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Добірка наукової літератури з теми "Hyperthermia cancer magnetic field"

Автор: Grafiati

Опубліковано: 11 березня 2023

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Статті в журналах з теми "Hyperthermia cancer magnetic field"

1

Choi, D. S., J. Park, S. Kim, D. H. Gracias, M. K. Cho, Y. K. Kim, A. Fung, et al. "Hyperthermia with Magnetic Nanowires for Inactivating Living Cells." Journal of Nanoscience and Nanotechnology 8, no. 5 (May 1, 2008): 2323–27. http://dx.doi.org/10.1166/jnn.2008.273.

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Анотація:

We describe a method to induce hyperthermia in cells, in-vitro, by remotely heating Ni nanowires (NWs) with radio frequency (RF) electromagnetic fields. Ni NWs were internalized by human embryonic kidney cells (HEK-293). Only cells proximal to NWs or with internalized NWs changed shape on exposure to RF fields indicative of cell death. The cell death occurs as a result of hyperthermia, since the RF field remotely heats the NWs as a result of magnetic hysteresis. This is the first demonstration of hyperthermia induced by NWs; since the NWs have anisotropic and strong magnetic moments, our experiments suggest the possibility of performing hyperthermia at lower field strengths in order to minimize damage to untargeted cells in applications such as the treatment of cancer.

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2

Mostafa Yusefi, Kamyar Shameli, and Siti Nur Amalina Mohamad Sukri. "Magnetic Nanoparticles In Hyperthermia Therapy: A Mini-Review." Journal of Research in Nanoscience and Nanotechnology 2, no. 1 (May 13, 2021): 51–60. http://dx.doi.org/10.37934/jrnn.2.1.5160.

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Анотація:

The activation of MNPs for hyperthermia therapy via an external alternating magnetic field is an interesting method in targeted cancer therapy. This mini-review explains new developments and implications of magnetic nanofluids mediated magnetic hyperthermia for their potential use in future clinical settings. The external alternating magnetic field generates heat in the tumor area to eliminate cancer cells. Depending on the tumor type and targeted area, several kinds of MNPs with different coating agents of various morphology and surface charge have been developed. The tunable physiochemical characteristics of MNPs enhance their heating capability. In addition, heating efficiency is strongly associated with the amount of the applied magnetic field and frequency. The great efforts have offered promising preclinical trials of magnetic hyperthermia via MNPs as a smart nanoagent. MNPs are very appropriate to be considered as a heating source in MHT and prospective research in this field will lead to tackle the problems from chemotherapy and introduce promising therapeutic techniques and nanodrug formulations for remotely controlled drug release and anticancer effects. This mini-review aims to pinpoint synthesis and structural analysis of various magnetic nanoparticles examined for magnetic hyperthermia therapy and controlled drug release in cancer treatment.

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3

GIUSTINI, ANDREW J., ALICIA A. PETRYK, SHIRAZ M. CASSIM, JENNIFER A. TATE, IAN BAKER, and P. JACK HOOPES. "MAGNETIC NANOPARTICLE HYPERTHERMIA IN CANCER TREATMENT." Nano LIFE 01, no. 01n02 (March 2010): 17–32. http://dx.doi.org/10.1142/s1793984410000067.

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Анотація:

The activation of magnetic nanoparticles (mNPs) by an alternating magnetic field (AMF) is currently being explored as technique for targeted therapeutic heating of tumors. Various types of superparamagnetic and ferromagnetic particles, with different coatings and targeting agents, allow for tumor site and type specificity. Magnetic nanoparticle hyperthermia is also being studied as an adjuvant to conventional chemotherapy and radiation therapy. This review provides an introduction to some of the relevant biology and materials science involved in the technical development and current and future use of mNP hyperthermia as clinical cancer therapy.

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4

Nemkov, V., R. Ruffini, R. Goldstein, J. Jackowski, T. L. DeWeese, and R. Ivkov. "Magnetic field generating inductor for cancer hyperthermia research." COMPEL - The international journal for computation and mathematics in electrical and electronic engineering 30, no. 5 (September 13, 2011): 1626–36. http://dx.doi.org/10.1108/03321641111152784.

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5

Kim, D. H., Se Ho Lee, Kyoung Nam Kim, Kwang Mahn Kim, I. B. Shim, and Yong Keun Lee. "In Vitro and In Vivo Characterization of Various Ferrites for Hyperthermia in Cancer-Treatment." Key Engineering Materials 284-286 (April 2005): 827–30. http://dx.doi.org/10.4028/www.scientific.net/kem.284-286.827.

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Анотація:

Ceramic ferrites can be used to cancer-treatment. Heating of certain organs or tissue up to temperature between 42oC and 45oC preferentially for cancer therapy is called hyperthermia. We synthesized ferrites with various compositions in the system Co1-xNixFe2O4 as hyperthermic thermoseed in cancer-treatment and evaluated their effects on the necrosis of cancer cells under alternating magnetic field in vivo as well as in vitro. When a CoFe2O4 was placed into 0.2 ml distilled water, the greatest temperature change in this study, Δ T=29.3oC, was observed. More than half of the carcinoma cells were dead after exposure to alternating magnetic field using CoFe2O4, while normal cells were survived more than 60%. The injection of this ferrite particles into the tumor bearing mice was able to suppress the number and volume of tumors. CoFe2O4 is expected the useful hyperthermic thermoseed in cancer-treatment because it exhibited the greatest necrosis of carcinoma cells in vitro and in vivo.

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6

Palzer, Julian, Lea Eckstein, Ioana Slabu, Oliver Reisen, Ulf P. Neumann, and Anjali A. Roeth. "Iron Oxide Nanoparticle-Based Hyperthermia as a Treatment Option in Various Gastrointestinal Malignancies." Nanomaterials 11, no. 11 (November 10, 2021): 3013. http://dx.doi.org/10.3390/nano11113013.

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Анотація:

Iron oxide nanoparticle-based hyperthermia is an emerging field in cancer treatment. The hyperthermia is primarily achieved by two differing methods: magnetic fluid hyperthermia and photothermal therapy. In magnetic fluid hyperthermia, the iron oxide nanoparticles are heated by an alternating magnetic field through Brownian and Néel relaxation. In photothermal therapy, the hyperthermia is mainly generated by absorption of light, thereby converting electromagnetic waves into thermal energy. By use of iron oxide nanoparticles, this effect can be enhanced. Both methods are promising tools in cancer treatment and are, therefore, also explored for gastrointestinal malignancies. Here, we provide an extensive literature research on both therapy options for the most common gastrointestinal malignancies (esophageal, gastric and colorectal cancer, colorectal liver metastases, hepatocellular carcinoma, cholangiocellular carcinoma and pancreatic cancer). As many of these rank in the top ten of cancer-related deaths, novel treatment strategies are urgently needed. This review describes the efforts undertaken in vitro and in vivo.

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7

Fatima, Hira, Tawatchai Charinpanitkul, and Kyo-Seon Kim. "Fundamentals to Apply Magnetic Nanoparticles for Hyperthermia Therapy." Nanomaterials 11, no. 5 (May 1, 2021): 1203. http://dx.doi.org/10.3390/nano11051203.

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Анотація:

The activation of magnetic nanoparticles in hyperthermia treatment by an external alternating magnetic field is a promising technique for targeted cancer therapy. The external alternating magnetic field generates heat in the tumor area, which is utilized to kill cancerous cells. Depending on the tumor type and site to be targeted, various types of magnetic nanoparticles, with variable coating materials of different shape and surface charge, have been developed. The tunable physical and chemical properties of magnetic nanoparticles enhance their heating efficiency. Moreover, heating efficiency is directly related with the product values of the applied magnetic field and frequency. Protein corona formation is another important parameter affecting the heating efficiency of MNPs in magnetic hyperthermia. This review provides the basics of magnetic hyperthermia, mechanisms of heat losses, thermal doses for hyperthermia therapy, and strategies to improve heating efficiency. The purpose of this review is to build a bridge between the synthesis/coating of magnetic nanoparticles and their practical application in magnetic hyperthermia.

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8

Dinh, Quang Thanh, Van Tuan Dinh, Hoai Nam Nguyen, Tien Anh Nguyen, Xuan Truong Nguyen, Luong Lam Nguyen, Thi Mai Thanh Dinh, Hong Nam Pham, and Van Quynh Nguyen. "Synthesis of magneto-plasmonic hybrid material for cancer hyperthermia." Journal of Military Science and Technology, no. 81 (August 26, 2022): 128–37. http://dx.doi.org/10.54939/1859-1043.j.mst.81.2022.128-137.

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Анотація:

Magnetic nanoparticle CoFe2O4-based hyperthermia is a promising non-invasive approach for cancer therapy. However, CoFe2O4 nanoparticles (NPs) have a low heat transfer efficiency, which limits their practical clinical applications. Hence, it is necessary to investigate the higher-performance magnetic NPs-based hybrid nanostructures to enhance their magnetic hyperthermia efficiency. This work presents a facile in situ approach for synthesizing cobalt ferrite (CoFe2O4) silver (Ag) hybrid NPs as optical-magnetic hyperthermia heat mediators. The prepared cobalt ferrite silver hybrid NPs exhibit a higher heat generation than that of individual Ag or CoFe2O4 NPs under simultaneous exposure to an alternating current magnetic field and laser source. The obtained results confirm that the hybridization of CoFe2O4 and Ag NPs could significantly enhance the hyperthermia efficiency of the prepared NPs. Therefore, the CoFe2O4-Ag hybrid NPs are considered as potential candidates for a high-performance hyperthermia mediator based on a simple and effective synthesis approach.

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9

Mamiya, Hiroaki, Yoshihiko Takeda, Takashi Naka, Naoki Kawazoe, Guoping Chen, and Balachandran Jeyadevan. "Practical Solution for Effective Whole-Body Magnetic Fluid Hyperthermia Treatment." Journal of Nanomaterials 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/1047697.

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Анотація:

Magnetic fluid hyperthermia therapy is considered as a promising treatment for cancers including unidentifiable metastatic cancers that are scattered across the whole body. However, a recent study on heat transfer simulated on a human body model showed a serious side effect: occurrences of hot spots in normal tissues due to eddy current loss induced by variation in the irradiated magnetic field. The indicated allowable upper limit of field amplitude Hac for constant irradiation over the entire human body corresponded to approximately 100 Oe at a frequency f of 25 kHz. The limit corresponds to the value Hacf of 2.5 × 106 Oe·s−1 and is significantly lower than the conventionally accepted criteria of 6 × 107 Oe·s−1. The present study involved evaluating maximum performance of conventional magnetic fluid hyperthermia cancer therapy below the afore-mentioned limit, and this was followed by discussing alternative methods not bound by standard frameworks by considering steady heat flow from equilibrium responses of stable nanoparticles. Consequently, the clarified potentials of quasi-stable core-shell nanoparticles, dynamic alignment of easy axes, and short pulse irradiation indicate that the whole-body magnetic fluid hyperthermia treatment is still a possible candidate for future cancer therapy.

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10

Shivanna, Anilkumar Thaghalli, Banendu Sunder Dash, and Jyh-Ping Chen. "Functionalized Magnetic Nanoparticles for Alternating Magnetic Field- or Near Infrared Light-Induced Cancer Therapies." Micromachines 13, no. 8 (August 8, 2022): 1279. http://dx.doi.org/10.3390/mi13081279.

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Анотація:

The multi-faceted nature of functionalized magnetic nanoparticles (fMNPs) is well-suited for cancer therapy. These nanocomposites can also provide a multimodal platform for targeted cancer therapy due to their unique magnetic guidance characteristics. When induced by an alternating magnetic field (AMF), fMNPs can convert the magnetostatic energy to heat for magnetic hyperthermia (MHT), as well as for controlled drug release. Furthermore, with the ability to convert near-infrared (NIR) light energy to heat energy, fMNPs have attracted interest for photothermal therapy (PTT). Other than MHT and PTT, fMNPs also have a place in combination cancer therapies, such as chemo-MHT, chemo-PTT, and chemo-PTT–photodynamic therapy, among others, due to their versatile properties. Thus, this review presents multifunctional nanocomposites based on fMNPs for cancer therapies, induced by an AMF or NIR light. We will first discuss the different fMNPs induced with an AMF for cancer MHT and chemo-MHT. Secondly, we will discuss fMNPs irradiated with NIR lasers for cancer PTT and chemo-PTT. Finally, fMNPs used for dual-mode AMF + NIR-laser-induced magneto-photo-hyperthermia (MPHT) will be discussed.

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Більше джерел

Дисертації з теми "Hyperthermia cancer magnetic field"

1

Lukawska, Anna Beata. "THERMAL PROPERTIES OF MAGNETIC NANOPARTICLES IN EXTERNAL AC MAGNETIC FIELD." Wright State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=wright1401441820.

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2

Hallali, Nicolas. "Utilisation de nanoparticules magnétiques dans les traitements anti-tumoraux : Au-delà de l'hyperthermie magnétique." Thesis, Toulouse, INSA, 2016. http://www.theses.fr/2016ISAT0025/document.

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Анотація:

Deux approches potentiellement anti-tumorales, employant des nanoparticules magnétiques (NPMs) et des champs magnétiques oscillants, furent étudiées. La première, l’hyperthermie magnétique, utilise l’échauffement de NPMs au contact des cellules tumorales provoqué par un champ magnétique alternatif haute-fréquence. Durant cette thèse, il fut démontré que les forces magnéto-mécaniques induites par les inhomogénéités de champ magnétique pendant un essai d’hyperthermie magnétique n’avaient aucune influence sur la viabilité cellulaire. Egalement, des mesures magnétiques, d’XPS, et de puissance de chauffe de NPMs de fer enrobées d’une coquille de silice amorphe furent effectuées et analysées. Il fut observé que cette coquille permettait de préserver les propriétés magnétiques des NPMs suite à l’exposition à un environnement aqueux. La deuxième approche anti-tumorale utilise des NPMs soumises à un champ magnétique basse-fréquence, induisant une stimulation mécanique des cellules tumorales. Une étude théorique complète de l’influence du champ magnétique, de l’agitation thermique et des interactions magnétiques sur la force magnéto-mécanique exercée par des NPMs, fut effectuée. Elle démontra notamment que cette force augmente de manière drastique pour une assemblée de NPMs lorsque la rotation du champ magnétique induit une rupture de symétrie dans l’évolution temporelle du couple magnéto-mécanique. Expérimentalement, il fut développé différents prototypes de génération de champ magnétique tournant à basse fréquence. Des tests in vitro furent réalisés en utilisant des NPMs enrobées par une matrice de phosphatidylcholine, leur permettant d’être solidaires des membranes cellulaires. Suite à la rotation d’un champ magnétique de 40 ou 380 mT, à 10 Hz, il fut observé une réduction de la survie cellulaire
Two anti-tumor treatments based on magnetic nanoparticles (MNPs) and oscillating magnetic field were studied. The first one, magnetic hyperthermia, uses the heat released by MNPs in contact with tumor cells under a high frequency alternating magnetic field. We have shown that the forces induced by magnetic field inhomogeneity during magnetic hyperthermia essay no influence on cellular viability. Moreover, magnetic measurements, XPS characterization and heating power evaluation of iron MNPs coated by amorphous silica shell were carried out. It was observed that this shell is able to preserve the MNP magnetic properties submitted to an aqueous environment. The second anti-tumor treatment combines MNPs and low-frequency magnetic field, inducing mechanical stress to tumor cells. A complete theoretical study on the influence of magnetic field, thermal agitation and magnetic interaction on the magneto-mechanical forces generated by the MNPs was carried out. It was demonstrated that for a MNP assembly this force increases dramatically when the rotation of the magnetic field induces a break of time reversal symmetry on the magneto-mechanical torque. Experimentally, several devices generating low frequency rotating magnetic fields were developed. Using these devices, in-vitro essays were also achieved using phosphatidylcholine coated MNPs, which bind to cellular membranes. An application of a 40 or 380 mT magnetic field rotating at 10 Hz reduced cell survival rate

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3

Nemati, Porshokouh Zohreh. "Novel Magnetic Nanostructures for Enhanced Magnetic Hyperthermia Cancer Therapy." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6548.

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Анотація:

In this dissertation, I present the results of a systematic study on novel multifunctional nanostructure systems for magnetic hyperthermia applications. All the samples have been synthesized, structurally/magnetically characterized, and tested for magnetic hyperthermia treatment at the Functional Materials Laboratory of the University South Florida. This work includes studies on four different systems: (i) Core/shell Fe/γ-Fe2O3 nanoparticles; (ii) Spherical and cubic exchange coupled FeO/Fe3O4 nanoparticles; (iii) Fe3O4 nano-octopods with different sizes; (iv) High aspect ratio FeCo nanowires and Fe3O4 nanorods. In particular, we demonstrated the enhancement of the heating efficiency of these nanostructures by creating monodisperse and highly crystalline nanoparticles, and tuning their magnetic properties, mainly their saturation magnetization (MS) and effective anisotropy, in controlled ways. In addition, we studied the influence of other parameters, such as the size and concentration of the nanoparticles, the magnitude of the applied AC magnetic field, or different media (agar vs. water), on the final heating efficiency of these nanoparticles. For the core/shell Fe/γ-Fe2O3 nanoparticles, a modest heating efficiency has been obtained, resulting mainly from the strong reduction in MS caused by the shrinkage of the core with time. However, for sizes above 14 nm, the shrinkage process is much slower and the obtained heating efficiency is better than the one exhibited by conventional solid nanoparticles of the same size. In the case of the exchange-coupled FeO/Fe3O4 nanoparticles, we successfully created two sets of comparable particles: spheres with 1.5 times larger MS than the cubes, and cubes with 1.5 times larger effective anisotropy than the spheres, while keeping the other parameters the same. Our results show that increasing the effective anisotropy of the nanoparticles gives rise to a greater heating efficiency than increasing their MS. The Fe3O4 nano-octopods, with enhanced surface anisotropy, present better heating efficiency than their spherical and cubic nanoparticles, especially in the high field region, and we have shown that by tuning their size and the effective anisotropy, we can optimize their heating response to the applied AC magnetic field. For magnetic fields, smaller than 300−400 Oe we found that the smallest nano-octopods give the best heating efficiency. Yet if we increase the AC field value, the bigger octopods show an increased heating efficiency and become more effective. Finally, the FeCo nanowires and Fe3O4 nanorods exhibit enhanced heating efficiency with increasing aspect ratio when aligned in the direction of the applied AC magnetic field, due to the combined effect of shape anisotropy and dipolar interactions. Of all the studied systems, these 1D high aspect ratio nanostructures have displayed the highest heating rates. All of these findings point toward an important fact that tuning the structural and magnetic parameters in general, and the effective anisotropy in particular, of the nanoparticles is a very promising approach for improving the heating efficiency of magnetic nanostructures for enhanced hyperthermia.

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4

Patel, Anil Pravin. "Cancer hyperthermia using gold and magnetic nanoparticles." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8124/.

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Анотація:

An estimated 12 million people worldwide are diagnosed with cancer every year, with around 17 million cancer-related deaths per year predicted by 2030 (Thun et al. 2010). Contemporary clinical treatments include surgery, chemotherapy and radiotherapy, however all vary in success and exhibit unpleasant side effects. Localised tumour hyperthermia is a moderately new cancer treatment envisaged by researchers, which exploits exclusive tumour vulnerabilities to specific temperature profiles (42-45°C) leading to cancer cell apoptosis, whilst normal tissue cells are relatively unaffected. Hyperthermia is therefore proposed as an alternative potential therapy for cancer, by delivering localised treatment to cancer cells, without the severe side effects associated with traditional therapies. This project aimed to investigate potential hyperthermic treatment of cancer cells in vitro by adopting nanomedicine principles. Inorganic nanoparticles, such as gold or iron oxide, are both capable of generating heat when appropriately stimulated, therefore both have been suggested as candidates for inducing localised tumour heating following their internalisation into cells. In this project, both gold (GNPs) and magnetic (mNPs) were individually assessed for their potential to deliver toxic thermal energy to bone cancer cells (MG63) and breast cancer cells (MCF-7). Studies were carried out both in standard 2D monolayer and in 3D tumour spheroids. When considering use in vivo, it is essential that both GNPs and mNPs are biocompatible, therefore initial studies characterised the cell viability and metabolic activity following incubation with the NPs. The NP internalisation was subsequently verified, prior to hyperthermic studies. Following hyperthermic treatment, both GNPs and mNPs were confirmed as inducing cancer cell death. Further studies were carried out using the GNPs, to identify the cell death pathways activated, where mitochondrial stress was evident following 2D culture tests. Gene and protein expression analysis indicated that cell death occurred predominantly via several apoptotic pathways, through increased fold expression changes in apoptotic markers. Interestingly, cell protective mechanisms were simultaneously switched on, as cells were also observed to exhibit thermotolerance with a number of heat shock proteins (Hsps) being substantially increased during hyperthermic treatments.

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5

Kozissnik, B. "Antibody targeted magnetic nanoparticle hyperthermia for cancer therapy." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1415747/.

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Анотація:

Superparamagnetic iron oxide nanoparticles (SPION) are used clinically to improve the sensitivity of magnetic resonance imaging (MRI). A less exploited property of SPION is their ability to generate heat when subjected to an alternating magnetic field, a process called magnetic alternating current hyperthermia (MACH). Hyperthermia has been shown to be a cancer effective treatment modality in the clinic when given together with radio/chemotherapy. However, delivery of sufficient heat to damage tumours without harming healthy tissue remains challenging. The central hypothesis for this thesis is that MACH activated SPION can be used to generate hyperthermia in situ and therefore will have potential to achieve localised hyperthermic cancer treatments. The aim of the thesis was to evaluate the potential of SPION to deliver localised hyperthermia by: (1) Characterization and comparison of SPION to select a lead candidate for clinical application. (2) Developing conjugation methods to confer SPION with cancer-binding properties by attachment of single chain Fv antibodies (scFv). (3) Evaluating the localisation and heating potential in vivo. SPION were characterized with regard to their hydrodynamic diameter, core size, magnetic properties, atomic iron content and heating potential for hyperthermia application. Different chemistries were evaluated to functionalize the most promising candidate using shMFEm, an scFv targeting the carcinoembryonic antigen (CEA). A CEA-non-binding scFv variant, shNFEm, was used as a negative control. Functionality of the scFv-SPIONs was assessed using quartz crystal microbalance. In vivo heating potential of the SPION was tested in a xenograft tumour model in vivo, using bespoke MACH apparatus. The results established Ferucarbotran (FX), unformulated Resovist®, an MRI contrast agent, as the most suitable candidate for hyperthermia application. Cyanogen bromide chemistry was selected to functionalise Ferucarbotran with the scFvs shMFEm. The FX-scFv conjugates were purified and analysed. Functionality was confirmed by quartz crystal microbalance, enabling the first visualisation of the interaction between a SPION-scFv conjugate and cognate antigen in real-time. The in vivo assessment of Ferucarbotran and the FX-scFv conjugates confirmed the in vitro heating potential of Ferucarbotran. In vivo analysis of heating showed that localised hyperthermia was achievable with intratumoral injection followed by MACH. Histological analysis of the tumours revealed an uneven distribution of particles within the tumours and an accumulation of the particles within the surrounding stroma indicating the future work should include study of innovative tumour delivery methods. These results support the hypothesis of a therapeutic potential for targeted magnetic nanoparticle hyperthermia and indicates the challenges that have be addressed to enable clinical application of this treatment modality.

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6

Petryk, Alicia Ailie. "Magnetic nanoparticle hyperthermia as an adjuvant cancer therapy with chemotherapy." Thesis, Dartmouth College, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3634608.

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Анотація:

Magnetic nanoparticle hyperthermia (mNPH) is an emerging cancer therapy which has shown to be most effective when applied in the adjuvant setting with chemotherapy, radiation or surgery. Although mNPH employs heat as a primary therapeutic modality, conventional heat may not be the only cytotoxic effect. As such, my studies have focused on the mechanism and use of mNPH alone and in conjunction with cisplatinum chemotherapy in murine breast cancer cells and a related in vivo model. MNPH was compared to conventional microwave tumor heating, with results suggesting that mNPH (mNP directly injected into the tumor and immediately activated) and 915 MHz microwave hyperthermia, at the same thermal dose, result in similar tumor regrowth delay kinetics. However, mNPH shows significantly less peri-tumor normal tissue damage. MNPH combined with cisplatinum also demonstrated significant improvements in regrowth delay over either modality applied as a monotherapy. Additional studies demonstrated that a relatively short tumor incubation time prior to AMF exposure (less than 10 minutes) as compared to a 4-hour incubation time, resulted in faster heating rates, but similar regrowth delays when treated to the same thermal dose. The reduction of heating rate correlated well with the observed reduction in mNP concentration in the tumor observed with 4 hour incubation. The ability to effectively deliver cytotoxic mNPs to metastatic tumors is the hope and goal of systemic mNP therapy. However, delivering relevant levels of mNP is proving to be a formidable challenge. To address this issue, I assessed the ability of cisplatinum to simultaneously treat a tumor and improve the uptake of systemically delivered mNPs. Following a cisplatinum pretreatment, systemic mNPs uptake was increased by 3.1 X, in implanted murine breast tumors. Additional in vitro studies showed the necessity of a specific mNP/ Fe architecture and spatial relation for heat-based cytotoxicity in cultured cells.

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7

Holladay, Robert Tyler. "Incorporating Magnetic Nanoparticle Aggregation Effects into Heat Generation and Temperature Profiles for Magnetic Hyperthermia Cancer Treatments." Thesis, Virginia Tech, 2016. http://hdl.handle.net/10919/64507.

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Анотація:

In treating cancer, a primary consideration is the target specificity of the treatment. This is a measure of the treatment dose that the cancerous (target) tissue receives compared to the dose that healthy tissue receives. Nanoparticle (NP) based treatments offer many advantages for target specificity compared to other forms of treatment due to their ability to selectively target tumors. One benefit of using magnetic NPs is their ability to release heat, which can both sensitize tumors to other forms of treatment as well as damage the tumor. The work here aims to incorporate a broad range of relevant physics into a comprehensive model. NP aggregation is known to be a large source of uncertainty in these treatments, thus a framework has been developed that can incorporate the effects of aggregation on NP diffusion, NP heat release, temperature rise, and overall thermal damage. To quanitify thermal damage in both healthy tissue and tumor tissue, the Cumulative Equivalent Minutes at 43 textcelsius~model is used. The Pennes bioheat equation is used as the governing equation for the temperature rise and included in it is a source heating term due to the NPs. NP diffusion and aggregation are simulated via a random walk process, with a probability of aggregation determining if nearest neighbor particles aggregate at each time step. Additionally, models are developed that attempt to incorporate aggregation effects into NP heat dissipation, though each proves to only be accurate when there is little aggregation occurring. In this work, verification analyses are done for each of the above areas and, at minimum, qualitatively accurate results have been achieved. Verification results of this work show that aggregation can be neglected at concentrations on the order of $100~nM$ or less. This however only serves as a rough estimation and further work is needed to gain a better quantitative understanding of the effects of NP concentration on aggregation. Using this concentration as a limitation, results are presented for a variety of tumor sizes and concentration distributions. Because this work incorporates a variety of physics and numerical methods into a single encompassing model, depth and physical accuracy in each area (bio-heat transfer, diffusion via random walk, NP energy dissipation, and aggregation) have been somewhat limited. This does however provide a framework in which each of the above areas can be further developed and their effects examined in the overall course of treatment.
Master of Science

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8

Andersson, Mikael. "Modeling and characterization of magnetic nanoparticles intended for cancer treatment." Thesis, Uppsala universitet, Fasta tillståndets fysik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-199055.

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Cancer is one of the challenges for today's medicine and therefore a great deal of effort is being put into improving known methods of treatment and developing new ones. A new method that has been proposed is magnetic hyperthermia where magnetic nanoparticles linked to the tumor dissipate heat when subjected to an alternating magnetic field and will thus increase the temperature of the tumor. This method makes the tumor more susceptible to radiation therapy and chemotherapy, or can be used to elevate the temperature of the tumor cells to cause cell death. The particles proposed for this are single core and often have a size in the range of 10 nm to 50 nm. To achieve an effective treatment the particles should have a narrow size distribution and the proper size. In this work, a theoretical model for predicting the heating power generated by magnetic nanoparticles was evaluated. The model was compared with experimental results for magnetite particles of size 15 nm to 35 nm dissolved in water. The properties of the particles were characterized, including measurements of the magnetic saturation, the effective anisotropy constant, average size and size distribution. To evaluate the results from the model the AC susceptibility and heating power were experimentally determined. The model is a two-step model. First the out-of-phase component of the AC susceptibility as a function of frequency is calculated. Then this result is used to calculate the heating power. The model gives a correct prediction of the shape of the out-of-phase component of the susceptibility but overestimates its magnitude. Using the experimentally determined out-of-phase component of the susceptibility, the model estimation of the heating power compares quite well with the measured values.

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Kallumadil, M. "Towards a complete magnetic hyperthermia technology as a novel cancer treatment system." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1149633/.

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The subject of this thesis explores the development of magnetic hyperthermia technology at the preclinical stage. Magnetic hyperthermia uses magnetic nanoparticles as functionalisable agents, targeted to cancer sites. They can then be non-invasively activated by alternating magnetic fields to deliver lethal doses of heat to the cancer cells with minimal damage to healthy tissue. This work concentrates on several complex aspects concealed within the conceptual simplicity of magnetic hyperthermia. One key aspect lies in the design of the alternating magnetic field generator. Here, a novel device, the MACH system, that exceeds currently available AC magnetic field generators in performance, form factor and versatility is described and evaluated. Electronic characteristics for 5 different configurations, ranging from a solenoidal to a flat applicator, are presented. Furthermore, magnetic field distributions in and around the applicator coil were modeled for all real configurations and two hypothetical models. These models revealed that in certain configurations high magnetic field gradients exist, prompting careful positioning of samples in real experiments. Sixteen commercially available iron-oxide nanoparticles with potential as hyperthermia candidates were characterised using photon correlation spectroscopy, atomic emission spectroscopy, asymmetric field-flow fractionation, spectrophotometric iron trace analysis, calorimetric analysis and magnetometry. To compare the heating rates of nanoparticle samples, a new design rule parameter, the intrinsic loss parameter (ILP), was introduced to replace the status quo, the equipment-dependent specific absorption rate (SAR). The results highlight a magnetic crystal size dependence with ILP, and also imply that some commercial samples are approaching the best achievable results. Finally, the commercial potential of the MACH system is evaluated in light of new applications that exploit its unique, distinguishing features. Hyperthermia cancer treatment was concluded to have the greatest potential on the long run, with the adhesives and thermoset polymer industry being lucrative short-term targets.

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UEDA, MINORU, MASAAKI MATSUI, TATSUYA KOBAYASHI, KENJI MITSUDO, YASUSHI HAYASHI, and IWAI TOHNAI. "THERMOCHEMOTHERAPY FOR CANCER OF THE TONGUE USING MAGNETIC INDUCTION HYPERTHERMIA (IMPLANT HEATING SYSTEM : IHS)." Nagoya University School of Medicine, 1996. http://hdl.handle.net/2237/16101.

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Книги з теми "Hyperthermia cancer magnetic field"

1

Suleman, Muhammad. In Silico Approach Towards Magnetic Fluid Hyperthermia of Cancer Treatment: Modeling and Simulation. Elsevier Science & Technology, 2023.

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Suleman, Muhammad. In Silico Approach Towards Magnetic Fluid Hyperthermia of Cancer Treatment: Modeling and Simulation. Elsevier Science & Technology Books, 2023.

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Close, Frank. 8. Applied nuclear physics. Oxford University Press, 2015. http://dx.doi.org/10.1093/actrade/9780198718635.003.0008.

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Nuclear physics is a rich and active field. The large amounts of latent energy within the nuclei of atoms can be liberated in nuclear reactors. Together with nuclear weapons, this is the most familiar application of nuclear physics, but ‘Applied nuclear physics’ provides a summary of other applications to industry, medical science, and human health. The phenomenon of natural radioactivity provides beams of particles, which may be used to initiate other nuclear reactions, or to attack tumours in cancer treatment. Forensics via induced radioactivity, nuclear magnetic resonance imaging (NMRI), and positron emission tomography (PET) scans are also described.

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Частини книг з теми "Hyperthermia cancer magnetic field"

1

Balasubramanian, Sivakumar, and Allison J. Cowin. "Magnetic Nanoparticles for Hyperthermia against Cancer." In Bionanotechnology in Cancer, 337–72. New York: Jenny Stanford Publishing, 2022. http://dx.doi.org/10.1201/9780429422911-11.

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Asín, Laura, Grazyna Stepien, María Moros, Raluca Maria Fratila, and Jesús Martínez de la Fuente. "Magnetic Nanoparticles for Cancer Treatment Using Magnetic Hyperthermia." In Clinical Applications of Magnetic Nanoparticles, 305–18. Boca Raton : Taylor & Francis, 2018.: CRC Press, 2018. http://dx.doi.org/10.1201/9781315168258-16.

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Chaudhary, Richa, and Varun Chaudhary. "Magnetic Nanomaterials for Hyperthermia and Bioimaging." In Nanomaterials for Cancer Detection Using Imaging Techniques and Their Clinical Applications, 91–114. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-09636-5_4.

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4

Hand, J. W., and R. H. Johnson. "Field Penetration from Electromagnetic Applicators for Localized Hyperthermia." In Recent Results in Cancer Research, 7–17. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-82530-9_2.

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5

Weisser, M., and P. Kneschaurek. "Advanced Technique in Localized Current Field Hyperthermia." In Application of Hyperthermia in the Treatment of Cancer, 87–92. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-83260-4_11.

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Javed, Yasir, Khuram Ali, and Yasir Jamil. "Magnetic Nanoparticle-Based Hyperthermia for Cancer Treatment: Factors Affecting Heat Generation Efficiency." In Complex Magnetic Nanostructures, 393–424. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-52087-2_11.

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Caizer, Costica. "Magnetic Hyperthermia-Using Magnetic Metal/Oxide Nanoparticles with Potential in Cancer Therapy." In Metal Nanoparticles in Pharma, 193–218. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-63790-7_10.

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Caizer, Costică, Cristina Dehelean, Dorina Elena Coricovac, Isabela Simona Caizer, and Codruta Şoica. "Magnetic Nanoparticle Nanoformulations for Alternative Therapy of Cancer by Magnetic/Superparamagnetic Hyperthermia." In Nanoformulations in Human Health, 503–30. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-41858-8_22.

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Mekaru, Harutaka, Yuko Ichiyanagi, and Fuyuhiko Tamanoi. "Magnetic Nanoparticles and Alternating Magnetic Field for Cancer Therapy." In Cell-Inspired Materials and Engineering, 165–79. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-55924-3_7.

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Gopalakrishnan, Sandhya, and Kannan Vaidyanathan. "Magnetic Nanoparticles for Hyperthermia a New Revolution in Cancer Treatment." In Gels Horizons: From Science to Smart Materials, 119–32. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-1260-2_6.

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Тези доповідей конференцій з теми "Hyperthermia cancer magnetic field"

1

Qin, Zhenpeng, Neha Shah, Taner Akkin, Warren C. W. Chan, and John C. Bischof. "Thermal Analysis Measurement of Gold Nanoparticle Interactions With Cell and Biomaterial." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80554.

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The rapidly evolving field of nanomedicine focuses on the design and application of multi-functional nanoparticles for diagnosis and treatment of diseases especially cancer1. Many of these nanomaterials are designed to serve as drug delivery or image contrast agents, or even to generate heat for hyperthermia (i.e. treatment), of cancer. Heating examples include gold nanoparticles (GNPs) for photothermal therapy3, and superparamagnetic nanoparticles for magnetic fluid hyperthermia4.

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2

Jiang, Junfeng, Ruoyu Hong, Xiaohui Zhang, and Hongzhong Li. "On the in Vitro Hyperthermia of Magnetic Fluid in AC Magnetic Field." In ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer. ASMEDC, 2009. http://dx.doi.org/10.1115/mnhmt2009-18547.

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Hyperthermia therapy for cancer has attracted much attention nowadays. The study on the heat transfer in the magnetic fluid and the tumor is crucial for the successful application of magnetic fluid hyperthermia (MFH). Water-based Fe3O4 magnetic fluid is expected to be a most appropriate candidate for MFH due to the good biocompatibility, high saturation magnetization, super-paramagnetization and high chemical stability. In this paper, we explore the heat generation and transfer in magnetic fluid which is placed under an AC magnetic field. It is found that the amplitude and the frequency of alternating magnetic field, particle size and volume fraction have a pronounce influence on maximum temperature of hyperthermia.

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Kastner, Elliot J., Russell Reeves, William Bennett, Aditi Misra, Jim D. Petryk, Alicia A. Petryk, and P. Jack Hoopes. "Alternating magnetic field optimization for IONP hyperthermia cancer treatment." In SPIE BiOS, edited by Thomas P. Ryan. SPIE, 2015. http://dx.doi.org/10.1117/12.2083196.

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Stigliano, Robert V., Fridon Shubitidze, and P. Jack Hoopes. "Magnetic Nanoparticle Hyperthermia Cancer Therapy Temperature Distribution Modeling and Validation." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93123.

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The use of magnetic nanoparticles (mNP’s) in hyperthermia therapy for the treatment of cancer has been receiving increasing interest in the past few decades. It is known that heating cancerous tissues to temperatures above physiologically normal levels will cause cytotoxicity. In mNP hyperthermia, mNP’s are either injected intravenously or directly into the tumor site. In many tumor types the nanoparticles are invaginated into the cancer cells and aggregated into endosomes. Local temperature increases are achievable by exposing tumors containing mNP’s to an alternating magnetic field (AMF). The proximity of the mNP’s has a strong influence on their ability to generate heat due to inter-particle magnetic interaction effects [1, 2]. Taking this effect into account is important when modeling the heating characteristics of mNP’s.

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Deng, Zhong-Shan, and Jing Liu. "Theoretical Evaluation on the Thermal Effects of Extracellular Hyperthermia and Intracellular Hyperthermia." In 2007 First International Conference on Integration and Commercialization of Micro and Nanosystems. ASMEDC, 2007. http://dx.doi.org/10.1115/mnc2007-21263.

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Although not currently a routine cancer treatment therapy, hyperthermia is developing rather rapidly as an alternative way as part of conventional treatment for some cancers. This treatment takes advantage of the high sensitivity of tumor cell to heat. Up to now, a variety of heating methods have been established to induce temperature rises either locally in target tissue region, or over the whole body. Among them, magnetic nano-particles offer some attractive possibilities in tumor hyperthermia, which have controllable sizes ranging from a few nanometers up to tens of nanometers. The magnetic nano-particles can be made to resonantly respond to a time-varying electromagnetic (EM) field, with advantageous results related to the transfer of energy from the exciting field to the nano-particles. This heat then efficiently conducts into the surrounding diseased cells and tissues. A major concern involved in magnetic nano-hyperthermia is about the controversy that whether intracellular hyperthermia is superior to extracellular hyperthermia [1]. The potential of time-varying EM heating effects in a scale length smaller than the biological cell diameter was first addressed by Gordon et al. and termed as “intracellular hyperthermia” [2]. Since experimental validation of the thermal effects of intracellular hyperthermia is still not feasible with the current experimental technique, this problem has been studied theoretically. However, different researchers have suggested different results, and the controversy still goes on [1–3]. In order to understand the exact micro-mechanisms of EM heating involved in intracellular hyperthermia and extracellular hyperthermia, an energy analysis is presented in this study to simulate the corresponding heat transfer problems thus involved. Different from intracellular hyperthermia, the main characteristic of the extracellular hyperthermia is to heat up the target tissue by EM energy absorption only in the extracellular medium. A series of numerical calculations for both intracellular hyperthermia and extracellular hyperthermia are performed. The results will answer the question from the heat transfer mechanism whether intracellular hyperthermia is superior to extracellular hyperthermia in the thermal sense.

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Hayek, Saleh S., Ching-Jen Chen, Yousef S. Haik, and Mark H. Weatherspoon. "Analysis of Heat Generation Through-Electromagnetic Energy Conversion for Magnetic Hyperthermia Cancer Treatment." In ASME 2006 International Mechanical Engineering Congress and Exposition. ASMEDC, 2006. http://dx.doi.org/10.1115/imece2006-14147.

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Hyperthermia (HT) is a cancer treatment that utilizes a variety of heating methods to destroy cancerous tumors. A diversity of technical problems still exists regarding HT's different approaches, therapeutic potential, and evidence of effectiveness. The foremost problem is in generating and controlling heat in tumors to target cancer sites. The window of temperature for HT is between 42°C and 45°C, with the literature suggesting 43°C to be the ideal temperature for inducing apoptosis (programmed cell death). Normal cells undergo necrosis at higher temperatures than that of the specified range. To address control problems, various methods have been utilized to localize HT heating and limit its temperatures through various applicators, materials, and procedures. One method has been to implant various materials into the human body to heat tumors, a process known as Magnetic Hyperthermia (MH) as it uses magnetic nanoparticles (NP). This method is particularly useful for sending thermal energy to deep seated tumors by using ferro/ferri magnetic NP that absorb non-ionizing electromagnetic (EM) fields delivered into the human body externally. These NP have been shown to heat surrounding tissue until they reach a Curie temperature (Tc) at which generated heat is minimized (many thermodynamic properties change at Tc, such as dielectric, elastic, optical and thermal properties. Fabricated NP, due to spontaneous polarization, can heat via hysteresis losses under applied EM fields making them candidates for testing in (EM) HT systems. Various ferro- and ferromagnetic materials have been studied extensively by this group (e.g.: Ni-Cu, Ni-Co, Ni-Cr, Er, Ce, Gd, and their alloys, etc.) as candidates for HT due to their production of heat through hysteresis or magnetic spin mechanisms. With the use of these nanoparticle systems, the focus of this paper is to produce analysis of heat generation through electromagnetic energy conversion for magnetic hyperthermia cancer treatment and to investigate the heat transfer and heat generation of magnetic NP due to temperature rise upon application of externally applied AC magnetic field. Both, polarization switching and inhomogenities affect polarization orientation within a crystal. Domain switching occurs in two steps: first, the domain nucleates at critical level of applied EM field; second, the interface between the two domains propagates. Particles moving across the interface transform from one domain type to another, which leads to a release of energy in the form of heat. This, in turn, leads to a temperature rise at the interface.

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Huang, Shujuan, Amit Gupta, and Diana-Andra Borca-Tasciuc. "Sources of Experimental Errors in Specific Absorption Rate Measurement of Magnetic Nanoparticles." In ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels collocated with 3rd Joint US-European Fluids Engineering Summer Meeting. ASMEDC, 2010. http://dx.doi.org/10.1115/fedsm-icnmm2010-30796.

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Magnetic-nanoparticles cancer hyperthermia, a side effects-free, potential cancer therapy employing magnetic nanoparticle remotely heated by alternating magnetic field (AMF), is receiving considerable attention from researchers and physicians [1–3]. Specific absorption rate (SAR), which is used to quantify nanoparticles’ heat generation under the applied AMF, is defined as the thermal power per unit mass dissipated by the magnetic material [3]. SAR depends on field parameters (magnetic field strength and frequency) and material system (size and magnetic properties of nanoparticles). Accurate measurement of SAR is a critical step in enabling comparison with theoretical predictions for understanding other parameters that may affect the heat generation rate such as nanoparticle functionalization, clustering and immobilization in biological medium [4]. A main drawback is the fact that independent measurements on similar samples often provide significantly different SAR values. For example, the reported SAR of magnetite-based aqueous solution Endorem commercially available from Guerbet greatly differs among Ref. [3], [5] and [6], even when factors such as field intensity, H, and frequency, f, are taken into account.

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Su, Di, Ronghui Ma, and Liang Zhu. "Numerical Study of Nanofluid Transport in Tumors During Nanofluid Infusion for Magnetic Nanoparticle Hyperthermia Treatment." In ASME 2012 Third International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/mnhmt2012-75101.

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The application of nanostructures in hyperthermia treatment of cancer has attracted growing research interest due to the fact that magnetic nanoparticles are able to generate impressive levels of heat when excited by an external magnetic field [1–3]. Various types of nanoparticles such as magnetite and superparamagentic iron oxide nanoparticles have demonstrated great potentials in hyperthermia treatment; however many challenges need to be addressed for future applications of this method in clinical studies. One leading issue is the limited knowledge of nanoparticle distribution in tumors. Since the temperature elevation is induced as the result of the heat generation by the nanoparticles, the concentration distributions of the particles in a tumor play a critical role in determining the efficacy of the treatment. The lack of control of the nanoparticle distribution may lead to inadequacy in killing tumor cells and/or damage to the healthy tissue.

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Attaluri, Anilchandra, Ronghui Ma, and Liang Zhu. "Using MicroCT Imaging to Quantify Heat Generation Distribution Induced by Magnetic Nanoparticles." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19033.

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In the past decade, there have been renewed interests in using magnetic nanoparticles as heating agents when subjected to an alternating magnetic field in cancer treatments. Due to the technical advancement in manufacturing nano-sized magnetic particles, nanoparticle hyperthermia has emerged as an attractive alternative to costly and risky surgical procedures because of its few associated complications and targeted delivery of thermal energy to the tumor.

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Mansfield, James R., Jeffrey M. Gaudet, Gang Ren, Daniel Hensley, Patrick Goodwill, and Max Wintermark. "Abstract B7: Changing the field: Magnetic particle imaging and localized RF hyperthermia in cancer immunology." In Abstracts: AACR Special Conference on Tumor Immunology and Immunotherapy; November 17-20, 2019; Boston, MA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/2326-6074.tumimm19-b7.

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Звіти організацій з теми "Hyperthermia cancer magnetic field"

1

Panyam, Jayanth. Targeted Magnetic Hyperthermia for Lung Cancer. Fort Belvoir, VA: Defense Technical Information Center, September 2012. http://dx.doi.org/10.21236/ada568987.

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Panyam, Jayanth. Targeted Magnetic Hyperthermia for Lung Cancer. Fort Belvoir, VA: Defense Technical Information Center, September 2013. http://dx.doi.org/10.21236/ada592043.

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Panyam, Jayanth. Targeted Magnetic Hyperthermia for Lung Cancer. Fort Belvoir, VA: Defense Technical Information Center, November 2014. http://dx.doi.org/10.21236/ada620276.

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Adolphi, Natalie L. Novel Synergistic Therapy for Metastatic Breast Cancer: Magnetic Nanoparticle Hyperthermia of the Neovasculature Enhanced by a Vascular Disruption Agent. Fort Belvoir, VA: Defense Technical Information Center, April 2013. http://dx.doi.org/10.21236/ada584503.

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