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Автор: Grafiati
Опубліковано: 7 липня 2024

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1

Kalwaghe, Samidha N., and Atul Vasudev Dusane. "Hole Detection and Healing in Hybrid Wireless Sensor Network." APTIKOM Journal on Computer Science and Information Technologies 1, no. 2 (June 16, 2016): 41–45. http://dx.doi.org/10.34306/csit.v1i2.43.

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The emerging technology of wireless sensor network (WSN) is expected to provide a broad range of applications, such as battlefield surveillance, environmental monitoring, smart spaces and so on. The coverage problem is a fundamental issue in WSN, which may cause due to low residual energy of nodes or poor installment. But in order to get full coverage of sensing area Coverage problem must be avoided. If the problem is unavoidable the coverage hole must be healed. Current hole healing algorithms uses complicated hole detection strategies like TENT rule. This project seeks to address the problem of hole detection and healing in mobile WSNs by deploying mobile sensors in the network, which is called hybrid sensor network. An enhanced hole detection and healing method (MHEAL) is proposed. MHEAL is a distributed and localized algorithm that operates in two distinct phases. First, is Distributed Hole Detection (DHD) proposed to identify the boundary nodes and discover holes. Second, is hole healing which uses a virtual forces based hole healing approach where only the nodes located at an appropriate distance from the hole and the nodes having maximum energy will be involved in the healing process. Unlike existing algorithms, proposed algorithm uses QURD based node detection and energy efficient Hole healing and thus solves the problem of hole with 100% coverage, minimum node movements and minimum node distance travelled thus giving a cost efficient solution.
2

Kalwaghe, Samidha N., and Atul V. Dusane. "Hole Detection and Healing in Hybrid Wireless Sensor Network." APTIKOM Journal on Computer Science and Information Technologies 1, no. 2 (July 1, 2016): 41–45. http://dx.doi.org/10.11591/aptikom.j.csit.105.

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The emerging technology of wireless sensor network (WSN) is expected to provide a broad range of applications, such as battlefield surveillance, environmental monitoring, smart spaces and so on. The coverage problem is a fundamental issue in WSN, which may cause due to low residual energy of nodes or poor installment. But in order to get full coverage of sensing area Coverage problem must be avoided. If the problem is unavoidable the coverage hole must be healed. Current hole healing algorithms uses complicated hole detection strategies like TENT rule. This project seeks to address the problem of hole detection and healing in mobile WSNs by deploying mobile sensors in the network, which is called hybrid sensor network. An enhanced hole detection and healing method (MHEAL) is proposed. MHEAL is a distributed and localized algorithm that operates in two distinct phases. First, is Distributed Hole Detection (DHD) proposed to identify the boundary nodes and discover holes. Second, is hole healing which uses a virtual forces based hole healing approach where only the nodes located at an appropriate distance from the hole and the nodes having maximum energy will be involved in the healing process. Unlike existing algorithms, proposed algorithm uses QURD based node detection and energy efficient Hole healing and thus solves the problem of hole with 100% coverage, minimum node movements and minimum node distance travelled thus giving a cost efficient solution.
3

Lutfallah, Alhalabi, and Zenati Mazen. "The effect of bone morphogenetic proteins BMP in comparison with A Xenograft in the management of bone defects." Global Journal of Medical and Clinical Case Reports 10, no. 4 (November 8, 2023): 035–41. http://dx.doi.org/10.17352/2455-5282.000176.

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Background: The aim of this study is to compare the effect of Bone Morphogenetic Proteins (rhBMP), carried on a gelatin sponge scaffold in comparison with the Xenograft BioOss® in the management of bone defects. Case presentation: The case is a one-year-old rabbit that had 4 identical holes 5*5 mm within the femur bone, BMP2 was placed within the first hole with a gelatin sponge, and the second defect was left empty. A gelatin sponge was placed alone within the third hole, and a BioOss® graft was placed within the last defect. The radiographic evaluation was conducted (1 and 2) months after the surgical work, and the histological assessment was conducted two months after the surgical work. Results: The results of the radiographic evaluation found that healing the BMP2 hole was better than healing in the empty and the gelatin sponge group holes. There was no big difference between the healing in the holes filled with rhBMP2 with gelatin sponge and the healing in the holes filled with BioOss®. Conclusion: The use of a gelatin sponge impregnated with Bone Morphogenetic Proteins improves and accelerates the healing of bone defects and is comparable to the effectiveness of using a BioOss® graft.
4

Suresh, T., C. Anbuananth, and G. Prabakaran. "An Efficient Healing and Hole Detection in Mobile Wireless Sensor Network Based on Distributed and Localized Algorithms." Asian Journal of Computer Science and Technology 7, S1 (November 5, 2018): 33–37. http://dx.doi.org/10.51983/ajcst-2018.7.s1.1809.

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The emerging trends of wireless sensor network (WSN) are estimated to afford a wide range of applications, such as battlefield surveillance, environmental monitoring, and smart spaces and so on. The coverage problem is an essential concern in the WSN. In this paper seeks to address the problem of hole detection and healing in mobile WSNs. This paper discuss the main drawbacks of existing solutions and identify four key elements that are critical for ensuring effective coverage in mobile WSNs: (i) Identifying the boundary of Region of Interest, (ii) Finding the coverage holes and estimating their characteristics, (iii) Identifying the best target locations to relocate mobile nodes to repair holes, and (iv) Dispatching mobile nodes to the target locations while minimizing the moving and messaging cost. This paper proposes a lightweight and comprehensive solution called Holes detection and healing, that addresses all of the aforementioned aspects. HEAL is a distributed and localized algorithm that operates in two distinct phases. First, a collaborative mechanism, called Distributed Hole Detection (DHD), is proposed to identify the boundary nodes and discover holes. Second, this paper presents a virtual force- based hole healing algorithm. Unlike existing algorithms, HEAL algorithm relocates only the adequate nodes within the shortest times with the lowest cost. Simulation results shows that HEAL provide a cost-effective and an accurate solution.
5

Zhu, Xinlei, Jiaxing Wang, Jianan Li, Haoyu Chen, Bo Huang, and Hua Yan. "The Healing Process and Functional Recovery of Neuroretina after Idiopathic Macular Hole Surgery without Internal Limiting Membrane Reversal Tamponade." Journal of Ophthalmology 2020 (May 5, 2020): 1–7. http://dx.doi.org/10.1155/2020/2478943.

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Purpose. To investigate the healing process and functional recovery of neuroretina after idiopathic macular hole surgery, as well as analyzing the influencing factors. Methods. Thirty-six eyes of 31 patients with full-thickness idiopathic macular hole (IMH) were enrolled in this retrospective study. All of them were operated using 23-gauge or 25-gauge vitrectomy with inner limiting membrane peeling and air tamponade. Spectral-domain optical coherence tomography was performed before surgery and after surgery to observe the structural changes of neuroretina. Results. Twenty eyes (55.56%) had the macular hole closed at 3 to 5 days after surgery (closed group), beginning from the inner retina based on OCT. Holes of 16 eyes (44.44%) remained unclosed and progressed to larger holes at 13 to 15 days (t = −2.811, P=0.013) after surgery (unclosed group). Compared with the eyes in the closed group, the eyes in the unclosed group had significantly larger hole diameter (t = −2.882, P=0.007). Postoperative BCVA was significantly improved in the closed group (t = 2.573, P=0.019) and not improved in the unclosed group (t = 0.606, P=0.554) at the 6-month follow-up. Conclusion. Full-thickness IMHs could achieve anatomic closure 3 to 5 days after surgery with first-step inner retina tissue bridging. Otherwise, they were not able to achieve hole closure and opened to larger holes about 2 weeks postoperatively. Macular hole diameter was an important factor affecting the healing of the holes. The delayed restoration of fovea detachment and ellipsoid area deficiency were responsible for poor vision outcomes after surgery.
6

Zhang, Zhao, Zaixin Lu, Xianyue Li, Xiaohui Huang, and Ding-Zhu Du. "Online hole healing for sensor coverage." Journal of Global Optimization 75, no. 4 (September 7, 2019): 1111–31. http://dx.doi.org/10.1007/s10898-019-00827-5.

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7

A, Lee. "Visual Light Leak in High-Frequency Electromagnetic Radiation Hole: A Photon-Electron Theory for Living Tissue for Explaining Myopia." Open Access Journal of Ophthalmology 7, no. 1 (January 31, 2022): 1–7. http://dx.doi.org/10.23880/oajo-16000243.

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If the frequency of the photon exceeds the threshold, the photon has enough energy to strike the electron away and forms a hole in living tissue include the eye. Longer time of high-frequency electromagnetic radiation will cause more holes and a larger radius of holes. Some visual light leak through the hole and cannot be refracted on the macula, this is myopia symptom of blurred vision, shortening the distance of the eye and the object will include more visual light into cornea and lens, this is myopia another symptom of nearsightedness. The longer eye axis is caused by strike of high energy photon. Blue light and X-ray from screen are two kinds of high-frequency electromagnetic radiation which can shot hole in eye and cause myopia. Healing the shot hole can cure myopia.
8

Murali, R., and Dr R. Rajappan. "Design and Analysis of Interpretation for Orthopedic Plate with Titanium Alloy." International Journal for Research in Applied Science and Engineering Technology 10, no. 7 (July 31, 2022): 4127–33. http://dx.doi.org/10.22214/ijraset.2022.45955.

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Abstract: The bone is considered as a linear-elastic, isotropic, and homogeneous materials. Trauma is a major cause of death and disability in both developed and developing nations. The mainly consider interpretation of accident after healing orthopaedic surgery plate replacement material design, evaluation, machining and optimization can be consider in this project. In this project setup is simply replacement method for three models of healing plate of single hole, four holes and six holes plate design in Solid Works. Evaluation process used in 3D finite element methods for a fractured bone with three models of titanium alloy plates is analysed using ANSYS workbench.
9

Kong, Zhong Hua, Li Gang Wu, Chun Ya Tong, and Zai Fei Luo. "Calculation of Self-Healing Contract Resistance of Metallized Film." Applied Mechanics and Materials 615 (August 2014): 236–39. http://dx.doi.org/10.4028/www.scientific.net/amm.615.236.

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Abstract. Self-healing is an interesting property of metallized capacitors. contract resistance is importance to self healing. In the paper contract resistance is calculated with different diameters of hole and different thickness of metal layer. The larger is radius of hole, the less is contract resistance. The thicker is metal layer, the less is contract resistance.
10

Bottlang, Michael, Sunil S. Shetty, Connor Blankenau, Jennifer Wilk, Stanley Tsai, Daniel C. Fitzpatrick, Lawrence J. Marsh, and Steven M. Madey. "Advances in Dynamization of Plate Fixation to Promote Natural Bone Healing." Journal of Clinical Medicine 13, no. 10 (May 14, 2024): 2905. http://dx.doi.org/10.3390/jcm13102905.

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The controlled dynamization of fractures can promote natural fracture healing by callus formation, while overly rigid fixation can suppress healing. The advent of locked plating technology enabled new strategies for the controlled dynamization of fractures, such as far cortical locking (FCL) screws or active plates with elastically suspended screw holes. However, these strategies did not allow for the use of non-locking screws, which are typically used to reduce bone fragments to the plate. This study documents the first in vivo study on the healing of ovine tibia osteotomies stabilized with an advanced active plate (AAP). This AAP allowed plate application using any combination of locking and non-locking screws to support a wide range of plate application techniques. At week 9 post-surgery, tibiae were harvested and tested in torsion to failure to assess the healing strength. The five tibiae stabilized with an AAP regained 54% of their native strength and failed by spiral fracture through a screw hole, which did not involve the healed osteotomy. In comparison, tibiae stabilized with a standard locking plate recovered 17% of their strength and sustained failure through the osteotomy. These results further support the stimulatory effect of controlled motion on fracture healing. As such, the controlled dynamization of locked plating constructs may hold the potential to reduce healing complications and may shorten the time to return to function. Integrating controlled dynamization into fracture plates that support a standard fixation technique may facilitate the clinical adoption of dynamic plating.
11

Singh, Parmod, and Yaw-Chung Chen. "Sensing coverage hole identification and coverage hole healing methods for wireless sensor networks." Wireless Networks 26, no. 3 (June 24, 2019): 2223–39. http://dx.doi.org/10.1007/s11276-019-02067-7.

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12

Velasco, Cassandra, Christopher Dunn, Cassandra Sturdy, Vladislav Izda, Jake Martin, Alexander Rivas, Jeffrey McNaughton, and Matlock A. Jeffries. "Ear wound healing in MRL/MpJ mice is associated with gut microbiome composition and is transferable to non-healer mice via microbiome transplantation." PLOS ONE 16, no. 7 (July 20, 2021): e0248322. http://dx.doi.org/10.1371/journal.pone.0248322.

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Objective Adult elastic cartilage has limited repair capacity. MRL/MpJ (MRL) mice, by contrast, are capable of spontaneously healing ear punctures. This study was undertaken to characterize microbiome differences between healer and non-healer mice and to evaluate whether this healing phenotype can be transferred via gut microbiome transplantation. Methods We orally transplanted C57BL/6J (B6) mice with MRL/MpJ cecal contents at weaning and as adults (n = 57) and measured ear hole closure 4 weeks after a 2.0mm punch and compared to vehicle-transplanted MRL and B6 (n = 25) and B6-transplanted MRL (n = 20) mice. Sex effects, timing of transplant relative to earpunch, and transgenerational heritability were evaluated. In a subset (n = 58), cecal microbiomes were profiled by 16S sequencing and compared to ear hole closure. Microbial metagenomes were imputed using PICRUSt. Results Transplantation of B6 mice with MRL microbiota, either in weanlings or adults, improved ear hole closure. B6-vehicle mice healed ear hole punches poorly (0.25±0.03mm, mm ear hole healing 4 weeks after a 2mm ear hole punch [2.0mm—final ear hole size], mean±SEM), whereas MRL-vehicle mice healed well (1.4±0.1mm). MRL-transplanted B6 mice healed roughly three times as well as B6-vehicle mice, and half as well as MRL-vehicle mice (0.74±0.05mm, P = 6.9E-10 vs. B6-vehicle, P = 5.2E-12 vs. MRL-vehicle). Transplantation of MRL mice with B6 cecal material did not reduce MRL healing (B6-transplanted MRL 1.3±0.1 vs. MRL-vehicle 1.4±0.1, p = 0.36). Transplantation prior to ear punch was associated with the greatest ear hole closure. Offspring of transplanted mice healed significantly better than non-transplanted control mice (offspring:0.63±0.03mm, mean±SEM vs. B6-vehicle control:0.25±0.03mm, n = 39 offspring, P = 4.6E-11). Several microbiome clades were correlated with healing, including Firmicutes (R = 0.84, P = 8.0E-7), Lactobacillales (R = 0.65, P = 1.1E-3), and Verrucomicrobia (R = -0.80, P = 9.2E-6). Females of all groups tended to heal better than males (B6-vehicle P = 0.059, MRL-transplanted B6 P = 0.096, offspring of MRL-transplanted B6 P = 0.0038, B6-transplanted MRL P = 1.6E-6, MRL-vehicle P = 0.0031). Many clades characteristic of female mouse cecal microbiota vs. males were the same as clades characteristic of MRL and MRL-transplanted B6 mice vs. B6 controls, including including increases in Clostridia and reductions in Verrucomicrobia in female mice. Conclusion In this study, we found an association between the microbiome and tissue regeneration in MRL mice and demonstrate that this trait can be transferred to non-healer mice via microbiome transplantation. We identified several microbiome clades associated with healing.
13

Lin, Fu-Tian, Chu-Sing Yang, Tien-Wen Sung, and Bi-jar Lin. "Decentralized Mobile Sensor Navigation for Hole Healing Policy in Wireless Hybrid Sensor Networks." International Journal of Future Generation Communication and Networking 6, no. 6 (December 31, 2013): 143–50. http://dx.doi.org/10.14257/ijfgcn.2013.6.6.15.

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14

Zhuang, Yaoming, Chengdong Wu, Hao Wu, Hao Chu, Yuan Gao, and Li Li. "The Repair Strategy for Event Coverage Holes Based on Mobile Robots in Wireless Sensor and Robot Networks." Sensors 19, no. 22 (November 19, 2019): 5045. http://dx.doi.org/10.3390/s19225045.

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In the application of the wireless sensor and robot networks (WSRNs), there is an urgent need to accommodate flexible surveillance tasks in intricate surveillance scenarios. On the condition of flexible surveillance missions and demands, event coverage holes occur in the networks. The conventional network repair methods based on the geometric graph theory such as Voronoi diagram method are unable to meet the conditions of flexible surveillance tasks and severe multi-restraint scenarios. Mobile robots show obvious advantages in terms of adaptation capacity and mobility in hazardous and severe scenarios. First, we propose an event coverage hole healing model for multi-constrained scenarios. Then, we propose a joint event coverage hole repair algorithm (JECHR) on the basis of global repair and local repair to apply mobile robots to heal event coverage holes in WSRNs. Different from conventional healing methods, the proposed algorithm can heal event coverage holes efficaciously which are resulted from changing surveillance demands and scenarios. The JECHR algorithm can provide an optimal repair method, which is able to adapt different kinds of severe multi-constrained circumstances. Finally, a large number of repair simulation experiments verify the performance of the JECHR algorithm which can be adapted to a variety of intricate surveillance tasks and application scenarios.
15

Beuttel, Elisabeth, Nicole Bormann, Anne-Marie Pobloth, Georg Duda, and Britt Wildemann. "Impact of Gentamicin-Loaded Bone Graft on Defect Healing in a Sheep Model." Materials 12, no. 7 (April 4, 2019): 1116. http://dx.doi.org/10.3390/ma12071116.

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Infections of bone are severe complications, and an optimization of grafting material with antimicrobial drugs might be useful for prevention and treatment. This study aimed to investigate the influence of gentamicin-loaded bone graft on the healing of bone defects in a sheep model. Metaphyseal and diaphyseal drill hole defects (diameter: 6 mm, depth: 15 mm) were filled with graft or gentamicin-loaded graft (50 mg/g graft) or were left untreated. Analysis of regeneration after three and nine weeks, micro-computed tomography (μCT), and histology revealed a significant increase in bone formation in the drill hole defects, which began at the edges of the holes and grew over time into the defect center. The amount of graft decreased over time due to active resorption by osteoclasts, while osteoblasts formed new bone. No difference between the groups was seen after three weeks. After nine weeks, significantly less mineralized tissue was formed in the gentamicin-loaded graft group. Signs of inflammatory reactions were seen in all three groups. Even though the applied gentamicin concentration was based on the concentration of gentamicin mixed with cement, the healing process was impaired. When using local gentamicin, a dose-dependent, compromising effect on bone healing should be considered.
16

Kutsukake, Mayako, Harunobu Shibao, Keigo Uematsu, and Takema Fukatsu. "Scab formation and wound healing of plant tissue by soldier aphid." Proceedings of the Royal Society B: Biological Sciences 276, no. 1662 (February 25, 2009): 1555–63. http://dx.doi.org/10.1098/rspb.2008.1628.

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In the social aphid Nipponaphis monzeni , a unique gall-repairing behaviour has been known: when a hole is made on the gall, many soldier nymphs discharge body fluid on the breach, which promptly solidifies and plugs the hole. Here, we experimentally investigated the subsequent fate of repaired galls and their inhabitants. Irrespective of natural repair by soldier nymphs or artificial repair with adhesive, repaired galls survived significantly better than non-repaired galls. Within a month after repair, the plant tissue around the hole proliferated and sealed up the hole. Many soldier nymphs were localized at the hole area and extermination of inhabiting aphids by insecticides aborted the gall regeneration, indicating that the gall regeneration requires inhabiting aphids, wherein soldier nymphs are likely to play a major role. This study provides an unprecedented case of scab formation and wound healing, which occurs at an animal–plant interface: scab derived from insect body fluid promptly plugs damaged plant tissue and subsequently the insects actively stimulate regeneration of the plant tissue, whereby the compromised plant tissue recovers. We suggest that the novel system may have evolved in the aphid lineage through enhancement and recruitment of the pre-existing capabilities of haemolymph coagulation and gall formation.
17

Mumtaz Basheer, Raid, Harith Hazim Kaskos, and Ragheed Mumtaz Basheer. "The ability of different bone replacing materials to induce bone formation (Experimental Study)." Mustansiria Dental Journal 1, no. 2 (December 15, 2004): 132–38. http://dx.doi.org/10.32828/mdj.v1i2.1108.

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Many bone replacing materials had been used to manage the problem of large defect folowing oralsurgery, of these materials include hydroxyapatite, bone morphogenic protein, allograft. nI this experimental study a pastes of eggshel powders and calcium sulfate (callus) had been implanted ni holes created ni the mandible of the six dogs and compared with control holes that filled nothing The results were evaluated clinically, radiographically and histopathologically. Clinically at the 7 postoperative day showed that the hole that filled with the cgg shell completely healed and difficult ot distinguish from het adjacent normal bone. While the hole that filed with calcium sulfate also proved a good healing potential but at less degree from that of eggshell, whereas the control hole was clearly obvious. Radiographically Osteogenesis was assessed by the degree of opacities ni that seems ot be clear in the three holes, which made on the mandible (Control, and the treated groups). But seem to be complete opacity ni the two treated group, while the control group only seems to be little. Histopathologically The results showed heavy infiltration of active osteoblasts cells which appear as a sheet of primitive spindle shaped cells surrounding the eggshell materials with immature bone (osteoid) along ti In control hole no osteoblast cell is seen only fibrosis. The hole that filled with callus showed moderate bone activity with little amount of osteoblast cells when compared with egg shel.
18

Zhang, Yong Jun, Jing Tao Han, Jing Liu, and Lv Zhang. "In Situ Observation of the Micro-Hole Healing Process." Key Engineering Materials 274-276 (October 2004): 817–22. http://dx.doi.org/10.4028/www.scientific.net/kem.274-276.817.

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19

Mehta, Latesh, and Manik Gupta. "Review Over Hole Healing Techniques in Wireless Sensor Networks." International Journal of Ad hoc, Sensor & Ubiquitous Computing 7, no. 1 (February 28, 2016): 01–20. http://dx.doi.org/10.5121/ijasuc.2016.7101.

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20

Williams, Jack. "The Ozone Hole: A Story of Healing and Hope." Weatherwise 71, no. 1 (January 2, 2018): 12–17. http://dx.doi.org/10.1080/00431672.2018.1392813.

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21

Díaz-Bertrana, M. C., J. L. Puchol, A. Sánchez, J. Franch, and I. Durall. "Interlocking nail treatment of long-bone fractures in cats: 33 cases (1995–2004)." Veterinary and Comparative Orthopaedics and Traumatology 18, no. 03 (July 2005): 119–26. http://dx.doi.org/10.1055/s-0038-1632950.

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SummaryA retrospective study between 1995 and 2004 of fracture repair in cats (n=46) using interlocking nails (ILN) was made. Only the cases in which clinical and radiographic examination of bone healing were available are included. Five humeral and twenty eight femoral fractures were reviewed. Multiple-hole interlocking nails (MH-ILN) were used in 22 fractures, with the four-hole model (FH-ILN) in the remaining cases. In three of the cases, the FH-ILN was transformed to a three-hole model by cutting the nail between the two most distal holes. The average length of humeral ILN was 78.8 mm, and the femoral ILN was 97.2 mm. Static fixation was performed in 27 cases, with dynamic fixation in the remaining. The medullary canal filling was 100% in both radiographic views in 16 cases. Intra-operative complications were encountered in two cases. A total number of 76 screws were inserted, with 5.26% of them being malpositioned. Malunion, in a deformed femur, and partial unscrewing of one screw were the only radiographic complications observed at the time of follow-up. The clinical outcome, as well as fracture healing, were excellent in all of the cases. The results of this study indicate that the 4.0 and 5.0 mm MH-ILN and FH-ILN can be used to repair simple or comminuted humeral and femoral fractures in cats.
22

Bromer, Frederik Duch, Mikkel Bo Brent, Jesper Skovhus Thomsen, and Annemarie Brüel. "Drill-Hole Bone Defects in Animal Models of Bone Healing: Protocol for a Systematic Review." JMIR Research Protocols 11, no. 7 (July 18, 2022): e34887. http://dx.doi.org/10.2196/34887.

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Background Bone fractures are common conditions of the musculoskeletal system. Several animal models of bone fractures have been established to help elucidate the complex process of bone healing. In the last decades, drill-hole bone defects have emerged as a method to study bone healing. Animal models of drill-hole defects are easy to standardize and do not require external fixation of the bone. However, current studies of drill-hole bone defects lack detailed descriptions of techniques and interstudy standardization. Objective This systematic review aims to present a detailed description of the different methods used to induce drill-hole bone defects in long bones of laboratory animals and to provide a comprehensive overview of their methodology and potential for investigation of bone healing. Methods A systematic search of PubMed and Embase will be performed of abstracts containing variations of the following four keywords: “long bone,” “drill-hole,” “regeneration,” and “animal model.” Abstract screening and full-text screening will be performed independently by 2 reviewers, and data will be extracted to a predesigned extraction protocol. The primary outcome of the included studies is the technique used to create the drill-hole bone defect, and secondary outcomes are any measurements or analyses of bone defect and regeneration. A narrative synthesis will be used to present the primary outcome, while information on secondary outcomes will be displayed graphically. The study protocol follows the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-analysis Protocols) guidelines. Results Abstract and full-text screening is ongoing and is expected to be completed by October 2022. Data extraction will commence immediately after, and the manuscript is expected to be completed by December 2023. The systematic review will follow the PRISMA statement. Conclusions The strength of this systematic review is that it provides a comprehensive methodological overview of the different drill-hole methods and their advantages and disadvantages. This will assist researchers in choosing which model to use when studying different aspects of bone healing. Trial Registration International Prospective Register of Systematic Reviews CRD42020213076; https://tinyurl.com/bp56wdwe International Registered Report Identifier (IRRID) PRR1-10.2196/34887
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Alhalabi, Lutfallah, and mazen zenati. "Case Report: The effect of bone morphogenetic proteins (BMP) in comparison with a xenograft in the management of mandibular bone defects." F1000Research 13 (January 8, 2024): 20. http://dx.doi.org/10.12688/f1000research.143598.1.

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Background This study aims to compare the effect of Bone Morphogenetic Proteins (rhBMP), carried on a gelatin sponge scaffold in comparison with the Xenograft BioOss® in the management of mandibular bone defects. Case presentation The case is a 48-year-old woman who had 2 cysts in the mandibular bone, BMP2 was placed within the first hole with a gelatin sponge, and a BioOss® graft was placed within the second defect. The radiographic evaluation was conducted before and after surgery and 1, 3, and 6 months after the surgical work. Histological assessment was conducted after 6 months of the surgical work. Results The results of the radiographic evaluation found that there was no big difference between the healing in the holes filled with rhBMP2 with gelatin sponge and the healing in the holes filled with BioOss®. Conclusion The use of a gelatin sponge impregnated with Bone Morphogenetic Proteins improves and accelerates the healing of bone defects and is comparable to the effectiveness of using a BioOss® graft.
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Singh, Krishna Bhan, Manisha Dixit, Kapil Dev, Rakesh Maurya, and Divya Singh. "Formononetin, a methoxy isoflavone, enhances bone regeneration in a mouse model of cortical bone defect." British Journal of Nutrition 117, no. 11 (June 14, 2017): 1511–22. http://dx.doi.org/10.1017/s0007114517001556.

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AbstractThe bone regeneration and healing effect of formononetin was evaluated in a cortical bone defect model that predominantly heals by intramembranous ossification. For this study, female Balb/c mice were ovariectomised (OVx) and a drill-hole injury was generated in the midfemoral bones of all animals. Treatment with formononetin commenced the day after and continued for 21 d. Parathyroid hormone (PTH1–34) was used as a reference standard. Animals were killed at days 10 and 21. Femur bones were collected at the injury site for histomorphometry studies using microcomputed tomography (μCT) and confocal microscopy. RNA and protein were harvested from the region surrounding the drill-hole injury. For immunohistochemistry, 5 µm sections of decalcified femur bone adjoining the drill-hole site were cut.μCT analysis showed that formononetin promoted bone healing at days 10 and 21 and the healing effect observed was significantly better than in Ovx mice and equal to PTH treatment in many aspects. Formononetin also significantly enhanced bone regeneration as assessed by calcein-labelling studies. In addition, formononetin enhanced the expression of osteogenic markers at the injury site in a manner similar to PTH. Formononetin treatment also led to predominant runt-related transcription factor 2 and osteocalcin localisation at the injury site. These results support the potential of formononetin to be a bone-healing agent and are suggestive of its promising role in the fracture-repair process.
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WANG, LIZHEN, FENG ZHAO, JINGYUN HAN, CHAO WANG, and YUBO FAN. "BIOMECHANICAL STUDY ON PROXIMAL FEMORAL NAIL ANTIROTATION (PFNA) FOR INTERTROCHANTERIC FRACTURE." Journal of Mechanics in Medicine and Biology 12, no. 04 (September 2012): 1250075. http://dx.doi.org/10.1142/s0219519412005125.

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The proximal femoral nail antirotation device (PFNA) is a typical implant to the treatment of intertrochanteric fractures. However, re-fracture of the femur shaft after nailing are usually been reported. The purpose of this study was to investigate the biomechanical features in the healed proximal femur at different stages in the healing process. Stress and strain distributions, total strain energy density (SED) along the femur and PFNA were analyzed in walking and stair climbing. Results showed remarkable stress concentration occurred near the locking bolt hole with retained PFNA, decreased after PFNA removal. Stair climbing resulted in higher strain at the locking bolt hole than normal walking. The conclusion can be drawn that non-removal of PFNA after healing may result in high fractural risk near locking bolt on femoral shaft. Meanwhile, stair climbing should be avoided during healing.
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Bao, Min, Xianliu Wang, Huihua Yuan, Xiangxin Lou, Qinghua Zhao, and Yanzhong Zhang. "HAp incorporated ultrafine polymeric fibers with shape memory effect for potential use in bone screw hole healing." Journal of Materials Chemistry B 4, no. 31 (2016): 5308–20. http://dx.doi.org/10.1039/c6tb01305h.

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K Al-khafaji, Lobna. "Histological and Histomorphometric Evaluation of Socket Healing After Application of Epidermal Growth Factor with synthetic hydroxyapatite powder in Rats." Mustansiria Dental Journal 19, no. 1 (January 24, 2024): 154–62. http://dx.doi.org/10.32828/mdj.v19i1.1007.

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Background: One of the serious challenges in dental treatment is socket healing after tooth extraction. Various researchers have attempted to develop efficient therapies for healing and regenerating damaged tissues after extraction. Many tissue engineering technologies have been used now a day to enhance tissue healing. Aim: The present study was planned to evaluate the efficacy of epidermal growth factor with synthetic hydroxyapatite powder in socket healing. Methods: six-Thirty male rats were included in this study and their lower incisors teeth were subjected to extraction. Animals were divided into the following three groups according to socket treatment. (A) control, socket hole left to heal without any application, (B)application of hydroxyapatite powder (HAP) in the socket, (C) application of epidermal growth factor (EGF) with hydroxyapatite powder in the socket. Histological evaluation for bone formation, bone cell and inflammatory cell count with histomorphometry of bone trabeculae percentage had been done to all study groups and for three periods (5,14 &28 days). Results: Epidermal growth factor with hydroxyapatite group showed early bone formation, more bone cell count, and less inflammatory cell infiltration in comparison to the HAP group and control at periods (5,14&28 days) and with a statistically significant difference (p<0.05). Bone trabeculae percentage was recorded to be high in the HAP&EGF group that filled the socket hole at (14 ,28 days) intervals in comparison to hydroxyapatite and control group. Complete re-epithelialization was observed only in the EGF&HAP group. Conclusions: Both the HAP&EGF group and the hydroxyapatite group show bone formation and good socket healing, but the EGF&HAP group showed to be faster in filling of boney socket hole with complete epithelization than hydroxyapatite group, therefor using EGF with HAP is more efficient and suggested the material of choice used for socket healing.
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Zou, Yong Gang, Bo Wang, Xiao Feng Liu, and Bing Zhang. "Mechanism Research on Pelleting Process and Block Self-Healing of Mixture Recycled Plastics in Die-Plate." Applied Mechanics and Materials 768 (June 2015): 36–44. http://dx.doi.org/10.4028/www.scientific.net/amm.768.36.

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For many recycled plastics, materials with different rheological properties and melting points are usually mixed together, and can not be separated. For this situation, the block of die-plate holes can be regarded as an important factor that must be taken into consideration in pelleting process. This paper discusses pelleting process in die-plate and reasons of die hole’s blocking. Finite element simulation is calculated to analyze the relationship between operation factors of pelleting process and blocking situation of die holes. Furthermore, block self-healing is realized by changing the velocity of polymer-melt in die-hole.
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Zheng, Zhong, Marco A. Fontelos, Sangwoo Shin, Michael C. Dallaston, Dmitri Tseluiko, Serafim Kalliadasis, and Howard A. Stone. "Healing capillary films." Journal of Fluid Mechanics 838 (January 16, 2018): 404–34. http://dx.doi.org/10.1017/jfm.2017.777.

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Consider the dynamics of a healing film driven by surface tension, that is, the inward spreading process of a liquid film to fill a hole. The film is modelled using the lubrication (or thin-film) approximation, which results in a fourth-order nonlinear partial differential equation. We obtain a self-similar solution describing the early-time relaxation of an initial step-function condition and a family of self-similar solutions governing the finite-time healing. The similarity exponent of this family of solutions is not determined purely from scaling arguments; instead, the scaling exponent is a function of the finite thickness of the prewetting film, which we determine numerically. Thus, the solutions that govern the finite-time healing are self-similar solutions of the second kind. Laboratory experiments and time-dependent computations of the partial differential equation are also performed. We compare the self-similar profiles and exponents, obtained by matching the estimated prewetting film thickness, with both measurements in experiments and time-dependent computations near the healing time, and we observe good agreement in each case.
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Korobelnik, Jean-François, Daniele Hannouche, Nacera Belayachi, Michel Branger, Jean-Eric Guez, and Thanh Hoang-Xuan. "Autologous Platelet Concentrate as an Adjunct in Macular Hole Healing." Ophthalmology 103, no. 4 (April 1996): 590–94. http://dx.doi.org/10.1016/s0161-6420(96)30648-9.

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Khelil, Abdelkader, Rachid Beghdad, and Amar Khelloufi. "3HA: Hybrid Hole Healing Algorithm in a Wireless Sensor Networks." Wireless Personal Communications 112, no. 1 (January 18, 2020): 587–605. http://dx.doi.org/10.1007/s11277-020-07062-2.

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Chai, Jin-Chun, Kartika Sari, Shui-long Shen, and Yuanqiang Cai. "Predicting self-healing ratio of GCL with a damage hole." Geotextiles and Geomembranes 44, no. 5 (October 2016): 761–69. http://dx.doi.org/10.1016/j.geotexmem.2016.05.010.

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Sharma, Priyanka, and Rishi Pal Singh. "Coverage hole identification & healing in Wireless Underground Sensor Networks." Measurement: Sensors 24 (December 2022): 100540. http://dx.doi.org/10.1016/j.measen.2022.100540.

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Paez-Amieva, Yuliet, Jaime Carpena-Montesinos, and José Miguel Martín-Martínez. "Innovative Device and Procedure for In Situ Quantification of the Self-Healing Ability and Kinetics of Self-Healing of Polymeric Materials." Polymers 15, no. 9 (April 30, 2023): 2152. http://dx.doi.org/10.3390/polym15092152.

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A new device and procedure for the in situ quantification of the extent of the self-healing and the kinetics of self-healing of polymeric materials were proposed. The device consisted of flowing an inert gas below the sample placed in a hermetically closed chamber. When the sample was perforated/damaged, the gas passed through the hole made in the polymeric material and the gas flow rate declined as the self-healing was produced. Once the gas flow rate stopped, the self-healing was completed. The proposed method was simple, quick, and reproducible, and several in situ self-healing experiments at different temperatures could be performed in the same sample. As a proof of concept, the new device and method have been used for measuring the self-healing ability of different polyurethanes.
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Easley, Jeremiah, Christian Puttlitz, Cecily Broomfield, Ross Palmer, Alexander Jones, and Kirk C. McGilvray. "Biomechanical and Histological Assessment of a Polyethylene Terephthalate Screw Retention Technology in an Ovine Metatarsal Fracture Model." Veterinary and Comparative Orthopaedics and Traumatology 33, no. 03 (February 23, 2020): 153–60. http://dx.doi.org/10.1055/s-0039-3402518.

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Abstract Objective Screw loosening in fracture fixation poses a clinical risk which may lead to implant failure, particularly in poor bone quality. The objective of this study was to examine the effectiveness of a novel screw retention technology (SRT) for increased screw purchase in a large animal metatarsal fracture model. Study Design This was a biomechanical, radiographic, and histological study utilizing an ovine metatarsal fracture model. Twenty-four sheep metatarsi underwent 3-mm ostectomies and were repaired with a nine-hole plate and 3.5-mm screws placed in oversized 3.5-mm holes to simulate worst case revision surgeries (i.e. no initial screw thread bone contact). Sheep were sacrificed at 3, 6 or 12 weeks (n = 6 each) post-operation. Post-sacrifice, each surgically implanted screw underwent either destructive mechanical testing or histomorphometric analyses. Results Treated metatarsi showed improved screw retention and normal fracture healing. Significant improvement in breakout strength and pullout strength of screws treated with the SRT were found as a function of healing time. Histologically, bone ingrowth at the screw interface was also shown to significantly increase with healing time. Improvements in fracture healing, indicated by an increase in bone fraction and decrease in void space at the osteotomy, were also observed with healing time. Conclusion The results demonstrate the effectiveness of the SRT as a method for improved screw retention in a rescue-screw type scenario.
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Uzer, Gökçer, Nuh Mehmet Elmadağ, Fatih Yıldız, Yunus Güzel, and Olgu Enis Tok. "Increasing number of small hole diameter microfracture compared with traditional microfracture in same size cartilage defects and effect of HA based aselluler scaffold. An animal study." Orthopaedic Journal of Sports Medicine 5, no. 2_suppl2 (February 1, 2017): 2325967117S0008. http://dx.doi.org/10.1177/2325967117s00081.

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Purpose: The purpose of this study is small hole microfracure method comparing with traditional microfracture method and investigation of effect of HA based acellular matrix scaffold on microfracture area. Materials-Methods: 21 Twenty-one New Zealand white rabbits were used for the in vitro portion of this study, bilateral knee joint from the same rabbit were same technic. An articular cartilage defect was established in the femoral trochlear groove about 5 mm. Control group was established alone microfracture (MF). 6 groups were formed in this study and each group has 3 rabbits and their six knees. In 3 groups were applied different number of small diameter hole microfracture (4,5,6 small holes microfracture respectively)and the other 3 groups were applied different number of small diameter hole microfracture (4,5,6 small holes micro fracture respectively added HA based acellular matrix scaffold in the same size ostechondral lesion. The regenerated tissues were harvested for gross morphology, histology at 12 weeks postoperatively. Results: Cartilage were regenerated, maintaining a constant thickness of cartilage. MF group has worse Wakitani scores than 6 small diameter holes mıcrofracture groups(group 6 and group 7) in either parameter of the score. (p=0,043, p=0,016) Matrix addition did not contribute to healing. (p=1,000) Conclusions: Increasing number of the small diameter holes microfracture (minimum %15 of defect size) improves cartilage repair compared with traditional MF in the same size ostechondral lesion. Also small diameter holes microfracture combined with HA-based AM implantation didn’t result in improved quality of the regenerated cartilage tissue.
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Rwigema, Jean-Claude, Abhay Gokhale, Julie Glowacki, Tracy Dixon, Ken Patrene, G. David Roodman, Peter Wipf, and Joel Greenberger. "Impaired Osseous Wound Healing Following Ionizing Irradiation Is Ameliorated by Mitochondrial Targeted Nitroxide JP4-039." Blood 114, no. 22 (November 20, 2009): 4576. http://dx.doi.org/10.1182/blood.v114.22.4576.4576.

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Abstract Abstract 4576 In the case of a nuclear explosion, combined injuries may include ionizing irradiation and bone fracture. We evaluated the potential bone wound healing stimulation capacity of a new mitochondrial targeted nitroxide - JP4-039 - that was developed and demonstrated to protect against total body irradiation. JP4-039 was synthesized by coupling Tempol (4-hydroxy-2,2,6,6-tertamethylpiperidine-N-oxyl) and a novel alkene isotere analog of a gramicidin S (GS) fragment. JP4-039 is now being tested to determine whether it can also improve osseous wound healing. A model for osseous wound healing was used in the right hind leg of C57BL/6NHsd female mice and irradiated in doses ranging from 0 to 30 Gy, then holes drilled in both tibias 24 hr later. The mice were sacrificed at 7, 14, 21, 28 or 35 days. Tibial wounding and x-rays were used for determination of wound size. The bones were fixed, sectioned, and examined for osseous wound repair. A significant irradiation- induced delay in wound repair (hole diameter) was detected at 21 days in both the 20 Gy (0.93 ± 0.11 mm, p=0.008) and 30 Gy (1.1 ± 0.1 mm, p=0.0002) groups, compared with the 0 Gy group (0.67 ± 0.23 mm). At 28 days, there were statistically significant increased hole diameters between each irradiation groups (10 Gy, 0.76 ± 0.08 mm, p=0.003; 20 Gy, 0.87 ± 0.36 mm, p=0.04; 30 Gy, 0.76 ± 0.22 mm, p=0.02) and the 0 Gy group (0.32 ± 0.32 mm). By day 35, the wounds in the 0 Gy group were healed (0.08 ± 0.17 mm), while wounds in the 20 Gy group (0.22 ± 0.24 mm, p=0.02) and 30 Gy group (0.34 ± 0.23 mm, p=0.001) remained significantly larger. To determine whether JP4-039 improved the time of osseous wound healing, mice were injected intraperitoneally with JP4-039 (10 mg/kg) 10 min before drilling holes in both rear legs. Mice injected with JP4-039 before drilling showed significant improvement in osseous wound healing in 14 days and 21 days after drilling (0.55 ± 0.3 and 0.47 ± 0.04 mm, respectively), compared with 0.84 ± 0.05 and 0.64 ± 0.05 mm, respectively for control mice (p < 0.05 according to Tukey's multiple comparison statistical test). To test whether JP4-039 can improve osseous wound healing in irradiated limbs, mice were injected with JP4-039 (10 mg/kg) 10 min before 20 Gy to the right hind leg. Wounds were made in both tibae 24 hr after irradiation. At 21 and 28 days after wounding, bones from JP4-039 treated-irradiated mice displayed improved healing with holes of 0.51 ± 0.05 and 0.37 ± 0.04 mm, respectively, compared with 1.01 ± 0.10 and 0.76 ± 0.13 mm, respectively, for control irradiated bones. This is significant at < 0.05 as calculated using a Tukey's multiple comparison statistical test. Histopathological evaluation of specimens from mice pre-treated with JP4-039 prior to irradiation confirmed radiographic evidence of improved healing. Thus, JP4-039 enhances bone repair and is effective in a combined irradiation injury setting. Supported by NIAID/NIH grant U19AI068021 and BARDA Contract HHSO10200800062C. Disclosures: Roodman: Novartis: Consultancy, Research Funding, Speakers Bureau; Amgen: Consultancy; Celgene: Consultancy; Acceleron: Consultancy.
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Fan, Zhengjie, Xiaomao Sun, Xuesong Mei, and Rujia Wang. "Enhanced Molten Salt Resistance by Sidewall Pores Repair during Fs Laser Drilling of a Thermal Barrier-Coated Superalloy." Materials 12, no. 12 (June 13, 2019): 1905. http://dx.doi.org/10.3390/ma12121905.

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In this study, a novel laser-modified drilling method was used to manufacture cooling holes through thermal barrier coatings (TBCs). Due to the “cooling processing” properties during low-frequency femtosecond (LF-fs) laser drilling, the exposure of the sidewall pores, and the interlayer clearance, the inherent characteristics of plasma-sprayed coatings induced sidewall defects in the drilled holes. After drilling, a high-frequency fs (HF-fs) laser was used to repair the sidewall pores and interlayer clearance of the drilled ceramic holes. Then, the pores and microcracks were healed by local melting using the laser. Moreover, instead of obtaining laser-induced periodic surface structures (LIPSSs), refined and homogeneous grains were produced by the HF-fs laser repair treatment at high transient pressure and temperature. The results from a high-temperature corrosion test showed that healing of the open pores and microstructural improvement in the ceramic hole walls prevented the out-diffusion of Y2O3 stabilizers and the penetration of molten salt, resulting in less corrosive products and producing corresponding phase-transformation stress. Thus, reducing the stabilizer consumption can moderate corrosion fatigue and prolong the lifetime of a cooling hole and TBCs under service.
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Zhang, Xiao Xun, Tuo Lin, Shuang Shuang Zhu, Sheng Ling Zhang, Zhen Wang, and Lei Ha. "Effects of Process Conditions on Crack Healing in 30Cr2Ni4MoV Steel during Hot Forging." Applied Mechanics and Materials 184-185 (June 2012): 854–57. http://dx.doi.org/10.4028/www.scientific.net/amm.184-185.854.

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Internal cracks in 30Cr2Ni4MoV steel were produced by compressing cylindrical sample with drilled hole. In order to consider the effects of deformation degree, temperature, strain rate and holding time on the crack healing, the hot compression tests were performed on Gleeble-1500 thermo-simulation machine under different process conditions. By in situ observation under optical microscope and scanning electron microscope, effects of process condition on crack healing and the behaviours of crack healing were revealed successfully: (1) the result of crack healing improves as the melt temperature, reduction and holding time increase, (2) the effect of crack healing decreases as the strain rate increases. By the energy dispersive spectroscopy, it is also found that the chemical composition of the healed crack area is different from that of the matrix.
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Himabindu, S., and B. Brahma Reddy. "Redundant Actor Based Multi-Hole Healing System for Mobile Sensor Networks." International Journal of Computer Applications Technology and Research 4, no. 12 (December 2, 2015): 923–27. http://dx.doi.org/10.7753/ijcatr0412.1008.

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Deng, Xianjun, Zujun Tang, Laurence Tianruo Yang, Man Lin, and Bang Wang. "Confident Information Coverage Hole Healing in Hybrid Industrial Wireless Sensor Networks." IEEE Transactions on Industrial Informatics 14, no. 5 (May 2018): 2220–29. http://dx.doi.org/10.1109/tii.2017.2764038.

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Claes, L., H. J. Wilke, H. Kiefer, and W. Mutschler. "Biomechanical and morphological properties of healing bone in drill hole defects." Journal of Biomechanics 23, no. 4 (January 1990): 366. http://dx.doi.org/10.1016/0021-9290(90)90075-e.

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., Uppari Naga Pradeep. "AN IMPLEMENTATION OF HOLE DETECTION AND HEALING BY USING HEAL ALGORITHM." International Journal of Research in Engineering and Technology 05, no. 24 (June 25, 2016): 10–13. http://dx.doi.org/10.15623/ijret.2016.0524004.

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Wong, R. M. Y., M. H. V. Choy, M. C. M. Li, K.-S. Leung, S. K-H. Chow, W.-H. Cheung, and J. C. Y. Cheng. "A systematic review of current osteoporotic metaphyseal fracture animal models." Bone & Joint Research 7, no. 1 (January 2018): 6–11. http://dx.doi.org/10.1302/2046-3758.71.bjr-2016-0334.r2.

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ObjectivesThe treatment of osteoporotic fractures is a major challenge, and the enhancement of healing is critical as a major goal in modern fracture management. Most osteoporotic fractures occur at the metaphyseal bone region but few models exist and the healing is still poorly understood. A systematic review was conducted to identify and analyse the appropriateness of current osteoporotic metaphyseal fracture animal models.Materials and MethodsA literature search was performed on the Pubmed, Embase, and Web of Science databases, and relevant articles were selected. A total of 19 studies were included. Information on the animal, induction of osteoporosis, fracture technique, site and fixation, healing results, and utility of the model were extracted.ResultsFracture techniques included drill hole defects (3 of 19), bone defects (3 of 19), partial osteotomy (1 of 19), and complete osteotomies (12 of 19). Drill hole models and incomplete osteotomy models are easy to perform and allow the study of therapeutic agents but do not represent the usual clinical setting. Additionally, biomaterials can be filled into drill hole defects for analysis. Complete osteotomy models are most commonly used and are best suited for the investigation of therapeutic drugs or noninvasive interventions. The metaphyseal defect models allow the study of biomaterials, which are associated with complex and comminuted osteoporotic fractures.ConclusionFor a clinically relevant model, we propose that an animal model should satisfy the following criteria to study osteoporotic fracture healing: 1) induction of osteoporosis, 2) complete osteotomy or defect at the metaphysis unilaterally, and 3) internal fixation. Cite this article: R. M. Y. Wong, M. H. V. Choy, M. C. M. Li, K-S. Leung, S. K-H. Chow, W-H. Cheung, J. C. Y. Cheng. A systematic review of current osteoporotic metaphyseal fracture animal models. Bone Joint Res 2018;7:6–11. DOI: 10.1302/2046-3758.71.BJR-2016-0334.R2.
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Nečas, Alois, Pavel Proks, Lucie Urbanová, Robert Srnec, Ladislav Stehlík, Michal Crha, Petr Raušer, et al. "Radiographic Assessment of Implant Failures of Titanium 3.5 LCP vs. 4.5 LCP Used for Flexible Bridging Osteosynthesis of Large Segmental Femoral Diaphyseal Defects in a Miniature Pig Model." Acta Veterinaria Brno 79, no. 4 (2010): 599–606. http://dx.doi.org/10.2754/avb201079040599.

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The study describes types, absolute and relative numbers of implant failures in flexible bridging osteosynthesis using a six-hole 3.5 mm titanium Locking Compression Plate (n = 9) or a five-hole LCP 4.5 mm titanium (n = 40) selected for the fixation of segmental ostectomy of femoral diaphysis in the miniature pig used as an in vivo model in a study on the healing of a critically sized bone defect using transplantation of mesenchymal stem cells combined with biocompatible scaffolds within a broader research project. Occasional implant failure was evaluated based on radiographic examination of femurs of animals 2, 4, 8, 12 and 16 weeks after surgery. When bone defect was stabilized using 3.5 mm LCP, in 6 cases (66.7%) the screw was broken/lost in the proximal fragment of the femur 2 weeks after implantation (n = 4) and 4 weeks after implantation (n = 2). In 4 cases of these, the implant failure was accompanied also by loosening of the screw in position 3 in the proximal fragment of the femur. During ostectomy stabilization with 4.5 mm LCP, in 3 cases (7.5%) LCP was broken at the place of the empty central plate hole (without inserted screw) at the level of the segmental bone defect. Compared to the six-hole 3.5 mm LCP, the five-hole titanium 4.5 mm LCP is more suitable implant for flexible bridging osteosynthesis of a critically sized segmental defect of femoral diaphysis in the miniature pig. The results of this study will allow reducing implant failures in time- and cost-demanding transplantation experiments focused on bone healing.
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Lomakin, M. V., I. I. Soloshchanskii, A. A. Pokhabov, and H. U. Bisultanov. "Method for quantitative assessment of surgical wound healing (for example, the hole of a removed tooth). Part I." Parodontologiya 25, no. 4 (December 19, 2020): 349–56. http://dx.doi.org/10.33925/1683-3759-2020-25-4-349-356.

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Relevance. Surgical stages of the dental implant restoration are an indispensable part of the treatment procedures. However, underestimation of residual/ available alveolar bone volume after tooth extraction may challenge implantation planning. Socket healing process might depend on either a surgical technique, or local or systemic preexisting factors, that this study should present as quantitative data. Purpose is to develop a technique for quantitative assessment of a surgical wound healing, e.g. an extraction socket.Materials and methods. The study included 42 patients after extraction of different teeth during the preparatory procedures for further dental arch restoration with implants. Follow-ups, clinical data, laboratory and radiographic findings determined clinical, radiographic, and information values – dependent and independent variables as quantifiable clinical parameters – biomarkers; they were statistically analyzed.Results. The conducted analysis revealed correlation dependence between selected parameters. Highly significant interrelationship allowed calculating the overall success rate of wound/ socket healing after tooth extraction. A regression model was developed to explain 76% healing success rate.Conclusion. Thus, factors and conditions determining the healing of a surgical bone wound, e.g. an extraction socket, consistently affect each other. Numerical sequences of real-life processes characterize the extent and highly significant interrelations and allow predicting the mutual impact of the factors.
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WANG, Xingang, Xingjing WANG, Yuhao XIE, and Wei XU. "Early Age Strength Healing Effect of Cementitious Composite Incorporated Self-Healing Microcapsule." Materials Science 27, no. 2 (May 5, 2021): 133–39. http://dx.doi.org/10.5755/j02.ms.22841.

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Received 27 February 2019; accepted 02 September 2019 This paper aims to explore early age strength healing effect of cementitious composite incorporated self-healing microcapsule and curing activity of self-healing microcapsule. Particle characteristic of the microcapsule and micromorphology of cement paste incorporated the microcapsule were characterized by SEM. Curing activity of the microcapsule was analyzed by macroscopic solidification test, DSC and TGA. The influence factors of early age strength healing ratio in cementitious composite incorporated self-healing microcapsule were studied. The results showed that epoxy resin microcapsule had favorable micromorphology. Epoxy resin microcapsule core material had good curing activity and possessed the ability to play the healing role in cementitious composite. Healing temperature and healing age had less impact on the healing effect of the microcapsule in cementitious composite. The microcapsule could be kept good shape in cement paste and combined with cement paste closely. The microcapsule also could rupture and had better dispersion in cement paste. The main fracture behavior of the microcapsule was based on small hole ruptured when cement paste did not occur macro damage. When pre-loading was 0.75 σmax, the particle size of microcapsules was range from 75 μm to 150 μm, proportion of epoxy curing agent was 20 % and proportion of the microcapsule was 6 %, early age strength healing ratio reached the highest of 24.1 %.
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Stack, Robert. "Effect of Tree Size, Hole Location, and Wetwood Fluxing on Healing of Injection Wounds in American Elms." Arboriculture & Urban Forestry 11, no. 2 (February 1, 1985): 45–47. http://dx.doi.org/10.48044/jauf.1985.011.

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Elm trees treated by injection for protection from Dutch elm disease were examined after 22 months. The degree of healing of injection wounds was determined. Injection holes in roots healed faster than those in stems, and with notable exceptions those on smaller trees faster than those on larger trees. There was no relationship between wetwood symptoms on the tree and healing of injection sites.
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PRONGMANEE, Nutthachai, and Jin-Chun CHAI. "Effect of Shape of Damage Hole on Self-Healing Capacity of GCL." Geosynthetics Engineering Journal 32 (2017): 59. http://dx.doi.org/10.5030/jcigsjournal.32.59.

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50

Rezende, Flávio A., and Michael A. Kapusta. "Internal limiting membrane: ultrastructural relationships, with clinical implications for macular hole healing." Canadian Journal of Ophthalmology 39, no. 3 (April 2004): 251–59. http://dx.doi.org/10.1016/s0008-4182(04)80122-4.

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