Дисертації з теми "Homeolog"
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Juery, Caroline. "Expression et régulation épigénétique des gènes homéologues chez le blé tendre." Thesis, Université Clermont Auvergne (2017-2020), 2020. http://www.theses.fr/2020CLFAC037.
Повний текст джерелаWithin the plant kingdom, a lot of species are polyploids, meaning that they present two or more sub-genomes in the nucleus of their cells. Polyploidy confers genetic redundancy that offers a high potential of innovations and adaptations by relaxing natural selection on genic sequences. This allows faster sub and neo-functionalization of genes but also a loss of sequences that might be stochastic or not between the sub-genomes. Bread wheat is a recent polyploidy species that derived from two interspecific hybridizations that occurred 800 000 and 10 000 years ago. The genome of this species contains three sub-genomes: AABBDD and in theory three copies of each gene (1A:1B:1D). However, genomic analysis of the genome sequences reveals that half of the genes present copy number variations (NA:NB:ND). Within this scientific context, we wanted to answer questions such as: How this genetic redundancy evaluates after the polyploïdisation process? Is-it possible to observe differences in terms of gene expression that could correspond to functional evolution for this recently formed species? Which mechanisms could explain those processes? The objective of this PhD was to analyses relative expressions of homoeologous genes of bread wheat for groups presenting one copy on each sub-genomes (1 :1 :1, triades) and groups presenting a copy number variation with a loss (0:1:1, 1:0:1 ou 1:1:0), dyads or a duplication (2:1:1, 1:2:1 ou 1:1:2, tetrads) of sequences. We linked this analysis to genomic characteristics such as chromosome structure (genomic position of genes for exemple), evolution (presence or absence of lost and duplicated copies within diploid genomes of the progenitor species) and epigenetics (histone modifications). We used RNA-seq and ChIP-seq data released at the same time as the publication of the genomic reference sequence of bread wheat (IWGSC 2018). We highlight that the 51,1% of triads genes present mostly (81%) a balanced expression across the 15 tissues and developmental stages analyzed (high and constitutive expression) Those genes are mainly associated with the H3K9ac histone mark that is linked to an active transcription of genes. At the opposite, dyad genes (11,7% of High Confidence wheat genes) and tetrad genes (2,8%) present more frequently unbalanced expression patterns (36% and 74,5% respectively). Those genes are more associated with the histone mark H3K27me3 defining facultative heterochromatin and that target genes with transient expression. No dominance of one sub-genome on the others was discovered at the whole genome scale but rather stochastic suppression of genes copies. These results reveals potential sub-functionalization of genes, more frequent for copies present I the distal regions of chromosomes and associated with the epigenetic mark H3K27me3. Even if the homoeolog expression bias mostly corresponds to already existing divergence between diploid progenitor species, we nevertheless observe expression bias corresponding to the different step of bread wheat evolutive history: copies from sub-genome D are less repressed than the A or B copies; expression bias between AABB copies are more pronounced. In that respect the co-evolution of the two sub-genomes AABB during 800 000 years are traceable while D sub-genome seems to still present a nearly autonomous expression Combined together, these results suggest that wheat genome contains genes evolutionary constraints that correspond to a “core” genome of the species with basic conserved function (triad genes) and genes that present variation of the number of gene copies with differential regulations and specific functions that correspond to “dispensable” genes (dyads and tetrads)
Grier, D. G. "Homeobox genes in lung development." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426729.
Повний текст джерелаVoronina, Vera A. "Rx plays multiple roles in eye development." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2984.
Повний текст джерелаTitle from document title page. Document formatted into pages; contains viii, 123 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 94-123).
Quinn, M. F. "Homeobox gene expression in acute leukaemia." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398094.
Повний текст джерелаCarreiro, Lenn. "Characterization of the Alx3 homeobox gene." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0005/MQ40789.pdf.
Повний текст джерелаBokaee, Shadi. "Trageting homeobox genes for cancer immunotherapy." Thesis, University of Surrey, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543286.
Повний текст джерелаHui, Jerome Ho Lam. "The Evolution of clustered Homeobox genes." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490081.
Повний текст джерелаButts, Thomas. "The nevolution of animal homeobox genes." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543559.
Повний текст джерелаBaxter, Euan W. "Homeobox containing genes in the leech." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/19982.
Повний текст джерелаChen, Weizhong. "Homeobox genes and regeneration in asteroid echinoderms." Thesis, Royal Holloway, University of London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272109.
Повний текст джерелаO'Kernick, Christina M. "The identification of downstream effectors of the Rx gene and its proposed role in anophthalmia/microphthalmia." Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2390.
Повний текст джерелаTitle from document title page. Document formatted into pages; contains viii, 56 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 50-54).
Wood, Angela Clare. "Expression of the HOX A gene cluster in acute myeloid leukaemia." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300219.
Повний текст джерелаRemiszewski, Jacqueline Lee. "The role of Gbx2 in murine embryonic development : a thesis submitted to the University of Adelaide for the degree of Doctor of Philosophy /." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phr388.pdf.
Повний текст джерелаJakt, Lars Martin. "Isolation of mouse Hoxb-3 protein binding sequences : a whole genome approach /." Thesis, Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21185505.
Повний текст джерелаWang, Ming Hsiu. "Molecular evolutionary analysis of TALE homeobox in Viridiplantae." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52898.
Повний текст джерелаScience, Faculty of
Botany, Department of
Graduate
Kulak, Stephen. "Mutational analysis of the homeobox transcription factor PITX2." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0021/MQ47053.pdf.
Повний текст джерелаBooth, Hilda Anne Foreman. "The diversity of human homeobox genes and pseudogenes." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441051.
Повний текст джерелаPopov, Nikolay Radomirov. "Regulation of senescence by the homeobox protein HLX1." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529363.
Повний текст джерелаStickland, Julia Elizabeth. "Analysis of homeobox-containing genes in Xenopus borealis." Thesis, University of Leeds, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236401.
Повний текст джерелаLuke, Graham Nigel. "The NK homeobox gene cluster of Branchiostoma floridae." Thesis, University of Reading, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408097.
Повний текст джерелаHirako, Mayu. "Homeobox gene expression in normal haemopoiesis and leukaemogenesis." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407882.
Повний текст джерелаGorski, David Henry. "Homeobox gene expression and regulation in vascular myocytes." Case Western Reserve University School of Graduate Studies / OhioLINK, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=case1057944521.
Повний текст джерелаSilva, Silvokleio da Costa. "Homeologia e evolução dos cromossomos marcadores dos citros." Universidade Federal de Pernambuco, 2012. https://repositorio.ufpe.br/handle/123456789/12749.
Повний текст джерелаMade available in DSpace on 2015-04-08T14:28:46Z (GMT). No. of bitstreams: 2 TESE_PPGCB_CCB_UFPE_Silvokleio da Costa Silva.pdf: 2416257 bytes, checksum: 816b850e0c404efe1ff888b803d05780 (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Previous issue date: 2012
CNPq
Recentemente, um mapa citogenético estabelecido para Poncirus trifoliata disponibilizou marcadores cromossomo-específicos para estudos evolutivos das espécies cítricas. Objetivando reconhecer as homeologias cromossômicas e entender as alterações cariotípicas existente entre os gêneros Poncirus e Citrus e entre os principais representantes dos citros, os mapas citogenéticos de P. trifoliata cv. Flying Dragon, C. reticulata cv. Cravo (tangerina) e C. maxima cv. Pink (toranja) foram construídos e comparados entre si e com o mapa previamente estabelecido para C. medica var. Etrog (cidra). Os cromossomos marcadores de P. trifoliata também foram mapeados em C. sinensis (L.) cv. Valencia (laranjeira doce), o principal híbrido de interesse econômico do grupo. Metáfases mitóticas destas espécies foram coradas com os fluorocromos CMA e DAPI e submetidas a hibridização in situ fluorescente (FISH) empregando sondas de cromossomos artificiais de bactérias (BACs) e de DNAr 5S e 45S. As fórmulas cariotípicas encontradas para as cultivares analisadas de P. trifoliata (4B+8D+6F), C. reticulata (2C+10D+6F), C. maxima (4A+2C+4D+8F) e C. sinensis (2B+2C+7D+7F) corroboram com as anteriormente reportadas na literatura, entretanto, um pequeno sítio proximal adicional de DNAr 45S foi detectado em C. reticulata. Apenas os cromossomos 1, 4 e 8 foram conservados quanto ao tipo cromossômico e localização dos BACs entre as espécies estudadas. Nos demais casos, as posições dos BACs foram conservadas, mas não os tipos cromossômicos. Quebra de colinearidade foi observada apenas no par 3, entre BACs e um sítio de DNAr 45S, sugerindo que inversões ou transposições também podem ter ocorrido. Os resultados aqui reportados indicam uma alta sintenia no grupo. As principais divergências cariotípicas observadas provavelmente estão relacionadas a eventos de amplificação e/ou desamplificação de sequências repetitivas que compõem os blocos CMA+. Essas alterações foram mais frequentes em C. medica que nas demais espécies, porém, considerando a variabilidade encontrada, as semelhanças cariotípicas observadas entre espécies filogeneticamente distantes podem ser fruto de reversões e não da conservação de um cariótipo ancestral. Os dados de mapeamento dos BACs nos pares cromossômicos 2 e 3 de C. sinensis, associados aos seus tipos cromossômicos, corroboram toranja e tangerina como os prováveis parentais deste híbrido.
Thomas, Paul Quinton. "Homeobox gene expression in murine embryonic stem cells." Title page, contents and summary only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09pht4608.pdf.
Повний текст джерелаShah, Supriya A. "Determination of Rx expression in the adult mouse retina and delineation of the Rx mediated gene regulation." Morgantown, W. Va. : [West Virginia University Libraries], 2005. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4080.
Повний текст джерелаTitle from document title page. Document formatted into pages; contains viii, 99 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 82-99).
Chan, Chun-leung Sherwin, and 陳俊良. "Expression profiling and epigenetic regulation of Hox genes in cellular models of chondrogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44515534.
Повний текст джерелаNatarajan, Dipa. "Design and use of Hox-2 gene targeting constructs in murine embryonic stem cells." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240072.
Повний текст джерелаWong, Shuk-ying Esther. "NANOG in ovarian cancer." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42925058.
Повний текст джерелаValerius, Michael Todd. "Downstream effectors of the homeobox transcription factor Hoxa 11." Cincinnati, Ohio : University of Cincinnati, 2004. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1078859617.
Повний текст джерелаTitle from electronic thesis title page (viewed July 14, 2006). Includes abstract. Keywords: homeobox; vertebrate; microarray; development. Includes bibliographical references.
Jerevall, Piiha-Lotta. "Homeobox B13 in breast cancer : Prediction of tamoxifen benefit." Doctoral thesis, Linköpings universitet, Onkologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-68137.
Повний текст джерелаThorsteinsdottir, Unnur. "Functional analysis of selected Hox homeobox genes in hematopoiesis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq25175.pdf.
Повний текст джерелаLooser, Jens. "Identification of two novel CVC domain-containing homeobox genes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1995. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ45845.pdf.
Повний текст джерелаLincoln, Joy. "Developmental studies of the murine homeobox gene, Hoxa-9." Thesis, Durham University, 2002. http://etheses.dur.ac.uk/4145/.
Повний текст джерелаLeong, Fong Tat Eugene. "Hop : an unusual homeobox gene involved in heart development." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438484.
Повний текст джерелаRoccaro, Mario. "Leaf-shape mutants and homeobox genes in Antirrhinum majus." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/11325.
Повний текст джерелаPatel, Ruchi. "The role of homeobox gene NKX3.1 in prostate cancer." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:ca3d2321-3296-4c61-a5fb-57f1d99f9bb1.
Повний текст джерелаPfeffer, Peter Lance. "The isolation and characterization of a P. Angulosus homeobox." Doctoral thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/21983.
Повний текст джерелаThe aim of this thesis was to isolate and characterize a homeobox-containing gene of the South African sea urchin Parechinus angulosus. This was achieved by constructing a genomic library of several individuals and screening this library using a probe containing the Antennapedia homeobox. Eight clones were isolated and shown to represent different alleles of the same gene. One clone was sequenced, revealing a homeobox which was termed PaHboxl. This homeobox was compared to published homeobox sequences and shown to be a member of the Antp (Hoxl.l) subclass (table 1.1). A splice donor site was identified 23 bp upstream of the homeobox and the observation confirmed by RNAase mapping. PaHboxl is situated in a genomic area showing a significantly higher degree of restriction fragment polymorphism than expected. This was shown by a statistical analysis which should be of general value in the interpretation of such polymorphisms. The expression of PaHboxl was examined by RNAase protection assays and Northern blotting. Two distinct phases of expression were observed - during embryogenesis PaHboxl is expressed transiently at low levels in 11,5 hr mesenchyme blastula stage embryos (44 ± 8 transcripts per embryo) with levels 3-5 fold lower 2,5 hr before and after this stage. Expression is observed again at up to 160 fold higher levels in the adult with maximal expression in testis (11 transcripts per 10 pg total RNA), and increasingly lower levels in intestines, ovary and Aristotle's lantern. Two transcripts of size 5,2 and 5,7 kbp were observed. Expression in Aristotle's lantern and embryonic stages could not be detected by Northern analysis.
Mui, Stina Hung. "Ventral anterior homeobox (Vax) Genes in vertebrate eye development /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2002. http://wwwlib.umi.com/cr/ucsd/fullcit?p3059904.
Повний текст джерелаLanning, David Allen. "Excisional Wound Healing and the Role of Homeobox Genes." VCU Scholars Compass, 2000. https://scholarscompass.vcu.edu/etd/5132.
Повний текст джерелаHeidari, Mansour. "Investigation of the molecular function of the nuclear oncoprotein HOX11 in human t-cell leukaemia." Thesis, Heidari, Mansour (2003) Investigation of the molecular function of the nuclear oncoprotein HOX11 in human t-cell leukaemia. PhD thesis, Murdoch University, 2003. https://researchrepository.murdoch.edu.au/id/eprint/71/.
Повний текст джерелаHeidari, Mansour. "Investigation of the molecular function of the nuclear oncoprotein HOX11 in human t-cell leukaemia." Murdoch University, 2003. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20060815.123509.
Повний текст джерелаZhou, Bo. "Structural studies of geminin-hox and smad-hox complexes /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?BICH%202007%20ZHOU.
Повний текст джерелаCheng, Wai-chun. "Studying Hoxb5 functions in enteric nervous system development by dominant-negative repressor engrailed-Hoxb5." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39634528.
Повний текст джерела凌錦榮 and Kam-wing Ling. "Study of transgenic mice ectopically expressing the mouse Hoxb-3 gene." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31238993.
Повний текст джерелаCheng, Wai-chun, and 鄭維俊. "Studying Hoxb5 functions in enteric nervous system development by dominant-negative repressor engrailed-Hoxb5." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39634528.
Повний текст джерелаWong, Shuk-ying Esther, and 黃淑瀛. "NANOG in ovarian cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42925058.
Повний текст джерелаPatterson, Kristin Diane. "Vertebrate tinman-related homeobox genes during heart and spleen development in Xenopus /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.
Повний текст джерелаNewman, Craig Stephen. "The characterization of developmentally regulated homeobox genes in the frog Xenopus laevis /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.
Повний текст джерелаLing, Kam-wing. "Study of transgenic mice ectopically expressing the mouse Hoxb-3 gene /." Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20735212.
Повний текст джерелаBibb, Lindsay Claire. "Molecular studies on the cone-rod homeobox (CRX) transcription factor." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404407.
Повний текст джерела