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1

Tracana, Rosa Branca, and Graça S. Carvalho. "Ecosystems, Pollution, and Use of Resources in Textbooks of 14 Countries: An Ecocentric Emphasis." ISRN Education 2012 (January 29, 2012): 1–5. http://dx.doi.org/10.5402/2012/419782.

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Анотація:
Two views of Human-Nature relation can be found: anthropocentrism and ecocentrism. In order to understand how school textbooks refer to the human’s position in nature we analysed how “Human as guest versus Humans as owners of nature” is present in the three topics of environmental education—Ecosystems, Pollution, and Use of Resource—in textbooks of 14 countries from Europe, Africa, and Middle East. A specific grid of analysis, which was constructed in the context of the European Project BIOHEAD-CITIZEN, was used in this study. Results show that this axis of analysis is present in the majority of textbooks addressing the above three topics but not in the “Biodiversity” topic. Textbooks for 12–15-year old pupils were the ones having more occurrences than those for 6–11- or 16–18-year olds. The textbooks present mainly an ecocentric position, whereas the aesthetic, ethical, and cultural aspects are limited and inadequate, limiting the full perspective of education for sustainable development.
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2

Muhammad Azwan Sulaiman, Adilah Binti Yusof, Muhammad Nazim Alias, and Mohamad Isa Abdullah. "A Study on Affordable Housing Issues Among Middle-Income Groups (M40) in Malaysia." Insight Journal 8 (April 7, 2021): 73–90. http://dx.doi.org/10.24191/ij.v8i0.98.

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Анотація:
Owning a house is an essential part of a human’s fundamental needs. The establishment of affordable housing that is adequate in number and fulfills liveable home standards is the major challenge in housing issues. Previous studies have found that the current interventions are insufficient in allowing average Malaysians to buy a home. The affordable housing-related issues that arise in Malaysia are not about the number of affordable houses in the market; however, it is about the availability of these houses for the middle-income groups. This study aims to investigate the issues and challenges faced by the middle-income group in dealing with affordable housing issues. This study is based on data from a survey questionnaire adapted from a past research which was similar in terms of affordable housing issues among middle-income earners. The data were analyzed and evaluated to rank the issues and provide recommendations. The findings suggest the establishment of an affordable housing agency to track and process affordable housing applications and approvals. The study results also suggest revising and improving the current affordable housing systems to help the middle-income groups to eventually own their first home. It is anticipated that the study can unravel the problems with affordable housing in this country.
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3

Malyk, Yu, T. Semeniuk, and N. Penteleichuk. "Microscopic and ultramicroscopic structure of typical chordae tendineae of the human’s left ventricle bicuspid valve." Bukovinian Medical Herald 25, no. 1(97) (May 26, 2021): 68–74. http://dx.doi.org/10.24061/2413-0737.xxv.1.97.2021.10.

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Objective – to determine the features of the micro- and submicroscopic structure of typical chordae tendineae of the mitral valve of the human heart.Materials and methods. This study was made on preparations of 35 human hearts, in particular the chordae tendineae of the bicuspid valves of the left ventricles of children and people of early and middle adulthood using the methods of light and electron microscopy.Results. The study of typical chordae tendineae of the mitral valve leaflets was made using the microscopic method and the method of electron microscopy. The areas where the chordae tendineae diverge from the papillary muscles, the middle third of the chordae tendineae, and the place of attachment of the chordae tendineae to the mitral valve leaflets were studied. Chordae tendineae are covered with endothelium from all sides. A peripheral collagen-elastic layer of loose fibrous connective tissue is localized under the endothelium, along the entire perimeter of the chordae tendineae and it differs in structure in different parts of the chordae at the submicroscopic level. Bundles of densely packed collagen fibers, which are oriented rectilinearly along the chordae, form the core of the chordae tendineae. Bundles of striated cardiac typical muscle cells are localized in areas where the chordae tendineae origin from the papillary muscles. It was found that in the composition of the chordae tendineae of children the cellular component in the fibrous connective tissue predominates during comparing the typical chordae tendineae of different aged people.Conclusions. This morphological study made it possible to obtain new information and to clarify the data that are already known to morphologists on the micro- and submicroscopic structure of typical chordae tendineae of the mitral valve of the human heart. We found that differences in the histological structure are more typical for the areas of origin of typical chordae tendineae from the papillary muscles and areas of their attachment to the leaflets of the mitral valve. The diameter of the core of the chordae tendineae increases and the thickness of the loose peripheral collagen-elastic layer decreases with age. The received data can serve as a theoretical basis for the further comparative morphological and clinical studies of the mitral valve of the human heart. That, in turn, will facilitate to an increasing the level of diagnostic, to improve methods of prevention and treatment of minor heart anomalies, congenital and acquired defects of the valvular apparatus of the heart.
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4

Wesołowska, Paula. "Body image and quality of life for middle-age men practicing long-distance running." Studies in Sport Humanities 27 (December 9, 2020): 21–27. http://dx.doi.org/10.5604/01.3001.0014.6095.

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Анотація:
Physical activity is an integral part of a healthy lifestyle, regardless of an individual human’s stage of life. The aim of the study was to investigate the relationship between long-distance running and body image,as well as quality of life amongmiddle-aged Polish men practicing long distance-running. Furthermore, the study was aimed at comparing their group in terms of the above variables with the group of men not undertaking physical activity. The study was conducted in 2018 among 220 men. The research tool consisted of: an original personal survey, the Body Scale Image and the Shortened Version of the WHOQOL-BREF (The World Health Organization Quality of Life) Survey. It has been shown that practicing physical activity aff ects the perception of one’s body among men in the middle of adulthood, while its impact on the sense of quality of life has not been confi rmed. It has been proven that men who practice long-distance running diff er signifi cantly in the perception of their own body from men not performing any physical activity.
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5

Ndeye, Maurice, Demba Kebe, Matar Sene, and Adama Harouna Athie. "Revision of the human’s occupations chronologies at the Senegalese and Mauritania sites by using marine reservoir ages corrections." Geochronometria 48, no. 1 (January 1, 2021): 16–30. http://dx.doi.org/10.2478/geochr-2021-0002.

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Анотація:
Abstract The prehistoric settlement of the west coast of the Senegalese-Mauritanian basin is established from archaeological remains and coal samples collected, sometimes in a stratigraphic context. However, the chronology issued, in the Before Present (BP) age, does not take into account the taphonomic context of the sites and the local reservoir age. Therefore, this article revisits the chronologies obtained based on the 14C literature and dating(s) acquired. Changes in time and duration of human occupancy of the area are shorter or longer depending on adequate yields of local reservoir age (Ndeye, 2008), which is a relevant element for marine samples. Thus, the archaeological implications observed with the reservoir effect are the rejuvenation or ageing of the dates, the age of the sites, the duration of occupation prehistoric or historical sites studied. Using the calibration programmes, it is noted that for the site of Senegal (Khant), without taking into account the reservoir effect, the human occupation is a priori, from the fifth millennium (Ancient Neolithic) to the third millennium BC (Middle Neolithic). However, if this marine reservoir effect is applied, the chronological periodisation goes from the fourth millennium to the first millennium. For the Mauritanian sites, the reservoir age correction is necessary for the Chami site while for the Tintan site is not required. Therefore, the calibrated archaeological chronologies obtained after the application of the marine reservoir effect are more relevant.
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6

Karamzin, A. M., and N. M. Tereshin. "GASTROINTESTINAL MICROBIOTA AND OBESITY. APPROVING PROBIOTICS AS DRUGS FOR TREATMENT OF OBESITY." Journal of microbiology epidemiology immunobiology, no. 1 (February 28, 2018): 112–19. http://dx.doi.org/10.36233/0372-9311-2018-1-112-119.

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Анотація:
Once considered as a problem only in high income countries, overweight and obesity now rise in low- and middle-income countries, particularly in urban settings. This situation accelerates the development of different approaches to investigation of obesity, makes the medical community look for new approaches to investigation of the obesity. Human’s microbiome is an imprescriptible part of it. Nevertheless it’s energetic function wasn’t fully appraised. Microbiome takes part in shorty chain fatty acids metabolism. Bacterial cells provide over 70% of daily energy for enterocytes, it’s part in general metabolism takes over 10%. ScFA can change activity of adenosine monophosphate-dependent protein kinase, stimulate leptin synthesis. Microbiome regulates synthesis of glucagon-like peptide, which has contrinsular effect. Right composition of microbiome reduces non-specific inflammation, produces isomers of linoleic acid, which can cause reduction of inflammation too. This article appraises probiotics as drugs for treatment to obesity and eradication of some conditions that can arise during obesity (atherosclerosis, hypertension, depression).
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7

Wang, Miao, and Bo Li. "Research on the Application of ASMR in the Development and Design of Sleeping Products." E3S Web of Conferences 179 (2020): 02061. http://dx.doi.org/10.1051/e3sconf/202017902061.

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Анотація:
Sleep is an important basis to keep human’s health and physiological activity. But nowadays, sleep disorders, depression, anxiety has become a social problem. Both young and middle-aged people face frequent health problems. In order to improve the sleep quality of the urban population and effectively alleviate the influence of a bad mood before sleep on sleep quality. Through the use of Autonomous Sensory Meridian Response (AMSR) induces a sensory phenomenon to help sleep, combine this new experience with the design, according to the features of this sensory phenomenon formulate a sleeping product scheme, discovering the new way to help to ease symptoms of sleep disorders. Through comparative experiments, test the sleep time of the target population, it is utilized to compare the sleeping time of the subjects after the application of the product. Analyse the feasibility and effectiveness of the product. The result showed that apply this product, 66% of the subjects reported that it was good to sleep, the validity of this method is proved.
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8

Rubel, V. "«NEOLITHIC REVOLUTION» IN BIBLICAL DESCRIPTION: ATTEMPT OF GEOGRAPHICAL AND CHRONOLOGICAL IDENTIFICATION." Bulletin of Taras Shevchenko National University of Kyiv. History, no. 136 (2018): 63–66. http://dx.doi.org/10.17721/1728-2640.2018.136.1.13.

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Анотація:
The stories of paradise garden, first men living in it, their fall and exile from Eden are fixed in the Bible and considered a sphere of religious and mythological, but not a historical component of the Holy Scripture. Textual analysis of the second chapter of «The Book of Genesis» gives grounds to consider Eden a real geographical object, which limits correspond to the territories of today’s Tabriz Valley. Description of paradise garden, where Adam, created by God, was not aware of death and was richly fed, not making any additional efforts, is a peculiar human memory of an era of early pre-Neolithic being. «The exile from Eden» – is an era in history, when «unproblematic» life of primitive men was finished because of lack of the natural resourses, quantity of which was deficient for survival. It made people to occupy territories beyond the original range of their existence. The second result of «the exile from paradise» was a curse of Adam, as since then he had to get food «by the sweat of his brow». Modern scientific terminology calls it «Neolithic revolution», i.e. transition from the foraging to the agriculture, when human had to master the art of tilling for growing food. Inverse chronological calculation method of generations of biblical patriarchs allows to date this historical fracture by the first half – the middle of III millennium BC. The third result of «the exile from paradise» was declared loss of human’s immortality. The emergence of reproductive economy, when a person began to plow the ground, dig channels, build dams, pasture livestock and in such way «get the daily bread», intensified the development of protoscientific knowledge, which resulted in human’s awareness of finality of his personal physical existence. The Bible redefines this fact as the loss of «eternity» by human.
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9

Vidwans, Ruddhida R., and Manendra Babu Lankadasari. "COVID-19: A Centennial Pandemic from Origin to Clinical Trials." Acta Biologica Marisiensis 3, no. 1 (June 1, 2020): 30–52. http://dx.doi.org/10.2478/abmj-2020-0003.

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Анотація:
AbstractIn December 2019, an unexpected interaction of coronavirus with human’s occurred for the third time in history after Severe Acute Respiratory Syndrome (SARS) in 2002-2003 and Middle East Respiratory Syndrome (MERS) in 2012. Soon the virus was confirmed as SARS-CoV-2, and the severity of its transmission lead the World Health Organization to declare it as World Pandemic. Due to its highly contagious nature, new methods like social distancing, self-hygiene and quarantine were being adopted by many countries to halt the transmission. Due to the dearth in specific therapeutics and/or vaccines against Coronavirus Disease (COVID-19), a significant thrust in drugs and vaccine discovery was ratified by all the nations. The current review comprehensively details about the emergence and molecular pathogenesis with an interesting timeline which notes all the major events during this crisis. Given the potential general readers and health workers, the symptoms and diagnostic approaches were simplified. Emphasis was given to therapeutic approaches and clinical trials section to support the translational research and to cope up with the viral outbreak.
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10

Pramasto, Arafah. "Kritik terhadap Pemikiran Kontroversial Bercorak Panteistik di Tengah Umat Islam dalam Karya Syaikh Abdus Shamad Al-Palimbani Abad ke-18." SINDANG: Jurnal Pendidikan Sejarah dan Kajian Sejarah 2, no. 1 (January 31, 2020): 8–18. http://dx.doi.org/10.31540/sindang.v2i1.823.

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Анотація:
Sufism is a philosophy that emerged among Muslims in 9th. Century A.D. It emphasises on the concept of bathiniya (esoteric) in the practicing of Islam. Among several figures propagating Sufism, two of them were Al-Hallaj in Middle East and Sheikh Siti Jenar in Indonesian Archipelago. Both were accused of spreading ideas of Panhteism (i.e. belief in Allah and his creations as one entity), which consequently resulted in Sufism being considered ‘Heresy’ and a ‘Stray idea’ by the orthodox Muslims. Sheikh Abdus Shamad Al-Palimbani, a Sufi Ulema born in Palembang (1737 AD) wrote critiques for Sufism in his three writings. The first book called ‘Kitab Hidayatus Shalikin’ in which he said that Allah is different with his creation. The second book, ‘Kitab Tuhfah Ar-Raghibin’ in which he rejected the concept of ‘Hulul’ (i.e. the belief that Allah is in creation), and lastly the ‘Kitab Siyarus Salikin’ that explored human’s awarness of their ‘lust’ which he believed is a gateway to understand the distinction between Allah’s divine reality and human existence.
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11

Enkhbold, N., Shi Dazhao, N. Batsaikhan, Deng Wang, D. Tseveendorj, and B. Erdenetuya. "STUDY ON THE DISTRIBUTION AND HABITAT CHARACTERISTICS OF BRANDT’S VOLE." Mongolian Journal of Agricultural Sciences 13, no. 2 (June 22, 2015): 88–95. http://dx.doi.org/10.5564/mjas.v13i2.524.

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Анотація:
Many species have suffered changed habitable area due to recent climate change or/and human activities. Brandt’s vole (Lasiopodomys brandtii) is same as it.The species is undergoing a continuous habitat change as a consequence of the human’s production, climate change and retrogressive succession of grassland ecosystems. The distribution of the Brandt’s vole was update in China and Mongolia. Based on the historical distribution map, which was made by overlaying the historical data with vegetation type’s map of the grassland resources in China and Mongolia. And the distribution map was modified according to the on-site investigate data in recent years. The current species’ distribution was range Hulunbei’er, northern Xilinguole, which comprise a landscape through the east of Dornod Aimag, Mongolia, and southern Hunshandake Sandy Land in China which just includes the areas around the Zhengxiangbai Qi. There were no the species in the east of Daxinganling Mountains, Liaoning, Shanxi province and Xinjiang Uyghur Autonomous Region of China. The species’ distribution is discontinuous in Mongolia, including western, middle and eastern Mongolia. The western distribution along Hangay Mountains and extends for the west, the northern boundary extended to between Ider river and Chulouk river. Southward reaches of the Malhin along the plain between Hangay Mountain and Altay Mountain. The middle and east of the species’ range lie in the part areas of Tov, Hentiy, Dundgovi, Dornogovi. extends to Hulunbei’er and northern Xilinguole eastwardly and southwardly respectively, northward reaches of the Trans-Baikalia, Russia.Mongolian Journal of Agricultural Sciences Vol.13(2) 2014: 88-95
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12

Naida, Sergey А., Nataliia Volodimirivna Bogdanova, O. R. Kyrylchyk, and S. I. Tolkach. "The method of express-control of the norm of an acoustic mechanical system of the human’s middle ear and a computer ear echoscopy for its implementation." Electronics and Communications 19, no. 3 (June 24, 2014): 32–37. http://dx.doi.org/10.20535/2312-1807.2014.19.3.141472.

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13

Azizmohammad, Fatemeh, and Atieh Rafati. "A Comparative Study of Isabel Allende “Ines of My Soul” and Gabriel Garcia Marquez “Love in the Time of Cholera” from the View Point of Features of Magic Realism." English Language and Literature Studies 8, no. 1 (February 8, 2018): 57. http://dx.doi.org/10.5539/ells.v8n1p57.

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Анотація:
This tentative study suggests Isabel Allende “Ines of my soul” and Gabriel Garcia Marquez “Love in the Time of Cholera” from magic realism point of view. Magic Realism is a Latin American literary movement which attempts to depict the reality in human’s mind. This literary movement is originated in the Latin American’s fiction in the middle of twentieth century. Isabel Allende, who is famous because in the most of her novels the magic realism is used, depicts the life of Ines Suarez, without whom the settlement of Chile could not be achieved, in the historical novel “Ines of my soul”.The father of magic realist writers, Gabriel Garcia Marquez in “Love in the time of cholera”, depicts the inside and outside worlds of man in this world, with the using of magic realism, he wants to show these opposites clearly.In this study, firstly, a model of analysis will be assumed by the features of magic realism. Next, Allende’s and Marquez’s novels will be read and analyzed within the magic realism pattern, the magic realism’s features will be traced in the novel. Finally, possible implications of both the model and the findings of the research for literary criticism and teaching novels of this kind will be discussed.
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14

Maharany, Gundara Tiara, Martinus Pasaribu, and Andar Bagus Sriwarno. "The Study of Gaze Movement Patterns in Identifying Toilet Sign Pictorial Forms Using Eye Tracking." IMOVICCON Conference Proceeding 1, no. 1 (July 3, 2019): 116–22. http://dx.doi.org/10.37312/imoviccon.v1i1.13.

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Анотація:
People’s confusion in interpreting the gender of the toilet sign has caused a hesitation to the people in determining the toilet’s cubicle. In this study, the toilet’s pictorial sign were examined and depicted as stylized forms of men and women. The aim of this research is to collect the data of the people’s eye gaze movement in order to identify the toilet’s sign system. Other related data were also collected through literature to obtain the theories that support the study. Three volunteers were participated in this study. In the first experiment, they had to identify 6 signs with different shapes presented at the same location with their central visual field using an “Eye-tracking” device without being told in advance. In the second experiment, they had to mention the type of gender in the three pairs of 6 toilet signs displayed. The result of the study indicated a difference between the pattern of human’s eyes movements in observing the sign unconsciously and the zoning at the middle represented as the “body” was the most viewed part. This research is expected to provide informations and references for academics, designers and governments in order to create sign system and universal design services.
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15

Khaksari, Razieh, Zambri Harun, Les Fielding, and John Aldridge. "Numerical Simulation of the Evacuation Process in a Tunnel during Contraflow Traffic Operations." Symmetry 13, no. 12 (December 11, 2021): 2392. http://dx.doi.org/10.3390/sym13122392.

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Анотація:
The purpose of this numerical research is to assess the evacuation process in a tunnel under the contraflow condition. Numerical simulations utilizing FDS+Evac codes associated with a fire dynamic simulator (FDS) model simulating a fire scenario are used to simulate evacuation and to predict the impact of a 100 MW fire scenario on the occupants inside the tunnel. Traffic and passenger conditions are based on real data from a tunnel in the UK. Two fire loads, 100 MW and 5 MW, are studied to represent an HGV and a passenger car fire. The 100 MW fire source, caused by an unexpected heavy good vehicle (HGV) catching fire, is located in the middle of the tunnel and at 20% of tunnel length to study the effect of fire source location on the usage of emergency exits and tenability thresholds. The dimensions and the inclination angle of the existing roadway tunnel are 1836 m (L) × 7.3 m (W) × 5 m (H) and 4%, respectively. It should be noted that the 4% inclination of the tunnel causes asymmetry propagation of smokes thus the visibility of the downstream and upstream from the fire behave differently. The maximum needed time to evacuate using all egress, the amount of fractional effective dose and visibility at the human’s height are analyzed. Simulation results indicate that when a realistic worst-case fire scenario is modeled, all evacuees can survive before the combustion gases and heat influence their survivability.
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16

Levitsky, V. S. "The Logic of the West’s History: Three Ages." Observatory of Culture 15, no. 3 (August 19, 2018): 260–70. http://dx.doi.org/10.25281/2072-3156-2018-15-3-260-270.

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Анотація:
The postmodern turn of the last quarter of the twentieth century, which consisted in a fi - nal rejection of metanarratives, makes great philosophical systems one of the areas of mythological narratives. However, this fact does not mean we do not have to comprehend the modern situation, which has become an inalienable attribute of modern identity. In this way, generalized metaphors, generalizing our knowledge at the intuitive level of aesthetic perception, become more and more important. From this philosophical and metaphorical instrumentation’s point of view, the history of the West can be schematically described in the form of three ages, symbolized, respectively, by the Mind (intelligence), the Reason, and the Sensuality, each of them having their own unique system-forming meanings that suggest relevant cultural practices. The Mind, or the age of Antiquity, affi rms the identity of the unconcealed in reality with the ontological basis of the existing — the cosmic mind. The Christian Middle Ages raise the line between the world of divine archetypes and sinful empirism. The Reason becomes human’s symbol and destiny. The new age or Modernity focuses on what is happening here and right now, brings reality to the momentary and pragmatic, and therefore can be described as the age of Sensuality. Thus, the logic of the West’s history, understood in this way, allows us to look at the whole historical process from a new perspective, at the same time opposing it (the logic) to the classical view, which became classical in the times of M. Weber, on history as on an ongoing process of disenchantment, the result of which is the mankind teleologically moving towards the incarnation of formal rationality.
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17

Suzuki, J., K. Kodera, and N. Yanagihara. "Middle Ear Implant for Humans." Acta Oto-Laryngologica 99, no. 3-4 (January 1985): 313–17. http://dx.doi.org/10.3109/00016488509108915.

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18

Rightmire, G. P. "Middle pleistocene humans from africa." Human Evolution 15, no. 1-2 (January 2000): 63–74. http://dx.doi.org/10.1007/bf02436235.

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19

Khusanova, Khayriniso. "“Middle age” as Prime Time of Human Life." International Journal of Psychosocial Rehabilitation 24, no. 02 (February 20, 2020): 332–37. http://dx.doi.org/10.37200/ijpr/v24i2/pr200340.

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20

Arsuaga, J. L., J. M. Carretero, C. Lorenzo, A. Gracia, I. Martı́nez, J. M. Bermúdez de Castro, and E. Carbonell. "Size Variation in Middle Pleistocene Humans." Science 277, no. 5329 (August 22, 1997): 1086–88. http://dx.doi.org/10.1126/science.277.5329.1086.

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21

Liang, Naixin, Si Chen, Yuting Yi, Yan-Fang Guan, Xuefeng Xia, and Xin Yi. "Characteristics of T-cell receptor repertoire between lung cancer patients and healthy people." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e20728-e20728. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e20728.

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Анотація:
e20728 Background: Deep sequencing studies on T cell receptor (TCR) repertoire have provided a wealth of information, such as immune status, virus infection history and so on. As we all known, the thymus begins to involute at the time of birth, so does the immune system. We can use TCR sequence to describe changes in human’s immune system with age, the difference between males and females and immune stat of cancers. Methods: We analyzed TCRβrepertoire in 334 healthy individuals without cancer, aged 2–83 years, and 207 lung cancers. In detail, genomic DNA was extracted from peripheral blood and used to amplified and sequenced the CDR3 region of rearranged TCRβ genes. Finally, we got the relative frequencies of individual T cell clones. Shannon’s entropy was calculated on the clonal abundance of all productive TCR sequences. The normalized Shannon’s entropy (Shannon index) was determined by dividing Shannon’s entropy by the natural logarithm of the number of unique productive TCR sequences. HEC was defined by a CDR3 aa clonotype clonal frequency exceeding 0.1%. Results: Analysis had been made to test the age relationship among a cluster of commonly used immune parameters, such as Shannon’s entropy, clonality and so on. Two outcomes, Shannon index and HEC, had showed a more closed correlation with age. Shannon indexs were significantly decreasing with age (p = 6.2×10-11), while HECs increased with age (p = 5.3×10-10) . Comparison of the peripheral blood T cell repertoire diversity between male and female, we found TCRβdiversity decreases more rapidly in 20 to 40 years for males than for females. No gender difference was observed in the youngest cohort and the oldest age cohort. Lung cancer patients has a lower T cell diversity compared with health people aged 40 years or more (6.43±1.30 vs 6.71±1.70, p = 6.3×10-5). Conclusions: Our data suggest that the human peripheral blood TCR repertoire diversity decrease from young ( < 20 years) to middle-aged ( 20 to 65 years ) to elderly adults ( > 65 years). Moreover, TCR repertoire displays significant gender difference in the 20-40 years age group. Lung cancer patients suffer a poorer immune state than healthy people.
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22

Rightmire, G. P. "Homo Erectus and Later Middle Pleistocene Humans." Annual Review of Anthropology 17, no. 1 (October 1988): 239–59. http://dx.doi.org/10.1146/annurev.an.17.100188.001323.

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23

Albiin, Nils, Lars-Eric Stenfors, Sten Hellström, and Anna Cerne. "Middle Ear Mucosa in Rats and Humans." Annals of Otology, Rhinology & Laryngology 95, no. 5_suppl (September 1986): 2–15. http://dx.doi.org/10.1177/00034894860950s501.

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Анотація:
The purposes of the study were a) to review thoroughly the literature and summarize it in a standardized fashion; b) to study the mucosa, including the distribution of mast cells, in all parts of the middle ear cavity in rats; and c) to compare the experimental findings with those known in humans. Adult, healthy rats were studied by light, scanning electron, and transmission electron microscopic techniques. The ciliated and secretory cells of the rat tympanic cavity are confined to two tracts, one anterior and one inferoposterior to the promontory. The tracts connect the epitympanum with the eustachian tube. The pars flaccida exhibits the highest density of mast cells, but mast cells are also distributed in the subepithelial layer of the tracts and in the floor of the tympanic bulla. The structure of the rat mucosa shows striking similarities to that of humans. Thus, from a morphological point of view, the rat seems to be a suitable model for middle ear studies. However, to be able to compare results obtained in different species and/or different laboratories, the areas of the middle ear from which the specimens have been taken must be carefully defined and presented in a standardized manner.
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24

Mishra, Gyan Prakash, ,. Mirza R. U. Beg, Shobha Bhatnagar, and Brijendra Singh. "VARIATIONS OF MIDDLE SEGMENTAL ARTERY OF HUMAN KIDNEY AND CLINICAL SIGNIFICANCE." International Journal of Anatomy and Research 3, no. 4 (November 30, 2015): 1551–54. http://dx.doi.org/10.16965/ijar.2015.278.

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25

Sugden, Andrew M. "Middle Stone Age humans in high-altitude Africa." Science 365, no. 6453 (August 8, 2019): 554.1–554. http://dx.doi.org/10.1126/science.365.6453.554-a.

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26

Witte, Emily, Yumei Liu, Jaimie L. Ward, Katie S. Kempf, Alicen Whitaker, Eric D. Vidoni, Jesse C. Craig, David C. Poole, and Sandra A. Billinger. "Exercise intensity and middle cerebral artery dynamics in humans." Respiratory Physiology & Neurobiology 262 (April 2019): 32–39. http://dx.doi.org/10.1016/j.resp.2019.01.013.

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27

Witte, Emily, Yumei Liu, Jaimie L. Ward, Katie S. Kempf, Alicen Whitaker, Eric D. Vidoni, Jesse C. Craig, David C. Poole, and Sandra A. Billinger. "Exercise Intensity and Middle Cerebral Artery Dynamics in Humans." Medicine & Science in Sports & Exercise 51, Supplement (June 2019): 132–33. http://dx.doi.org/10.1249/01.mss.0000560895.76382.1e.

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28

Sano, Shin-Ichi, Shin-Ichi Haruna, Patricia A. Schachern, and Michael M. Paparella. "Cytokeratin Patterns of Normal Middle Ear Epithelia in Humans, Cats, and Chinchillas." Annals of Otology, Rhinology & Laryngology 103, no. 3 (March 1994): 227–34. http://dx.doi.org/10.1177/000348949410300311.

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We describe the cytokeratin patterns of epithelia from the tympanic orifice, tympanic cavity, and mastoid cavity of humans, cats, and chinchillas, and compare these findings with those of tracheal epithelium and external canal epidermis. Our findings are as follows: 1) middle ear epithelium from all locations demonstrates some type of cytokeratin staining, 2) broad-spectrum cytokeratin antibodies stain epithelia of middle ear cleft, tracheal epithelium, and external canal epidermis in all species, 3) specific cytokeratin antibodies reveal species-related differences in middle ear and tracheal epithelia, 4) middle ear and tracheal epithelia usually have the same pattern, and 5) none of the monospecific cytokeratin antibodies have a positive reaction with external canal epidermis. These findings suggest that the cytokeratin patterns of middle ear epithelium are useful in studying the hyperplastic and metaplastic changes in otitis media; however, caution must be exercised when making interspecies comparisons.
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29

Syarifuddin. "Faith Level of Humans to God." Konfrontasi: Jurnal Kultural, Ekonomi dan Perubahan Sosial 8, no. 2 (July 2, 2021): 131–40. http://dx.doi.org/10.33258/konfrontasi2.v8i2.151.

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This study aims to determine the Faith Level of Humans to God. This study used qualitative research. The result of study shows that the level of human belief in going to God is strongly influenced by the reality of his daily religious life. Broadly speaking, it can be classified into three groups, namely the lay class, middle class and elite class. Each group has a different level of belief in Allah according to what he believes to be the standard or perception of Allah that he knows. This lay group is also classified into three groups, namely the lowest lay class, middle class and upper class. The Lowest Laity Group is called Muttabi, namely followers who only act taqlid without thinking. What is said by his religious guide is accepted raw, as it is. In the reality of religious life, the muttabi' group is the largest group. While the Confidence Level of the Middle Lay Group has the characteristic of merely understanding around mental problems to the extent that they can understand but not yet understanding the meaning and nature of inner knowledge itself. The limited space for movement in mental problems has increased to the hobby stage and has begun to not enable the mind for worldly things, it is not functioning properly. Meanwhile, the beliefs of the upper class Laymen are generally carried by the kiai. At this level the kiai have advantage because he has little ability guide the people in terms of the study of fiqh and monotheism physically and mentally. The knowledge of a kiyai only has the nuances of charisma, which is typical, namely obeying and doing all movements according to what he got from the previous teacher.
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30

Vennewald, I., J. Schönlebe, and E. Klemm. "Mycological and histological investigations in humans with middle ear infections*." Mycoses 46, no. 1-2 (February 2003): 12–18. http://dx.doi.org/10.1046/j.1439-0507.2003.00835.x.

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31

Bastir, Markus, Antonio Rosas, Daniel E. Lieberman, and Paul O'Higgins. "Middle Cranial Fossa Anatomy and the Origin of Modern Humans." Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 291, no. 2 (2008): 130–40. http://dx.doi.org/10.1002/ar.20636.

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32

Ruggero, Mario A., and Andrei N. Temchin. "Middle-ear transmission in humans: wide-band, not frequency-tuned?" Acoustics Research Letters Online 4, no. 2 (April 2003): 53–58. http://dx.doi.org/10.1121/1.1566924.

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33

Duprez, Thierry, Renaud Menten, Christine Saint-Martin, Naïma Deggouj, Monique Decat, and Guy Cosnard. "Imaging the middle-ear ossicles in humans: CT or MRI?" Pediatric Radiology 32, no. 2 (November 16, 2001): 102–3. http://dx.doi.org/10.1007/s00247-001-0586-2.

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34

Rodionov, Vladimir, Josef Elidan, Meir Nitzan, Mordechai Sela, and Haim Sohmer. "Vertical Plane Short and Middle Latency Vestibular Evoked Potentials in Humans." Annals of Otology, Rhinology & Laryngology 105, no. 1 (January 1996): 43–48. http://dx.doi.org/10.1177/000348949610500107.

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In order to determine whether short and middle latency vestibular evoked potentials (VsEPs) can be recorded in humans in response to angular acceleration stimuli in the vertical plane, a drum, head-holder, and stepper motor were designed to deliver upward acceleration impulses of 10,000°/s2 (1.8° displacement) to the human head. Forehead and mastoid electrodes recorded electrical activity that was filtered, differentially amplified, and averaged in short (12.7 milliseconds) and middle (63.5 milliseconds) latency time frames. Control recordings were used to eliminate various types of artifact. Recordings were conducted in 7 normal subjects and in 4 control patients with congenital, profound hearing loss and absence of caloric responses. Short and middle latency VsEPs with high intrasubject and intersubject consistency were recorded in normal subjects and not in control patients. The middle latency responses were larger in amplitude than the short latency responses. The effects of stimulus intensity and repetition rate on VsEP waveform, latency, and amplitude were studied. Experiments have shown that the responses are not electrical artifact, nor are they contaminated by auditory, somatosensory, or passive eye movement potentials.
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35

Sun, Xiu-zhen, Sheng Li, and Ying-xi Liu. "P-34 EFFECTS OF ANTERIOR MALLEAR LIGAMENT FIXATION ON HEARING IN HUMAN MIDDLE EAR MODEL." Proceedings of the Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics 2007.3 (2007): S122. http://dx.doi.org/10.1299/jsmeapbio.2007.3.s122.

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36

Shea, John J. "The Middle Paleolithic: Early Modern Humans and Neandertals in the Levant." Near Eastern Archaeology 64, no. 1-2 (March 2001): 38–64. http://dx.doi.org/10.2307/3210819.

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37

Burdukiewicz, Jan Michał. "The origin of symbolic behavior of Middle Palaeolithic humans: Recent controversies." Quaternary International 326-327 (April 2014): 398–405. http://dx.doi.org/10.1016/j.quaint.2013.08.042.

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38

Burrows, Dennis L., and S. Joseph Barry. "Electrophysiological evidence for the critical band in humans: Middle‐latency responses." Journal of the Acoustical Society of America 88, no. 1 (July 1990): 180–84. http://dx.doi.org/10.1121/1.399938.

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39

Verbree, J., AGT Bronzwaer, MA van Buchem, MJAP Daemen, JJ van Lieshout, and MJP van Osch. "Middle cerebral artery diameter changes during rhythmic handgrip exercise in humans." Journal of Cerebral Blood Flow & Metabolism 37, no. 8 (January 1, 2016): 2921–27. http://dx.doi.org/10.1177/0271678x16679419.

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Transcranial Doppler (TCD) sonography is a frequently employed technique for quantifying cerebral blood flow by assuming a constant arterial diameter. Given that exercise increases arterial pressure by sympathetic activation, we hypothesized that exercise might induce a change in the diameter of large cerebral arteries. Middle cerebral artery (MCA) cross-sectional area was assessed in response to handgrip exercise by direct magnetic resonance imaging (MRI) observations. Twenty healthy subjects (11 female) performed three 5 min bouts of rhythmic handgrip exercise at 60% maximum voluntary contraction, alternated with 5 min of rest. High-resolution 7 T MRI scans were acquired perpendicular to the MCA. Two blinded observers manually determined the MCA cross-sectional area. Sufficient image quality was obtained in 101 MCA-scans of 19 subjects (age-range 20–59 years). Mixed effects modelling showed that the MCA cross-sectional area decreased by 2.1 ± 0.8% (p = 0.01) during handgrip, while the heart rate increased by 11 ± 2% (p < 0.001) at constant end-tidal CO2 (p = 0.10). In conclusion, the present study showed a 2% decrease in MCA cross-sectional area during rhythmic handgrip exercise. This further strengthens the current concept of sympathetic control of large cerebral arteries, showing in vivo vasoconstriction during exercise-induced sympathetic activation. Moreover, care must be taken when interpreting TCD exercise studies as diameter constancy cannot be assumed.
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40

Alharbi, Naif Khalaf. "Vaccines against Middle East respiratory syndrome coronavirus for humans and camels." Reviews in Medical Virology 27, no. 2 (October 27, 2016): e1917. http://dx.doi.org/10.1002/rmv.1917.

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41

Aldhouse-Green, Stephen, Paul Pettitt, and Christopher Stringer. "Holocene humans at Pontnewydd and Cae Gronw caves." Antiquity 70, no. 268 (June 1996): 444–47. http://dx.doi.org/10.1017/s0003598x00083423.

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Pontnewydd, in north Wales, is known as a rare Middle Pleistocene site in northern Europe with human remains. Radiocarbon AMS dates identify human specimens, deriving from later use of the cave at Pontnewydd and its neighbour Cae Gronw, that have no part in its earlier story.
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42

Ebert, T. J., B. J. Morgan, J. A. Barney, T. Denahan, and J. J. Smith. "Effects of aging on baroreflex regulation of sympathetic activity in humans." American Journal of Physiology-Heart and Circulatory Physiology 263, no. 3 (September 1, 1992): H798—H803. http://dx.doi.org/10.1152/ajpheart.1992.263.3.h798.

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Arterial baroreflexes contribute importantly to blood pressure regulation through their influence on parasympathetic outflow to the sinus node and sympathetic outflow to the peripheral circulation. Baroreflex control of heart rate is known to be diminished in older individuals. Whether advancing age is associated with a parallel attenuation in baroreflex control of sympathetic outflow to the peripheral circulation has not been studied in humans. To provide such information, we made direct measurements of muscle sympathetic nerve activity (MSNA) in healthy males who ranged in age from 18 to 71 yr. The subjects were arbitrarily divided into three groups: younger (18–34 yr; n = 35), middle aged (35–50 yr; n = 15), and older (51–71 yr; n = 16). Although basal levels of MSNA were higher in older subjects than in younger and middle-aged subjects, the gains of baroreflex control of MSNA were the same in the older, middle-aged, and younger subjects (-4.6 +/- 0.6, -4.8 +/- 0.9, -5.1 +/- 0.5 U/mmHg, P greater than 0.10). In contrast, the gains of baroreflex control of cardiac intervals were attenuated in the older and middle-aged subjects compared with the younger subjects (9.8 +/- 1.2, 13.6 +/- 1.4, 21.7 +/- 1.3 ms/mmHg, P less than 0.05). Our data indicate that although the parasympathetic component of the arterial baroreflex becomes impaired with advancing age, the sympathetic component can be well maintained in healthy individuals even into the seventh decade.
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43

Niespolo, Elizabeth M., Warren D. Sharp, Graham Avery, and Todd E. Dawson. "Early, intensive marine resource exploitation by Middle Stone Age humans at Ysterfontein 1 rockshelter, South Africa." Proceedings of the National Academy of Sciences 118, no. 16 (April 12, 2021): e2020042118. http://dx.doi.org/10.1073/pnas.2020042118.

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Modern human behavioral innovations from the Middle Stone Age (MSA) include the earliest indicators of full coastal adaptation evidenced by shell middens, yet many MSA middens remain poorly dated. We apply 230Th/U burial dating to ostrich eggshells (OES) from Ysterfontein 1 (YFT1, Western Cape, South Africa), a stratified MSA shell midden. 230Th/U burial ages of YFT1 OES are relatively precise (median ± 2.7%), consistent with other age constraints, and preserve stratigraphic principles. Bayesian age–depth modeling indicates YFT1 was deposited between 119.9 to 113.1 thousand years ago (ka) (95% CI of model ages), and the entire 3.8 m thick midden may have accumulated within ∼2,300 y. Stable carbon, nitrogen, and oxygen isotopes of OES indicate that during occupation the local environment was dominated by C3 vegetation and was initially significantly wetter than at present but became drier and cooler with time. Integrating archaeological evidence with OES 230Th/U ages and stable isotopes shows the following: 1) YFT1 is the oldest shell midden known, providing minimum constraints on full coastal adaptation by ∼120 ka; 2) despite rapid sea-level drop and other climatic changes during occupation, relative shellfish proportions and sizes remain similar, suggesting adaptive foraging along a changing coastline; 3) the YFT1 lithic technocomplex is similar to other west coast assemblages but distinct from potentially synchronous industries along the southern African coast, suggesting human populations were fragmented between seasonal rainfall zones; and 4) accumulation rates (up to 1.8 m/ka) are much higher than previously observed for dated, stratified MSA middens, implying more intense site occupation akin to Later Stone Age middens.
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44

DeVan, Allison E., Daniel Umpierre, Michelle L. Harrison, Hsin-Fu Lin, Takashi Tarumi, Christopher P. Renzi, Mandeep Dhindsa, Stacy D. Hunter, and Hirofumi Tanaka. "Endothelial ischemia-reperfusion injury in humans: association with age and habitual exercise." American Journal of Physiology-Heart and Circulatory Physiology 300, no. 3 (March 2011): H813—H819. http://dx.doi.org/10.1152/ajpheart.00845.2010.

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Advancing age is a major risk factor for coronary artery disease. Endothelial dysfunction accompanied by increased oxidative stress and inflammation with aging may predispose older arteries to greater ischemia-reperfusion (I/R) injury. Because coronary artery ischemia cannot be induced safely, the effects of age and habitual endurance exercise on endothelial I/R injury have not been determined in humans. Using the brachial artery as a surrogate model of the coronary arteries, endothelial function, assessed by brachial artery flow-mediated dilation (FMD), was measured before and after 20 min of continuous forearm occlusion in young sedentary ( n = 10, 24 ± 2 yr) and middle-aged ( n = 9, 48 ± 2 yr) sedentary adults to gain insight into the effects of primary aging on endothelial I/R injury. Young ( n = 9, 25 ± 1 yr) and middle-aged endurance-trained ( n = 9, 50 ± 2 yr) adults were also studied to determine whether habitual exercise provides protection from I/R injury. Fifteen minutes after ischemic injury, FMD decreased significantly by 37% in young sedentary, 35% in young endurance-trained, 68% in middle-aged sedentary, and 50% in middle-aged endurance-trained subjects. FMD returned to baseline levels within 30 min in young sedentary and endurance-trained subjects but remained depressed in middle-aged sedentary and endurance-trained subjects. Circulating markers of antioxidant capacity and inflammation were not related to FMD. In conclusion, advancing age is associated with a greater magnitude and delayed recovery from endothelial I/R injury in humans. Habitual endurance exercise may provide partial protection to the endothelium against this form of I/R injury with advancing age.
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45

Iversen, HK. "Experimental Headache in Humans." Cephalalgia 15, no. 4 (August 1995): 281–87. http://dx.doi.org/10.1046/j.1468-2982.1995.1504281.x.

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The need for valid human experimental models of headache is obvious. Several compounds have been proposed as headache-inducing agents, but only the nitroglycerin (NTG) model has been validated. In healthy subjects, intravenous infusions of the nitric oxide (NO) donor NTG induce a dose-dependent headache and dilatation of the temporal, radial and middle cerebral artery. NTG-induced headache, although less intense, resembles migraine in pain characteristics, but the accompanying symptoms are rarely present. Cephalic large arteries are dilated during migraine headache as well as during NTG headache. N-acetylcysteine enhances the formation of NO and potentiates NTG-induced headache, whereas mepyramine, a H1-antagonist capable of blocking histamine-induced headache, has no effect. Thus, the headache is dependent on NO or other steps in the NO cascade. The model is useful for pharmacological interventions and sumatriptan reduced the NTG-induced headache. The NTG model may be a valuable tool in the development of future migraine drugs.
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46

Rodríguez-Vázquez, José Francisco. "The evidence in humans of ontogenic transfer of the incus to the middle ear." ANALES RANM 136, no. 03 (March 5, 2020): 283–86. http://dx.doi.org/10.32440/ar.2019.136.03.rev08.

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47

Lamers, Mart M., V. Stalin Raj, Mah’d Shafei, Sami Sheikh Ali, Sultan M. Abdallh, Mahmoud Gazo, Samer Nofal, et al. "Deletion Variants of Middle East Respiratory Syndrome Coronavirus from Humans, Jordan, 2015." Emerging Infectious Diseases 22, no. 4 (April 2016): 716–19. http://dx.doi.org/10.3201/eid2204.152065.

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48

Deiber, M. P., V. Ibanez, H. Bastuji, C. Fischer, and F. Mauguiere. "Changes of middle latency auditory evoked potentials during natural sleep in humans." Neurology 39, no. 6 (June 1, 1989): 806. http://dx.doi.org/10.1212/wnl.39.6.806.

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49

Magnuson, Leif Hergils, Bengt. "Nasal Gas Composition in Humans and its Implication on Middle Ear Pressure." Acta Oto-Laryngologica 118, no. 5 (January 1998): 697–700. http://dx.doi.org/10.1080/00016489850183205.

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50

Wahlgren, N. G., G. Hellström, C. Lindquist, and A. Rudehill. "Sympathetic Nerve Stimulation in Humans Increases Middle Cerebral Artery Blood Flow Velocity." Cerebrovascular Diseases 2, no. 6 (1992): 359–64. http://dx.doi.org/10.1159/000109067.

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