Дисертації з теми "Human Simulations"
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Mufti, H. (Haseeb). "Human body communication performance simulations." Master's thesis, University of Oulu, 2016. http://urn.fi/URN:NBN:fi:oulu-201606092482.
Повний текст джерелаEngmo, Vidar. "Representation of Human Behavior in Military Simulations." Thesis, Norwegian University of Science and Technology, Department of Telematics, 2008. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-9798.
Повний текст джерелаThe purpose of this master thesis was to investigate the psychological and computational basis for human behavior representation (HBR) in military simulations and identify problem areas of existent software agent frameworks that provide computer generated forces (CGF) with human like cognitive abilities. The master thesis identifies psychological properties that influence human cognition in an operational environment through a theoretical study of operational and cognitive psychology. The psychological properties of human cognition are then connected to artificial intelligence through a theoretical study of agents and multi-agent systems and form the foundation for identifying general HBR properties. The HBR properties are used as evaluation markers that constitute the basis for constructing an evaluation of relevant agent frameworks thereby visualizing their strengths and weaknesses. The problem areas of incorporating artificial intelligence into CGF are further concretized by the development of a demonstrator that interacts with a synthetic environment. The demonstrator is an implementation of a tank platoon in the agent framework Jadex. The synthetic environment is provided by VR-Forces which is a product by MÄK technologies. The thesis makes a distinction between the conceptual structure of agent frameworks and their actual implementation. According to this master thesis it is the output of the agent framework that is the most important feature not how the output came into being. Producing the correct output requires the selection of the correct tools for the job. The selection of an agent framework should be taken on the background of an evaluation of the simulation requirements. A large portion of the development time is consumed by the development of application and communication interfaces. The problem is a result of lacking standardization and that most cognitive agent frameworks are experimental in nature. In addition the artificial intelligence (AI) in such simulations is often dived into levels, where the synthetic environment takes care of low-level AI and the agent framework the high-level AI. Tight synchronization between low and high-level AI is important if one wishes to create sensible behavior. The purpose of an agent framework in conjunction with CGF is thereby ensuring rapid development and testing of behavior models.
Starling, James Kendall. "Prioritizing unaided human search in military simulations." Thesis, Monterey, California. Naval Postgraduate School, 2011. http://hdl.handle.net/10945/5622.
Повний текст джерелаSearch and Target Acquisition (STA) in military simulations is the process of first identifying targets in a particular setting, then determining the probability of detection. This study will focus on the search aspect in STA, particularly with unaided vision. Current algorithms in combat models use an antiquated windshield wiper search pattern when conducting search. The studies used to determine these patterns used aided vision, such as binoculars or night vision devices. Very little research has been conducted for unaided vision and particularly not in urban environments. This study will use a data set taken from an earlier study in Fort Benning, GA, which captured the fixation points of 27 participants in simulated urban environments. This study achieved strong results showing that search is driven by salient scene information and is not random, using a series of nonparametric tests. The proposed algorithm, using points of interest (POIs) for the salient scene information, showed promising results for predicting the initial direction of search from the empirical data. However, the best results were realized when breaking the field of regard (FOR) into a small number of fields of view (FOVs).
Singh, Meghendra. "Human Behavior Modeling and Calibration in Epidemic Simulations." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/87050.
Повний текст джерелаMaster of Science
In the real world, individuals can decide to adopt certain behaviors that reduce their chances of contracting a disease. For example, using hand sanitizers can reduce an individual‘s chances of getting infected by influenza. These behavioral decisions, when taken by many individuals in the population, can completely change the course of the disease. Such behavioral decision-making is generally not considered during in-silico simulations of infectious diseases. In this thesis, we address this problem by developing a methodology to create and calibrate a decision making model that can be used by agents (i.e., synthetic representations of humans in simulations) in a data driven way. Our method also finds a cost associated with such behaviors and matches the distribution of behavior observed in the real world with that observed in a survey. Our approach is a data-driven way of incorporating decision making for agents in large-scale epidemic simulations.
Kaphle, Manindra. "Simulations of human movements through temporal discretization and optimization." Licentiate thesis, KTH, Mechanics, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4585.
Повний текст джерелаStudy of physical phenomena by means of mathematical models is common in various branches of engineering and science. In biomechanics, modelling often involves studying human motion by treating the body as a mechanical system made of interconnected rigid links. Robotics deals with similar cases as robots are often designed to imitate human behavior. Modelling human movements is a complicated task and, therefore, requires several simplifications and assumptions. Available computational resources often dictate the nature and the complexity of the models. In spite of all these factors, several meaningful results are still obtained from the simulations.
One common problem form encountered in real life is the movement between known initial and final states in a pre-specified time. This presents a problem of dynamic redundancy as several different trajectories are possible to achieve the target state. Movements are mathematically described by differential equations. So modelling a movement involves solving these differential equations, along with optimization to find a cost effective trajectory and forces or moments required for this purpose.
In this study, an algorithm developed in Matlab is used to study dynamics of several common human movements. The main underlying idea is based upon temporal finite element discretization, together with optimization. The algorithm can deal with mechanical formulations of varying degrees of complexity and allows precise definitions of initial and target states and constraints. Optimization is carried out using different cost functions related to both kinematic and kinetic variables.
Simulations show that generally different optimization criteria give different results. To arrive on a definite conclusion on which criterion is superior over others it is necessary to include more detailed features in the models and incorporate more advanced anatomical and physiological knowledge. Nevertheless, the algorithm and the simplified models present a platform that can be built upon to study more complex and reliable models.
Kaphle, Manindra. "Simulations of human movements trough temporal descretization and optimization /." Stockholm : Department of Mechanics, Royal Institute of Technology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4585.
Повний текст джерелаHe, Xiaoyi. "Numerical simulations of blood flow in human coronary arteries." Diss., Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/16685.
Повний текст джерелаCrawford, Kenneth. "Effect of Safety Factors on Timed Human Egress Simulations." University of Canterbury. Civil Engineering, 1999. http://hdl.handle.net/10092/8261.
Повний текст джерелаJungkunz, Patrick. "Modeling human visual perception for target detection in military simulations." Monterey, Calif. : Naval Postgraduate School, 2009. http://handle.dtic.mil/100.2/ADA501666.
Повний текст джерелаDissertation Advisor(s): Darken, Christian J. "June 2009." Description based on title screen as viewed on July 10, 2009. DTIC Identifiers: Human visual perception, visual attention, eye tracking, human behavior modeling, visual search, semantic relevance, relevance mapa. Author(s) subject terms: Human Visual Perception, Visual Attention, Eye Movements, Eye Tracking, Human Behavior Modeling, Target Detection, Visual Search, Semantic Relevance, Relevance Map. Includes bibliographical references (p. 145-149). Also available in print.
Rivas, Romero Daniela Paz. "Molecular Dynamics Simulations of Human Glucose Transporters and Glutamate Transporters." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25113.
Повний текст джерелаUricchio, Lawrence Hart. "Models and forward simulations of selection, human demography, and complex traits." Thesis, University of California, San Francisco, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3681226.
Повний текст джерелаEvolutionary forces such as recombination, demography, and selection can shape patterns of genetic diversity within populations and contribute to phenotypic variation. While theoretical models exist for each of these forces independently, mathematically modeling their joint impact on patterns of genetic diversity remains very challenging. Fortunately, it is possible to perform forward-in-time computer simulations of DNA sequences that incorporate all of these forces simultaneously. Here, I show that there are trade-offs between computational efficiency and accuracy for simulations of a widely investigated model of recurrent positive selection. I develop a theoretical model to explain this trade-off, and a simple algorithm that obtains the best possible computational performance for a given error tolerance. I then pivot to develop a framework for simulations of human DNA sequences and genetically complex phenotypes, incorporating recently inferred demographic models of human continental groups and selection on genes and non-coding elements. I use these simulations to investigate the power of rare variant association tests in the context of rampant selection and non-equilibrium demography. I show that the power of rare variant association tests is in some cases quite sensitive to underlying assumptions about the relationship between selection and effect sizes. This work highlights both the challenge and the promise of applying forward simulations in genetic studies that seek to infer the parameters of evolutionary models and detect statistical associations.
Yassin, Nihad Jaro. "Application of parametric and solid modelling techniques to human body simulations." Thesis, Heriot-Watt University, 1992. http://hdl.handle.net/10399/1384.
Повний текст джерелаBoucher, Luke. "Learning the structure of artificial grammars : computer simulations and human experiments." Thesis, University of Sussex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298103.
Повний текст джерелаFears, Tellis A. "Framing cultural attributes for human representation in military training and simulations." Thesis, Monterey, Calif. : Naval Postgraduate School, 2008. http://edocs.nps.edu/npspubs/scholarly/theses/2008/Sept/08Sep%5FFears.pdf.
Повний текст джерелаThesis Advisor(s): Gibbons, Deborah ; Blais, Curtis. "September 2008." Description based on title screen as viewed on November 4, 2008. Includes bibliographical references (p. 39-42). Also available in print.
Zordan, Victor B. "Motion capture-driven simulations that hit and react." Diss., Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/8314.
Повний текст джерелаDawson, Karen Margaret. "Advanced thermal hydraulic simulations for human reliability assessment of nuclear power plants." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/112392.
Повний текст джерелаThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 101-102).
Human Risk Assessment (HRA) in the nuclear power industry has advanced in the last two decades. However, there is a lack of understanding of the magnitude of the effect of thermal hydraulic (TH) uncertainties upon the failure probabilities of the operator actions of nuclear units. I demonstrate in this work that there is an effect of TH uncertainties on the operating crew's probability of recognizing errors during a loss of coolant accident (LOCA) initiating event. The magnitude of the effect of the TH uncertainty on the operator's ability to recognize errors is dependent upon the size of the break, the operating state of the plant (in operation or shutting down), and the error that is committed. I utilized an uncertainty software, Dakota, coupled with an advanced TH software, MAAP4, to perform a Monte Carlo analysis to propagate selected TH uncertainties through a LOCA initiating event in which the automatic safety coolant injection system fails to automatically actuate. The operator mission is to manually actuate the safety coolant injection system. Two errors that the operating crew could make are 1) entering fire procedures and 2) testing for saturation of the primary system before the saturation occurs. I calculate the operator failure probabilities using the MERMOS HRA methodology (used by the French electric utility company Electricité de France, EdF). My results show a reduction in scenario failure probability from the values reported by EdF in its published MERMOS Catalogue of more than 80% for the operator recognizing the the error in entering fire procedures. For the error in testing for saturation of the primary system before saturation occurs, I calculated a scenario failure probability in Mode B of 0.0033, while the MERMOS Catalogue listed the scenario failure probability as negligible. My results show that there is an effect from TH uncertainties on operator failure probabilities. This research provides a method of improving the accuracy of failure probabilities in established HRA methodologies using TH simulations.
by Karen Margaret Dawson.
S.M.
Martínez, Mateu Laura. "Mapping of the electrical activity of human atria. Multiscale modelling and simulations." Doctoral thesis, Universitat Politècnica de València, 2018. http://hdl.handle.net/10251/104604.
Повний текст джерелаAtrial fibrillation is one of the most common cardiac arrhythmias seen in clinical practice. Therefore, it is of vital importance to develop new technologies aimed at diagnosing and terminating this kind of arrhythmia, to improve the quality of life of patients and to reduce costs to national health systems. In the last years, new atrial mapping techniques based on multi-electrode systems are increasingly being used to map the atrial electrical activity in humans and localise and target atrial fibrillation drivers in the form of focal sources or rotors. However, significant concerns remain about their accuracy and experimental approaches to analyse them are limited due to their invasive character. Therefore, computer simulations are a helpful tool to overcome these limitations since they can reproduce with fidelity experimental observations, permit to split the problem to treat into more simple substudies, and allow the possibility of performing preliminary investigations impossible to carry out in the clinical practice. This PhD thesis is focused on the analysis for accuracy of the multielectrode mapping systems through computational models and simulations. For this purpose, we developed realistic multiscale models in order to simulate atrial electrical reentrant activity, first in a sheet of atrial tissue and, then, in the whole atria. Then, we analysed the effects of the multi-electrode geometrical configurations on the accuracy of localizing rotors, by using multi-electrode arrays with equidistant inter-electrode distances, as well as multi-electrode basket catheters with non-equidistant inter-electrode distances. After computing the intracavitary unipolar electrograms, we performed phase maps, phase singularity detections to track rotors, and dominant frequency maps. We finally found out that the accuracy of multi-electrode mapping systems depends on their position inside the atrial cavity, the electrode-to-tissue distance, the inter-electrode distance, and the contribution of far field sources. Furthermore, as a consequence of these factors, false rotors might appear and could contribute to failure of atrial fibrillation ablation procedures.
La fibril·lació auricular és una de les arítmies cardíaques més comuns observades en la pràctica clínica. Per tant, és de vital importància desenvolupar noves tecnologies destinades a diagnosticar i acabar amb aquest tipus d'arítmia, per tal de millorar la qualitat de vida dels pacients i reduir els costos dels sistemes nacionals de salut. En els últims anys, ha augmentat l'ús de les noves tècniques de mapeig auricular, basades en sistemes multielèctrode per a mapejar l'activitat elèctrica auricular en humans. Aquestes tècniques permeten localitzar i ablacionar els impulsors de la fibril·lació auricular, com són les fonts focals o els rotors. No obstant això, encara hi ha incertesa sobre la seua precisió i els procediments experimentals per al seu anàlisi estan limitats a causa del seu caràcter invasiu. Per tant, les simulacions computacionals són una eina molt útil per a superar aquestes limitacions, en permetre reproduir amb fidelitat les observacions experimentals, dividir el problema sota estudi en subestudis més simples, i realitzar investigacions preliminars impossibles de dur a terme en el pràctica clínica. Aquesta tesi doctoral es centra en l'anàlisi de la precisió del sistemes de mapeig multielèctrode mitjançant els models i les simulacions computacionals. Per a això, desenvolupàrem models realistes multiescala per tal de simular activitat elèctrica auricular reentrant, en primer lloc en una làmina de teixit auricular, i en segon lloc a les aurícules completes. Posteriorment, analitzàrem els efectes de les configuracions geomètriques multielèctrode en la precisió de la localització dels rotors, mitjançant l'ús d'agrupacions multielèctrode amb distàncies interelèctrode equidistants, així com catèters de tipus basket amb distàncies interelèctrode no equidistants. Després de calcular els electrogrames unipolars intracavitaris, vam realitzar mapes de fase, deteccions de singularitat de fase per a rastrejar els rotors, i mapes de freqüència dominants. Finalment, vam descobrir que la precisió dels sistemes de mapeig multielèctrode depèn de la seua posició dins de la cavitat auricular, de la distància entre els elèctrodes i el teixit, de la distància interelèctrode, i de la contribució de les fonts de camp llunyà. A més, com a conseqüència d'aquests factors, es va observar l'aparició de rotors falsos que podrien contribuir al fracàs de l'ablació de la fibril·lació auricular.
Martínez Mateu, L. (2018). Mapping of the electrical activity of human atria. Multiscale modelling and simulations [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/104604
TESIS
Fabbri, Alan <1985>. "Computational modeling of human sinoatrial node: what simulations tell us about pacemaking." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amsdottorato.unibo.it/8674/1/fabbri_alan_phD_thesis_final.pdf.
Повний текст джерелаLyu, Yeonhwan. "Simulations and Second / Foreign Language Learning: Improving communication skills through simulations." See Full Text at OhioLINK ETD Center (Requires Adobe Acrobat Reader for viewing), 2006. http://www.ohiolink.edu/etd/view.cgi?toledo1147363791.
Повний текст джерелаGIORDANO, DEBORAH. "Transglutaminase, nutrition and human health." Doctoral thesis, Università degli Studi di Foggia, 2019. http://hdl.handle.net/11369/382619.
Повний текст джерелаBackground: transglutaminases (TGase) are a class of enzymes widely spread in eukaryotic and prokaryotic organisms. Enzymes of this family catalyze post-translational modifications in many proteins by acyl transfer reactions, deamidation and crosslinking (polymerisation) between protein intra- or inter-chain glutamine (acyl donor) and lysine (acyl acceptor) peptide residues. Due to its facility of expression and purification, the only TGase enzyme widely used for industrial applications is the microbial TGase extracted from Streptomyces mobaraensis (MTGase). Nowadays the MTGase is commercially available and widely used in biopolymers industry, in cosmetics, in clinical applications, in wool textiles, and above all in the food processing industry. Its ability to catalyze crosslinks on many different protein substrates is increasingly used not only for sausage, ham and cheese production but, very recently, also for flour detoxification, as a possible alternative therapy to the gluten free diet. It follows that nowadays the industrial applications of MTGase have increased, covering more and more fields producing a very active scientific research about this topic aimed at attempt to meet specific industrial needs, as the implementation of more efficient system for MTGase production, the research of alternative sources of microbial TGase, and safe source of recombinant enzymes. Aims of the doctorate project: the main aim of the project is the identification of novel forms of microbial TGases that could become an alternative to that in use. A depth screening of known sequences has been performed, with the aim of obtaining a classification of microbial TGases for their similarity to known forms. To select the best candidates to be active forms under appropriate conditions, molecular modelling and molecular simulations have been performed on selected sequences. To test the enzymatic activity, experimental assays have been performed with a novel form, and another novel form has been expressed. Results: the present work proposes at first an analysis, lacking so far, of the wide microbial transglutaminase world, developing the first classification of the microbial TGase based on their sequence features and their specific predicted secondary structures. In order to classify and analyze the structural features of all the sequences annotated as having a TGase core computational techniques involving sequence analyses, comparative studies, building of phylogenetic trees, homology models and molecular dynamic simulations have been used. From this approach, a preliminary classification of these sequences was done by dividing them in five main groups. Each group has been investigated from the sequence point of view to analyze the presence of specific motifs. For three of this five groups, also the secondary structures have been investigated and, from this analysis, features specific for each group have been detected. Moreover, two novel forms of microbial TGase (mTGase) have been investigated in the detail: K. albida mTGase and the hypothetical mTGase from SaNDy (organism not disclosed for patent opportunity). Molecular dynamics simulations and active site pocket analyses have been performed for the first, in comparison with MTGase. For the second, instead, experimental technique has been used to purify the hypothetical enzyme in order to test it on food related substrates. Experimental assays on both the proteins are still ongoing, to find the best enzymatic activity conditions and the best substrates of reaction. The molecular dynamic simulations performed on K. albida mTGase have suggested some explanations to the higher specificity of this enzyme than MTGase, experimentally demonstrated by Steffen et colleague, and several indications to change the activity conditions used to test it. Moreover, the substrates screening has allowed to find novel possible substrates, on which this enzyme could be employed for the allergenicity reduction. On the other hand, the enzyme extracted from SaNDy, showing a higher similarity with MTGase, could be less selective than K. albida mTGase for specific substrates, so it could be possible its application also on the gliadin substrate, but to prove it further experiments are necessary. Note: the present PhD work has been mainly performed in the Bioinformatics Laboratory at the CNR of Avellino under Dr. Facchiano’s supervision, however all the MD simulations have been performed at the Biochemistry Department of the University of Zurich, in the computational and structural biology laboratory under the supervision of Prof. A. Caflisch and his research group (compulsory abroad training period). Experimental activity assays on gliadin substrate have been performed by the spectrometry mass CeSMA-ProBio lab at the CNR of Avellino; and the hypothetical mTGase from SaNDy was instead cloned, expressed and purified in collaboration with the Laboratory for Molecular Sensing at the CNR of Avellino.
GIRAUDO, MARTINA. "Passive shielding of space radiation for human exploration missions - Simulations and Radiation Tests." Doctoral thesis, Politecnico di Torino, 2018. http://hdl.handle.net/11583/2711122.
Повний текст джерелаNoetscher, Gregory Michael. "The VHP-F Computational Phantom and its Applications for Electromagnetic Simulations." Digital WPI, 2014. https://digitalcommons.wpi.edu/etd-dissertations/237.
Повний текст джерелаKleiven, Svein. "Finite Element Modeling of the Human Head." Doctoral thesis, KTH, Farkost- och flygteknik, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3347.
Повний текст джерелаQC 20100428
Ginsburger, Kévin. "Modeling and simulation of the diffusion MRI signal from human brain white matter to decode its microstructure and produce an anatomic atlas at high fields (3T)." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS158/document.
Повний текст джерелаDiffusion Magnetic Resonance Imaging of water in the brain has proven very useful to establish a cartography of brain connections. It is the only in vivo modality to study anatomical connectivity. A few years ago, it has been shown that diffusion MRI is also a unique tool to perform virtual biopsy of cerebral tissues. However, most of current analytical models (AxCaliber, ActiveAx, CHARMED) employed for the estimation of white matter microstructure rely upon a basic modeling of white matter, with axons represented by simple cylinders and extra-axonal diffusion assumed to be Gaussian. First, a more physically plausible analytical model of the human brain white matter accounting for the time-dependence of the diffusion process in the extra-axonal space was developed for Oscillating Gradient Spin Echo (OGSE) sequence signals. A decoding tool enabling to solve the inverse problem of estimating the parameters of the white matter microstructure from the OGSE-weighted diffusion MRI signal was designed using a robust optimization scheme for parameter estimation. Second, a Big Data approach was designed to further improve the brain microstructure decoding. All the simulation tools necessary to construct computational models of brain tissues were developed in the frame of this thesis. An algorithm creating realistic white matter tissue numerical phantoms based on a spherical meshing of cell shapes was designed, enabling to generate a massive amount of virtual voxels in a computationally efficient way thanks to a GPU-based implementation. An ultra-fast simulation tool of the water molecules diffusion process in those virtual voxels was designed, enabling to generate synthetic diffusion MRI signal for each virtual voxel. A dictionary of virtual voxels containing a huge set of geometrical configurations present in white matter was built. This dictionary contained virtual voxels with varying degrees of axonal beading, a swelling of the axonal membrane which occurs after strokes and other pathologies. The set of synthetic signals and associated geometrical configurations of the corresponding voxels was used as a training data set for a machine learning algorithm designed to decode white matter microstructure from the diffusion MRI signal and estimate the degree of axonal beading. This decoder showed encouraging regression results on unknown simulated data, showing the potential of the presented approach to characterize the microstructure of healthy and injured brain tissues in vivo. The microstructure decoding tools developed during this thesis will in particular be used to characterize white matter tissue microstructural parameters (axonal density, mean axonal diameter, glial density, mean glial cells diameter, microvascular density ) in short and long bundles. The simulation tools developed in the frame of this thesis will enable the construction of a probabilistic atlas of the white matter bundles microstructural parameters, using a mean propagator based diffeomorphic registration tool also designed in the frame of this thesis to register each individual
Fan, Xuelong. "Kinematic analysis of traumatic brain injuries in boxing using finite element simulations." Thesis, KTH, Medicinsk teknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-192526.
Повний текст джерелаINOUE, ISAO. "On the Generalization of Non-Adjacent Dependencies : The Discrepancy between SRN Simulations and Human Behavior." 名古屋大学大学院国際言語文化研究科, 2006. http://hdl.handle.net/2237/7845.
Повний текст джерелаWojtusch, Janis [Verfasser], Oskar von [Akademischer Betreuer] Stryk, and André [Akademischer Betreuer] Seyfarth. "Uncertainty and Sensitivity in Human Motion Dynamics Simulations / Janis Wojtusch ; Oskar von Stryk, André Seyfarth." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2018. http://d-nb.info/1162275103/34.
Повний текст джерелаMania, Aikaterini Katerina. "Fidelity metrics for virtual environment simulations based on human judgements of spatial memory awareness states." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369799.
Повний текст джерелаToulgoat, Isabelle. "Modélisation du comportement humain dans les simulations de combat naval." Phd thesis, Université du Sud Toulon Var, 2011. http://tel.archives-ouvertes.fr/tel-00626811.
Повний текст джерелаMiyawaki, Shinjiro. "Automatic construction and meshing of multiscale image-based human airway models for simulations of aerosol delivery." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1990.
Повний текст джерелаMESCHINI, VALENTINA. "Fluid-structure interaction in the left ventricle of the human heart: numerical simulations and experimental validation." Doctoral thesis, Gran Sasso Science Institute, 2017. http://hdl.handle.net/20.500.12571/9691.
Повний текст джерелаDeram, Aurelien. "Environnement générique pour la validation de simulations médicales." Phd thesis, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-00793236.
Повний текст джерелаWong, Yuna Huh. "Ignoring the innocent non-combatants in urban operations and in military models and simulations /." Santa Monica, CA : RAND, 2006. http://www.rand.org/pubs/rgsd_issertations/RGSD201/.
Повний текст джерелаDaouacher, Maria. "Evaluation of occupant kinematics in crash using the PIPER model : in frontal and oblique crash simulations." Thesis, Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-74250.
Повний текст джерелаNOTARANGELO, Girolama. "Asymptotic mean-square stability analysis and simulations of a stochastic model for the human immune response with memory." Doctoral thesis, Università degli studi di Ferrara, 2011. http://hdl.handle.net/11392/2388820.
Повний текст джерелаKillen, Bryce A. "Muscular stabilisation of the knee and development of automated and tuned subject-specific musculoskeletal models for gait simulations." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/387282.
Повний текст джерелаThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School Allied Health Sciences
Griffith Health
Full Text
Hirschberg, Jens. "Simulations of mechanical adaptation and their relationship to stress bearing in skeletal tissue." University of Western Australia. School of Anatomy and Human Biology, 2005. http://theses.library.uwa.edu.au/adt-WU2005.0095.
Повний текст джерелаCalmet, Hadrien. "Large-scale CFD and micro-particles simulations in a large human airways under sniff condition and drug delivery application." Doctoral thesis, Universitat Politècnica de Catalunya, 2020. http://hdl.handle.net/10803/670232.
Повний текст джерелаEn una inhalación, el aire que atraviesa nuestra cavidad nasal es sometido a una serie de aceleraciones y deceleraciones al producirse un giros, bifurcaciones y recombinarse de nuevo antes de volver a dividirse de nuevo a la altura de la tráquea en la entrada a los bronquios principales. La descripción precisa y acurada del comportamiento dinámico de este fluido así como el transporte de partículas inhalada que entran con el mismo a través de una simulación computacional supone un gran desafío. La dinámica del fluido en las vías respiratorias durante una inhalación rápida y corta (también llamado sniff) es un ejemplo perfecto de lo que sería probablemente la inhalación en el ser humano más compleja y violenta. Combinando la solución del fluido con un modelo lagrangiano revela el comportamiento del flujo y el effecto de la geometría de las vías respiratorias sobre la deposición de micropartículas inhaladas. La dinámica de fluidos computacional a gran escala de alta precisión permite resolver todas las escalas espaciales y temporales gracias al uso de recursos computacionales masivos. Un código de elementos finitos paralelos que se ejecuta en supercomputadoras puede resolver las ecuaciones transitorias e incompresibles de Navier-Stokes. Considerando que la malla más fina contiene 350 millones de elementos, cabe señalar que el presente estudio establece un precedente para simulaciones a gran escala de las vías respiratorias, proponiendo una estrategia de análisis para flujo medio, fluctuaciones, tensiones de corte de pared, espectro de energía y deposición de partículas en el contexto de una inhalación rápida y corta. Una vez realizado el analisis anterior, propondremos un estudio de administración de fármacos con un spray nasal en una cavidad nasal humana bajo diferentes condiciones de inhalación; sniff, caudal constante y respiración sostenida. Las partículas se introdujeron en el fluido con condiciones iniciales de pulverización, incluido el ángulo del cono de pulverización, el ángulo de inserción y la velocidad inicial. El diseño del atomizador del spray nasal determina las condiciones de partículas, entonces se utilizaron quince distribuciones de tamaño de partícula, cada uno definido por una distribución logarítmica normal con una media de volumen diferente. Esta tesis demuestra el potencial de las simulaciones a gran escala para una mejor comprensión de los mecanismos fisiológicos de las vías respiratorias. Gracias a estas herramientas se podrá mejorar el diagnóstico y sus respectivos tratamientos ya que con ellas se profundizará en la comprensión del flujo que recorre las vías aereas así como el transporte de aerosoles terapéuticos.
Agarwala, Vineeta. "Integrating empirical data and population genetic simulations to study the genetic architecture of type 2 diabetes." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11120.
Повний текст джерелаMaas, Ramona [Verfasser], Sigrid [Akademischer Betreuer] Leyendecker, Oliver [Akademischer Betreuer] Röhrle, and Jorge A. C. [Akademischer Betreuer] Ambrósio. "Biomechanics and optimal control simulations of the human upper extremity / Ramona Maas. Gutachter: Sigrid Leyendecker ; Oliver Röhrle ; Jorge A.C. Ambrósio." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2014. http://d-nb.info/1075477530/34.
Повний текст джерелаPesce, Luca [Verfasser], Paolo Akademischer Betreuer] Carloni, Carsten [Akademischer Betreuer] [Honerkamp, and Rachel [Akademischer Betreuer] Nechushtai. "Molecular simulations studies on human NEET proteins, novel targets for pharmaceutical intervention / Luca Pesce ; Paolo Carloni, Carsten Honerkamp, Rachel Nechushtai." Aachen : Universitätsbibliothek der RWTH Aachen, 2019. http://nbn-resolving.de/urn:nbn:de:101:1-2020091006430609584041.
Повний текст джерелаNicolaï, Adrien. "Conformational dynamics and free-energy landscape of human and E.coli Hsp70 chaperones from all-atom and coarse-grained numerical simulations." Thesis, Dijon, 2012. http://www.theses.fr/2012DIJOS060.
Повний текст джерелаThe 70 kDa heat shock proteins [Hsp70s] are key molecular chaperones which assist in the correct folding of nascent proteins and refolding of proteins under stress conditions in the intracellular environment. Hsp70s are present in all organisms and are highly conserved between the different species. [...] The conformational dynamics between the two conformations is governed by the ATP binding, ATP hydrolysis and by nucleotide exchange through an allosteric mechanism which is not fully understood.Knowledge of the conformations of hHsp70 at the atomic level is central to understand the interactions between its NBD and SBD. However, no complete structure of hHsp70 is known. In the present thesis, we report two conformations of hHsp70, constructed by homology modeling from the yeast Saccharomyces cerevisiae co-chaperone protein Hsp110 [openconformation] and from the bacteria Escherichia coli Hsp70 [closed conformation]. The open and closed conformations of hHsp70 built by homology were relaxed by using unbiased all-atom molecular dynamics [MD] simulations at 300 K in explicit solvent on a timescale of 2.7 and 0.5 μs, respectively. The conformational heterogeneity of hHsp70 observed in MD simulations was comparedwith those extracted from single-molecule Forster resonance energy transfer [FRET]experiments and to small-angle X-ray scattering [SAXS] data of Hsp70 homologs. [...] In the present thesis, the transitions between the open and closed conformation of Hsp70s were studied by using two different computational methods: the Normal Mode Analysis [NMA] and a new method developed in the present thesis based on the Free-Energy Landscape [FEL] concept.[...] These collective modes provide a mechanistic representation of the communication between the NBD and the SBD and allow us to identify subdomains and residues that appear to have a critical role in the conformational dynamics of Hsp70s in the harmonicapproximation. Second, in order to understand how the nucleotide binding in the NBD of Hsp70 induces a conformational change of the whole protein, we performed unbiased all-atom MD simulations [2 μs] of E. coli Hsp70 [named E. Coli DnaK], in three different nucleotide-binding states [ATPbound,ADP-bound and nucleotide free]. [...] Finally, by combining the NMA and the FEL analysis, we established a list of the local structures and of the residues relevant for the conformational dynamics and for the interdomain communication in hHsp70. Most of these residues could be related to previous experimental evidences of their role in the interdomain communication between the NBD and SBD domains of Hsp70 homologs but other were never identified before. All the relevant residues found in MD could be tested experimentally by mutational analysis and could be crucial locations to dock small peptides and for the design of inhibitors for the cancer therapy
Pesce, Luca Verfasser], Paolo [Akademischer Betreuer] Carloni, Carsten [Akademischer Betreuer] [Honerkamp, and Rachel [Akademischer Betreuer] Nechushtai. "Molecular simulations studies on human NEET proteins, novel targets for pharmaceutical intervention / Luca Pesce ; Paolo Carloni, Carsten Honerkamp, Rachel Nechushtai." Aachen : Universitätsbibliothek der RWTH Aachen, 2019. http://d-nb.info/1217415971/34.
Повний текст джерелаFierro, Fabrizio Verfasser], Paolo [Akademischer Betreuer] Carloni, and Marc [Akademischer Betreuer] [Spehr. "Human chemosensory G-protein coupled receptors : insight into agonist binding from bioinformatics and multiscale simulations / Fabrizio Fierro ; Paolo Carloni, Marc Spehr." Aachen : Universitätsbibliothek der RWTH Aachen, 2019. http://d-nb.info/1193181550/34.
Повний текст джерелаFierro, Fabrizio [Verfasser], Paolo Akademischer Betreuer] Carloni, and Marc [Akademischer Betreuer] [Spehr. "Human chemosensory G-protein coupled receptors : insight into agonist binding from bioinformatics and multiscale simulations / Fabrizio Fierro ; Paolo Carloni, Marc Spehr." Aachen : Universitätsbibliothek der RWTH Aachen, 2019. http://d-nb.info/1193181550/34.
Повний текст джерелаMiddlebrooks, Sam E. "Experimental Interrogation Of Network Simulation Models Of Human Task And Workload Performance In A U.S. Army Tactical Operations Center." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/34429.
Повний текст джерелаMaster of Science
Pybus, Oliveras Marc 1985. "Detection and classification of positive selection in human populations." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/384314.
Повний текст джерелаLa detecció de selecció positiva en regions genòmiques ha estat un tema recurrent en molts estudis de genètica de poblacions humanes. En conseqüència, durant els últims anys s'han publicat molts mètodes estadístics per detectar els senyals genòmics creats per un procés de selecció molecular. No obstant això, en general hi ha poca consistència entre les regions detectades pels diferents mètodes: dinàmiques demogràfiques especifiques de població, propietats locals de les regions analitzades o diferents tipus de selecció actuant a diferents marcs temporals i intensitats podrien explicar aquestes discrepàncies. Aquesta tesi doctoral està centrada en l'estudi d'aquest problema i en el desenvolupament d'una solució: un mètode de classificació de selecció positiva basat en algoritmes d'aprenentatge automàtic. El mètode combina diferents tests per detectar selecció positiva per obtenir informació sobre el tipus i mode de selecció que afecta una regió genòmica determinada. Aquest nou mètode presenta una alta sensitivitat cap a senyals de selecció positiva i és capaç de proveir informació sobre l'edat del esdeveniment selectiu, així com del seu estat final. Aquest treball millora la forma en què la selecció positiva és detectada avui en dia i proporciona una explicació a la falta de consistència observada entre els mètodes de detecció de selecció positiva quan s'apliquen en dades reals.
Whiteley, Chris G., and Duu-Jong Lee. "Computer simulations of the interaction of human immunodeficiency virus (HIV) aspartic protease with spherical gold nanoparticles: implications in acquired immunodeficiency syndrome (AIDS)." IOP Publishing Ltd, 2016. http://hdl.handle.net/10962/67083.
Повний текст джерелаThe interaction of gold nanoparticles (AuNP) with human immune-deficiency virus aspartic protease (HIVPR) is modelled using a regime of molecular dynamics simulations. The simulations of the 'docking', first as a rigid-body complex, and eventually through flexible-fit analysis, creates 36 different complexes from four initial orientations of the nanoparticle strategically positioned around the surface of the enzyme. The structural deviations of the enzymes from the initial x-ray crystal structure during each docking simulation are assessed by comparative analysis of secondary structural elements, root mean square deviations, B-factors, interactive bonding energies, dihedral angles, radius of gyration (R g), circular dichroism (CD), volume occupied by C α , electrostatic potentials, solvation energies and hydrophobicities. Normalisation of the data narrows the selection from the initial 36 to one 'final' probable structure. It is concluded that, after computer simulations on each of the 36 initial complexes incorporating the 12 different biophysical techniques, the top five complexes are the same no matter which technique is explored. The significance of the present work is an expansion of an earlier study on the molecular dynamic simulation for the interaction of HIVPR with silver nanoparticles. This work is supported by experimental evidence since the initial 'orientation' of the AgNP with the enzyme is the same as the 'final' AuNP-HIVPR complex generated in the present study. The findings will provide insight into the forces of the binding of the HIVPR to AuNP. It is anticipated that the protocol developed in this study will act as a standard process for the interaction of any nanoparticle with any biomedical target.
Sjöblom, Björn. "To do what we usually do : An ethnomethodological investigation of intensive care simulations." Thesis, Linköping University, Department of Computer and Information Science, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-6382.
Повний текст джерелаSimulators provide great promises of pedagogical utility in a wide array of practices. This study focuses on the use of a full-scale mannequin simulator in training of personnel at an intensive care unit at a Swedish hospital. In medicine, simulators are a means of doing realistic training without risks for the patient. Simulators for use in intensive care medicine are built to resemble as closely as possible the human physiology. In the studied sessions the simulator (a Laerdal SimMan) is set up to be an as-authentic-as-possible replication of the nurses regular, day-to-day practice.
In examining the training-sessions, it was found that the participants often did other things than “proper” simulation, such as joking or making comments about the simulation. These “transgressional activities” were studied from a perspective of ethnomethodology, using video-recordings of the session. These were transcribed and analyzed in detail using ethnomethodologically informed interaction analysis.
Several themes were developed from the recordings and transcripts. These have in common that they demonstrate the participants’ own achievement and maintenance of the simulation as a distinct activity. The analysis provides an account of how the local order of the simulation is upheld, how it is breached and how the participants find their way back into doing “proper” simulation. It is an overview of the interactional methods that participants utilize to accomplish the simulation as a simulation.
This study concludes with a discussion of how this study can provide a more nuanced view of simulations, in particular the relation between simulated and “real” practices. Notions of realism, authenticity and fidelity in simulations can all be seen to be the participants’ own concern, which informs their activities in the simulation.
Ryan, Steven Francis. "Fatigue Simulation of Human Cortical Bone using Non-Homogeneous Finite Element Models to Examine the Importance of Sizing Factors on Damage Laws." Thesis, Virginia Tech, 2006. http://hdl.handle.net/10919/33067.
Повний текст джерелаNon-homogeneous finite element models were created from micro computed tomography (CT) images of dumbbell shaped fatigue samples. An automatic voxel meshing technique was used which converted the CT data directly into mesh geometry and material properties.
My results showed that including these sizing factors improved the accuracy of the fatigue simulations on the non-homogeneous models. Using the Nelder-Mead optimization routine, I optimized the sizing factors for a group of 5 models. When these optimized sizing factors were applied to other models they improved the accuracy of the simulations but not as much as for the original models, but they improved the results more than with no sizing factors at all. I found that in our fatigue simulations we could account for the effects of stressed volume and inhomogeneity by including sizing factors in the life and damaging laws.
Master of Science