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Добірка наукової літератури з теми "HR-HPV (High-Risk Human Papillomavirus)"

Автор: Grafiati

Опубліковано: 10 березня 2023

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Статті в журналах з теми "HR-HPV (High-Risk Human Papillomavirus)"

OH, H. Y., M. K. KIM, S. SEO, D. O. LEE, Y. K. CHUNG, M. C. LIM, J. KIM, C. W. LEE, and S. PARK. "Alcohol consumption and persistent infection of high-risk human papillomavirus." Epidemiology and Infection 143, no. 7 (September 4, 2014): 1442–50. http://dx.doi.org/10.1017/s0950268814002258.

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SUMMARYAlcohol consumption is a possible co-factor of high-risk human papillomavirus (HR-HPV) persistence, a major step in cervical carcinogenesis, but the association between alcohol and continuous HPV infection remains unclear. This prospective study identified the association between alcohol consumption and HR-HPV persistence. Overall, 9230 women who underwent screening during 2002–2011 at the National Cancer Center, Korea were analysed in multivariate logistic regression. Current drinkers [odds ratio (OR) 2·49, 95% confidence interval (CI) 1·32–4·71] and drinkers for ⩾5 years (OR 2·33, 95% CI 1·17–4·63) had a higher risk of 2-year HR-HPV persistence (HPV positivity for 3 consecutive years) than non-drinkers and drinkers for <5 years, respectively (vs. HPV negativity for 3 consecutive years). A high drinking frequency (⩾twice/week) and a high beer intake (⩾3 glasses/occasion) had higher risks of 1-year (OR 1·80, 95% CI 1·01–3·36) HPV positivity for 2 consecutive years) and 2-year HR-HPV persistence (OR 3·62, 95% CI 1·35–9·75) than non-drinkers. Of the HPV-positive subjects enrolled, drinking habit (OR 2·68, 95% CI 1·10–6·51) and high consumption of beer or soju (⩾2 glasses/occasion; OR 2·90, 95% CI 1·06–7·98) increased the risk of 2-year consecutive or alternate HR-HPV positivity (vs. consecutive HPV negativity). These findings suggest that alcohol consumption might increase the risk of cervical HR-HPV persistence in Korean women.

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Mastutik, Gondo, Alphania Rahniayu, Dwi Murtiastutik, Afria Arista, Trisniartami Setyaningrum, Nabiha Missaoui, and Suhartono Taat Putra. "Distribution Genotype High Risk (HR) And Low Risk (LR) Human Papillomavirus (HPV) at Condyloma Acuminata." Biomolecular and Health Science Journal 4, no. 1 (June 30, 2021): 10. http://dx.doi.org/10.20473/bhsj.v4i1.26250.

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Introduction: Condyloma acuminata that is also known as genital warts are one of the most common sexually transmitted that caused by infection of Human papillomavirus (HPV). Persistent infection of Low Risk (LR) or High risk (HR) HPV is a risk factor for progress into benign or malignant cancer. The objective is to analyze distribution of genotype LR-HPV and HR-HPV at condyloma acuminata in anogenital region. Methods: A cross sectional study using were 36 lesions from men and women of condyloma acuminata patients. All subject signed the informed consent and ethic obtained from our institution, number 382/Panke.KKE/V/2016. The specimen was used to histopathological examination and to identified 40 genotypes of HPV using a reverse line blot assay.Results: The All patients were diagnosed as condyloma acuminata, some with focus dysplasia and koilocytosis. All patients were positive for HPV, including LR-HPV were HPV 6, 11, 42, 54, 61, 81,87,89 and HR-HPV were HPV 18, 26, 45, 51, 52, 66, 67, 68B, 69, 82. The single infection of LR-HPV was 44.4%, multiple infection LR/LR-HPV was 13,9% and the multiple infection of LR/HR-HPV was 41.7%. The LR-HPV infected 70,6% and HR-HPV infected 29,4%. Conclusion: LR-HPV is the major infection of condyloma acuminata, in single infection or multiple infection with HR-HPV. The most common infections were HPV 11, followed by HPV 6, HPV 18, HPV 51, and HPV 82. The determination of genotype of HPV can be used to predict the malignant transformation.

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Osorio, Julio C., Felipe Candia-Escobar, Alejandro H. Corvalán, Gloria M. Calaf, and Francisco Aguayo. "High-Risk Human Papillomavirus Infection in Lung Cancer: Mechanisms and Perspectives." Biology 11, no. 12 (November 23, 2022): 1691. http://dx.doi.org/10.3390/biology11121691.

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Lung cancer is a very prevalent and heterogeneous group of malignancies, and most of them are etiologically associated with tobacco smoking. However, viral infections have been detected in lung carcinomas, with high-risk human papillomaviruses (HR-HPVs) being among them. The role of HR-HPVs in lung cancer has been considered to be controversial. This issue is due to the highly variable presence of this virus in lung carcinomas worldwide, and the low viral load frequently that is detected. In this review, we address the epidemiological and mechanistic findings regarding the role of HR-HPVs in lung cancer. Some mechanisms of HR-HPV-mediated lung carcinogenesis have been proposed, including (i) HPV works as an independent carcinogen in non-smoker subjects; (ii) HPV cooperates with carcinogenic compounds present in tobacco smoke; (iii) HPV promotes initial alterations being after cleared by the immune system through a “hit and run” mechanism. Additional research is warranted to clarify the role of HPV in lung cancer.

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Chapman-Fredricks, Jennifer Rose, Maureen Cioffi-Lavina, Molly A. Accola, William M. Rehrauer, Monica T. Garcia-Buitrago, Carmen Gomez-Fernandez, Parvin Ganjei-Azar, and Mercè Jordà. "High-Risk Human Papillomavirus DNA Detected in Primary Squamous Cell Carcinoma of Urinary Bladder." Archives of Pathology & Laboratory Medicine 137, no. 8 (August 1, 2013): 1088–93. http://dx.doi.org/10.5858/arpa.2012-0122-oa.

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Context.—We reported previously that more than one-third (37%) of primary bladder squamous cell carcinomas (SCCs) demonstrate diffuse p16 immunoreactivity independent of gender. This observation made us question whether p16 overexpression in bladder carcinoma is due to human papillomavirus (HPV)–dependent mechanisms. Objectives.—To determine whether the presence of high-risk HPV (HR-HPV) DNA could be detected in these tumor cells. Design.—Fourteen cases of primary bladder SCC, which were positive for p16 by immunohistochemistry, were probed for the detection of HR-HPV by in situ hybridization and the signal amplification Invader assay. Samples positive for detection of HR-HPV by Invader assay were amplified by using HR-HPV type-specific primers, and amplification products were DNA sequenced. Results.—Detection of HR-HPV by the in situ hybridization method was negative in all cases (0 of 14). However, in 3 of 14 cases (21.4%), the presence of HR-HPV DNA was detected with the Cervista HPV HR Invader assay, which was followed by identification of genotype. All positive cases were confirmed by using HR-HPV type-specific amplification followed by DNA sequencing. Identified HR-HPV genotypes included HPV 16 (2 cases) and HPV 35 (1 case). Conclusions.—High-risk HPV DNA is detectable in a subset of primary bladder SCCs. Based on the well-documented carcinogenic potential of HR-HPV, there is a necessity for additional studies to investigate the role of HR-HPV in bladder carcinogenesis.

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Aguayo, Francisco, Juan P. Muñoz, Francisco Perez-Dominguez, Diego Carrillo-Beltrán, Carolina Oliva, Gloria M. Calaf, Rances Blanco, and Daniela Nuñez-Acurio. "High-Risk Human Papillomavirus and Tobacco Smoke Interactions in Epithelial Carcinogenesis." Cancers 12, no. 8 (August 6, 2020): 2201. http://dx.doi.org/10.3390/cancers12082201.

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Cervical, anogenital, and some head and neck cancers (HNC) are etiologically associated with high-risk human papillomavirus (HR-HPV) infection, even though additional cofactors are necessary. Epidemiological studies have established that tobacco smoke (TS) is a cofactor for cervical carcinogenesis because women who smoke are more susceptible to cervical cancer when compared to non-smokers. Even though such a relationship has not been established in HPV-related HNC, a group of HPV positive patients with this malignancy are smokers. TS is a complex mixture of more than 4500 chemical compounds and approximately 60 of them show oncogenic properties such as benzo[α]pyrene (BaP) and nitrosamines, among others. Some of these compounds have been evaluated for carcinogenesis through experimental settings in collaboration with HR-HPV. Here, we conducted a comprehensive review of the suggested molecular mechanisms involved in cooperation with both HR-HPV and TS for epithelial carcinogenesis. Furthermore, we propose interaction models in which TS collaborates with HR-HPV to promote epithelial cancer initiation, promotion, and progression. More studies are warranted to clarify interactions between oncogenic viruses and chemical or physical environmental factors for epithelial carcinogenesis.

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Almonte, Maribel, Catterina Ferreccio, Miguel Gonzales, Jose Manuel Delgado, C. Hilary Buckley, Silvana Luciani, Sylvia C. Robles, et al. "Risk Factors for High-Risk Human Papillomavirus Infection and Cofactors for High-Grade Cervical Disease in Peru." International Journal of Gynecologic Cancer 21, no. 9 (November 2011): 1654–63. http://dx.doi.org/10.1097/igc.0b013e3182288104.

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ObjectiveTo evaluate the association between potential risk factors for high-risk human papillomavirus (HR-HPV) infection and cofactors for cervical intraepithelial lesions grade 2 or worse (CIN2+) in women attending cervical screening in Amazonian Peru.Materials and MethodsParticipants completed a risk factor questionnaire before screening. High-risk human papillomavirus infection was determined by Hybrid Capture II. Logistic regression was used to evaluate associations between potential risk factors for HR-HPV infection and between cofactors and risk of CIN2+ among women with HR-HPV infection.ResultsScreening and questionnaires were completed by 5435 women aged 25 to 49 years. The prevalence of HR-HPV was 12.6% (95% confidence interval [CI], 11.8%–13.6%) and decreased by age. Early age at first sexual intercourse and several lifetime sexual partners increased the risk of having HR-HPV (age-adjusted odds ratio [AOR] of age at first sexual intercourse <18 vs ≥20, 1.5; 95% CI, 1.2–2.0; AOR of ≥5 lifetime sexual partners vs 1, 2.1; 95% CI, 1.4–3.2). Among women with HR-HPV infection, those with no schooling (AOR relative to 1–5 years of schooling, 3.2; 95% CI, 1.3–8.3) and those with parity ≥3 (AOR relative to parity <3, 2.6; 95% CI, 1.4–4.9) were at increased risk of CIN2+. The effect of parity was stronger for cancer (AOR of parity ≥3 vs <3, 8.3; 95% CI, 1.0–65.6). Further analysis showed that the association between parity and CIN2+ was restricted to women younger than 40. Most women (83%) had previously been screened. Sixty-four percent of CIN2+ cases detected in this study occurred in women who reported having had a Papanicolaou test in the previous 3 years. Only 4 of 20 cancers were detected in women never screened before. Having had a previous abnormal Papanicolaou test increased the risk of CIN2+ (OR, 16.1; 95% CI, 6.2–41.9).ConclusionAmong women with HR-HPV, high parity (in young women), no schooling, lack of good-quality screening and of adequate follow-up care are the main risk factors for high-grade cervical disease in Peru.

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Lv, Panpan, Fang Zhao, Xiaoqin Xu, Jun Xu, Qiang Wang, and Zhen Zhao. "Correlation between Common Lower Genital Tract Microbes and High-Risk Human Papillomavirus Infection." Canadian Journal of Infectious Diseases and Medical Microbiology 2019 (November 22, 2019): 1–6. http://dx.doi.org/10.1155/2019/9678104.

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Background. High-risk human papillomavirus (hr-HPV) infection is a necessary cause of cervical cancer. However, other common lower genital tract microbes may increase hr-HPV infection and their related cervical cytopathy. Methods. To confirm this hypothesis, cervical brush and vaginal swab specimens were collected from 826 adult patients who were divided into the hr-HPV-positive group (254) and the negative group (572) by real-time PCR assay. Cervical specimens were tested for Ureaplasma parvum (UP), Ureaplasma urealyticum (UU), and Chlamydia trachomatis (CT) using PCR analysis. Vaginal secretion was detected for Trichomonas vaginalis (TV), Candida spp., and bacterial vaginosis (BV) with conventional assay. Results. Among hr-HPV-positive women, UP was found in 51.6%, UU in 15.4%, CT in 15.7%, Candida spp. in 11.0%, TV in 3.1%, and BV in 20.5%. In the hr-HPV-negative group, UP was positive in 36.2%, UU in 8.6%, CT in 4.0%, Candida spp. in 12.4%, TV in 0.2%, and BV in 7.0%. Multivariate logistic regression analysis with age-adjusted showed that UU (OR, 1.757), UP (OR, 1.804), CT (OR, 3.538), BV (OR, 3.020), and TV (OR, 14.109) were risk factors on hr-HPV infection (P<0.05). Conclusion. These microbes might induce cervical chronic inflammation that would damage the mucosal barrier and immune protection to promote the infection of hr-HPV.

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Alhamlan, Fatimah Saeed, Ahmed A. Al-Qahtani, and Mohammed N. Al-Ahdal. "Current studies on human papillomavirus in Saudi Arabia." Journal of Infection in Developing Countries 9, no. 06 (July 4, 2015): 571–76. http://dx.doi.org/10.3855/jidc.6538.

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Human papillomavirus (HPV) infection is a significant etiological factor and an important prognosticator in cervical cancer. Indeed, researchers worldwide have confirmed these roles for high-risk HVPs in over 70% of cervical cancer cases. According to the World Health Organization, approximately 561,200 new cancer cases (5.2% of all new cancers) are attributed to HPV infection. Over 120 types of HPV are classified further as either low-risk HPV (LR-HPV) or high-risk HPV (HR-HPV) based on their oncological potential of transforming cells. The LR-HPV types cause benign hyperproliferative lesions (i.e. genital warts) while the HR-HPV types are strongly associated with premalignant and malignant cervical lesions. Data on the prevalence of HPV, survival of infected patients, and mortality rate are scarce in Saudi Arabia. The unsubstantiated assumption of a low prevalence of HPV in Saudi Arabia has contributed to limiting HPV research in this conservative country. Therefore, the goal of this review is to shed light on the current HPV research being conducted and the prevalence of HPV in Saudi Arabia.

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Liewchalermwong, Sasiprapa, Shina Oranratanaphan, Wichai Termrungruanglert, Surang Triratanachat, Patou Tantbirojn, Nakarin Kitkumthorn, Parvapan Bhattarakosol, and Arkom Chaiwongkot. "High-Risk Human Papillomavirus Detection via Cobas® 4800 and REBA HPV-ID® Assays." Viruses 14, no. 12 (December 3, 2022): 2713. http://dx.doi.org/10.3390/v14122713.

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Persistent infection with high-risk human papillomaviruses (HR-HPVs), particularly HPV16 and 18, has long been known to induce cervical cancer progression. However, given that a minority of HPV-infected women develop cancer, analysis of HR-HPV-infected women could help to predict who is at risk of acquiring cervical cancer. Therefore, to improve HR-HPVs detection, we used the FDA-approved cobas® 4800 HPV and REBA HPV-ID® HPV assays to detect HR-HPVs in colposcopy-derived cervical cells from 303 patients, detecting 72.28% (219) and 71.62% (217) of HR-HPVs positive cases, with HPV16 detection rates of 35.64% (108) and 30.69% (93), respectively. Of the HPV16-positive cases, cobas® 4800 and REBA HPV-ID® identified 28.81% (51) and 25.42% (45) of the CIN1 cases, and 55% (33) and 50% (30) of the 60 CIN2/3 cases, respectively. HPV-diagnostic concordance was 82.17% overall (kappa = 0.488), 87.45% for HR-HPVs (kappa = 0.689), and 88.33% for CIN2/3 (kappa = 0.51). The HR-HPVs detection rates of these assays were comparable. Our findings reveal that the FDA-approved HR-HPVs detection assay is appropriate for screening women with HR-HPVs infection, and for predicting increased risk of cervical cancer progression. REBA HPV-ID® can be used to detect low risk-HPV types in high-grade cervical lesions that are HR-HPV negative as well as in the distribution of HPV types.

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Ablanedo-Terrazas, Yuria, Karla Romero-Mora, María Gómez-Palacio, Claudia Alvarado-de la Barrera, Matilde Ruiz-Cruz, Ramón Hernández-Juan, and Gustavo Reyes-Terán. "Prevalence and risk factors for oral human papillomavirus infection in Mexican HIV-infected men." Salud Pública de México 60, no. 6, nov-dic (December 13, 2018): 653. http://dx.doi.org/10.21149/9834.

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Objective. To determine the prevalence and risk factors for oral high-risk human papillomavirus (HR-HPV) infection in human immunodeficiency virus (HIV)-infected men. Materials and methods. Consecutive male outpatients with HIV-infection were enrolled. Demographic and behavioral risk data were obtained. Anal swabs and oral rinses were tested for HR-HPV DNA. Oral, pharyngeal and video laryngoscopy examinations were performed for detection of lesions. Results. The prevalence of HR-HPV oral infection was 9.3% (subtypes other than HR HPV 16/18 predominated). The prevalence of anal HR-HPV infection was 75.7%. The risk factors for oral infection with HR-HPV were tonsillectomy (OR=13.12) and years from HIV diagnosis (OR=1.17). Conclusions. Tonsillectomy and years from HIV diagnosis were associated with oral HPV infection. No association was found between oral and anal HR-HPV infections. This is the first study reporting the prevalence and risk factors for oral HR-HPV infection in Mexican HIV-infected population.

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Більше джерел

Дисертації з теми "HR-HPV (High-Risk Human Papillomavirus)"

Cong, Duanduan. "Identification of functional single nucleotide polymorphisms (SNPs) in High Risk-Human Papillomavirus (HR-HPV) related diseases." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31174.

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Persistent infection of the cervix with high risk (HR) types of Human Papilloma Virus (HPV) (HR-HPV) can result in precancerous lesions and cancers. However, most HPV infections can be cleared naturally by the immune response without causing disease. Although genetic variations have long been considered as the main explanation for individual heterogeneity in cancer susceptibility, the underlying mechanisms remain unclear. In this project, a panel of routinely taken clinical samples was assessed for 32 rationally selected SNPs with allele frequency related to disease outcome using the Taqman® OpenArray® system. The panel incorporated 475 HR-HPV negative, cytologically-normal cervical samples, 413 HR-HPV positive cervical high grade squamous intraepithelial lesion (HSIL) cases and 62 HR-HPV positive cervical cancers. Two SNPs, rs2234671 and rs2623047, were found with significant differences between HR-HPV negative, cytologically-normal samples and HR-HPV positive cervical HSIL cases. In the validation step, these two SNPs were further genotyped in the same set of samples using TaqMan® SNP genotyping assay and/or LightSNiP assay and in additional samples including 83 HR-HPV positive, cytologically-normal cervical samples, 21 HR-HPV positive cervical cancer cases, 129 HR-HPV positive vulval intraepithelial neoplasia cases and 23 HR-HPV positive vulval cancer cases. Statistical analysis was then performed based on pooled and re-grouped genotyping data of the above-mentioned samples under different genetic models so as to evaluate the associations with different stages in the disease process. After validation, SULF1 rs2623047 revealed a strong significant association with the susceptibility to HR-HPV infection but not with the development of high-grade squamous intraepithelial lesion and the progression to cervical cancer. CXCR1 rs2234671, by contrast, was associated with the progression of HR-HPV-related cancers and the minor allele CXCR1 827C was significantly enriched in HPV16 positive cancers. CXCR1 is a receptor for the chemokine CXCL8/IL-8 and CXCR1 rs2234671 leads to a serine to threonine change in an extracellular loop of the receptor. Functionally, the CXCR1 827C allele was shown to enhance cell motility in response to IL-8 stimulation in a chemotaxis assay with transiently transfected fibroblasts (HEK293 cells) and also in a wound healing assay with stably transduced cervical cancer (CaSki) cells. In addition, significantly increased cell proliferation upon IL-8 treatment was observed in two cervical cancer derived cell lines, CaSki and SiHa, transduced with CXCR1-827C allele, but not in their CXCR1 827G transduced counterparts. These findings suggest that SULF1 rs2623047 and CXCR1 rs2234671 may be genetic risk factors for HR-HPV-related cervical disease and CXCR1 rs2234671 might affect HR-HPV-related cancer susceptibility by functionally altering IL-8-CXCR1 signalling. This information has potential for use in the risk stratification of HR-HPV infected women and may also suggest new therapeutic targets to be exploited for treatment of cervical cancer patients.

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Afrogheh, Amir. "The role of high-risk human papillomavirus in periocular cancers." University of the Western Cape, 2018. http://hdl.handle.net/11394/6554.

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Philosophiae Doctor - PhD
PURPOSE: High risk human papillomavirus (HR-HPV) is well established as a causative agent of squamous cell carcinoma (SCC) of the orophaynx. HR-HPV has also been reported in periocular cancers and precancers, but controversy exists about its overall incidence and clinicopathologic profile. The purpose of this study is to evaluate the role of HR-HPV infection in periocular cancers and precancers, using multiple methods of detection. DESIGN: Retrospective observational case series with laboratory investigations. METHODS: Sequential surgical samples of 87 carcinomas (invasive SCC, SCC in situ and sebaceous carcinoma) from three different periocular sites (conjunctiva, lacrimal sac and the eyelid) diagnosed over a 15-year period (2000-2015) were selected for evaluation. Unstained paraffin sections of 87 cases of periocular carcinomas were analyzed with immunohistochemistry (IHC) for p16 as a screening test. p16 positive conjunctival- and lacrimal sac SCC were further evaluated for HR-HPV using DNA in situ hybridization (DNA ISH), and a subset was also analyzed by DNA Polymerase Chain Reaction (DNA PCR). p16 positive periocular sebaceous carcinomas (SC) were analyzed with PCR, and a subset of 18cases was further studied with a novel method of mRNA ISH, an advanced technique with an enhanced sensitivity and specificity. Relevant patient clinical information was obtained from review of the electronic medical records.

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Afrogheh, Amir H. "The role of high-risk human papillomavirus in periocular cancers." University of the Western Cape, 2018. http://hdl.handle.net/11394/6528.

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Philosophiae Doctor - PhD
Purpose: High risk human papillomavirus (HR-HPV) is well established as a causative agent of squamous cell carcinoma (SCC) of the orophaynx. HR-HPV has also been reported in periocular cancers and precancers, but controversy exists about its overall incidence and clinicopathologic profile. The purpose of this study is to evaluate the role of HR-HPV infection in periocular cancers and precancers, using multiple methods of detection. Design: Retrospective observational case series with laboratory investigations. Methods: Sequential surgical samples of 87 carcinomas (invasive SCC, SCC in situ and sebaceous carcinoma) from three different periocular sites (conjunctiva, lacrimal sac and the eyelid) diagnosed over a 15-year period (2000-2015) were selected for evaluation. Unstained paraffin sections of 87 cases of periocular carcinomas were analyzed with immunohistochemistry (IHC) for p16 as a screening test. p16 positive conjunctival- and lacrimal sac SCC were further evaluated for HR-HPV using DNA in situ hybridization (DNA ISH), and a subset was also analyzed by DNA Polymerase Chain Reaction (DNA PCR). p16 positive periocular sebaceous carcinomas (SC) were analyzed with PCR, and a subset of 18cases was further studied with a novel method of mRNA ISH, an advanced technique with an enhanced sensitivity and specificity. Relevant patient clinical information was obtained from review of the electronic medical records.

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Eldakhakhny, Sahar. "Crosstalk between high-risk human papillomavirus E7 and p63 in cervical cancer." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/crosstalk-between-highrisk-human-papillomavirus-e7-and-p63-in-cervical-cancer(105b5422-2ef0-40a8-9209-0d1d89fb75c9).html.

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Introduction: Cervical cancer is the fourth most common malignancy diagnosed in women worldwide. It results from cellular transformation by the high-risk human papillomavirus (HPV) oncogenes E6 and E7, which accounts for more than 99% of diagnosed cases. HPV links its life cycle to epithelial proliferation and differentiation, which requires the cells to remain active in cell cycle. p63 modulates epithelial development as well as proliferation, differentiation and DNA damage response (DDR), which makes it an important target for HPV oncoproteins to allow viral replication and survival in infected cells. Methods: In this study, small interfering RNAs targeting E7 oncoprotein and p63 in the HPV16 positive cervical cancer cell line CaSki were used. Western blotting, proliferation assays, apoptosis assays and cell cycle analysis were applied to examine the effects of E7 and p63 depletion on cell fate. Overexpression of different types of HPV-E7 was performed in the N/Tert-1 keratinocyte cell line to study the effect of E7 overexpression on p63 level. Results: E7 drives the expression of p63 at both transcript and protein levels in cervical cancer cell lines. Downregulation of E7 is accompanied by a remarkable inhibition of cell proliferation and cell cycle arrest in the G0/G1 phase. Depletion of E7 is associated with a significant reduction in p63 expression which is not due to impaired proliferation or induced differentiation. Downregulation of p63 is associated with delayed DDR in cervical cancer cells following treatment with ionising radiation. High-risk HPV E7s are more potent in inducing p63 upregulation and increasing the proliferation rates in keratinocytes. Conclusion: This work for the first time demonstrated that E7 modulates the expression of p63, which regulates DNA damage repair pathways, that promotes efficient and rapid repair of the DNA damage following ionising radiation treatment in cervical cancer cells. Tumour recurrence due to resistance to radiotherapy is common, mostly due to promoted DNA repair ability of cancer cells to reduce radiation-induced toxicity and increase cell survival in response to ionising radiation. These findings might be the key to the development of radioresistance in cervical cancer. The HPV E7-p63 axis may be a novel therapeutic target to enhance radio-sensitivity in HPV-transformed tumours.

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Dreilich, Martin, Michael Bergqvist, Martin Moberg, Daniel Brattström, Inger Gustavsson, Stefan Bergström, Alkwin Wanders, Patrik Hesselius, Gunnar Wagenius, and Ulf Gyllensten. "High-risk human papilloma virus (HPV) and survival in patients with esophageal carcinoma : a pilot study." Uppsala universitet, Institutionen för onkologi, radiologi och klinisk immunologi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-94408.

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BACKGROUND: Human papilloma virus (HPV) in patients with esophageal carcinoma has previously been studied with an average detection rate of 15%, but the role of HPV in relation to survival is less clear. In cervical cancer, lung cancer and tonsil cancer HPV viral load is a predictive factor for survival and outcome of treatment. The primary aim was to study the spectrum of high-risk HPV types in esophageal tumors. Secondary, as a pilot study we investigated the association between HPV status and the survival rates. METHODS: We compared both the presence and the viral load of high-risk HPV types 16, 18, 31, 33, 39, 45, 52, 58, and 67 in relation to clinical data from patients with esophageal carcinoma. Survival data and tumor samples were retrieved from 100 patients receiving treatment at the Department of Oncology, Uppsala Hospital, Uppsala, Sweden. The tumor samples were investigated for HPV viral load using real-time PCR. RESULTS: HPV 16 was detected in 16% of the patients; no other HPV type was detected. HPV 16 infection had no significant effect on survival (p = 0.72). Also, HPV 16 did not improve survival after treatment (radiotherapy or chemotherapy). CONCLUSION: Only HPV 16 was detected among the patients. HPV 16 in esophageal carcinoma patients did not influence survival or improve therapy response. However, given the size of the study there is a need to examine a larger cohort in order to understand in more detail the effect of high risk HPV types in esophageal carcinoma.

De två första författarna delar förstaförfattarskapet.

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Johnson, Derek Christopher. "Prevalence and determinants of high risk human papillomavirus (HPV) among wives of migrant workers -- A study in Far-West Nepal." Thesis, The University of Alabama at Birmingham, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3719210.

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This dissertation research focuses on the risk factors associated with high-risk HPV infection (HR-HPV) and abnormal cervical cytology in Nepali women residing in Nepal’s Far-West district of Achham. The first part of this dissertation assesses the HR-HPV test concordance of self-collected vs. clinician-collected cervico-vaginal specimens. Of 261 women with both clinician- and self-collected cervical samples, 25 tested positive for HR-HPV, resulting in an overall HR-HPV prevalence of 9.6% (95% Confidence Interval [CI]: 6.3–13.8). The overall Kappa value for clinician- and self-collected tests was 0.64 (95% CI: 0.48–0.84), indicating a “good” level of agreement. The second part of this dissertation investigates the association between 251 women whose husband’s migrate for work and their high-risk HPV (HR-HPV) infection status and their abnormal cervical cytology status. Half of study participants (50.8%) had husbands who reported migrating for work at least once. Women 34 years and younger were significantly less likely to test positive for HR-HPV than women older than 34 years (OR 0.22, 95% CI 0.07–0.71). HR-HPV infection and abnormal cervical cytology status were not directly associated with a husband’s migration. The last part of this dissertation investigates the link between rates of sexually transmitted disease (STD) symptoms and geospatial differences among migrant workers using the Nepal Demographic Health Survey (NDHS). Data was restricted to 9,607 married women in the 2011 NDHS. Multivariate logistic regression models assessing the odds of reporting STD symptoms in the 2011 NDHS found that women whose husbands migrated for a year or more were more likely to report STD symptoms than women whose husbands were not currently migrating for work if they lived in Nepal’s Mid-West region (OR 1.93 95%CI 1.02–3.67) or Nepal’s Far-West region (OR 2.89 95%CI 1.24–6.73). The burden of increased risk factors for HR-HPV infection and abnormal cervical cytology could result in increases in HPV prevalence in the wives of Nepali migrant workers.

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O'Keefe, Elissa J., and n/a. "Young, sexually active, senior high school women in the australian Capital Territory: prevalence and risk factors for genital Human papillomavirus infection." University of Canberra. Health Sciences, 2004. http://erl.canberra.edu.au./public/adt-AUC20060410.140559.

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An association between persistent Human papillomavirus (HPV) infection in women and cervical cancer has been established. Young women are particularly at risk of acquiring sexually transmitted infections such as HPV because of risky sexual activity and physiological immaturity. While at risk though, young women have been shown to be amenable to health promoting initiatives. There are a small number of international studies concerning adolescent HPV infection and the risk factors associated with infection, but there is currently no evidence on the prevalence and risk factors for HPV in an Australian, sexually active female adolescent population. This study aimed to provide evidence of the prevalence of HPV, risk factors associated with infection and the patterns of sexual activity in a female sexually active, senior high school population in the Australian Capital Territory. Participants in this study were a convenience sample of 161 sexually active 16-19 year old females who had an HPV test who were attending a senior high school in the Australian Capital Territory. Nurses and doctors using a clinical record collected information about sexual and other risk behaviours. Self-obtained vaginal swabs were tested for HPV DNA using the polymerase chain reaction method and genotyping was undertaken. The HPV prevalence in this cohort of young women was 1 1.2%. High-risk genotypes were found in 55.5% and multiple genotypes were found in 38.8%. There was a significant association found between HPV infection and having had more than one male partner with whom vaginal intercourse had occurred in the previous six months. No statistically significant association was found between HPV and the age of coitarche, length of time young women had been sexually active, condom use, and smoking or alcohol intake. A young age at coitarche was common for this group. Smoking and alcohol use was seen in large proportions in this group. This is the first Australian study that has examined the prevalence and risk factors for genital HPV in this demographic group. The HPV prevalence is lower than in international studies in comparable groups, in similar age groups and much lower than in older women both in Australia and overseas. With the comparatively low prevalence comes an opportunity for important public health interventions for this group including routine Pap smears, vaccination against the high-risk types of HPV when this becomes available and strategies for young women to reduce their number of male sexual partners. A substantial amount of young women in this study were sexually active aged under 16 years. Whilst this was not identified as being a risk factor in this study, it is both a health and personal safety issue for these young women. There is a demonstrated need for health promotion strategies for this cohort about the consumption of safe levels of alcohol and for smoking cessation. Further research is recommended that includes a repetition of this study with a larger sample, the use of a prospective study design to identify trends in infection and examination of HPV prevalence and risk factors for a variety of populations.

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Konopnicki, Deborah. "Infection with high risk Human Papillomavirus (HRHPV) among HIV-positive women: epidemiology, natural history and impact of combined antiretroviral therapy." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209264.

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L’infection persistante par les papillomavirus (HPV) dits « à haut risque » induit le cancer du col. Chez les femmes infectées par le VIH, les infections par ces HPV oncogènes et les lésions associées, allant des dysplasies au cancer invasif, sont plus fréquentes, plus sévères et de moins bon pronostic que chez les femmes non porteuses du VIH. Etonnamment, alors qu’il a été clairement établi que l’importance de la pathologie liée à HPV est directement proportionnelle au degré d’immunodépression des patientes porteuses du VIH, il n’a pas pu être démontré qu’un traitement antirétroviral efficace contre le VIH permettant d’améliorer l’immunité, diminue l’infection par ces HPV.

Entre janvier 2002 et décembre 2012, nous avons constitué une cohorte prospective de dépistage et de suivi de l’infection cervicale par HPV à haut risque incluant plus de 900 femmes traitées à la consultation du Centre de Référence SIDA de l’hôpital Saint-Pierre. Nos résultats montrent que chez ces femmes pour la plupart d’origine Africaine et traitée avec succès pour le VIH depuis plusieurs années, la prévalence et l’incidence de l’infection par HPV oncogène sont beaucoup plus importantes que dans la population belge générale ou que chez les femmes séropositives vivant dans d’autres pays occidentaux. Grâce à un suivi longitudinal de plusieurs années, nous avons pu démontrer que le risque d’être infectée par un HPV oncogène est significativement réduit sous trithérapie anti-VIH sous réserve d’obtenir une charge virale indétectable à <50 cp/ml pendant plus de 3 ans ou une restauration immunitaire à >500 lymphocytes CD4+/µL pendant plus d’un an et demi. Ces résultats ont été confirmés dans l’analyse que nous avons faite sur les nombreuses dysplasies cervicales également retrouvées dans notre cohorte. Enfin, nous avons trouvé que la distribution des génotypes d’HPV de nos patientes est similaire à celle trouvée en Afrique sub-saharienne impliquant que la couverture offerte par les vaccins anti-HPV varie entre moins de 30% pour les vaccins bi- ou quadrivalent actuellement disponibles à 80% pour le vaccin nanovalent en développement. Notre travail met en lumière l’étendue particulièrement importante de l’infection par HPV à haut risque chez les femmes séropositives vivant en Belgique et offre de nouveaux éléments de réflexion afin d’adapter à leurs particularités les recommandations belges et les critères de remboursement à la fois pour le dépistage du cancer cervical et la vaccination anti-HPV.

Persistent infection with human papillomavirus (HPV) called “at high risk” induces cervical cancer. In HIV-positive women, infection with these oncogenic HPV and HPV-induced lesions ranging from cervical dysplasia to invasive cancer are more frequent, more severe and have a worst outcome than in HIV-negative women. An intriguing paradox is that, although it has been clearly demonstrated that high risk HPV infection and associated diseases are increased by progressive immune deficiency, the introduction of efficient therapy against HIV leading to improved immunity has not been associated with a decrease in oncogenic HPV infection or HPV-induced lesions.

Between January 2002 and December 2012, we have built a prospective cohort to screen and follow-up cervical infection by high risk HPV in more than 900 women treated for HIV in the AIDS Reference centre of Saint-Pierre Hospital. We have shown that among these women mainly from Sub-Saharan African origin and successfully treated for HIV for several years, the prevalence and incidence rate of high risk HPV are much higher than in the general population from Belgium or in HIV-positive women from other western countries. After several years of longitudinal follow up, we have demonstrated that the risk of infection by oncogenic HPV is significantly reduced by efficient therapy against HIV provided that HIV viral load has been sustainly suppressed below 50 cp/ml for more than 3 years or that immunity has been increased more than 500 CD4+T cells/µl for more than 1.5 years. These results have been confirmed in the analysis on cervical dysplasia which is also very prevalent in our cohort. At last, we have found that the HPV genotype distribution in our population is very similar to the one found in Sub-Saharan Africa. We have estimated that the coverage offered by the vaccines against HPV in our cohort is less than 30% for the currently available bi- or quadrivalent vaccine but reaches 80% with the future nanovalent vaccine. Our results highlight many differences in the HPV infection and associated diseases in HIV-positive women compared to HIV-negative women; these differences should be taken into account to adapt to our specific population the current Belgian guidelines or the reimbursement criteria on cervical screening and on vaccines against HPV.

Doctorat en Sciences médicales
info:eu-repo/semantics/nonPublished

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Hawes, Stephen Edward. "HIV-1, HIV-2, and dual infection with HIV-1 and HIV-2 are associated with increased risk for human papillomavirus (HPV) and high grade squamous intraepithelial lesions (HSIL) in Senegal, West Africa /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/10881.

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Nielson, Carrie. "Human Papillomavirus Prevalence in Asymptomatic Men." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/194193.

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Introduction: Human papillomavirus (HPV) is the sexually transmitted etiologic agent of cervical cancer. While HPV infects both men and women, little is known about HPV infection in men. Specifically, knowledge of the prevalence of type-specific HPV infection and the distribution of these infections by anogenital anatomic site in men is incomplete. Evaluation of factors associated with HPV infection based on complete anogenital sampling and with HPV-16 antibody detection may lead to a better understanding of HPV transmission and prevention.Methods: A total of 493 asymptomatic men ages 18 to 40 years old were recruited in Tucson, Arizona, and Tampa, Florida, from 2003 to 2006. Eligibility requirements included having had sex with a woman within the past year and having no history of genital warts. Testing for HPV from anogenital swabs from six anatomic sites and semen was conducted by PCR and reverse line blot genotyping for 37 HPV types. Serum antibodies for HPV-16 were detected by ELISA. Self-administered demographic, health, and sexual history/behavior questionnaires were collected. HPV prevalence and type distributions by anatomic site were calculated, as was seroprevalence of HPV-16 antibodies. Multivariate logistic regression was used to identify independent risk factors for HPV infection at any anatomic site and for having HPV-16 antibodies.Results: HPV was detected in at least one sample for 303 (65.4%) men, with 29.2% of men having an oncogenic infection and 36.3% having a non-oncogenic infection. Multiple HPV types were detected in 27.2% of men. Factors associated with infection were a greater lifetime number of female sexual partners, currently smoking 10 or more cigarettes per day, lack of condom use, and more sexual partners in the past three months. HPV-16 antibodies were detected in the serum of 63 (12.8%) men, and detection was associated with increasing age and concurrent detection of HPV DNA in perianal or anal canal samples.Discussion: The combination of more complete anogenital sampling and sensitive HPV detection for 37 HPV types resulted in a higher HPV prevalence in asymptomatic men than previously reported. Smoking and condom use were the most important modifiable risk factors for HPV in men. These results have implications for research of HPV transmission.

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Книги з теми "HR-HPV (High-Risk Human Papillomavirus)"

Sexually transmitted diseases sourcebook: Basic consumer health information about sexual health and the screening, diagnosis, treatment, and prevention of common sexually transmitted diseases (STDs), including chancroid, chlamydia, gonorrhea, herpes, hepatitis, human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), human papillomavirus (HPV), syphilis, and trichomoniasis ; along with facts about risk factors and complications, trends and disparities in infection rates, tips for discussing STDs with sexual partners, a glossary of related terms, and resources for additional help and information. 5th ed. Detroit, MI: Omnigraphics, Inc., 2013.

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Laura, Larsen, ed. Sexually transmitted diseases sourcebook: Basic consumer health information about the symptoms and treatment of chlamydia, gonorrhea, hepatitis, herpes, HIV/Aids, human papillomavirus (HPV), pelvic inflammatory disease, syphilis, trichomoniasis, vaginal infections, and other sexually transmitted diseases (STDs), including recent facts about prevalence, risk factors, diagnosis, treatment, and prevention; along with tips on discussing and living with STDs, updates on current research and vaccines, a glossary of related terms, and resources for additional help and information. 4th ed. Detroit, MI: Omnigraphics, Inc., 2009.

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Grulich, Andrew E., Fengyi Jin, and I. Mary Poynten. Anal Cancer. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0037.

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Anal canal cancer is a generally uncommon cancer that has been increasing in incidence for several decades. In most geographic locations, squamous cell carcinoma (SCC) accounts for 70% or more of cases, and incidence is slightly higher in women than in men. The remaining cases are mainly adenocarcinoma, but the degree to which this represents misclassified rectal cancer is uncertain. In almost all cases, anal SCC is caused by persistent infection with high-risk types of human papillomavirus (HPV); HPV-16 accounts for 75% or more of all cases. Survival is highly stage-dependent, and cure is usual if the cancer is diagnosed early. The main risk factor is anal exposure to HPV, and for this reason homosexual men are at particularly high risk. In women, risk is increased in those with higher numbers of sexual partners, and in those with a history of HPV-related disease at genital sites.

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Herrero, Rolando, and Raul Murillo. Cervical Cancer. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0048.

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Cervical cancer is the fourth most common cancer in women worldwide, with more than 500,000 cases and 250,000 deaths per year. The disease is characterized by marked regional differences, with more than 80% of the cases and deaths occurring in developing countries. The etiology and natural history of the disease are very well studied, with persistent infection with one of thirteen human papillomavirus (HPV) types now considered to be a necessary cause. The molecular mechanisms have also been elucidated and are mediated mainly by the expression of viral oncogenes that interfere with cellular pathways. The two most common HPV types, namely HPV-16 and HPV-18, are associated with about 70% of all cases around the world. Immunologic (e.g., HIV infection), hormonal (e.g., high parity), environmental (e.g., smoking), and genetic (e.g., HLA type) cofactors determine the risk of persistence and cancer among women harboring HPV infection.

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Madeleine, Margaret M., and Lisa G. Johnson. Vulvar and Vaginal Cancers. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0049.

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Vulvar and vaginal cancers are rare and predominantly involve squamous cell carcinomas. Some studies combine these cancers, presumably because of their rarity, anatomic proximity, and shared risk factors. Major risk factors include human papillomavirus (HPV) and cigarette smoking. This chapter explores the similarities and important differences in etiology between these cancer sites. In addition to its focus on invasive cancer, the chapter also discusses high-grade precursor lesions, or in situ disease, that sometimes progress to cancer and must, therefore, be treated.

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Frisch, Morten. Penile Cancer. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0055.

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Penile cancers are rare primary malignancies located on the glans, foreskin, or shaft of the penis, excluding the urethra. The vast majority of penile cancers are epithelial tumors representing histological subtypes of squamous cell carcinoma (SCC). Most penile SCCs are believed to develop through pre-invasive lesions known as penile intraepithelial neoplasia and penile carcinoma in situ. They account for 0.1%–0.3% of all incident cancers (excluding non-melanoma skin cancers) in the United States and other developed countries and up to 1% of all cancers in some countries in sub-Saharan Africa. Penile cancers are rare in men younger than 40 years, and are typically diagnosed among men above age 60. The two most important risk factors are pathological phimosis and infection with high-risk types of human papillomaviruses (HPV), both of which are preventable conditions.

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Franceschi, Silvia, Hashem B. El-Serag, David Forman, Robert Newton, and Martyn Plummer. Infectious Agents. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0024.

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Eleven infectious agents (seven viruses, three parasites, and one bacterium) have been classified by the International Agency for Research on Cancer as carcinogenic to humans for one or more cancer sites: hepatitis B virus; hepatitis C virus; thirteen types of human papillomavirus (HPV); human immunodeficiency virus type 1 (HIV-1); human T-cell leukemia virus type 1; Epstein-Barr virus; Kaposi sarcoma herpesvirus; Helicobacter pylori; Opisthorchis viverrini; Clonorchis sinensis; and Schistosoma haematobium. Other infectious agents, such as Merkel cell polyomavirus, Plasmodium falciparum, and cutaneous HPVs, have been classified as “probably carcinogenic” or “possibly carcinogenic.” Accurate biomarkers of chronic infection have been essential for estimating risk and ascribing a causal role to infectious agents in cancer. Of the 14 million cases of cancer estimated to have occurred worldwide in 2012, 2.2 million were caused by infectious agents. Vaccination and screen-and-treat programs have the potential for greatly reducing the burden of cancer caused by infections.

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Hashibe, Mia, Erich M. Sturgis, Jacques Ferlay, and Deborah M. Winn. Oral Cavity, Oropharynx, Lip, and Salivary Glands. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0029.

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Cancers of the oral cavity, oropharynx, lip, and salivary glands are malignancies of the head and neck. Some of these cancer sites share risk factors, although each has distinctive anatomic, epidemiologic, and clinical features. Oral cavity cancers arise on the inner lip and buccal mucosa, anterior two-thirds of the tongue, gum, hard palate, and floor of mouth. These cancers are strongly associated with the use of smoked and smokeless tobacco products, heavy alcohol consumption, and chewing of betel quid or pan, but only minimally associated with prior infection with human papillomavirus (HPV). In contrast, oropharyngeal cancers affect the posterior one-third (base) of the tongue, tonsils, soft palate, and other oropharyngeal tissues and are strongly associated with HPV-16 infection as well as with the use of tobacco, alcohol, and betel quid. In principle, tumors of the oral cavity, oropharynx, and lip are among the most preventable forms of cancer.

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Djajadiningrat, Rosa, and Simon Horenblas. Penile cancer. Edited by James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0093.

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Penile cancer is a rare malignancy in the Western world, but in Asia, Africa, and South Africa the incidence is much higher. Risk factors, including phimosis, human papillomavirus (HPV), smoking, chronic inflammatory conditions, psoralen ultraviolet photochemotherapy, genital warts, and HIV infection play a role in the pathogenesis of penile cancer. Approximately 95% of all penile tumours are squamous cell carcinomas (PSCC) and the large majority arise from the prepuce or glans. PSCC has a strong tendency for lymphatic dissemination, but cure can still be attained in patients with inguinal involvement. The most commonly used staging system is the 2009 TNM classification for penile cancer. Surgical resection has been the mainstay of treatment in penile carcinoma, including penile-preserving techniques, partial and total penectomy. The aim of surgery is minimizing loss of anatomy and function, without jeopardizing oncological results.

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Charles, Nicole. Suspicion. Duke University Press, 2021. http://dx.doi.org/10.1215/9781478022251.

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In 2014 Barbados introduced a vaccine to prevent certain strains of the human papillomavirus (HPV) and reduce the risk of cervical cancer in young women. Despite the disproportionate burden of cervical cancer in the Caribbean, many Afro-Barbadians chose not to immunize their daughters. In Suspicion, Nicole Charles reframes Afro-Barbadian vaccine refusal from a question of hesitancy to one of suspicion. Drawing on ethnographic fieldwork, black feminist theory, transnational feminist studies and science and technology studies, Charles foregrounds Afro-Barbadians' gut feelings and emotions and the lingering trauma of colonial and biopolitical violence. She shows that suspicion, far from being irrational, is a fraught and generative affective orientation grounded in concrete histories of mistrust of government and coercive medical practices foisted on colonized peoples. By contextualizing suspicion within these longer cultural and political histories, Charles troubles traditional narratives of vaccine hesitancy while offering new entry points into discussions on racialized biopolitics, neocolonialism, care, affect, and biomedicine across the Black diaspora. Duke University Press Scholars of Color First Book Award recipient

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Частини книг з теми "HR-HPV (High-Risk Human Papillomavirus)"

Golusinski, Pawel. "Risk Factors for Oral Infection with Human Papillomavirus." In HPV Infection in Head and Neck Cancer, 73–85. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-43580-0_5.

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Park, S. B., S. Hwang, and B. T. Zhang. "Mining the Risk Types of Human Papillomavirus (HPV) by AdaCost." In Lecture Notes in Computer Science, 403–12. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-540-45227-0_40.

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Kelsall, Stephen R., and Jerzy K. Kulski. "A Gene Cassette for High Level Expression of the Li Capsid Protein of HPV-16 in Heterologous Cells." In Immunology of Human Papillomaviruses, 51–54. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2449-6_9.

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Baezconde-Garbanati, Lourdes, Bibiana Martinez, Carol Ochoa, Sheila Murphy, Rosa Barahona, Carolina Aristizabal, and Yaneth L. Rodriguez. "Optimizing Engagement of the Latino Community in Cancer Research." In Advancing the Science of Cancer in Latinos, 101–13. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-14436-3_9.

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AbstractTo optimize engagement of Latino communities in cancer research, University of Southern California researchers are working with communities on prevention of cervical cancer, a highly preventable and treatable disease. Two recent studies from their signature initiatives, Es Tiempo and Tamale Lesson, are presented to illustrate the situation in the Latino community regarding the human papillomavirus (HPV) vaccination and cervical cancer screening. These population-based studies included promotores de salud (lay community health workers) and community members who were engaged from conceptualization, recruitment, translation, cultural adaptation, information dissemination, and other important aspects of the research. A third exploratory effort used virtual reality as a research tool to better understand vaccine hesitancy, especially among boys and explored end-of-life quality improvements for immigrant Latino populations. These studies serve as a backdrop for discussing common strategies to increase participation in cancer research in key areas such as information delivery, consultation with stakeholders and partners, and collaboration with community opinion leaders. Strategies are discussed, which optimize engagement in cancer research, stimulate communication, and empower participants to engage in research. These strategies shape attitudes, beliefs, and behaviors, improving outcomes for Latinas at risk of cervical and other HPV-related cancers.

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Eom, Jae-Hong, Seong-Bae Park, and Byoung-Tak Zhang. "Genetic Mining of DNA Sequence Structures for Effective Classification of the Risk Types of Human Papillomavirus (HPV)." In Neural Information Processing, 1334–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-30499-9_208.

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Mahoukèdè Zohoncon, Théodora, Rogomenoma Alice Ouedraogo, Florencia Wendkuuni Djigma, Lassina Traore, Teega-Wendé Clarisse Ouedraogo, Maimouna Ilboudo, Regine Ilboudo, et al. "Molecular Epidemiology of High-Risk Human Papillomavirus Infection in Burkina Faso." In Papillomaviridae Infections and Related Cancers - The Neo Challenges and Next Gen Solutions [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102327.

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The aim of the present study was to determine the distribution of high-risk human papillomavirus (HR-HPV) genotypes in childbearing age women, teenage girls, HIV-infected women, women with high-grade precancerous lesions and cervical cancer, sex workers, men, and otolaryngology tumor cases in Burkina Faso. This descriptive cross-sectional study with several target groups, consisted of 2386 samples from Burkina Faso. HR-HPV genotypes were characterized using real-time multiplex PCR. The prevalence of HR-HPV ranged from 15.63 to 72.31% depending on the target population and the nature of the samples. The most predominant genotypes in descending order were HPV-56, HPV-52, HPV-39, HPV-59, HPV-51, HPV-35, HPV-31, HPV-18, HPV-68, HPV-16, HPV-66, HPV-58, HPV-45, and HPV-33. The results of the present study show a wide variation in the distribution of HR-HPV genotypes in Burkina Faso. Genotypes 16 and 18 covered by HPV vaccines only accounted for 32.23% of HR-HPV cases.

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Chung, Christine H., Andreas Dietz, Vincent Gregoire, Marco Guzzo, Marc Hamoir, René Leemans, Jean-Louis Lefebvre, et al. "Head and neck cancer." In Oxford Textbook of Oncology, 329–64. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199656103.003.0035.

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This chapter discusses head and neck cancers, and covers the epidemiology and molecular biology of head and neck cancer. Head and neck cancer is a heterogeneous disease and most commonly caused by tobacco and alcohol use, as well as high-risk human papillomavirus (HPV) infection. HPV-negative and -positive HNSCC are demographically, biologically and clinically distinct entities with more favourable outcomes associated with HPV-positive tumours of the oropharynx. Comprehensive genomic analyses show that more functional loss of tumour suppressors are present in HPV-negative tumours compared to HPV-positive tumours. Furthermore, HNSCC can be molecularly characterized into five subtypes. The challenges facing future investigations are efficient translation of these biological findings into clinically meaningful advancements in patient treatment.

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Vadaparampil, Susan T., Lindsay N. Fuzzell, Shannon M. Christy, Monica L. Kasting, Julie Rathwell, and Anna E. Coghill. "Viral Cancers and Behavior." In Psycho-Oncology, edited by Paul B. Jacobsen, 43–50. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780190097653.003.0007.

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One in every six cancers globally can be attributed to an infection. Human papillomavirus (HPV), hepatitis B virus (HBV), and hepatitis C virus (HCV) play a role in the development of over 1.2 million new cancers each year and are responsible for nearly 50% of the infectious cancer burden in the United States. Virus-attributable cancers occur more frequently in those living with human immunodeficiency virus (HIV). The chapter reviews high-risk lifestyle behaviors, including high number of lifetime sexual partners and injection drug use, that increase the risk of acquiring HPV, HBV, HCV, and HIV. It reviews prevention and control strategies for these viruses and associated cancers, including lifestyle behaviors, vaccination, screening, and/or appropriate use of antiretroviral medications.

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Hilfrich, Ralf. "HPV L1 Detection as a Prognostic Marker for Management of HPV High Risk Positive Abnormal Pap Smears." In Human Papillomavirus and Related Diseases From Bench to Bedside A Diagnostic and Preventive Perspective. InTech, 2013. http://dx.doi.org/10.5772/55902.

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Mills, Jacqueline M., and Elizabeth A. Stier. "Human Papillomavirus Infection of the Cervix." In 50 Studies Every Obstetrician-Gynecologist Should Know, 170–74. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780190947088.003.0031.

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In 1992 Lorincz et al. were the first to evaluate the clinicopathologic correlation with 11 recently identified human papillomavirus (HPV) genotypes: 31, 33, 35, 42, 43, 44, 45, 51, 52, 56, and 58. Using cervical samples from 8 studies that included specimens from 2627 women, HPV genotypes were categorized by the likelihood of association with grades of cervical neoplasia (from normal to cancer). These findings were the basis of the determination that (a) HPV causes cervical cancer, (b) detection of the cancer associated HPV genotypes could identify women at risk for cervical pre-cancer and cancer, and (c) a prophylactic HPV vaccine should include protection against (at least) HPV 16 and 18.

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Тези доповідей конференцій з теми "HR-HPV (High-Risk Human Papillomavirus)"

Wichmann, G., G. Loermann, M. Kolb, S. Fest, A. Dietz, and S. Wiegand. "High-risk Human Papillomavirus (HR-HPV) DNA Detection in Mouth Rinses for Diagnosis of HPV-driven oropharynx cancer." In Abstract- und Posterband – 91. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Welche Qualität macht den Unterschied. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1711012.

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Torre, Francesco La, Federica Barsanti, Irene Renda, Alessia Salamina, Francesca de Bonis, Isabella Abati, Francesco Magni, Flavia Sorbi, and Massimiliano Fambrini. "2022-RA-984-ESGO High-Risk Human Papillomavirus (HR-HPV) viral load: a new approach for high-grade Cervical Intraepithelial Neoplasia (CIN) treatment?" In ESGO 2022 Congress. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/ijgc-2022-esgo.78.

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Farzaneh, F., F. Jamdar, F. Navidpour, S. Yunesi, P. Balvayeh, M. Hosseini, and R. Robabeh Ghodssi-Ghasemabadi. "EP1074 Prevalence of high risk human papillomavirus infection among Iranian women using COBAS HPV DNA testing." In ESGO Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-esgo.1116.

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Gupta, Ishita, Ayesha Jabeen, Maria K. Smatti, Hamda A. Al-Thawadi, Gheyath K. Nasrallah, Ali A. Sultan, Moussa Al-Khalaf, Semir Vranic, and Ala-Eddin Al-Moustafa. "Co-Prevalence of Human Papillomavirus and Epstein Barr Virus in Healthy Blood Donors in Qatar." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0120.

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Introduction: Infections with human oncoviruses such as high-risk human papillomaviruses (HPVs) and Epstein-Barr virus (EBV) are globally prevalent in the adult population. Both viruses are strongly associated with several types of human carcinomas such as cervical, head and neck, nasopharyngeal and gastric. In the present study, we explored the prevalence of these two oncoviruses in the healthy population of Qatar. Methods: The study included 385 healthy blood donors that reflect diverse nationalities in the Qatari community (Qatar, Egypt, Syria, Jordan, Pakistan, and India). DNA was extracted from the peripheral blood and genotyping was done using PCR and nested-PCR targeting E6 and E7 as well as LMP1 genes of HPVs and EBV, respectively. Results: The age of participants (378 males and 7 females) ranged between 19 and 68 years (mean 37.12 ± 9.3 years). Our data indicate that 55% and 61% of the tested samples were HPVs and EBV positive, respectively. Moreover, we found that there was (40%) co-presence of both HPVs and EBV in our samples. The most common high-risk HPV types in Qatar included HPV 59 (55%), 31 (54%), 52 (49%), 51 (49%), 58 (47%) and 35 (46%). While, HPV 16 and 18 were detected in 38% and 36% of the samples, respectively. Notably, all samples showed multiple HPVs infections. Conclusion: Our study reveals for the first time a high prevalence of both EBV and HPVs among healthy individuals in Qatar. More significantly, most cases had multiple HPV types infection in addition to the co-presence of both viruses in a substantial proportion of the samples. Given the important possible cooperative role of these viruses in human carcinogenesis, preventive measures using available and upcoming vaccines are of paramount importance.

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Rocha, Willker Menezes da, Camila Freze Baez, Larissa Alves Afonso, Fernanda Nahoum Carestiato, Marianna Tavares Venceslau Gonçalves, Rafael Brandão Varella, and Silvia Maria Baeta Cavalcanti. "The use of DNA microarray assay as a diagnostic tool to study penile cancer associated with human papillomavirus." In XIII Congresso da Sociedade Brasileira de DST - IX Congresso Brasileiro de AIDS - IV Congresso Latino Americano de IST/HIV/AIDS. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/dst-2177-8264-202133p159.

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Introduction: The genital infection by the human papillomavirus (HPV) can result in a sexually transmitted disease associated with precursor lesions for carcinogenesis in the genital tract. In recent years, evidence was accumulated defining HPV as the etiologic agent of cervical cancer; however, the etiology of penile cancer is still open and lacks studies. This study aims to contribute to the epidemiologic knowledge regarding the prevalence of this virus in malignant lesions of the male genital tract, using the DNA microarray assay, a technique that allows the simultaneous detection of up to 32 different HPV genotypes. Objective: The aim of this study was to investigate the presence of HPV in penile malignant lesions, to genotype HPV, when present, to correlate the HPV infection and its genotypes with the histopathological data. Methods: A total of 112 penile cancer samples was collected in a cross-sectional study. The detection methodology consisted of (1) detecting the presence of HPV DNA by the polymerase chain reaction (PCR) technique with generic primers, (2) genotyping the HPV using the DNA microarray assay, and (3) correlation of the histopathology, tumor invasiveness, and the dispersion of malignant cells by the lymph nodes with the presence of HPV. Results: The HPV prevalence was 57.1% (64). The most prevalent genotype was the HPV16 (32.8%), followed by HPV6 (23.4%); HPV18, HPV35, and HPV45 (12.5%); HPV31 (10.9%); and HPV70 (7.8%). Of the HPV-positive samples, 25% were mixed infections. Conclusion: The role of the HPV infection was significant within the multifactorial etiology of penile cancer. There was statistical significance between the lesion invasiveness and the presence of high-risk HPV infection. Thus, genotype surveillance can promote a better understanding of the role of HPV genotypes in male cancer development, and the DNA microarray assay proved to be an efficient tool for both the epidemiological study and the diagnostics of the HPV.

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Herman, B. "APPLICATIONS OF LASER OPTICAL MICROSCOPIC TECHNIQUES IN DECIPHERING DISEASE SPECIFIC MECHANISMS AND DIAGNOSIS." In Biomedical Optical Spectroscopy and Diagnostics. Washington, D.C.: Optica Publishing Group, 2006. http://dx.doi.org/10.1364/bosd.1996.ft5.

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Accumulating evidence strongly associates human papillomavirus infection with the development of cervical cancers. However, it has also become increasingly clear that HPV infections of the cervix span a wide clinical spectrum from benign lesions to precancerous lesions, with only a minority of infections resulting in invasive cancers, although the reasons for this are not clear. Longitudinal epidemiologic studies using cytologic methods to detect HPV infection have shown that the majority of women infected with HPV will regress spontaneously. In addition, age-stratified data for rates of HPV positivity from cross-sectional studies also suggest that many women clear the infection spontaneously. These results support the concept that many women may be only transiently infected with HPV during their life span and only in women with persistent HPV infection does cervical cancer progress. In addition to persistence of HPV infection, recent epidemiological studies indicate that the amount of high-risk HPV (viral load or HPV gene copy number) in cervicovaginal epithelial cells may be a risk factor for cervical cancer. Thus, a technique which could detect, genotype and quantitate HPV in smears of cervicovaginal epithelial cells would be of major import in assessment of patient clinical status as well as in epidemiological studies relating HPV infection to cervical cancer.

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Motaghi, M. "EP367 Prevalence of high-risk human papillomavirus by cobas 4800 HPV test and the pathologic findings in women with high risk HPV positive in mashhad (North-east of iran)." In ESGO Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-esgo.426.

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Kumar, Anoop, Inderjit Singh Yadav, Rupinder Sekhon, Dwaipayan Bharadwaj, and Mausumi Bharadwaj. "Identification of T- and B-cell epitopes in HPV-16 E7 gene isolated from cervical cancer patients." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685256.

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Introduction: In India, cervical cancer is the most common cancer among females. Persistence infection with high risk human papillomaviruses (HR-HPV) is an etiological agent for cervical cancer development, especially HPV-16 is found to be exclusively high in cervical cancer cases in Indian population. The continuous expression and transforming ability of HPV E7 helps in progression of cervical cancer and other HPV related disease, which make E7 as a suitable targets for the development of therapeutic vaccines. Objectives: Identification of T-& B-cell epitopes HPV-16 E7 gene isolated from in cervical cancer patients. Materials and Methods: A total of 80 cervical cancer tissue biopsies were collected and processed for DNA extraction, HPV diagnosis and genotyping. E7 gene of HPV-16 positive samples were amplified and sequenced. Epitopes in E7 gene sequence were predicted by online freely available tools. Results: In the present study we got 72 samples (90%) were positive for HPV and out of which 68 samples (94.4%) were positive for the HPV-16. HPV-16 positive samples were sequenced and translated. IEDB server was used for epitope analysis; 12 potent epitopes for the MHC-I alleles were identified in isolated E7 gene of HPV-16. The most potent epitopes were MHGDTPTLHEYM for HLA-C*07:01; LLMGTLGIVCPI for HLA-A*02:01 and MHGDTPTLHEYML for HLA-C*07:01; having percentile rank 0.2 for all three and antigencity score of 0.20011, 0.15358 and 0.10735, respectively. Conclusion: This is an effective strategy to design immuno-therapeutics and therapeutic vaccine against HPV using E7 as target. These findings will be helpful in the development of effective vaccine for particular geographical region.

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Feijão, Maria Clara Tomaz, Fernanda Pimentel Arraes Maia, Eduarda Sousa Machado, Emanuel Cintra Austregésilo Bezerra, and Luiz Gonzaga Porto Pinheiro. "DERMOSCOPY OF THE PAPILLA TO THE IDENTIFICATION OF HUMAN PAPILLOMAVIRUS SIGNS IN TEN BREAST CANCER PATIENTS COMPARED TO TEN CONTROLS WITHOUT BREAST COMPLAINTS." In XXIV Congresso Brasileiro de Mastologia. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s1023.

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Introduction: The etiologic role of human papillomavirus (HPV) in breast cancer has been investigated. It is inferred that HPV may be involved in breast carcinogenesis, although the effect-cause nexus has not yet been proved. To develop minimally invasive methods that would help identify the virus in the breast, dermoscopy of the mammary papilla arised. The use of the dermoscope aims to determine a pattern of HPV-infected nipples in women with breast cancer, contributing to establish the relation between HPV and breast cancer. If the presence of HPV in the nipple could be diagnosed, a significant step would be taken to identify women at risk of developing cancer. The possibility of a noninvasive method collaborating for the diagnosis of early breast cancer is extremely useful in daily care. Objectives: The aim of this study was to investigate the use of dermoscopy in the search for signs of HPV in the mammary papilla by comparing 10 cases (patients with breast cancer) and 10 controls (patients without breast cancer) and the possibility of a positive relationship between HPV infection and breast alterations. Methods: In all, 196 patients attended an appointment at the mastology department in a reference center for breast cancer. They were studied with a dermoscope in conjunction with a 2-mm puncture biopsy to obtain genetic material. DNA samples were extracted using the DNeasy Blood & Tissue Kit (Qiagen, Hilden, Germany), followed by PCR amplification for the conserved HPV E6-E7 region. Then, 20 patients were selected by HPV findings identified on the images, which were stored on the FotoFinder Hub platform. Results: In the pilot project, 10 cases and 10 controls were selected. These patients were submitted for a dermoscopy and puncture biopsy to evaluate the possibility of HPV infection. Of the 10 cases, 3 showed positive HPV typing test result and exhibited an invasive carcinoma of no special type. Of the 10 controls, 4 had a positive test. Although these four patients did not have cancer, they presented other benign alterations, such as fibroadenomatoid hyperplasia of the breast and granulomatous mastitis, which corroborates the hypothesis that HPV may cause replication of malignant and benign cells. Furthermore, the cases that tested positive for HPV showed on the dermoscopy images intriguing alterations, such as increased vascularization, pigmentation changes, exacerbation of the cobblestone pattern, crevice-shaped nipple opening, and inflammatory lesions that were not observed on the images of the patients that had a negative HPV test result. Conclusion: The dermoscopy of the papilla is able to find signs indicative of HPV presence. For that reason, the dermoscope can be a useful tool in risk stratification and early diagnosis of breast cancer, considering that HPV might be involved in breast cancer’s carcinogenesis and other benign alterations.

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Omone, Ogbolu Melvin, Marta Takacs, and Miklos Kozlovszky. "Statistical Hypothesis Testing of Patients‘ Risk-Score Assessment Test For Human Papillomavirus (HPV)." In 2020 IEEE 18th International Symposium on Intelligent Systems and Informatics (SISY). IEEE, 2020. http://dx.doi.org/10.1109/sisy50555.2020.9217101.

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Звіти організацій з теми "HR-HPV (High-Risk Human Papillomavirus)"

van de Sande, Anna, Malika Kengsakul, Margot Koeneman, Marta Jozwiak, Cornelis Gerestein, Arnold-Jan Kruse, Edith van Esch, et al. Imiquimod in cervical dysplasia: a review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0046.

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Review question / Objective: To determine the efficacy of topical imiquimod in treatment of high-grade CIN (defined as regression CIN 1 or less), and to determine the clearance rate of high-risk human papillomavirus (hr-HPV), compared to surgical treatment and placebo. Condition being studied: Women with an untreated, histologically proven, CIN2-3 lesion or women who were persistent high-risk HPV positive. Eligibility criteria: Studies that evaluated the efficacy of imiquimod treatment in intraepithelial lesions or malignancy of other organs, and studies published as conference abstract, narrative review, editorial, letter, or short communication were excluded.

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Li, Yanhui. Efficacy of non-invasive photodynamic therapy for female lower reproductive tract diseases associated with HPV infection: a comprehensive meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0092.

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Review question / Objective: The critical point of this study was to comprehensively evaluate the curative effect of Photodynamic therapy (PDT) in diseases of female lower reproductive tract associated with the human papillomavirus (HPV) infection. Condition being studied: Traditional clinical recommendations for treating diseases of the female lower reproductive tract include topical therapy with drugs, surgery, intravaginal radiation, carbon dioxide (CO2) laser, etc. Although medication is easy to administer, it has a high recurrence rate and adverse effects such as burning sensation, pain, and dyspareunia. The other traditional treatment method is usually invasive, repeated operation of vaginal perforation, scar, easy recurrence, fertility decline, and other shortcomings. At present, the treatment strategy for cervical squamous intraepithelial lesion, vaginal squamous intraepithelial lesion, condyloma acuminatum, and vulvar lichen sclerosis are to protect the normal organ structure and function as much as possible, reduce recurrence, prevent disease progression and carcinogenesis, and preserve female reproductive function.

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