Дисертації з теми "Hyperbaric oxygenation; Oxygen therapy"
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1
Kunin, Wendy. "Hyperbaric oxygen therapy following arthroscopic meniscectomy surgery." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80308.
Повний текст джерелаАнотація:
This study investigated the effects of hyperbaric oxygen (HBO2) therapy following partial arthroscopic meniscectomy surgery on swelling, perceived pain, range of motion at the knee joint, isokinetic strength, and leg function. Subjects were 8 males and 1 female with an acute tear to the meniscus. Subjects were randomly assigned to either a control group (n = 5) or an HBO2 treatment group (n = 5). The HBO 2 group received 5 HBO2 treatments at 2.5 ATA for 90 minutes at 95% O2 beginning 24 hours post-operation. Both groups were tested pre-operation (day 0) and on days 1, 2, 3, 4, 5, 20, 35, and 50 post-surgery. No significant difference was found between groups for any of the dependant variables. The results indicated that the control and HBO2 groups responded in a similar pattern when assessed for swelling, perceived pain, range of motion at the knee joint, leg function and isokinetic strength.
2
McGavock, Jonathan M. "The effect of hyperbaric oxygen therapy on aerobic performance following fatigue." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0027/MQ50544.pdf.
Повний текст джерела
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Vudiniabola, Sunia. "Hyperbaric oxygen therapy for the treatment and prevention of osteoradionecrosis /." Title page, contents and summary only, 1997. http://web4.library.adelaide.edu.au/theses/09DM/09dmv986.pdf.
Повний текст джерела
4
Germain, Geneviève. "Effect of hyperbaric oxygen therapy on exercise-induced muscle injury." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29504.
Повний текст джерелаАнотація:
The purpose of this study was to examine the effects of HBO2 therapy on exercise-induced muscle damage. Subjects (n = 16 university student volunteers) were randomly divided into an experimental group that received HBO2 therapy and a control group that did not receive any treatments. HBO2 treatments consisted of 5 sessions of breathing 95% oxygen at 2.5 atm abs for 100 min. Temporary muscle soreness was created using a single-leg eccentric exercise task involving the quadriceps femoris. Over the next 14 days, measurements were obtained on muscle soreness, leg circumference, quadriceps peak torque, quadriceps average power, fatigue and plasma creative kinase. After eccentric exercise, plasma CK levels and perceived muscle soreness were elevated but were not different between HBO2 and control groups. HBO2 therapy did not alter leg circumference, quadriceps peak torque, average power or fatigue compared to the control group. The data indicated that five HBO2 treatments did not speed recovery following eccentric exercise that induced temporary muscle damage.
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Bennett, Michael Heywood Prince of Wales Clinical School UNSW. "The evidence basis of diving and hyperbaric medicine - a synthesis of the high level clinical evidence with meta-analysis." Awarded by:University of New South Wales. Prince of Wales Clinical School, 2006. http://handle.unsw.edu.au/1959.4/24243.
Повний текст джерелаАнотація:
Introduction: Hyperbaric oxygen therapy (HBOT) is the administration of 100% oxygen at pressures greater than 1 atmosphere. One recurrent criticism that has been made of this field is that treatment is based on little or no good clinical evidence. Aims: The primary objective of this thesis is to make a useful response to that criticism. I planned to collate all the available randomised evidence in the fields of diving and hyperbaric medicine, supply a critical appraisal of each paper, and synthesise that evidence in a series of systematic reviews with meta-analysis. I also intended to use a cost analysis of hyperbaric practice in our own facility to inform formal cost-effectiveness analysis using the estimates of effect generated by the individual meta-analyses. Methods: A comprehensive search strategy was used to identify all clinical RCTs involving the administration of hyperbaric breathing mixtures. Each trial was appraised using the software developed by the Oxford Centre for Evidence Based Medicine. Each critical appraisal was loaded onto a searchable web site at www.hboevidence.com. Each diagnostic category identified was considered for inclusion in a Cochrane systematic review and meta-analysis. Results: The database includes 130 critical appraisals covering 173 separate reports. The site has received more than 17,000 hits. There are 12 formal meta-analytical reviews and all have been accepted for publication in the Cochrane Database of Systematic Reviews at the time of writing. These form the basis of this thesis and include late radiation tissue injury, chronic wounds, acute hearing loss and tinnitus, multiple sclerosis and decompression illness. The meta-analyses in this thesis suggest there are several areas where HBOT is associated with improved clinical outcomes and that routine use is probably justified in some areas (e.g. radiation proctitis healing with HBOT: NNT 3, 95%CI 2 to 11). On the other hand, these analyses suggest there is most unlikely to be significant clinical benefit from the application of HBOT to patients currently referred for HBOT (e.g. multiple sclerosis). Conclusions: The randomised evidence for the use of HBOT is now significantly easier to access. Recommendations for therapy and future research directions can be made on the basis of these analyses.
6
Skelton, Deborah. "The effects of hyperbaric oxygen therapy on acute ankle sprains /." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31140.
Повний текст джерелаАнотація:
This study investigated the effects of hyperbaric oxygen (HBO) therapy on acute ankle injuries and determined if HBO therapy shortened time to recovery, decreased edema and pain, and increased range of motion and strength of the ankle. Subjects were randomly assigned to either an experimental (HBO) group (n = 4) or a control group (n = 4). All subjects received the same standardized physical therapy for lateral ankle sprains at the McGill Sport Medicine Clinic. The HBO group received 5 consecutive HBO treatments at 2.5 ATA for 90 minutes starting within 24 hours post injury. The control group received no HBO treatments. All subjects were evaluated by a physician within 24 hours of injury. All subjects suffered a second-degree lateral ankle sprain. Pain, range of motion, strength, volume displacement, and function were evaluated on the day of injury (Day 1), on Day 6 post injury, and on the day of return to play (Day RTP). There was no significant difference in time to return to play. However, the HBO group (25.5 +/- 11.6 days) did return 31% faster than the control group (36.8 +/- 19.4 days). There were no differences found between groups on the variables. There was a decrease in pain found over time (Day 1 was 57 mm, Day 6 was 18.5 mm, and Day RTP was 7 mm). The results of this study suggest that with treatment of HBO there is no effect on ankle sprains for return to play or improved function.
7
Allie, Dean Gerard. "An assessment of the viability of establishing a hyperbaric oxygen therapy facility in the Nelson Mandela Metropolitan Municipality area." Thesis, Nelson Mandela Metropolitan University, 2005. http://hdl.handle.net/10948/151.
Повний текст джерелаАнотація:
At present, the Eastern Cape is the only province in South Africa lacking a clinical hospital-based hyperbaric facility. East Cape Hyperbaric, to be situated at Greenacres Hospital in the Nelson Mandela Metropolitan, will offer the Eastern Cape community access to a world-class facility that will offer their patients Hyperbaric Oxygen Therapy and a Wound-Healing Facility. The objective of this study was to assess the viability of establishing a Hyperbaric Oxygen Therapy (HBOT) facility for the Nelson Mandela Metropolitan Municipality (NMMM), using sound business planning principles. A business plan precisely defines the business, identifies the goals, and serves as the firm's resume. A business plan will assist in allocating resources effectively, handle unforeseen complications, and assist in making sound business decisions. Because it provides specific and organized information about the company and how the company will repay borrowed money, a good business plan is a crucial part of business planning. In order to quantify the demand for a Hyperbaric Oxygen Therapy facility, a questionnaire was designed, in such a manner as to identify the current demand for a HBOT facility. The questionnaires were distributed to all medical practitioners within the NMMM by means of fax, e-mail and hand-delivery. Research conducted indicates that the results are promising enough to warrant the expedient creation of this business facility.
8
Liebich, Ingrid. "Hyperbaric oxygen therapy for children with cerebral palsy : Jebsen-Taylor test of hand function." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31117.
Повний текст джерелаАнотація:
Despite lack of scientific evidence, hyperbaric oxygen therapy (HBO2) has been used as a treatment for children with cerebral palsy (CP). Recently, a multi-centre randomised, double-blind, placebo-controlled trial assessed the efficacy of HBO2 therapy for children with CP. Using the same cohort, the purpose of this study was to examine the effectiveness of HBO2 therapy on hand function using the Jebsen-Taylor test. All children received 40 treatments over a 2-month period. HBO2 treatments were 60 minutes with 100% O2 at 1.75 atmospheres absolute (ATA). Placebo treatments were also 60 minutes with air (21% O2) at 1.3 ATA. Seventy-eight children with CP, aged 3--12 years completed pre and post hand function assessments. Hand function was evaluated using one quantitative measure (time) and three qualitative measures. There were no significant changes between baseline and follow-up tests for any of the measures, although both experimental and control groups improved ( p = 0.08) their total times for the Jebsen test. The HBO2 group improved by 54.5 seconds (8.8%) while the placebo group improved by 47.8 seconds (7.7%). The results indicate that HBO2 therapy did not enhance the hand function of children with CP.
9
Moolman, Francis Sean. "Oxygen carriers for a novel bio-artificial liver support system." Pretoria : [s.n.], 2003. http://upetd.up.ac.za/thesis/available/etd-09092004-162043.
Повний текст джерелаАнотація:
Thesis Ph. D.)(Chemical Engineering)--University of Pretoria, 2003.Title from opening screen (viewed Oct. 06, 2004). Summaries in English and Afrikaans. Includes bibliographical references (leaves 144-151).
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Maia, Mariana Cervaens Costa. "Hyperbaric oxygen therapy in sports medicine." Doctoral thesis, [s.n.], 2013. http://hdl.handle.net/10284/4224.
Повний текст джерелаАнотація:
Doutoramento em Biotecnologia e Saúde, especialidade em Epidemiologia e Saúde PúblicaAs lesões desportivas são um grande problema no que diz respeito à sua rápida reabilitação. Inúmeros estudos tentam encontrar a técnica mais rápida capaz de acelerar o processo da recuperação. A oxigenoterapia hiperbárica (OTH) é a aplicação de 100% de oxigénio numa câmara hiperbárica a pressões mais elevadas do que o nível do mar. A inalação de OTH comporta-se como um fármaco multifacetado dotado de efeitos anti-isquémicos, anti-hipóxicos, anti-edematosos, pós-lesão e anti-infecciosos. Portanto, o objetivo desta tese foi analisar a influência da OTH na recuperação de lesões desportivas, como contusão muscular e do ligamento cruzado anterior (LCA) pós ruptura. Em primeiro lugar, verificou-se se a aplicação de OTH melhorou as propriedades biomecânicas, tais como rigidez, alongamento máximo e peso máximo, dos gastrocnémios de ratos após induzir contusão muscular. Em segundo lugar, era de nosso interesse analisar, após de se ter induzido uma contusão muscular nos gastrocnémios dos ratos, a influência da OTH na bioenergética mitocondrial avaliada através do consumo de oxigénio e potencial transmembranar e susceptibilidade à indução do poro de transição de permeabilidade mitocondrial, em mitocôndrias isoladas. Finalmente, no último trabalho experimental, tentou-se verificar se a aplicação de OTH tem a capacidade de melhorar a neovascularização, por meio da análise do factor de crescimento do endotélio vascular (VEGF), bem como analisar a proliferação e a produção de proteína, em coelhos com ruptura do LCA. A OTH parece desempenhar um papel importante na recuperação de lesões musculares, mais especificamente, na contusão muscular em ratos, melhorando as propriedades biomecânicas musculares, tais como a rigidez e peso máximo e na bioenergética mitocondrial, onde o tempo até que o inchaço na mitocôndria iniciasse em grande escala foi menor no grupo submetido a OTH, assim como a amplitude de inchaço foi maior, o que atrasou a apoptose mitocondrial. Contudo, em relação à ruptura do LCA, a OTH promoveu a neovascularização, activando VEGF, mas no entanto, contribuindo para o aumento da espessura da cápsula. VII Palavras-chave: Oxigenoterapia hiperbárica, gastrocnémios, contusão muscular, propriedades biomecânicas, bioenergética mitocondrial, ligamento cruzado anterior, neovascularização, colagénio tipo I. Sports injuries is a major problem what concerns to its rapid rehabilitation. There is innumerous attempting to find the faster technique to apply to the injured ones to accelerate its recovery. Hyperbaric oxygen therapy (HBO) is the application of 100% oxygen in a hyperbaric chamber at pressures higher than sea level. The inhalation of HBO has already shown that behaves like a multifaceted drug endowed with anti-ischemic, anti-hypoxic, anti-edematous, pro-healing and anti-infective effects. Therefore, the objective of this thesis was to analyze the influence of HBO in the recovery from sports injuries such as muscle contusion and anterior cruciate ligament (ACL) rupture. Firstly, it was verified if HBO improved the biomechanical properties, such as hardness, maximum elongation and maximum weight, of rats’ gastrocnemius after inducing muscle contusion. Secondly, it was of our interest to analyze skeletal muscle mitochondrial energetic of rats’ gastrocnemius after induced muscle contusion, by determining end points related to oxygen consumption, transmembrane electric potential and permeability transition pore susceptibility in isolated mitochondria. At last, our last experimental work aimed to verify if HBO has the ability to improve neovascularization, through the analysis of vascular endothelial growth factor (VEGF) as well the proliferation and protein production, of rabbit ruptured ACL. HBO seems to play an important role in the recovery of muscle injuries, more specifically, muscle contusion in rats, by improving muscle biomechanical properties, such as hardness and maximum weight and in mitochondria energetic, where the time until large scale swelling initiates in mitochondria was lower in HBO and the swelling amplitude was higher, which delayed mitochondria apoptosis. However, concerning to ACL rupture, HBO increased neovascularization by activating VEGF, contributing for the increasing of capsule thickness. Les lésions sportives sont un grand problème en ce qui concerne la rapidité de sa réhabilitation. De nombreux études essayent de trouver la plus rapide et moins douloureuse technique capable d’accélérer le processus de récupération. L’oxygénothérapie hyperbare (OHB) consiste à l’inhalation de 100% d’oxygène dans un caisson étanche avec une pression plus élevée que celui de la mer. Il a été démontré que l’inhalation de l’OHB se comporte comme une drogue à multiple facette, qui permet d'agir sur l'ischémie tissulaire qu'elle qu'en soit la cause : vasculaire, traumatique, toxique, ou infectieuse. Pourtant, l’objectif de cette étude a été d’analyser l’influence de l’OHB dans la récupération des lésions sportifs, l’ecchymose du ligament croisé antérieur post rupture. Dans un premier temps, on a vérifié si l’utilisation de l’OHB améliore les propriétés biomécaniques, comme la rigidité, l’étirement maximum et le poids maximum, des Gastrocnémiens chez les rats après induire une ecchymose. Deuxièmement, cela été dans notre intérêts d’analyser, après induire une ecchymose des Gastrocnémiens chez les rats, l’influence du OBH dans la bioénergétique mitochondriale, évalué à travers la consommation d’oxygène, le potentiel transmembranaire et la susceptibilité d’induction du pore de transition de perméabilité mitochondrial, des mitochondries isolés. Pour finir, lors du dernier travail expérimental, nous avons essayé de vérifier si l’application de l’OHB a la capacité d’amélioré la néo vascularisation, en analysant le facteur de croissance de l’endothélium vasculaire (en anglais Vascular endothelial growth factor, VEGF), en analysant aussi la prolifération et la production de protéine, sur des lapins avec rupture du LCA. L’OHB semble avoir un rôle important dans la récupération des lésions musculaires, plus précisément sur l’ecchymose chez les rats, améliorant ainsi les propriétés biomécaniques musculaires, comme la rigidité, le poids maximum et la bioénergétique mitochondriale. Le temps pour que l’oedème dans la mitochondrie arrive à grande échelle a été plus faible dans le groupe soumis à l’OHB, comme l’amplitude de l’oedème fut plus grand, ce qui a retardé XI l’apoptose mitochondrial. Toutefois, en ce qui concerne la rupture du LCA, l’OHB a promu la néo vascularisation, activant le VEGF, contribuant à une capsule épaisse.
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Hodge, Rachel Elizabeth. "Coping During Hyperbaric Oxygen Therapy: Predictors and Intervention." Thesis, University of Canterbury. Psychology, 2008. http://hdl.handle.net/10092/2167.
Повний текст джерелаАнотація:
The present research sought to understand patient experiences during Hyperbaric Oxygen Therapy (HBOT) by using 24 HBOT patients (17 men, 7 women) to examine the relationship between individual variables and anxiety, and providing One Session Exposure Therapy (OSET; Öst, 1989) if necessary. Pre-HBOT participants completed the following measures: State-Trait Anxiety Inventory (STAI; Spielberger, 1983), Claustrophobia Questionnaire (CLQ; Radomsky, Rachman, Thordarson, McIsaac, & Teachman, 2001), Anxiety Sensitivity Index (ASI; Reiss, Peterson, Gursky, & McNally, 1986), and Treatment Credibility/Expectancy Questionnaire (CEQ; Devilly & Borkovec, 2000). State Anxiety was assessed pre-HBOT and at the tenth and last sessions. Findings suggest Dispositional Anxiety (STAI-Trait + ASI), Expectancy of symptom improvement (CEQ), and gender were significantly predictive of State Anxiety before and during HBOT. Limitations and directions for future research are discussed.
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Hodges, Alastair N. H. "Effect of hyperbaric oxygen on venous PO2, transcutaneous PO2, and VO2max in a normobaric environment." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=30175.
Повний текст джерелаАнотація:
Purpose. The purpose was to examine venous PO2, transcutaneous tissue PO2 (PtcO 2), and VO2max in a normobaric environment following a single HBO2 treatment. Methods. Ten moderately trained (VO2max = 57.6 mL·kg-1·min -1) males volunteered for the study. Baseline testing included measures of VO2max, PtcO2, and anthropometry. Subjects received two HBO2 treatments, which consisted of breathing 95% oxygen at 2.5 ATA for 90 min. Following the first HBO2 treatment (6.0 +/- 1.0 min), subjects performed a VO2max test. Following the second HBO2 treatment, leg and chest PtcO2 and venous PO2 were monitored for 60 min. Results . VO2max, running time, and peak La were not altered (p < 0.05) post-HBO2 treatment. Leg PtcO2 was lower (p < 0.05) and chest PtcO2 was unchanged following the HBO2 treatment compared to baseline values. Venous PO2 was lower in the first 3 min post-HBO2 treatment than subsequent values, but no other differences were found (p < 0.05). Conclusion. The results of this study show that a single HBO 2 treatment at 2.5 ATA for 90 min does not elevate venous PO2, PtcO2, or VO2max in a normobaric, normoxic environment.
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Philips, Alyssa. "EFFECTS OF HYPERBARIC OXYGEN ON STAPYLOCOCCUS AUREUS." OpenSIUC, 2018. https://opensiuc.lib.siu.edu/theses/2328.
Повний текст джерелаАнотація:
Hyperbaric Oxygen Therapy (HBOT) is an old technology which has acquired value in chronic wound care. HBOT is known to promote local and systemic healing effects by improving the oxygenation of the wound tissue. The increased tissue oxygenation hastens removal of the bacterial bioburden, which allows resolution of inflammation and facilitates matrix production, cell division, and ultimately wound closure. Staphylococcus aureus is the most frequently isolated organism from Diabetic Foot Infections (DFI). Therefore, our lab chose to use the treatment paradigm of HBOT to initially look at the single species level as to how HBOT affects S. aureus. DFI are primarily polymicrobial, so the responses of bacterial communities to this therapy were also considered. Previous research focused solely on host response to HBOT, but our pilot testing indicates that HBOT also exhibits a bacterial response. Initial testing with S. aureus indicated that HBOT can create growth defects in bacteria in vitro. In preliminary experiments, our lab discovered that bacterial culture on solid medium is greatly altered under the pressure of hyperbaric oxygen. Normal robust growth and pigmentation are seen in S. aureus cultured in ambient conditions. However, when the same strain is cultured under HBOT conditions, there is a marked decrease in pigmentation and colony size. When other species were exposed to HBOT conditions, growth on solid media was significantly diminished. Interestingly, K. pneumoniae is able to grow normally under HBOT conditions. Normal air mixtures at the increased pressure do not have any discernable effect on bacterial growth, and the limiting effects of oxygen are not seen unless used at the increased pressure. In a broth macrodilution MIC assay, various antibiotics show an increase in susceptibility after exposure to HBOT. Lastly, biofilm formation is altered under HBOT conditions, further supporting a bacterial adjustment to HBOT and an altered mode of growth. In order to better understand the effects of a high pressure high oxygen environment on the bacterial bioburden, this study investigates the effects of HBOT on bacterial species comprising a chronic wound. Primary data has suggested that HBOT increases susceptibility of antibiotics, and can alter bacterial transcription to hinder growth of many organisms. We hypothesize that Hyperbaric Oxygen Therapy affects diabetic foot infections by changing the healing process via transcriptional alteration of bacterial species in the wound. Furthermore, we hypothesize that HBOT alters the efficacy of some antibiotics as well as affecting the biofilm capacity of many bacterial species.
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Williamson, Raymond Allan. "An experimental study of the use of hyperbaric oxygen treatment to reduce the side effects of radiation treatment for malignant disease." University of Western Australia. School of Anatomy and Human Biology, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0063.
Повний текст джерелаАнотація:
[Truncated abstract] Therapeutic Radiation has been used for the treatment of cancer and other diseases for nearly a century. Over the past 20 years, Hyperbaric Oxygen Treatment (HBOT) has been used to assist wound healing in the prevention and treatment of the more severe complications associated with the side effects of Therapeutic Radiation Treatment (TRT). The use of HBOT is based on the premise that increased oxygen tissue tension aids wound healing by increasing the hypoxic gradient and stimulating angiogenesis and fibroblast differentiation. As it takes up to 6 months for a hypoxic state to develop in treated tissue, following radiation treatment, current recommendations for HBOT state that it is not effective until after this time. During this 6 month period, immediately following TRT, many specialized tissues in or adjacent to the field of irradiation, such as salivary glands and bone, are damaged due to a progressive thickening of arteries and fibrosis, and these tissues are never replaced. Currently, HBOT is used to treat the complications of TRT, but it would be far better if they could be prevented . . . In summary, this experimental model has fulfilled its prime objective of demonstrating that HBOT is effective in reducing the long-term side effects of therapeutic radiation treatment in normal tissue, when given one week after the completion of the radiation treatment and statistically disproves the Null Hypothesis that there is no difference in the incidence of postoperative complications or morbidity of TRT when 20 intermittent daily HBOT are started one week after completion of TRT. This project provides an extensive description of the histological process and also proposes a hypothesis for the molecular events that may be taking place.
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Al-Hadi, Hadil. "The effect of Hyperbaric Oxygen Therapy on osteoclast and osteoblast function." Thesis, University of Plymouth, 2013. http://hdl.handle.net/10026.1/1614.
Повний текст джерелаАнотація:
Bone remodelling, the process by which the skeleton adapts to environmental changes, is dependent on the actions of osteoclasts that resorb bone and osteoblasts which make new bone matrix. Aberrant remodelling underpins bone loss in several debilitating skeletal diseases such as osteoporosis, metastatic breast cancer and multiple myeloma. Changes in remodelling activity can also arise as a consequence of therapeutic intervention for instance intravenous bisphosphonate treatment is associated with osteochemonecrosis of the jaw and localised osteoradionecrosis is a common side effect of radiotherapy. Hyperbaric oxygen is often used as an adjunctive therapy in the treatment of these disorders. HBO involves the administration of 100% oxygen at atmospheric pressures greater than one in sealed chambers. The following studies aimed to evaluate the effect of HBO, hyperoxia, and pressure on RANKL-induced osteoclast differentiation and bone resorption from RAW264.7 and human peripheral blood mononuclear cells (PBMC), and osteoblast differentiation in vitro. The study also aimed to further examine the effect of HBO on ex vivo osteoclast formation from peripheral blood monocytes obtained from patients undergoing HBO. Daily exposure to HBO for ninety minutes significantly suppressed osteoclast differentiation and bone resorption in mouse and human monocytes in normoxic and hypoxic conditions in vitro. The suppressive action of HBO on osteoclast formation was associated with a significant reduction in HIF-1α and RANK mRNA expression and HBO also caused a significant reduction in NFATc1 and DC-STAMP expression. This study has for the first time shown that HBO is able to reduce the ability of precursors to form bone resorbing osteoclast. HBO also suppressed the ability of peripheral blood monocytes to develop into RANKL-induced resorptive osteoclasts. In an ex vivo culture system the suppressive effect of HBO was meditated by an action prior to activation of osteoclast differentiation by RANKL and must therefore be an inhibitory effect on the ability of precursors to differentiate along the osteoclastic lineage. HBO also accelerates the rate of osteoblast differentiation and augments early stages of mineralization and has a more pronounced effect than hyperoxia or pressure alone. HBO enhanced bone nodule formation and ALP activity in human osteoblasts. Furthermore HBO promoted the expression of type I collagen and Runx-2 in both normoxic and hypoxic conditions. HBO had a greater effect on these key markers of osteoblast differentiation than hyperoxia or pressure alone. This study suggests that HBO suppresses osteoclast activity and promotes osteoblastic bone formation, which may at least in part mediate its beneficial effects on necrotic bone. This provides evidence supporting the use of HBO as an adjunctive therapy to prevent osteoclast formation in a range of skeletal disorders associated with low oxygen partial pressure. The study also provides further support for the use of HBO in the treatment of skeletal disorders associated with excessive resorption such as osteomyelitis, and also provides a potential mechanism through which short term HBO may help fracture healing.
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Al-mzaiel, Anwar J. "Mechanisms by which hyperbaric oxygen therapy may resolve inflammation in chronic wounds." Thesis, University of Plymouth, 2013. http://hdl.handle.net/10026.1/1945.
Повний текст джерелаАнотація:
Hyperbaric oxygen (HBO) therapy is the intermittent inhalation of 100% oxygen at a pressure greater than one atmosphere absolute. It is an effective treatment for various inflammatory conditions, including chronic wounds which are characterized by an excessive influx of neutrophils and their prolonged persistence at the wound site. Neutrophil apoptosis and clearance have been shown to be required for resolution of inflammation. The mechanisms by which HBO aids wound healing are well documented, but its effects on cellular inflammatory response are not well understood particularly with respect to neutrophils. The hypothesis presented in this thesis is that increased oxygenation via HBO assists chronic wound healing by enhancing non-inflammatory neutrophil defences and cell death through apoptosis. An investigation was carried out into the effects of HBO on neutrophil antimicrobial function and apoptosis using differentiated HL-60 cells as an in vitro neutrophil model. The data clearly showed that a single HBO treatment for 90 min caused an increase in the oxidative burst activity of neutrophil-like cells as shown by increased NBT staining, superoxide (cytochrome c reduction) and H2O2 production (Kruskal-Wallis, P < 0.05), and phagocytosis of Staphylococcus aureus. HBO treatment displayed a pro-apoptotic effect, enhancing caspase 3/7 activity both in the presence and absence of a TNF-α stimulus (Kruskal-Wallis, P < 0.05) and causing morphological changes (observed using Giemsa and SYBR® Safe staining) associated with apoptosis. Although no consistent pattern was observed, both hyperoxia and pressure alone seemed to contribute to both the increase in antimicrobial activity and the increase in apoptosis induced by HBO in these neutrophil-like cells (Chapters 4 and 5). HBO-enhanced neutrophil clearance by macrophages was investigated using bovine neutrophils and monocyte-derived macrophages (MDMФ). A single 90 min HBO exposure significantly increased the clearance of fresh and 22 h-aged neutrophils by MDMФ (two-way ANOVA, P < 0.05), suggesting an increase in phosphatidylserine (PS) exposure in apoptotic neutrophils after HBO treatment (Chapter 6). Importantly, a long-term repetitive exposure to HBO in patients with chronic wounds caused a significant decrease in the antioxidant enzyme defence system (one-way repeated measures ANOVA, P < 0.05), plasma TNF-α and IL-1β after 30 HBO sessions, with down regulation of expression of the anti-apoptotic factors, NF-B and Bcl-2 (Chapter 7). These findings may go some way towards explaining the effectiveness of HBO treatment not only for chronic wounds but also for other inflammatory conditions that may be affected by this treatment.
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Muhonen, Arja. "Distraction osteogenesis of irradiated rabbit mandible with and without hyperbaric oxygen therapy." Turku : Turun Yliopisto, 2002. http://catalog.hathitrust.org/api/volumes/oclc/50131839.html.
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Collins, Michael J. "The Use of Hyperbaric Oxygenation Therapy to Change Cerebral Metabolism Rates in Patients with Chronic Brain Damage." NSUWorks, 2009. http://nsuworks.nova.edu/cps_stuetd/20.
Повний текст джерелаАнотація:
Hyperbaric Oxygenation Therapy (HBOT) has a successive history for treating very specific groups of physical conditions. Research by Neubauer and colleagues states that HBOT's ability to increase cerebral metabolism in the brain regenerates dormant neural tissue (Neubauer, Gottlieb, & Pevsner 1994). According to this research, the increase of cerebral metabolism levels restores mental capacity from the neurological insult. Despite promise, uncertainty exists as to whether this is a viable treatment option for people suffering from neural damage. The research results for this experiment will examine the effect of HBOT on cerebral metabolism levels in adults and pediatrics with chronic neurological problems. Fifty individuals diagnosed as having a neurological impairment whom met criteria for the study were analyzed from an archival data set. Criterion required chronic impairment, baseline SPECT, followed by HBOT exposures, and a post SPECT scan. Statistical analyses consisted of a Pearson correlation that examined pre-metabolism rates with total change, a Pearson correlation that examined total change and number of treatments, and a one way ANOVA analysis that examined cerebral metabolism change in patients under 18 and over 18. Results indicated change
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Abdulaal, A. A. M. (Adel). "A survey of the knowledge of the military and civilian medical practitioners in the Royal Medical Service in the Kingdom of Bahrain with regards to the clinical application of hyperbaric oxygen therapy." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20049.
Повний текст джерелаАнотація:
Thesis (MScMedSc)--Stellenbosch University, 2012.ENGLISH ABSTRACT: A survey was conducted between 3 August and 5 October 2011 to test and evaluate the knowledge and attitudes of the military and civilian medical practitioners at the royal medical Service in the kingdom of Bahrain with regards to the clinical application of hyperbaric oxygen therapy. The survey consisted of a questionnaire and a semi-structured interview in which a total of 93 (out of a possible 302) medical practitioners were included (13 participated in the interviews). Similar to findings of previous studies, the knowledge of medical practitioners in Bahrain regarding hyperbaric oxygen therapy was low. Several practitioners were able to mention at least one indication for the therapy. No single factor had a statistically significant association with knowledge or the lack thereof. A large proportion of the participants had a positive attitude towards the use of hyperbaric oxygen therapy, felt that it is a valid treatment modality and they would refer their patients for such treatment. They would like to receive more information on hyperbaric oxygen therapy. Educational interventions to address the knowledge gap would likely be effective, since most participants have a positive attitude towards the therapy and believe that it is cost-effective.
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Silva, Catarina Sousa da. "A oxigenoterapia hiperbárica nas lesões neuro-músculoesqueléticas: um estudo retrospetivo." Bachelor's thesis, [s.n.], 2018. http://hdl.handle.net/10284/7011.
Повний текст джерелаАнотація:
Projeto de Graduação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciada em FisioterapiaObjetivo: Efetuar um levantamento de dados, através de uma análise retrospetiva, sobre a eficácia da Oxigenoterapia Hiperbárica (OTH) na reabilitação de sequelas neuro-músculoesqueléticas provocadas pela Doença de Descompressão (DD) e verificar quantos e que casos precisaram da fisioterapia. Metodologia: A amostra foi constituída por 140 indivíduos, com uma média de idades de 35,31 ± 9,49 anos, que tenham recebido tratamento de OTH em Portugal continental, nomeadamente nos serviços de medicina hiperbárica do Hospital Pedro Hispano (Matosinhos) e no centro médico subaquático de hiperbárica do Hospital das Forças Armadas (Lisboa) com o diagnóstico de DD. Resultados: Desta amostra, 129 (92,1%) dos indivíduos eram do género masculino e apenas 11 (7,9%) do género feminino. Do total, 111 (79,3%) pertenciam ao Hospital das Forças Armadas e 29 (20,7%) ao Hospital Pedro Hispano. A DD tipo 1 teve como resultado 60 (42%) de prevalência e o tipo 2 de 74 (52,9%) em 134 indivíduos, havendo 6 (4,3%) omissos. Apenas os diagnosticados com DD tipo 2, com comprometimento medular, 6 (8,1%) indivíduos realizaram fisioterapia. Conclusão: A OTH é o tratamento gold-standard para a DD e que a necessidade da fisioterapia, como tratamento complementar, revelou-se importante na DD tipo 2 com comprometimento medular.
Objective: To conduct a data collection, through a retrospective analysis, on the efficacy of Hyperbaric Oxygen Therapy (HBO) in the rehabilitation of neuro-musculoskeletal sequelae caused by Decompression Disease (DD) and to verify how many and which cases required physiotherapy. Methodology: The sample consisted of 140 individuals, with a mean age of 35.31 ± 9.49 years, who had received HBO treatment in mainland Portugal, namely in the hyperbaric medicine services of Pedro Hispano Hospital (Matosinhos) and in the underwater hyperbaric medical center of the Armed Forces Hospital (Lisbon) with the diagnosis of DD. Results: Of this sample, 129 (92.1%) of the individuals were male and only 11 (7.9%) were female. Of the total, 111 (79.3%) belonged to the Armed Forces Hospital and 29 (20.7%) to the Pedro Hispano Hospital. Type 1 DD was prevalent in 60 (42%) and type 2 in 74 (52.9%) of 134 individuals, with 6 (4.3%) without information. Only 6 (8.1%) individuals underwent physiotherapy diagnosed with type 2 DD, all with spinal cord involvement. Conclusion: HBO is the gold standard treatment for DD and the need for physiotherapy, as a complementary treatment, has been shown to be important in type 2 DD with spinal cord involvement.
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Leite, Magno Santos. "Alterações estruturais de corpos carotídeos de ratos expostos à hiperoxigenação hiperbárica." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-13022008-100815/.
Повний текст джерелаАнотація:
Procurou-se confirmar a existência de alterações estruturais em corpos carotídeos de ratos expostos à hiperóxia que pudessem explicar a atenuação da resposta fisiológica à hipóxia nessas condições descrita na literatura. Também testamos a hipótese de haver um desvio de fluxo sanguíneo para os capilares intraglômicos em situações de hiperoxigenação hiperbárica.15 ratos machos Wistar adultos foram divididos em 3 grupos e expostos a 2,4 ATA por 6 horas, a 3,0 ATA por 6 horas e a ar ambiente (grupo controle). Os resultados obtidos através de análise histológica e morfométrica mostraram: a) nenhuma alteração da arquitetura dos corpos carotídeos, mas as células expostas à dose mais elevada apresentaram-se com citoplasma desarranjado, confirmado pela microscopia eletrônica; b) um aumento significativo da densidade volumétrica de capilares preenchidos por hemácias, mas não do estroma intersticial, no grupo exposto à dose mais elevada de O2 c) uma vasoconstricção significativa das arteríolas maiores em todas as doses de oxigênio empregadas no estudo e das arteríolas menores na dose mais elevada de O2; d) variações significativas na proporção das variantes de células glômicas no grupo exposto a menor dose de O2; e) mitocôndrias com poucas cristas, tanto nas células glômicas quanto nas terminações nervosas, embora nas primeiras apresentem-se bem deformadas; f) proliferação membranosa citoplasmática com aumento de REG e Golgi nas células glômicas e sustentaculares. Esses resultados sugerem um desvio do fluxo dos vasos mais calibrosos em direção aos capilares intraglômicos, confirmando nossa hipótese inicial e indicam que o oxigênio, dependendo da dose utilizada, exerce um efeito tóxico importante sobre os corpos carotídeos, com alterações significativas da ultraestrutura das células glômicas e terminações nervosas.We sough to confirm the existence of structural alterations in rat carotid bodies exposed to hyperoxia that could explain the attenuation of the ventilatory hypoxic drive (HD) by hyperoxic conditions described in the literature. We also tested the hypothesis of there being a deviation of blood flow toward intraglomic capillaries in situations of hyperbaric oxygenation (HBO).15 adult male Wistar rats were divided in 3 groups and exposed to O2 at 2.4 ATA for 6 hours, at 3.0 ATA for 6 hours and to air at 1.0 ATA (control group). The results obtained through histological and morphometric analysis showed: a) no alteration in the architecture of the carotid bodies, but the cytoplasm of the cells exposed to the highest dose were disarranged, a feature confirmed by electron microscopy; b) a significant increase in volume density of capillaries filled out by red blood cells but not of interstitial stroma in the group exposed to O2 at the highest dose; c) a significant vasoconstriction of larger arterioles in all doses of oxygen employed in the study and of smaller arterioles at the highest dose of O2; d) significant variations in the proportion of glomic cell variants in the group exposed to the lowest dose of O2; e) mitochondria with few cristae, so in glomic cells as in nerve-endings, although in the former they were very deformed; f) cytoplasmic membranous proliferation with an increase of endoplasmic reticulum and Golgi apparatus in glomic and sustentacular cells. These results suggest a deviation of blood flow from more calibrated vessel toward intraglomic capillaries, confirming our initial hypothesis and indicate that oxygen, depending on the dose used, exerts an important toxic effect on rat carotid body with significant alterations of glomic cell and nerve-endings ultrastructure.
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Colombari, Gleice Cristina. "Otoproteção à lesão pelo ruído: efeitos da Oxigenoterapia Hiperbárica e Corticoide." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/17/17150/tde-12012017-145722/.
Повний текст джерелаАнотація:
As investigações sobre os efeitos da oxigenoterapia hiperbárica (OHB) em lesão por ruído são escassas e apontam para diferentes efeitos em função do momento de intervenção. Dentre os trabalhos já descritos foi observado efeito lesivo da OHB quando aplicada imediatamente ao trauma acústico, contudo, efeito positivo foi observado quando aplicada após 2 e 6 horas. Com relação aos tratamentos usados para trauma acústico, alguns estudos descrevem o uso de corticoides como melhor alternativa, mas recentemente estudos apontam para a sua combinação com OHB como a terapêutica com maior beneficio nas lesões por ruído. O presente estudo teve como objetivos avaliar o momento da intervenção pela OHB após 2, 4 e 6 horas de repouso auditivo após exposição ao ruído e avaliar a associação terapêutica entre a OHB e corticoterapia (CT). Cobaias albinas foram expostas a um ruído branco na faixa de 4 kHz com intensidade igual a 110dB NPS por 72h e divididas em cinco grupos terapêuticos: OHB com início após 2, 4 e 6h de repouso auditivo após exposição ao ruído, CT isolada e OHB após 6 horas de repouso associada a CT. O tratamento durou 5 dias, sendo uma sessão terapêutica por dia. Todos os animais tiveram a função auditiva avaliada pelo Potencial Evocado Auditivo de Tronco Encefálico (PEATE) e pelas Emissões Otoacústicas Produtos de Distorção (EOAPD) em três momentos: pré-ruído, pós-ruído e pós-tratamento. Após a eutanásia dos animais e preparação dos espécimes cocleares, todas as cócleas foram analisadas através de Microscopia Eletrônica de Varredura (MEV). Não houve diferença estatística significativa entre os momentos de intervenção pela OHB após 2, 4 e 6 horas, contudo, os dados de MEV demonstraram que uma maior otoproteção ocorreu quando a intervenção foi realizada após um maior repouso auditivo. Apesar da não diferença estatística significativa, os achados anatômicos e funcionais permitiram concluir que a associação terapêutica entre a OHB e a corticoterapia desempenhou um melhor efeito otoprotetor e terapêutico se comparada a essas mesmas terapias isoladas.Investigations on the effects of hyperbaric oxygen therapy (HBOT) in noise injury are scarce and point to different effects depending on the time of intervention. Among the work already described has been observed damaging effect of HBOT when applied immediately after the acoustic trauma, however, positive effect was observed when applied after 2 and 6 hours of rest after the trauma. Studies describe the use of corticosteroids as the best alternative to treat acoustic trauma, but recent studies point to their combination with HBOT as the major benefit in lesions by noise. This study aimed to evaluate the time of intervention by HBOT after 2, 4 and 6 hours of rest after hearing noise exposure and to evaluate the association between HBOT and corticoid. Female guinea pigs were exposed to a white noise on 4kHz at 110dB SPL during 72 hours and divided into five treatment groups: HBOT after 2, 4 and 6 hours of rest after the noise exposure, corticosteroid therapy and HBOT combined with corticoid. The treatment lasted five days, being a therapy session per day. All animals were exposed to Distortion Product Otoacoustic Emissions (DPOAE) and Auditory Brainstem evoked Response (ABR) in three moments: before and after exposure to the noise and after the treatment. All cochleae were examined by scanning electron microscopy (SEM). There was no statistically significant difference between the moments of intervention by HBOT after 2, 4 and 6 hours, however, the SEM data showed that a greater otoprotection occurred when the intervention was performed after a higher auditory rest. Although not statistically significant, the anatomical and functional findings concluded that the association between HBOT and corticosteroid therapy played a better otoprotective and therapeutic effect compared to those same therapies alone.
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Silva, Kauan Ribeiro da. "Princípios da terapia hiperbárica em animais de companhia." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2019. http://hdl.handle.net/10400.5/18560.
Повний текст джерелаАнотація:
Dissertação de Mestrado Integrado em Medicina VeterináriaA terapia hiperbárica é uma modalidade terapêutica onde o doente beneficia do aumento da pressão atmosférica para melhorar a distribuição e o aproveitamento do oxigénio (O2) pelos tecidos corporais. Para tal, é necessário recorrer-se a câmaras capazes de elevar a pressão atmosférica no seu interior, aumentando opcionalmente a concentração de O2 inalada pelo doente. Se a concentração inalada de O2 for aumentada através do fornecimento de O2 a 100%, denomina-se de Oxigenoterapia Hiperbárica; mas se a concentração inalada de O2 for igual à pressão atmosférica, denomina-se de Terapia com Ar Hiperbárico. A terapêutica hiperbárica é ainda incipiente na Medicina Veterinária, apesar das suas conhecidas vantagens na Medicina Humana. O presente trabalho procura explicar um pouco sobre como funciona a Terapia Hiperbárica em pequenos animais, considerando os seus princípios físicos funcionais, indicações e contraindicações, ilustrando no final com o relato de um caso clínico de um canídeo, fêmea, 9 anos de idade, com diagnóstico diferencial primário de isquémica cerebral difusa, sujeita a terapêutica médica e hiperbárica. A medicina hiperbárica é uma modalidade terapêutica promissora com indicação para uma grande variedade de doenças mas ainda carece de mais estudos para que possa ser melhor entendida.
ABSTRACT - The hyperbaric medicine is a therapy modality where the patient benefits from the increase of the atmospheric pressure to improve the distribution and utilization of the oxygen (O2) by the body tissues. For this, it is necessary to resort to special chambers, capable of raising the atmospheric pressure inside itself, optionally increasing the O2 concentration inhaled by the patient. If the concentration of inhaled oxygen increases by the supply of O2 on 100%, it is called Hyperbaric Oxygen Therapy, if the concentration of O2 inhaled is equal to the atmosphere, it is called Hyperbaric Air Therapy. The hyperbaric medicine is still insipient in Veterinary Medicine, despite its known advantages in Human Medicine. This work seeks to explain a little how the Hyperbaric Therapy works in small animals, considering its functional physical principles, indications and contraindications. For this, it illustrates the story of a clinical case, a 9-year-old female canine with primary differential diagnosis of defuse cerebral ischemic, subject to medical and hyperbaric therapy. Hyperbaric medicine is a promising therapeutic modality, applicable in the veterinary clinical routine, with an indication for a wide variety of diseases, but which still requires further studies in the veterinary medicine.
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Faria, Rubens Alexandre de. "Estudo e desenvolvimento de instrumentação para monitoração de parâmetros fisiológicos em pacientes submetidos a oxigenoterapia hiperbárica (HBO)." Universidade Tecnológica Federal do Paraná, 2011. http://repositorio.utfpr.edu.br/jspui/handle/1/339.
Повний текст джерелаАнотація:
A câmara hiperbárica, equipamento pelo tratamento de diversos tipos de doenças ou síndromes, possui uma restrição muito grande quanto à instrumentação biomédica utilizada para monitoramento dos pacientes, devido ao alto risco de fogo ou explosão, por trabalhar com oxigênio (O2)sob pressão. No presente trabalho é descrito o desenvolvimento de um dispositivo biotelemétrico ativo, porém de baixo consumo e menor possível envolvida, capaz de monitorar, em tempo real, o sinal de ECG de um paciente sob tratamento hiperbárico. Para minimizar a possibilidade de se gravar níveis de calor suficientes para iniciar uma explosão,optou-se pelo uso de circuitos eletrônicos que, comparativamente, pudessem operar com os menores níveis de energia. Além disso, procurou-se evitar o uso de materiais que em contato com o O2 puro pudessem causar reações químicas que levassem a uma explosão. Neste sentido, optou-se por alimentar o dispositivo usando-se células fotovoltaícas, evitando assim o uso de baterias. Para se chegar a este desenvolvimento, estudaram-se os níveis de campo elétrico necessários para a deflagração de faíscas elétricas (Curvas de Paschen) dentro de uma câmara hiperbárica protótipo contendo O2 sob pressão. Os resultados definem uma relação segura entre a tensão aplicada e a distância entre as partes condutoras de um circuito eletrônico dentro da câmara (trilhas da placa de circuito impresso ou terminais de componentes).Hyperbaric chambers are a kind of equipament used to treat several illness or syndromes. However, it is very dangerous whenever electronic instruments are used inside it, because the chamber has oxygen (O2) under pressure and the equipment can originate fires, specially due to the generation of sparks. In the present work, it is described the development of an active biotelemetric device. The circuit is capable to monitor, in real time, the ECG signal of a patient during hyperbaric treatment. To minimize the possibility of generating temperature values high enough to initiate an explosion, it was chosen to use electronic circuits that, comparative, could operate with low levels of energy. Moreover, materials that when in contact with pure O2 could cause chemical reactions that would lead to an explosion, have been avoided. In this direction, it was chosen to feed the device using photovoltaic cells, thus avoiding the use of batteries. To reach this development, the necessary levels of electric field for the deflagration of electric sparks have been studied (by Paschen’s Curves) and tests inside a prototype hyperbaric chamber, using O2 under pressure, have been carried out. The final results define a safe relation between applied voltage and the conductive electronic circuit parts inside the chamber (copper trace and pads of the printed circuit board).
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Pirone, Christy Joan. "The hyperbaric incident monitoring study (HIMS) : an international study of incidents occuring in hyperbaric medicine units." Thesis, 2000. http://hdl.handle.net/2440/110129.
Повний текст джерелаАнотація:
Analyses incidents which occured in hyperbaric medicine units, or as a consequence of hyperbaric oxygen exposure, with the aim of developing recommendations for safety improvement in hyperbaric medical practice. A review of the hyperbaric literature showed that ear barotrauma is the most frequently reported patient complication of hyperbaric treatment, with the second most frequently reported complication being oxygen toxicity. From the data, the study presents recommendations for quality improvement, research, policy and procedure development, education and equipment design modification.Thesis (M.Clin.Sc.) -- University of Adelaide, Dept. of Clinical Nursing, 2001.
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Hodge, Rachel E. "Coping during hyperbaric oxygen therapy : predictors and intervention : a thesis submitted in partial fulfilment of the requirements for the degree of Master of Science in Psychology at the University of Canterbury /." 2008. http://hdl.handle.net/10092/2167.
Повний текст джерелаАнотація:
Thesis (M. Sc.)--University of Canterbury, 2008.Typescript (photocopy). "Supervised by Associate Professor Neville Blampied, Dr Lois Surgenor, and Dr Mike Davis." Includes bibliographical references (leaves 125-138). Also available via the World Wide Web.
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Wilkinson, David Cameron. "Hyperbaric oxygen and insulin sensitivity." Thesis, 2020. http://hdl.handle.net/2440/129616.
Повний текст джерелаАнотація:
Introduction: Obesity is associated with a chronic low grade inflammatory state and the development of insulin resistance and diabetes, while hyperbaric oxygen therapy (HBOT) has demonstrated anti-inflammatory properties. But it was the observation that people with diabetes were susceptible to a fall in blood glucose levels during HBOT that led to an investigation of insulin sensitivity. Methods: Five human studies were reported in four publications. Four studies used the hyperinsulinaemic euglycaemic glucose clamp and one used a frequently sampled intravenous glucose tolerance test (FSIGT) to investigate insulin sensitivity during HBOT. Studies recruited men who were overweight or obese, with and without diabetes. Blood samples for inflammatory cytokines and adipose tissue biopsies for gene expression were taken to investigate possible mechanisms of action. Results: A total of sixty-two men were investigated by glucose clamp and nine by FSIGT. All four glucose clamp studies showed significant within-group increases in insulin sensitivity following exposure to HBOT. First, in a group of patients with (n=5) and without diabetes (n=5) referred for clinical HBOT, there was a 37% increase during the third HBOT and 41% increase during the thirtieth HBOT. Next, in a group of men who were overweight or obese, we found a 29% increase in men without diabetes (n=11) and 57% increase in those with diabetes (n=8) during the third HBOT. Further, the effect was still measurable in the first 30 minutes after exit from the hyperbaric chamber. Pre and post-HBOT testing found reductions in serum TNF-α and MCP-1 while IL-6 increased. Next, in a group of men who were overweight or obese but without diabetes (n=9), we found a significant 23% increase during the first HBOT intervention. There was a significant increase in serum IL-6 after HBOT but no change in TNF-α or MCP-1. The final glucose clamp study randomised men to either HBOT (n=13) or hyperbaric air (n=11) and found a significant between group difference with a 26% increase in insulin sensitivity during HBOT but no significant change in hyperbaric air. The FSIGT study performed the insulin sensitivity test on men who were overweight or obese and without diabetes (n=9) during the third HBOT and 24-hours later but found no changes from baseline. Conclusions: The glucose clamp technique identified an acute increase in insulin sensitivity during HBOT. The effect could be seen in those without diabetes which suggests it is a physiological response to HBOT. Further research is encouraged into this insulin-sensitising effect of HBOT as it could open new therapeutic pathways for glucose regulation. No change to insulin sensitivity was seen in hyperbaric air; although it was a very modest exposure this may be relevant to people in other hyperbaric environments such as diving. The response of serum inflammatory cytokines to HBOT was inconsistent however two studies that showed increased insulin sensitivity during HBOT together with increased serum IL-6 suggest the origin and role of IL-6 requires further investigation.Thesis (Ph.D.) -- University of Adelaide, Adelaide Medical School, 2020
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Wu, Chih-Lung, and 吳志隆. "Hyperbaric Oxygen Therapy for Diabetic Foot." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/20788131464359498054.
Повний текст джерелаАнотація:
碩士中山醫學大學
醫學研究所
90
Abstract The prevalence of diabetes mellitus has increased in Taiwan recently. Foot infection and gangrene are frequent complication of DM patients. In many reports, hyperbaric oxygen therapy(HBOT) has been approved as an adjunctive therapy in the management of diabetic foot. But few publications show how to improve the success rate of HBOT in diabetic foot. The purpose of this study is an attempt to evaluate the failure factors of HBOT. From July 1999 to Dec. 2001, we retrospectively collected data on 49 patients with diabetic foot treated by HBOT. There were 19 females and 30 males, with an average age of 66.7 years. We defined successful treatment as wound healing or a low level amputation. Independent sample t-test and Fisher’s exact test were used to compare the successful cases with the failed cases according to age, blood sugar, peripheral vessel disease, leukocyte count, bacterial numbers and uremia. Using a Statistic Correlation to find the significant factors between success group and failure group related with the result of treatment. Logistic regression was used to identify the prognostic factors associated with the outcome of treatment. Of the 49 patients, 31 patients(success rate:63.3%) succeeded and 18 patients(failure rate:36.7%) failed in treating their diabetic foot by HBOT. We analyzed the data statistically and found the most important prognostic factor of treatment was peripheral vessel disease in hyperbaric oxygen therapy. Although many reports claimed that adjunctive hyperbaric oxygen therapy is a useful tool in treatment of diabetic foot, currently it is not recognized as a routine adjunctive method. The reason is that we can’t clearly predict HBO treatment result and it is costly in Taiwan. According to this study, we understand that peripheral circulation is the most important prognostic factor. Therefore, careful evaluation and preparation of patients is necessary before using HBOT. A treatment protocol for HBOT is proposed in Fig 1. Key words: Diabetic foot, Hyperbaric oxygen therapy, low level amputation, peripheral vessel disease, and leukocyte count
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江庭維. "Effects of Hyperbaric Oxygen Therapy for Scaphoid Fracture." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/7p4a34.
Повний текст джерелаАнотація:
碩士國立彰化師範大學
運動健康研究所
106
Scaphoid fracture is a common fracture of the wrist, with the highest incidence rate of about 70%. It is second to the distal tibial fracture in the upper extremity fracture. The victim/patient can suffered from pain, swelling, deformity and joint stiffness. In the past, the treatment of the scaphoid fracture was divided into two major categories; mainly surgical treatment and conservative treatment. Because the unique feature of scaphoid structure, anatomically there is only one specific blood vessel supplies to it. Ischemic osteonecrosis can occurs when the fracture destructs the only blood supply available When this happens, the regional hypoxia state will produce catastrophic and irreversible complications which will have a great impact on the athletes and cannot be ignored. In recent years, there have been many reports on the use of hyperbaric oxygen therapy in the treatment of fractures with excellent results. But so far there has been no research been reported on whether the treatment of scaphoid fractures is beneficial. It is because of limited number of technicians involved in hyperbaric oxygen therapy in Taiwan due to the rule and regulations, The purpose of this the study wes to investigate the efficacy of hyperbaric oxygen therapy in treating of newly diagnosed scaphoid fracture caused by trauma injury via retrospective review and data analysis. According to the age, treatment time, pain scale, X-ray review and analysis data, there was no significant difference in age and treatment time between these two groups, but however the pain scale after receiving HBO treatment showed significant difference (control group). 7.2 ± 1.1; experimental group 1 ± 1; p <0.01). Clinically, severe pain is an important prognostic indicator for scaphoid fractures and bone healing. Although this study is a small sample size, but it can be seen that there is an obvious benefit to the improvement of pain. In the future, it will be directed to the health authorities by applying a large-scale human clinical trial to demonstrate the prognosis of this treatment for scaphoid fractures. Furthermore, it is expected that hyperbaric oxygen therapy can be a routinely use of medical treatment for all patients who had scaphoid fracture.
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Al, Boloushi Zaid. "Hyperbaric Oxygen therapy in relation to production of free radicals." Master's thesis, 2009. http://www.nusl.cz/ntk/nusl-274944.
Повний текст джерелаАнотація:
Objectives. The purpose of this Thesis is to Create a Critical Review that describes the methods, results, and conclusions of a literature review of the benefits and harms of hyperbaric oxygen therapy (HBOT) and the relation to the free radical production "Oxidative Stress", the usage of the (HBOT) for brain injury, cerebral stroke, and some neurological disorders. Selection Criteria. We independently assessed each title and abstract using Predetermined inclusion criteria based on intervention, population, outcome measures, and study design criteria. Full papers, reports, and meeting abstracts that met inclusion criteria were retrieved and reviewed independently. Main Results. Determine whether the benefits of HBOT outweigh the potential harms. For other types of brain injury, no good- or fair-quality studies were found. No controlled trial of HBOT was designed to measure mortality in stroke patients, and the best studies found some what improvement in neurological outcomes. Evidence about the type, frequency, and severity of adverse events in actual practice is inadequate. Reporting of adverse effects was limited, and no study was designed specifically to assess adverse effects. Evidence from well-conducted clinical studies is limited. The balance of benefits and harms of HBOT for brain injury,...
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葉致廷. "Hyperbaric Oxygen Therapy Improve Heat Tolerance in Heat Stressed Mice." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/fg96hg.
Повний текст джерелаАнотація:
碩士南臺科技大學
生物科技系
107
Pregnant women are vulnerable population to be the most at risk of heat stroke reactions caused by high environmental temperatures. Here, we provide the first description of the mechanism underlying the decreased heat tolerance in pregnant mice under heat stress.ICR mice with or without pregnancy were exposed to whole body heating （WBH: 41.2℃, relative humidity 55 ± 10% for 1 h） in an environmental temperature-controlled chamber. Then, heated mice were treated with or without hyperbaric oxygen therapy （HBO2T） for 4 h immediately after the end of WBH. Mice that survived to hour 4 of WBH were considered survivors, and the data were used for analysis of the results. Four hours post-WBH, all of the animals were killed, and their blood and organs were removed for biochemical and/or histological evaluation. A statistically significant decrease in the fractional survival was observed in pregnant WBH mice compared with non-pregnant WBH mice （4/10 vs. 10/10）. Furthermore, pregnant WBH mice without HBO2T, but not non-pregnant controls, displayed hypothalamo-pituitary-adrenal （HPA） axis impairments evidenced by temperature dysregulation, hypothalamic neuronal degeneration and apoptosis, decreased plasma levels of adrenocorticotrophic hormone （ACTH） and corticosterone, hypothalamic inflammation and oxidative stress, and multiple organ injury. The heat intolerance caused by pregnancy was significantly attenuated by HBO2T. Decreased heat tolerance in pregnant mice under heat stress is related to HPA axis impairment. HBO2T may attenuate pregnancy-induced heat intolerance by normalizing the HPA axis activity.
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Chang, Tai-Hsiang, and 張台香. "The effect of hyperbaric oxygen therapy to tummor cell in vivo." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/23412215184927795316.
Повний текст джерелаАнотація:
碩士國防醫學院
海底醫學研究所
94
Hyperbaric Oxygen Therapy (HBOT) is the administration of 100% oxygen at atmospheric pressures greater than that at sea level. Hyperbaric oxygen therapy is commonly utilized to treat clinical diseases, such as carbon monoxide poisoning, decompression disease, arterial gas embolism, osteomyelitis, sever anemia, wound healing, and so on. However, malignant disease has been recognized as a contraindication to HBO2 since it might promote residual tumor growth. On the other hand, many studies have described the rapidly growing progression of tumor incurring hypoxia that would be close to the necrotic areas in tumors. Under certain hypoxic condition, tumor cell could become unstable and make gene mutation. Most genes induced by hypoxia are regulated by the hypoxia-induced factor -1 (HIF-1), a protein playing a very important role in tumor development. Vascular endothelial growth factor (VEGF) is also regulated by HIF-1 under transcription lever. Meanwhile, hypoxia activates transcription of the met protooncogene, resulting to higher levels of Met. The overexpression of HIF, VEGF and Met may be able to keep tumor cells proliferation and even metastasis. The purpose of this study was to establish tumor-hypoxia animal model, and to examine the effect of HBO2 therapy on tumor hypoxia, tumor growth and metastasis. First, we tested hypoxia and monitored the tumor growth separately on the 30th and 45th days after A549 tumor cell were implanted into SCID mice. Next, the tumor implanted mice were treated with NBO and HBO treatment 5 times a week at 2.5 atm absolute for 90 minutes (n=6), then sacrificed on 0, 14, 28 days . Immunohistochemical analysis was used to assist the examination on tumor hypoxia, vasculature expression of VEGF and Met. In the experiment, we have showed the significant differences (p<0.05) in the tumor volume, hypoxia and vasculature between the two growth (Control and HBO2). We concluded that hyperbaric oxygen treatment could decrease tumor hypoxic condition, change the density of tumor blood vessels and limit the growth of tumor. However, the detailed mechanism is still unclear further investigation.
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Chen, Wei-Yi, and 陳薇伊. "Analysis the effect on Hyperbaric oxygen therapy for Traumatic Brain Injury." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/93802239903182655629.
Повний текст джерелаАнотація:
碩士臺北醫學大學
傷害防治學研究所
95
In all injuries, traumatic brain injury (TBI) has the highest rate of mortality and disability. Therefore, it is an important issue to decrease the mortality and disability of TBI patients. Hyperbaric oxygen therapy (HBOT) in TBI patients is controversial in the past several decades. In this study, we evaluated the HBOT prognosis of TBI patients with the data of their Glasgow Outcome Scale (GOS), Extended Glasgow Outcome Scale (GOSE), and Disability Rating Scale (DRS), Glasgow coma scale (GCS), the score of the injury severity, and the times of their receiving HBOT. Ten patients received HBOT in a pressurized chamber. The treatment used with two absolute atmospheric pressure for 110 minutes. We collected two groups of TBI patients: 22 of them received HBOT and 22 did not received HBOT. The results of two groups of patients showed significant number of male patients. The average age in HBOT group was 34.8 years old while that in the control group was 40.1 years old. The improvement of the GCS in HBOT group was 8 to 13.63 points and that in the control group was 7.9 to 8.04.The differences of improvement scores of the two groups were significant (p<0.05). Moreover, both groups showed the GOSE improvement of 0.5 points from 3 to 1 month after the injury. The results of the study showed that the correlation scores existed between the days elapsed from the injury happened to the day that the patients’ HBOT and that the delay of HBOT was 0.05917 points lower (p<0.05) in GOS between the treated or the controlled group. Also significant difference was showed in their injury severity of the two groups for every one day of delayed therapy by 0.03088 points (p < 0.05). In conclusion, the data of this study showed that group HBOT had better recovery rate than control group in GCS and the injury severity.
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Alghamdi, Mohammed Y. M. "The Effects of Hyperbaric Oxygen Therapy on Bone Distant from Site of Surgery." Thesis, 2011. http://hdl.handle.net/1807/30161.
Повний текст джерелаАнотація:
Background: Hyperbaric Oxygen Therapy (HBOT) is used to promote soft and hard tissue repair at sites of injury or disease. It is not known whether it has any effect on uninjured tissues. Objective: To evaluate the effect of HBO on vertebral bones distant from a calvarial surgical site. Materials and Methods: 22 male New Zealand white rabbits were divided into two groups (n=11). All animals underwent surgery to produce bilateral calvarial critical sized defects. Group 1 received HBOT while Group 2 served as controls breathing room air (NBO). The Marx HBO protocol was used (90min, 100% oxygen at 2.4 ATA, 5 days a week for 4 weeks). Subjects were sacrificed at 6 weeks. The vertebrae were analyzed by micro-CT (μCT) and histology. Results: There were no statistical significant differences between the two groups. Conclusion: we concluded that there were no harmful effects of HBOT on non-injured vertebrae at 6 weeks.
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Tsai, Tsui Ting, and 蔡翠婷. "Knowledge, attitude and psycho-physiological response of patients towards hyperbaric oxygen therapy." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/r4gfuh.
Повний текст джерела
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HSIEH, I.-CHEN, and 謝宜蓁. "To Explore the Possible Mechanism of Hyperbaric Oxygen Therapy in Tumor Regression." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/4dehx9.
Повний текст джерелаАнотація:
碩士國防醫學院
微生物及免疫學研究所
104
Hyperbaric Oxygen Therapy (HBOT) is the administration of 100% oxygen at atmospheric pressure greater than normal situation. HBOT has been shown to have many benefits, including improvement of tissue hypoxia, promoting wound healing, and increasing the ability of white blood cells to kill bacteria. HBOT is utilized to treat clinical diseases, such as carbon monoxide poisoning, decompression disease, wound healing, and so on. Moreover, HBOT has been used to assist in the clinical treatment of cancer, promoting the tissue recovery after radiation therapy and chemotherapy. However, malignant disease has been recognized as a contraindications of HBOT because it might promote tumor growth. The current study describe the growing progression of tumor incurring hypoxia close to the necrotic area in tumor. In the hypoxia situation, tumor cell will become gene unstable and mutation. The high-pressure environment leads to increase the concentration of reactive oxygen within the tumor cells, break cell membrane, block the synthesis of DNA and protein and therefore suppress tumor cells growth and induce cell apoptosis. Recent studies indicate that autophagy can control energy requirement and the metabolism of the cell, and help forward cell survival in the harmful condition, especially in cancer pathogenesis. Autophagy can suppress oncogene expression and regulate anti-tumor immune response of T cell. In the previous study, we implanted A549 cells into mice to form tumors and then treated with hyperbaric oxygen therapy. Unexpectedly, we found the sizes of tumors were reduced and the mechanism was unknown. So we investigated the correlation between tumor regression and autophagy after HBOT used A549 cells treated HBOT as a model to explore the possible mechanism in vitro. We treated A549 cell with 2.5 atm or 3.5 atm absolute for 3 hours to 6 hours. Moreover, we recultured cell after HBOT. Western blotting was used to observe the autophagy-related protein expression. Furthermore, we also examined whether the DNA would be leaked from nucleus and induce chromatophagy after treated with HBOT. From the preliminary results indicated that cell growth after HBOT treated was suppressed and DNA leakage from nucleus was noted. We highly suspend HBOT treatment inducing chromatophagy and limiting tumor growth. The possible mechanism of this effect is taking measures.
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吳佳衡. "The Effect of Recovery from Fatigue After Exhaustive Exercise With Hyperbaric Oxygen Therapy." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/40723440550759546544.
Повний текст джерелаАнотація:
碩士國立新竹教育大學
體育學系碩士班
97
Introduction: The purpose of this study was to investigate the effect of recovery from fatigue after exhaustive exercise with Hyperbaric Oxygen Therapy (HBO). Method: Twelve subjects (age=17.1±0.9 yrs, height=175.3±3.5 cm, weight=65.1±6.5 kg) were recruited. This study adopted a repeated sample testing, all subjects were part of the four different groups at various stages of the investigation, which consisted of: (a) control group, (b) no HBO after exhaustive exercise, (c) HBO after exhaustive exercise, and (d) HBO without exhaustive exercise. HBO was applied on a periodical basis, inhaling 100% oxygen for 45 minutes in a 2ATA environment. The whole process took 90 minutes. To induce exercise fatigue, subjects had to run on a treadmill to enhance tiredness until they were exhausted. This study employed an analysis of covariance to test the effect of HBO on the recovery of creatine kinase, glucose, ammonia, cortisol, testosterone, and the testosterone/cortisol ratio in the blood. Results: The findings were as follows: (1) HBO can lower the activity of CK in the blood after exhaustive exercise. (2) HBO can significantly control the rise of ammonia after exhaustive exercise. (3) HBO does not immediately lower glucose after exhaustive exercise. (4) HBO can effectively lower cortisol after exhaustive exercise. (5) HBO helps increase testosterone after exhaustive exercise. (6) HBO helps increase the testosterone/cortisol ratio in the blood. Based on the findings, this study supports that HBO helps recovery from fatigue after exhaustive exercise.
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Chen, Shih-Bin, and 陳世彬. "The Clinical Role of Hyperbaric Oxygen Therapy in Treatment of Early Diabetic Foot." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/07410172853706889847.
Повний текст джерелаАнотація:
碩士國防醫學院
海底醫學研究所
88
ABSTRACT Diabetic foot is one of the severe complications of diabetes mellitus (DM). Current treatment for diabetic foot is still limited. Adjuvant hyperbaric oxygen (HBO2) is generally accepted as a treatment and appears to be beneficial for the wound healing of diabetic foot. However, HBO2 is clinically used when patient’s diabetic foot condition is in the late stage (ulcer infection combined carious osteomyelitis). Therefore, HBO2 is not clinically used to treat early stage of diabetic foot. This study was done to test the hypotheses that early stage of diabetic foot given HBO2 would heal the wound, improve the neural and vascular function, and prevent the pathologic change. Twenty-nine patients with diabetic foot were selected from Tri-General Hospital between September 1999 and April 2000. Seventeen and twelve patients were assigned to experimental and control groups, respectively. The patients in the control group were treated like the patients in the experimental group in every way except they did not receive the HBO2 intervention. Data collection included demographic data, blood biochemical examinations, neural and vascular function assessment, and clinical evaluation. The time points for data collection were as follows: (1) blood biochemical examinations and clinical evaluation — before the HBO2 treatment, the fifteenth HBO2 treatment, and after the final HBO2 treatment, (2) neural and vascular function assessment -- before the HBO2 treatment and after the final HBO2 treatment. The results of this research indicated that 86% patients were in the early stage (Wagner Grade 0, I, II). Blood biochemical examinations showed the patients in the experimental group had lower white blood count (WBC) after HBO2 treatment, (p < 0.05). Motor nerve conduction studies (MNCS) indicated that the experimental group had significantly higher amplitude in peroneal nerve, tibial nerve and lower vibration perception threshold (VPT) than the control group. Transcutaneous oxygen tension (TcPO2) examinations showed that there were no differences between the experimental and control groups before and in the middle of the HBO2 treatment. However, the experimental group had significantly higher transcutaneous oxygen tension (TcPO2) and higher blood flow of foot than the control group after the HBO2 treatment. HBO2 can promote the neural and vascular function, avoid the pathologic change, and further prevent the damage, ulcer, and infection of diabetic foot. In addition, HBO2 can help the wound healing, prevent severe necrosis, and avoid amputation.
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Mendes, Daniela Maria Martins. "Clinical and molecular effects of hyperbaric oxygen therapy in diabetic foot ulcers healing." Doctoral thesis, 2014. https://repositorio-aberto.up.pt/handle/10216/77891.
Повний текст джерела
40
Mendes, Daniela Maria Martins. "Clinical and molecular effects of hyperbaric oxygen therapy in diabetic foot ulcers healing." Tese, 2014. https://repositorio-aberto.up.pt/handle/10216/77891.
Повний текст джерела
41
Yu, Shi-Yau, and 虞希堯. "Integrative Vascular Medicine:(1)Far-Infrared Light Therapy Increasing Tissue Perfusion;(2)Hyperbaric Oxygenation Increasing Hepatic Ischemic Tolerance." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/94312049912493895071.
Повний текст джерелаАнотація:
博士國立清華大學
分子與細胞生物研究所
94
More than 50% of the populations have used complementary and alternative medicine (CAM) or integrative medicine (IM) at least once. From a functional standpoint, CAM/IM may be defined as interventions neither taught widely in medical schools nor generally available in hospitals. Well-designed medical researches and clinical trials are urgently needed to test the safety and efficacy of CAM/IM. Far-infrared (FIR) light therapy and hyperbaric oxygen (HBO) therapy are two emerging areas of CAM, and get much advances and utilization recently. Skin microcirculation plays an important role in chronic wound healing and hepatic ischemia-reperfusion (I/R) injury is a lethal complication met in transplantation and resection surgeries. The purpose of this study was to validate the role of FIR and HBO in skin microcirculation and hepatic I/R injury. Sixty rats were used in the FIR study. A WSTM TY301 far-infrared emitter was placed 20cm over the rats. Skin temperature and blood flow were continuously measured. Under laboratory control, the abdominal skin temperature steadily increased to 38 to 39°C, and was kept at constant temperature. The results showed that there was no significant change of skin blood flow during FIR treatment. Skin blood flow increased significantly soon after the removal of FIR emitter. The stimulating effect of skin blood flow was more significant in the rats treated with FIR for 45 min and could be sustained as long as 60 min. These findings suggested a non-thermic biological effect of FIR on skin microcirculation. The promotive effect of FIR on increasing skin blood flow was not influenced by pretreatment of APP (atropine, propranolol, phentolamine), but was suppressed by L-NAME (an eNOS inhibitor) pretreatment. In conclusion, FIR therapy exerts a NO-related biological effect to increase skin microcirculation in rats. This might bring into perspective the clinical application of FIR to treat ischemic disease by augmenting L-arginine/NO pathway. Daily treatment with one dose-HBO (90 minutes, 2.5ATA) was brought about for male Spraque-Dawley rats for one to three days before an I/R injury of liver. Hepatic expression of heat-shock protein 70 (Hsp70), total concentration of glutathione (GSH), activity of catalase, superoxide dismutase (SOD) and serum AST and ALT were estimated before and after HBO, as well as after I/R injury. The results showed that activity of hepatic catalase was decreased by one dose, but not three doses, of HBO as compared with baseline data. However, hepatic Hsp70 expression fluctuated insignificantly. AST and ALT increase less in rats preconditioned with one dose-HBO as compared with those without HBO or with 3 doses-HBO. These results showed preconditioning by one dose-HBO has protective on rat liver against subsequent ischemia-reperfusion injury. The present study is a scientific validation of CAM/IM in vascular medicine. Integrating FIR therapy and HBO therapy into conventional vascular therapies is beneficial to the patients with insufficient microcirculation and hepatic I/R injury.
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Hsu-Hsiao-Ping and 徐曉萍. "Effects of Hyperbaric Oxygen Therapy of Disease Development of (NZBxNZW)F1 Lupus-like Mice." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/98970960672857229467.
Повний текст джерелаАнотація:
碩士國防醫學院
海底醫學研究所
90
Abstract Hyperbaric oxygen (HBO2) has been widely applied as an adjunctive treatment for a variety of medical disorders, such as carbon monoxide poisoning, decompression sickness, air embolism, chronic osteomyelitis, and burn injuries. The principal known mechanisms of HBO2 are that it increases oxygen concentration in the blood supply, changes the blood flow to the abnormal area, increases the flexibility of red cells, and reduces tissue edema. The effects of HBO2 on the immune system are controversial. Recent studies showed that HBO2 exposure produced changes in the immune system, including lymphocyte redistribution and decreased lymphocyte proliferation. The suppressive function of HBO2 on the immune system might be suggested to be applicable for the treatment of certain autoimmune diseases and allograft rejection problems. System lupus erythematosus (SLE) is a chronic autoimmune disease that generally affects young women. It is characterized by large numbers of autoreactive lymphocytes reacting to self-antigens. The resulting formation of immune complexes can deposit in tissue and activate the complement cascade. Eventually inflammation causes various forms of tissue damage. Murine SLE, which provides a good model of human SLE, has been used to study the pathogenesis of this disease. In this study we used the (NZBxNZW) F1 mice, the unique lupus prone hybrid, to evaluate the effects of HBO2 therapy on autoimmune diseases. The mice were divided into 4 groups. 3 groups of mice were treated with HBO2 at 2.5 ATA for 90 min daily over 2 weeks starting from different age of 3-month-old, 6-month-old, 8-month-old, respectively: A (mice given HBO2 protocol at 3-, 6-, and 8-months-old); B (mice given HBO2 protocol at 6- and 8-months-old); C (mice given HBO2 protocol at 8-month-old); D (control group).Our results show that: (1) HBO2 decreases the percentage of positive proteinuria (>2+) in groups A and B and increases their survival rate; (2) HBO2 reduces the anti-dsDNA IgG antibodies titer in groups A and B; (3) HBO2 changes the distribution of lymphocytes in groups A and B (the percentage of CD3+ [T lymphocyte] is decreased, the CD19+ [B lymphocyte] is increased, the subset of T lymphocytes [CD4+] is decreased); (4) groups A and B have less anti-dsDNA IgG immuno-complex deposition and less brightness in the glomerulus. HBO2 improves the disease expression of (NZBxNZW) F1 in groups A and B mice given the HBO2 protocol at early (3-month-old) and middle (6-month-old) stages of lupus development. Group C mice given the HBO2 protocol at the late stage (8-month-old) of disease development showed no significant beneficial effect.
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Tsai, Na Hui, and 蔡娜慧. "Factors Related to Self-Care Behavior in Hyperbaric Oxygen Therapy Patients with Diabetes Mellitus." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/70083792450417471995.
Повний текст джерелаАнотація:
碩士長庚大學
護理學系
102
Objectives: Hyperbaric oxygen therapy (HBOT) is commonly used to treat patients with diabetic foot. About 30% of the disease treated with HBOT are diabetic foot, to preventing complications, tight glycemic control and self- care behavior has been emphasized .The purpose of this proposal wasto identify the self–care behavior in HBOT-treated patients with diabetes. Method: A cross-sectional , correlational design was used in HBOT patients with diabetes in a southern Taiwan Hospital. The research instruments were as follows: a demographic sheet, Family support, knowledge of Diabetes, self-efficacyscale, Diabetes self-care behavior. Result:1. According to each subscale , the diet self-care scale had the highest standardized score. While the exercise self-care scale had the lowest standardized coefficient 2. Regression analyses demonstrated indicate that a combination of “Family support”, “educational level” and “self-efficacy” explained 74% of variability of self-care behavior in HBOT-treated patients with diabetes. Among variable, “self-efficacy” was the most powerful predictor , which explained 52% of the variability . Conclusion: The results of the study improved the understanding of HBOT-treated patients with diabetes perspective forcare-giver.Therefore, strategies to enhance self-efficacy and self-care behaviors for patients are important of diabetes education programs. Key words: HBOT, Self-care behavior, Self efficacy, Family support, Diabetes melllitus
44
HSU, CHING-YUN, and 許競云. "To investigate the possible molecular mechanism of autophagy in hyperbaric oxygen therapy in cancer." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/c86dvq.
Повний текст джерелаАнотація:
碩士國防醫學院
微生物及免疫學研究所
106
Hyperbaric oxygen treatment (HBOT) for invasive cancer has long been considered to be contraindicated since HBOT might enhance tumor growth. However, in the oxygen deficit condition, some tumor cells become more progressive and such hypoxic cells might have potentials to be metastatic. Therefore, it is highly skeptical that HBO treatment increasing oxygen partial pressure might cause tumor suppression. Lung cancers refer to the primary malignant epithelial tumors in the trachea, bronchus and lungs. It mainly divides into two categories: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). Because the prognosis of advanced lung cancer is very poor, there are many studies trying to find effective treatment for lung cancers. Autophagy plays a complicated role in cancers, it might suppress or promote cancer cells proliferation at different stages or situations. It believes that tumor suppression might be due to inducing cell death by autophagic apoptosis pathway. Therefore, to take the advantage of autophagy could develop a novel method for cancer therapy. Our experimental model used adenocarcinoma cells of lung (A549 cell line) to explore whether hyperbaric oxygenation would induce autophagic apoptosis. The results showed that after HBO treatment, the proliferation of cells in the HBO treated group were inhibited and showed more expression of autophagy-related proteins. Therefore, we hypothesize that HBO treatment would change the hypoxic microenvironment then inducing autophagic apoptosis and suppress tumor growth.
45
Lin, Li-Chen, and 林利珍. "Effects of hyperbaric oxygen therapy on the quality of life in patient with problem wound." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/87538127497226226290.
Повний текст джерелаАнотація:
碩士國防醫學院
護理研究所
90
Distress and unknown prognosis related to problem wound not only limited the patient's regular mobility but also damaged the patient's quality of life. Hyperbaric oxygen treatment (HBO2Tx)can significantly increase tissue oxygenation and promote wound healing, then improve the patient's quality of life. The purpose of this study was to investigate the effect of HBO2Tx on quality of life in patient with problem wound. The study is a longitudinal prospective design. Patients with problem wound are selected from one teaching hospital in Taipei, Taiwan by the convenience sampling during five-month (from Dec 2001 to May 2002). Questionnaires used in this study included a demographic data sheet, wound scoring system, blood examination data and quality of life index (QLI). Date are collected on two occasions（pre- HBO2Tx , one week after completion of the HBO2Tx day）. Data analyzed by arithmetic mean, standard deviation, percentage, paired-t test, oneway ANOVA and multiple regression from SPSS Window 10.0. P＜0.05 is considered statistically significant. The major finding of this study were as follows： 1、 Generally speaking, patient with problem wound (n=15) before HBO2Tx had above medium quality of life(mean score was 17.56). The mean score of the close factor dimension subscale was the highest, health subscale was the lowest. After HBO2Tx, patient got medium-up quality of life(mean score was 20.75). The mean score of the close factor dimension subscale was the highest, the psychosocial subscale was the lowest. 2、 The quality of life had no difference in term of gender, age, marital status, education, religion, time of wound happen(p>0.05). 3、 After HBO2Tx, the quality of life was positively correlated significant with Strauss’s wound scope system (p<0.05). 4、 After HBO2Tx, the quality of life was negatively correlated significant with ESR (p<0.05). 5、 Strauss’s wound scope system and ESR were significant explained the quality of life in patient with problem wound. Both of them explained 79.1% of the variance in quality of life. Strauss’s wound scope system was the strongest predictor of quality of life (67.9%). According to the result of the study, the researcher wound like to provide appropriate clinical nursing practice, education, and study further way, and to promote quality of life in patient with problem wound. In conclusion, the quality of life in patient with problem wound was improved after HBO2Tx.
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Shih-Jen and 陳識仁. "Effects of hyperbaric oxygen therapy on serum cytokines in patients with type 2 diabetes mellitus." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/85236430961914527512.
Повний текст джерелаАнотація:
碩士中山醫學大學
醫學研究所
95
Background: The potential benefits of hyperbaric oxygen therapy (HBOT) have been reported in diabetic patients with foot ulcers. However, the roles of HBOT on wound healing-associated growth factors and inflammatory mediators are not completely understood in diabetes mellitus (DM). Objectives: The aim of this study was to investigate the effects of HBOT on circulating cytokines, NO, and insulin-like growth factors (IGFs) in patients with type 2 DM. Design and methods: Serum samples were collected from patients with type 2 DM (n=31) and healthy subjects (n=29) before (baseline) and after the first and third exposure. Results: Before HBOT, body mass index (BMI) and serum HbA1c were significantly greater, whereas serum IGF-I was significantly lower in diabetic patients compared to healthy subjects (one-way ANOVA, p<0.05). After adjusting for age, gender, and BMI, serum insulin, growth hormone (GH), IGF-II, IGF-binding protein (IGFBP)-1, IGFBP-3, leptin, interleukin (IL)-8, and NO were not significantly altered by HBOT in diabetic patients and healthy subjects (repeated-measures ANOVA). Change in serum insulin (baseline to the third exposure) was a positive predictor of changes in leptin and NO in healthy subjects and diabetic patients, respectively. Conclusions: Our results suggest that short-term HBOT may not alter the circulating insulin, IGF, leptin, IL-8, and NO levels. Further studies are needed to clarify the mechanism of HBOT-improved wound healing in diabetic patients with foot ulcers.
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Chen, Chenyu, and 陳貞佑. "Hyperbaric Oxygen Therapy In Treatment Of Diabetic Foot Ulcers And Improvement of Quality Of Life." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/82090733176752109773.
Повний текст джерелаАнотація:
碩士義守大學
管理學院管理碩士在職專班
100
Diabetic foot was the most common complication in diabetic patients. Clinical treatment on diabetic foot was mainly traditional medicine and surgical operation. Hyperbaric oxygen therapy (HBOT) is a complementary medicine, and may be effective for diabetic foot. It can restrain the growing of bacteria and the activation of its toxins, increase oxygen diffusion to wounded tissues, control wound infection, and come to the effect of wound healing to diminish the necessity of diabetic foot amputation. Adequate treatment is essential for patients with diabetic foot, and, may be able to avoid physical and psychological suffering for them and, thus, improves quality of life. The main purpose of this study was to investigate the effects of hyperbaric oxygen therapy on inflammation index, blood glucose, wound healing, change of blood flowing in wounded limb, change of bacterial species cultivated at wound and quality of life among patients with diabetic foot. This was a quasi-experimental clinical study. The patients enrolled in this study had diagnosed diabetic foot, and were hospitalized in a medical center in Southern Taiwan from June, 2011 to April, 2012. A total of 38 patients were recruited, and then assigned to either the experimental group (n=20) or the control group (n=18). Patients in the experimental group received 20 sessions hyperbaric oxygen therapy. Each session lasted 120 minutes. The control group received routine care. Measurements included structural questionnaire (the Medical Outcome Study 36-Item Short-form Health Survey, SF-36), wound evaluation, blood biochemical indices (ESR, CRP, and HbAlc), bacteria collected from wound site for cultivation, and the testing of blood flowing in wounded limb by Doppler image system. Data were collected at just before the HBOT (T1), the 10th HBOT (T2), the 20th HBOT (T3), and 2 weeks after the final session of HBOT (T4). Descriptive and inferring statistic analyses with a significant difference p< 0.05 were utilized. The results showed that for the “wound physiological indices-wound grade”, wounds were significantly improved at T3 in experimental group; while wounds were deteriorated at T2 in the control group. The amputation rate was 5% in experimental group, and 11% in the control group. The wounds at T4 had significant difference (p< .001) between two groups. For “wound physiological indices-blood flowing test”, the data proved that the concentrations of ESR, CRP, HbAlc were improved to 54.78 %, 78.11%, 23.05% from T1 to T4 respectively. The blood flow increased for diabetic foot in the experimental group. Contrary, the concentration of CRP raised 6.54% in the control group. Hence it was proved that the inflammation index and blood glucose could be controlled, and improved by HBOT, and its stability could still be noted 2 weeks after therapy. For “wound physiological indices- bacteria culture”, Proteus.mirabilis and Staph. aureus existed repeatedly from T1 to T4 both in experimental group and control group. Therefore, these two bacterial strains were found to have influence on wound at diabetic foot. However, the growing of the two bacterial strains descended from 5 to 2 and 7 to 1 in the experimental group at T4, respectively; while they were from 7 to 8 and 4 to 4 in the control group. The “wound physiological indices- wound grade” and “quality of life” in both two groups presented positive correlation. Yet the noticeable difference (p<.001) was only found in the experimental group. The physical component summary (PCS) showed a negative correlation between “wound physiological indices-blood test” and “quality of life”, in both groups. The mental component summary (MCS) showed a negative correlation in the experimental group, and a positive correlation in the control group. Quality of life in two groups came to different changes from T2. The scoring of PCS and MCS significantly improved and maintained to T4 in the experimental group; while they started to present a tendency of gliding when at T2 in the control group. Furthermore, there were notable improvements in physical function (PF), role limitation due to physical problems(RP), body pain (BP), and general health (GH) from T2 ( p< .05) in the experimental group, and these four dimensions maintained significant level also from T3 to T4. The scores of role limitation due to emotional problems (RE) and vitality (VT) in experimental group were lower than those in control group (p< .05) at T1, but they showed significant differences (p< .05) at T2, and they maintained significant level at T3 and T4. In addition, the effect of HBOT did not show significant difference (p=.195) at T2 in social function (SF) in the experimental group; while it improved remarkably after T3 comparing with the control group (p< .001). The scores at T2 in mental health (MH) had reached significant level (p< .05) in the experimental group. This study proved that HBOT could improve diabetic foot ulcer, and promote quality of life. Twenty sessions HBOT is an important watershed according to our study results. As this study proved that the wound grade and inflammation index were controlled, and improved when undergoing HBOT from T3 in the experimental group, and that relatively reduced patients’ physical and mental wound and persecution. Meanwhile, we found that quality of life for patients with diabetic foot, PCS and MCS presented a remarkable change from T2 and the greatest effect was found at T3. Therefore, 20 sessions of HBOT is recommended for treatment of diabetic foot.
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Chen, Chia-Ling, and 陳佳伶. "The Effect Analysis Of Hyperbaric Oxygen Therapy For Carbon Monoxide Intoxication：A Medical Center In Kaohsiung." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/83361763253647440005.
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碩士義守大學
管理學院管理碩士在職專班
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The aim of this study is to investigate the effect of hyperbaric oxygen therapy on carbon monoxide poisoning patients. Glasgow coma scale (GCS), severity of poisoning, sessions of treatment and time intervals between carbon monoxide poisoning and hyperbaric oxygen therapy are parameters for investigating the effect of hyperbaric oxygen therapy. The result of this study will improve the understanding of hyperbaric oxygen therapy and clinical management in carbon monoxide poisoning patients. The hyperbaric oxygen therapy was performed under 2.5 absolute atmospheric pressure (ATA) for 90 minutes once daily. From January of 2011 to December of 2012, 15 patients suffered from carbon monoxide poisoning treated with hyperbaric oxygen are enrolled as study group. The other 13 patients suffered from carbon monoxide poisoning who did not receive hyperbaric oxygen therapy are enrolled as control group. Suicide with charcoal burning is the major cause of poisoning in both groups. The average age in study group is 40.07 years old and 40.15 years old in control group. The GCS improves from 9.2 to 14.4 after hyperbaric oxygen therapy in study group and the GCS improves from 11.77 to 14.85 in control group. From our study, the intervals between carbon monoxide poisoning to hyperbaric oxygen therapy is important in recovery from carbon monoxide poisoning. Delay for one single day from poisoning will significantly decrease the GCS for 0.049 (p<0.05). In the mild poisoning group ( COHb 10-30% ), the intervals between poisoning and hyperbaric oxygen therapy also decrease the GCS for 0.067. In the moderate poisoning group ( COHb 31-40%), delay for hyperbaric oxygen therapy will significantly deteriorate the GCS for 0.377 (p<0.05). In conclusion, early intervention with hyperbaric oxygen will improve the recovery from acute carbon monoxide poisoning.
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Cheng-WeiHuang and 黃政維. "Hyperbaric oxygen therapy ameliorates Alzheimer’s disease-mediated cognitive deficits and mood disorders by enhancing autophagy." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/v5bbty.
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楊春勇. "Hyperbaric Oxygen Therapy and Exercise for Acute Medial Collateral Ligament Injury on New Zealand White Rabbits." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/45711747839627015716.
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