Дисертації з теми "Hip injury"
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Heath, Douglas. "Factors Affecting Occupant Risk of Knee-Thigh-Hip Injury in Frontal Vehicle Collisions." Digital WPI, 2010. https://digitalcommons.wpi.edu/etd-theses/422.
Повний текст джерелаWilcox, Christopher Richard James. "The development and implementation of a hip injury screening protocol within elite ice hockey." Thesis, University of Hull, 2015. http://hydra.hull.ac.uk/resources/hull:13607.
Повний текст джерелаReynolds, Abby Mae. "The Relationship of Static and Dynamic Hip Muscle Activation on Running Related Injury Rates in Recreational Runners." Thesis, North Dakota State University, 2016. https://hdl.handle.net/10365/28015.
Повний текст джерелаMark Knutson with the Fargo Marathon and the Post-Professional Athletic Training program at North Dakota State University
Harrison, Kathryn. "THE INFLUENCE OF TRAINING ON KINEMATICS RELATED TO KNEE INJURY IN NOVICE RUNNERS." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/6076.
Повний текст джерелаPeel, Nancye M. "The protective effect of healthy ageing on the risk of fall-related hip fracture injury in older people /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19388.pdf.
Повний текст джерелаDall, Philippa Margaret. "The function of orthotic hip and knee joints during gait for individuals with thoracic level spinal cord injury." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401337.
Повний текст джерелаKinder, Jessica Marie. "The Relationship of Hip Muscle Activation and the Incidence of Shoulder Injury in Collegiate Women's Volleyball Athletes: A Pilot Study." Thesis, North Dakota State University, 2018. https://hdl.handle.net/10365/28776.
Повний текст джерелаOlsson, Anna. "Prevention av ljumsksmärta hos herrfotbollsspelare - en möjlighet med enkla medel? : En kvantitav studie i 14 herrfotbollslag." Thesis, Linnéuniversitetet, Institutionen för idrottsvetenskap (ID), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-35912.
Повний текст джерелаBackground:Groin injuries, groin pain and hip pain for soccer players are often associated with decreased range of motion (ROM) in the hip, weakness in abdominal muscles and poor hip muscles. The risk of groinpain increases for athletes who do not practice any preventing exercises. Objective:To research if an injury prevention program with six exercises for strength and mobility has any effect on groin pain and hip pain for male soccer players. Measures and Methods: Quantitative experimental study with control group. 14 male soccer teams participated (7 teams in intervention group, 7 teams in control group). In the study 514 male soccer players participated, in the age of 15-47 years. Result: In the intervention group who practiced the prevention program did not the number of players with groinpain increased, compared with the control group where the numbers of players with grioinpain increased. Conclusion: An injury prevention program for male soccer players with exercises for strength and mobility could prevent increase of groinpain among male soccer players. Keywords: Soccer, prevention, groin injury, groin pain, hip pain
Chang, Sarah Randall. "A Comprehensive Strategy for Controlling the Hip and Knee with a Muscle-Driven Exoskeleton for Mobility after Paraplegia." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1481151499958917.
Повний текст джерелаHopkins, Susan Jane. "Disuse osteopenia : the short- and long-term effects of post-traumatic and post-surgical immobilisation following lower limb injury or total knee replacement." Thesis, University of Exeter, 2013. http://hdl.handle.net/10871/13721.
Повний текст джерелаHailer, Yasmin D. "Legg-Calvé-Perthes Disease – Is it just the hip? : Epidemiological, Clinical and Psychosocial Studies with special focus on Etiology." Doctoral thesis, Uppsala universitet, Ortopedi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-219158.
Повний текст джерелаGustavsson, Johanna. "Fallolyckor och höftfrakturer i Svenska kommungrupper." Thesis, Karlstad University, Faculty of Social and Life Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-4647.
Повний текст джерелаTimms, Stephen Allan. "The 3D kinematics of the single leg flat and decline squat." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/53119/1/Stephen_Timms_Thesis.pdf.
Повний текст джерелаLopes, Junior Osmar Valadão. "Avaliação da articulação coxofemoral ipsilateral em indivíduos do sexo masculino com ruptura do ligamento cruzado anterior com e sem contato físico." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/88429.
Повний текст джерелаObjective: To evaluate the range of motion (ROM) of the hip in patients who suffered contact anterior cruciate ligament (ACL) injury and compare it to patients with non-contact ACL injury. To performe a hip radiographic analysis of all subjects included. Method: ROM of the hip was evaluated in 35 patients with contact ACL injury (contact group) and compared to that of 45 patients who suffered a non-contact ACL injury (non-contact group). The sum of hip rotation (IR+ER) was also assessed according to the cutoff points of 70° and 80°. Radiographic hip were performed to assess the presence of deformity cam and pincer type. Results: ROM of the hip was statistically higher in the patients with contact ACL injury. The average sum of hip rotation was 66.1° ± 8.4° in non-contact group compared to 79.4° ± 10.6° in contact group (p<0.001). Seventy-seven percent of patients in non-contact group had a sum of hip rotation less than 70° and 93% had less than 80°, repectivally, compared to 17.1% and 42.9% in the contact group (p<0.001). The prevalence of cam or pincer deformity was similar between groups. Cam or pincer deformity was not more frequent in patients with limited range of motion of the hip. Conclusion: In our study, patients with contact ACL injury had greater range of motion of the hip than patients that suffered non-contact ACL injury. The presence of deformity cam or pincer was similar in both groups and was not related to a decreased range of motion of the hip.
Corletto, Federico. "Role of the HIF system in brain injury." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609260.
Повний текст джерелаMacDuff, Andrew. "Role of myeloid Hif-1α in acute lung injury". Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5581.
Повний текст джерелаVan, den Berg Julie. "Healing and functional outcomes after obstetric anal sphincter injury in HIV positive vs HIV negative patients." Master's thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/3055.
Повний текст джерелаIncludes bibliographical references (leaves 64-71).
Aim: To determine whether HIV-positive patients have a longer time to healing, more complications and poorer functional outcomes after Obstetric Anal Sphincter Injury (OASI) than an HIV-negative control group.
Huebenthal, Jan. "Injury & Resistance: Centering HIV/AIDS Histories in Times of Queer Equality." W&M ScholarWorks, 2019. https://scholarworks.wm.edu/etd/1563898925.
Повний текст джерелаWeir, Angela E. "Changing lives, the impact of a child's brain injury on his/her siblings." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0020/MQ47155.pdf.
Повний текст джерелаEsteve, Caupena Ernest. "Groin problems in male football: beyond the time-loss approach." Doctoral thesis, Universitat de Girona, 2020. http://hdl.handle.net/10803/671198.
Повний текст джерелаAquesta Tesi va tenir com a objectiu l'estudi de la prevalença i la severitat, i l’exemplar coneixement sobre l’etiologia i factors de risc de les lesions de l'engonal en futbolistes. Els quatre articles que formen la tesi estan basats en el mateix projecte de recerca, conduit en una cohort de futbolistes amateurs Espanyols. El dolor inguinal en la temporada passada, la força d'adductors, juntament amb dades demogràfiques i antropomètriques es van recollir a la pre-temporada. La funció esportiva relacionada amb el maluc i l'engonal es va registrar a l'inici de l'estudi i també durant la temporada cada quatre setmanes utilitzant el qüestionari Hip And Groin Outcome Score (HAGOS). Les lesions de l'engonal amb "time-loss", registrades pels fisioterapeutes dels equips, el dolor de l'engonal autoreportat i irrespectiu de "time-loss" es van registrar durant 44 setmanes per documentar tots els problemes de l'engonal, i problemes amb i sense "time-loss"
Davis, Laurie Michelle Helene. "THE UNDERLYING MECHANISM(S) OF FASTING INDUCED NEUROPROTECTION AFTER MODERATE TRAUMATIC BRAIN INJURY." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/673.
Повний текст джерелаKerrigan, Michael V. "Evaluation of advanced materials to protect against fall-related head injuries." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0003103.
Повний текст джерелаPukenytė, Evelina. "Veiksniai, sąlygojantys vaistų nuo tuberkuliozės sukeliamą kepenų pažeidimą, gydant živ infekuotus ir neinfekuotus aktyvia tuberkulioze sergančius pacientus." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2008. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2007~D_20080129_145950-51261.
Повний текст джерелаAlthough there are many hepatotoxicity risk factors describe for patients on antituberculosis therapy. However, the risk factors for liver injury and its occurence during this antituberculosis therapy have been assessed in HIV non-infected patients, they have rarely been assessed in HIV-infected patients, especially those treated for active tuberculosis. Most studies with HIV-infected patients on antituberculosis therapy have been carried out with a small amount of HIV-infected patients and results received are different. Aims and objectives The aim of this study is therefore to evaluate the incidence of severe liver injury in HIV-infected and non-infected patients on antituberculosis therapy, the time to its occurrence, and the clinical, biological and therapeutic risk factors for this injury. The objectives were as follows: 1. To investigate into demographic, clinical particularities and laboratory data of patients on antituberculosis treatment. 2. To define and compare the incidence of severe liver injury as well as the time of these occurrence in HIV-infected and non-infected patients on antituberculosis treatment. 3. To define and compare demographic, biological and clinical risk factors for severe liver injury in HIV-infected and non-infected patients on antituberculosis treatment within the first two month of this therapy. 4. To define the impact on liver injury occurrence of medications used in the first week of the tuberculosis treatment.
Kieser-Muller, Christel. "Needle stick injury and the personal experience of health care workers." Diss., Pretoria : [s.n.], 2005. http://upetd.up.ac.za/thesis/available/etd-01302006-144425.
Повний текст джерелаHamborg, Inger Helene. "High-level mobility in adults with traumatic brain injury and adults bom with very low birth weight." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for bevegelsesvitenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-17484.
Повний текст джерелаBartsch, Adam Jesse. "Biomechanical Engineering Analyses of Head and Spine Impact Injury Risk via Experimentation and Computational Simulation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1291318455.
Повний текст джерелаCirera, Eva. "Evolució de les lesions en la gent gran. Espanya 2000-2010." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/294997.
Повний текст джерелаTraumatic injuries in older people are a major public health problem, since they are one of the leading causes of morbidity in this age group. Studies of the incidence of injury and it trends among older people provide only a partial insight into the situation, since in most cases the data are limited to a single injury mechanism, such as the evolution of fall-related injuries, to specific injury types, such as hip fractures, or to injuries of a certain severity, such as those requiring hospitalization. The objectives of this thesis are to estimate the incidence of traumatic injuries among elderly individuals that were attended at hospitals in Spain, stratified by sex and age, as well as by severity and mechanism of injury. We also identify the most common injuries in older people, and finally analyse the evolution of their incidence over a period of eleven years. We conducted a descriptive study, using a cross-sectional or longitudinal design, depending on the objectives. The population study consists of individuals over 64 years of age who were resident in Spain between 2000 and 2010. Incidence rates were calculated using data provided by the National Hospital Discharge Register (NHDR) from the Spanish Institute of Health Information (Ministerio de Sanidad, Servicios Sociales e Igualdad), and the National Institute of Statistics. Cases were Spanish residents older than 64 years discharged from a Spanish hospital with a primary diagnosis of traumatic injury. Incidence trends were analysed using generalized linear models, assuming Poisson distribution and log link function for each dependent variable, and adjusting for overdispersion. The Annual Percent Change (APC) of the rate is computed from the estimated relative risk (RR) and its 95% confidence interval. The incidence of traumatic injuries attended at hospital is higher among women than men, and increases with age. A positive trend in incidence has been observed in recent years, especially in individuals over 75-80 years of age, and this increase is accentuated by age. Traffic injuries are the only injury type in which we observe a decline. Hip fractures are still the most common injury type, although in the case of individuals under 75 years, their incidence decreased significantly in women and remained stable in men throughout the study period. The effect of this decline has been counterbalanced by an increase in the incidence of other types of injury such as head injuries and fractures in the upper extremities. The results of this thesis allow us to identify two large groups within the population of older people, the elderly (up to 75-80 years) and the super-elderly (from this age onward). While hip fractures remain the most common injury type in all age groups, their decrease in incidence among elderly women along with the increase in frequency of fractures of the upper extremities and of traumatic brain injuries means that hip fractures are losing importance in this age group. In the case of super-elderly individuals, the increase
Lloyd, Jacobus. "Behavioural and protective factors contributing to the risk and vulnerability to HIV/AIDS among individuals with spinal cord injuries in South Africa." University of the Western Cape, 2019. http://hdl.handle.net/11394/7025.
Повний текст джерелаHIV/AIDS has made a huge impact on human development and sexual reproductive habits in this century in the world and especially in sub-Saharan Africa. It has only recently been acknowledged that HIV/AIDS has an equal if not greater effect on or threat to people with disabilities. Survivors of traumatic spinal cord injury (TSCI) with resultant disability are incorrectly believed to be sexually inactive, unlikely to use drugs or alcohol and at less risk of violence or rape than their non-disabled peers. This group can thus be described as economically, educationally and socially disadvantaged, which in itself, suggest that they are a high-risk group for HIV infection. The overall aim of this study is to examine the factors that could contribute to the risk and vulnerability to HIV/AIDS among individuals with spinal cord injuries in South Africa. The specific objectives of the study are to assess the behavioral and protective factors that could contribute to risk and vulnerability to HIV infection among individuals and spinal cord injuries; and to explore the socio-cultural issues that might increase individuals with spinal cord injuries’ vulnerability to HIV/AIDS. The design of this study was a mixed methods design, particularly the sequential explanatory strategy was used will used in this study. The study was conducted in four (4) conveniently selected provinces (highest prevalence of SCI). The Quad-Para Association of South Africa’s (QASA) provincial databases was used to invite individuals with SCI to participate in the study. Data for quantitative part of the study was collected by means of self-administered questionnaires. The questionnaire consisted of various sections requesting for information on: Demographics; HIV-Knowledge (HIV- KQ-18); Sexual behaviours; Sexual communication and negotiation skills; Self-efficacy to refuse sex. Separate binary logistics analysis was done to assess which of the selected factors are associated with risky sexual behaviour. The forced entry method approach was used to determine which of these factors have the greatest productive power to predict sexual risk behaviour. No “a priori” sample size was developed for the qualitative part, but participants were recruited until saturation has been reached of all the categories. Consenting participants were visited by the researcher for data collection in the environment indicated by the participant. Permission to conduct the study was obtained from the Research Ethics Committee at the University of the Western Cape (UWC). The study was conducted according to ethical practices pertaining to the study of human subjects as specified by the UWC and Faculty of Community and Health Sciences Research Ethics Committee of the UWC.
Anjos, Carlos Frederico Dantas. "Ventilação mecânica não invasiva com pressão positiva em vias aéreas, em pacientes HIV/AIDS com lesão pulmonar aguda e insuficiência respiratória: estudo de avaliação do melhor valor de PEEP." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5167/tde-09112011-134108/.
Повний текст джерелаINTRODUTION: The acquired immunodeficiency syndrome (AIDS) is a pandemic, and lung diseases are the leading cause of morbidity and mortality and are often associated with respiratory infections, hypoxemia and death. The noninvasive ventilation with positive pressure refers to the provision of mechanical ventilatory assistance without the need for artificial airway invasion, being recognized for improving oxygenation and dyspnea in patients with hipoxemic respiratory failure. Patients with AIDS and hypoxemic respiratory failure often require invasive mechanical ventilation, which is independently associated with mortality. Given the uncertainties about response in oxygenation with PEEP in patients with AIDS with acute hypoxemic respiratory failure and using the rational for progressive pressurization of the airway and its potential benefits on blood oxygenation, we made the hypothesis that increased levels of sequential PEEP up to 15 cmH2O may improve blood oxygenation without affecting the comfort and hemodynamics of the patient. The main objective of this study was to investigate the effects of different sequences of PEEP levels on gas exchange, the sensation of dyspnea and hemodynamics in patients with AIDS and acute hypoxemic respiratory failure. The secondary objective was to assess the time free of invasive mechanical ventilation in 28 days and hospital mortality within 60 days. METHODS: We studied 30 adults patients with HIV/AIDS and acute hypoxemic respiratory failure. All patients received a randomized sequence of noninvasive PEEP (the values used were 5,10 or 15 cmH2O) for twenty minutes. PEEP was delivered via face mask with pressure support (PSV) of 5 cmH2O and FiO2 = 1. A washout period of 20 minutes with spontaneous breathing was allowed between each PEEP trial. Clinical variables and arterial blood gases were recorded after each PEEP step. RESULTS: Analyzing the 30 patients, oxygenation improved linearly with increasing PEEP, however studying the patients randomized according to the initial PEEP, oxygenation was similar regardless of the first randomized PEEP (5,10 or 15 cmH2O), and only the subgroup with initial PEEP = 5 cmH2O further improve the oxygenation when high PEEP were used. The PaCO2 also rose beside the PEEP elevation, especially with a PEEP = 15 cmH2O. The use of PSV = 5 cmH2O was associated with significant and consistent improvement of subjective sensation of dyspnea and respiratory rate with a PEEP from 0 to 15 cmH2O. CONCLUSION: AIDS-patients with hypoxemic respiratory failure improve oxygenation with a progressive sequential elevation of PEEP up to 15 cmH2O, however the elevation of PaCO2 limit the PEEP up to 10 cmH2O. A PSV = 5 cmH2O promotes an improvement of subjective sensation of dyspnea independently from the use of PEEP
Soares, Alexandre Learth. "Instilação nasal de LPS ou suco gástrico como fator exacerbador da inflamação pulmonar ocasionada pela isquemia e reperfusão intestinal em camundongos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-06102009-151646/.
Повний текст джерелаIntestinal ischemia and reperfusion (I/R) is implicated as a prime initiating event in the development of systemic inflammatory syndrome and Acute Respiratory Distress Syndrome (ARDS). Several studies pointed the possibility of massive systemic inflammatory events rendering the lungs more susceptible to an exacerbated inflammatory response, the so called two-hit hypothesis. In this way, minor local inflammatory stimuli could be a trigger for ARDS. In this study we investigated the effects of low-dose LPS or gastric juice (GJ) administered by nasal instillation to mice previously submitted to intestinal I/R. Our data showed that i-I/R alone induced histological signs of edema in lung as well as an increase of lung MPO activity and IL-6, G-CSF, KC, IP-10 and MCP-1 levels. Nasal instillation of LPS following i-I/R increased lung MPO activity and exacerbated lung vascular permeability. In this case, aminoguanidine or vinblastine blocked the increase of vascular permeability, suggesting the role of neutrophils and nitric oxide in injury induced by the two-hit stimuli. Instillation of GJ induced an initial (2h) increase of lung MPO followed by the influx of neutrophils (24h) to the alveolar space. Such process was followed by the transient expression of TNF-a in BAL and balanced by IL-10. The exacerbated inflammatory response of IL-10 KO mice to GJ instillation shows the importance of this cytokine in the control of the inflammation in such model. Treatment with rolipram or PKF 241-466 compound (TNF-a inhibitors) reduced lung inflammation induced by GJ. Nasal instillation of GJ after i-I/R exacerbated the increase in lung vascular permeability. The data shown suggest that the exposition of the organism to mesenteric trauma primes the host organism to a secondary inflammatory stimulus such as LPS or gastric juice. Considering the possible multiple insults to lung to which patients in intensive care units are submitted, the results of this study might contribute to the understanding of the regulatory mechanisms of neutrophils and generation of inflammatory mediators in the context of ARDS.
Blom, Malin. "Vägen till 2.0 : Att hantera en allvarlig hjärnskada." Thesis, Konstfack, Institutionen för design, inredningsarkitektur och visuell kommunikation (DIV), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:konstfack:diva-6307.
Повний текст джерелаMy master project is a book that aims to support relatives of people with aquired brain injuries, where I use myself and my own rehabilitetion after a hit-and-run accident as a case study.
Ralaidovy, Ambinintsoa Haritiana. "Efficiency in health ressource allocation : three empirical studies in Eastern Sub-Sahara Africa and Southeast Asia." Thesis, Université Clermont Auvergne (2017-2020), 2019. http://www.theses.fr/2019CLFAD016.
Повний текст джерелаPriority setting in health, in the context of Universal Health Coverage, emphasizes three values: improving population health, ensuring equity in access to and quality of services and avoiding impoverishment or underutilization of services as a result of out-of-pocket expenditures. Allocative efficiency can be measured with respect to any one of these values, or with respect to all together by different variants of Cost-Effectiveness Analysis. In this thesis, we use the Generalized Cost-Effectiveness Analysis, a standardized approach developed by the World Health Organization’s programme, ‘Choosing Interventions that are Cost-Effective’ (WHO-CHOICE) that can be applied to all interventions in different settings. This thesis provides a quantitative assessment of allocative efficiency within three health categories: communicable diseases, noncommunicable diseases, and road traffic injuries, focusing on two economically and epidemiologically diverse regions: Eastern sub-Saharan Africa and Southeast Asia. Our objectives are to inform health policy debates, improve the world’s body of knowledge on the cost-effectiveness of different interventions by providing more information on the allocative efficiency in those three disease groups and contribute to discussions on Universal Health Care packages
Liu, Chi-Tzu, and 劉紀慈. "Effectiveness of hip motor control training in young dancers with ankle-foot injury." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/227rc4.
Повний текст джерела國立陽明大學
物理治療暨輔助科技學系
106
INTRODUCTION: Ballet movement requires a great movement range and control of the hip joint. It has been shown that hip joint control bears an important role in balance strategy, and is associated with lower extremity injuries. Past studies mentioned that subjects with insufficient hip muscle strength had a higher risk of ankle sprain during landing. Researchers showed hip strengthening program could improve lower extremity neuromuscular control in patients with chronic ankle instability. However, few studies have assessed the differences in hip musculoskeletal characteristics between the injured dancers and healthy dancers, and the effectiveness of hip motor control training in dancers with ankle-foot injury. Therefore, aim of this study was to compare the hip musculoskeletal characteristics between the dancers, and to determine the the effectiveness of hip motor control training on lower extremity muscle performance. METHODS: First, we recruited 33 young dancers with ankle-foot injury (7 males and 26 females, 19.34±2.35 years old) and 12 healthy dancers (2 males and 10 females, 18.33±2.61 years olf). All participants received the measurement of muscle activation (gluteus maximus, gluteus medius, biceps femoris, femoris rectus, tibialis anterior, peroneal longus and soleus), lower extremities muscle length and muscle strength. The Multivariate Analysis of Variance (MANOVA) was used to statistically compare differences in lower extremity musculoskeletal control characteristics between the injured group and healthy group. Subjects in the injured group were then randomized to either the hip motor control training group (experimental group, 3 males and 13 females, 19.24±3.03 years old, n=16) or the control group (4 males and 13 females, 19.45±1.41 years old, n=17) and received hip motor control training for 4 weeks. The outcome measures as well as lower extremity muscle strength (pound/body mass), muscle length (degree), compensated turnout, muscle activation (%MVC) were measured before and after intervention. Injury rate was measured 6 months after the intervention. Two-way repeated measures analysis of variances (ANOVAs) and Two-way repeated measures analysis of covariances (ANCOVAs) were used to examine if the experimental group improved more than the control group after intervention. A statistical significance was set at P < 0.05. RESULTS AND DISCUSSION: Injured group demonstrated higher compensated turnout (47.36±13.18 vs. 36.29±12.62, p=0.019), lower gluteus maximum muscle activation (34.13±9.83 vs. 39.26±11.09 vs. 41.35±7.56, p=0.046) as compared to the healthy group. And hip motor control training group resulted in significantly better improved in lower extremity muscle strength (affected side hip abductors, hip adductors, hip internal rotators, ankle dorsiflexors and non-affected side hip abductors, hip external rotators, hip internal rotators, knee flexors, ankle evertors, ankle invertors, ankle dorsiflexors), affected side calf muscle length, muscle activation during jump landing (affected side femoris rectus, 45.13±18.14 and 50.13±14.88 vs. 47.62±12.15 and 51.52±10.16, p=0.026) as compared to the control group after 4-week intervention. CONCLUSIONS: Young dancers with ankle-foot injury showed bigger compensated turnout angle and lower gluteus maximus muscle activation as compared to the healthy group. Hip motor control training was effective in improving lower extremity muscle strength and affected-side calf muscle length improvement.
Levine, Iris Claire. "The Effects of Body Mass Index and Gender on Pelvic Stiffness and Peak Impact Force During Lateral Falls." Thesis, 2011. http://hdl.handle.net/10012/6287.
Повний текст джерелаKit, Alanna Katharine. "A feasibility study to test the potential efficacy of a rowing-related yoga program on male varsity competitive rowers." Thesis, 2020. http://hdl.handle.net/1828/11740.
Повний текст джерелаGraduate
2021-04-06
Gustavsson, Johanna. Thesis, Karlstads universitet, Fakulteten för samhälls- och livsvetenskaper, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-4647.
Повний текст джерелаSeedat, Faheem. "Renal impairment in HIV infected patients receiving tenofovir-based antiretroviral therapy in a South African hospital." Thesis, 2017. http://hdl.handle.net/10539/23269.
Повний текст джерелаObjective: There is limited data describing acute kidney injury (AKI) in HIV-infected adult patients in resource-limited settings where increasingly, tenofovir (TDF), which is potentially nephrotoxic, is prescribed. We describe risk factors for, and prognosis of AKI in HIV-infected individuals receiving and naïve to TDF. Methods: This was a prospective case cohort study of hospitalized HIV-infected adults with AKI (as defined by the 2012 KDIGO Clinical Practice Guideline for AKI) stratified by TDF exposure. Adults (≥18 years) were recruited: clinical and biochemical data was collected at admission; their renal recovery, discharge or mortality was ascertained as an in-patient and, subsequently, to a scheduled 3-month follow-up. Results: Amongst this predominantly female (61%), almost exclusively black African cohort of 175 patients with AKI, 93 (53%) were TDF exposed; median age was 41 years (IQR 35-50). Median CD4 count and VL and creatinine at baseline was 116 cells/mm3 and 110159 copies/ml, respectively. A greater proportion of the TDF group had severe AKI on admission (61% v 43% p=0.014); however, both groups had similar rates of newly diagnosed tuberculosis (TB) (52%) and NSAID (32%) use. Intravenous fluid was the therapeutic mainstay; only 7 were dialyzed. Discharge median serum creatinine (SCr) was higher in the TDF group (p=0.032) and fewer in the TDF group recovered renal function after 3-months (p=0.043). 3-month mortality was 27% in both groups but 55% of deaths occurred in hospital. Those that died had a higher SCr and more severe AKI than survivors; TB was diagnosed in 33 (70%) of those who died. Conclusions: AKI was more severe and renal recovery slower in the TDF group; comorbidities, risk factors and prognosis were similar regardless of TDF exposure. Because TB is linked to higher mortality, TB co-infection in HIV-infected patients with AKI warrants more intensive monitoring. In all those with poor renal recovery, our data suggests that a lower threshold for dialysis is needed.
MT2017
Brilha, Sara Sofia dos Santos 1985. "Strategies for early detection of renal injury in HIV-infected patients : the new troponin." Master's thesis, 2011. http://hdl.handle.net/10451/4179.
Повний текст джерелаBackground: HIV-infected patients have a known increased risk of kidney disease. For that reason, a biomarker that enables reliable detection of early and mild kidney dysfunction would be advantageous. Cystatin C is considered to be a better marker of kidney function than creatinine. Objectives: This study aimed to evaluate if serum cystatin C was a better marker than creatinine in a HIV-infected population. Material and Methods: This was an observational study of HIV-infected patients that attend the Infectious Diseases Department, at the Hospital Santa Maria, Lisbon. Patients with known kidney disease or HIV-2 infection were excluded. Clinical and demographic data was recorded and serum creatinine and cystatin C levels were determined. Results: A total of 242 patients were included. Cystatin C is an independent factor of age, gender, ethnicity and body mass index. Of the 17 patients with elevated levels of cystatin C but with an estimated creatinine clearance within normal range, 11 were on antiretroviral therapy with tenofovir and/or atazanavir. Fourteen patients were smokers and 10 patients had hepatitis C virus co-infection, which are known causes of inflammation. In a matched control group of 27 patients, with cystatin C within normal range, the majority of patients also were on an antiretroviral regimen with tenofovir and/or atazanavir. However, none of them had hepatitis C virus co-infection. Moreover, a statistical association was found between high levels of cystatin C and alanine transaminase. Differences between biomarkers’ levels and patients on combinations with tenofovir, ritonavir boosted atazanavir or both were also studied. Although it was not found any statistically significant difference in creatinine and estimated creatinine clearance, with cystatin C, patients that were on atazanavir or tenofovir and had a higher level of cystatin C, compared with patients that never were on these drugs. Conclusion: Cystatin C levels may be increased in inflammatory conditions. Therefore, in HIV-infected patients, where chronic systemic inflammation is present, often associated to other inflammation sources, such as chronic hepatitis C virus co-infection, the use of cystatin C to monitor kidney function may overestimate kidney impairment. In what concerns to nephrotoxicity, it was found that patients on atazanavir had higher levels of cystatin C. It is important to develop prospective studies, in order to assess the real long-time impact of the more recent antiretroviral drugs on kidney function.
Introdução: Os doentes infectados por VIH possuem um risco aumentado para o desenvolvimento de doença renal. Por esta razão, seria importante utilizar um marcador que permitisse uma detecção precoce de alterações da função renal. A cistatina C tem sido referida na literatura como um melhor marcador da função renal, comparativamente com a creatinina. Objectivos: O objectivo deste estudo é analisar se a cistatina C sérica constitui um melhor marcador da função renal que a creatinina, para a população de doentes infectados por VIH. Material e métodos: Este é um estudo observacional de doentes infectados por VIH, seguidos no Serviço de Doenças Infecciosas do Hospital de Santa Maria, Lisboa. Os doentes com doença renal documentada e infecção por VIH-2 foram excluídos deste estudo. Foram recolhidos dados clínicos e demográficos e foram determinados os níveis séricos de creatinina e cistatina C. Resultados: Um total de 242 doentes foi incluído neste estudo. Os níveis de cistatina C mostraram-se independentes da idade, sexo, etnia e índice de massa corporal. Dos 17 doentes com níveis elevados de cistatina C mas com clearance da creatinina dentro dos valores de referência, 11 doentes estavam sob terapêutica antirretroviral com tenofovir e/ou atazanavir potenciado com ritonavir. Catorze doentes eram fumadores e 10 estavam co-infectados por vírus da hepatite C, que constitui um factor conhecido de inflamação. Num grupo controlo de 27 doentes, com cistatina C dentro dos valores normais, a maioria dos doentes também se encontrava sob terapêutica antirretroviral com tenofovir e/ou atazanavir. No entanto, nenhum possuía co-infecção por vírus da hepatite C. Foram também analisadas diferenças entre os níveis dos marcadores e doentes em combinações com tenofovir, atazanavir potenciado com ritonavir ou com ambos. Embora não tenha sido encontrada nenhuma diferença estatisticamente significativa nos níveis de creatinina e clearence da creatinina estimado, com a cistatina C, doentes sob atazanavir ou tenofovir e atazanavir possuíam níveis mais elevados deste marcador, comparativamente com os doentes que nunca estiveram sob estes antirretrovirais. Conclusão: Os níveis de cistatina C podem aumentar com factores inflamatórios. Por esta razão, no caso dos doentes infectados por VIH, onde existe uma inflamação sistémica crónica, muitas vezes associada a outras fontes de inflamação, como a co-infecção por vírus da hepatite C, a utilização exclusiva da cistatina C para a monitorização da função renal pode conduzir a uma sobrestimação de uma lesão renal. Em termos de nefrotoxicidade, verificou-se que doentes sob atazanavir possuíam níveis mais elevados de cistatina C. É de extrema importância, o desenvolvimento de novos estudos prospectivos, de forma a permitir a análise do impacto a longo prazo destes antirretrovirais mais recentes na função renal.
Shih, Hsin-Chin, and 施信嶔. "The Effect of Using Magnolol on Hemorrhagic Shock and Second-hit Injury in Rats." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/27699465787420841501.
Повний текст джерела國立陽明大學
臨床醫學研究所
94
Background: Systemic inflammatory response syndrome accompanying inflammatory cytokine response is evoked after severe injury in patients and frequently culminates in sepsis and multiple organ dysfunction. Involvement of cytokines, such as tumor necrosis factor- alpha (TNF-��) and interleukin-10 (IL-10) in inflammatory response, is related to oxidative stress. Ischemia-reperfusion following resuscitation from trauma and hemorrhagic shock primes the trauma victims for an exaggerated response to a second inflammatory stimulus, the so-called second hit. Hemorrhagic shock and fluid resuscitation (HS) can induce an unfavorable condition in animals and increase their mortality in subsequent sepsis. However, brief period of hemorrhagic shock in rats, so-called sublethal hemorrhage (SLH), can induce endotoxin tolerance and protect the animals from subsequent endotoxin challenge (EC). Both SLH and HS are associated with an initial surge of pro-inflammatory cytokines. Magnolol has been shown to be a potent antioxidant with anti-inflammatory effects. Our study was performed to test the hypothesis that magnolol could inhibit the initial pro-inflammatory cytokine response after HS or SLH and alter the outcome of the episode in subsequent second hit. Materials and methods: In the first two-hit model, intra-abdominal sepsis was performed following HS in rats. The rats were randomly segregated into one of three groups. Rats in control group rats were sham-operated. Rats in the untreated or treated group received HS and treatment with vehicle or magnolol, respectively; cecal ligation punctures were perfromed 24 hous later. In the second two-hit model, EC was performed following SLH in rats. Rats were randomly segregated into one of four groups. Rats in the Sham/Veh or Sham/Mag group received a sham operation for SLH and treatment with vehicle or magnolol, respectively. Rats in the SLH/Veh or SLH/Mag group received SLH and treatment with vehicle or magnolol, respectively. Animals were subjected to EC at 12, 24, or 36 h after these procedures. Plasma cytokine levels and tissue cytokine contents of lung, including TNF-�� and IL-10 were assayed. Pulmonary injury study was performed by using Evans blue dye method following sepsis. RT-PCR for cytokines, lipid peroxidation, and superoxide dismutase activity were measured in lung tissue following SLH. Survival analyses of rats were performed after sepsis or EC. Results: Plasma and tissue TNF-�� levels increased after HS or SLH. Magnolol treatment blunted the TNF-�� levels in plasma and tissue. Plasma IL-10 level increased after HS but not after SLH, whereas the tissue level of IL-10 did not change. Magnolol treatment significant increased tissue IL-10 level after HS or SLH. Lipid peroxidation and SOD activity increased after SLH; magnolol suppressed the lipid peroxidation but not the SOD activity. After sepsis or EC, TNF-�� levels significantly increased in both plasma and tissue. Magnolol-treated animals had significantly lower TNF-�� levels than those in untreated animals. Pulmonary injury study and survival analysis showed that magnolol-treated rats had decreased pulmonary injury and increased survival after sepsis. On the other hand, If EC was performed 12 or 24 h after SLH, greater survival with decreased TNF-�� and increased IL-10 in plasma was observed in the SLH/Mag group. If EC was performed 24 or 36 h after SLH, greater survival with decreased plasma TNF-�� was observed in the SLH/Veh group. Conclusion: This study reveals that magnolol modifies cytokine response and provides protection of the rats early after HS or SLH. However, magnolol attenuates the protraction of endotoxin tolerance and inhibits late protection against EC following SLH. Our results show that magnolol may provide early protection of animals following hemorrhagic shock.
Gojo, Mawande Khayalethu Edson. "Investigation of acute systemic inflammatory response and myocardial injury after cardiac surgery in patients infected with human immunodeficiency virus." Thesis, 2016. http://hdl.handle.net/10321/2577.
Повний текст джерелаIntroduction: The immediate post-cardiopulmonary bypass (CPB) immune responses and organ injuries in immune- compromised patients remain poorly documented. We conducted a prospective clinical study to determine whether or not human immunodeficiency virus (HIV) seropositive patients generate higher acute systemic inflammatory response and suffer greater myocardial injury, compared to HIV seronegative patients. Methodology: Sixty-one consecutive patients i.e. Thirty HIV seropositive patients and Thirty-one seronegative, undergoing elective cardiac valve(s) replacement were enrolled, over a period of nine months from a single center hospital, after informed consent was acquired. The C-reactive protein (CRP) and Erythrocyte sedimentation rate (ESR) were used as biomarkers of acute inflammatory response, and cardiac troponin I (cTnI) as a biomarker for measuring postoperative myocardial injury. Single tests were measured preoperatively and postoperatively, in both groups, and these were compared and correlated to perioperative events and CPB parameters. Results: The mean age group was similar between the HIV seropositive and negative group (37.8 and 37.1 years, respectively). Preoperatively both groups had relatively equal CRP levels (p=0.388), ESR levels (p=0.817) and cTnI (p=0.489). The CPB events and durations were significantly different between the two groups, CPB duration (p=0.021). Other CPB events include, clamp aortic duration (p=0.026), CPB blood transfusion (p=0.013), CPB total urine output (p=0.035) and CPB peak lactate (p=0.040). Postoperatively we observed significant increased biomarkers level in both groups, with no significant difference between the groups: mean CRP (p=0.115), mean ESR (p=0.214) and cTnI (p=0.363). We observed a significant negative correlation between the mean change in CRP levels and mechanical ventilation (r=- 0.548, p=0.002) in the seropositive group, but not in the uninfected group (r=0.025, p=0.893). The correlation between the difference in CRP and ICU stay was not significant between in both group (r=-0.231, p=0.229 and r=0.25, p=0.975, respectively). A significant positive correlation between postoperative cTnI and the inotropic support duration (r=0.384, p=0.040) was seen in the seropositive groups, but not in the negative group (r=0.092, p=0.622). Furthermore we observed a significant drop in CD4 cells postoperatively (p=<0.001) in the HIV seropositive group. Antiretroviral treatment appeared to influence the degree of change in CD4 cells postoperatively. Conclusion: We conclude that HIV positive patients’ postoperative reactions to cardiac surgery supported by CPB are similar to those of HIV seronegetive patients. We further report non-paralleling correlations between the biomarkers and perioperative events; however these do not seem to affect the overall outcomes between the two groups.
M
Hung, Chia-Yu, and 洪嘉鈺. "Using HAp as Bletilla striata polysaccharide carrier toprevent muscle injured by sarcopenia." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/cq2mka.
Повний текст джерела國立臺灣大學
醫學工程學研究所
105
Sarcopenia is a disease of muscle mass loss and muscle function decline caused by aging. Because there are no effective and no side effects treatments to treat sarcopenia, and hydroxyapatite is one of the components of bones and teeth in human body, has well biocompatibility and biodegradability. Not only can supplement the body of the lack of calcium in the body but also through the drug long-term Release to reduce the drug injection frequency, mitigate the pain suffered by the elderly. In this study, the starting point is that prevention is better than treatment . Inject HAp─BSP first then inject lipopoly- saccharide extracted from E.coli which is going to induce muscle injury and re- duction muscle mass that are similar to the symptoms of sarcopenia. To observe the difference between the experimental group and the control group (induced by LPS-induced muscle injury and inflammatory reaction), and to analyze the results of muscle tension test, muscle endurance test, blood analysis, HE stain and MRI image to find whether HAp─BSP can prevent muscle injury and anti-inflammatory. According to ISO-10993, HAp, BSP and HAp-BSP prepared in this experiment are biologically toxic and have good biocompatibility. Through the TGA analysis, HAp-BSP drug loading efficiency is about 13%, and the BSP volatilization at 300 oC, which is the same as the re- ference. In this study, we successfully used LPS to induce muscle injury that similar to sarcopenia, and HAp-BSP could prevent the symptoms caused by LPS. It was confirmed that HAp-BSP had its anti-oxidation and promoting tissue capacity.
CHEN, CHIA-YEN, and 陳家彥. "A Study on the「Resulting in Death or Injury」 of Hit and Run Offense Under Criminal Law and Other Concurrent Crime Issues." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/2n477k.
Повний текст джерела國立臺北大學
法律學系一般生組
102
Since legislators ordered the Criminal Code Article 185-4, the problem of interpretation of the provisions that began to appear. In a variety of controversial issues, the most discrepancies two parts of opinion among the scholars, the interpretation of「Resulting in Death or Injury」of Hit and Run Offense and Issues of the Criminal Code Article 294. For the former, the focus of the debate was that the「Resulting in Death or Injury」belonging to "illegal Elements," or are "objective penalties Conditions" .The problem with this argument is most directly related to the person in hit and run offense, whether the person should be aware of Killed or injured people in the accident. For the latter, the focus of debate in the hit and run offense is what the legal interest is. If Article 185-4 and Article 294 of the Criminal Code are to protect individual life, physical benefits, the judge should apply to the former; Conversely, if Article 185-4 of the Criminal Code is not the protection of personal life, physical benefits, but belongs the social legal interest, on the competing relationship, should be applicable to the latter. Therefore in research to protect the interests article 185-4 of the Criminal Code, We can understand How to apply the right article. Furthermore, in order to delineate the scope of punishment, this paper is to study the scope of the above two arguments and to read the various points of view, try to publish individual views. In addition, in order to grasp the Supreme Court for the crime of hit and run offense so far in the development and updating of changes on the legal opinions over the years, this paper will examine the legal opinion of the Supreme Court for the crime of hit and run offense and trying to assessment, in order to understand the application of the crime.
Haladuick, Tyler. "Numerical Simulation of Blast Interaction with the Human Body: Primary Blast Brain Injury Prediction." Thesis, 2014. http://hdl.handle.net/10012/8265.
Повний текст джерелаShen, Wen-Ching, та 沈紋君. "Endothelial progenitor cells derived from Wharton’s jelly of the umbilical cord reduces ischemia-induced hind limb injury in diabetic mice by inducing HIF-1α/IL-8 expression". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/485smp.
Повний текст джерела國立臺灣大學
解剖學暨細胞生物學研究所
101
Peripheral arterial diseases, the major complication of diabetes, can result in lower limb amputation. As endothelial progenitor cells (EPCs) are involved in neovascularization, the study was to examine whether EPCs isolated from Wharton’s jelly (WJ-EPCs) of the umbilical cord, a rich source of mesenchymal stem cells, could reduce ischemia-induced hind limb injury in diabetic mice. We evaluated the effects of WJ-EPC transplantation on hind limb injury caused by femoral artery ligation in mice with streptozotocin (STZ)-induced diabetes. We found that the ischemic hind limb in mice with streptozotocin-induced diabetes showed decreased blood flow and capillary density and increased cell apoptosis and that these effects were significantly inhibited by injection of WJ-EPCs. In addition, HIF-1α and IL-8 were highly expressed in transplanted WJ-EPCs in the ischemic skeletal tissues and were present at high levels in hypoxia-treated cultured WJ-EPCs. Moreover, incubation of the NOR skeletal muscle cell line under hypoxic conditions in conditioned medium from EPCs cultured for 16 h under hypoxic conditions resulted in decreased expression of pro-apoptotic proteins and increased expression of anti-apoptotic proteins. The inhibition of HIF-1α or IL-8 expression by EPCs using HIF-1α siRNA or IL-8 siRNA, respectively, prevented this change in expression of apoptotic-related proteins. Wharton’s jelly in the umbilical cord is a valuable source of EPCs and transplantation of these EPCs represents an innovative therapeutic strategy for treating diabetic ischemic tissues. The HIF-1α/IL-8 signalling pathway plays a critical role in the protective effects of EPCs in the ischemic hind limb of diabetic mice.
Chang, Pei-Lin, та 張佩琳. "The Effects of Low-Level Laser Therapy on Recovery of Neuropathic Pain and Neural Function -Possible Involvement of HIF-1α in Rats with Chronic Constriction Injury of the Sciatic Nerve". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/54720111664521388621.
Повний текст джерела中國醫藥大學
物理治療學系復健科學碩士班
99
Background Peripheral nerve injury may induce nerve inflammation and neuropathic pain,and these phenomena not only cause physical and psychological discomfort of patients, but may also indirectly affect their quality of life. Low-energy laser treatment (low level laser therapy, LLLT) is often used to reduce pain, inflammation, wound healing and to help accelerate tissue regeneration, but the literatures and studies concerned about the therapeutic effects on the peripheral nerve injury and the molecular biological mechanism of LLLT were very few. In addition, in recent years, many researches explored that hypoxia inducible factor-1α (HIF-1α) involves in the process of inflammation, but its role and mechanism in regulation of peripheral nerve injury-induced inflammation was still not clear. Therefore, the animal model of sciatic chronic constriction injury (CCI) was used in this study for investigating the effects of LLLT on neuropathic pain and functional recovery. Purpose The purposes of this study were to assess the suppressive effects of LLLT on nerve function, accumulation of hypoxia-inducible factor-1 alpha (HIF-1α), proinflammatory cytokines interleukin-1β (IL-1β), tumor necrosis factorα (TNF-α) , inducible nitric oxide syntheses (iNOS), cyclooxygenase enzymes-2 (COX-2), tumor suppressor protein p53 (p53) and macrophages for controlling neuropathic pain after peripheral injury. Moreover, the effects of LLLT on activation of vascular endothelial growth factor (VEGF), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and repair of injured myelin sheath for promoting functional recovery were also assessed in CCI model. Methods Totally 120 rats were divided randomly into four groups based on the surgical procedure of CCI (operated VS sham-operated) and the treatment (LLLT VS sham-operated LLLT).Each group was further divided into three subgroups according to the duration of LLLT treatment. The experimental groups in this study included (1) CCI + LLLT (CL group) included the 1-week (n=10), 2-week (n=10) and 3-week (n=10) of LLLT; (2) CCI+ sLLLT (CsL group) included the 1-week (n=10), 2-week (n=10) and 3-week (n=10) of sLLLT; (3) sCCI + LLLT (sCL group) included the 1-week (n=10), 2-week (n=10) and 3-week (n=10) of LLLT;(4) sCCI + sLLLT(sCsL group):included the 1-week (n=10), 2-week (n=10) and 3-week (n=10) of sLLLT. Seven days after surgery, animals started using the continuous 660-nm Ga-Al-As diode laser, and the output power of the laser irradiation was 30 mW per session with irradiation time for 60 sec/ per spot. The energy densities were 9 J/cm2. Effects of LLLT in CCI animals were determined by the measurements of mechanical pain threshold, sciatic function index, (SFI), tibial function index (TFI), peroneal function index (PFI), sciatic static index (SSI ), histopathological and immunohistochemical examination, ELISA and Western blot analysis. Histopathological and immunological assessements included accumulation of hypoxia-inducible factor-1 alpha (HIF-1α), proinflammatory cytokines interleukin-1β (IL-1β), tumor necrosis factorα (TNF-α), inducible nitric oxide syntheses (iNOS), cyclooxygenase enzymes-2 (COX-2), tumor suppressor protein p53 (p53) and macrophages for controlling neuropathic pain. Results Our results demonstrated that LLLT significantly improved mechanical pain threshold, sciatic functional index SFI, TFI, PFI, SSI (CL vs. CsL: P <0.05) after CCI. LLLT can also significantly reduce overexpressions of HIF-1α, TNF-α, IL-1β, iNOS, COX-2, p53, and the excessive macrophage accumulation (CL vs. CsL: P <0.05), and significantly promote the amounts of VEGF, NGF, and BDNF and myelin sheath (CL vs. CsL: P <0.05). But there was no significant differences among 1-, 2- and 3-week of LLLT on the expression of these protein factors (P>0.05). Conclusions After CCI nerve injury, LLLT can reduce neuropathic pain by suppressing the HIF-1α, TNF-α, IL-1β, iNOS, COX-2, p53 accumulation and macrophages infiltration and promote functional recovery by increasing the amounts of VEGF, NGF, BDNF and myelin sheath.
Soukupová, Zlata. "Poškozený v trestním řízení a jeho ochrana." Doctoral thesis, 2016. http://www.nusl.cz/ntk/nusl-352084.
Повний текст джерела