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Статті в журналах з теми "Hybrid nanoconstruct"

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Автор: Grafiati

Опубліковано: 14 березня 2023

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1

Nguyen, Tuyen Duong Thanh, Arunkumar Pitchaimani, Colin Ferrel, Ravindra Thakkar, and Santosh Aryal. "Nano-confinement-driven enhanced magnetic relaxivity of SPIONs for targeted tumor bioimaging." Nanoscale 10, no. 1 (2018): 284–94. http://dx.doi.org/10.1039/c7nr07035g.

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We uniquely engineered targeted hybrid nanoconstruct (HNC) made up of PLGA and superficially decorated with bone targeting agent, alendronic acid, whose inner polymeric core is confined with 5 nm SPIONs by tuning the distance between the clustering SPIONs. Effect of such cluster confinement in the magnetic properties of HNC was studied in detail.

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2

Nair, Lakshmi V., Yutaka Nagaoka, Toru Maekawa, D. Sakthikumar, and Ramapurath S. Jayasree. "Quantum Dot Tailored to Single Wall Carbon Nanotubes: A Multifunctional Hybrid Nanoconstruct for Cellular Imaging and Targeted Photothermal Therapy." Small 10, no. 14 (April 1, 2014): 2771–75. http://dx.doi.org/10.1002/smll.201400418.

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3

Nimi, N., Ariya Saraswathy, Shaiju S. Nazeer, Nimmi Francis, Sachin J. Shenoy, and Ramapurath S. Jayasree. "Multifunctional hybrid nanoconstruct of zerovalent iron and carbon dots for magnetic resonance angiography and optical imaging: An In vivo study." Biomaterials 171 (July 2018): 46–56. http://dx.doi.org/10.1016/j.biomaterials.2018.04.012.

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4

Nair, Lakshmi V., Yutaka Nagaoka, Toru Maekawa, D. Sakthikumar, and Ramapurath S. Jayasree. "Quantum Dots: Quantum Dot Tailored to Single Wall Carbon Nanotubes: A Multifunctional Hybrid Nanoconstruct for Cellular Imaging and Targeted Photothermal Therapy (Small 14/2014)." Small 10, no. 14 (July 2014): 2964. http://dx.doi.org/10.1002/smll.201470085.

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5

Cauda, Valentina. "Stimuli-responsive hybrid nanoconstructs for efficient theranostic applications in nanomedicine." Project Repository Journal 15, no. 1 (November 7, 2022): 44–47. http://dx.doi.org/10.54050/prj1519538.

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Stimuli-responsive hybrid nanoconstructs for efficient theranostic applications in nanomedicine The multidisciplinary ERC Starting Grant project “Hybrid immune-eluding nanocrystals as smart and active theranostic weapons against cancer” (TrojaNanoHorse) and the following ERC Proof-of-Concept Grant aim to develop a new generation of multifunctional theranostic nanosystems and apply them for improved cancer treatment, efficient cell imaging and for providing high safety for the hosting organism.

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6

Deyev, S. M., and E. N. Lebedenko. "Targeted Bifunctional Proteins and Hybrid Nanoconstructs for Cancer Diagnostics and Therapies." Molecular Biology 51, no. 6 (November 2017): 788–803. http://dx.doi.org/10.1134/s002689331706005x.

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7

Dimitrov, Erik, Natalia Toncheva-Moncheva, Pavel Bakardzhiev, Aleksander Forys, Jordan Doumanov, Kirilka Mladenova, Svetla Petrova, Barbara Trzebicka, and Stanislav Rangelov. "Original Synthesis of a Nucleolipid for Preparation of Vesicular Spherical Nucleic Acids." Nanomaterials 12, no. 20 (October 18, 2022): 3645. http://dx.doi.org/10.3390/nano12203645.

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Spherical nucleic acids (SNAs)—nanostructures, consisting of a nanoparticle core densely functionalized with a shell of short oligonucleotide strands—are a rapidly emerging class of nanoparticle-based therapeutics with unique properties and specific applications as drug and nucleic acid delivery and gene regulation materials. In this contribution, we report on the preparation of hollow SNA nanoconstructs by co-assembly of an originally synthesized nucleolipid—a hybrid biomacromolecule, composed of a lipidic residue, covalently linked to a DNA oligonucleotide strand—with other lipids. The nucleolipid was synthesized via a click chemistry approach employing initiator-free, UV light-induced thiol-ene coupling of appropriately functionalized intermediates, performed in mild conditions using a custom-made UV light-emitting device. The SNA nanoconstructs were of a vesicular structure consisting of a self-closed bilayer membrane in which the nucleolipid was intercalated via its lipid–mimetic residue. They were in the lower nanometer size range, moderately negatively charged, and were found to carry thousands of oligonucleotide strands per particle, corresponding to a grafting density comparable to that of other SNA structures. The surface density of the strands on the bilayer implied that they adopted an unextended conformation. We demonstrated that preformed vesicular structures could be successfully loaded with either hydrophilic or hydrophobic dyes.

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8

Stigliano, Cinzia, Maricela R. Ramirez, Jaykrishna V. Singh, Santosh Aryal, Jaehong Key, Elvin Blanco, and Paolo Decuzzi. "Methotraxate-Loaded Hybrid Nanoconstructs Target Vascular Lesions and Inhibit Atherosclerosis Progression in ApoE−/−Mice." Advanced Healthcare Materials 6, no. 13 (April 12, 2017): 1601286. http://dx.doi.org/10.1002/adhm.201601286.

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9

Brogan, Alex P. S., Richard B. Sessions, Adam W. Perriman, and Stephen Mann. "Molecular Dynamics Simulations Reveal a Dielectric-Responsive Coronal Structure in Protein–Polymer Surfactant Hybrid Nanoconstructs." Journal of the American Chemical Society 136, no. 48 (November 20, 2014): 16824–31. http://dx.doi.org/10.1021/ja507592b.

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10

El-Boubbou, Kheireddine, O. M. Lemine, and Daniel Jaque. "Synthesis of novel hybrid mesoporous gold iron oxide nanoconstructs for enhanced catalytic reduction and remediation of toxic organic pollutants." RSC Advances 12, no. 55 (2022): 35989–6001. http://dx.doi.org/10.1039/d2ra05990h.

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Development of highly-efficient, rapid, and recyclable hybrid mesoporous Au–IO NPs nanocatalysts for elimination of toxic environmental contaminants. Thanks to synergistic cooperation of their well-dispersed AuNPs, large surface area/pore volume, and mesoporosity.

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11

Yakavets, Ilya, Henri-Pierre Lassalle, Dietrich Scheglmann, Arno Wiehe, Vladimir Zorin, and Lina Bezdetnaya. "Temoporfin-in-Cyclodextrin-in-Liposome—A New Approach for Anticancer Drug Delivery: The Optimization of Composition." Nanomaterials 8, no. 10 (October 18, 2018): 847. http://dx.doi.org/10.3390/nano8100847.

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The main goal of this study was to use hybrid delivery system for effective transportation of temoporfin (meta-tetrakis(3-hydroxyphenyl)chlorin, mTHPC) to target tissue. We suggested to couple two independent delivery systems (liposomes and inclusion complexes) to achieve drug-in-cyclodextrin-in-liposome (DCL) nanoconstructs. We further optimized the composition of DCLs, aiming to alter in a more favorable way a distribution of temoporfin in tumor tissue. We have prepared DCLs with different compositions varying the concentration of mTHPC and the type of β-cyclodextrin (β-CD) derivatives (Hydroxypropyl-, Methyl- and Trimethyl-β-CD). DCLs were prepared by thin-hydration technique and mTHPC/β-CD complexes were added at hydration step. The size was about 135 nm with the surface charge of (−38 mV). We have demonstrated that DCLs are stable and almost all mTHPC is bound to β-CDs in the inner aqueous liposome core. Among all tested DCLs, trimethyl-β-CD-based DCL demonstrated a homogenous accumulation of mTHPC across tumor spheroid volume, thus supposing optimal mTHPC distribution.

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12

Patil, Avinash J., Mei Li, and Stephen Mann. "Integrative self-assembly of functional hybrid nanoconstructs by inorganic wrapping of single biomolecules, biomolecule arrays and organic supramolecular assemblies." Nanoscale 5, no. 16 (2013): 7161. http://dx.doi.org/10.1039/c3nr02796a.

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13

Mohamed, M. Sheikh, Srivani Veeranarayanan, Ankur Baliyan, Aby Cheruvathoor Poulose, Yutaka Nagaoka, Hiroaki Minegishi, Seiki Iwai, et al. "Structurally Distinct Hybrid Polymer/Lipid Nanoconstructs Harboring a Type-I Ribotoxin as Cellular Imaging and Glioblastoma-Directed Therapeutic Vectors." Macromolecular Bioscience 14, no. 12 (September 2, 2014): 1696–711. http://dx.doi.org/10.1002/mabi.201400248.

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14

Boca, Sanda, Dumitrita Rugina, Adela Pintea, Nicolae Leopold, and Simion Astilean. "Designing Gold Nanoparticle-Ensembles as Surface Enhanced Raman Scattering Tags inside Human Retinal Cells." Journal of Nanotechnology 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/961216.

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Apart from the traditional development of surface-enhanced raman scattering (SERS) substrates for ultrasensitive spectroscopic analysis, an increasing interest is given nowadays to the design of the so-called SERS nanotags which integrate multiple SERS applications into single plasmonic nanoparticles. The fabrication of SERS tags is still a challenging task due to the complicated fabrication process. Typically, SERS tags are hybrid nanoconstructs consisting in a unique plasmonic nanoobject encoded with specific reporter molecules and enveloped in a protective shell that provides both biocompatibility and targeting function. Herein, we produce effective SERS tags consisting in small aggregates of gold nanoparticles (mainly dimers and trimers) which are captured from solution and then transferred into cells to perform as individual plasmonic nanostructures. Actually the small aggregates formed under controlled conditions are stabilized in solution by interlocking into a polymeric envelope made of thiol-modified poly(ethylene) glycol (PEG-SH). No further encoding operation is necessary in our case since part of ascorbic acid used as reducing agent remains attached in the interparticle junctions, providing persistent and strong SERS signal when the fabricated tags are internalized by human retinal cells. Our studies demonstrate a promising potential of new SERS-active nanoparticles to serve as effective reporters for biomedical tracing and imaging.

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15

Shukla, Ravi Prakash, Jayant Dewangan, Sandeep Urandur, Venkatesh Teja Banala, Monika Diwedi, Shweta Sharma, Sristi Agrawal, Srikanta Kumar Rath, Ritu Trivedi, and Prabhat Ranjan Mishra. "Multifunctional hybrid nanoconstructs facilitate intracellular localization of doxorubicin and genistein to enhance apoptotic and anti-angiogenic efficacy in breast adenocarcinoma." Biomaterials Science 8, no. 5 (2020): 1298–315. http://dx.doi.org/10.1039/c9bm01246j.

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16

He, Chunsheng, Jason Li, Ping Cai, Taksim Ahmed, Jeffrey T. Henderson, Warren D. Foltz, Reina Bendayan, Andrew Michael Rauth, and Xiao Yu Wu. "Two-Step Targeted Hybrid Nanoconstructs Increase Brain Penetration and Efficacy of the Therapeutic Antibody Trastuzumab against Brain Metastasis of HER2-Positive Breast Cancer." Advanced Functional Materials 28, no. 9 (January 8, 2018): 1705668. http://dx.doi.org/10.1002/adfm.201705668.

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17

Dumontel, Bianca, Francesca Susa, Tania Limongi, Veronica Vighetto, Doriana Debellis, Marta Canta, and Valentina Cauda. "Nanotechnological engineering of extracellular vesicles for the development of actively targeted hybrid nanodevices." Cell & Bioscience 12, no. 1 (May 14, 2022). http://dx.doi.org/10.1186/s13578-022-00784-9.

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Abstract Background We propose an efficient method to modify B-cell derived EVs by loading them with a nanotherapeutic stimuli-responsive cargo and equipping them with antibodies for efficient targeting of lymphoma cells. Results The post-isolation engineering of the EVs is accomplished by a freeze–thaw method to load therapeutically-active zinc oxide nanocrystals (ZnO NCs), obtaining the so-called TrojanNanoHorse (TNH) to recall the biomimetism and cytotoxic potential of this novel nanoconstruct. TNHs are further modified at their surface with anti-CD20 monoclonal antibodies (TNHCD20) achieving specific targeting against lymphoid cancer cell line. The in vitro characterization is carried out on CD20+ lymphoid Daudi cell line, CD20-negative cancerous myeloid cells (HL60) and the healthy counterpart (B lymphocytes). The TNH shows nanosized structure, high colloidal stability, even over time, and good hemocompatibility. The in vitro characterization shows the high biocompatibility, targeting specificity and cytotoxic capability. Importantly, the selectivity of TNHCD20 demonstrates significantly higher interaction towards the target lymphoid Daudi cell line compared to the CD20-negative cancerous myeloid cells (HL60) and the healthy counterpart (lymphocytes). An enhanced cytotoxicity directed against Daudi cancer cells is demonstrated after the TNHCD20 activation with high-energy ultrasound shock-waves (SW). Conclusion This work demonstrates the efficient re-engineering of EVs, derived from healthy cells, with inorganic nanoparticles and monoclonal antibodies. The obtained hybrid nanoconstructs can be on-demand activated by an external stimulation, here acoustic pressure waves, to exploit a cytotoxic effect conveyed by the ZnO NCs cargo against selected cancer cells. Graphical Abstract

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18

Villar-Alvarez, E., A. Cambón, A. Pardo, L. Arellano, A. V. Marcos, B. Pelaz, P. del Pino, et al. "Combination of light-driven co-delivery of chemodrugs and plasmonic-induced heat for cancer therapeutics using hybrid protein nanocapsules." Journal of Nanobiotechnology 17, no. 1 (October 15, 2019). http://dx.doi.org/10.1186/s12951-019-0538-3.

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Abstract Background Improving the water solubility of hydrophobic drugs, increasing their accumulation in tumor tissue and allowing their simultaneous action by different pathways are essential issues for a successful chemotherapeutic activity in cancer treatment. Considering potential clinical application in the future, it will be promising to achieve such purposes by developing new biocompatible hybrid nanocarriers with multimodal therapeutic activity. Results We designed and characterised a hybrid nanocarrier based on human serum albumin/chitosan nanoparticles (HSA/chitosan NPs) able to encapsulate free docetaxel (DTX) and doxorubicin-modified gold nanorods (DOXO-GNRs) to simultaneously exploit the complementary chemotherapeutic activities of both antineoplasic compounds together with the plasmonic optical properties of the embedded GNRs for plasmonic-based photothermal therapy (PPTT). DOXO was assembled onto GNR surfaces following a layer-by-layer (LbL) coating strategy, which allowed to partially control its release quasi-independently release regarding DTX under the use of near infrared (NIR)-light laser stimulation of GNRs. In vitro cytotoxicity experiments using triple negative breast MDA-MB-231 cancer cells showed that the developed dual drug encapsulation approach produces a strong synergistic toxic effect to tumoral cells compared to the administration of the combined free drugs; additionally, PPTT enhances the cytostatic efficacy allowing cell toxicities close to 90% after a single low irradiation dose and keeping apoptosis as the main cell death mechanism. Conclusions This work demonstrates that by means of a rational design, a single hybrid nanoconstruct can simultaneously supply complementary therapeutic strategies to treat tumors and, in particular, metastatic breast cancers with good results making use of its stimuli-responsiveness as well as its inherent physico-chemical properties.

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19

Fang, Lei, Hengbo Huang, James D. Quirk, Jie Zheng, Duanwen Shen, Brad Manion, Matthew Mixdorf, et al. "Analysis of Stable Chelate-Free Gadolinium Loaded Titanium Dioxide Nanoparticles for MRI-Guided Radionuclide Stimulated Cancer Treatment." Current Analytical Chemistry 18 (March 21, 2022). http://dx.doi.org/10.2174/1573411018666220321102736.

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Background: Recent studies demonstrate that titanium dioxide nanoparticles (TiO2 NPs) are an effective source of reactive oxygen species (ROS) for photodynamic therapy and radionuclide stimulated dynamic therapy (RaST). Unfortunately, tracking the in vivo distribution of TiO2 NPs noninvasively remains elusive. Objective: Given the use of gadolinium (Gd) chelates as effective contrast agents for magnetic resonance imaging (MRI), this study aims to (1) develop hybrid TiO2-Gd NPs that exhibit high relaxivity for tracking the NPs without loss of ROS generating capacity; and (2) establish a simple colorimetric assay for quantifying Gd loading and stability. Method: A chelate-free, heat-induced method was used to load Gd onto TiO2 NPs, which was coated with transferrin (Tf). A sensitive colorimetric assay and inductively coupled plasma mass spectrometry (ICP-MS) were used to determine Gd loading and stability of the TiO2-Gd-Tf NPs. Measurement of the relaxivity was performed on a 1.4 T relaxometer and a 4.7 T small animal magnetic resonance scanner to estimate the effects of magnetic field strength. ROS was quantified by activated dichlorodihydrofluorescein diacetate fluorescence. Cell uptake of the NPs and RaST were monitored by fluorescence microscopy. Both 3 T and 4.7 T scanners were used to image the in vivo distribution of intravenously injected NPs in tumor-bearing mice. Results: A simple colorimetric assay accurately determined both the loading and stability of the NPs compared with the expensive and complex ICP-MS method. Coating of the TiO2-Gd NPs with Tf stabilized the nanoconstruct and minimized aggregation. The TiO2-Gd-Tf maintained ROS-generating capability without inducing cell death at a wide range of concentrations but induced significant cell death under RaST conditions in the presence of F-18 radiolabeled 2-fluorodeoxyglucose. The longitudinal (r1 = 10.43 mM-1 s -1 ) and transverse (r2 = 13.43 mM-1 s -1 ) relaxivity of TiO2-Gd-Tf NPs were about twice and thrice, respectively, those of clinically used Gd contrast agent (Gd-DTPA; r1 = 3.77 mM-1 s -1 and r2 = 5.51 mM-1 s -1 ) at 1.4 T. While the r1 (8.13 mM-1 s -1 ) reduced to about twice that of Gd-DTPA (4.89 mM-1 s -1 ) at 4.7 T, the corresponding r2 (87.15 mM-1 s -1 ) increased by a factor 22.6 compared to Gd-DTPA (r2 = 3.85). MRI of tumor-bearing mice injected with TiO2-Gd-Tf NPs tracked the NPs distribution and accumulation in tumors. Conclusion: This work demonstrates that Arsenazo III colorimetric assay can substitute ICP-MS for determining the loading and stability of Gd-doped TiO2 NPs. The new nanoconstruct enabled RaST effect in cells, exhibited high relaxivity, and enhanced MRI contrast in tumors in vivo, paving the way for in vivo MRI-guided RaST.

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