösten 2005. Laca arbetar med att hindra att flickor hamnar i trafficking men även med att rehabilitera redan utsatta.
Trafficking är inget nytt fenomen, redan under 1800-talets senare hälft fanns det prostituerade från Europa i Buenos Aires och i Indien. Detta kallas för den ”vita slavhandeln”. Den ersattes senare av den ”svarta slavhandeln” som kan delas in i fyra vågor och handlar om kvinnor som kommit till västvärlden. I den första vågen kom kvinnorna från Asien, i den andra från Sydamerika och i den tredje från Afrika. Nu i den fjärde vågen kommer kvinnorna från Central- och Östeuropa. Det fanns knappast några kvinnor från dessa länder före 1992. Enligt FN kan så många som 2 miljoner människor per år falla offer för trafficking. Uppskattningsvis tjänar de kriminella grupperna 7 miljarder dollar per år på verksamheten. Då handlar det inte bara om trafficking för sexuella syften utan t.ex. även arbetskraftsexploatering. Vinsterna i trafficking är jämförbara med smuggling av droger och vapen. Den stora förtjänsten med trafficking, både den i sexuellt syfte och arbetskraftsexploatering, ligger bland annat i att människor kan säljas om och om igen.
Den här uppsatsen handlar om hur fem olika organisationer i Sverige diskuterar fenomenet trafficking av kvinnor för sexuella ändamål. Det empiriska materialet i studien består av intervjuer med representanter från organisationerna Kvinna Till Kvinna, Kvinnoforum, Palmecentret, Riksförbundet för sexuell upplysning (RFSU) och Riksorganisationen för kvinnojourer och tjejjourer i Sverige (ROKS). Även tryckt material från organisationerna som tar upp fenomenet finns med i empirin.
Kamata, Tadashi. "Increased frequency of suldace IgA-Positive Plasma cells in the intestinal lamina propria and decreased IgA excretion in hyper IgA(HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA." Kyoto University, 2000. http://hdl.handle.net/2433/151436.
Повний текст джерелаDarnell, Tey Alejandro. "Nefropatía mesangial IgA." Doctoral thesis, Universitat de Barcelona, 1988. http://hdl.handle.net/10803/2340.
Повний текст джерелаEn ella se analiza la historia clínica y la biopsia renal de 100 pacientes, 77 adultos y 23 niños, diagnosticados de nefropatía entre septiembre de 1975 y diciembre de 1986 en el Servicio de Nefrología del Hospital Clínico de Barcelona. El diagnóstico se fundamenta en el hallazgo de depósitos aislados o predominantes de inmunoglobulina A en el mesangio glomerular. Se excluyen los pacientes con evidencia clínica o serológica de lupus eritematoso sistémico, enfermedad hepática crónica o púrpura de Schönlein-Henoch. Durante este período se efectúan un total de 1754 biopsias renales, 639 de las cuales son diagnosticadas de enfermedad glomerular primitiva (39,2%). Entre estas últimas biopsias, 112 reúnen los criterios de nefropatía IgA, lo que representa un 17,5 %, y se descartan 12 pacientes que no reúnen las condiciones requeridas en el presente estudio. El material histológico se obtiene por biopsia renal quirúrgica o percutánea y es procesado para microscopía óptica (MO) e inmunofluorescencia en todos los casos. Además se procesa para microscopia electrónica (ME) en 20 casos. Las biopsias se clasifican según el sistema propuesto por la OMS para las enfermedades glomerulares y que distingue 5 tipos histológicos: (I) Riñón normal, (II) Cambios menores, (III) GN segmentaria y focal, (IV) GN proliferativa difusa, y (V) GN esclerosante. Los datos se expresan utilizando media aritmética y la desviación estándar. En el análisis estadístico se emplea la "t" de Student, la prueba del X(2) y en ocasiones un método paramétrico. El deterioro de la función renal se valora mediante el coeficiente de regresión de los recíprocos de creatinina sérica (l/Cr) versus tiempo de evolución. La supervivencia renal se calcula con el método de las tablas de vida de Cutler y Ederer.
La serie de pacientes adultos consta de 77 casos, 57 varones y 20 mujeres (2,8/1). La edad de inicio 26 +/- 10 años (entre 15 y 50) y la edad al efectuar la biopsia 31 +/- 10 (entre 15 y 56). Existe un antecedente familiar de nefropatía en el 14,5% de los casos y 2 pacientes son hermanos. Las formas de presentación son: hematuria macroscópica en 37 pacientes (48%), proteinuria y/o microhematuria en 21 (27,3%), hipertensión arterial en 15 (19,5%), insuficiencia renal en 2 (2,6%), síndrome nefrítico agudo en 1 (1,3%) y síndrome nefrótico en 1 (1,3%). No se observan diferencias relacionadas con el sexo. En el momento de biopsia muestran proteinuria 70 pacientes (91%) y hematuria microscópica 62 de 69 (90%). Un total de 39 pacientes se hallan hipertensos (50,6%) y 11 presentan HTA maligna. Asimismo, 25 pacientes muestran una creatinina sérica (Cr) superior a 1,4 mg/dl y el aclaramiento de Cr es inferior a 70 ml/min en 29 de 62 pacientes. El nivel sérico de IgA se determina en 35 pacientes, siendo en 11 de ellos superior a 400 mg/dl (31,4%). Los niveles de C3 y C4 y la actividad CH(50) son normales y el antígeno HBsAb en todos los casos estudiados.
En la biopsia renal de pacientes adultos, las lesiones más constantes en MO son la proliferación (83%) y la expansión mesangial (100%). Las lesiones sobreañadidas (semilunas, adherencias y esclerosis) son frecuentes pero en general afectan un bajo porcentaje de glomérulos. Existe una asociación muy estrecha entre fibrosis intersticial, atrofia tubular y esclerosis glomerular (p=0,0005). La BR clasificada de tipo I: 0 casos (0%), tipo II: 13 casos (16,7%), tipo III: 35 (45,5%), tipo IV: 27 casos (35%) y tipo V: 2 (2,6%). En el examen por IF la IgA es constante y es la única inmunoglobulina presente en 35 casos (45,6%). La IgA tiene una localización mesangial en 55 casos y mesangial y capilar en los 22 restantes. Se detecta C3 en los glomérulos de 74 biopsias (96%) y fibrinógeno en 22 (28,6%). El examen por ME muestra depósitos en todos casos y depósitos subendoteliales en 5 de 13 casos.
La evolución es conocida en 67 pacientes adultos. La duración media del seguimiento ha sido de 3,7 +/- 3 años. Al final, 4 pacientes se hallan en remisión clínica (5,9%), 24 permanecen estables con función renal normal (35,8%), 4 desarrollan HTA no preexistente (5,9%) y los 35 restantes muestran una función renal deficiente, con Cr superior a 1,4 mg/dl (52,2%). En 18 se ha valorado la velocidad de insuficiencia renal calculando la pendiente de la línea de regresión de l/Cr sérica. En 5 es nula (inferior a 1 x 10(-3), en 6 muestra un lento deterioro (entre 1 y 8,3 x 10(-3) y en los 7 restante el deterioro es rápido (superior a 8,3 x 10(-3). Entre 44 pacientes con función renal normal en el momento de BR, 32 evolucionan de modo favorable y 12 de modo desfavorable. No se observan diferencias relacionadas con la edad o el sexo, pero son factores de mal pronóstico la ausencia de una historia recurrente y el hallazgo de proteinuria superior a 1 gr./24 h. Al comparar las lesiones histológicas, sólo es significativa una mayor incidencia de proliferación y de expansión mesiangial en los pacientes con evolución desfavorable. La probabilidad de supervivencia renal es del 93% a los 5 años, del 75% a los 10 años, del 70% a los 15 años y del 64% a los 20 años del inicio de los síntomas. La supervivencia renal es mejor en los pacientes con historia de hematuria recurrente, proteinuria inferior a 1g/24 h, hipertensión, con Cr sérica inferior a 1,4 mg/dl en el momento de la BR o con tipos histológicos II y III.
Asimismo se estudian 23 niños con nefropatía IgA (13 varones y 10 hembras) con una edad media de 10 +/- 3 años. La presentación común ha sido la hematuria macroscópica en 18 casos (78,3%), la cual tiene un carácter recurrente en 13 (56,7%). La nefropatía IgA muestra en la infancia un perfil clínico más benigno que en el adulto y caracterizado por la ausencia de HTA y de IR en el momento del diagnóstico. El patrón histológico es también menos severo, que se objetiva un tipo I en 4 casos (17,4%), un tipo Il en 7 (30,4%), un tipo lII en 9 (29,1%) y un tipo IV en sólo 3 (13%). Al final del seguimiento (media 4,2 +/-3 años) 6 niños se hallan en remisión (31.6%), 11 permanecen estables (57,9%) y sólo 2 muestran un discreto deterioro de la función renal (10,5 %).
Un total de 26 adultos con nefropatia IgA (33,8%) cursa con hematuria A recurrente (HR). La edad de inicio (21,3 +/- 2 años) y en el momento de la BR (28,4 +/- 8 años) es inferior la del resto de pacientes. El porcentaje de casos con proteinuria superior a 1 gr/ 24 h. (42%) y con Cr sérica superior1.4 mg/dl es menor. BR muestra en el 80% un tipo II o III y sólo en el 20% un tipo IV. Al final del seguimiento, la función renal es deficiente en el 27,3% de los casos con HR y sólo 3 pacientes se hallan en hemodiálisis. Sin embargo, cuando los pacientes con o sin HR se comparan para una edad media de 32 años, no hemos observado ninguna diferencia significativa en los niveles de Cr sérica, porcentaje de casos con Cr superior a 1,4 mg/dl o incidencia de hipertensión arterial.
Entre un total de 77 pacientes adultos, 11 muestran HTA maligna secundaria en el momento del diagnóstico (14,3%). Diez son varones y la edad media al efectuar la BR es 35,6 +/- 3 años. Ocho tienen una TA distólica igual o superior a 140 mm Hg. Cinco muestran muestran edema de papila y el resto retinopatía grado IIl. En 5 existe un antecedente de hematuria macroscópica. La proteinuria es superior a 1 g/24 h en todos los casos (media 4 +/-3g/24 h) y la Cr sérica varía entre 2,3 y 12 mg/dl (media 4,6 +/-3 mg/dl). La BR muestra una nefropatía IgA tipo III en 3 casos y tipo IV en los 8 restantes. Cuatro presentan necrosis fibrinoide y tres endoarteritis proliferativa. Todos reciben tratamiento hipotensor y sólo tres continúan hipertensos. Al final del seguimiento (media 18 +/- 12 meses), 7 se hallan en hemodiálisis. Estos 11 pacientes se comparan con 10 pacientes diagnosticados de HTA maligna "esencial" en el mismo período de tiempo y con una BR. Los hallazgos clínicos o analíticos no permiten el diagnóstico diferencial entre ambos grupos y se concluye que la BR es imprescindible para descartar la nefropatía IgA en los sujetos con HTA maligna.
Finalmente se destaca que la nefropatía IgA puede tener carácter familiar y que dos casos cursan con IRA reversible durante un brote de hematuria macroscópica.
A retrospective study of 100 patients with IgA nephropathy was undertaken and the histological patterns correlated with the clinical features at the time of biopsy and the prognosis of the disease. The study included 77 adul (57 males and 20 females). The mean age at apparent onset was 26 +/-10 years and the mean age biopsy was 31 +/-10 years. The common clinical presentations in adults macroscopic hematuria (48 %), asymptomatic microhematuria and proteinuria (27,3%) and hypertension (19,5%). At time of biopsy, proteinuria of more than 1 g/day as found in 54 cases (70,2%), hypertension in 39 cases (50,6%) and impaired renal function, with serum creatinine of more than 1,4 mg/dl in 25 cases (32,5%). Malignant HTA was observed in 11 cases. The WHO morphological criteria used in classifying IgA neoprhaty showed zero patients (0%) with Class I disease (normal kidney),13 patients (16,1%) with Class II (minor changes), 35 patients (45,5%) with Class III (focal and segmental glomerulonephritis), 27 patients (35%) with Class IV (diffuse proliferative glomerulonephritis) and 2 patients (2,6%) with Class V (sclerosing glomerulonephritis). At the final examination, after a follow-up period of 3,7 +/- 3 years, 35 patients (52,2%) had impaired renal function. 14 of these patients went into terminal failure. Among patients with normal renal function at time of biopsy, progression to renal failure was more common in patients with 1) no history of recurrent gross hematuria, 2) proteinuria of than 1 g/day and 3) significant degree of enlargement and proliferation. The actuarial renal survival rate at year 10 after the onset was 75%, and at year 20 was 64%. Patients recurrent gross hematuria were younger, showed a low frequency of hypertension and impaired renal function at time of biopsy and had a more benign course. Malignant HTA in IgA nephropathy is commoner than previously reported and it presents in a fashion similar to that of malignant essential HTA. Therefore, given a case of malignant HTA, it is difficult to rule out IgA nephropathy if a renal biopsy is not performed. A comparative study of 23 children (mean age at biopsy 10 +/-3 years) was made. Children exhibited less severe histological picture and had a better prognosis than adults.
Andermyr, Jonas, and Lotta Johansson. "Att få igen för gammal ost." Thesis, Malmö högskola, Lärarutbildningen (LUT), 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-22216.
Повний текст джерелаMalmö is one of many municipalities in Sweden that are planning to adopt a system for collecting and handling the food waste generated within it. The goal is that at least 32 percent of the house owners within the municipality will choose to volunteer to sort out their food waste from 2009. To make their participation voluntary demands a high standard on the initial information campaign that VA SYD, the municipal corporation that is responsible for the collection, is planning to carry out with the purpose of getting as many house owners as possible to participate. This study has intended to, based on three focus group interviews with house owners from the districts of Djupadal, Kastanjegården and Riseberga in Malmö, identify what factors are influencing their willingness and opportunity to sort out their food waste. We then studied what barriers and opportunities those factors may involve if you by communicational means intend to influence Malmö’s house owners to voluntarily sort out their food waste long term. From our studies results you can deduce that an environmentally controlled waste tax with a lower fee for those who sort out their food waste is a strong incentive. How much lower is not important since it’s the principle that matters. It is important to give frequent feedback to the house owners in the form of substantial and intrinsic examples about what the collected food waste is used for, and what good it does for the environment. The containers are believed to be ugly and something that seizes up space. One way to create positive attention around the containers is to offer print on them. It is very important that the municipal council gives as good prerequisites as possible for the house owners to sort out their food waste. If the technical aspects of the system work well it signals credibility and seriousity and can motivate the house owners to do their part that is, sorting out their food waste. To convert negative attitudes within the house owners you should refer to experiences from other municipalities that are collecting food waste from house owners. By pictures and coverage’s with their house owners they can act as role models for Malmö’s house owners.
Cheung, Chee Kay. "The role of filtered IgA in the progression of IgA nephropathy." Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/39928.
Повний текст джерелаGustafsson, Johan, and Elin Lundgren. "Likviditetsfällan går igen : Fallet USA 2008/09." Thesis, Linköping University, Economics, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-18658.
Повний текст джерелаLikviditetsfällan är en ekonomisk anomali där expansiv penningpolitik blir verkningslös för att transmissionsmekanismen genom vilken penningmängdsökningar påverkar produktionen inte fungerar normalt. Makroteorin tenderar att bortse från de delar av teorin som krävs för att analysera likviditetsfällan. Det handlar främst om elasticiteten i efterfrågan på realbalans och hur den påverkar LM-kurvans lutning. Klassisk IS-LM-analys tenderar dessutom att inte betona den intertemporala dimensionen i konsumtions- och investeringsbeslut, vilket kan ha en avgörande betydelse vid en likviditetsfälla.
Mycket tyder på att den amerikanska ekonomin är på väg att fastna i en likviditetsfälla som – om den inte neutraliseras av en framgångsrik stabiliseringspolitik – kommer ha negativa effekter för hela världsekonomin.
Svalling, Karl, and Sofie Ekeroth. "Att inte känna igen sin egen spegelbild." Thesis, Hälsohögskolan, Högskolan i Jönköping, HHJ, Avd. för omvårdnad, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-30441.
Повний текст джерелаPapista, Christina. "Study of IgA receptors and transglutaminase 2 in IgA nephropathy and coeliac disease." Paris 7, 2013. http://www.theses.fr/2013PA077014.
Повний текст джерелаIgA nephropathy (IgAN), a major cause of renal failure Worldwide, is characterized by a complex pathogenesis, which consists of unknown factors favoring formation of macromolecular IgAl complexes in the circulation and complex deposition in the mesangium. IgA receptor abnormalities are implicated, including circulating complexes of IgAl with the soluble (s) form of the myeloid receptor CD89 and over-expression of the mesangial IgAl receptor TfRl (transferrin receptor 1). In the first part of this thesis, using a new IgAN mouse model expressing both human IgAl and CD89, w demonstrated that IgAl-sCD89 complexes initiated a process of auto-amplification involving over-expression of TfR and the cross-linking enzyme transglutaminase2 (TGase2), allowing increased mesangial deposition of pathogenic IgA complexes and chronic mesangial cell activation. Food antigens, notably gluten, are also associated with IgAN onset, bi the mechanism is still unknown. Inspired by a novel model of gluten-sensitized mice developed in the second part of this study showing the role of IgA, TGase2, TfRl and the intestinal microbiota in the induction of immune responses an coeliac-like disease induced by gluten, I concluded this thesis with a third part focused on the effect of gluten in IgA1 using the same sensitization method. I showed that gluten in association with CD89, was implicated in IgAl-sCD8 complex formation and exacerbating IgAl mucosal response, resulting in a breakdown of oral tolerance and IgA1 development. Crucial players: CD89, TfRl, TGase2 and gluten, emerge from this thesis, affecting both IgAN and coeliac disease and proposing new therapeutic targets for both pathologies
Posgai, Monica Therese. "Energetic and dynamic characterization of the IgA1:FcαRI interaction reveals long-range conformational changes in IgA1 upon receptor binding". University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1354043317.
Повний текст джерелаRao, Subba Chintalacharuvu. "Interleukins 4 and 5 alter IgA glycosylation: Ramifications for the pathogenesis of IgA nephropathy." Case Western Reserve University School of Graduate Studies / OhioLINK, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=case1062077056.
Повний текст джерелаGröndahl, Jessica, and Elin Jakobsson. "Nornan blomstrar igen : nybyggnation i kulturhistoriskt känslig miljö." Thesis, Linnéuniversitetet, Institutionen för teknik, TEK, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-19710.
Повний текст джерелаHolmqvist, Emanuelsson Gustaf. "Se mig, gilla mig och gör det igen." Thesis, Malmö universitet, Fakulteten för kultur och samhälle (KS), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-23779.
Повний текст джерелаThis study is about social media and in what ways it can give expression for a need ofconfirmation, by the individuals who are using it. By using qualitative interviews on five users of social media, combined with exploiting theories in self-representation, behaviourism and Uses and Gratifications, it was possible to discover several kinds of need for confirmation. Thus, three strategies in self-representation was being used: a strategy mainly for attention, a strategy to reach a specific target group, and a strategy for general need of confirmation. Furthermore, information on how the users are aware of the mechanisms from social media is being showed and also how they make the most out of it. Eventually, after their need for confirmation had been examined, the users’ feelings were presented.
Thufvesson, Anna, and Izabella Kolodziej. "När det är rast så leker vi igen." Thesis, Malmö högskola, Fakulteten för lärande och samhälle (LS), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-30719.
Повний текст джерелаMcDonald, Kenneth John. "Molecular mechanisms of IgA nephropathy." Thesis, University of Glasgow, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432870.
Повний текст джерелаPratt, Stephanie Ann. "Immunoglobulin A1 protease of Streptococcus pneumoniae." Thesis, University of Leicester, 1988. http://hdl.handle.net/2381/35410.
Повний текст джерелаGayet, Rémi. "Impact de la réponse IgA dans une nouvelle stratégie de vaccination muqueuse contre Salmonella et dans la régulation de la réponse adaptative." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSES015/document.
Повний текст джерелаThe enterobacteria Salmonella species are divided into several serovars such as Typhimurium, Enteritidis, Typhi and Paratyphi which are the major causative agents of either gastroenteritis or typhoid fever. They are responsible for more than 90 million cases and 400 000 deaths each year. The increase in multi-drug resistant strains requires the implementation of prophylactic mucosal vaccines. Besides, the intestinal environment is characterized by a balance between immune tolerance and inflammatory response tightly regulated by secretory immunoglobulins (Ig) A. Mucosal IgA are mainly dimeric, serum IgA monomeric and two IgA isotypes have been described in humans: IgA1 and IgA2. We firstly explored the functions of the different isotypes and isoforms of human IgA. We pointed out a pro-inflammatory role of IgA2 whereas IgA1 rather oriented the immunity towards an anti-inflammatory response. We have also highlighted both the regulation of IgA receptors expression by IgA and an IgA/CD8 cytotoxic T cells axis. We also designed a multivalent vaccine against Salmonella by coupling two antigens – SseB and OmpC – to secretory Ig. We pointed out solid specific humoral and cellular responses against both these antigens coupled to either IgA or IgM after intra-nasal immunization in mucosal but also systemic compartments. We have also demonstrated the possibility to preserve and increase the antigen immunogenicity with a multivalent vaccine. This thesis thus paves the way for new secretory Ig-vectorized mucosal vaccines. In addition, the immune response could be modulated through the chosen isotype or isoform and the differences in immune activation generated by structural changes in IgA could shed some light on their role in mucosal homeostasis
Gyllin, Rebecca, and Carina Pettersson. "Fastighetsvärdering : Fastighetskrisen under 1990-talet kan det upprepas igen?" Thesis, Linköping University, Department of Management and Economics, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-5698.
Повний текст джерелаBakgrund: I början av 1990 – talet drabbades Sverige av en omfattande fastighetskris. Det fanns ett antal faktorer som gemensamt bidrog till att krisen uppstod men även påverkade dess omfattning. Perioden innan krisen hade kännetecknats av lång tid av stigande fastighetspriser och en tro från marknaden om en fortsatt god värdeutveckling. Även bankerna delade synen om en fortsatt värdestegring, vilket bidrog till att krediter beviljades mer utifrån en marknadsvärdering istället för en analys av bolagens återbetalningsförmåga. Införandet av de nya IAS/IFRS reglerna bidrar till en ökad jämförbarhet mellan företag vilket främst har efterfrågats av investerare. Förvaltningsfastighetsbolag kan välja att redovisa enligt ”fair value model” eller ”cost model”. Om bolagen väljer att redovisa enligt ”fair value model” skall fastigheterna i redovisningen värderas till verkligt värde. Det innebär att värdeförändringen kommer att justera årets vinst eller förlust via resultaträkningen vilket påverkar bolagets egna kapital.
Syfte: Att se om vi kan finna att bankerna i sin bedömning av värdet på fastigheter kommer att påverkas av de nya redovisningsreglerna. Vi har även för avsikt att undersöka om dessa redovisningsregler kan bidra till en övervärdering av fastigheter och om det kan leda till en ny spekulationsbubbla.
Genomförande: Vi har genomfört en litteraturstudie som har kompletterats med fem stycken kvalitativa intervjuer.
Uppsatsens huvudsakliga resultat är:Lärdom av den tidigare krisen har gjorts enligt bankerna både hos dem själva och inom fastighetsbranschen. Nya värderingsunderlag används, bankernas bedömningar görs utifrån fastigheternas kassaflöde ibland i kombination med ortsprisanalyser. Fastighetsbolagen använder sig av olika räntesäkringsinstrument för att skydda sig mot kraftig stigande räntor. Att en ny fastighetskris skulle vara aktuell anser bankerna inte vara troligt. Den slutsatsen dras utifrån att de underliggande faktorer som tillsammans bidrog till fastighetskrisens uppkomst ser helt annorlunda ut idag jämfört med tiden innan krisen. Vi delar inte bankerna uppfattning fullt ut då vi anser att det finns en risk att omvärldsfaktorer snabbt kan ändras. Till exempel genom politiska beslut vilket kan bidra till en ny fastighetskris. Att de nya redovisningsreglerna ändå kan få betydelse för värdering av fastigheternas värde är enligt oss att det kan ske en omedveten justering av värderingsunderlaget. Det finns återigen en god likviditet på marknaden som enligt oss kan leda till en förhöjd vilja hos bankerna att öka sina kreditvolymer.
Widell, Therese, and Tobias Åkerberg. "Fåmansföretagsreglerna ändras igen : Med tre fiktiva företag analyseras effekterna." Thesis, Uppsala University, Department of Business Studies, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8621.
Повний текст джерелаReglerna om beskattning av fåmansföretag, de så kallade 3:12 reglerna, är ett omdiskuterat ämne i det svenska näringslivet. Trots den omfattande reformen av 3:12 reglerna som gjordes till år 2006 har den nu sittande regeringen valt att ändra reglerna ytterligare med hänvisning till att det skall bli mer lönsamt att driva företag och att anställa. Syftet med denna uppsats är se över de förändringar som skett inom fåmansföretagsbeskattningen och analysera hur dessa förändringar kan komma att påverka fåmansföretagare. För att analysera de nya reglernas förväntade effekter använder vi oss av tre fiktiva företag av olika storlekar.
Regelförändringarna ger fåmansföretag möjlighet till att göra större utdelningar än tidigare till den förmånligare skattesatsen på 20 %. Förändringarna kommer att ge störst effekt på de mindre och mellanstora fåmansföretagen, dock har inte komplexiteten på reglerna minskat genom förändringarna. Vidare anser vi att risken för att en ägare till ett fåmansföretag skulle lockas genom den nu mer generösa utdelningsmöjligheten till att ta ut för mycket i kapital är minimal. Däremot anser vi att regelförändringarna ger företagen en morot till att anställa eftersom skattelättnader och en högre förmånligare utdelning ger ett incitament för entreprenörer att starta och utveckla företag. Vår slutsats är även att fåmansföretagsägare nu borde ändra sin uppfattning om reglerna.
Strömberg, Erika, and Tone Suslin. "SINNESMARKNADSFÖRING : Känner du igen doften av ett starkt varumärke?" Thesis, Högskolan i Skövde, Institutionen för teknik och samhälle, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-6117.
Повний текст джерелаIs it possible to feel, taste, smell and hear a strong brand? Or are you only able to spot it with your eyes? In this report our main purpose was to answer these questions. The result and conclusion from this study are what you now hold in your hands. We have through interviews with three major retail chains and its store managers tried to get a clearer picture of how they work with the relatively new way to advertise on, through sensory marketing. We have made several observations and formed us a good indication of how each store uses sensory marketing- either conscious or unconscious. As consumer demand for experience grows and as more retailers enter the market, it becomes increasingly important to create a brand that customers always have in their consciousness. The only way to do this is to be the natural first choice. To reach today's discerning consumers in stores, it is important to market its brand. Because this has not seemed to be enough, new ways of marketing has been discovered, what we call sensory marketing. The concept is relatively new in Sweden and aims to create an emotional bond between consumer and brand. By stimulating consumer's five senses, taste, touch, sight, hearing and smell, it contributes to create the type of emotional bond that marketers endeavor to obtain. The findings of this study are based on qualitative approach and to do this we have used two different methods, both interviews with store managers and through observation of the stores itself. This study includes studies of three stores which are all located in the city heart of Katrineholm. These stores, Lindex, KappAhl and Byoung, have all helped to make this study possible. We have in our study concluded that man's five senses seem more significant than was often thought before. To not only rely on the sense of vision that many people seem to do, has also shown to be important when building a brand. By covering as many senses as possible, you can get the customer to associate certain feelings and past experiences with the brand. Hopefully, this also enhances the relationship between customer and brand.
Klingfors, Gunno. "Bach går igen : källkritiska studier i JS Bachs uppförandepraxis /." Göteborg : Göteborgs universitet, 1991. http://catalogue.bnf.fr/ark:/12148/cb36955876f.
Повний текст джерелаSpooner, R. Katharine. "An investigation of the IgA1 protease of Ureaplasma urealyticum." Thesis, University of St Andrews, 1994. http://hdl.handle.net/10023/14302.
Повний текст джерелаWright, Alison Laing. "IGA MEDIATED DEFENSES AGAINST HIV-1." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1201290332.
Повний текст джерелаBéné, Marie-Christine. "Nephropatie a iga et immunite muqueuse." Paris 7, 1991. http://www.theses.fr/1991PA077007.
Повний текст джерелаCarnicer, Cáceres Clara. "Utilidad clínica de biomarcadores de severidad y pronóstico de la nefropatía IgA en el adulto." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/457577.
Повний текст джерелаUrinary levels of molecules related to the activation of complement and to the local inflammatory environment inducing renal injury have been widely studied as potential predictive markers of disease severity and prognosis in IgA nephropathy (IgAN). However, the role of these molecules as potential biomarkers remains poorly defined for several reasons. On one hand, the association between the urinary levels of some of these molecules and their respective mesangial deposits has not been adequately analyzed, and the contribution of molecules involved in the lectin pathway to complement activation in tubular cells is unknown. There are also no studies comparing the predictive ability of interstitial fibrosis among several urinary markers of renal injury progression. In addition, the data available are based on measurements obtained in spot-urine samples, and the accuracy of such measurements to estimate the 24h urine excretion has not been analyzed. Finally, the sources of variation subject to these measures have not been estimated, which are necessary to correctly interpret the results and define the methodological specifications. This thesis provides new data to the existing literature on these molecules through four observational studies performed in cohorts of patients with IgAN. The studies were focused on measurements of mannose binding lectin (MBL), C4d, C5b-9, properdin, interleukin 6 (IL-6), epidermal growth factor (EGF), monocyte chemoattractant protein 1 (MCP-1) and transforming growth factor β1 (TGFβ-1). The ability of urinary levels of complement related proteins to identify the local complement pathways activated in kidney biopsies was assessed, as well as the ability of urinary levels of cytokines and growth factors to predict the amount of interstitial fibrosis. The accuracy of spot-urine EGF measurements to predict the daily EGF excretion was also analyzed. Finally, sources of variation subject to urinary EGF measurements were estimated. This thesis concludes that urinary MBL contributes to the activation of complement by the lectin pathway in tubular cells and is associated with the severity of tubulointerstitial injury, and therefore could be considered as a potential marker of the severity of kidney injury in patients with IgAN. Urinary levels of MBL and C4d might be used in clinical practice as sensitive and specific biomarkers of the presence of their respective mesangial deposits. Results also show that urinary levels of EGF, MCP-1 and IL-6 improve the predictive ability of models including glomerular filtration rate (GFR) and age to estimate kidney interstitial fibrosis. The combination of MCP-1 and EGF levels, or MCP-1 and IL-6 levels, provide similar predictive power and appear to be the most appropriate to be applied in clinical practice. In addition, the spot EGF/creatinine ratio do not provide an adequate prediction of 24h excretion of EGF. In addition, the accuracy of the EGF/creatinine ratio to predict the 24h excretion depends on GFR and on the ensuing degree of interstitial fibrosis. Daily EGF excretion correlates more strongly with fibrosis than EGF/creatinine ratio, and its use is preferred both in studies that aim to analyze the value of EGF excretion as an early prognostic biomarker in individuals with high GFR values, as well as in those designed to estimate the tubular mass from urinary levels of EGF in patients with advanced chronic renal disease. Finally, the results show that in the EGF/creatinine ratio measurements the reference change value (RCV) should be applied to assess a clinically significant change in patients. In addition, different RCVs should be used depending on the degree of interstitial fibrosis and/or GFR.
Sá, Ana Mafalda Neves Costa Silva e. "Hotel management and the generational impact of Millennials and iGen." Master's thesis, Escola Superior de Hotelaria e Turismo do Estoril, 2017. http://hdl.handle.net/10400.26/19722.
Повний текст джерелаA Geração Z, nascida no final do século XX/início do novo milénio, representa um novo grupo de consumidores, conectados online praticamente desde o seu nascimento, sendo comummente designados como iGen. Este novo grupo de potenciais consumidores revela uma nova realidade para diversos sectores. O que poderá ser dito sobre esta futura procura de mercado? Não obstante, outro consumidor já fortemente presente na procura e oferta mercado do Sector Hoteleiro, é o consumidor da Geração Y, também conhecido como Millennial. Como poderá o Mercado Hoteleiro beneficiar com o conhecimento de preferências, comportamentos online, e padrões de consumo de Millennials e iGen? Aplicando um método quantitativo de pesquisa (questionário) às Gerações Y, X e Baby Boomers, e um método qualitativo (focus group) à Geração Y e pais de iGen, a presente pesquisa pretendeu caracterizar Millennials e iGen. Apesar da idade jovem da iGen, é evidente o impacto que a tecnologia tem na sua vida. Comparados com a Geração Y, iGen crescem ligados a diversos dispositivos online, conectados por vídeo, enquanto que a anterior, primeira geração digital, encontra-se em transição para esta nova realidade, valorizando ainda a imagem. Ambas as gerações viajam mais do que os seus pais na sua idade. Se Millennials são mais conscientes do preço do seu alojamento, dispondo de agregadores de preço, as unidades hoteleiras deverão reagir a esta era online e de informação. Conhecendo os seus social media preferenciais, como comunicam, e o seu comportamento de compra de viagem, o Mercado Hoteleiro poderá assim personalizar melhor o seu serviço, aproximando-se de consumidores sustentáveis. Por outro lado, a iGen cresce exposta a Snapchat, YouTube, Instagram, absorta em vídeos, imagens, e influenciadores digitais. Apesar de não terem uma influência direta na decisão de viagem do seu agregado familiar, as referências que criam poderão influenciá-lo indiretamente, cada vez mais, alguns deles inclusive pedindo Wi-Fi no alojamento em férias, que o seu agregado escolha. Assim, o estudo pretendeu coletar comportamentos-chave de Millennials e iGen, posteriormente sugerindo direções futuras para o Mercado Hoteleiro.
Loew, Sebastian [Verfasser]. "Funktionelle Charakterisierung eines rekombinanten IgA2 Antikörpers gegen CD20 / Sebastian Loew." Kiel : Universitätsbibliothek Kiel, 2018. http://d-nb.info/1168229103/34.
Повний текст джерелаBajqinca, Nuhi. ""Vi tar det på ta-igen-tiden" : Aktionsforskning om modersmålsundervisning." Thesis, Högskolan i Borås, Institutionen för Pedagogik, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-19312.
Повний текст джерелаCámara, García Miguel María. "Molecular studies on IgA1 protease and neuraminidase from Streptococcus pneumoniae." Thesis, University of Leicester, 1992. http://hdl.handle.net/2381/35309.
Повний текст джерелаNilsson, Frida. "Att finna sig själv igen efter hörselförbättring med Cochlea implantat." Thesis, Malmö högskola, Fakulteten för hälsa och samhälle (HS), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24411.
Повний текст джерелаThemed interviews have been conducted to explore and understand whether the deaf adult people who have undergone a CI-operation have observed any changes in their identity experiences after their hearing has improved. The qualitative study is based on the individual's own experiences of the cochlear implant (CI). The number of people having a cochlear implant are increasing. The study highlights the personal stories and experiences of the CI bringing back their hearing ability. These stories are very important because they provides us with knowledge about the support these people needs through their rehabilitation, a kind of knowledge that is still largely lacking. The results showed that personal identity is the same but it may be the social identity, which can be problematic in some aspects to write a role that does not confirm to their own self-image.
Smerud, Hilde Kloster. "IgA Nephropathy – Mucosal Immunity and Treatment Options." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-168631.
Повний текст джерелаMenahem, Solomon. "Apoptosis in the progression of IGA nephropathy." Monash University, Faculty of Medicine, Nursing and Health Sciences, 2003. http://arrow.monash.edu.au/hdl/1959.1/9449.
Повний текст джерелаSanderson, Christopher Mark. "Transport of IgA in rat salivary glands." Thesis, University of Surrey, 1986. http://epubs.surrey.ac.uk/847984/.
Повний текст джерелаMole, Claire. "Caractéristiques immunochimiques des IGA des secrétions humaines." Nancy 1, 1991. http://www.theses.fr/1991NAN10457.
Повний текст джерелаSITBON, GUILLER JULIETTE. "A propos d'un deficit familial en iga." Nantes, 1991. http://www.theses.fr/1991NANT025M.
Повний текст джерелаMascart, Françoise. "Contribution à l'étude de la réponse de type IgA chez l'homme: signification de la présence des anticorps IgA polymériques." Doctoral thesis, Universite Libre de Bruxelles, 1990. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/213200.
Повний текст джерелаJonsson, Camilla, and Cecilia Ohlén. "Att bli sig själv igen : Psykosocial hälsa och livskvalitet efter bröstrekonstruktion." Thesis, Uppsala University, Department of Public Health and Caring Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-112528.
Повний текст джерелаWilhelmsson, Oskar, and Victor Wikén. "Genomförbarhetsstudie av att känna igen två tankemönster i följd med EEG." Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-188798.
Повний текст джерелаThis study implements a Brain-Computer-Interface using the EEG-instrument MindWave Mobile Headset. We studied the feasibility of performing four operations using thought patterns. Four test subjects participated in the study. Their task was to think in two subsequent thought patterns that resulted in an operation. The EEG-signal was pre-processed in such a way that a pattern recognition algorithm (k-NN) more easily could recognize two thought patterns in the signal. This study has to our knowledge not been done before and thus aims to fill this lack of knowledge in the scientific community. User groups that have an interest in filling this gap are, amongst others; disabled people, gamers, and Virtual Reality users. We created a model that modeled the best possible outcome of the method used in this study. Conclusions drawn from the result can not be used to fully answer the problem statement, since it would be to post hoc-theorize. However, three out of four operations were possible to perform in the model, with an indication that the fourth also was possible to perform. These results indicate that there are grounds to continue this study. The proposed continued study should include new measurements that are tested by the model to determine if it is feasible to distinguish all four operations.
Andersson, Mikael. "På spaning efter den tid som flytt (igen) : En heterogen iscensättning." Thesis, KTH, Arkitektur, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-150400.
Повний текст джерелаGrängesberg, a town in Bergslagen build up around a large-scale iron mine were one of the most important places for the Swedish economy during the turn of the 20th century. Today the mine is closed down and all that is left is an enormous crater and huge industrial structures. My project is an investigation through design methods to try to understand the complexity of what Grängesberg have been and what it is today.