Дисертації з теми "Host Immune Respose"
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Millhouse, Emma. "Microbial biofilm composition influences the host immune response." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6848/.
Повний текст джерелаTattermusch, Sonja. "The host immune response to HTLV-1 infection." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9916.
Повний текст джерелаVerma, Meghna. "Modeling Host Immune Responses in Infectious Diseases." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/96019.
Повний текст джерелаDoctor of Philosophy
Infectious diseases caused by bacteria, fungi, viruses and parasites have affected humans historically. Infectious diseases remain a major cause of premature death and a public health concern globally with increased mortality and significant economic burden. These infections can occur either via air, travel to at-risk places, direct person-to-person contact with an infected individual or through water or fecal route. Unvaccinated individuals, individuals with suppressed and compromised immune system such as that in HIV carriers are at higher risk of getting infectious diseases. In spite of significant advancements in infectious diseases research, the control and treatment of these diseases faces numerous challenges. The mucosal immune system plays a crucial role in safeguarding the body from harmful pathogens, while being exposed to the environment, mainly food antigens. To develop treatment options for infectious diseases, it is vital to understand the immune responses that occur during infection. In this work, we focus on gut immune system that acts like an ecosystem comprising of trillions of interacting cells and molecules, including membars of the microbiome. The goal of this dissertation is to develop computational models that can simulate host immune responses in two infectious diseases- i) Helicobacter pylori infection and ii) human immunodeficiency virus (HIV)-human papilloma virus (HPV) co-infection. Firstly, it reviews the various mathematical techniques and systems biology based methods. Second, it introduces a "hybrid" model that combines different mathematical and statistical approaches to study H. pylori infection. Third, it highlights the development of a novel HIV/HPV coinfection model and compares the results from a clinical trial study. Fourth, it discusses the challenges that can be encountered in adapting machine learning based computational technologies. Taken together, the work in this dissertation presents modeling approaches that could lead to the identification of host immune factors in infectious diseases in a predictive and more resourceful way.
Watret, Karen Christine. "Graft-versus-host reaction and the mucosal immune response." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/19395.
Повний текст джерелаPost, Frank A. "Mycobacterial strain diversity : impact on the host immune response." Doctoral thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/2717.
Повний текст джерелаRowland, Caroline A. "Characterisation of host immune responses to Burkholderia mallei." Thesis, Open University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439229.
Повний текст джерелаAnderson, J. J. "The immune response to respiratory syncytial virus in an animal model." Thesis, University of Newcastle Upon Tyne, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380769.
Повний текст джерелаSmith, A. L. "Immunity response to Eimeria vermiformis infection in the mouse." Thesis, University of Nottingham, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284111.
Повний текст джерелаParsa, Venkata Laxmi Kishore. "Molecular mechanisms of host cell response to Francisella infection." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1195584597.
Повний текст джерелаRingqvist, Emma. "Host-Pathogen Responses during Giardia infections." Doctoral thesis, Uppsala universitet, Mikrobiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108980.
Повний текст джерелаContreras, Garcia Irazú. "Modulation of the host innate immune response by «Leishmania» parasites." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95096.
Повний текст джерелаLe parasite Leishmania a su développer des mécanismes sophistiqués lui permettant de déjouer les réponses immunitaires des macrophages dans le but de survivre à l'intérieur de son hôte mammifère. Parmi ces mécanismes, notons l'activation rapide de phosphatases, qui inactiveront des protéines kinases et des facteurs de transcription, causant ainsi l'abrogation de la production d'oxyde nitrique, de même que l'induction de molécules immunosuppressives. Cette thèse doctorale discute de nouveaux mécanismes utilisés par le parasite afin de moduler la réponse immunitaire des macrophages et des cellules dendritiques. Dans le présent rapport, nous décrirons le rôle des MRPs (Myeloid Related Proteins) 8 et 14 lors de l'infection par Leishmania. Produites par les neutrophiles, les MRPs 8/14 ont la capacité d'induire l'activité microbicide des macrophages. Nos résultats montrent qu'une sensibilisation active pré-infection des macrophages avec les MRPs 8/14 induit leur activation. Par contre, lorsque l'infection à L.major est antérieure à la stimulation avec les MRPs, l'activation des macrophages est significativement réduite. Les études in vivo démontrent quant à elles que l'abrogation des MRPs a entraîné une augmentation de la charge parasitaire, alors que l'injection de MRPs recombinantes réduit la taille de la lésion, de même que la charge parasitaire. Un des principaux mécanismes qu'utilisent les parasites Leishmania, afin de déjouer la réponse immunitaire innée, est l'altération de facteurs de transcription. À l'aide de nos résultats, nous démontrons que l'activité d'AP-1 est abolie suite à l'infection par Leishmania, ceci concordant avec la dégradation au noyau des protomères d'AP-1. Il est d'ailleurs à souligner que c-Jun, le principal activateur d'AP-1, est dégradé et clivé par Leishmania à l'intérieur du noyau, et ce de façon GP63 dépendante. Malgré le fait que les macrophages sont considérés comme les cell
Yadev, Nishant. "Investigating the host innate immune response mechanisms to Candida albicans." Thesis, University of Sheffield, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.575466.
Повний текст джерелаThullen, Timothy D. "Analyzing the host immune response to pneumocystis utilizing two rat." Cincinnati, Ohio : University of Cincinnati, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=ucin1066676759.
Повний текст джерелаHicks, Daniel Jake. "Characterisation of the host immune response to European bat Lyssavirus infection." Thesis, Royal Veterinary College (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559029.
Повний текст джерелаKe, Qi. "Negative Regulation of Host Innate Immune Signaling and Response Pathways by Viral and Host Regulatory Factors." University of Toledo / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1470185159.
Повний текст джерелаHollingsworth, Rosalind C. "An investigation of host and viral factors which may influence the rate of progression and clinical outcome of hepatitis C virus infection." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363931.
Повний текст джерелаFors, Lisa. "Ecology and evolution in a host-parasitoid system : Host search, immune responses and parasitoid virulence." Doctoral thesis, Stockholms universitet, Institutionen för ekologi, miljö och botanik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-115243.
Повний текст джерелаAt the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: Manuscript. Paper 4: Manuscript.
Blanc, Mathieu. "Sterol biosynthesis pathway is part of the interferon host defence response." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5556.
Повний текст джерелаLee, Katherine Shi-Hui. "The host immune response to Streptococcus pneumoniae : bridging innate and adaptive immunity /." Download the dissertation in PDF, 2006. http://www.lrc.usuhs.mil/dissertations/pdf/lee2006.pdf.
Повний текст джерелаAuld, Stuart Kenneth John Robert. "Fitness consequences of cellular immunity : studies with Daphnia magna and its sterilizing bacterial parasite." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5779.
Повний текст джерелаSmyth, Robin. "Role of Protein Kinase R in the Immune Response to Tuberculosis." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/41842.
Повний текст джерелаMcLauchlan, P. E. "Host-parasite interactions : cellular immune responses and modulation by cyclosporin A." Thesis, University of Aberdeen, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.593084.
Повний текст джерелаOrtiz, Marty Rebecca Josefina. "Staphylococcus aureus virulence factors dictate host signaling pathways and immune responses." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/77299.
Повний текст джерелаPh. D.
Djomkam, Leopold Tientcheu. "Differences between host immune responses to `Mycobacterium tuberculosis' and 'Mycobacterium africanum'." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590516.
Повний текст джерелаLopes, Carolina Schultz. "Regulação do desenvolvimento e resposta imune de lagartas de Diatraea saccharalis (Fabricius) (Lepidoptera: Crambidae) por Cotesia flavipes (Cameron) (Hymenoptera: Braconidae)." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/11/11146/tde-16092008-161549/.
Повний текст джерелаCotesia flavipes (Cameron) (Hym., Braconidae), as other koinobionts, is capable of regulating the host development to produce an suitable host environment to sustain and promote its own larval development at the host expenses. Female-derived substances from the reproductive tract (ovarian proteins, venom, polydnavirus) are injected into the host, affecting the host immune response and other physiological processes aiming to regulate the host hormone levels, nutrition and behavior. Our goal was to evaluate the role of these substances on Diatraea saccharalis (F.) (Lepidoptera: Crambidae) growth and development, and how the parasitism affects the host immune response. All female-derived substances were collected after parasitoid dissection by collecting the venom reservoir or the ovaries (ovarian proteins and polydnavirus). Dissections were carried out in ice-cold buffer, collected tissues were processed accordingly and the desired substances injected immediately after collection. Venom and ovarian proteins+polydnavirus (PDV) were injected jointly and separated in 0-12 hold 6th instars of D. saccharalis. The effect of these substances on host development and growth was evaluated by measuring the host weight gain, larval and pupal survivorship and developmental time. The effects of the parasitism on the host immune response was evaluated either at the cellular level, by measuring the total hemocyte count and the encapsulation capacity, and at the biochemical level, by measuring the prophenoloxidase activity and nitric oxide levels at different stages of parasitoid development (0, 1, 3, 5, 7 and 9 days after parasitism). Parasitoid ovarian proteins and PDV alone or co-injected with the venom arrested the host larval development, while the venom by itself only affected the host metamorphosis process. The host immune response was also affected by C. flavipes at a time-dependent manner. The total hemocyte count dropped at day 3 of parasitism, while the host encapsulation capacity was reduced during parasitoid development. The host prophenoloxidase activity was also affected mainly towards the end of parasitoid larval development, while the nitric oxide at the first 24 h after parasitism.
Rehm, Kristina Roper Rachel. "The Poxvirus A35 Protein Promotes Virulence by Regulating the Host Adaptive Immune Response." [Greenville, N.C.] : East Carolina University, 2010. http://hdl.handle.net/10342/2696.
Повний текст джерелаKumar, Ramesh Kumar al Athi. "Association of angiogenesis with the host Th1/Th2 immune response in brain tumours." Thesis, University of Hull, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421208.
Повний текст джерелаJohnston, Claire. "Isolates of Trichuris muris : host immune response and characterisation of secreted parasite antigens." Thesis, University of Manchester, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508261.
Повний текст джерелаTeng, Ooiean, and 丁瑋嫣. "Identification of CLEC5A in modulating host immune response after influenza A virus infection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208615.
Повний текст джерелаpublished_or_final_version
Public Health
Doctoral
Doctor of Philosophy
Marsh, Elizabeth Kate. "Host-pathogen interactions in the innate immune response of the nematode Caenorhabditis elegans." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/1191/.
Повний текст джерелаBarker, Emily Mary. "Virus-host interactions in the innate immune response to high-risk human papillomavirus." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610618.
Повний текст джерелаNicholls, Philip Keith. "The viral life cycle and host immune response during canine oral papillomavirus infection." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624413.
Повний текст джерелаSurendran, Naveen. "Unraveling the host innate immune response to a respiratory model of Brucella abortus." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/77100.
Повний текст джерелаPh. D.
THULLEN, TIMOTHY DAVID. "ANALYZING THE HOST IMMUNE RESPONSE TO PNEUMOCYSTIS UTILIZING TWO RAT MODELS." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1066676759.
Повний текст джерелаPark, Myeongseon. "Dissecting the impact of macrophage migration inhibitory factor (MIF) on host immune response." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/97565.
Повний текст джерелаPHD
Almond, Mark. "The effect of obesity on the host innate immune response to influenza infection." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/47967.
Повний текст джерелаAkinlotan, Morenikeji D. "Within-host dynamics of Chlamydia trachomatis infection: Repeat infections and the immune response." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/119362/1/Morenikeji%20Akinlotan%20Thesis.pdf.
Повний текст джерелаCorrado, Alessia <1984>. "Staphylococcus aureus bones and joints infections: in vivo studies and host immune response." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6570/1/Corrado_Alessia_Ph.D_thesis.pdf.
Повний текст джерелаCorrado, Alessia <1984>. "Staphylococcus aureus bones and joints infections: in vivo studies and host immune response." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6570/.
Повний текст джерелаLee, Jinhwa. "Effects of PB1-F2 and PA-X on the pathogenicity of H1N1 influenza virus." Diss., Kansas State University, 2016. http://hdl.handle.net/2097/34617.
Повний текст джерелаDepartment of Diagnostic Medicine/Pathobiology
Wenjun Ma
Influenza A virus (IAV) is a negative sense, single-stranded, segmented RNA virus with eight gene segments. It is an important respiratory pathogen which causes annual epidemics and occasional pandemics worldwide in humans and leads to considerable economic problems for the livestock industry. To control and prevent this significant disease, understanding the pathogenesis of IAVs is critical. Although some molecular mechanisms regarding virulence have been determined, IAV pathogenesis is not completely understood and is difficult to predict. The eight viral gene segments of IAV were thought to encode for 10 viral proteins. Since 2001, eight additional viral proteins have been identified, including PB1-F2, PB1-N40, PA-X, NS3, PA-N155, PA-N182, M42, and PB2-S1. However, the functions of these novel proteins in influenza virus replication as well as pathogenesis have not been fully elucidated. Although PB1-F2 protein is an important virulence factor of IAV, the effects of this protein on viral pathogenicity of swine influenza virus (SIV) remain unclear. In Chapter 2, we investigated the contribution of the PB1-F2 protein to viral pathogenicity of a virulent triple-reassortant (TR) H1N1 SIV in different hosts, pigs and mice. Our data indicate that PB1-F2 expression in virulent TR H1N1 SIV modulates virus replication and pathogenicity in the natural host, pigs, but not in mice. In addition, single amino acid (aa) substitution at position 66 (N/S) in the PB1-F2 has a critical role in virulence in mice but no effect was found in pigs. A novel IAV protein, PA-X consists of the N-terminal 191aa of PA protein and a unique C-terminal 41 (truncated form) or 61 (full-length form) aa residues encoded by +1 ribosomal frameshifting. Although several studies have demonstrated the PA-X protein as an important immune modulator and virulence factor, the impact of different expressions of PA-X protein including full-length, truncated or PA-X deficient forms on viral pathogenicity and host response remains unclear. In Chapter 3, we showed that expression of either truncated or full-length PA-X protein in 2009 human pandemic H1N1 (pH1N1) viruses suppresses host antiviral response by host shutoff activity which promotes viral growth and virulence in mice when compared to loss of PA-X expression. Furthermore, full-length PA-X expression displayed stronger impact on viral pathogenicity and host immune response compared to truncated PA-X expression. Taken together, our results provide new insights into the impact of PB1-F2 and PA-X proteins on virus replication, pathogenicity and modulation of host immune responses. This knowledge is important for better understanding of IAV pathogenesis.
Coon, Courtney A. c. "Host-Parasite Interactions in an Invasive Songbird." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5004.
Повний текст джерелаYin, Han. "MOLECULAR ANALYSIS OF HTLV-2 APH-2 IN VIRAL TRANSFORMATION, PERSISTENCE AND HOST IMMUNE RESPONSE." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1322156034.
Повний текст джерелаCaller, Laura Grace. "An investigation into BK Polyomavirus and host-virus interactions." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/288073.
Повний текст джерелаWelschinger, Robert. "Role of host response to hepadnavirus sAg in immunity and recovery." Thesis, The University of Sydney, 2004. https://hdl.handle.net/2123/27987.
Повний текст джерелаAnderson, Sarah M. "The Fatty Acid Oleate in the C. elegans Innate Immune Response." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1133.
Повний текст джерелаHendry, Julie. "The host immune and inflammatory response to Burkholderia cepacia in adults with cystic fibrosis." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285320.
Повний текст джерелаKeeton, Roanne Shay. "The role of TNFRp55 and TNFRp75 in the host immune response to Mycobacterium tuberculosis." Doctoral thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/11889.
Повний текст джерелаIncludes bibliographical references (leaves 85-97).
Tumor necrosis factor alpha (TNFα) is critical for host protective immunity against Mycobacterium tuberculosis infection. TNFRp55 and TNFRp75 can both bind TNFα and conduct signaling, however the respective roles, in particular that of TNFRp75 in an M. tuberculosis aerosol inhalation infection was poorly defined. In this study the role of signaling through TNFRp55 and TNFRp75 was investigated using TNFR deficient mice in an aerosol inhalation M. tuberculosis infection model.
Thompson, Iain James. "Manipulation of antigen presenting cells to enhance host immune responses to bacterial infection." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/40916.
Повний текст джерелаLi, Huajing, and 李華菁. "Oral commensal/pathogenic bacteria-host cells crosstalk : immuno-inflammatory response, microenvironmental regulation and signaling mechanism." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208543.
Повний текст джерелаOlive, Andrew James. "Immunity to Chlamydia trachomatis and Host-Pathogen Interactions During Infection." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11263.
Повний текст джерела