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1
Levina, O. A., A. K. Evseev, M. Sh Khubutiya, A. V. Babkina, and A. K. Shabanov. "Hyperbaric oxygenation in transplantology." Transplantologiya. The Russian Journal of Transplantation 12, no. 1 (March 18, 2020): 28–41. http://dx.doi.org/10.23873/2074-0506-2020-12-1-28-41.
Повний текст джерелаАнотація:
The ability to eliminate any form of oxygen debt by transporting oxygen to organs and tissues, by dissolving it in body fluids, brings hyperbaric oxygenation to a new level of application in transplantology. The review discusses the pathophysiological aspects of hyperbaric oxygenation during ischemia and reinfusion, especially when used in transplantology, and also investigations on the use of hyperbaric oxygenation in model experiments and in clinical practice. Analysis of the efficacy of hyperbaric oxygenation therapy at various stages of the transplantation process (preconditioning, donation, organ storage, in the early and late post-transplant periods) allows us to conclude that this method should be more widely involved in transplantation practice.Authors declare no conflict of interest.
2
Tsankova, Krasimira, and Mila Dimitrova. "HISTORICAL DEVELOPMENT OF THE HYPERBARIC OXYGENATION." Journal of IMAB - Annual Proceeding (Scientific Papers) 27, no. 2 (June 7, 2021): 3772–77. http://dx.doi.org/10.5272/jimab.2021272.3772.
Повний текст джерелаАнотація:
Background: Hyperbaric oxygenation (HBO) is a treatment in which a patient breathes near 100% oxygen within a chamber at a pressure greater than one atmosphere absolute (ATA). The development of hyperbaric medicine is continuous and associated with the history of underwater activities, the development of physical laws and physiological mechanisms of breathing. Purpose: The aim of this article is to present the development of hyperbaric oxygenation internationally and nationally. Materials and Methods: We have conducted a literature review of the published works on hyperbaric oxygen therapy (HBOT) during the last 100 years. Our survey includes scientific reports and books in English and Bulgarian. Results: Three main periods of the historical development of HBOT can be defined. In the past, HBO did not have much scientific support but is extensively used in the field of medicine. We observed an increase in scientific interest in HBO during the last two decades both in our country and worldwide. The majority of the reviewed articles contained information about different aspects of HBO as clinical uses, effects, risks. HBOT has been used as a primary and adjuvant treatment for a variety of diseases for nearly 50 years in Bulgaria. The main areas of application and researches of hyperbaric oxygen therapy include diving diseases, intoxications, traumatic injuries, soft tissue infections, diabetic foot, hearing loss, some neurological disorders, etc. Conclusion: Over the past decades, hyperbaric oxygen therapy has grown rapidly worldwide in accordance with evidence-based medicine methods, and future developments to expand the knowledge are perspective.
3
Babkina, A. V., M. Sh Khubutiya, O. A. Levina, A. K. Evseev, A. K. Shabanov, I. V. Goroncharovskaya, and A. A. Medvedev. "Parameters of the oxidative-reduction system of the homeostasis in female transplant patients with tumors of the reproductive system treated with hyperbaric oxygen therapy." Transplantologiya. The Russian Journal of Transplantation 11, no. 4 (December 12, 2019): 290–300. http://dx.doi.org/10.23873/2074-0506-2019-11-4-290-300.
Повний текст джерелаАнотація:
Introduction. Studies on the effects of hyperbaric oxygenation have often been represented as animal model experiments. Currently, the number of studies on the use of hyperbaric oxygen therapy in the post-transplant period in humans is growing. The need in investigating the efficacy of hyperbaric oxygen therapy in the postoperative period in female transplant patient with tumors of the reproductive system is dictated by time.The aim of the study was to evaluate the efficacy of hyperbaric oxygen therapy in the complex treatment of transplant patients at an early stage of the postoperative period.Material and methods. We have studied the course of an early postoperative period in 8 female transplant patients with reproductive system tumors treated in N.V. Sklifosovsky Research Institute for Emergency Medicine, using hyperbaric oxygenation. The hyperbaric oxygen therapy sessions were provided in a single-patient hyperbaric chamber at 1.2–1.6 ATA for 40 minutes. The status of the redox homeostasis system was assessed based on the data of the platinum electrode open circuit potential measured in blood plasma by using the potentiometric method; and the blood plasma antioxidant activity was assessed by cyclic voltammetry.Results. The analysis of the results showed that there was a direct relationship indicating the positive effect of hyperbaric oxygen therapy on the balance status of the pro- and antioxidant systems of the body, and on the improvement of blood counts.Conclusion. The early inclusion of hyperbaric oxygen therapy in the complex treatment of transplant patients with tumors of the reproductive system contributes to a more rapid recovery of pro- and antioxidant systems of the body, blood counts.
4
Мальцева and L. Maltseva. "Hyperoxia effect on humoral and cell components of immunobiological resistance of healthy rats in experiment." Journal of New Medical Technologies. eJournal 8, no. 1 (November 5, 2014): 1–6. http://dx.doi.org/10.12737/4112.
Повний текст джерелаАнотація:
The paper contains information about hyperbaric oxygenation impact on humoral and cell components of immune-biological resistance of healthy rats. The following factors are analyzed: potency of oxygen-dependent enzyme systems (myeloperoxidase, oxidase), oxygen-independent systems (leukocyte lysozyme, cationic proteins), killing reactions of peripheral blood neutrophils, their phagocytic and oxidase reserve, complement activity and content of circulating immune complexes in the blood serum of healthy animals, which have been exposed to 60-minute sessions of hyperbaric oxygenation, over time from the 1st to the 30th day post hyperoxia period during experiment. A single session of hyperbaric oxygenation is carried out within 60 minutes (3 absolute atmospheres mode). Mechanisms of adaptation and pathological reactions formation by immune-biological surveillance system of healthy body in early and late post hyperoxia periods during experiment are considered.
The paper shows that adaptive responses, which are designed to protect the body against aggressive action of oxygen under the influence of hyperbaric oxygenation, are formed in the bodies of healthy animals.
The reactions of oxygen-dependent of phagocytes systems in conditions of hyperoxia manifested in the early stages of the research, persisting to the end of the observation and the reactions of oxygen independent - only at early stages. The humoral responses of healthy organism under hyperbaric oxygen are characterized by the change in complement activity and concentration of circulating immune complexes in blood serum. The received experimental data may be used as a theoretical explanation of indications for use of hyperbaric oxygen therapy and different hyperbaric oxygenation regimes.
5
Balestra, Costantino, and Jacek Kot. "Oxygen: A Stimulus, Not “Only” a Drug." Medicina 57, no. 11 (October 25, 2021): 1161. http://dx.doi.org/10.3390/medicina57111161.
Повний текст джерелаАнотація:
Depending on the oxygen partial pressure in a tissue, the therapeutic effect of oxygenation can vary from simple substance substitution up to hyperbaric oxygenation when breathing hyperbaric oxygen at 2.5–3.0 ATA. Surprisingly, new data showed that it is not only the oxygen supply that matters as even a minimal increase in the partial pressure of oxygen is efficient in triggering cellular reactions by eliciting the production of hypoxia-inducible factors and heat-shock proteins. Moreover, it was shown that extreme environments could also interact with the genome; in fact, epigenetics appears to play a major role in extreme environments and exercise, especially when changes in oxygen partial pressure are involved. Hyperbaric oxygen therapy is, essentially, “intermittent oxygen” exposure. We must investigate hyperbaric oxygen with a new paradigm of treating oxygen as a potent stimulus of the molecular network of reactions.
6
Polyakov, K. N., S. V. Levonchuk, and M. A. Laperishvili. "Hyperbaric oxygen therapy in rehabilitation of patients after COVID‑19." Medical alphabet, no. 3 (April 16, 2022): 47–49. http://dx.doi.org/10.33667/2078-5631-2022-3-47-49.
Повний текст джерелаАнотація:
Severe complications of COVID‑19 are pneumonia and the development of acute respiratory distress syndrome, which is accompanied by hypoxia. Tissue hypoxia increases against the background of inflammatory reactions and hypercoagulation. Hyperbaric oxygenation can effectively reduce systemic hypoxia, improve blood circulation, has a beneficial effect on reducing the severity of the inflammatory condition by modulating oxidative stress, including lipid peroxidation, and increasing antioxidant enzymes. A review of clinical studies conducted in different countries shows the overall effectiveness of systemic maintenance therapy with the inclusion of hyperbaric oxygenation, which reduces the use of artificial ventilation and reduces the mortality rate of severely ill patients with COVID‑19. The article presents the results of our own research on the rehabilitation of 10 patients who had a severe form of COVID‑19. The inclusion in the rehabilitation of COVID‑19 patients of daily sessions of hyperbaric oxygenation in ‘soft’ modes (1,4–1,6 ATA) in combination with respiratory and physical gymnastics showed a positive effect and safety. In patients, shortness of breath decreased, blood saturation indicators improved, cognitive functions decreased, the severity of anxiety and depression decreased, and exercise tolerance increased.
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Lynn, Michael, and William A. Friedman. "HYPERBARIC OXYGEN IN THE TREATMENT OF A RADIOSURGICAL COMPLICATION." Neurosurgery 60, no. 3 (March 1, 2007): E579. http://dx.doi.org/10.1227/01.neu.0000255343.41206.6f.
Повний текст джерелаАнотація:
Abstract OBJECTIVE Hyperbaric oxygenation is a rarely used method of treatment for steroid-refractory radiation-induced edema after stereotactic radiosurgery. We present its successful implementation for a radiosurgical complication after the treatment of a deep, large arteriovenous malformation. We also review the literature on hyperbaric oxygenation for radiation-induced complications. CLINICAL PRESENTATION A 25-year-old man underwent radiosurgical treatment for a large arteriovenous malformation. Three years later, substantially smaller remaining nidus was retreated. Five months after that treatment, the patient developed edema around the nidus and hemiparesis. This problem was refractory to high-dose steroids. INTERVENTION The patient underwent a course of 25 hyperbaric oxygenation treatments. Within 1 month, the edema and hemiparesis had improved, allowing steroids to be tapered. A follow-up examination 1 year later revealed complete thrombosis of the arteriovenous malformation and minimal neurological deficit. CONCLUSION This technical case report adds to the few studies in the literature suggesting that hyperbaric oxygenation therapy, in conjunction with a slow steroid taper, is a reasonable addition to the treatment armamentarium for radiation-induced cerebral edema associated with clinically evident neurological deficits.
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Mitrović, Ana, Branka Nikolić, Svetlana Dragojević, Predrag Brkić, Aleksandar Ljubić, and Tomislav Jovanović. "Hyperbaric Oxygenation as a Possible Therapy of Choice for Infertility Treatment." Bosnian Journal of Basic Medical Sciences 6, no. 2 (May 20, 2006): 21–24. http://dx.doi.org/10.17305/bjbms.2006.3168.
Повний текст джерелаАнотація:
Endometrial sonographic and color doppler features can be used to predict the occurrence of pregnancy in natural or stimulated cycles. Implantation will usually only take place if the endometrium has reach a certain stage of vascularisation and development. The aim of this study was to evaluate endometrial development -- endometrial thickness and reflectivity , subendometrial, endometrial and uterine perfusion, after hyperbaric oxygenation, using transvaginal color doppler. During a three years period 32 women with unexplained infertility were entered into a randomised study. The patients were treated in multiplaced HAUX chamber at pressure of 2.3 ATA during 70 minutes, 7 days consecutively beginning with day 5th of menstrual cycle. The evaluation of effects of hyperbaric oxygen therapy was carried out by transvaginal color doppler sonography which was continuously used starting from 8th day of menstrual cycle until the ovulation in the cycles when the therapy was applied , one month before and one month after the therapy. Folliculometry in the cycles when hyperbaric oxygen therapy at 2.3 ATA was applied, indicated an excellent response of endometrium. Thickness of endometrium at the time of ovulation was 11.0 +/- 2.6 mm. Desirable quality of endometrium was significantly better in the cycle when HBO therapy had been applied (p< 0.001). The doppler flowmetry of the uterine arteries indicated that the uterine blood vessel resistance was slightly higher than expected. Mapping of subendometrial blood vessels in the cycles covered by hyperbaric oxygen therapy showed the intensive capillary network of endometrium with low resistance Ri< 0.45. The oxygen used under higher pressure -- oxygen as a drug , may have an extraordinary significance for better outcome of pregnancy implantation by improving endometrial receptivity. If endometrial receptivity is conditioned by adequate vascularisation and oxygenation, then hyperbaric oxygen therapy is the treatment of choice.
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Skiba, Małgorzata, and Agnieszka Pedrycz. "Influence of hyperbaric oxygenation and its use in urinary tract diseases." Polish Hyperbaric Research 56, no. 3 (September 1, 2016): 25–32. http://dx.doi.org/10.1515/phr-2016-0016.
Повний текст джерелаАнотація:
Abstract In this publication, we adduce examples of the use of hyperbaric oxygen therapy in urinary tract diseases. Hyperbaric oxygen therapy has been proved to have a positive influence on the kidneys of animals with diabetes, sepsis or undergoing chemotherapy. In the literature, we can also find many examples of the use of hyperbaric therapy with good clinical outcomes in human patients with prostatic hypertrophy, pyelonephritis, and hemorrhagic cystitis. The first trials of this kind of treatment of urinary tract diseases were started at the end of the twentieth century. In spite of the promising results, and numerous reports on the effectiveness of this non-invasive method of treatment, it is not currently used on a regular basis. Because many factors such as time, multiple applications, the parameters used in the hyperbaric chamber as well as the medications taken by the patient affect the quality of the result, further studies are needed to make hyperbaric therapy more suitable and safer for each patient.
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Wolański, Władysław. "Research on the Possibility of Treating Streptococcal Infections with Hyperbaric Oxygenation." Polish Hyperbaric Research 70, no. 1 (March 1, 2020): 43–46. http://dx.doi.org/10.2478/phr-2020-0003.
Повний текст джерелаАнотація:
AbstractThe aim of the study was to determine the effect of the application of hyperbaric oxygen therapy on the course of an infection with group A type T-3 hemolytic β streptococcus. Experiments were carried out on Porton white mice and in vitro blood plates. General and local infections with streptococci were induced in animals. The infected animals were treated with hyperbaric oxygenation. The lethal effect of infection was significantly inhibited using hyperbaric oxygenation on the first and second day following the infection.
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MENON, DOUGLAS NEUMAR, LETÍCIA TEIXEIRA, NATALHA BRISTOT PAUROSI, and MARCIO EDUARDO BARROS. "Effects of heparin and hyperbaric oxygenation on necrosis reduction in an animal model for degloving injuries." Revista do Colégio Brasileiro de Cirurgiões 44, no. 1 (February 2017): 64–71. http://dx.doi.org/10.1590/0100-69912017001014.
Повний текст джерелаАнотація:
ABSTRACT Objective: to evaluate the efficacy of the treatment with hyperbaric oxygen therapy or with topical and intralesional heparin in an animal model of degloving lesions. Methods: we conducted an experimental study with adult, male Wistar rats submitted to degloving of the left hind limb and divided into four groups according to the treatment: Group 1 (control) - without treatment; Group 2 (Heparin) - intralesional application at the time of surgery and topically, in the postoperative period, with heparin spray 10,000IU/mL; Group 3 (hyperbaric oxygenation) - daily sessions of 30 minutes in a hyperbaric chamber with 100% oxygen and 2 ATA pressure; Group 4 (positive control) - administration of a single dose of 45 mg/kg of intraperitoneal allopurinol. On the seventh day, we killed the animals, removed the cutaneous flaps and measured the total and necrotic areas, as well as computed the percentage of necrotic area. Results: the mean percentage of necrosis in the control group was 56.03%; in the positive control group it was 51.36% (p<0.45); in the heparin group, 42.10% (p<0.07); and in the hyperbaric oxygen therapy group, 31.58% (p<0.01) . Conclusion: both hyperbaric oxygen and heparin therapies were effective in reducing the percentage of necrosis in the model studied, although only the hyperbaric oxygenation showed statistical significance.
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Baitule, Sudhanshu, Aaran H. Patel, Narasimha Murthy, Sailesh Sankar, Ioannis Kyrou, Asad Ali, Harpal S. Randeva, and Tim Robbins. "A Systematic Review to Assess the Impact of Hyperbaric Oxygen Therapy on Glycaemia in People with Diabetes Mellitus." Medicina 57, no. 10 (October 19, 2021): 1134. http://dx.doi.org/10.3390/medicina57101134.
Повний текст джерелаАнотація:
Background and Objectives: Hyperbaric oxygen is a recognised treatment for a range of medical conditions, including treatment of diabetic foot disease. A number of studies have reported an impact of hyperbaric oxygen treatment on glycaemic control in patients undergoing treatment for diabetic foot disease. There has been no systematic review considering the impact of hyperbaric oxygen on glycaemia in people with diabetes. Materials and Methods: A prospectively PROSPERO-registered (PROSPERO registration: CRD42021255528) systematic review of eligible studies published in English in the PUBMED, MEDLINE, and EMBASE databases, based on the following search terms: hyperbaric oxygen therapy, HBO2, hyperbaric oxygenation, glycaemic control, diabetes, diabetes Mellitus, diabetic, HbA1c. Data extraction to pre-determined piloted data collection form, with individual assessment of bias. Results: In total, 10 eligible publications were identified after screening. Of these, six articles reported a statistically significant reduction in blood glucose from hyperbaric oxygen treatment, while two articles reported a statistically significant increase in peripheral insulin sensitivity. Two articles also identified a statistically significant reduction in HbA1c following hyperbaric oxygen treatment. Conclusions: There is emerging evidence suggesting a reduction in glycaemia following hyperbaric oxygen treatment in patients with diabetes mellitus, but the existing studies are in relatively small cohorts and potentially underpowered. Additional large prospective clinical trials are required to understand the precise impact of hyperbaric oxygen treatment on glycaemia for people with diabetes mellitus.
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Chen, Pingrun, Yina Li, Xian Zhang, and Yan Zhang. "Systematic review with meta-analysis: effectiveness of hyperbaric oxygenation therapy for ulcerative colitis." Therapeutic Advances in Gastroenterology 14 (January 2021): 175628482110233. http://dx.doi.org/10.1177/17562848211023394.
Повний текст джерелаАнотація:
Background and aims: Hyperbaric oxygenation therapy has been used in the treatment of ulcerative colitis in the past few years. However, its efficacy still remains unclear. The aim of the study was to investigate the efficacy of hyperbaric oxygen combination therapy in patients with ulcerative colitis. Methods: We conducted a comprehensive study search up to September 2020, from the online databases Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure, WanFang and VIP. Results: Thirteen studies comprising 780 patients were included. We found that compared with conventional therapy, hyperbaric oxygen combination therapy was superior in reaching clinical remission [risk ratio (RR)=1.62; 95% confidence interval (CI) 1.42 to 1.84; p < 0.001] and clinical response (RR=1.29; 95% CI 1.21 to 1.38; p < 0.001), with lower disease activity scores [standard mean difference (SMD)= −1.19; 95%CI −1.74 to −0.65; p < 0.001]. An obvious reduction of serum levels of tumor necrosis factor-α (SMD= −1.96; 95%CI −2.50 to −1.41; p < 0.001) and interleukin (IL)-6 (SMD= −2.49; 95% CI −2.84 to −2.15; p < 0.001), and elevation of IL-10 level (SMD=2.40; 95% CI 0.68 to 4.12; p = 0.006) were also observed. Conclusion: Hyperbaric oxygen combination therapy was effective in patients with ulcerative colitis, and has potential as a complementary method for its treatment.
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CALIN, Mihaela Antonina, Adrian MACOVEI, and Dragos MANEA. "Assessment of the hyperbaric oxygen therapy effects in distal femoral necrosis using hyperspectral imaging." Balneo and PRM Research Journal, Vol.12, no.2 (June 1, 2021): 123–28. http://dx.doi.org/10.12680/balneo.2021.431.
Повний текст джерелаАнотація:
Introduction. Hyperbaric oxygen therapy is a treatment option for an increasing number of conditions. The aim of this study was to assess its therapeutic effects in femoral condylar necrosis as well as in normal tissue using hyperspectral imaging. Material and method. A 47-year-old female patient diagnosed with avascular necrosis of the medial femoral condyle was included in this study. The patient received hyperbaric oxygen therapy for two consecutive days (the first day: three stages of 30 min each, separated by two breaks of 5 min at pO2 = 2 ATA; the second day: three stages of 30 min each, separated by two breaks of 5 min at pO2 = 2.4 ATA). The effects of hyperbaric oxygen therapy on the affected area (patient’s knee) and normal (patient’s hand) tissues oxygenation were assessed before and after each treatment session using hyperspectral imaging. Results and discussions. The results showed that hyperspectral imaging is quite good for monitoring the hyperbaric oxygen therapy efficacy in affected areas, even with deep tissue problems. Conclusions. In conclusion, the hyperspectral imaging-based approach for monitoring hyperbaric oxygen therapy could support physicians in extracting prognostic information and making the right treatment decisions. Keywords: bone necrosis, image analysis, maps, oxyhemoglobin, deoxyhemoglobin, oxygen saturation,
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Castro, Joyce Beatriz de Abreu, and Beatriz Guitton Renaud Baptista Oliveira. "Hyperbaric oxygen therapy in the treatment of tissular lesions." Online Brazilian Journal of Nursing 2, no. 3 (October 20, 2004): 36–45. http://dx.doi.org/10.17665/1676-4285.20034885.
Повний текст джерелаАнотація:
This work addresses the therapy with hyperbaric oxygen, considering the importance of the nurses accompanying the technological advancements in the area of health. It has as aim to describe the use of the hyperbaric oxygenation, including as acceleration therapy of the cicatrisation process of tissular lesions (wounds), which is the area of working of the researchers. The methodology used was a revision of the bibliography on the theme; the research was performed in books, publications and electronic documents, comprising the period from 1999 through 2003; complemented by visits to two private institutions in Rio de Janeiro city that possess different models of hyperbaric chamber, and whose aim was to know the equipment and the service. In the results it is described the therapeutic indications, the benefits, as well as the cares and contraindications. Alerting on the importance of the multi-professional assistance, with comprehensive evaluation of the general conditions of the patient with tissular wound, with emphasis to the importance of the nurse’s work with this patients.
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SONN, JUDITH, ELHANAN MEIROVITHZ, and AVRAHAM MAYEVSKY. "HYPERBARIC HYPEROXIA AND THE BRAIN IN VIVO: THE BALANCE BETWEEN THERAPY AND TOXICITY." Journal of Innovative Optical Health Sciences 01, no. 02 (October 2008): 185–93. http://dx.doi.org/10.1142/s1793545808000200.
Повний текст джерелаАнотація:
Hyperbaric oxygenation (HBO) treatment protocols utilize low pressures up to 3 ATA. Higher pressures may induce side effects such as convulsions due to brain toxicity. The optimal HBO pressure allowing for maximal therapy and minimal toxicity is under controversy. However, it can be evaluated by monitoring oxygen delivery, saturation, and consumption. In this study, the monitoring system fixed on the rats' brain cortex included a time-sharing fluorometer-reflectometer for monitoring mitochondrial NADH and hemoglobin oxygenation ( HbO 2) combined with Laser Doppler Flowmetry (LDF) for blood-flow monitoring. Rats were located in a hyperbaric chamber and exposed to different pressures. The HBO pressure caused an increase in HbO 2 and a decrease in NADH in proportion to the increase in hyperbaric pressure, up to a nearly maximum effect at 2.5 ATA. At 6 ATA, 15 minutes before convulsions started, blood volume and NADH started to increase, while tissue O 2 supply by hemoglobin remained stable. Oxygen pool includes oxygen dissolved in the plasma and also bounded to hemoglobin. Above 2.5 ATA, hemoglobin is fully saturated and the oxygen pool nourishment derives only from the oxygen dissolved in the plasma, exceeding the physiological ability for auto-regulation; hence, homeostasis is disturbed and convulsions appear. This information is vital because pressures around 2.5 ATA–3 ATA are standard clinically applied pressures used to treat most of the pathophysiological problems considering the potential benefit which must be balanced against the potential toxicity. This study enables, for the first time, to evaluate the oxygenation level of hemoglobin in the microcirculation. Furthermore, our study showed that additional oxygen pressure (above 2.5 ATA) caused brain oxygen toxicity within a short variable period of time after the pressure elevation.
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Belic, Branislava, and Marko Cincovic. "Impact of oxygen toxic action on the erythrocyte membrane and possibility of estimating central nervous system function disturbances." Vojnosanitetski pregled 68, no. 7 (2011): 539–43. http://dx.doi.org/10.2298/vsp1107539b.
Повний текст джерелаАнотація:
Background/Aim. Prolonged exposure to hyperbaric oxygen leads to changes of erythrocytes shape as a consequence of toxic effects of oxygen on the erythrocyte membrane. The aim of this study was to examine the association between occurance of pathological forms of erythrocytes at different time from the start of hyperbaric oxygenation and the moment of convulsions occurrence, an interrelationship of different pathological forms of erythrocytes during exposure to hyperbaric oxygenation, as well as the correlation between the presence of ruptured erythrocytes and function of central nervous system (CNS) after completion of hyperbaric treatment. Methods. Sixty laboratory mice, Mus musculus, were exposed to the wholly-oxygen pressure of 3.5 absolute atmospheres (ATA). Blood was collected at the 32nd, 34th, 36th, 38th and 40th minutes after the exposure to oxygen. Pathological forms of erythrocytes were examined by electron microscopy. A moment of convulsions occurrence was registered in all animals. After decompression neurological examinations of experimental animals were perfomed. The Pearson's coefficient of correlation, and linear regression equations for the parameters outlined in the aim of the study were calculated. Results. Hyperbaric oxygen caused damages of erythrocytes at the 34th minute after beginning of the treatment. Various forms of abnormal red blood cells occured, and immediately before the occurrence of irreversible changes (erythrocyte membrane rupture) echinocyte shape was dominated. A significant correlation between the number of damaged red blood cells at 34th minute and their number at the 36th, 38th and 40th minute was found. Convulsions were diagnosed significantly earlier in mice with a greater number of damaged red blood cells (p < 0.01). There was a negative correlation between the number of irreversiblly damaged red blood cells (ruptured) at the 40th minute and neurological score in the studied animals (p < 0.05). Conclusion. The analysis of altered erythrocytes during hyperbaric oxygenation could predict a moment of seizures occurrence, and therefore the duration of the therapy with hyperbaric oxygen. Ehinocytes indicate impending rupture of red blood cells and a possible occurrence of seizures. An increased number of ruptured red blood cells may also even indicate the potential burden of CNS after cessation of hyperbaric oxygenation.
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Pejović, Teodora, Sanjin Kovačević, Predrag Brkić, and Jelena Nesović-Ostojić. "Hyperbaric oxygenation as the pretreatment and therapy in ischemia-reperfusion injury." Zdravstvena zastita 51, no. 3 (2022): 54–65. http://dx.doi.org/10.5937/zdravzast51-40055.
Повний текст джерелаАнотація:
Tissue ischemia means insufficient blood flow to a certain area of the body. Interruption of the arterial blood supply leads to an imbalance between metabolic supply and demand and the development of tissue hypoxia. Tissue hypoxia induces metabolic changes that result in inflammation, increased production of reactive oxygen species, and cell death. If adequate blood flow is established in the ischemic tissue, there will be an increase in cellular damage, which is referred to as ischemic-reperfusion injury. Ischemia and ischemia-reperfusion injury are at the root of numerous diseases widely present in modern society, such as myocardial infarction, cerebral insult, acute kidney injury. For now, there is no way to directly affect cellular hypoxia, but the clinical treatment of hypoxic conditions is aimed at modulating global hypoxemia and increasing the amount of oxygen dissolved in the blood. Hyperbaric oxygenation (HBO) is a treatment during which the patient breathes 100% oxygen under a pressure of at least 1.4 atmospheres. Although the use of hyperbaric therapy was recorded as early as the 17th century, today this treatment is approved for a few indications.
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Levina, O. A., A. K. Еvseev, A. K. Shabanov, V. V. Kulabukhov, N. Y. Kutrovskaya, I. V. Goroncharovskaya, K. A. Popugaev, D. A. Kosolapov, D. S. Slobodeniuk, and S. S. Petrikov. "The Safety of Hyperbaric Oxygen Therapy in the Treatment of Covid-19." Russian Sklifosovsky Journal "Emergency Medical Care" 9, no. 3 (October 22, 2020): 314–20. http://dx.doi.org/10.23934/2223-9022-2020-9-3-314-320.
Повний текст джерелаАнотація:
Relevance. Acute respiratory infection COVID-19 caused by the SARS-CoV-2 (2019-nCov) coronavirus is severe and extremely severe in 15—20% of cases, which is accompanied by the need for respiratory support. Hyperbaric oxygenation is recognized as an effective therapy for replenishing any form of oxygen debt.Aim of study. To study the safety of HBO use in patients with COVID-19.Material and metods. We examined 32 patients with the diagnosis “Coronavirus infection caused by the virus SARS-CoV-2” (10 — moderately severe patients (CT 1–2), 22 — patients in serious condition (CT 3–4), who received course of hyperbaric oxygenation (HBO). The procedures were carried out in a Sechrist 2800 chamber (USA) at a mode of 1.4–1.6 AT for no more than 60 minutes. In total, the patients received 141 HBO sessions. Before and after each HBO session, the subjective indicators of the patient’s condition were assessed and the blood oxygen saturation was measured.Results. An algorithm for HBO course management was developed, which consists in using “soft” modes (up to 1.4 AT) during the first session, followed by pressure adjustment (not higher than 1.6 AT) during the course to achieve maximum therapeutic effect and comfort for the patient. Against the background of the HBO course, the patients showed an increase in blood oxygen saturation in patients in both surveyed groups, as well as positive dynamics in the form of a decrease in shortness of breath, an improvement in general well-being.Conclusion. The inclusion of daily sessions (at least 4) of hyperbaric oxygenation in “soft” modes (1.4–1.6 ATA) in the complex therapy for COVID-19 has shown its safety and preliminary positive effect on the subjective state of the examined patients and the dynamics of blood oxygen saturation.
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Petrikov, S. S., A. K. Evseev, O. A. Levina, A. K. Shabanov, I. V. Goroncharovskaya, N. A. Potapova, D. S. Slobodeniuk, and A. A. Grin. "The effectiveness of the inclusion of hyperbaric oxygenation in the complex therapy of patients with COVID-19: retrospective study." Marine Medicine 8, no. 3 (October 22, 2022): 48–61. http://dx.doi.org/10.22328/2413-5747-2022-8-3-48-61.
Повний текст джерелаАнотація:
INTRODUCTION: The pandemic of novel coronavirus disease (COVID-19) caused by the SARS-CoV-2 virus has forced physicians to reconsider traditional approaches to the treatment of patients with viral pneumonia and acute respiratory distress syndrome, when normobaric oxygenation methods were ineffective. The way out of this situation was the inclusion of hyperbaric oxygenation in the complex therapy of patients with COVID-19, as a recognized means of eliminating any form of oxygen debt due to more efficient delivery of oxygen to organs and tissues. OBJECTIVE: To evaluate the effectiveness of hyperbaric oxygenation in the complex therapy of patients with a novel coronavirus infection with severe lung damage (more than 50%). MATERIALS AND METHODS: We examined 75 patients with the diagnosis «Coronavirus infection caused by the virus SARS-CoV-2» (64 patients with CT-3, 11 patients with CT-4), 50 of whom were prescribed a course of hyperbaric oxygen therapy (HBOT). The procedures were carried out in a Sechrist 2800 resuscitation pressure chamber (USA) at 1.4–1.6 ATA for no more than 60 minutes. Before and after each HBOT session, subjective indicators of the patients’ condition were assessed and blood oxygen saturation was measured. In addition, the dynamics of the level of leukocytes, platelets, ALT, AST and C-reactive protein were evaluated. In order to analyze oxygen support, the type (low-flow oxygen therapy, high-flow oxygen therapy) and daily oxygen consumption were recorded.RESULTS: The inclusion of hyperbaric oxygenation in the complex therapy of patients with a novel coronavirus infection led to a significant increase in the level of SpO2 by the 7th day in the study group to 92% (89; 94) vs. 88% (87; 92) in the control group (p=0.011), and by 14th day to 96% (95; 97) vs. 95% (90; 96) (p<0.001). This circumstance led to a significant decrease in the number of patients requiring additional oxygen support, which was 94% in the study group and 100% in the control group by the 7th day, and 16% in the study group and 44% in the control group by the 14th day. In particular, the number of patients requiring high-flow oxygen therapy in the study group decreased from 34% on the 5th day to 2% on the 14th day, while in the control group over the same period there was a decrease from 60% to 32%. When analyzing the volumetric oxygen consumption in the study group, even taking into account the oxygen consumption for hyperbaric oxygenation, a decrease in the average daily oxygen consumption was recorded from 13.9 L/min on the 5th day to 9.3 L/min on the 14th day, while in the control group for the same period from 17.2 L/min to 14.5 L/min. The length of stay of patients in the intensive care unit in the study group was 10 (8; 12) vs. 13 (11; 23) bed-days (p=0.002) in the control group, and the total length of hospitalization was 16 (13.3; 20) vs. 21 (19; 29) bed-days (p><0.001) in the study and control groups, respectively. DISCUSSION: The early inclusion of hyperbaric oxygen therapy in the complex therapy of patients with a new coronavirus infection led to a significant increase in the level of SpO2 starting from the 7th day. This circumstance led to a significant decrease in number of patients requiring additional oxygen support in the study group compared to the control. This, in turn, affected the reduction in volumetric oxygen consumption in the study group, even taking into account the oxygen consumption on hyperbaric oxygenation. In addition, in the study group, positive dynamics according to CT data, a more rapid decrease in the level of C-reactive protein, were more often recorded. All these observations indicate a more rapid normalization of the state of the body due to the elimination of hypoxia, a decrease in the inflammatory response and restoration of lung function in patients who underwent hyperbaric oxygen therapy. CONCLUSION: The inclusion of HBO in the complex therapy of patients with a new coronavirus infection with severe lung damage (more than 50%) allows to stabilize the condition in a short time due to a more intensive decrease in the degree of lung damage according to CT data, early refusal of additional oxygen support, improvement of the psycho-emotional state, which in generally leads to a reduction in the length of stay of patients both in the ICU and in the hospital department.>< 0.001). This circumstance led to a significant decrease in the number of patients requiring additional oxygen support, which was 94% in the study group and 100% in the control group by the 7th day, and 16% in the study group and 44% in the control group by the 14th day. In particular, the number of patients requiring high-flow oxygen therapy in the study group decreased from 34% on the 5th day to 2% on the 14th day, while in the control group over the same period there was a decrease from 60% to 32%. When analyzing the volumetric oxygen consumption in the study group, even taking into account the oxygen consumption for hyperbaric oxygenation, a decrease in the average daily oxygen consumption was recorded from 13.9 L/min on the 5th day to 9.3 L/min on the 14th day, while in the control group for the same period from 17.2 L/min to 14.5 L/min. The length of stay of patients in the intensive care unit in the study group was 10 (8; 12) vs. 13 (11; 23) bed-days (p=0.002) in the control group, and the total length of hospitalization was 16 (13.3; 20) vs. 21 (19; 29) bed-days (p< 0.001) in the study and control groups, respectively.DISCUSSION: The early inclusion of hyperbaric oxygen therapy in the complex therapy of patients with a new coronavirus infection led to a significant increase in the level of SpO2 starting from the 7th day. This circumstance led to a significant decrease in number of patients requiring additional oxygen support in the study group compared to the control. This, in turn, affected the reduction in volumetric oxygen consumption in the study group, even taking into account the oxygen consumption on hyperbaric oxygenation. In addition, in the study group, positive dynamics according to CT data, a more rapid decrease in the level of C-reactive protein, were more often recorded. All these observations indicate a more rapid normalization of the state of the body due to the elimination of hypoxia, a decrease in the inflammatory response and restoration of lung function in patients who underwent hyperbaric oxygen therapy.CONCLUSION: The inclusion of HBO in the complex therapy of patients with a new coronavirus infection with severe lung damage (more than 50%) allows to stabilize the condition in a short time due to a more intensive decrease in the degree of lung damage according to CT data, early refusal of additional oxygen support, improvement of the psycho-emotional state, which in generally leads to a reduction in the length of stay of patients both in the ICU and in the hospital department.
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Olszański, Romuald, Piotr Siermontowski, Dariusz Juszczak, Zbigniew Dąbrowiecki, and Agnieszka Pedrycz. "A Case of Cutaneous Leishmaniasis Treated with Hyperbaric Oxygen Therapy." Polish Hyperbaric Research 57, no. 4 (December 1, 2016): 39–41. http://dx.doi.org/10.1515/phr-2016-0024.
Повний текст джерелаАнотація:
Abstract Cutaneous leishmaniasis in Poland is an imported disease mainly occurring in tourists who travelled to tropical countries. Cutaneous symptoms occur as late as between ten and twenty days following the return from the tropics. Lesions connected with cutaneous leishmaniasis were most commonly diagnosed by Polish doctors as furuncle, ecthyma or ulceration and ineffectively treated for several weeks with antibiotics. The paper presents the case of leishmaniasis in a 30-year-old male with an ulceration of the left shank, ineffectively treated with antibiotics over a period of four months. The ulceration was healed completely only after leishmaniasis was diagnosed and following the application of a treatment based on antimony derivatives, followed by hyperbaric oxygenation performed in a hyperbaric chamber.
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Bollmann, Patricia Weinschenker, Andréa Kazumi Shimada, Nilceo Schwery Michalany, Ana Rita de Araújo Burgos Manhani, and Auro del Giglio. "Livedoid vasculopathy: fast involution after anticoagulant and hyperbaric oxygen therapy." Einstein (São Paulo) 9, no. 2 (June 2011): 212–15. http://dx.doi.org/10.1590/s1679-45082011rc1676.
Повний текст джерелаАнотація:
The livedoid vasculopathy is a rare condition characterized by the presence of recurrent painful ulcers in distal extremities of lower limbs. Histologically there is thickness of dermal vessels, occlusion of its light by fibrin thrombi associated with minimal inflammatory infiltrate. It might occur as an isolated condition or be associated with an underlying systemic disease, including coagulation and collagen disorders, or neoplasms. Because it is a rare disease there is no consensus for its treatment. We report a case of a 41-year-old man with painful ulcers in the lower extremities. We did not find any associated diseases. The lesions improved dramatically after treatment with anticoagulant and hyperbaric therapy. We concluded that anticoagulation associated with hyperbaric oxygenation may be benefit for the treatment of patients with livedoid vasculopathy. However, further studies should be done with a larger population to confirm our results.
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Guan, Ya, Hong Niu, Zhongting Liu, Yu Dang, Jie Shen, Mohamed Zayed, Liang Ma, and Jianjun Guan. "Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation." Science Advances 7, no. 35 (August 2021): eabj0153. http://dx.doi.org/10.1126/sciadv.abj0153.
Повний текст джерелаАнотація:
Nonhealing diabetic wounds are common complications for diabetic patients. Because chronic hypoxia prominently delays wound healing, sustained oxygenation to alleviate hypoxia is hypothesized to promote diabetic wound healing. However, sustained oxygenation cannot be achieved by current clinical approaches, including hyperbaric oxygen therapy. Here, we present a sustained oxygenation system consisting of oxygen-release microspheres and a reactive oxygen species (ROS)–scavenging hydrogel. The hydrogel captures the naturally elevated ROS in diabetic wounds, which may be further elevated by the oxygen released from the administered microspheres. The sustained release of oxygen augmented the survival and migration of keratinocytes and dermal fibroblasts, promoted angiogenic growth factor expression and angiogenesis in diabetic wounds, and decreased the proinflammatory cytokine expression. These effects significantly increased the wound closure rate. Our findings demonstrate that sustained oxygenation alone, without using drugs, can heal diabetic wounds.
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Yasuhara, Hirotaka, Hiromichi Naito, Yoshinori Kosaki, Yasuaki Yamakawa, Atsuyoshi Iida, Tetsuya Yumoto, Hirotsugu Yamamoto, et al. "Emphysematous cystitis successfully treated with hyperbaric oxygen therapy: case report." Undersea and Hyperbaric Medicine 45, no. 6 (November 1, 2018): 701–3. http://dx.doi.org/10.22462/11.12.2018.13.
Повний текст джерелаАнотація:
Emphysematous cystitis is an uncommon acute infection of the underlying bladder musculature and mucosa, caused by gas-producing organisms. Here we describe an 87-year-old woman with diabetes mellitus and emphysematous cystitis who was successfully treated with hyperbaric oxygen (HBO2) therapy. Her predisposition of diabetes and infection with gas-producing bacteria was considered to precede the development of emphysematous cystitis. Computed tomography revealed gas accumulation in the bladder wall and lumen. Antibiotics and HBO2therapy were administered. HBO2 therapy may be beneficial due to the improvement in oxygenation of the tissues affected by the disease. HBO2 is a useful adjunct therapy for the management of severe emphysematous cystitis.
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Kopytov, Dmitry A., Il’ya V. Bychenko, and Andrej V. Kopytov. "Influence of oxygen therapy methods in comprehensive treatment on cognitive functions at correction of alcohol withdrawal syndrome." Neurology Bulletin LII, no. 2 (October 19, 2020): 52–58. http://dx.doi.org/10.17816/nb33772.
Повний текст джерелаАнотація:
Aim.Based on the application of methods of normoxic therapeutic compression and hyperbaric oxygenation incombination with pharmacotherapy for the relief of cognitive impairment in alcohol withdrawal syndrome (AWS), to evaluate the effectiveness of their use to optimize the treatment process.
Methods.160patients with AWS were examined: 62people underwent hyperbaric oxygenation and 56normoxic therapeutic compression sessions along with symptomatic pharmacotherapy, 42with drugs in accordance with medical care protocols. To assess the severity of the manifestations of AWS, the CIWA-A scale was used. Diagnosis and clinical verification of the diagnosis of alcohol dependence was carried out in accordance with the research criteria of the ICD-10 and AUDIT. To study cognitive impairment, the Schulte table technique was used.
Results.The use of the method of normoxic therapeutic compression in the complex treatment of AWS increases the mental performance after the first day of therapy by 4.6times, after the third day of therapy, 3.18times, after the seventh day of therapy, 3.25times, compared with drugs.
Conclusion.Oxygen therapy methods in combination with pharmacotherapy should be used when stopping cognitive impairment in alcohol withdrawal syndrome, which will increase the effectiveness of treatment and avoid possible cognitive impairment in pharmacotherapy.
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Aleixo, Catarina, Ricardo Santos Pereira, Filipe Lima Santos, Henrique Sousa, José Carlos Soares, and João Pedro Maia Gonçalves. "Hyperbaric oxygenation therapy treatment option in perioperative visual loss in spine surgery." International Journal of Research in Orthopaedics 7, no. 2 (February 23, 2021): 395. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20210635.
Повний текст джерелаАнотація:
<p class="abstract">Perioperative vision loss (POVL) is a catastrophic complication of spine surgery and several risk factors are identified. As spine fusion surgery is rising in number, POVL incidence is increasing. Preventive strategies can decrease the risk of this complication. Prognosis depends on the level of occlusion and how quickly oxygen supply can be restored to retina. We present a 65-year-old female patient with multiple cardiovascular risk factors that who underwent lumbar fusion. Upon waking up from anesthesia, the patient reported total loss of vision in her left eye. An occlusion of the central retinal artery due to a probable embolic cause was diagnosed and the patient promptly started treatment with anti-aggregation therapy and hyperbaric oxygen therapy (HBOT) with good results. The combination of HBOT with anti-aggregation therapy may have had a synergistic effect contributing to the good outcome presented in this case and may be a good option for the treatment of this patients. </p>
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Daniel, Rosemary Aparecida Furlan, Vinícius Kannen Cardoso, Emanuel Góis Jr, Rogério Serafim Parra, Sérgio Britto Garcia, José Joaquim Ribeiro da Rocha, and Omar Féres. "Effect of hyperbaric oxygen therapy on the intestinal ischemia reperfusion injury." Acta Cirurgica Brasileira 26, no. 6 (December 2011): 463–69. http://dx.doi.org/10.1590/s0102-86502011000600010.
Повний текст джерелаАнотація:
PURPOSE: Adequate tissue oxygenation is essential for healing. Hyperbaric oxygen therapy (HBOT) has potential clinical applications to treat ischemic pathologies, however the exact nature of any protective effects are unclear at present. We therefore investigated the potential role of HBOT in modulating the ischemia/reperfusion (I/R) injury response in intestinal model of I/R injury. METHODS: Male Wistar rats were subjected to surgery for the induction of intestinal ischemia followed by reperfusion. HBOT was provided before and/or after intestinal ischemia. Cell viability in the intestinal tissue was assessed using the MTT assay and by measuring serum malondealdehyde (MDA). Microvascular density and apoptosis were evaluated by immunohistochemistry. RESULTS: The results indicate that HBOT treatment pre- and post-ischemia reduces lesion size to the intestinal tissue. This treatment increases cell viability and reduces the activation of caspase-3, which is associated with increased number of tissue CD34 cells and enhanced VEGF expression. CONCLUSION: The hyperbaric oxygen therapy can limit tissue damage due to ischemia/reperfusion injury, by inducing reparative signaling pathways.
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Damulin, Igor’ V. "The use of hyperbaric oxygenation in neurological practice." Medical Journal of the Russian Federation 27, no. 4 (July 15, 2021): 385–93. http://dx.doi.org/10.17816/0869-2106-2021-27-4-385-393.
Повний текст джерелаАнотація:
Hyperbaric oxygenation (HBO) is traditionally considered a widespread additional method of therapy for various diseases that are associated with impaired tissue metabolism. Its use in neurological diseases of various origins is based on the significance of cerebral hypoxia as one of the leading pathogenetic factors. HBO increases blood oxygenation, which intensifies redox processes in tissues, improves cellular metabolism, decreases cerebral edema and intracranial pressure, and, ultimately, improves treatment results for neurological diseases of various pathogenesis. The use of HBO can form highly active oxygen compounds, some of which have antiviral activity. Therefore, taking the increased tissue oxygenation into account, HBO is considered a very promising treatment method for patients with coronavirus disease-2019.
HBO is recommended for carbon monoxide poisoning, stroke and poststroke disorders, dementia (including vascular dementia), and craniocerebral injury, as well as in craniocerebral injury consequences and benign intracranial hypertension. The results of using this method for headaches of vascular origin, polyneuropathies of various origins (including diabetic polyneuropathy), multiple sclerosis, and infantile cerebral palsy are less conclusive.
The existing contradictory opinions regarding the HBO protocol and the indications for the use of this treatment method require further research in this field.
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Siewiera, Jacek, Przemysław Szałański, Dariusz Tomaszewski, and Jacek Kot. "High-Altitude Decompression Sickness Treated with Hyperbaric Therapy and Extracorporeal Oxygenation." Aerospace Medicine and Human Performance 91, no. 2 (February 1, 2020): 106–9. http://dx.doi.org/10.3357/amhp.5457.2020.
Повний текст джерелаАнотація:
BACKGROUND: High-altitude decompression sickness (HADCS) is a rare condition that has been associated with aircraft accidents. To the best of our knowledge, the present paper is the first case report of a patient treated for severe HADCS using recompression therapy and veno-venous extracorporeal oxygenation (VV-ECMO) with a complete recovery.CASE REPORT: After depressurization of a cabin, the 51-yr-old jet pilot was admitted to the Military Institute of Medicine with a life-threatening HADCS approximately 6 h after landing from a high-altitude flight, in a dynamically deteriorating condition, with progressing dyspnea and edema, reporting increasing limb paresthesia, fluctuating consciousness, and right-sided paresis. Hyperbaric oxygen therapy in the intensive care mode was initiated. A therapeutic recompression with U.S. Navy Treatment Table 6 was performed with neurological improvement. Due to cardiovascular collapse, sedation, mechanical ventilation, and significant doses of catecholamines were started, followed by continuous veno-venous hemodialysis. In the face of disturbances in oxygenation, during the second day of treatment the patient was commenced on veno-venous extracorporeal oxygenation. Over the next 6 d, the patient’s condition slowly improved. On day 7, VV-ECMO was discontinued. On day 19, the patient was discharged with no neurological deficits.DISCUSSION: We observed two distinct stages during the acute phase of the disease. During the first stage, signs of hypoperfusion, neurological symptoms, and marbled skin were observed. During the second stage, multiple organ dysfunction dominated, including heart failure, pulmonary edema, acute kidney injury, and fluid overload, all of which can be attributed to extensive endothelial damage.Siewiera J, Szałański P, Tomaszewski D, Kot J. High-altitude decompression sickness treated with hyperbaric therapy and extracorporeal oxygenation. Aerosp Med Hum Perform. 2020; 91(2):106–109.
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Siewiera, Jacek, Klaudia Brodaczewska, Natalia Jermakow, Arkadiusz Lubas, Krzysztof Kłos, Aleksandra Majewska, and Jacek Kot. "Effectiveness of Hyperbaric Oxygen Therapy in SARS-CoV-2 Pneumonia: The Primary Results of a Randomised Clinical Trial." Journal of Clinical Medicine 12, no. 1 (December 20, 2022): 8. http://dx.doi.org/10.3390/jcm12010008.
Повний текст джерелаАнотація:
Mortality in COVID-19 is mainly associated with respiratory failure, cytokine storm, and macrophage activation. Oxygenation and anti-inflammatory effects of Hyperbaric Oxygen Therapy (HBOT) suggest that it is a promising adjunct treatment for COVID-19. Repeated sessions of HBO with standard COVID-19 therapy were used to reduce the inflammation and increase oxygenation. We evaluated the safety and efficacy of HBOT in avoiding the replacement ventilation and/or ECMO and its effect on the inflammatory process. Twenty-eight moderate-to-severe COVID-19 patients were randomized into control or HBOT group. HBOT patients participated in 5 hyperbaric sessions (60 min). Before and after each session blood gas levels and vital parameters were monitored. Blood samples were collected for extended biochemical tests, blood morphology and immunological assays. There were 3 deaths in the control, no deaths in the HBOT group. No adverse events leading to discontinuation of HBOT were observed and patients receiving HBOT required lower oxygen delivery. We observed decrease in CRP, ferritin and LDH and increase in CD3 in HBOT group compared to control. This study confirmed the feasibility and safety of HBOT in patients with COVID-19 and indicated HBOT can lead to alleviation of inflammation and partial restoration of T cell responses.
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Widiyanti, Prihartini. "The Role of Hyperbaric Oxygen to Platelet Aggregation in Diabetic Patients Type II (NIDDM)." Indonesian Journal of Tropical and Infectious Disease 1, no. 2 (May 3, 2010): 77. http://dx.doi.org/10.20473/ijtid.v1i2.2170.
Повний текст джерелаАнотація:
Prevalency of Diabetes Mellitus in Indonesia has tendency to be increased from year to year. Hyperbaric Oxygenation (HBO) has been used as treatment of Diabetes Mellitus's complication especially diabetic gangrene. But the effect of HBO to the rheology's disfunction especially platelet's aggregation in the patients of NIDDM was investigated. The randomized pretest-posttest design was used in this study. An experimental laboratory study was performed at Naval Health Institution in Surabaya. 32 patients of NIDDM,women, 40–75 years old, normal physic's diagnosa, normal thorak's photo, normal EKG, normal Ear Nose and Throat, Diabetes Mellitus's family's record, normal weight (BMI), blood glucose level didn't exceed 400 mg/dl (including controlled DM FBG < 120 mg/dl dan 2 H BG < 160 mg/dl), NIDDM, normal level of HbA1c (4–5,9), as long as this research they couldn’t take their Oral Hipoglikemic Agent, Oral Anti Trombotic, vitamin C and vitamin E. They are divided into 2 group: group of HBO 100% O 2,4 ATA for 3x30 minutes with interval 5 minutes to inhalate air once a day daily for 5 days subsequently and the extraction of data (PAT) had been held before oxygenation hyperbaric therapy at the first day and the end of fifth days, in control group only giving 20% O2 with the pressure 1 ATA for 90 minutes once a day daily for 5 days subsequently and the extraction of data (PAT) had been held before normoxia normobaric therapy at the first day and the end of fifth days. The results were significant decrease of the platelet’s aggregation level especially percent of aggregation after 5 days from 76,56 ± 8,06 become 69,13 ± 6,03. Latent Periode has also decrease from 28,75 ± 3,87 become 25,75 ± 2,82. Speed of Aggregation has also decrease from 66,25 ± 3,17 become 62,50 ± 3,44. Index of Aggregation has also decrease from 0,763 ± 0,071 become 0,581 ± 0,083. Using paired t-test, it could be seen the decrease of Latent Periode (p= 0,001) and index of aggregation (p= 0,000) significantly after exposure of oxygenation hyperbaric HBO 2,4 ATA 100% O 3×30 minutes with interval 5 minutes inhalate air once a day for 5 days,subsequently. Speed of aggregation (p = 0,022) and percent of aggregation (p= 0,013) are nonsignificantly. The conclusion of this research is that oxygenation hyperbaric 2,4 ATA 100% O2 3×30 minutes with interval 5 minutes inhalate air once a day for 5 days,subsequently could decrease latent periode, speed of aggregation, index of aggregation and percent of aggregation in NIDDM
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Rosa, Isabel, and Francisco Guerreiro. "Hyperbaric Oxygen Therapy for the Treatment of Fournier’s Gangrene: A Review of 34 Cases." Acta Médica Portuguesa 28, no. 5 (September 17, 2015): 619. http://dx.doi.org/10.20344/amp.6300.
Повний текст джерелаАнотація:
<p><strong>Introduction:</strong> Fournier’s gangrene is a serious necrotizing infection that can be fatal if not promptly attended. Treatment for this condition consists of a combination of surgical debridement, antibiotherapy and supportive care. Hyperbaric oxygen therapy is used as an adjuvant for the optimization of infected tissue oxygenation and for its bactericidal and bacteriostatic effects.<br /><strong>Material and Methods:</strong> The data presented in this study encompass a period of 25 years of clinical records of patients with Fournier’s gangrene that had been treated at our center with hyperbaric oxygen therapy.<br /><strong>Results:</strong> A total of 34 patients were treated. The vast majority of patients were males (94.1%) with a mean age of 53.7 years. Urinary tract was the most frequent source of infection and diabetes was most common comorbidity seen in patients. Mortality rate was 20.8%.<br /><strong>Discussion:</strong> The most common observed comorbidity was diabetes, suggesting diabetes as one predisposing factor. The majority of deceased patients had diabetes, although no significant correlation between diabetes and death was found. The area of residence of patients may affect patients’ referral to these facilities.<br /><strong>Conclusions:</strong> Although Fournier’s gangrene is a rare condition, it is nevertheless a fatal illness, namely in patients with comorbidities like diabetes. Hyperbaric oxygen therapy is recommended as an adjuvant to conventional therapy and should be considered whenever available. To further assess the role of hyperbaric oxygen therapy, in the treatment of this condition, additional studies should be carried out.</p>
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Tejada, Silvia, Juan M. Batle, Miguel D. Ferrer, Carla Busquets-Cortés, Margalida Monserrat-Mesquida, Seyed M. Nabavi, Maria del Mar Bibiloni, Antoni Pons, and Antoni Sureda. "Therapeutic Effects of Hyperbaric Oxygen in the Process of Wound Healing." Current Pharmaceutical Design 25, no. 15 (August 19, 2019): 1682–93. http://dx.doi.org/10.2174/1381612825666190703162648.
Повний текст джерелаАнотація:
Chronic and non-healing wounds, especially diabetic foot ulcers and radiation injuries, imply remarkable morbidity with a significant effect on the quality of life and a high sanitary cost. The management of these wounds requires complex actions such as surgical debris, antibiotic treatment, dressings and even revascularization. These wounds are characterized by poor oxygen supply resulting in inadequate oxygenation of the affected tissue. The adjuvant treatment with hyperbaric oxygen therapy (HBOT) may increase tissue oxygenation favoring the healing of wounds which do not respond to the usual clinical care. The increase in the partial pressure of oxygen contributes to cover the energy demands necessary for the healing process and reduces the incidence of infections. Moreover, the increase in oxygen leads to the production of reactive species with hormetic activity, acting on signaling pathways that modulate the synthesis of inflammation mediators, antioxidants and growth factors which can contribute to the healing process. Studies performed with cell cultures and in animal models seem to demonstrate the beneficial effects of HBOT. However, clinical trials do not show such conclusive results; thus, additional randomized placebo-controlled studies are necessary to determine the real efficacy of HBOT and the mechanism of action for various types of wounds.
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Chen, Wan, Xingmei Liang, Zhihuan Nong, Yaoxuan Li, Xiaorong Pan, Chunxia Chen, and Luying Huang. "The Multiple Applications and Possible Mechanisms of the Hyperbaric Oxygenation Therapy." Medicinal Chemistry 15, no. 5 (July 2, 2019): 459–71. http://dx.doi.org/10.2174/1573406415666181219101328.
Повний текст джерелаАнотація:
Hyperbaric Oxygenation Therapy (HBOT) is used as an adjunctive method for multiple diseases. The method meets the routine treating and is non-invasive, as well as provides 100% pure oxygen (O2), which is at above-normal atmospheric pressure in a specialized chamber. It is well known that in the condition of O2 deficiency, it will induce a series of adverse events. In order to prevent the injury induced by anoxia, the capability of offering pressurized O2 by HBOT seems involuntary and significant. In recent years, HBOT displays particular therapeutic efficacy in some degree, and it is thought to be beneficial to the conditions of angiogenesis, tissue ischemia and hypoxia, nerve system disease, diabetic complications, malignancies, Carbon monoxide (CO) poisoning and chronic radiation-induced injury. Single and combination HBOT are both applied in previous studies, and the manuscript is to review the current applications and possible mechanisms of HBOT. The applicability and validity of HBOT for clinical treatment remain controversial, even though it is regarded as an adjunct to conventional medical treatment with many other clinical benefits. There also exists a negative side effect of accepting pressurized O2, such as oxidative stress injury, DNA damage, cellular metabolic, activating of coagulation, endothelial dysfunction, acute neurotoxicity and pulmonary toxicity. Then it is imperative to comprehensively consider the advantages and disadvantages of HBOT in order to obtain a satisfying therapeutic outcome.
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Olszański, Romuald, Maciej Konarski, and Piotr Siermontowski. "Hyperbaric Oxygen Therapy (HBOT) as a Therapeutic Option for Patients with Atopic Dermatitis (AD) – Own Experiences and Literature Review." Polish Hyperbaric Research 60, no. 3 (October 26, 2017): 13–18. http://dx.doi.org/10.1515/phr-2017-0012.
Повний текст джерелаАнотація:
Abstract The paper discusses the treatment results of ten patients with severe atopic dermatitis (AD) who did not respond to standard pharmacotherapy and underwent hyperbaric oxygen therapy (HBOT). Each patient was subject to 10 oxygen exposures at pO2 2.5 ATA (~ 250 kPa) with the duration time of 60 minutes. In the period of implementation of the hyperbaric procedures the general treatment plan was suspended for all patients while maintaining typical local treatment. Clinical evaluation was performed in the study group as well as determination of levels of immunoglobulins: IgA, IgG, IgM and IgE and C3 and C4 complement. All patients indicated clinical improvement and a decreased IgE immunoglobulin and complement C3 level upon the completion of the exposure cycle. Taking into account the authors’ own observations and data from literature, an overall improvement in the clinical status and a decrease in the level of immunoglobulin E and C3 complement following a cycle of exposures may be indicative of an immunomodulating HBOT effect on AD, whereas hyperbaric oxygenation may constitute a therapeutic option for some patients with AD, especially those exhibiting a poor response to standard treatment.
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Stefanovic, Zvezdan, Branislav Donfrid, Tomislav Jovanovic, Zoran Zoric, Radmila Radojevic-Popovic, and Uros Zoranovic. "Hyperbaric oxygenation in prevention of amputations of diabetic foot." Vojnosanitetski pregled 77, no. 4 (2020): 363–72. http://dx.doi.org/10.2298/vsp180220081s.
Повний текст джерелаАнотація:
Background/Aim. Diabetic foot is the term for the pathological changes on foot in patients with diabetes. It is caused by diabetic angiopathy, polyneuropathy and osteoarthropathy. The treatment is complex and long-term and often leads to the loss of the extremity. The appliance of hyperbaric oxygen therapy (HBOT) has a lot more important place in adjuvant treatment of this disease. The aim of this study was to determine the influence of HBOT on the wound healing in comparison with the conventional treatment, the possibility of shortening the time of the treatment in patients with diabetic foot. Methods. In a fiveyear period a retrospective-prospective multicentric study, involving 60 patients with diabetic foot divided into two groups, was performed. The first group (group A) consisted of 30 patients treated by combined therapy (with medications, surgical therapy and HBOT). All the patients were receiving HBOT in the Special Hospital for Hyperbaric Medicine, CHM Hollywell-Neopren in Belgrade. The control group (group B) also consisted of 30 patients treated with medications and surgical therapy, but without HBOT. Results. The demographic data, the types of diabetes, as well as the Wagner classification stage of diabetic ulcers and radiography scans of changes in bones were equal in both groups. The median healing time of the Wagner grade III ulcer in the group A was 37.36 days [mean ? standard deviation (SD) = 65.6 ? 45.8 days], and in the group B 99.78 days (mean ? SD = 134.8 ? 105.96 days) and it was statistically significant (p = 0.074). The median time of recovery in patients of the group A with the Wagner grade IV was 48.18 days (mean ? SD = 49.7 ? 33.8 days), and in the group B 85.05 days (mean ? SD = 86.7 ? 71.6 days) and that was statistically significant (p = 0.121). The foot amputations were performed in both groups in 3 (10%) patients. In the group A there were no high amputations, whereas in the group B there were 4 (13.33%) below-knee amputations and 4 (13.33%) above-knee amputations which was highly statistically significant (p < 0.0001). Conclusion. In this study, HBOT definitely showed positive adjuvant role in the treatment of diabetic foot. For the good treatment result it is essential the timely and successful surgical treatment of the ulcer and the use of bandage with the healing dressings. In case of the clear signs of local infection, the antibiotic therapy according to the antibiogram is necessary.
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Popovicheva, Alexandra, Andrew Martusevich, and Elvira Fedulova. "FUNCTIONAL PROPERTIES OF PLATELET IN CHILDREN WITH IRRITABLE BOWEL DISEASE." Archiv Euromedica 11, no. 2 (June 27, 2021): 80–81. http://dx.doi.org/10.35630/2199-885x/2021/11/2/20.
Повний текст джерелаАнотація:
The aim of the study was to evaluate platelet activation and aggregation in children with irritable bowel disease (IBD), as well as the effect of hyperbaric oxygenation on these processes. Platelet activation and aggregation in artificial shear flow were studied in 120 patients of both sexes aged 6 to 17 years with IBD. In pediatric patients with CD and UC, a significant increase in the activation and aggregation of platelets was revealed under shear flow conditions. The use of hyperbaric oxygen therapy leads to a decrease in the studied processes. It was found that IBD in children is characterized by significant changes in the functional properties of platelets (activation and aggregation processes).
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Brahmanta, Arya, Sutjipto Sutjipto, and Ida Bagus Narmada. "Histological changes during orthodontic tooth movement due to hyperbaric oxygen therapy." Dental Journal (Majalah Kedokteran Gigi) 49, no. 2 (February 14, 2017): 63. http://dx.doi.org/10.20473/j.djmkg.v49.i2.p63-66.
Повний текст джерелаАнотація:
Background: Mechanical force of orthodontics causes changes in periodontal ligament vascularization and blood flow, resulting in biochemical and cellular changes as well as changes in the contour of the alveolar bone and in the thickness of the periodontal ligaments. Hyperbaric oxygen (HBO) therapy is one of many solutions stimulating the growth of new blood vessels and increasing tissue oxygenation. Thus, HBO plays a role in recovery of periodontal ligament and osteoblasts. Purpose: This study aimed to determine the effects of HBO therapy for seven days on periodontal ligament size and osteoblast number in the tension site during bone remodeling in tooth movement. Method: The study was true experimental laboratories with completely randomized control group post test only design. Twenty-four males guinea pigs were randomly divided into three groups. K0 was the control group without any treatment, K1 was the group given a mechanical orthodontic pressure, and K2 was the group treated with the addition of hyperbaric oxygen therapy. The maxillary incisors were moved distally by elastic separator. After HBO therapy on day 7, all of the groups were sacrificed, and then periodontal ligament size and osteoblast number were analyzed by one-way Anova and LSD statistical tests. Result: The results showed significant differences in the size of the periodontal ligament and the number of osteoblasts in the tension site among the groups (p<0.05). Conclusion: HBO therapy at 2.4 ATA for 7 days is effective in recovery of periodontal ligament and increased osteoblast number during bone remodeling in tension area of orthodontic tooth movement.
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Rockswold, Sarah B., Gaylan L. Rockswold, Janet M. Vargo, Carla A. Erickson, Richard L. Sutton, Thomas A. Bergman, and Michelle H. Biros. "Effects of hyperbaric oxygenation therapy on cerebral metabolism and intracranial pressure in severely brain injured patients." Journal of Neurosurgery 94, no. 3 (March 2001): 403–11. http://dx.doi.org/10.3171/jns.2001.94.3.0403.
Повний текст джерелаАнотація:
Object. Hyperbaric oxygenation (HBO) therapy has been shown to reduce mortality by 50% in a prospective randomized trial of severely brain injured patients conducted at the authors' institution. The purpose of the present study was to determine the effects of HBO on cerebral blood flow (CBF), cerebral metabolism, and intracranial pressure (ICP), and to determine the optimal HBO treatment paradigm. Methods. Oxygen (100% O2, 1.5 atm absolute) was delivered to 37 patients in a hyperbaric chamber for 60 minutes every 24 hours (maximum of seven treatments/patient). Cerebral blood flow, arteriovenous oxygen difference (AVDO2), cerebral metabolic rate of oxygen (CMRO2), ventricular cerebrospinal fluid (CSF) lactate, and ICP values were obtained 1 hour before and 1 hour and 6 hours after a session in an HBO chamber. Patients were assigned to one of three categories according to whether they had reduced, normal, or raised CBF before HBO. In patients in whom CBF levels were reduced before HBO sessions, both CBF and CMRO2 levels were raised 1 hour and 6 hours after HBO (p < 0.05). In patients in whom CBF levels were normal before HBO sessions, both CBF and CMRO2 levels were increased at 1 hour (p < 0.05), but were decreased by 6 hours after HBO. Cerebral blood flow was reduced 1 hour and 6 hours after HBO (p < 0.05), but CMRO2 was unchanged in patients who had exhibited a raised CBF before an HBO session. In all patients AVDO2 remained constant both before and after HBO. Levels of CSF lactate were consistently decreased 1 hour and 6 hours after HBO, regardless of the patient's CBF category before undergoing HBO (p < 0.05). Intracranial pressure values higher than 15 mm Hg before HBO were decreased 1 hour and 6 hours after HBO (p < 0.05). The effects of each HBO treatment did not last until the next session in the hyperbaric chamber. Conclusions. The increased CMRO2 and decreased CSF lactate levels after treatment indicate that HBO may improve aerobic metabolism in severely brain injured patients. This is the first study to demonstrate a prolonged effect of HBO treatment on CBF and cerebral metabolism. On the basis of their data the authors assert that shorter, more frequent exposure to HBO may optimize treatment.
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Kukshina, A. A., A. V. Kotelnikova, E. A. Turova, A. M. Schikota, and D. I. Tagirova. "Hyperbaric Oxygenation in the Muilimodality Therapy of COVID-19-Associated Emotional Burnout in Physicians." Doctor.Ru 21, no. 4 (2022): 47–52. http://dx.doi.org/10.31550/1727-2378-2022-21-4-47-52.
Повний текст джерелаАнотація:
Study Objective: To assess the efficacy of adding hyperbaric oxygenation (HBO) in Oxysys 4500 oxygen cabinet to a set of rehabilitative measures in healthcare professionals with emotional burnout syndrome (EBS). Study Design: Open-label prospective randomized comparative cohort study. Materials and Methods. We have examined 79 healthcare professionals who experienced stress during the COVID-19 pandemic. We have studied changes in the psychoemotional state of subjects during rehabilitation that included HBO procedures in Oxysys 4500. We used Beck’s depression test, State-Trait Anxiety Inventory, and methods for professional burnout diagnostics developed by C. Maslach and S. Jackson. Study Results. EBS and psychoemotional consequences of the stress were observed in two-thirds of respondents, predominantly in young persons, and were more often (р ≤ 0,05) recorded in subjects who did not have COVID-19. The contribution of the stress and state anxiety in the formation of EBS symptoms allows making them a target for psychoemotional stabilisation and elimination of consequences of the occupational stress. Addition of HBO sessions to the therapy resulted in reduction in depression and reduced state anxiety. Conclusion. The high efficacy of HBO addition to rehabilitation of healthcare professionals with EBS has been demonstrated. Keywords: emotional burnout syndrome, hyperbaric oxygenation, COVID-19.
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Maran, Cristiane Antequeira, and Sergio Xavier Salles-Cunha. "Common femoral artery doppler findings pre and post hyperbaric oxygen therapy for leg ulceration." Revista Baiana de Saúde Pública 45 (December 27, 2021): 39–47. http://dx.doi.org/10.22278/2318-2660.2021.v45.nsupl_2.a3556.
Повний текст джерелаАнотація:
Hyperbaric Oxygen Therapy (HBOT) assumes that high pressure hyperoxygenation causes faster tissue recovery and wound healing. Lower extremity flow rates are affected by leg ulcers that change vasodilation, microcirculation resistance, and local tissue demands; how blood hyper oxygenation influences these factors is still unclear. Peripheral arterial occlusive disease (PAOD) has been mostly associated with HBOT results in the femoral artery than in other arteries. Common femoral artery (CFA) peak systolic velocities (PSV), measured pre and post HBOT, were analyzed to research HBOT hemodynamics. Sixteen patients with leg ulcers who were 65 ± 11 (SD) (38-87) years-old, had HBOT of 90 minutes at 2.6 ATA. Bilateral CFA Doppler velocity waveforms were recorded immediately pre and post HBOT. Ulcerated vs non-ulcerated peak systolic velocity (PSV) data were compared using paired t-test. CFA PSV were significantly equal in the ulcerated and non-ulcerated extremities before HBOT: 114 ± 35 (SD) cm/s vs 116 ± 41 cm/s (p = 0.87 by paired t-test). CFA PSV in the ulcerated extremity increased to 122 ± 35 cm/s after HBOT but were statistically insignificant (p =.19 by one-tailed paired t-test). On the other hand, CFA PSV decreased to 103 ± 28 cm/s (p =.049 by one-tailed paired t-test) in the non-ulcerated extremity and were significantly lower after HBOT, with 103 ± 28 cm/s vs 122 ± 35 cm/s for the ulcerated limb (p =.02 by paired t-test). Blood velocity responses post HBOT showed differences between ulcerated vs non-ulcerated extremities. The non-ulcerated extremity apparently responded to oxygenation more than the ulcerated extremity. Such observation suggests further research on hemodynamic reactions caused by HBOT.
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Williams, Simon TB. "Chronic Regional Pain Syndrome After Subtalar Arthrodesis Is Not Prevented by Early Hyperbaric Oxygen." September 2009 5;12, no. 5;9 (July 14, 2009): E335—E339. http://dx.doi.org/10.36076/ppj.2009/12/e335.
Повний текст джерелаАнотація:
Subtalar arthrodesis was performed on a 48-year-old, non-insulin-dependent diabetic with a history of chronic ankle instability and lateral ankle pain. In the early post-operative period he presented as an emergency with an infection at the operative site. This was treated with 2 returns to the operating theatre for washout and debridement. His wounds were left open and at 3 weeks after emergency admission he was referred for adjunctive hyperbaric oxygen (HBO) therapy to aid healing by secondary intention. He received a total of 19 hyperbaric sessions, at a pressure of 2.2 ATA, one treatment per day for 5 days a week. Shortly after commencing HBO therapy his ankle became increasingly painful, despite the introduction of analgesia. By 7 weeks after emergency admission his wounds had virtually healed but hyperesthesia persisted over the dorsum of the foot. A computerized tomography scan at 5½ months post-operatively showed satisfactory joint fusion and revealed no evidence of infection. Symptoms and signs at this time were compatible with a diagnosis of chronic regional pain syndrome (CRPS). There is published evidence to suggest that HBO therapy may be a useful modality in the treatment of established CRPS. Here, we seek to publicize a case in which early treatment with HBO for another indication did not prevent the simultaneous development of CRPS Type 1. Key words: Subtalar arthrodesis, hyperbaric oxygenation, chronic regional pain syndrome
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Tannheimer, Markus, and Raimund Lechner. "Initial Treatment of High-Altitude Pulmonary Edema: Comparison of Oxygen and Auto-PEEP." International Journal of Environmental Research and Public Health 19, no. 23 (December 3, 2022): 16185. http://dx.doi.org/10.3390/ijerph192316185.
Повний текст джерелаАнотація:
Background: Improvement of oxygenation is the aim in the therapy of high-altitude pulmonary edema (HAPE). However, descent is often difficult and hyperbaric chambers, as well as bottled oxygen, are often not available. We compare Auto-PEEP (AP-Pat), a special kind of pursed lips breathing, against the application of bottled oxygen (O2-Pat) in two patients suffering from HAPE. Methods: We compare the effect of these two different therapies on oxygen saturation measured by pulse oximetry (SpO2) over time. Result: In both patients SpO2 increased significantly from 65–70% to 95%. Above 80% this increase was slower in AP-Pat compared with O2-Pat. Therapy started immediately in AP-Pat but was delayed in O2-Pat because of organizational and logistic reasons. Conclusions: The well-established therapies of HAPE are always the option of choice, if available, and should be started as soon as possible. The advantage of Auto-PEEP is its all-time availability. It improves SpO2 nearly as well as 3 L/min oxygen and furthermore has a positive effect on oxygenation lasting for approximately 120 min after stopping. Auto-PEEP treatment does not appear inferior to oxygen treatment, at least in this cross-case comparison. Its immediate application after diagnosis probably plays an important role here.
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Zivaljevic, Zvonko, Ljubica Zivic, Natasa Mihailovic, Miodrag Zivkovic, Branko Vorkapic, and Nenad Baletic. "Treatment of sudden sensorineural hearing loss with hyperbaric oxygenation - our experience." Vojnosanitetski pregled 74, no. 2 (2017): 156–60. http://dx.doi.org/10.2298/vsp150529168z.
Повний текст джерелаАнотація:
Background/Aim. Sudden sensorineural hearing loss is manifested by the loss of hearing for more than 30 dB at three consecutive frequencies in the timeframe of 72 h. It is of unclear etiology and pathogenesis, which leads to the use of different therapeutic methods. Treatment protocols are not compliant, making it difficult to objectively quantify their impact. The aim of this study was to show the effect of hyperbaric oxygen therapy as the only method for the treatment of sudden sensorineural hearing loss. Methods. This retrospective study included 20 patients treated for sudden sensorineural hearing loss with hyperbaric oxygenation (HBO) in the period from 2004 to 2014. The study was conducted in the specialized medical clinic for hyperbaric and underwater medicine, HBO Medical Center in Belgrade. The patients were treated according to the following protocol: a session of 60 min at the pressure of 2 bars (2ATA) two times a day, a total of 30 sessions. Assessment of the therapy effects was performed by observing the change in the hearing threshold at the frequencies of 500, 1,000, 2,000 and 4,000 Hz at the end of the treatment. Results. After the completion of treatment according to the protocol, a full hearing recovery (total improvement of hearing damage or achieving final hearing threshold above 25 dB) was found in 11 (55%) of the patients. A partial recovery (hearing improvement of up to 15 dB, and a final hearing threshold below 45 dB) occurred in 4 (20%) of the patients. In 5 (25%) of the patients, improvement was not verified (there was no recovery or it was less than 5 dB). The average absolute hearing recovery was 24.94 dB. The mean relative hearing recovery was 65.45%. Conclusion. Because of the unclear multifactorial etiopathogenesis of this disease, there are many therapeutic protocols. Based on the results of our study HBO therapy could be recommended primarily as the treatment for sudden sensorineural hearing loss.
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Olex-Zarychta, Dorota. "Hyperbaric Oxygenation as Adjunctive Therapy in the Treatment of Sudden Sensorineural Hearing Loss." International Journal of Molecular Sciences 21, no. 22 (November 14, 2020): 8588. http://dx.doi.org/10.3390/ijms21228588.
Повний текст джерелаАнотація:
Sudden sensorineural hearing loss seems to become a serious social health problem in modern societies. According to the World Health Organization (WHO) reports, adult-onset sensorineural hearing loss is found to be one of the leading diseases at the global level, especially in high-income countries, and is foreseen to move up from the 14th to 7th leading cause of the global burden of diseases by the year 2030. Although the direct mortality rate of this disease is very low, its influence on quality of life is huge; that is the reason why the implementation of the most effective and the safest therapies for the patient is crucial for minimizing the risk of complications and adverse reactions to treatment. The aim of this paper is to present hyperbaric oxygen therapy (HBOT) as a medical procedure useful in the treatment of sudden sensorineural hearing loss as adjunctive therapy of high efficacy. This paper focuses on the molecular mechanisms of action and clinical effectiveness of HBOT in the treatment of idiopathic sudden deafness, taking into consideration both the benefits and potential risks of its implementation.
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Ulewicz, Kazimierz, Przemysław Michniewski, Brunon Kierznikowicz, Bogdan Łokucijewski, and Jan Stencel. "Initial Tests on Selected Serological Reactions in Rabbits Burnt with Napalm and Subjected to Hyperbaric Oxygenation." Polish Hyperbaric Research 50, no. 1 (March 1, 2015): 41–45. http://dx.doi.org/10.1515/phr-2015-0005.
Повний текст джерелаАнотація:
Abstract Hyperbaric oxygenation therapy has found its application in the treatment of various types of burns. The presented work describes the use of this method in treating napalm burns in experimental animals. The researchers took particular interest in the immunological reactions occurring in animals, as well as the effect of the said therapy on the healing process. Two groups of rabbits, previously anaesthetised with Evipan and immunised with S. typhi phage F7 microorganisms, were burnt with the use of napalm. The tested group was subjected to a series of treatment sessions with 100% oxygen at the pressure of 2 atm, whereas the control group did not undergo such treatment. Six repeated tests on complement activity with 50% haemolysis method and heamagglutination reaction quantification with antigens O and H S.typhi phage F7 were carried out on all of the researched animals. Moreover, for the purpose of control of the healing process, a number of histopathological exams on the burn wounds were conducted in both groups of rabbits. The research showed an increase in complement activity in all tested animals; however, in the tested group it occurred later. Histopathological tests confirmed a more advanced healing process in the group subjected to hyperbaric oxygenation.
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Siewiera, Jacek, Michał Smoleński, Natalia Jermakow, Jacek Kot, Klaudia Brodaczewska, Jacek Turyn, Magdalena A. Zabielska-Kaczorowska, Nils Ludwig, and Mirosław J. Szczepański. "Effect of Hyperbaric Oxygenation on Blood Cytokines and Arginine Derivatives; No Evidence for Induction of Inflammation or Endothelial Injury." Journal of Clinical Medicine 10, no. 23 (November 23, 2021): 5488. http://dx.doi.org/10.3390/jcm10235488.
Повний текст джерелаАнотація:
(1) Background: Hyperbaric oxygen therapy (HBOT) uses 100% oxygen delivered at 1.5–3 times the atmospheric pressure in a specialised chamber to achieve supraphysiological oxygen tension in blood and tissues. Besides its target, HBOT may affect inflammation, endothelial function or angiogenesis. This study analysed the effect of HBOT on blood concentrations of factors that may affect these processes in patients with necrotizing soft-tissue infections (NSTI), aseptic bone necrosis (ABN) and idiopathic sudden sensory neural hearing loss (ISSNHL). (2) Methods: Concentrations asymmetric dimethylarginine (ADMA) and other arginine derivatives were measured with liquid chromatography/mass spectrometry, whereas ELISA was used to quantitate vascular endothelial growth factor (VEGF) and cytokines (IL-1, IL-4, IL-6, IL-10, TGF-β) before and after HBOT in 80 patients (NSTI n = 21, ISSNHL n = 53, ABN n = 6). (3) Results: While some differences were noted between patient groups in ADMA and other arginine derivatives as well as in cytokine concentrations, HBOT did not affect any of these parameters. (4) Conclusions: While cytokines and arginine derivatives concentrations were modified by underlying pathology, hyperbaric oxygenation did not immediately modify it suggesting that it is neutral for inflammation and is not inducing endothelial injury.
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Doboszyński, Tadeusz, and Bogdan Łokucijewski. "The Effect of Hyperbaric Oxygen Therapy On the Level of Lipid Peroxides in Rat Brains." Polish Hyperbaric Research 58, no. 1 (March 1, 2017): 37–40. http://dx.doi.org/10.1515/phr-2017-0032.
Повний текст джерелаАнотація:
Abstract The problem of oxygen toxicity, and its effect on the nervous system, is an important topic with regard to the application of oxygen and breathing mixes in the pursuit of diving, as well as in the light of the striking synergy between the effects of oxygen and ionising radiation. Studies on the level of lipid peroxides were performed on rat brains. The animals were subjected to exhaustive physical strain in a pressure chamber and oxygen at the pressure between 0-3 atm for the period of 25-60 minutes. Parallel research was conducted on rested animals. Following the dissection, the brain was homogenised and the levels of lipid peroxides were determined using the Wollman method with TBA. In animals subjected to physical effort over the specified time, no deviations in the levels of lipid peroxides were observed in comparison to the control group. An increase in lipid peroxide level was noted in rats manifesting oxygen toxicity symptoms. On the basis of the above findings, the authors presume that the growth of lipid peroxides in the brain in cases subjected to hyperbaric oxygenation should be recognised as a far-reaching harmful effect of oxygen, occurring after enzymatic damage and the violation of cellular antioxidant protection. At low oxygen overpressures, no deviations in the levels of lipid peroxides were noted as compared to the control group.
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Choi, Sangchun, Hyuk-Hoon Kim, Seong Beom, and Yoon Seok Jung. "Repetitive hyperbaric oxygen therapy for paroxysmal sympathetic hyperactivity after acute carbon monoxide poisoning." Undersea and Hyperbaric Medicine 48, no. 4 (October 1, 2021): 4431–441. http://dx.doi.org/10.22462/07.08.2021.8.
Повний текст джерелаАнотація:
Delayed neuropsychological sequelae (DNS) are relatively common complications of acute carbon monoxide (CO)poisoning, and usually develop within several days to weeks after the initial clinical recovery from acute CO poisoning. DNS can consist of various symptoms such as memory loss, confusion, ataxia, seizures, urinary incontinence, fecal incontinence, emotional lability, disorientation, hallucinations, mutism, cortical blindness, psychosis, parkinsonism, gait disturbances, rigidity, bradykinesia, and other motor disturbances. Paroxysmal sympathetic hyperactivity (PSH) is a potentially life-threatening disease secondary to acute acquired brain injury. It is characterized by episodic and simultaneous paroxysmal increases in sympathetic and motor activities, not rare in patients with a severe traumatic brain injury. The term PSH is clinically more accurate than the previously used ones describing such conditions as non-stimulated tachycardia, hypertension, tachypnea, hyperthermia, external posturing, diaphoresis, and paroxysmal autonomic instability with dystonia. Development of PSH typically prolongs the length of hospital stay and potentially leads to a secondary brain injury or even death. To date, the occurrence of PSH in the DNS after acute CO poisoning has not been reported in the literature. Potential mechanisms underlying the development of DNS in the deep white matter of the brain are immune-related inflammation and vasodilatation. Repetitive hyperbaric oxygen therapy, combined with methylprednisolone administration, may inhibit DNS progression by inducing cerebral oxygenation, inhibiting inflammation, and reducing cerebral edema. Herein, we report three cases in which the patients recovered from the PSH as DNS after CO poisoning after receiving repetitive hyperbaric oxygen therapy.
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Oropallo, Alisha R., Thomas E. Serena, David G. Armstrong, and Mark Q. Niederauer. "Molecular Biomarkers of Oxygen Therapy in Patients with Diabetic Foot Ulcers." Biomolecules 11, no. 7 (June 22, 2021): 925. http://dx.doi.org/10.3390/biom11070925.
Повний текст джерелаАнотація:
Hyperbaric oxygen therapy (HBOT) and topical oxygen therapy (TOT) including continuous diffuse oxygen therapy (CDOT) are often utilized to enhance wound healing in patients with diabetic foot ulcerations. High pressure pure oxygen assists in the oxygenation of hypoxic wounds to increase perfusion. Although oxygen therapy provides wound healing benefits to some patients with diabetic foot ulcers, it is currently performed from clinical examination and imaging. Data suggest that oxygen therapy promotes wound healing via angiogenesis, the creation of new blood vessels. Molecular biomarkers relating to tissue inflammation, repair, and healing have been identified. Predictive biomarkers can be used to identify patients who will most likely benefit from this specialized treatment. In diabetic foot ulcerations, specifically, certain biomarkers have been linked to factors involving angiogenesis and inflammation, two crucial aspects of wound healing. In this review, the mechanism of how oxygen works in wound healing on a physiological basis, such as cell metabolism and growth factor signaling transduction is detailed. Additionally, observable clinical outcomes such as collagen formation, angiogenesis, respiratory burst and cell proliferation are described. The scientific evidence for the impact of oxygen on biomolecular pathways and its relationship to the outcomes in clinical research is discussed in this narrative review.