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Статті в журналах з теми "Histology"

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Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 22 червня 2024

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1

Shaw, Phyllis A., and Erica S. Friedman. "Clinico-Histologic Conferences: Histology and disease." Anatomical Sciences Education 5, no. 1 (December 5, 2011): 55–61. http://dx.doi.org/10.1002/ase.1252.

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2

Langer, Corey J., Benjamin Besse, Antonio Gualberto, Elizabeth Brambilla, and Jean-Charles Soria. "The Evolving Role of Histology in the Management of Advanced Non–Small-Cell Lung Cancer." Journal of Clinical Oncology 28, no. 36 (December 20, 2010): 5311–20. http://dx.doi.org/10.1200/jco.2010.28.8126.

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Until recently, non–small-cell lung cancer (NSCLC) was treated as a single disease despite recognition of its histologic and molecular heterogeneity. Recent clinical trials, however, demonstrate that histology is an important factor for individualizing treatment, based on either safety or efficacy outcomes. For example, the labeling of the licensed agents bevacizumab and pemetrexed is restricted to patients with nonsquamous cell NSCLC. For bevacizumab, this restriction is due to an apparent association between squamous cell histology and severe pulmonary hemorrhage, whereas for pemetrexed, superior treatment effects have been observed in patients with nonsquamous cell histology. Given fewer agents are both active and tolerable in patients with squamous cell carcinoma compared with adenocarcinoma, and the nature of this particular phenotype of NSCLC, new drugs are needed for this histology. In this new histology-based treatment era, questions persist. Can pathology accurately distinguish the histologic subtypes of NSCLC? Can we use cytologic diagnosis? In the future, will molecular profiling of tumors trump histologic analysis? Herein we describe how therapy for NSCLC is evolving on the basis of a better understanding of molecular mechanisms underlying NSCLC histologic heterogeneity and tumorigenesis.

3

Tefferi, A., R. A. Zellers, P. M. Banks, T. M. Therneau, and J. P. Colgan. "Clinical correlates of distinct immunophenotypic and histologic subcategories of lymphocyte-predominance Hodgkin's disease." Journal of Clinical Oncology 8, no. 12 (December 1990): 1959–65. http://dx.doi.org/10.1200/jco.1990.8.12.1959.

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Histologic and paraffin immunohistologic studies were carried out on 32 patients with lymphocyte-predominance Hodgkin's disease (LPHD) seen from 1970 through 1982. While nodular histology was accurately predictive of B-cell phenotype (Leu M1 -/L26+), diffuse histology corresponded to either B-cell or Hodgkin's (Leu M1 +/L26-) phenotype, not invariably predictable even when attention was paid to subtle paragranuloma cytology. Clinical characteristics were compared between histologic (diffuse v nodular) and immunophenotypic (Leu M1 +/L26-, Hodgkin's phenotype, v Leu M1 -/L26+, B-cell phenotype) subgroups. Ten patients have since died, and the median follow-up of the living patients was 14 years (range, 6 to 31). Of the several clinical parameters compared, only axillary nodal presentation was strongly associated with both B-cell phenotype and nodular histology, while male predominance related more to B-cell phenotype than nodular histology. No significant difference in overall survival or relapse rate was apparent among either the histologic or the immunophenotypic subgroups. However, very late but salvageable relapses were associated with nodular histology. The incidences of secondary malignancies and death from Hodgkin's disease (HD) were also comparable between the subgroups. Although difference in clinical presentation may exist, neither the histologic nor the immunophenotypic subcategories of LPHD could be demonstrated to correlate with differences in clinical outcome.

4

Vázquez, José. "Histology." American Biology Teacher 66, no. 6 (August 1, 2004): 454–55. http://dx.doi.org/10.2307/4451714.

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5

Curi, Rui. "Histology." Brazilian Journal of Pharmaceutical Sciences 47, no. 1 (March 2011): 196–97. http://dx.doi.org/10.1590/s1984-82502011000100031.

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6

DONNEZ, JACQUES, and FRANCOISE CASANAS-ROUX. "Histology." Obstetrical & Gynecological Survey 44, no. 4 (April 1989): 281–83. http://dx.doi.org/10.1097/00006254-198904000-00020.

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7

Jones, R. H., and C. A. R. Boyd. "Histology." Trends in Cell Biology 2, no. 4 (April 1992): 120. http://dx.doi.org/10.1016/0962-8924(92)90018-i.

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8

Cox, F. E. G. "Histology." Parasitology Today 8, no. 8 (August 1992): 290. http://dx.doi.org/10.1016/0169-4758(92)90159-y.

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9

Meyer, Harriet S. "Histology." JAMA 286, no. 1 (July 4, 2001): 95. http://dx.doi.org/10.1001/jama.286.1.95-jbk0704-1a-1.

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10

Tang, Ming, Neda Kalhor, Maheshwari Ramineni, Junya Fujimoto, Jianhua Zhang, Jun Li, Chi-Wan Chow, et al. "Histology determination of lung cancers: A report on genomic profiling of lung cancer of mixing histology." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 8570. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.8570.

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8570 Background: Histopathology, largely determined by morphology, plays a critical role in choosing appropriate treatment for lung cancer. The understanding of molecular determination of lung cancer histology is rudimentary. Our recently published data (Zhang, Science, 2014 and Liu, Nature Communications, 2016) have demonstrated that within the same patients with identical genetic background and identical exposure, tumor regions with different morphologic appearances may have very similar genomic profiles while tumors with the same morphology may have distinct genomic landscape. Methods: We collected 12 lung cancers of mixing histology with 2 to 4 histologic components within each tumor. In total, 26 tumor regions including 9 adenocarcinomas, 6 large-cell neuroendocrine carcinoma, 6 small cell carcinomas and 4 squamous cell carcinomas and one poorly differentiated lung carcinoma were microdissected and subjected to whole exome sequencing. Results: A substantial number of identical mutations were shared between different histologic components within the same tumor in all 12 patients. However, the proportion of shared mutations varies in different patients ranging from as little as 4% to as much as 99%. Mutation spectrum is also similar between different histologic components within the same tumors suggesting similar mutational process in place. Identical canonical cancer gene mutations including TP53, KRAS, PIK3CA, SOS1 and STK11 are generally shared between different histologic components within the same tumors. Canonical mutations in FBXW7 and MTHFR were detected in squamous component, but not small-cell component in one patient. Conclusions: Different histologic components of lung cancers of mixing histology are likely derived from the same progenitor cells, but the molecular timing of branch separation of subclones giving rise to different histologic components varies in different tumors. Although genomic aberrations may play a role in a subset of tumors, histologic features may not be determined at genomic level for most lung cancers. Gene expression and methylation analyses from these tumors are underway.

11

Li, Guo-Liang, Guy Fontaine, Jine Wu, Shuanliang Fan, Chaofeng Sun, and Ardan M. Saguner. "Atrial dysplasia in the atria of humans without cardiovascular disease." Journal of Investigative Medicine 67, no. 6 (February 14, 2019): 971–76. http://dx.doi.org/10.1136/jim-2018-000916.

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Research on atrial histology of humans without cardiovascular disease is scarce. Therefore, our aim was to study human atrial histology in subjects without cardiovascular disease. Histology of the right atrium, left atrium or atrial septum was studied in eight patients (one newborn infant and seven adults) who died of a non-cardiac cause and who were not known to suffer from any cardiovascular pathology. Staining with hematoxylin phloxine saffron or Masson’s trichrome was performed to have a better identification of fibrosis and H&E for better identification of lymphocytes. Atrial histology was compared with the histology of the left ventricle and was taken from a collection of standard glass slides. Common light microscopic examination and numeric image processing was performed in all samples. Left atrial histology showed a substantial amount of adipocytes and interstitial fibrosis, associated with replacement fibrosis in some of these cases including one case of lymphocytic infiltrates, similar to the histologic changes of the right ventricle (RV) known in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVD). Furthermore, we identified a perpendicular orientation of atrial myocardial fibres, which is also a feature of the thin RV free wall. A similar histologic substrate to the RV myocardium known in ARVD is found in the atria of humans without an overt cardiovascular pathology. This may explain the high prevalence of atrial fibrillation in the general population.

12

Luo, Jiaqian, Sizhi P. Gao, Fengshen Kuo, Gamze Gokturk Ozcan, Merve Basar, Florestan Koll, Jacob E. Tallman, et al. "Abstract 4632: Lineage plasticity as a determinant of antibody-drug conjugate target expression in urothelial bladder cancer." Cancer Research 84, no. 6_Supplement (March 22, 2024): 4632. http://dx.doi.org/10.1158/1538-7445.am2024-4632.

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Abstract Bladder cancers display a wide spectrum of morphologies that frequently co-exist within individual tumors. Several histologic variants, including plasmacytoid, neuroendocrine, and micropapillary subtypes, are associated with an increased bladder cancer recurrence risk and cancer-specific mortality. The molecular basis and therapeutic implications of this phenotypical plasticity remain poorly understood. Enfortumab vedotin (EV), an antibody-drug conjugate targeting Nectin-4, has also emerged as a new standard-of-care for metastatic bladder cancer patients, but the association between lineage plasticity as manifested by morphologic heterogeneity in bladder cancer, Nectin-4 expression and ADC response remains poorly defined. Previous DNA-based molecular profiling studies of histologic variants revealed that CDH1 mutations were the pathognomonic molecular alteration in plasmacytoid urothelial carcinoma, but no recurrent driver mutations have been found to be unique to the aberrant histology regions of other mixed histology subtypes. Thus, to explore the molecular basis for the lineage plasticity of bladder cancers with aberrant histology and to define the association between lineage plasticity manifested as morphologic heterogeneity and the expression of Nectin-4, HER2 and other potential ADC targets, we performed RNA-seq of pure urothelial carcinomas (n=118, not otherwise specified, UC-NOS) and bladder tumors with divergent differentiation or histologic subtypes (n=199). Our cohort included a subset of tumors in which RNA-seq was performed on microdissected UC-NOS and variant histology regions of the same tumor. Tumors with neuroendocrine, sarcomatoid and squamous histology had the lowest Nectin-4 expression, whereas histologic subtypes that retained a luminal transcriptional profile such as micropapillary, plasmacytoid and nested histology had higher levels of Nectin-4 expression. In mixed histology tumors, Nectin-4 and/or HER2 expression was often restricted to only one of the two histologic components. Gene Set Enrichment Analysis noted enrichment of distinct oncogenic pathway gene sets in different histologic variants. Preliminary investigation into the mechanism(s) of Nectin-4 regulation using bladder cancer cell lines and patient-derived organoids (PDOs) has identified targetable pathways which when inhibited revert lineage plasticity and induce Nectin-4 expression. In sum, lineage plasticity manifested as heterogenous histomorphologies was associated with heterogeneous Nectin-4 expression in some but not all histologic variants of bladder cancer. Ongoing studies using PDOs from bladder cancer patients with mixed histology will seek to identify molecular pathways whose inhibition leads to increased expression of Nectin-4 or other ADC targets such as HER2 and thus increased sensitivity of ADCs targeting these cell surface proteins. Citation Format: Jiaqian Luo, Sizhi P. Gao, Fengshen Kuo, Gamze Gokturk Ozcan, Merve Basar, Florestan Koll, Jacob E. Tallman, Syed M. Alam, Carissa E. Chu, Ziyu Chen, Eugene J. Pietzak, Gopakumar Iyer, Jonathan E. Rosenberg, David B. Solit, Hikmat Al-Ahmadie. Lineage plasticity as a determinant of antibody-drug conjugate target expression in urothelial bladder cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4632.

13

Rudzinski, Erin R. "Histology and Fusion Status in Rhabdomyosarcoma." American Society of Clinical Oncology Educational Book, no. 33 (May 2013): 425–28. http://dx.doi.org/10.14694/edbook_am.2013.33.425.

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The International Classification of Rhabdomyosarcoma (ICR) has provided diagnostic criteria for rhabdomyosarcoma (RMS) and formed the basis of histologic risk stratification since its publication in 1995. However, the recognition of new variants of embryonal rhabdomyosarcoma (ERMS), shifts in the diagnostic criteria of alveolar rhabdomyosarcoma (ARMS), the increasing use of myogenin immunohistochemistry and recognition of the distinct biologic properties associated with fusion status all raised questions about the continued use of this classification system in the diagnosis and treatment of patients with RMS. Recent Children's Oncology Group Soft Tissue Sarcoma Committee analysis of histology and fusion status in the intermediate risk RMS study D9803 refined the histologic criteria of RMS. We validated the new diagnostic criteria against fusion status, allowing prospective examination of the prognostic value of histology compared with fusion status for risk-stratification of patients with RMS. This article summarizes the evolution of and current practices in the histologic and molecular classification of rhabdomyosarcoma.

14

Damjanov, Ivan. "Book ReviewTextbook of Histology Atlas of Histology." New England Journal of Medicine 313, no. 25 (December 19, 1985): 1614–15. http://dx.doi.org/10.1056/nejm198512193132527.

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15

Spaliviero, Massimiliano, Kelly Lynn Stratton, Timothy F. Donahue, Banumathy Gowrishankar, Charles Ma, Jeremy C. Durack, Stephen Barnett Solomon, Jane Houldsworth, and Jonathan A. Coleman. "Fluorescence in situ hybridization (FISH) and array-comparative genomic hybridization (a-CGH) from percutaneous needle biopsy compared to renal mass histology." Journal of Clinical Oncology 31, no. 6_suppl (February 20, 2013): 471. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.471.

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471 Background: Image-guided percutaneous needle biopsies are increasingly utilized for the diagnosis of renal tumors. Histologic diagnosis of renal mass subtypes, including malignant clear cell (ccRCC), papillary (pRCC), chromophobe (chrRCC) renal cell carcinoma, and benign oncocytomas (OC) can be challenging due to the low cellularity and damaged architecture of needle biopsy specimens. However, each subtype exhibits unique genetic aberrations that can assist in histologic classification and potentially assist in guiding management decisions. We report our initial experience correlating renal mass histology to subtype-associated genomic alterations detected by FISH and a-CGH of percutaneous needle biopsy specimens. Methods: In an ongoing IRB-approved blinded study, 17 samples obtained from 15 patients with known renal masses were submitted to FISH (FReCaD) and targeted a-CGH (UroGenRA-Kidney). Specimens were classified using a subtype classification decision tree algorithm based on the presence/absence of genomic abnormalities. The results were compared to biopsy histology or surgical specimen when available. Results: Histology revealed ccRCC in 6 patients, pRCC in 4, OC in 2, Angiomyolipoma in 1, and unclassified type RCC in 2. In 6 of 9 cases FISH achieved a diagnosis, which correlated with histology in 4. FISH incorrectly classified as ccRCC two cases with pRCC on histology. A-CGH was diagnostic in 14 of 15 cases and correlated with histology in 13. In one case, a-CGH showed a genomic profile not consistent with ccRCC, pRCC, chrRCC, or OC according to the algorithm. Conclusions: The addition of genetic tumor tissue studies to complement histology from biopsy tissues may supplement or improve the accuracy of classification and biological characterization of renal tumor biopsies and influence treatment planning. In our initial experience, a-CGH showed better correlation with histology in subtype classification of malignant and benign renal masses than FISH. Prospective testing will be required to validate these results.

16

Shankar, A. G., S. Ashley, M. Radford, A. Barrett, D. Wright, and C. R. Pinkerton. "Does histology influence outcome in childhood Hodgkin's disease? Results from the United Kingdom Children's Cancer Study Group." Journal of Clinical Oncology 15, no. 7 (July 1997): 2622–30. http://dx.doi.org/10.1200/jco.1997.15.7.2622.

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PURPOSE Histology has been identified as an important prognostic factor in Hodgkin's disease (HD) in adults. Information regarding the impact of histology on outcome in childhood HD is scarce. This study determines the effect of histology on the overall survival (OS) or progression-free survival (PFS) in a national series of children treated in a standardized manner. PATIENTS AND METHODS The results of treatment of 331 assessable patients, treated between January 1, 1982 and June 30, 1992, in the United Kingdom Children's Cancer Study Group (UKCCSG) Hodgkin's study I were reviewed to evaluate OS, PFS, and deaths according to stage and histology. Treatment was either involved-field radiation alone (stage IA) or chlorambucil, vinblastine, procarbazine, and prednisolone (ChlVPP) chemotherapy with or without mediastinal radiation. All were clinically staged at diagnosis. RESULTS Nodular sclerosing (NS) HD was the most common histologic subtype (155 of 331 patients [47%]) and was uniformly distributed through all stages. Lymphocyte-depletion (LD) HD was extremely uncommon (< 1%). Mixed-cellularity (MC) HD had the highest relapse rate, but this was only significant (P < .05) in stage I patients who received local irradiation alone. There was no other statistically significant difference in OS and PFS between the various histologic subtypes. Multivariate analysis for PFS and OS confirmed that stage was the most important prognostic factor and that histology did not have an effect after stratification by stage. CONCLUSION This study demonstrates that with effective multiagent chemotherapy, histologic subtype does not influence outcome. The high relapse rates in stage I MC subtype indicates that MC HD is biologically aggressive and systemic treatment with or without local irradiation may be indicated. The high relapse rate in stage IV patients appeared to be independent of histology.

17

N, Ghalawat, and Rathee S.K. "HISTOLOGY OF MENISCO-FEMORAL LIGAMENT." International Journal of Anatomy and Research 5, no. 2.2 (May 31, 2017): 3833–35. http://dx.doi.org/10.16965/ijar.2017.195.

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18

Nikolay, Kostv, and Tayfun E. Tezduyar. "2B15 Histology-based prestress for arterial FSI computations : Histology-based prestress for arterial FSI computations." Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2013.25 (2013): 301. http://dx.doi.org/10.1299/jsmebio.2013.25.301.

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19

Citra Pratiwi, Harini, and Abdul Manan. "Teknik Dasar Histologi pada Ikan Gurami (Osphronemus gouramy) [ The Basic Histology Technique of Gouramy Fish (Osphronemus gourami)]." Jurnal Ilmiah Perikanan dan Kelautan 7, no. 2 (January 13, 2019): 153. http://dx.doi.org/10.20473/jipk.v7i2.11199.

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Abstract Histology is science that learns about cell,organ, and body tissues in a microscopic condition. Whereas science that learns about morbidity or patology of a tissue that’s called as histopatology. Both of normal tissue’s structure and abnormal tissue’s stucturecan be learned by microscopic in a tissue preparation. This preparation made through processing of tissue until the preparation coloured. Then histology’s structure can be watched clearly so that make it easy to read. Field Work Practice purpose (PKL) this is to know the basic histoloy technique in fish. This Field Work Practice was held in Balai Uji Standar Karantina Ikan Pengendalian Mutu dan Keamanan Hasil Perikanan (BUSKIPM) Jl. Harapan I No. 01A Cilangkap, East Jakarta on 14th January 2013 until 14th February 2013. The method of this Field Work Practice is descriptive method by collecting data through primary data and secondary data. The histology technique in fish are tissue fixation, trimming (tissue selection), tissue dehydration, the tissue block making, tissue cutting, tissue colouring, and tissue observation. From the result got from the gourami’s tissue, there are edema and infestation of metacercaria parasites and myxosporidia in gill normal intestine tissue, normal liver tissue, and normal spleen tissue

20

Rousselle, Serge D., Joan R. Wicks, Brian C. Tabb, Armando Tellez, and Maureen O’Brien. "Histology Strategies for Medical Implants and Interventional Device Studies." Toxicologic Pathology 47, no. 3 (February 14, 2019): 235–49. http://dx.doi.org/10.1177/0192623319827288.

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Histology of medical devices poses a variety of unique challenges. Comprehensive histologic assessment of medical devices often requires spatial context and high-quality retention of the device–tissue interface. However, the composition of many medical devices is often not amenable to traditional paraffin embedding and thus alternative specialized methodologies such as hard resin embedding must be used. Hard resin embedding requires specialized laboratory technical expertise and equipment, and the fixation techniques and resin composition used markedly impact the feasibility of immunohistochemistry. For the continuity of spatial context during histologic evaluation, additional imaging methods such as macrophotography, radiography, micro-Computerized Tomography (microCT), or magnetic resonance imaging (MRI) can be used to guide sectioning and to complement histologic findings. Although standardized approaches are scarce for medical devices, important considerations specific to medical device histology are discussed, including general specimen preparation, special considerations for devices by organ system, and the challenges of immunohistochemistry. Histologic preparation of medical devices must be thoughtful, thorough, and tailored to achieve optimal histologic outcomes for complex, valuable, and often limited implant specimens.

21

Redi, CarloAlberto. "Histology protocols." European Journal of Histochemistry 54, no. 2 (June 7, 2010): 27. http://dx.doi.org/10.4081/ejh.2010.e27.

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22

Porten, Sima P., Daniel Willis, and Ashish M. Kamat. "Variant histology." Current Opinion in Urology 24, no. 5 (September 2014): 517–23. http://dx.doi.org/10.1097/mou.0000000000000089.

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23

Condel, Jennifer L., Drazen M. Jukic, David T. Sharbaugh, and Stephen S. Raab. "Histology Errors." Pathology Case Reviews 10, no. 2 (March 2005): 82–87. http://dx.doi.org/10.1097/01.pcr.0000155793.51378.ba.

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24

Lane, Nancy J. "Picture histology." Nature 323, no. 6085 (September 1986): 211. http://dx.doi.org/10.1038/323211a0.

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25

McMillan, D. A. "Picture histology." Nature 323, no. 6085 (September 1986): 211. http://dx.doi.org/10.1038/323211b0.

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26

Konig, A., and V. Klauss. "Virtual histology." Heart 93, no. 8 (August 1, 2007): 977–82. http://dx.doi.org/10.1136/hrt.2007.116384.

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27

Fleming, S. "Basic Histology." Histopathology 16, no. 5 (April 3, 2007): 511. http://dx.doi.org/10.1111/j.1365-2559.1990.tb01556.x.

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28

Travis, Lisa D. "Histology Resources." Journal of Electronic Resources in Medical Libraries 12, no. 2 (April 3, 2015): 126–33. http://dx.doi.org/10.1080/15424065.2015.1036664.

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29

Gasmi, Billel, and David E. Kleiner. "Liver Histology." Clinics in Liver Disease 24, no. 1 (February 2020): 61–74. http://dx.doi.org/10.1016/j.cld.2019.09.004.

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30

Fogo, Agnes B. "Kidney Histology." Clinical Therapeutics 34, no. 4 (April 2012): e11. http://dx.doi.org/10.1016/j.clinthera.2012.03.019.

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31

Hadley, Gina. "Basic Histology." Journal of Anatomy 211, no. 3 (September 2007): 412. http://dx.doi.org/10.1111/j.1469-7580.2007.771_1.x.

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32

Ecker, H. A. "Oral Histology." Plastic and Reconstructive Surgery 80, no. 6 (December 1987): 860. http://dx.doi.org/10.1097/00006534-198712000-00025.

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33

Borczuk, Alain C. "Micropapillary Histology." American Journal of Clinical Pathology 131, no. 5 (May 2009): 615–17. http://dx.doi.org/10.1309/ajcp9na3yqswdyun.

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34

Jeans, A., and M. Esiri. "Brain histology." Practical Neurology 8, no. 5 (October 1, 2008): 303–10. http://dx.doi.org/10.1136/jnnp.2008.156893.

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35

Kiesslich, Ralf, Martin Goetz, and Markus F. Neurath. "Virtual histology." Best Practice & Research Clinical Gastroenterology 22, no. 5 (October 2008): 883–97. http://dx.doi.org/10.1016/j.bpg.2008.05.003.

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36

Burns, E. Robert. "Clinical histology." Clinical Anatomy 19, no. 2 (November 10, 2005): 156–63. http://dx.doi.org/10.1002/ca.20212.

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37

Cotton, D. W. K., and T. J. Stephenson. "Autopsy histology." Journal of Pathology 154, no. 4 (April 1988): 299–300. http://dx.doi.org/10.1002/path.1711540404.

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38

Park, Jun Won, Geon Kook Lee, Hee Seok Lee, Jae Ill Zo, Young Hwan Kim, Kwang Pyo Kim, and Hark K. Kim. "Histology differentiation in non-small cell lung cancer using matrix-assisted laser desorption/ionization mass spectrometry." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): e21043-e21043. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e21043.

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e21043 Background: New developments in the treatment of lung cancer have necessitated the correct histologic differentiation between two major histologic types of NSCLC. Methods: Histology-directed tissue matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) has been demonstrated to be useful for molecular profiling of common solid tumors. In this approach, mass spectra are obtained from discrete locations on the thin sections of frozen tissues sections. In this study, we evaluated various MALDI MS protocols for the histopathologic classification of NSCLC. Results: When adenocarcinoma and squamous cell carcinoma biopsy samples were compared for protein profile using standard sinapinic acid matrix, the median prediction accuracy of the best histology classifier in test sets was 83.3% in 100 random training-to-test partitions (feature selection P <0.05). When 2,5-dihydroxybenzoic acid/α-cyano-4-hydroxycinnamic acid matrices were used for lipid MALDI MS, the median prediction accuracy of the best histology classifier in test sets was 85.7% in 100 random partitions (feature selection P<0.01). We then validated the discriminatory lipid profile using independent set of 51 NSCLC surgical samples. Eleven discriminatory lipids correctly classified the histology of 80.4% of independent NSCLC surgical tissue samples (41 out of 51) in validation set. Phosphatidylcholine 32:0 (m/z 756.68) was overexpressed in adenocarcinomas. Conclusions: Due to the small amount of tissue required for MALDI analysis, rapid experimental procedure, and high predictive values documented in this study, histology-directed MALDI MS, especially lipid profiling, may be a promising approach to the histologic classification of NSCLC (This work was supported by Converging Research Center Program through the Ministry of Education, Science and Technology of Korea (2010K001121)).

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Wilkins, B. S. "Histology of normal haemopoiesis: bone marrow histology. I." Journal of Clinical Pathology 45, no. 8 (August 1, 1992): 645–49. http://dx.doi.org/10.1136/jcp.45.8.645.

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Tripathi, Abhishek, Mark A. Preston, Michelle S. Hirsch, Quoc-Dien Trinh, James A. Stewart, Joaquim Bellmunt, Toni K. Choueiri, Adam S. Kibel, and Lauren Christine Harshman. "Impact of variant histology on disease-specific mortality and survival in patients with non-muscle invasive bladder cancer (NMIBC): A population-based analysis." Journal of Clinical Oncology 35, no. 6_suppl (February 20, 2017): 332. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.332.

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332 Background: Prior studies have reported that variant histology is associated with poor outcomes in NMIBC. We utilized the Surveillance, Epidemiology and End Results (SEER) database to compare disease specific survival (DSS) and mortality (DSM) among the different variant histologies and urothelial carcinoma (UC). Methods: Patients diagnosed with NMIBC (Ta, Tis, T1) between 2004 and 2012 were eligible for analysis. Patients were separated into cohorts based on histology: UC and variant histology which included micro-papillary variant (MPV), neuroendocrine (NEC), squamous (SCC), adenocarcinoma (AC) and other variants (e.g., lymphoepithelial, giant cell, undifferentiated/anaplastic, sarcomatoid). Univariate and multivariable Cox proportional hazard analysis was used to evaluate the impact of variant histology on DSM after adjusting for other covariates. DSS was estimated amongst the different histologic and treatment groups using the Kaplan-Meier method and compared using Log-rank test. Results: We identified 111,756 patients, who were predominantly Caucasian (90%) and older than 70 years (57.5%; n=64,314). Variant histology accounted for 1.2% (n=1354) of cases. AC and SCC were the most common variant subtypes (26.4%; n=357 and 25.6%; n=347 respectively) followed by NEC (11.2%; n=151) and MPV (7.1%; n=96). On multivariable analysis adjusting for age, sex, race, T-stage, histologic grade and number of primary tumors, all variant subgroups except MPV were associated with increased DSM compared to UC (p<0.001). SCC had the worst 5-year DSS (53.8%; P<0.001) followed by NEC (65.1%) and AC (77.8%). Compared to treatment with TURBT or intravesical BCG, cystectomy was associated with improved DSS for variant histology patients with T1 tumors (75.8% vs. 66.3%; P<0.001). Conclusions: Variant histology, specifically SCC and NEC, was associated with significantly worse 5-year DSS in NMIBC. MPV, which is generally thought to be aggressive, had outcomes comparable to UC. Cystectomy was associated with improved DSS in patients with T1 disease and should be considered for NMIBC with variant histology.

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Bhattacharya, Sumona, and Raymond K. Cross. "Is Endoscopic Remission in Ulcerative Colitis Still Good Enough?" Inflammatory Bowel Diseases 25, no. 11 (August 14, 2019): 1729–30. http://dx.doi.org/10.1093/ibd/izz177.

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Histology is a treatment target for investigational agents. Histologic activity predicts relapses and increased risk of colorectal neoplasia. Recent studies demonstrated that the proportion of patients achieving histologic improvement is low. Research is needed before providers treat to histologic remission.

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Rahaman, Petra, and Marc R. Del Bigio. "Histology of Brain Trauma and Hypoxia-Ischemia." Academic Forensic Pathology 8, no. 3 (August 31, 2018): 539–54. http://dx.doi.org/10.1177/1925362118797728.

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Forensic pathologists encounter hypoxic-ischemic (HI) brain damage or traumatic brain injuries (TBI) on an almost daily basis. Evaluation of the findings guides decisions regarding cause and manner of death. When there are gross findings of brain trauma, the cause of death is often obvious. However, microscopic evaluation should be used to augment the macroscopic diagnoses. Histology can be used to seek evidence for TBI in the absence of gross findings, e.g., in the context of reported or suspected TBI. Estimating the survival interval after an insult is often of medicolegal interest; this requires targeted tissue sampling and careful histologic evaluation. Retained tissue blocks serve as forensic evidence and also provide invaluable teaching and research material. In certain contexts, histology can be used to demonstrate nontraumatic causes of seemingly traumatic lesions. Macroscopic and histologic findings of brain trauma can be confounded by concomitant HI brain injury when an individual survives temporarily after TBI. Here we review the histologic approaches for evaluating TBI, hemorrhage, and HI brain injury. Amyloid precursor protein (APP) immunohistochemistry is helpful for identifying damaged axons, but patterns of damage cannot unambiguously distinguish TBI from HI. The evolution of hemorrhagic lesions will be discussed in detail; however, timing of any lesion is at best approximate. It is important to recognize artifactual changes (e.g., dark neurons) that can resemble HI damage. Despite the shortcomings, histology is a critical adjunct to the gross examination of brains.

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Callemeyn, Jasper, Evelyne Lerut, Henriette de Loor, Ingrid Arijs, Olivier Thaunat, Alice Koenig, Vannary Meas-Yedid, et al. "Transcriptional Changes in Kidney Allografts with Histology of Antibody-Mediated Rejection without Anti-HLA Donor-Specific Antibodies." Journal of the American Society of Nephrology 31, no. 9 (July 8, 2020): 2168–83. http://dx.doi.org/10.1681/asn.2020030306.

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BackgroundCirculating donor-specific anti-HLA antibodies (HLA-DSAs) are often absent in serum of kidney allograft recipients whose biopsy specimens demonstrate histology of antibody-mediated rejection (ABMR). It is unclear whether cases involving ABMR histology without detectable HLA-DSAs represent a distinct clinical and molecular phenotype.MethodsIn this multicenter cohort study, we integrated allograft microarray analysis with extensive clinical and histologic phenotyping from 224 kidney transplant recipients between 2011 and 2017. We used the term ABMR histology for biopsy specimens that fulfill the first two Banff 2017 criteria for ABMR, irrespective of HLA-DSA status.ResultsOf 224 biopsy specimens, 56 had ABMR histology; 26 of these (46.4%) lacked detectable serum HLA-DSAs. Biopsy specimens with ABMR histology showed overexpression of transcripts mostly related to IFNγ-induced pathways and activation of natural killer cells and endothelial cells. HLA-DSA–positive and HLA-DSA–negative biopsy specimens with ABMR histology displayed similar upregulation of pathways and enrichment of infiltrating leukocytes. Transcriptional heterogeneity observed in biopsy specimens with ABMR histology was not associated with HLA-DSA status but was caused by concomitant T cell–mediated rejection. Compared with cases lacking ABMR histology, those with ABMR histology and HLA-DSA had higher allograft failure risk (hazard ratio [HR], 7.24; 95% confidence interval [95% CI], 3.04 to 17.20) than cases without HLA-DSA (HR, 2.33; 95% CI, 0.85 to 6.33), despite the absence of transcriptional differences.ConclusionsABMR histology corresponds to a robust intragraft transcriptional signature, irrespective of HLA-DSA status. Outcome after ABMR histology is not solely determined by the histomolecular presentation but is predicted by the underlying etiologic factor. It is important to consider this heterogeneity in further research and in treatment decisions for patients with ABMR histology.

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Thway, Khin, Jayson Wang, John Swansbury, Toon Min, and Cyril Fisher. "FluorescenceIn SituHybridization forMDM2Amplification as a Routine Ancillary Diagnostic Tool for Suspected Well-Differentiated and Dedifferentiated Liposarcomas: Experience at a Tertiary Center." Sarcoma 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/812089.

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Background. The assessment ofMDM2gene amplification by fluorescencein situhybridization (FISH) has become a routine ancillary tool for diagnosing atypical lipomatous tumor (ALT)/well-differentiated liposarcoma and dedifferentiated liposarcoma (WDL/DDL) in specialist sarcoma units. We describe our experience of its utility at our tertiary institute.Methods. All routine histology samples in whichMDM2amplification was assessed with FISH over a 2-year period were included, and FISH results were correlated with clinical and histologic findings.Results. 365 samples from 347 patients had FISH forMDM2gene amplification. 170 were positive (i.e., showedMDM2gene amplification), 192 were negative, and 3 were technically unsatisfactory. There were 122 histologically benign cases showing a histology:FISH concordance rate of 92.6%, 142 WDL/DDL (concordance 96.5%), and 34 cases histologically equivocal for WDL (concordance 50%). Of 64 spindle cell/pleomorphic neoplasms (in which DDL was a differential diagnosis), 21.9% showedMDM2amplification. Of the cases with discrepant histology and FISH, all but 3 had diagnoses amended following FISH results. For discrepancies of benign histology but positive FISH, lesions were on average larger, more frequently in “classical” (intra-abdominal or inguinal) sites for WDL/DDL and more frequently core biopsies. Discrepancies of malignant histology but negative FISH were smaller, less frequently in “classical” sites but again more frequently core biopsies.Conclusions. FISH has a high correlation rate with histology for cases with firm histologic diagnoses of lipoma or WDL/DDL. It is a useful ancillary diagnostic tool in histologically equivocal cases, particularly in WDL lacking significant histologic atypia or DDL without corresponding WDL component, especially in larger tumors, those from intra-abdominal or inguinal sites or core biopsies. There is a significant group of well-differentiated adipocytic neoplasms which are difficult to diagnose on morphology alone, in which FISH forMDM2amplification is diagnostically contributory.

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Waseem, Naureen, Aaqiba Rasheed, Maria Gill, Ayesha Asad, Muhammad Omar Shamim, and Fatima Waseem. "THE ATTITUDES OF MEDICAL STUDENTS TOWARDS CLINICAL RELEVANCE OF HISTOLOGY." PAFMJ 71, no. 1 (February 25, 2021): 351–56. http://dx.doi.org/10.51253/pafmj.v71i1.3756.

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Objective of Study: The objective of this study is to have an insight on student’s attitudes regarding histology’s clinical relevance in public and private sector medical college. Methodology: A cross sectional survey for attitude analysis towards histology’s clinical importance was carried out among 200 third year medical students from private and public sector medical college. Thurdstone and Chave attitude analysis questionnaire was employed to find the attitude score. Results: Students of both public and private sector medical college show scepticism towards the clinical importance of histology. There was no marked difference in the attitudes of students of public and private sector medical college. Most data remained on the borderline of the attitude scale employed. Conclusion: This study provided useful information for the teachers that students do not appreciate the clinical importance of histology much. Teachers need to devise strategies and to work on the students helping them comprehend the importance of histology.

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Napolitano, Larry, and David Crowe. "Pigmented Mammary Paget Disease Mimicking Superficial Spreading Melanoma in an Elderly African-American Female." Journal of Cutaneous Medicine and Surgery 19, no. 3 (March 13, 2015): 313–16. http://dx.doi.org/10.2310/7750.2014.14098.

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Background Pigmented mammary Paget disease (PMPD) is a rare disease that may mimic cutaneous melanoma both in clinical presentation and on histology. Objective The goal of this study was to discuss the clinical and histologic similarities between PMPD and cutaneous melanoma and how to differentiate between the two diseases. Methods We describe an African-American patient with PMPD who was thought to have cutaneous melanoma on presentation. We describe the similarities of PMPD to cutaneous melanoma both clinically and on histology and discuss the methods of differentiation. Results Clinical examination revealed a large pigmented patch of the left breast that appeared asymmetrical with irregular borders with a highly variable color pattern throughout. Histologic evaluation showed characteristics shared between PMPD and cutaneous melanoma. Immunohistochemical staining was needed for differentiation. Conclusion PMPD is a rare disease and is similar in clinical presentation and on histology to cutaneous melanoma. Immunohistochemical staining must be used to differentiate between the two diseases.

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Borteiro, Claudio, Francisco Kolenc, José Manuel Verdes, Claudio Martínez Debat, and Martín Ubilla. "Sensitivity of histology for the detection of the amphibian chytrid fungus Batrachochytrium dendrobatidis." Journal of Veterinary Diagnostic Investigation 31, no. 2 (January 19, 2019): 246–49. http://dx.doi.org/10.1177/1040638718816116.

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Histology is often underappreciated for the detection of the amphibian pathogenic fungus Batrachochytrium dendrobatidis, the cause of the potentially lethal skin disease chytridiomycosis. We evaluated the sensitivity of histology to detect chytrids in 20 wild specimens of 2 frog species from Uruguay that were clinically normal, but confirmed by PCR to be infected by B. dendrobatidis. We detected maturing and sporulated sporangia in 15 of 20 (75%) frogs, which is more sensitive than previously reported for histology. The effort needed to identify chytrids in histologic skin sections of Physalaemus henselii and Pleurodema bibroni required examination of 3.2 and 8.7 mm of skin sections for each frog species, respectively.

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Siegel, David A., Reda Wilson, Edward J. Wilkinson, Julia W. Gargano, Meg Watson, Brenda Y. Hernandez, Marc T. Goodman, Charles F. Lynch, Elizabeth R. Unger, and Mona Saraiya. "Evaluation of the Vulvar Cancer Histology Code Reported by Central Cancer Registries: Importance in Epidemiology." Archives of Pathology & Laboratory Medicine 141, no. 1 (October 20, 2016): 139–43. http://dx.doi.org/10.5858/arpa.2015-0422-oa.

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Context.—Knowing the subtype of vulvar cancer histology is important for estimating human papillomavirus–related cancer etiology. Surveillance of human papillomavirus–related vulvar cancers informs public health decisions related to vaccination against human papillomavirus. Objective.—To assess the accuracy of registry classifications of vulvar cancer and determine the histologic classification of cases reported as not otherwise specified. Design.—Pathology specimens were collected from Florida, Iowa, and Hawaii cancer registries. Registry diagnosis was compared with the pathology report from the medical record and a single expert study histology review of a representative histologic section from each case. Results.—The study included 60 invasive vulvar squamous cell carcinoma (SCC) cases, 6 Paget disease cases, 2 basal cell carcinoma cases, and 53 in situ cases. Comparing subtypes of invasive vulvar SCC, the registry agreed with the pathology report classification in 49 of 60 cases (81.7%). Study histology review identified the same SCC subtype as the registry in 9 of 60 cases (15.0%) and the same SCC subtype as the pathology report in 11 of 60 cases (18.3%). Whereas the registry and pathology reports classified 37 and 34 cases, respectively, as being SCC not otherwise specified, the study histology review identified a more specific subtype in all cases. Conclusions.—Subtypes of vulvar cancer were frequently recorded as not otherwise specified in the cancer registry primarily because the pathology report often did not specify the histologic subtype. Vulvar cancer registry data are useful for tracking broad diagnostic categories, but are less reliable for vulvar cancer subtypes.

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Lichte, V., H. Breuninger, G. Metzler, H. M. Haefner, and M. Moehrle. "Acral lentiginous melanoma: conventional histology vs. three-dimensional histology." British Journal of Dermatology 160, no. 3 (March 2009): 591–99. http://dx.doi.org/10.1111/j.1365-2133.2008.08954.x.

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Eszlinger, Markus, Knut Krohn, Steffen Hauptmann, Henning Dralle, Thomas J. Giordano, and Ralf Paschke. "Perspectives for Improved and More Accurate Classification of Thyroid Epithelial Tumors." Journal of Clinical Endocrinology & Metabolism 93, no. 9 (September 1, 2008): 3286–94. http://dx.doi.org/10.1210/jc.2008-0201.

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Context: Histologic examination of thyroid nodules is the current standard to distinguish benign from malignant thyroid epithelial tumors and to classify histologic subtypes. This review analyzes the problems in histological differential diagnosis as well as contradictions between histology and molecular data and describes possibilities to combine histology with molecular data in an effort to more accurately classify thyroid epithelial tumors. Evidence Acquisition: Published literature, addressing the current recommendations for thyroid tumor classification, as well as literature on the application of histology and molecular studies on the etiology of thyroid tumors is analyzed. Evidence Synthesis: The current histologic criteria to classify thyroid tumors, especially follicular-patterned tumors, are hampered by considerable interobserver variability. The detection of somatic mutations via genotyping and the definition of potentially informative gene expression signatures by microarray analyses, which can distinguish cancer subtypes as well as low- and high-risk cohorts, have recently demonstrated significant diagnostic potential. Moreover, in a routine diagnostic setting, micro-RNA profiling appears most promising due to their relative stability and the high accuracy of their expression profiles. Conclusions: It is very likely that molecular definitions of thyroid tumors mentioned in the current World Health Organization classification will be further developed, leading to future progress in defining thyroid tumor types by an integrated histologic and molecular approach. These integrated classifications need to be evaluated for their specific impact on thyroid tumor diagnosis and prognosis.