Добірка наукової літератури з теми "Hydrogen Bond Surrogate"
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Статті в журналах з теми "Hydrogen Bond Surrogate"
Sawyer, Nicholas, та Paramjit S. Arora. "Hydrogen Bond Surrogate Stabilization of β-Hairpins". ACS Chemical Biology 13, № 8 (13 липня 2018): 2027–32. http://dx.doi.org/10.1021/acschembio.8b00641.
Повний текст джерелаJoy, Stephen T., та Paramjit S. Arora. "An optimal hydrogen-bond surrogate for α-helices". Chemical Communications 52, № 33 (2016): 5738–41. http://dx.doi.org/10.1039/c6cc01104g.
Повний текст джерелаReddy, Sravanthi S., Sunit Pal, Sudip Ghosh та Erode N. Prabhakaran. "Hydrogen Bond Surrogate‐Constrained Dynamic Antiparallel β‐Sheets". ChemBioChem 22, № 12 (20 травня 2021): 2111–15. http://dx.doi.org/10.1002/cbic.202100028.
Повний текст джерелаSawyer, Nicholas, and Paramjit S. Arora. "Using Hydrogen Bond Surrogate Technology to Stabilize Beta-Hairpins." Biophysical Journal 112, no. 3 (February 2017): 177a. http://dx.doi.org/10.1016/j.bpj.2016.11.979.
Повний текст джерелаDimartino, Gianluca, Deyun Wang, Ross N. Chapman та Paramjit S. Arora. "Solid-Phase Synthesis of Hydrogen-Bond Surrogate-Derived α-Helices". Organic Letters 7, № 12 (червень 2005): 2389–92. http://dx.doi.org/10.1021/ol0506516.
Повний текст джерелаMiller, Stephen E., Neville R. Kallenbach та Paramjit S. Arora. "Reversible α-helix formation controlled by a hydrogen bond surrogate". Tetrahedron 68, № 23 (червень 2012): 4434–37. http://dx.doi.org/10.1016/j.tet.2011.12.068.
Повний текст джерелаWang, Deyun, Kang Chen, Gianluca Dimartino та Paramjit S. Arora. "Nucleation and stability of hydrogen-bond surrogate-based α-helices". Org. Biomol. Chem. 4, № 22 (2006): 4074–81. http://dx.doi.org/10.1039/b612891b.
Повний текст джерелаSawyer, Nicholas, and Paramjit S. Arora. "Hydrogen Bond Surrogate Beta-Hairpins to Inhibit Protein-Protein Interactions." Biophysical Journal 114, no. 3 (February 2018): 56a—57a. http://dx.doi.org/10.1016/j.bpj.2017.11.362.
Повний текст джерелаLiu, Junyang, Shoubin Tang, Jia-Lei Yan, and Tao Ye. "Design and Synthesis of Novel Helix Mimetics Based on the Covalent H-Bond Replacement and Amide Surrogate." Molecules 28, no. 2 (January 12, 2023): 780. http://dx.doi.org/10.3390/molecules28020780.
Повний текст джерелаWang, Deyun, Min Lu та Paramjit S Arora. "Inhibition of HIV-1 Fusion by Hydrogen-Bond-Surrogate-Based α Helices". Angewandte Chemie International Edition 47, № 10 (22 лютого 2008): 1879–82. http://dx.doi.org/10.1002/anie.200704227.
Повний текст джерелаДисертації з теми "Hydrogen Bond Surrogate"
Nallapati, Lakshmi Aparna. "Design and Synthesis of Peptidomimics Constrained in Helical and Sheet Conformations using a Novel Covalent Surrogate for the Peptide Main Chain Hydrogen Bond." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/3867.
Повний текст джерелаNallapati, Lakshmi Aparna. "Design and Synthesis of Peptidomimics Constrained in Helical and Sheet Conformations using a Novel Covalent Surrogate for the Peptide Main Chain Hydrogen Bond." Thesis, 2015. http://etd.iisc.ernet.in/2005/3867.
Повний текст джерелаPal, Sunit. "Design, Synthesis and Conformational Analysis of Hydrogen Bond Surrogate (HBS) Stabilized Helices in Natural Sequences. Helically Constrained Peptides for Potential DNA-Binding." Thesis, 2020. https://etd.iisc.ac.in/handle/2005/4837.
Повний текст джерелаCSIR
Kuo, Li-Hung, та 郭禮閎. "Effect of Lysine Side Chain Length at Non-Hydrogen Bonded Strand Positions on β-Hairpin Stability and Toward Introducing a Hydrogen Bond Surrogate at the N-Terminus of Rev Peptide on RNA Recognition". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/35294568871900306564.
Повний текст джерела國立臺灣大學
化學研究所
101
There are many factors that contribute to protein folding and structure stability: intrinsic propensity of amino acids, side chain ion pairing interaction, hydrophobic effect, hydrogen bonding, van der Waals interaction. In this study, we focused on the effect of lysine side chain length on sheet propensity at a non-hydrogen bonded strand position in β-hairpin. The β-hairpin peptides HPTAlaXaa (Xaa= Dap, Dab, Orn, Lys) were designed with the side chain of Lys9 systematically shortened to investigate the effect of Lys side chain length on sheet propensity. The peptides were synthesized by solid phase peptide synthesis using Fmoc-based chemistry. All peptides were purified to 95% purity and were analyzed by 2D NMR experiments. Sequence specific assignment was performed. The hairpin structures were confirmed by chemical shift deviation, 3JHNα coupling constants,and NOE signals.The fraction folded and ΔG of peptides were derived by comparing the chemical shifts with the fully folded and unfolded reference peptides. The percent folding of HPTAlaXaa peptides with Lys analogs at the guest position followed the trend: HPTAlaDap ~ HPTAlaDab < HPTAlaOrn ~ HPTAlaLys, showing that the longer the Lys analogue side chain, the more stable the β-haiprin structure. The HIV Rev protein binds RRE RNA to regulate the transport of unspliced and spliced mRNA from the nucleus to the cytoplasm posttranscriptionally. The Rev peptide is a random-coil. However, the conformation of the Rev peptide changes to an α-helix while binding to RRE RNA. Hydrogen bond surrogate (HBS) is one of the several cross-linking systems for stabilizing an α-helix, using the covalent bond C=C-C-N to substitute the C=O…H-N (i, i+4) hydrogen bond in a short helix. In order to synthesize an HBS peptide, strategy for synthesis of dipeptides that contained an allyl group on the amino group was designed and refined. Two wild type Rev peptides were synthesized by solid phase peptide synthesis using Fmoc-based chemistry. The secondary structure of the two peptides was random-coil analyzed by circular dichroism spectroscopy. The binding specificity of the Rev peptides was determined by gel shift assay. The dissociation constants of the Rev peptides were similar to previous studies.
Gupta, Sunil K. "Nature of Local Interactions at cisPro-Aro Peptide Sequences in Proteins : Evidences for van der Waals type Interactions. Design and Synthesis of Novel Covalent Surrogates for the Peptide Hydrogen Bond." Thesis, 2016. http://etd.iisc.ac.in/handle/2005/2859.
Повний текст джерелаGupta, Sunil K. "Nature of Local Interactions at cisPro-Aro Peptide Sequences in Proteins : Evidences for van der Waals type Interactions. Design and Synthesis of Novel Covalent Surrogates for the Peptide Hydrogen Bond." Thesis, 2016. http://etd.iisc.ernet.in/handle/2005/2859.
Повний текст джерелаЧастини книг з теми "Hydrogen Bond Surrogate"
Yoo, Daniel, and Paramjit S. Arora. "CHAPTER 6. Hydrogen Bond Surrogate Stabilized Helices as Protein–Protein Interaction Inhibitors." In Protein–Protein Interaction Regulators, 124–46. Cambridge: Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781788016544-00124.
Повний текст джерелаJedhe, Ganesh S., and Paramjit S. Arora. "Hydrogen bond surrogate helices as minimal mimics of protein α-helices." In Synthetic and Enzymatic Modifications of the Peptide Backbone, 1–25. Elsevier, 2021. http://dx.doi.org/10.1016/bs.mie.2021.04.007.
Повний текст джерелаТези доповідей конференцій з теми "Hydrogen Bond Surrogate"
Kushal, Swati, Brooke Bullock, Laura Henchey, Paramjit Arora, and Bogdan Olenyuk. "Abstract 289: Hydrogen bond surrogate (HBS) helices as orthosteric regulator of hypoxia inducible transcription." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-289.
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