Статті в журналах: "HVPDs"

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Berlangieri, Chiara, Elisabetta Andrina, Caterina Matarrese, Emiliano Carretti, Rita Traversi, Mirko Severi, David Chelazzi, Luigi Dei, and Piero Baglioni. "Chelators confined into 80pvac-borax highly viscous dispersions for the removal of gypsum degradation layers." Pure and Applied Chemistry 89, no. 1 (January 1, 2017): 97–109. http://dx.doi.org/10.1515/pac-2016-0815.

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AbstractIn this paper a new method for the removal of gypsum degradation layers from carbonatic matrices in cultural heritage conservation, using aqueous Highly Viscous Polymeric Dispersions (HVPDs) based on partially hydrolyzed poly(vinyl acetate) and borax, embedded with chelators, is presented. Due to their interesting viscoelasticity, these systems guarantee a good adhesion to the treated surface and easiness of removal in one step, minimizing the residues. Thus, they can potentially overcome the “residue question” limit associated to traditional methodologies that use thickened solutions of chelators. Here the rheological properties of HVPDs containing different amounts of selected chelating agents are explored and their efficacy in the extraction of gypsum is verified through cleaning tests onto artificially sulfated travertine tiles. The homogeneous removal of gypsum across the surface was checked non-invasively via Fourier Transform Infrared Spectroscopy (FTIR) 2D Imaging. An analytical protocol for the pre-treatment and the analysis of HVPD samples by means of Ion Cromatography (IC) and Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES) was set up and the approximate amount of calcium sulfate removed was determined.

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Bilek, Furkan, Mehmet Gürhan Karakaya, and İlkim Çıtak Karakaya. "Immediate effects of TENS and HVPS on pain and range of motion in subacromial pain syndrome: A randomized, placebo-controlled, crossover trial." Journal of Back and Musculoskeletal Rehabilitation 34, no. 5 (September 6, 2021): 805–11. http://dx.doi.org/10.3233/bmr-191833.

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BACKGROUND: Transcutaneous electrical nerve stimulation (TENS) is one of the most common methods for managing shoulder pain, and high voltage pulsed currents (HVPS) may be used for reducing pain. However, their immediate effects on resting pain and pain-free active range of shoulder motion (pfROM) in patients with subacromial pain syndrome (SAPS) have not been studied comparatively, yet. OBJECTIVES: The aim of this study was to compare the immediate effects of TENS, HVPS and placebo stimulation on shoulder resting pain and pfROM in patients with SAPS. METHODS: Randomized, placebo-controlled, double-blind, crossover study. One hundred and six patients with SAPS received placebo (predetermined 1st day application), TENS and HVPS with 1-day interval, in a random sequence. Before and after each application, resting pain and pfROM were evaluated by 0–10 cm visual analogue scales and a digital inclinometer, respectively. RESULTS: Intensity of pain decreased significantly after TENS, HVPS and placebo interventions (p< 0.05). While pfROMs increased significantly after TENS and HVPS (p< 0.05), remained unchanged after placebo, except for internal and external rotations (p> 0.05). The most obvious effects on pain and pfROMs occurred after HVPS (p< 0.05). CONCLUSION: In patients with SAPS, both HVPS and TENS, but preferably HVPS can be used effectively to decrease pain and increase pfROM.

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Ponce, Daniela, Welder Zamoner, Fernanda Moreira Freitas, André Balbi, and Linda Awdishu. "Vancomycin Removal during High-Volume Peritoneal Dialysis in Acute Kidney Injury Patients." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 39, no. 2 (March 2019): 183–87. http://dx.doi.org/10.3747/pdi.2018.00092.

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Studies on vancomycin pharmacokinetics in acute kidney injury (AKI) patients on high-volume peritoneal dialysis (HVPD) are lacking. We studied the pharmacokinetics of intravenous (IV) vancomycin in AKI patients treated by HVPD who received a prescribed single IV dose of vancomycin (15 - 20 mg/kg total body weight) to determine the extent of vancomycin removal and to establish vancomycin dosing guidelines for the empirical treatment of AKI patients receiving HVPD. The application of 18 mg/kg vancomycin every 48 - 72 hours in AKI patients undergoing HVPD was required to maintain therapeutic concentrations.

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Shekari Soleimanloo, S., T. Sletten, A. Clark, J. Cori, A. Wolkow, C. Beatty, B. Shiferaw, et al. "P133 Backward Rotating Shifts are Associated with Real-Time Drowsiness During Daytime Drives in Heavy Vehicle Drivers." SLEEP Advances 2, Supplement_1 (October 1, 2021): A64—A65. http://dx.doi.org/10.1093/sleepadvances/zpab014.174.

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Abstract Purpose While 10–20% of heavy vehicle crashes (HVDs) are drowsiness-related, the contributions of subsequent shifts to chronic drowsiness in HVDs is largely unknown. Eye-blink parameters indicate driver drowsiness reliably. This study examined the association of consecutive shifts and real-time drowsiness in HVDs. Methods Habitual sleep-wake of HVDs (all males, aged 49.5 ± 8 years) was monitored objectively (Philips Actiwatch, N=15) for 5 weeks (5.75± 1.4 hours). Johns Drowsiness Score (JDS, a composite eye-blink parameter in one-min intervals) was monitored for 4 weeks in HVDs (N=14) using an infrared oculography (Optalert, Melbourne, Australia) device. We assessed the association of drowsiness events (JDS equal or larger than 2.6) with consecutive shift types via mixed linear regression models. Results Eigth consecutive shifts increased drowsiness by 1.06 times compared to 2 shifts (8.37 events/h vs 6.77 events/h, P= 0.03). Consecutive shift sequences included afternoons (9%), mornings (29%), nights (5%), mixed rotating shifts (28%), forward-rotating shifts (11%) and backward-rotating shifts (12%). Drowsiness event rates were 1.23 times greater during night consecutive shifts relative to afternoon shifts (8.37 events/h vs 6.67 events/h, P= 0.03). Backward-rotating shifts (morning-night-evening- afternoon) elevated daytime drowsiness between 10 am and 3 pm by 1.55 times (10.01 events/h vs 6.47 events/h, P= 0.016). Conclusions Regardless of the number of consecutive shifts, sequential night shifts increase real-time drowsiness in HVDs, with backward rotating shifts resulting in higher rates of drowsiness events during daytime. The interaction of schedule features should inform the work scheduling of HVDs to reduce the risk of drowsiness.

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Shekari Soleimanloo, S., T. Sletten, A. Clark, J. Cori, A. Wolkow, C. Beatty, B. Shiferaw, et al. "P108 Association of drowsiness events with a combination of sleep loss and other work metrics." SLEEP Advances 3, Supplement_1 (October 1, 2022): A65. http://dx.doi.org/10.1093/sleepadvances/zpac029.178.

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Abstract Introduction Heavy vehicle drivers (HVDs), carrying approximately 75% of non-bulk domestic freight on Australian roads, are at risk of drowsiness due to night-time, long drives, or short sleep. Drowsiness comprises 46% of all driver-impairment-related factors in HVDs fatalities. However, the specific role of sleep loss in HVDs' drowsiness is less known. This study assessed the association of sleep loss, independent of other work metrics, with real-time drowsiness in HVDs. Methods Eight HVDs aged 49.8± 8 years, 27± 10.3 years of experience, worked for 3-28 (13± 6) shifts. A composite ocular measure of drowsiness (John's Drowsiness Score) and drivers' sleep-wake was monitored by Optalert glasses and Actiwatches, respectively. The drowsiness event (response variable) was defined as at least one event of JDS≥ 2.6 /h, and sleep loss (exposure) as the variation of sleep opportunity pre-shift from the 9-hour recommended rest break in Europe. Multivariate logistic regression assessed the odds of drowsiness events under sleep loss when adjusted for time of day, shift start time and hours of drive. Results Data comprised 1061 observations of work metrics or JDS and 694 records of sleep duration. Sleep loss ranged from 1 to 6.3 hours (3.4 ± 1.1h). Compared with a 1- 2.5-hour sleep loss, sleep loss> 4 hours doubled the likelihood of drowsiness events when controlled for other covariates (p=0.019). Discussion Sleep loss increases the odds of drowsiness events in HVDs with similar work schedule metrics. Further research should assess if Australia's 7-h minimum break provides adequate sleep under different schedule conditions.

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Ahmed, W., Ed Hungerford, A. MukeherJee, V. Russu, R. Tschirhart, and M. Yucel. "A proposed high voltage distribution system for Mu2e electron tracker." Journal of Instrumentation 17, no. 03 (March 1, 2022): C03039. http://dx.doi.org/10.1088/1748-0221/17/03/c03039.

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Abstract This paper reports on the design and construction of a High Voltage Distribution System (HVDS) for a “Smart Switch” developed to provide high voltage (HV) to a series of stacked straw detector planes in the Mu2e Electron Tracking Detector (ETD). Each plane is composed of three 120 deg. Crescent-shaped panels, and each panel is composed of 96 straw tubes. The HVDS provides HV on-off, current monitoring, recording, and crowbar for over-current protection. The inter-communication system is based on TCP/IP. The HVDS supplies HV with long term stability, and accurately monitors the applied voltage and currents.

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Harris, R., C. Beatty, J. Cori, G. Spitz, S. Soleimanloo, S. Peterson, A. Naqvi, et al. "O066 The Impact of Work Break Characteristics on Sleep Duration in Heavy Vehicle Drivers." SLEEP Advances 3, Supplement_1 (October 1, 2022): A27—A28. http://dx.doi.org/10.1093/sleepadvances/zpac029.065.

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Abstract Introduction Heavy vehicle drivers (HVDs) frequently experience reduced sleep due to travelling long distances under non-standard work hours. Short sleep in HVDs can increase risk of motor vehicle crashes and falling asleep while driving. This study sought to examine the influence of break duration between shifts, break onset time, and prior shift duration on HVDs’ total sleep time (TST) between consecutive work shifts, and the interaction between break duration and break onset time. Methods Twenty-seven HVDs’ sleep and shift work were monitored for up to nine weeks through actigraphy, sleep diaries, and work diaries. Differences in TST between consecutive shifts and days off were assessed. Linear mixed models and pairwise comparisons evaluated the impact of break duration, break onset time, and prior shift duration on TST between shifts. Results TST was significantly lower between consecutive shifts (M=6.38-hours) compared to days off (M=7.63-hours), p<.001. Longer break durations were associated with more TST, p<.001. Break durations up to 7-, 9-, and 11-hours resulted in, on average, 4.76-, 5.66-, and 6.41-hours of sleep, respectively. Breaks starting between 00:01-08:00h led to shorter TST compared to breaks starting between 16:01-20:00h, p<.05. Prior shift duration and the interaction between break duration and break onset time were not associated with TST. Discussion HVDs’ TST between workdays are independently impacted by break duration and break onset time. Break durations between 7-11-hours, reflecting Australian and European break guidelines, result in insufficient sleep. Work regulations must evaluate appropriate break durations and break onset times to allow adequate sleep in HVDs.

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Song, Xiaoming, Lili Miao, Xiaocong Jiao, Musawar Ibrahim, and Jianming Li. "Regulating Vapor Pressure Deficit and Soil Moisture Improves Tomato and Cucumber Plant Growth and Water Productivity in the Greenhouse." Horticulturae 8, no. 2 (February 9, 2022): 147. http://dx.doi.org/10.3390/horticulturae8020147.

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Atmospheric vapor pressure deficit (VPD) is the driving force that regulates the rate of water transport within plants. Under High VPD (HVPD), plants always reduce their photosynthesis rate and close their stomata. Experiments were performed under greenhouse conditions with cucumber and tomato plants to identify the regulatory effect of VPD on plant water capacity. Treatments included two levels of soil water (100% and 60% field capacity [FC]) combined with two levels of VPD (LVPD and HVPD). Results indicated that with 60%FC, the plant heights of tomato and cucumber were enhanced under LVPD compared with those under HVPD. With 60%FC, relative leaf water contents under LVPD increased by 11% compared with those under HVPD. Furthermore, LVPD significantly improved the photosynthetic capacity of the two crops and changed their stress responses. Our results indicated that LVPD at different soil moisture levels reduced irrigation demand under greenhouse conditions. This approach can be applied in water management in greenhouse vegetable production in China and other regions of the world with temperate continental climates.

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Aimola, Lina, Alison R. Lane, Daniel T. Smith, Georg Kerkhoff, Gary A. Ford, and Thomas Schenk. "Efficacy and Feasibility of Home-Based Training for Individuals With Homonymous Visual Field Defects." Neurorehabilitation and Neural Repair 28, no. 3 (September 18, 2013): 207–18. http://dx.doi.org/10.1177/1545968313503219.

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Background. Homonymous visual field defects (HVFDs) are one of the most common consequences of stroke. Compensatory training encourages affected individuals to develop more efficient eye movements to improve function. However, training is typically supervised, which can be time consuming and costly. Objective. To develop and evaluate the efficacy and feasibility of an unsupervised reading and exploration computer training for individuals with HVFDs. Methods. Seventy individuals with chronic HVFDs were randomly assigned to 1 of 2 groups: intervention or control. The former received 35 hours of reading and exploration training, and the latter received 35 hours of control training. Visual and attentional abilities were assessed before and after training using perimetry, visual search, reading, activities of daily living, the Test of Everyday Attention, and a Sustained Attention to Response task. Results. Eighteen individuals failed to complete the training; analyses were conducted on the remaining 28 intervention and 24 control group participants. Individuals in the intervention group demonstrated significant improvements in the primary outcomes of exploration (12.87%, 95% confidence interval [CI] = 8.44% to 17.30%) and reading (18.45%, 95% CI = 9.93% to 26.97%), which were significantly greater than those observed following the control intervention (exploration = 4.80%, 95% CI = 0.09% to 9.51%; reading = 1.95%, 95% CI = −4.78% to 8.68%). Participants in the intervention group also reported secondary subjective improvements, although these were not matched by objective gains in tasks simulating activities of daily living. Conclusions. Home-based compensatory training is an inexpensive accessible rehabilitation option for individuals with HVFDs, which can result in objective benefits in searching and reading, as well as improving quality of life.

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Ginsbury Electronics Ltd. "Mini HVPS drives head-up displays." Displays 10, no. 3 (July 1989): 195. http://dx.doi.org/10.1016/0141-9382(89)90015-2.

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Charczuk, Natalia, Nicole Nowak, and Rafal J. Wiglusz. "Synthesis and Investigation of Physicochemical Properties and Biocompatibility of Phosphate–Vanadate Hydroxyapatite Co-Doped with Tb3+ and Sr2+ Ions." Nanomaterials 13, no. 3 (January 23, 2023): 457. http://dx.doi.org/10.3390/nano13030457.

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Searching for biocompatible materials with proper luminescent properties is of fundamental importance, as they can be applied in fluorescent labeling and regenerative medicine. In this study, we obtained new phosphate–vanadate hydroxyapatites (abbr. HVps) co-doped with Sr2+ and Tb3+ ions via the hydrothermal method. We focused on examining the effect of various annealing temperatures (500, 600 and 700 °C) on the spectroscopic properties and morphology of the obtained HVps. To characterize their morphology, XRPD (X-ray powder diffraction), SEM-EDS (scanning electron microscopy–energy-dispersive spectrometry), FT-IR (Fourier transform infrared) spectroscopy and ICP-OES (inductively coupled plasma–optical emission spectrometry) techniques were used. A further study of luminescent properties and cytocompatibility showed that the obtained HVps co-doped with Sr2+ and Tb3+ ions are highly biocompatible and able to enhance the proliferation process and can therefore be potentially used as fluorescent probes or in regenerative medicine.

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Ponce, Daniela, Cassiana Góes, Mariele Oliveira, and Andre Balbi. "Peritoneal Dialysis for the Treatment of Cardiorenal Syndrome Type 1: A Prospective Brazilian Study." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 37, no. 5 (September 2017): 578–83. http://dx.doi.org/10.3747/pdi.2016.00217.

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This study aimed to explore the role of high-volume peritoneal dialysis (HVPD) in cardiorenal syndrome (CRS) type 1 patients in relation to metabolic and fluid control and outcome. Sixty-four patients were treated by HVPD (prescribed Kt/V = 0.50/session), flexible catheter and cycler. Mean age was 68.8 ± 15.4 years, 54.7% needed intravenous inotropic agents and/or intravenous vasodilators, 31.2% were on mechanical ventilation, acute coronary syndrome (ACS) was the main cause of acute disease heart failure (ADHF) 48.3%, median left ventricular ejection fraction (LVEF) was 38% and the main dialysis indications were uremia and hypervolemia. Blood ureic nitrogen and creatinine levels stabilized after 4 sessions at around 50 and 4 mg/dL, respectively. Negative fluid balance (FB) and ultrafiltration (UF) increased progressively and stabilized around 2.6 L and -2.5 L/day, respectively. Weekly- delivered Kt/V was 3.0 ± 0.42, and 32.8% died. There was a significant difference between the survivors (S) and non-survivors (NS) in age (71.4 ± 15.7 vs 63.6 ± 17.6, p < 0.001), main diagnosis of ADHF (ACS: 76.2 vs 34.8%, p = 0.04), mechanical ventilation (52.4 vs 20.1%, p = 0.03), fluid overload (FO) at predialysis moment (52.4 vs 25.6%, p = 0.04), and FB and UF from the 2ndto 5thdialysis session. In conclusion, HVPD treatment was effective in CRS type 1 patients, allowing adequate metabolic and fluid control. Age, ACS, FO and positive FB after 2 HVPD sessions were higher in NS patients.

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Shekari Soleimanloo, S., T. L. Sletten, A. Clark, J. M. Cori, A. P. Wolkow, C. Beatty, B. Shiferaw, et al. "0286 Schedule Characteristics of Heavy Vehicle Drivers are Associated with Eye-Blink Indicators of Real-Time Drowsiness on the Road." Sleep 43, Supplement_1 (April 2020): A108—A109. http://dx.doi.org/10.1093/sleep/zsaa056.284.

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Abstract Introduction While up to 52% of heavy vehicle crashes are drowsiness-related, the contributions of schedule factors to real-time objective drowsiness in heavy vehicle drivers (HVDs) have not been studied. Eye-blink parameters are a reliable indicator of driver drowsiness. This study aimed to examine the relationship between work-related factors and objective drowsiness in HVDs. Methods HVDs (all males, aged 49.5 ± 8 years) undertook 5- weeks of sleep-wake monitoring (Philips Actiwatch, N=15), and 4-weeks of infrared oculography (Optalert, Melbourne, Australia) to monitor their eye-blink parameters (averaged each minute) while driving their own vehicle (N=12). Participants slept for 5.75± 1.4 hours before the drives. Drowsiness events were defined as any Johns Drowsiness Scores (JDS) scores larger than 2.6 based on prior research. The relationships of schedule factors and drowsiness events per hour were assessed via mixed linear regression models. Results Drowsiness event rates were 3–5 times greater between 22:00 and 03:00 hours compared to between 16:00 and 17:00 hours (17- 25 events/h vs 5 events/h, P= 0.0001 to 0.007). The frequency of drowsiness events at night varied with shift start time and time into shift (P= 0.0001 to 0.001). Compared to the first hour of driving, drowsiness event rates rose significantly during the 13th to the 21st hours into the shift (13- 59 events/h vs 5.5 events/h, P= 0.0001 to 0.007). During sequential night shifts drowsiness events were 1.8 times more common compared to 1–3 sequential day shifts (9 events/h vs 5 events/h, P= 0.012 to 0.019). Conclusion Driving at night, for more than 12 hours and sequential night shifts increase real-time drowsiness in HVDs, with these factors interacting resulting in even higher rates of drowsiness events. Longitudinal studies in larger populations will further define how these factors interact to inform the work scheduling of HVDs to reduce the risk of drowsiness. Support This research was supported by the CRC for Alertness, Safety and Productivity.

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Chen, Xiyan, Xinlei Zheng, Chunjie Zhai, Chuqiao Chen, Konstantin A. Zimenko, Hongkui Wang, Haibing Yin, and Chenggang Yan. "Implicit Lyapunov Function-based Formation Control for Heterogeneous Vehicular Platoons with Time Delays." Journal of Physics: Conference Series 2419, no. 1 (January 1, 2023): 012059. http://dx.doi.org/10.1088/1742-6596/2419/1/012059.

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Abstract In order to lower the drivers’ driving pressure and improve traffic efficiency, academic and industrial interest in the cooperative adaptive cruise control (CACC) system has been substantial. In this research, we use the Implicit Lyapunov Function (ILF) technique to develop a switching controller for HVPs with temporal delays. The constant time headway strategy is utilized to construct the HVPs error model first. Then, the implicit Lyapunov function is used to develop the switching controller. Finally, the conditions of internal stability and string stability are obtained. The suggested switching controller has been shown to maintain internal and string stability in simulations involving heterogeneous vehicle platoons.

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Dall’Olio, Filippo G., Claudia Parisi, Laura Marcolin, Stefano Brocchi, Caroline Caramella, Nicole Conci, Giulia Carpani, et al. "Monitoring tumor growth rate to predict immune checkpoint inhibitors’ treatment outcome in advanced NSCLC." Therapeutic Advances in Medical Oncology 14 (January 2022): 175883592110583. http://dx.doi.org/10.1177/17588359211058391.

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Introduction: Radiological response assessment to immune checkpoint inhibitor is challenging due to atypical pattern of response and commonly used RECIST 1.1 criteria do not take into account the kinetics of tumor behavior. Our study aimed at evaluating the tumor growth rate (TGR) in addition to RECIST 1.1 criteria to assess the benefit of immune checkpoint inhibitors (ICIs). Methods: Tumor real volume was calculated with a dedicated computed tomography (CT) software that semi-automatically assess tumor volume. Target lesions were identified according to RECIST 1.1. For each patient, we had 3 measurement of tumor volume. CT-1 was performed 8–12 weeks before ICI start, the CT at baseline for ICI was CT0, while CT + 1 was the first assessment after ICI. We calculated the percentage increase in tumor volume before (TGR1) and after immunotherapy (TGR2). Finally, we compared TGR1 and TGR2. If no progressive disease (PD), the group was disease control (DC). If PD but TGR2 < TGR1, it was called LvPD and if TGR2 ⩾ TGR1, HvPD. Results: A total of 61 patients who received ICIs and 33 treated with chemotherapy (ChT) were included. In ICI group, 18 patients were HvPD, 22 LvPD, 21 DC. Median OS was 4.4 months (95% CI: 2.0–6.8, reference) for HvPD, 7.1 months (95% CI 5.4–8.8) for LvPD, p = 0.018, and 20.9 months (95% CI: 12.5–29.3) for DC, p < 0.001. In ChT group, 7 were categorized as HvPD, 17 as LvPD and 9 as DC. No difference in OS was observed in the ChT group (p = 0.786) Conclusion: In the presence of PD, a decrease in TGR may result in a clinical benefit in patients treated with ICI but not with chemotherapy. Monitoring TGR changes after ICIs administration can help physician in deciding to treat beyond PD.

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Snyder, Alison R., April L. Perotti, Kenneth C. Lam, and R. Curtis Bay. "The Influence of High-Voltage Electrical Stimulation on Edema Formation After Acute Injury: A Systematic Review." Journal of Sport Rehabilitation 19, no. 4 (November 2010): 436–51. http://dx.doi.org/10.1123/jsr.19.4.436.

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Context:Electrical stimulation is often used to control edema formation after acute injury. However, it is unknown whether its theoretical benefits translate to benefits in clinical practice.Objectives:To systematically review the basic-science literature regarding the effects of high-voltage pulsed stimulation (HVPS) for edema control.Evidence Acquisition:CINAHL (1982 to February 2010), PubMed (1966 to February 2010), Medline (1966 to February 2010), and SPORTDiscus (1980 to February 2010) databases were searched for relevant studies using the following keywords: edema, electrical stimulation, high-volt electrical stimulation, and combinations of these terms. Reference sections of relevant studies were hand-searched. Included studies investigated HVPS and its effect on acute edema formation and included outcome measures specific to edema. Eleven studies met the inclusion criteria. Methodological quality and level of evidence were assessed for each included study. Effect sizes were calculated for primary edema outcomes.Evidence Synthesis:Studies were critiqued by electrical stimulation treatment parameters: mode of stimulation, polarity, frequency, duration of treatment, voltage, intensity, number of treatments, and overall time of treatments. The available evidence indicates that HVPS administered using negative polarity, pulse frequency of 120 pulses/s, and intensity of 90% visual motor contraction may be effective at curbing edema formation. In addition, the evidence suggests that treatment should be administered in either four 30-min treatment sessions (30-min treatment, 30-min rest cycle for 4 h) or a single, continuous180-min session to achieve the edemasuppressing effects.Conclusions:These findings suggest that the basic-science literature provides a general list of treatment parameters that have been shown to successfully manage the formation of edema after acute injury in animal subjects. These treatment parameters may facilitate future research related to the effects of HVPS on edema formation in humans and guide practical clinical use.

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Zhang, Jian, Rui Guan, Fei Guo, Yu Zhou, Haozhang Sun, Junjiang Wang, and Yiyun Huang. "Study on the soft-start process of PSM high voltage power supply for ECRH." EPJ Web of Conferences 203 (2019): 04019. http://dx.doi.org/10.1051/epjconf/201920304019.

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The soft-start process of high voltage power supply (HVPS) based on pulse step modulation (PSM) for ECRH on EAST is introduced, which is the first procedure of system operation. The response process is detailed by proposing DC equivalent circuit model, process analysis and performance comparison is given under the conditions of different soft-start resistor parameters, and the theoretical analysis is proved by the simulation package ANSYS Simplorer simulations. The soft-start resistor is designed for the HVPS of 140GHz ECRH system for a smooth charging without overshoot of the capacitor[6], and the final experimental results show that it is in agreement with the theoretical analysis and is stable and reliable to the power devices.

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Luera, Micheal J., Brittany Dowling, Tyler W. D. Muddle, and Nathaniel D. M. Jenkins. "Differences in Rotational Kinetics and Kinematics for Professional Baseball Pitchers With Higher Versus Lower Pitch Velocities." Journal of Applied Biomechanics 36, no. 2 (April 1, 2020): 68–75. http://dx.doi.org/10.1123/jab.2019-0235.

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Pitch velocity (PV) is important for pitching success, and the pelvis and trunk likely influence pitch performance. The purposes of this study were to examine the differences in pelvis and trunk kinetics and kinematics in professional baseball pitchers who throw at lower versus higher velocities (HVPs) and to examine the relationships among pelvis and trunk kinetics and kinematics and PV during each phase of the pitch delivery. The pitch velocity, pelvis and trunk peak angular velocities, kinetic energies and torques, and elbow and shoulder loads were compared among HVPs (n = 71; PV ≥ 40.2 m/s) and lower velocities pitchers (n = 78; PV < 39.8 m/s), as were trunk and pelvis rotation, flexion, and obliquity among 7 phases of the pitching delivery. Relationships among the kinetic and kinematic variables and PVs were examined. Higher velocity pitchers achieved greater upper trunk rotation at hand separation (+7.2°, P < .001) and elbow extension (+5.81°, P = .002) and were able to generate greater upper trunk angular velocities (+36.6 m/s, P = .01) compared with lower velocity pitcher. Trunk angular velocity (r = .29) and upper trunk rotation at hand separation (r = .18) and foot contact (r = .17) were weakly related to PV. Therefore, HVPs rotate their upper trunk to a greater degree during the early phases of the pitching motion and subsequently generate greater trunk angular velocities and PV.

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Song, Yeong Geun, Jung Eun Hwang, Jiae An, Pyoung Beom Kim, Hyeong Bin Park, Hwan Joon Park, Seongjun Kim, et al. "The Growth and Physiological Characteristics of the Endangered CAM Plant, Nadopungnan (Sedirea japonica), under Drought and Climate Change Scenarios." Forests 13, no. 11 (November 2, 2022): 1823. http://dx.doi.org/10.3390/f13111823.

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No natural habitat of Sedirea japonica has been found in Korea for the past 20 years. This study was conducted to provide basic physiological data for the conservation strategy of this endangered plant in response to climate change. Soil fruit daylight system (SFDS) chambers were used and four treatment groups (2.6LVPD, 2.6HVPD, 8.5LVPD, and 8.5HVPD) were designed based on the RCP scenario (RCP 2.6, and 8.5) and VPD conditions (low VPD; LVPD, and high VPD; HVPD). Air dryness was induced in the HVPD groups during the daytime by increasing the atmospheric vapor pressure deficit (VPD). There was no significant difference based on the RCP scenario. However, the difference between LVPD and HVPD was considerable. Total CO2 uptake and transpiration were lower than those of LVPD due to the duration decrease of Phase I in 2.6HVPD and 8.5HVPD. There was a reduction in total biomass, leaf thickness, length, and the number of leaves. ABS/RC, DI0/RC, φD0, VK, VJ, and other chlorophyll fluorescence markers increased. φP0, RE0/RC, φE0, ψE0, φR0, RC/CS0, Sm, N, PIabs, DFabs, SFIabs, and PIabs,Total declined. Daily drought stresses impact the physiological mechanisms occurring at nighttime. The defense mechanisms against drought stress occur by conserving water by controlling the stomata, inactivating the reaction center, and increasing the dissipated energy through heat. In summary, S. japonica is flexible against drought stress.

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Boyle, Peter, Renwick James Hudspith, Taku Izubuchi, Andreas Jüttner, Christoph Lehner, Randy Lewis, Kim Maltman, Hiroshi Ohki, Antonin Portelli, and Matthew Spraggs. "|Vus| determination from inclusive strange tau decay and lattice HVP." EPJ Web of Conferences 175 (2018): 13011. http://dx.doi.org/10.1051/epjconf/201817513011.

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We propose and apply a novel approach to determining |Vus| which uses inclusive strange hadronic tau decay data and hadronic vacuum polarization functions (HVPs) computed on the lattice. The experimental and lattice data are related through dispersion relations which employ a class of weight functions having poles at space-like momentum. Implementing this approach using lattice data generated by the RBC/UKQCD collaboration, we show examples of weight functions which strongly suppress spectral integral contributions from the region where experimental data either have large uncertainties or do not exist while at the same time allowing accurate determinations of relevant lattice HVPs. Our result for |Vus| is in good agreement with determinations from K physics and 3-family CKM unitarity. The advantages of the new approach over the conventional sum rule analysis will be discussed.

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Chadni, Morad, Nadia Boussetta, Cédric Guerin, Fabien Lagalle, Aya Zoghlami, Patrick Perré, Florent Allais, Nabil Grimi, and Irina Ioannou. "Improvement of Sinapine Extraction from Mustard Seed Meal by Application of Emerging Technologies." Foods 12, no. 3 (January 23, 2023): 520. http://dx.doi.org/10.3390/foods12030520.

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Sinapine is a phenolic compound found in mustard (Brassica juncea) seed meal. It has numerous beneficial properties such as antitumor, neuroprotective, antioxidant, and hepatoprotective effects, making its extraction relevant. In this study, the extraction of sinapine was investigated using three methods: (i) from a mustard seed meal defatted by a supercritical CO2 (SC-CO2) pretreatment, (ii) by the implementation of high-voltage electrical discharges (HVEDs), (iii) and by the use of ultrasound. The use of SC-CO2 pretreatment resulted in a dual effect on the valorization of mustard seed meal, acting as a green solvent for oil recovery and increasing the yield of extracted sinapine by 24.4% compared to the control. The combination of ultrasound and SC-CO2 pretreatment further increased the yield of sinapine by 32%. The optimal conditions for ultrasound-assisted extraction, determined through a response surface methodology, are a temperature of 75 °C, 70% ethanol, and 100% ultrasound amplitude, resulting in a sinapine yield of 6.90 ± 0.03 mg/g dry matter. In contrast, the application of HVEDs in the extraction process was not optimized, as it led to the degradation of sinapine even at low-energy inputs.

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Hölzl, Roman, Lorenz Steckhan, Christian Lehsing, Steven W. Savage, and Alex R. Bowers. "Driving with Hemianopia VIII: Effects of a Vibro-Tactile Assistance System on Safety and Gaze Behavior in Pedestrian Crossing Situations." Safety 7, no. 1 (March 5, 2021): 18. http://dx.doi.org/10.3390/safety7010018.

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People with homonymous visual field defects (HVFDs), the loss of vision in the same half of the visual field in both eyes, are permitted to drive in some jurisdictions. However, the HVFD may cause difficulties in detecting hazards approaching on the side of the field loss (the blind side). An advanced driver assistance system (ADAS) could assist with hazard detection, but little research has been conducted to evaluate the potential benefits of an ADAS for visually impaired drivers. We developed a prototype vibro-tactile assistance system for drivers with HVFDs and conducted a proof-of-concept driving simulation study to evaluate the system. Given that pedestrian accidents are the second most frequent cause of death in road traffic and most of those accidents occur in urban scenarios, we evaluated the potential of the assistance system to improve responses to pedestrian hazards in a city environment. Sixteen participants, of which eight had HVFDs and eight had normal vision, took part. Our analyses evaluated the effects of the driver assistance system, crossing direction, and pedestrian behavior on the safety of pedestrian events and the participant’s gaze behavior at each of the 256 crossing situations. Generalized linear mixed effects models were used to assess binomial outcome variables. Despite the limited sample size, the results suggest that the vibro-tactile directional warnings were effective in directing the drivers’ gaze so that they were looking in the necessary direction before a potential hazard occurred. More time was spent fixating pedestrians on the blind side when the ADAS was engaged, and as a result, the safety of street crossings from the blind side improved. The effect of the ADAS was greater on responses to pedestrians from the blind than the seeing side. With an activated ADAS, crossings from the participants’ blind sides were as safe as crossings from their seeing sides, and it was as safe as the crossings when normally sighted participants were driving. The results suggest that the vibro-tactile ADAS is a promising approach to improve the safety of drivers with HVFD and surrounding traffic.

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Xiang, Jun, Ling He, Donglin Li, Shuliang Wei, and Zhong Wu. "Value of the systemic immune-inflammation index in predicting poor postoperative outcomes and the short-term prognosis of heart valve diseases: a retrospective cohort study." BMJ Open 12, no. 10 (October 2022): e064171. http://dx.doi.org/10.1136/bmjopen-2022-064171.

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ObjectiveSystemic immune-inflammation index (SII) is a novel biomarker that can predict poor outcomes in tumours, nervous system diseases and chronic heart failure. Here, we investigated the predictive value of SII on the poor postoperative outcomes and short-term prognosis of heart valve diseases (HVDs).Design, setting and participantsThis retrospective cohort study enrolled all consecutive patients with HVDs (aortic stenosis, aortic regurgitation, mitral stenosis and mitral regurgitation) who underwent surgery (valve replacement or valve repair) at the Affiliated Hospital of North Sichuan Medical College between 2017 and 2020.Main outcomes and measuresMajor complications in the perioperative period, all-cause mortality within 30 days and readmission within 30 days.ResultsA total of 431 patients with HVDs were enrolled in this study, including 202 males and 229 females, aged 58.9±27.3 years. SII levels of patients in the poor outcomes group were significantly higher than those of patients in the favourable outcomes group (658.40±436.29 vs 335.72±174.76, respectively; p<0.001). Multivariate logistic regression analysis showed that age (OR 1.064, 95% CI 1.026 to 1.104, p=0.025), SII (OR 1.034, 95% CI 1.012 to 1.631, p=0.008) and aortic cross-clamping time (OR 1.013, 95% CI 1.004 to 1.023, p=0.006) were independent risk factors for poor outcomes and short-term prognosis in patients with HVD. The area under the curve of poor outcomes predicted by SII in patients with HVD was 0.806 (95% CI 0.763 to 0.848) and the optimised cut-off value 423.8×109 /L, with a sensitivity of 70.3% and specificity of 81.1%. The incidence of poor outcomes (p<0.001), 30-day mortality (p<0.001) and 30-day readmission rate (p=0.026) in the high SII group was significantly higher than that in the low SII group.ConclusionsSII is closely related to poor postoperative outcomes and short-term prognosis of HVD and can serve as an independent predictive factor.

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Bitencourt Dias, Dayana, Marcela Lara Mendes, Vanessa Burgugi Banin, Pasqual Barretti, and Daniela Ponce. "Urgent-Start Peritoneal Dialysis: The First Year of Brazilian Experience." Blood Purification 44, no. 4 (2017): 283–87. http://dx.doi.org/10.1159/000478970.

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Background: This study aimed to evaluate mechanical and infectious complications associated with urgent-start peritoneal dialysis (PD) and patients and technique survival in the first 180 days. Methods: It was a prospective study that evaluated chronic patients who started unplanned PD using high-volume PD (HVPD) right after (<72 h) PD catheter placement. After hospital discharge, patients were treated with intermittent PD on alternate days in a dialysis unit until family training was provided. Results: Fifty-one patients fulfilling the following criteria were included: age was 62.1 ± 15 years, with diabetes as the main etiology of end-stage renal disease (39%), and uremia as the main dialysis indication (76%). Metabolic and fluid controls were achieved after 3 sessions of HVPD, and patients remained in intermittent PD for 23.2 ± 7.2 days. Mechanical complications occurred in 25.7% and peritonitis rate was 0.5 episode/patient-year. In the first 6 months, technique and patients survival rates were 86 and 82.4% respectively. Conclusion: The PD modality was a feasible and safe alternative to hemodialysis in the urgent-start dialysis.

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P. Shinde, Kirankumar, and S. R. Deore. "http://journalijcar.org/issues/atc-loss-reduction-electrical-distribution-system-implementation-hvds." International Journal of Current Advanced Research 6, no. 5 (May 28, 2017): 3842–47. http://dx.doi.org/10.24327/ijcar.2017.3847.0379.

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Korolev, Alexei, and George A. Isaac. "Shattering during Sampling by OAPs and HVPS. Part I: Snow Particles." Journal of Atmospheric and Oceanic Technology 22, no. 5 (May 1, 2005): 528–42. http://dx.doi.org/10.1175/jtech1720.1.

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Abstract The data on cloud particle sizes and concentrations collected with the help of aircraft imaging probes [optical array probes OAP-2DC, OAP-2DP, and the High Volume Precipitation Spectrometer (HVPS)] are widely used for cloud parameterization and validation of remote sensing. The goal of the present work is to study the effect of shattering of ice particles during sampling. The shattering of ice particles may occur due to 1) mechanical impact with the probe arms prior to their entering the sample volume, and 2) fragmentation due to interaction with turbulence and wind shear generated by the probe housing. The effect of shattering is characterized by the shattering efficiency that is equal to the ratio of counts of disintegrated particles, to all counts. The shattering efficiency depends on the habit, size, and density of ice particles, probe inlet design, and airspeed. For the case of aggregates, the shattering efficiency may reach 10% or even more. The shattering of ice particles results in an overcounting of small particles and an undercounting of large ones. The number of fragments in the images of shattered particles may reach several hundreds. It was found that particles as small as 600 μm may shatter after impact with the probe arms. The effect of particle shattering should be taken into account during data analysis and carefully considered in future designs of airborne cloud particle size spectrometers.

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Lebreton, Guillaume, Ciro Mastroianni, Julien Amour, and Pascal Leprince. "Implantation of Two HVADs Used as a Total Artificial Heart: A New Approach." Annals of Thoracic Surgery 107, no. 3 (March 2019): e165-e167. http://dx.doi.org/10.1016/j.athoracsur.2018.07.067.

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Song, Eunjung, Woojoo Lee, and Bo-Hyung Kim. "Model-Based Approach for Designing an Efficient Bioequivalence Study for Highly Variable Drugs." Pharmaceuticals 14, no. 11 (October 28, 2021): 1101. http://dx.doi.org/10.3390/ph14111101.

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The statistical procedures as outlined by the European Medicines Agency (EMA) and United States Food and Drug Administration (FDA) guidelines for bioequivalence testing of highly variable drugs (HVDs) are complex. Additionally, the sample size is affected by clinical study designs or practical real-world problems, such as dropout rate or study budget. To overcome these difficulties, we propose a model-based approach for the selection of a study design with a sample size that satisfies the bioequivalence criteria using simulation studies based on a pharmacokinetic (PK) model. The designed approach was implemented using a simulation procedure considering some conventionally measured factors, such as geometric mean ratio and within-subject coefficient of variation, with various PK information important in determining bioequivalence. All simulation results were assessed according to the EMA and FDA guidelines. Furthermore, power calculations from simulation results were interpreted with regard to PK characteristics and compared among 2 × 2, 3 × 3, and 2 × 4 crossover designs to determine the efficient design considering appropriate sample size and duration of the clinical study. The proposed approach can be applied to bioequivalence studies of all drugs. However, the current study was targeted at HVDs, which are highly likely to require detailed decision making for sample size and study design.

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Agback, Peter, Andrey Shernyukov, Francisco Dominguez, Tatiana Agback, and Elena I. Frolova. "Novel NMR Assignment Strategy Reveals Structural Heterogeneity in Solution of the nsP3 HVD Domain of Venezuelan Equine Encephalitis Virus." Molecules 25, no. 24 (December 10, 2020): 5824. http://dx.doi.org/10.3390/molecules25245824.

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In recent years, intrinsically disordered proteins (IDPs) and disordered domains have attracted great attention. Many of them contain linear motifs that mediate interactions with other factors during formation of multicomponent protein complexes. NMR spectrometry is a valuable tool for characterizing this type of interactions on both amino acid (aa) and atomic levels. Alphaviruses encode a nonstructural protein nsP3, which drives viral replication complex assembly. nsP3 proteins contain over 200-aa-long hypervariable domains (HVDs), which exhibits no homology between different alphavirus species, are predicted to be intrinsically disordered and appear to be critical for alphavirus adaptation to different cells. Previously, we have shown that nsP3 HVD of chikungunya virus (CHIKV) is completely disordered with low tendency to form secondary structures in free form. In this new study, we used novel NMR approaches to assign the spectra for the nsP3 HVD of Venezuelan equine encephalitis virus (VEEV). The HVDs of CHIKV and VEEV have no homology but are both involved in replication complex assembly and function. We have found that VEEV nsP3 HVD is also mostly disordered but contains a short stable α-helix in its C-terminal fragment, which mediates interaction with the members of cellular Fragile X syndrome protein family. Our NMR data also suggest that VEEV HVD has several regions with tendency to form secondary structures.

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Solanki, Arjun Singh, and Dolly Thankachan. "A Comparative Study for Effective Distribution Network System Among LVDS and HVDS." CSVTU Research Journal on Engineering and Technology 09, no. 01 (July 17, 2020): 16–22. http://dx.doi.org/10.30732/rjet.20200901003.

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Sävendahl, Lars, Tadej Battelino, Michael Højby Rasmussen, Meryl Brod, Paul Saenger, and Reiko Horikawa. "Effective GH Replacement With Once-weekly Somapacitan vs Daily GH in Children with GHD: 3-year Results From REAL 3." Journal of Clinical Endocrinology & Metabolism 107, no. 5 (December 29, 2021): 1357–67. http://dx.doi.org/10.1210/clinem/dgab928.

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Abstract Context Current GH therapy requires daily injections, which can be burdensome. Somapacitan is a long-acting GH derivative in development for treatment of GH deficiency (GHD). Objective Evaluate the efficacy, safety, and tolerability of once-weekly somapacitan after 3 years of treatment. Design A multicenter, randomized, controlled, phase 2 study comparing somapacitan and once-daily GH for 156 weeks (NCT02616562). Setting Twenty-nine sites in 11 countries. Patients Fifty-nine children with GHD randomized (1:1:1:1) and exposed to treatment. Fifty-three children completed the 3-year period. Interventions Patients received somapacitan (0.04 [n = 14], 0.08 [n = 15], or 0.16 [n = 14] mg/kg/wk) or daily GH (n = 14) (0.034 mg/kg/d, equivalent to 0.238 mg/kg/wk) subcutaneously during the first year, after which all patients on somapacitan received 0.16 mg/kg/wk. Main Outcome Measures Height velocity (HV) at year 3; changes from baseline in height SD score (HSDS), HVSDS, and IGF-I SDS. Results The estimated treatment difference (95% CI) in HV for somapacitan 0.16/0.16 mg/kg/wk vs daily GH at year 3 was 0.8 cm/y (−0.4 to 2.1). Change in HVSDS from baseline to year 3 was comparable between somapacitan 0.16/0.16 mg/kg/wk, the pooled somapacitan groups, and daily GH. A gradual increase in HSDS from baseline was observed for all groups. At year 3, mean HSDS was similar for the pooled somapacitan groups and daily GH. Change from baseline to year 3 in mean IGF-I SDS was similar across treatments. Conclusions Once-weekly somapacitan in children with GHD showed sustained efficacy over 3 years in all assessed height-based outcomes with similar safety and tolerability to daily GH. A plain language summary (1) is available for this study. Clinical trial information This study has been registered at ClinicalTrials.gov, number NCT02616562 (REAL 3).

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Wang, Wei, Shuwen Yang, Jingyu Yang, Qi Wang, and Minqiang Hu. "Optimization Analysis of Wireless Charging System for Monitoring Sensors Overhead the HVPLs Based on Impedance Matching." IEEE Transactions on Electromagnetic Compatibility 61, no. 4 (August 2019): 1207–16. http://dx.doi.org/10.1109/temc.2018.2855201.

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Wang, Mao, Wendong Ma, Yong Yang, Miaohui Li, Zege Wu, Huaichuan Hu, Jianqiang Feng, et al. "Development of lower hybrid wave power feedback control and experiments on EAST." Journal of Instrumentation 18, no. 01 (January 1, 2023): P01010. http://dx.doi.org/10.1088/1748-0221/18/01/p01010.

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Abstract A new method of power feedback control for the lower hybrid wave (LHW) systems on the experimental advanced superconducting tokamak (EAST) is presented. Different methods are applied to control the power of two LHW systems with different frequency at 2.45 GHz and at 4.6 GHz, respectively. The old method is applied to control the 4.6 GHz LHW power through the exciter of klystrons, and the new one is used to control the 2.45 GHz LHW power through the high voltage power supply (HVPS) system. The new method has been applied in EAST and successfully assisted the development of relevant experiments such as loop voltage control, q profile control.

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Mollica, Veronica, Stefano Brocchi, Filippo Gustavo Dall’Olio, Laura Marcolin, Alexandro Paccapelo, Matteo Santoni, Alessandro Rizzo, et al. "Tumor Growth Rate Decline despite Progressive Disease May Predict Improved Nivolumab Treatment Outcome in mRCC: When RECIST Is Not Enough." Cancers 13, no. 14 (July 12, 2021): 3492. http://dx.doi.org/10.3390/cancers13143492.

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Treatment response is usually assessed by the response evaluation criteria in solid tumors (RECIST). These criteria may not be adequate to evaluate the response to immunotherapy, considering the peculiar patterns of response reported with this therapy. With the advent of immunotherapy these criteria have been modified to include the evaluation of the peculiar responses seen with this type of therapy (iRECIST criteria), including pseudoprogressions and hyperprogressions. Tumor growth rate (TGR) is a dynamic evaluation that takes into account the kinetics of response to treatment and may help catch the real efficacy of an immunotherapy approach. We performed a retrospective monocentric study to explore the impact of TGR change after nivolumab administration as the second or later line of treatment in patients with metastatic renal cell carcinoma (RCC). We evaluated 27 patients, divided into three categories: Disease control (DC) if there was no PD; lower velocity PD (LvPD) if disease progressed but the TGR at second assessment (TGR2) was lower than the TGR at first assessment (TGR1); higher velocity PD (HvPD) if TGR2 was higher than TGR1. The median OS for the DC group was 11.0 months (95% CI 5.0–17.0) (reference) vs. (not reached) NR (95% CI NR-NR) for LvPD (HR 0.27; 95% CI 0.06–1.30; p 0.102) vs. NR (95% CI NR–NR) for HvPD (HR 0.23; 95% CI 0.06–0.88; p 0.032). There was no difference between LvPD and DC (HR 1.21; 95% CI 0.20–7.28; p 0.838). In patients with metastatic RCC, the second or later line of nivolumab treatment may lead to a deceleration in TGR resulting in an improved survival outcome similar to that observed in patients experiencing tumor regression. In this subgroup, especially in the presence of a clinical benefit, continuing the treatment beyond progression can be recommended.

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Bian, Decun, Jinchang Zhao, Shaoqing Niu, and Jinwen Wu. "Rock Fracturing under Pulsed Discharge Homenergic Water Shock Waves with Variable Characteristics and Combination Forms." Shock and Vibration 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/6236953.

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High voltage pulsed discharge in water (HVPD) is used throughout industry for fracturing both natural and man-made materials. Using HVPD, we modeled crack propagation of rocks under homenergic water shock waves (HWSW) with different characteristics and combination forms using a combination of experimental analysis and numerical simulation. The experimental results show that, under the same discharge energy (2 kJ), water shock waves (WSW) with different characteristics fractured the rock mass distinctly different. With a higher the peak pressure (PP) of WSW, more long cracks and microcracks were formed, creating a larger damage area. The numerical simulation results show that a single HWSWs impact with different characteristics will still only cause three long cracks to be well developed and almost no microcracks, when PP of HWSW was 3 MPa. With the increase of PP, the number of both long cracks and microcracks increased. This is consistent with the experimental results. When the peak pressure became greater than 15 MPa, crack propagation gradually became concentrated and the surrounding borehole wall became more severely broken. The rock model had optimal fracturing under the impact of the HWSW with a PP of 10 MPa. Also, the simulations showed that, under repeated-impacts of HWSWs with consistent characteristics, the fracturing characteristics were basically identical to those by a single-impact. While under the repeated-impact of HWSWs with variable characteristics, there was almost no relationship between the fracturing effect and the sequence of repeated-impacts. Finally, under a single-impact of HWSW with low PP and hydrostatic pressure (PH) acting within an initial crack (similar to hydraulic fracturing in a hydrocarbon well), the initial crack had excellent propagation with an increase in hydrostatic pressure. However, when PP of HWSW was too high, increasing PH had no effect on initial crack propagation.

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Yiyun, Huang. "Reconstruction of -35 kV/200 kW HVPS for Test of Klystron Units in LHCD System." Plasma Science and Technology 6, no. 2 (April 2004): 2224–27. http://dx.doi.org/10.1088/1009-0630/6/2/007.

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Claeys, M., I. Kourtchev, V. Pashynska, G. Vas, R. Vermeylen, W. Wang, J. Cafmeyer, et al. "Polar organic marker compounds in atmospheric aerosols during the LBA-SMOCC 2002 biomass burning experiment in Rondônia, Brazil: sources and source processes, time series, diel variations and size distributions." Atmospheric Chemistry and Physics 10, no. 19 (October 5, 2010): 9319–31. http://dx.doi.org/10.5194/acp-10-9319-2010.

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Abstract. Measurements of polar organic marker compounds were performed on aerosols that were collected at a pasture site in the Amazon basin (Rondônia, Brazil) using a high-volume dichotomous sampler (HVDS) and a Micro-Orifice Uniform Deposit Impactor (MOUDI) within the framework of the 2002 LBA-SMOCC (Large-Scale Biosphere Atmosphere Experiment in Amazônia – Smoke Aerosols, Clouds, Rainfall, and Climate: Aerosols From Biomass Burning Perturb Global and Regional Climate) campaign. The campaign spanned the late dry season (biomass burning), a transition period, and the onset of the wet season (clean conditions). In the present study a more detailed discussion is presented compared to previous reports on the behavior of selected polar marker compounds, including levoglucosan, malic acid, isoprene secondary organic aerosol (SOA) tracers and tracers for fungal spores. The tracer data are discussed taking into account new insights that recently became available into their stability and/or aerosol formation processes. During all three periods, levoglucosan was the most dominant identified organic species in the PM2.5 size fraction of the HVDS samples. In the dry period levoglucosan reached concentrations of up to 7.5 μg m−3 and exhibited diel variations with a nighttime prevalence. It was closely associated with the PM mass in the size-segregated samples and was mainly present in the fine mode, except during the wet period where it peaked in the coarse mode. Isoprene SOA tracers showed an average concentration of 250 ng m−3 during the dry period versus 157 ng m−3 during the transition period and 52 ng m−3 during the wet period. Malic acid and the 2-methyltetrols exhibited a different size distribution pattern, which is consistent with different aerosol formation processes (i.e., gas-to-particle partitioning in the case of malic acid and heterogeneous formation from gas-phase precursors in the case of the 2-methyltetrols). The 2-methyltetrols were mainly associated with the fine mode during all periods, while malic acid was prevalent in the fine mode only during the dry and transition periods, and dominant in the coarse mode during the wet period. The sum of the fungal spore tracers arabitol, mannitol, and erythritol in the PM2.5 fraction of the HVDS samples during the dry, transition, and wet periods was, on average, 54 ng m−3, 34 ng m−3, and 27 ng m−3, respectively, and revealed minor day/night variation. The mass size distributions of arabitol and mannitol during all periods showed similar patterns and an association with the coarse mode, consistent with their primary origin. The results show that even under the heavy smoke conditions of the dry period a natural background with contributions from bioaerosols and isoprene SOA can be revealed. The enhancement in isoprene SOA in the dry season is mainly attributed to an increased acidity of the aerosols, increased NOx concentrations and a decreased wet deposition.

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Anastasi, G. A., M. Buscemi, M. Aglietta, R. Caruso, A. Castellina, S. Costa, S. Gallian, et al. "Validation of high voltage power supplies for the 1-inch photomultipliers of AugerPrime, the Pierre Auger Observatory upgrade." Journal of Instrumentation 17, no. 04 (April 1, 2022): T04003. http://dx.doi.org/10.1088/1748-0221/17/04/t04003.

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Abstract In the framework of the upgrade of the Pierre Auger Observatory, a new high voltage module is being employed for the power supply of the 1-inch photomultiplier added to each water-Cherenkov detector of the surface array with the aim of increasing the dynamic range of the measurements. This module is located in a dedicated box near the electronics and comprises a low consumption DC-DC converter hosted inside an aluminum box. All the modules have undergone specific tests to verify their reliability in the extreme environmental conditions of the Argentinian pampa. In this paper, we describe the validation procedure and the facility developed to this aim. The successful results of the tests on the HVPS modules are presented and discussed.

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Bishop, Naomi, Alistair Horman, and Philip Woodman. "Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein–ubiquitin conjugates." Journal of Cell Biology 157, no. 1 (March 26, 2002): 91–102. http://dx.doi.org/10.1083/jcb.200112080.

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There is increasing evidence that ubiquitination of receptors provides an important endosomal sorting signal. Here we report that mammalian class E vacuolar protein-sorting (vps) proteins recognize ubiquitin. Both tumor susceptibility gene 101 (TSG101)/human VPS (hVPS)28 and hepatocyte growth factor receptor substrate (Hrs) cytosolic complexes bind ubiquitin-agarose. TSG101 and hVPS28 are localized to endosomes that contain internalized EGF receptor and label strongly for ubiquitinated proteins. Microinjection of anti-hVPS28 specifically retards EGF degradation and leads to endosomal accumulation of ubiquitin–protein conjugates. Likewise, depletion of TSG101 impairs EGF trafficking and causes dramatic relocalization of ubiquitin to endocytic compartments. Similar defects are found in cells overexpressing Hrs, further emphasizing the links between class E protein function, receptor trafficking, and endosomal ubiquitination.

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Jian, Zhang, Rui Junhui, Gao Zongqiu, Guo Fei, and Huang Yiyun. "Upgrade of the cathode HVPS system for 4.6 GHz LHCD on EAST using high speed PSM." Fusion Engineering and Design 171 (October 2021): 112539. http://dx.doi.org/10.1016/j.fusengdes.2021.112539.

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Claeys, M., I. Kourtchev, V. Pashynska, G. Vas, R. Vermeylen, W. Wang, J. Cafmeyer, et al. "Polar organic marker compounds in atmospheric aerosols during the LBA-SMOCC 2002 biomass burning experiment in Rondônia, Brazil: sources and source processes, time series, diel variations and size distributions." Atmospheric Chemistry and Physics Discussions 10, no. 4 (April 23, 2010): 10889–923. http://dx.doi.org/10.5194/acpd-10-10889-2010.

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Abstract. Measurements of polar organic marker compounds were performed on aerosols that were collected at a pasture site in the Amazon basin (Rondônia, Brazil) using a High-Volume dichotomous sampler (HVDS) and a Micro-Orifice Uniform Deposit Impactor (MOUDI). The samplings were conducted within the framework of the LBA-SMOCC (Large-Scale Biosphere Atmosphere Experiment in Amazônia – Smoke Aerosols, Clouds, Rainfall, and Climate: Aerosols From Biomass Burning Perturb Global and Regional Climate) campaign, which took place from 9 September till 14 November 2002, spanning the late dry season (biomass burning), the transition period, and the onset of the wet season (clean conditions). In the present study a more detailed discussion is presented compared to previous reports on the behavior of selected polar marker compounds, including: (a) levoglucosan, a tracer for biomass burning, (b) malic acid, a tracer for the oxidation of semivolatile carboxylic acids, (c) tracers for secondary organic aerosol (SOA) from isoprene, i.e., the 2-methyltetrols (2-methylthreitol and 2-methylerythritol) and the C5-alkene triols [2-methyl-1,3,4-trihydroxy-1-butene (cis and trans) and 3-methyl-2,3,4-trihydroxy-1-butene], and (d) sugar alcohols (arabitol, mannitol, and erythritol), tracers for fungal spores. The results obtained for levoglucosan are covered first with the aim to address its contrasting behavior with that of malic acid, the isoprene SOA tracers, and the fungal spore tracers. The tracer data are discussed taking into account new insights that recently became available into their stability and/or aerosol formation processes. During all three periods, levoglucosan was the most dominant identified organic species in the PM2.5 size fraction of the HVDS samples. In the dry period levoglucosan reached concentrations of up to 7.5 μg m−3 and exhibited diel variations with a nighttime prevalence. It was closely associated with the PM mass in the size-segregated samples and was mainly present in the fine mode, except during the wet period where it peaked in the coarse mode. Isoprene SOA tracers showed an average concentration of 250 ng m−3 during the dry period versus 157 ng m−3 during the transition period and 52 ng m−3 during the wet period. Malic acid and the 2-methyltetrols exhibited a different size distribution pattern: while the 2-methyltetrols were mainly associated with the fine mode during all periods, malic acid was prevalent in the fine mode only during the dry and transition periods, while it was dominant in the coarse mode during the wet period, consistent with different formation processes. The sum of arabitol, mannitol, and erythritol in the PM2.5 fraction of the HVDS samples during the dry, transition, and wet periods was, on average, 54 ng m−3, 34 ng m−3, and 27 ng m−3, respectively, and revealed minor day/night variation. The mass size distributions of arabitol and mannitol during all periods showed similar patterns and an association with the coarse mode, consistent with their primary origin. The results show that even under the heavy smoke conditions of the dry period a natural background with contributions from bioaerosols and isoprene SOA can be revealed. The enhancement in isoprene SOA in the dry season is mainly attributed to an increased acidity of the aerosols and a decreased wet deposition.

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Babu, P. Ravi, B. Sushma, and Ashwin Kumar B. "HVDS approach for reducing the Technical and Non-technical losses to enhance the Electrical Distribution System performance." i-manager's Journal on Electrical Engineering 6, no. 1 (September 15, 2012): 37–41. http://dx.doi.org/10.26634/jee.6.1.1953.

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43

Wang, Weitian, Jianye Wang, Liang Wang, Peng Xu, and Yong Song. "Spectrum Analyses and Diagnoses of 350 kV HVPS Ripples on High Intensity D–T Fusion Neutron Generator." Journal of Fusion Energy 34, no. 5 (March 25, 2015): 989–94. http://dx.doi.org/10.1007/s10894-015-9909-4.

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44

Petinaux, MD, Bruno, Brandy Ferguson, MD, Milena Walker, MD, CIC, Yeo-Jin Lee, RN, MPH, CIC, Gary Little, MD, David Parenti, MD, and Gary Simon, MD, PhD. "A proposed emergency management program for acute care facilities in response to a highly virulent infectious disease." Journal of Emergency Management 14, no. 1 (January 1, 2016): 17. http://dx.doi.org/10.5055/jem.2016.0269.

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To address the organizational complexities associated with a highly virulent infectious disease (HVID) hazard, such as Ebola Virus Disease (EVD), an acute care facility should institute an emergency management program rooted in the fundamentals of mitigation, preparedness, response, and recovery. This program must address all known facets of the care of a patient with HVID, from unannounced arrival to discharge. The implementation of such a program not only serves to mitigate the risks from an unrecognized exposure but also serves to prepare the organization and its staff to provide for a safe response, and ensure a full recovery. Much of this program is based on education, training, and infection control measures along with resourcing for appropriate personal protective equipment which is instrumental in ensuring an organized and safe response of the acute care facility in the service to the community. This emergency management program approach can serve as a model in the care of not only current HVIDs such as EVD but also future presentations in our healthcare setting.

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45

Kang, Chun-Ho, Sung-Wook Lee, Hong-Hak Lee, Chang-Hoon Lee, and Gi-Sig Byun. "Hardware configuration of High-Density HVPS and High Speed independent Control method Using FPGA for Phased Array Transmitters." Journal of the Korea Institute of Information and Communication Engineering 19, no. 11 (November 30, 2015): 2758–64. http://dx.doi.org/10.6109/jkiice.2015.19.11.2758.

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46

Galtseva, Olga, Sergey Bordunov, Alexandr Zhiganov, Inna Plotnikova, and Jian Min Li. "Technology of Gold-Containing Technogenic Raw Materials Processing Using the Electric Explosion Method." Materials Science Forum 942 (January 2019): 30–39. http://dx.doi.org/10.4028/www.scientific.net/msf.942.30.

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The paper shows fundamental possibility of processing of gold-bearing technogenic raw materials using the method of electric explosion. A series of experiments using a laboratory and pilot-production high-voltage pulsed discharge (HVPD) installation for the processes of enrichment of gold-bearing mineral raw materials of Komsomolsk mine tailings in Kemerovo region is conducted with a relatively low energy electrical discharge in the pulse of up to 112.5 Joules and the cost of electric power of about 1.5 kW/ton of raw material, that allows complete destruction of clay components agglomerations to less than 0.045 mm (micron and submicron sizes). Solid minerals such as quartz are simultaneously destroyed by defects in the grains and withdrawn from the installation with water, thus increasing gold degree of the concentrate. The results of particle-size and X-ray structural analyses of gold-bearing mineral raw materials of Komsomolsk mine tailings in Kemerovo region obtained by the method of electric explosion are discussed.

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47

Carannante, Giuseppe, Mario Cavinato, Katarina Cindric, Peter De Vries, Federico Felici, Martino Giordano Ferrari, Giuseppe Ferrò, et al. "ITER ECH&CD Control System: Architecture, interfaces and status of development." EPJ Web of Conferences 277 (2023): 04002. http://dx.doi.org/10.1051/epjconf/202327704002.

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The ITER ECH&CD system is designed to inject 20 MW of millimetre-wave at 170 GHz into the vacuum vessel. The system is composed of many sub-systems, namely High-Voltage Power Supplies (HVPS), Gyrotrons, Transmission Lines (TL), Ex-vessel Waveguides (EW), Launchers. It is the role of the EC Plant Controller (ECPC) to integrate all the Sub-system Control Units (SCU), to prepare the system for operation and to execute the real-time requests coming from the plasma control system. The ECPC also implements plant level protection functions involving more than one sub-system and it interfaces with the ITER Central I&C. This paper gives an overview of the EC system and a description of the control system development focusing on the architecture and the interfaces. Control and protection functions are presented together with a functional allocation to better define interfaces and responsibilities. The preliminary design of the interface with the Plasma Control System to implement advanced control functions is also presented.

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48

Miranda, Felipe de Souza, Eduardo Sant'Ana Petraconi Prado, Cristian Cley Paterniani Rita, Roberson José da Silva, Mauricio Ribeiro Baldan, and Gilberto Petraconi Filho. "Deposição de recobrimentos de proteção térmica e ambiental por plasma spray utilizando precursor híbrido de SiO2+ZrO2/ Plasma spray deposition of thermal and environmental protection coatings using SiO2+ZrO2 hybrid precursor." Brazilian Applied Science Review 5, no. 4 (July 6, 2021): 1755–66. http://dx.doi.org/10.34115/basrv5n4-002.

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Compósitos reforçados com fibra de carbono (C/C) são materiais amplamente utilizados em componentes estruturais, especialmente quando expostos as intensas cargas aerotermodinâmicas. Sua alta resistência e excepcional tenacidade à fratura, combinados com suas propriedades refratárias, resistência à erosão, corrosão e desgaste tornam este material ideal para aplicações em componentes estruturais, submetidos a altas temperaturas, tais como turbinas e veículos de reentrada atmosférica. Quando utilizados em atmosferas inertes ou em vácuo, os compósitos C/C mantêm suas propriedades a temperaturas superiores a 2000°C. Porém, nas condições de ambientes oxidantes e de elevadas temperaturas, os compósitos a base de fibras de carbono sofrem intensa degradação devido à elevada catalicidade de reações entre o carbono e o oxigênio, dificultando e, muitas vezes, impossibilitando seu uso em dispositivos aeroespaciais. Neste contexto, o objetivo deste trabalho é a deposição de recobrimentos de barreira ambiental (Environmental Barrier Coating, EBC), utilizando precursores híbridos de ZrO2+SiO2 visando proteção contra oxidação dos compósitos estruturais de C/C. Os recobrimentos serão depositados por meio do processo de spray a plasma de alta velocidade (High Velocity Plasma Spray, HVPS).

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49

Alhamlan, Fatimah Saeed, Ahmed A. Al-Qahtani, and Mohammed N. Al-Ahdal. "Current studies on human papillomavirus in Saudi Arabia." Journal of Infection in Developing Countries 9, no. 06 (July 4, 2015): 571–76. http://dx.doi.org/10.3855/jidc.6538.

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Human papillomavirus (HPV) infection is a significant etiological factor and an important prognosticator in cervical cancer. Indeed, researchers worldwide have confirmed these roles for high-risk HVPs in over 70% of cervical cancer cases. According to the World Health Organization, approximately 561,200 new cancer cases (5.2% of all new cancers) are attributed to HPV infection. Over 120 types of HPV are classified further as either low-risk HPV (LR-HPV) or high-risk HPV (HR-HPV) based on their oncological potential of transforming cells. The LR-HPV types cause benign hyperproliferative lesions (i.e. genital warts) while the HR-HPV types are strongly associated with premalignant and malignant cervical lesions. Data on the prevalence of HPV, survival of infected patients, and mortality rate are scarce in Saudi Arabia. The unsubstantiated assumption of a low prevalence of HPV in Saudi Arabia has contributed to limiting HPV research in this conservative country. Therefore, the goal of this review is to shed light on the current HPV research being conducted and the prevalence of HPV in Saudi Arabia.

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Wang, Xiaodong, Jiaxu Du, and Ningjing Li. "Research on Crushing Concrete Members by High-Voltage Pulse Discharge Technology." Advances in Civil Engineering 2021 (May 22, 2021): 1–14. http://dx.doi.org/10.1155/2021/5511959.

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High-voltage pulse discharge (HVPD) is an energy-saving, efficient, and green technique, which has broad prospects in concrete crushing. The finite element models of the concrete beam, slab, and column segments were established with ANSYS/LS-DYNA finite element software. Based on the principle of equal impact pressure, the shock wave generated by the fuse explosion caused by HVPD of 50 kJ is equivalent to the impact load of explosive blasting, and the stress of concrete beam segment was analyzed. The finite element models of the concrete beam sections were established to investigate the influence of diameter and spacing of the holes on the crushing effect of concrete beam segments. The width × height of each beam segment is 400 mm × 800 mm, and there are six types of beam segment length: 600 mm, 700 mm, 800 mm, 900 mm, 1000 mm, and 1100 mm. Two holes are drilled vertically on the surface of the width × length of each beam segment. The spacing of holes corresponding to beam segments of each length type is 200 mm, 300 mm, 400 mm, 500 mm, 600 mm, and 700 mm, respectively. The hole depth of each beam segment is 650 mm, and there are three types of aperture: 30 mm, 50 mm, and 70 mm. The analysis results show that the crushing effect of concrete beam segments increases with the increase of aperture and the decrease of hole spacing. According to the crushing effect of the beam segments, the aperture of 50 mm, the spacing of 400 mm, and the hole end (edge) spacing of 250 mm were determined as the optimal hole layout scheme. The finite element models of concrete slabs and columns were established. The square concrete slab thickness is 140 mm and side length is 700 mm, 800 mm, and 900 mm, respectively. Double-row holes were arranged in the slabs and the aperture is 50 mm and the hole spacing is 200 mm, 300 mm, and 400 mm, respectively. The section sizes of concrete columns are 500 mm × 500 mm, 600 mm × 600 mm, and 700 mm × 700 mm, respectively, and the aperture is 50 mm and the hole distance is 400 mm. According to the results of analysis, the optimal hole distribution scheme of concrete slab and column is chosen as the aperture of 50 mm and hole distance of 400 mm. The principle of the layout of multirow holes is that the spacing of row is not more than 400 mm, and the margin is not more than 250 mm.

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