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1
Nelson, John O. "Induction: A Non-Sceptical Humean Solution." Philosophy 67, no. 261 (July 1992): 307–27. http://dx.doi.org/10.1017/s0031819100040432.
Повний текст джерелаАнотація:
Pre-analytically at least some of our inductions seem to be possessed of rational justification. This comment would apply, for instance, to my present induction, ‘If that climber high on the Flatirons falls he will be killed,’ not to mention such more momentous inductions as, ‘If a full-scale nuclear war breaks out there will be greater destruction than in World War II.’ Notoriously, however, a few Humean reflections seem to strip even the most plausible of our inductions of all possible rational justification, leaving them mere bare psychological faits accomplis: in effect, section V of the Enquiry's ‘Sceptical Solution of these Doubts.’
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Takizawa, Tsubasa, Mamoru Shibata, Yohei Kayama, Haruki Toriumi, Taeko Ebine, Anri Koh, Toshihiko Shimizu, and Norihiro Suzuki. "Temporal profiles of high-mobility group box 1 expression levels after cortical spreading depression in mice." Cephalalgia 36, no. 1 (April 10, 2015): 44–52. http://dx.doi.org/10.1177/0333102415580100.
Повний текст джерелаАнотація:
Introduction Cortical spreading depression (CSD) has recently been shown to induce the release of the nuclear protein termed high-mobility group box 1 from neurons, causing activation of the trigeminovascular system. Here, we explored the effects of single and multiple cortical spreading depression inductions on high-mobility group box 1 (HMGB1) transcriptional activity relative to high-mobility group box 1 protein expression levels and intracellular localization in cortical neurons and astrocytes. Methods Single or multiple cortical spreading depression inductions were achieved by KCl application to the mouse cerebral cortex. The animals were sacrificed at 30 minutes, 3 hours and 24 hours after cortical spreading depression induction. High-mobility group box 1 expression levels were explored with in situ hybridization, Western blotting and immunostaining. Results Cortical spreading depression up-regulated high-mobility group box 1 transcriptional activity in neurons at 3 hours in a manner that was dependent on the number of cortical spreading depression inductions. At 24 hours, the high-mobility group box 1 transcriptional activity had returned to basal levels. Cortical spreading depression induced a reduction in high-mobility group box 1 protein expression at 3 hours, which was also dependent on the number of cortical spreading depression inductions. Following cortical spreading depression, the release of high-mobility group box 1 from the nucleus was observed in a small proportion of neurons, but not in astrocytes. Conclusion Cortical spreading depression induced translocation of high-mobility group box 1 from neuronal nuclei, driving transcriptional up-regulation of high-mobility group box 1 to maintain protein levels.
3
Chen, Lu Zheng, Guo Dong Xu, Shu Ming Wen, Si Qing Liu, and Li Kun Gao. "Effect of Rod Arrangement in Matrix on High Gradient Magnetic Separation Performance." Advanced Materials Research 634-638 (January 2013): 3351–54. http://dx.doi.org/10.4028/www.scientific.net/amr.634-638.3351.
Повний текст джерелаАнотація:
The effect of rod arrangement in a rod matrix on high gradient magnetic separation (HGMS) performance has been comparatively investigated through a cyclic pilot-scale centrifugal HGMS separator, with contiguously and orthogonally arranged rod matrixes respectively. The results of investigation indicate that the arrangement of rod elements in the matrix has a distinct effect on the HGMS performance, for relatively low magnetic inductions; beyond the threshold magnetic induction, the magnetic induction dominates that of the arrangement and the importance of the arrangement is significantly weakened even vanished. It was thus concluded that the combinatorial optimization for magnetic elements in the matrix improves the collision efficiency of particles with matrix, and gives a superior performance in a HGMS separator, at a lower energizing consumption.
4
Appino, Carlo, Fausto Fiorillo, and Carlo Ragusa. "One-dimensional/two-dimensional loss measurements up to high inductions." Journal of Applied Physics 105, no. 7 (April 2009): 07E718. http://dx.doi.org/10.1063/1.3068540.
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Takizawa, Tsubasa, Mamoru Shibata, Yohei Kayama, Toshihiko Shimizu, Haruki Toriumi, Taeko Ebine, Miyuki Unekawa, Anri Koh, Akihiko Yoshimura, and Norihiro Suzuki. "High-mobility group box 1 is an important mediator of microglial activation induced by cortical spreading depression." Journal of Cerebral Blood Flow & Metabolism 37, no. 3 (July 20, 2016): 890–901. http://dx.doi.org/10.1177/0271678x16647398.
Повний текст джерелаАнотація:
Single episodes of cortical spreading depression (CSD) are believed to cause typical migraine aura, whereas clusters of spreading depolarizations have been observed in cerebral ischemia and subarachnoid hemorrhage. We recently demonstrated that the release of high-mobility group box 1 (HMGB1) from cortical neurons after CSD in a rodent model is dependent on the number of CSD episodes, such that only multiple CSD episodes can induce significant HMGB1 release. Here, we report that only multiple CSD inductions caused microglial hypertrophy (activation) accompanied by a greater impact on the transcription activity of the HMGB1 receptor genes, TLR2 and TLR4, while the total number of cortical microglia was not affected. Both an HMGB1-neurtalizing antibody and the HMGB1 inhibitor glycyrrhizin abrogated multiple CSD-induced microglial hypertrophy. Moreover, multiple CSD inductions failed to induce microglial hypertrophy in TLR2/4 double knockout mice. These results strongly implicate the HMGB1–TLR2/4 axis in the activation of microglia following multiple CSD inductions. Increased expression of the lysosomal acid hydrolase cathepsin D was detected in activated microglia by immunostaining, suggesting that lysosomal phagocytic activity may be enhanced in multiple CSD-activated microglia.
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Bannov, D. M. "ANALYSIS OF METHODS FOR DIAGNOSTICS BROKEN ROTOR BAR OF INDUCTION MOTOR." Electrical and data processing facilities and systems 17, no. 3-4 (2021): 5–23. http://dx.doi.org/10.17122/1999-5458-2021-17-3-4-5-23.
Повний текст джерелаАнотація:
Relevance Uninterrupted operation of industrial facilities, oil and gas sector, metallurgy, power generation and other industries directly depends on reliable operation of critical mechanisms driven by electromechanical converters, operated as a part of working complexes. Reliability of operation of such mechanisms depends on reliability of all elements that make up the technological process. Inductions motor with squirrel-cage rotor (including high-voltage motors) is one of the most common types of converters of electrical energy into mechanical energy. Its uninterrupted operation directly depends on the reliability of two main elements: stator and rotor. If the causes of induction motor failure due to stator causes (inter-turn, inter-phase and single-phase short circuits) are determined by the provided protections, the damage in the rotor circuit can be implicit and exist for a long time, violating the machine uptime. Also, most of the faults in the inductions motor, leading to an emergency shutdown of technological processes of working complexes have their own history of development. At the moment of occurrence and during the period when the defect does not affect the serviceability of the machine, but its operation becomes critically dangerous, because it is not possible to determine the presence of the defect. So, for example, the breakage of the short-circuited rotor core of a high-voltage induction motor manifests itself at the stage of exit to the air gap at the time of operation, with subsequent damage to the stator winding and the magnetic core. In this case, the existence of this defect took place within a certain period of time, sufficient for its detection by means of diagnostic devices. The article analyzes the currently developed systems for diagnosing the presence of a fault according to various parameters (temperature, noise, vibration, analysis of electrical values consumed) both in the stator and in the rotor. It is determined that the most promising and technically feasible are methods based on the analysis of stator currents. When studying the works in the direction of inductions motor diagnostics it was found that a significant proportion of failures of mechanisms operated in the working complexes due to failure of inductions motor occurs due to broken rotor bar. Aim of research Analyze the existing methods for diagnosing induction motors during operation. Research methods The article used general scientific research methods: the method of analysis of literary sources, the study and generalization of information, comparison, classification. Results The analysis of existing methods of continuous diagnostics of induction motors for internal electrical and mechanical damage is carried out. It has been determined that the most promising from the point of view of economic and technical feasibility are methods based on the analysis of currents consumed by the stator.
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Peng, Sheng-Yao, Yen-Yun Wang, Ting-Hsun Lan, Li-Ching Lin, Shyng-Shiou F. Yuan, Jen-Yang Tang, and Hsueh-Wei Chang. "Low Dose Combined Treatment with Ultraviolet-C and Withaferin a Enhances Selective Killing of Oral Cancer Cells." Antioxidants 9, no. 11 (November 13, 2020): 1120. http://dx.doi.org/10.3390/antiox9111120.
Повний текст джерелаАнотація:
Withaferin A (WFA), a Withania somnifera-derived triterpenoid, is an anticancer natural product. The anticancer effect of nonionizing radiation such as ultraviolet-C (UVC) as well as the combined treatment of UVC and WFA is rarely investigated. Low dose UVC and/or WFA treatments (12 J/m2 and/or 1 μM) were chosen to evaluate antioral cancer cell line effects by examining cytotoxicity, cell cycle disruption, apoptosis induction, and DNA damage. For two cancer cell lines (Ca9-22 and HSC-3), single treatment (UVC or WFA) showed about 80% viability, while a combined treatment of UVC/WFA showed about 40% viability. In contrast, there was noncytotoxicity to normal oral cell lines (HGF-1). Compared to single treatment and control, low dose UVC/WFA shows high inductions of apoptosis in terms of flow cytometric detections for subG1, annexin V, pancaspase changes as well as Western blotting for detecting cleaved poly (ADP-ribose) polymerase (c-PARP) and caspase 3 (c-Cas 3) and luciferase assay for detecting Cas 3/7 activity. Low dose UVC/WFA also showed high inductions of oxidative stress and DNA damage in terms of flow cytometric detections of reactive oxygen species (ROS), mitochondrial superoxide (MitoSOX) generation, and membrane potential (MitoMP) destruction, γH2AX and 8-oxo-2’deoxyguanosine (8-oxodG) types of DNA damages. For comparison, low dose UVC/WFA show rare inductions of annexin V, Cas 3/7 activity, ROS, MitoSOX, and MitoMP changes to normal oral HGF-1 cells. Therefore, low dose UVC/WFA provides a novel selectively killing mechanism to oral cancer cells, suggesting that WFA is a UVC sensitizer to inhibit the proliferation of oral cancer cells.
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Randall, David M., and W. Miles Cox. "EXPERIMENTAL MOOD INDUCTIONS IN PERSONS AT HIGH AND LOW RISK FOR ALCOHOL PROBLEMS." American Journal of Drug and Alcohol Abuse 27, no. 1 (January 2001): 183–87. http://dx.doi.org/10.1081/ada-100103126.
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Sinclair, Robert C., Tanya K. Lovsin, and Sean E. Moore. "Mood State, Issue Involvement, and Argument Strength on Responses to Persuasive Appeals." Psychological Reports 101, no. 3 (December 2007): 739–53. http://dx.doi.org/10.2466/pr0.101.3.739-753.
Повний текст джерелаАнотація:
This study investigated the effects of mood state, issue involvement, and argument strength on responses to persuasive appeals. Through an unrelated second study paradigm, 144 introductory psychology students were randomly assigned to High or Low Issue Involvement, Happy or Sad Mood Inductions, and Strong or Weak Argument conditions. Attitudes, measured on 9-point Likert-type scales, and cognitive responses, measured through a thought listing, were assessed. On attitudes, people in the Happy Induction condition were equally persuaded by Strong and Weak Arguments, whereas people in the Sad Induction condition were persuaded by Strong, but not Weak, Arguments. Involvement had no effect. On the thought-listing measures, people in the Happy Induction condition showed modest elaboration. A stronger pattern of effects, consistent with high elaboration, was noted on the thought listings of people in the Sad Induction condition and who were in the High Involvement group. Interestingly, people in the Sad Induction condition who were in the Low Involvement group showed mood-congruency on thoughts. The data suggest that the effects of mood state are not moderated by the effects of issue Involvement on this measure of attitudes but that there may be some moderation on measures of elaboration. Implications and directions for research are discussed.
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Sung, Guo-Ming, Hsin-Kwang Wang, and Leenendra Chowdary Gunnam. "A One-Dimensional Magnetic Chip with a Hybrid Magnetosensor and a Readout Circuit." Journal of Sensors 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/6436481.
Повний текст джерелаАнотація:
This work presents a one-dimensional magnetic chip composed of a hybrid magnetosensor and a readout circuit, which were fabricated with 0.18 μm 1P6M CMOS technology. The proposed magnetosensor includes a polysilicon cross-shaped Hall plate and two separated metal-oxide semiconductor field-effect transistors (MOSFETs) to sense the magnetic induction perpendicular to the chip surface. The readout circuit, which comprises a current-to-voltage converter, a low-pass filter, and an instrumentation amplifier, is designed to amplify the output Hall voltage with a gain of 43 dB. Furthermore, a SPICE macro model is proposed to predict the sensor’s performance in advance and to ensure sufficient comprehension of the magnetic mechanism of the proposed magnetosensor. Both simulated and measured results verify the correctness and flexibility of the proposed SPICE macro model. Measurements reveal that the maximum output Hall voltage VH, the optimum current-related magnetosensitivity SRI, the optimum voltage-related magnetosensitivity SRV, the averaged nonlinearity error NLE, and the relative bias current Ibias are 4.381 mV, 520.5 V/A·T, 40.04 V/V·T, 7.19%, and 200 μA, respectively, for the proposed 1-D magnetic chip with a readout circuit of 43 dB. The averaged NLE is small at high magnetic inductions of ±30 mT, whereas it is large at low magnetic inductions of ±30 G.
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Fleming, Susan E., Roxanne Vandermause, Michele Shaw, and Billie Severtsen. "Grand Multiparous Mothers’ Embodied Experiences of Natural and Technological Altered Births." Journal of Perinatal Education 26, no. 2 (2017): 85–95. http://dx.doi.org/10.1891/1058-1243.26.2.85.
Повний текст джерелаАнотація:
ABSTRACTIn-depth interviews of a purposive sample (n = 14) of grand multipara mothers (five or more births) was conducted to investigate the mothers’ embodied experiences of natural, technologically altered births and oxytocin inductions in U.S. hospitals from 1973 to 2007. A comprehensive secondary analysis of the lived experiences of natural birth and the high use of technology and oxytocin during birth, which was found in an original theme of a previous study, was explored. An overarching theme emerged of Embodiment of Birthing in U.S. Hospitals. Two patterns: Embodied Technological Altered Natural Births and Embodied Technologically Altered Induced Births were uncovered. Childbirth educators, doulas, and nurses are an integral part of creating changes in hospital settings, which discourage nonmedically indicated inductions and encourages changes in hospitals.
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Carlson, Nicole S., Jennifer K. Frediani, Elizabeth J. Corwin, Anne Dunlop, and Dean Jones. "Metabolic Pathways Associated With Term Labor Induction Course in African American Women." Biological Research For Nursing 22, no. 2 (January 27, 2020): 157–68. http://dx.doi.org/10.1177/1099800419899730.
Повний текст джерелаАнотація:
Objectives: The purpose of this study was to evaluate differences in the metabolic pathways activated in late-pregnancy serum samples among African American women who went on to have term (≥37 weeks) labor induction requiring high total oxytocin doses to complete first-stage labor compared to those in similar women with low-oxytocin labor inductions. Study Design: Case–control study ( N = 27 women with labor induction with successful cervical ripening: 13 requiring the highest total doses of synthetic oxytocin to progress from 4- to 10-cm cervical dilation and 14 requiring the lowest total doses) with groups balanced on parity and gestational age. Serum samples obtained between 24 and 30 weeks’ gestation were analyzed using ultra-high-resolution metabolomics. Differentially expressed metabolites between high-oxytocin induction cases and low-oxytocin induction comparison subjects were evaluated using linear regression with xmsPANDA. Metabolic pathways analysis was conducted using Mummichog Version 2.0, with discriminating metabolites annotated using xMSannotator Version 1.3. Results: Labor processes were similar by group with the exception that cases received over 6 times more oxytocin between 4- and 10-cm cervical dilation than comparison women. Induction requiring high total doses of synthetic oxytocin was associated with late-pregnancy serum levels of metabolites from the linoleate and fatty acid activation pathways in term, African American women. Conclusion: Serum levels of several lipid metabolites predicted more complicated labor induction involving higher doses of synthetic oxytocin to complete first-stage labor. Further investigation in larger, more diverse cohorts of women is needed to identify potential targets to prevent failed labor induction.
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Begum, Najma, and Louis Ragolia. "High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK activation." American Journal of Physiology-Cell Physiology 278, no. 1 (January 1, 2000): C81—C91. http://dx.doi.org/10.1152/ajpcell.2000.278.1.c81.
Повний текст джерелаАнотація:
Our laboratory has recently demonstrated a role for the phosphatidylinositol 3-kinase-mediated inducible NO synthase (iNOS) signaling pathway in acute regulation of insulin-induced mitogen-activated protein phosphatase-1 (MKP-1) expression in primary cultures of rat aortic vascular smooth muscle cells (VSMCs) (N. Begum, L. Ragolia, M. McCarthy, and N. Duddy. J. Biol. Chem. 273: 25164–25170, 1998). We now show that prolonged treatment of VSMCs with 100 nM insulin and high glucose (25 mM) for 12–24 h, to mimic hyperinsulinemia and hyperglycemia, completely blocked MKP-1 mRNA and protein expression in response to subsequent acute insulin treatment. To understand the mechanism of insulin resistance induced by high glucose and insulin, we studied the regulation of iNOS protein induction in these cells. Both high glucose and chronic insulin treatment caused a marked impairment of iNOS induction in response to acute insulin. Blocking of signaling via the p38 mitogen-activated protein kinase (MAPK) pathway by prior treatment for 1 h with SB-203580, a synthetic p38 MAPK inhibitor, completely prevented the inhibition of iNOS induced by high glucose and insulin and restored MKP-1 induction to levels observed with acute insulin treatment. In contrast, PD-98059, a MEK inhibitor, had no effect. Furthermore, high glucose and chronic insulin treatment caused sustained p38 MAPK activation. We conclude 1) that chronic insulin and high glucose-induced insulin resistance is accompanied by marked reductions in both iNOS and MKP-1 inductions due to p38 MAPK activation that leads to excessive cell growth and 2) that p38 MAPK/extracellular signal-regulated kinase pathways regulate iNOS induction, thereby controlling MKP-1 expression, which in turn inactivates MAPKs as a feedback mechanism and inhibits cell growth.
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Hagen, Grace, Crystal Brown, Jordan Dietrich, Charles Gibbs, and Gene T. Lee. "The Utility of Lower Glycemic Targets for Treating Gestational Diabetes: A Retrospective Study." Journal of Diabetes Research 2019 (December 5, 2019): 1–6. http://dx.doi.org/10.1155/2019/6372474.
Повний текст джерелаАнотація:
Objective. In vivo study of glucose homeostasis in pregnancy suggests normal glucose levels are lower than current glycemic targets used in gestational diabetes. After the HAPO study results, our institution began using glycemic targets of fasting 85 mg/dL and 2-hour postprandial of 110 mg/dL. We reviewed our results. Methods. A retrospective cohort of GDM patients that delivered at KUMC from January 2007 to May 2017 was reviewed. All patients were diagnosed with the 2-step Carpenter-Coustan thresholds. High targets were compared with low targets. The primary outcome investigated was birthweight>90% (large for gestational age, LGA). Results. 604 patients were studied, and 34% were treated with low glycemic targets. Our unadjusted results showed that the low-target group had a lower incidence of LGA infants (24.0 vs. 31.8%), higher incidence of neonatal hypoglycemia (20.7 vs. 11.6%), and inductions (39.4 vs. 20.5%). After adjustment for demographic variables, only a higher risk of inductions remained (aOR 2.54 (1.44, 4.49)). Conclusion. Lower glycemic targets did not produce large reductions in fetal overgrowth, but they were associated with a higher rate of inductions. As there were no observed differences in maternal or neonatal outcomes otherwise, aiming for lower glycemic targets in GDM is likely not cost-effective.
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Kalinnikov, G. V., R. A. Andrievski, and V. K. Egorov. "Amorphous/Nanocrystalline Films Prepared by Magnetron Sputtering with Additional External Magnetic Field." Journal of Nano Research 6 (June 2009): 89–98. http://dx.doi.org/10.4028/www.scientific.net/jnanor.6.89.
Повний текст джерелаАнотація:
Combined amorphous and nanocrystalline films attract an attention due to possibility to improve toughness, wear resistance and other properties which are important in nanomaterials and processes in energy systems. One of the known film fabrication methods is the magnetron sputtering deposition in the presence of an additional external magnetic field with inductions of up to 0.3 T as it was demonstrated by an example of the B4C-TiB2 system. The induction effects on the amorphous films hardness, growth rate and nanocrystallization process were investigated and discussed. The deposition under an additional external magnetic field with induction more than 0.2 T leads to the of nc-inclusions formation as was determined by X-ray diffraction, microdiffraction and high resolution transmission electron microscopy methods. The target and film compositions were determined by energy disperse spectroscopy and Rutherford backscattering spectroscopy. Compared to the target composition, some enrichment by nonmetallic elements (carbon and boron) was fixed in films.
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Slack, J. M. W., B. G. Darlington, L. L. Gillespie, S. F. Godsave, H. V. Isaacs, and G. D. Paterno. "The role of fibroblast growth factor in early Xenopus development." Development 107, Supplement (April 1, 1989): 141–48. http://dx.doi.org/10.1242/dev.107.supplement.141.
Повний текст джерелаАнотація:
In early amphibian development, the mesoderm is formed around the equator of the blastula in response to an inductive signal from the endoderm. A screen of candidate substances showed that a small group of heparin-binding growth factors (HBGFs) were active as mesoderm-inducing agents in vitro. The factors aFGF, bFGF, kFGF and ECDGF all show similar potency and can produce inductions at concentrations above about 100 pM. The product of the murine int-2 gene is also active, but with a lower specific activity. Above the induction threshold there is a progressive increase of muscle formation with dose. Single blastula ectoderm cells can be induced and will differentiate in a defined medium to form mesodermal tissues. All inner blastula cells are competent to respond to the factors but outer cells, bearing oocyte-derived membrane, are not. Inducing activity can be extracted from Xenopus blastulae and binds to heparin like the previously described HBGFs. Antibody neutralization and Western blotting experiments identify this activity as bFGF. The amounts present are small but would be sufficient to evoke inductions in vivo. It is not yet known whether the bFGF is localized to the endoderm, although it is known that inducing activity secreted by endodermal cells can be neutralized by heparin. The competence of ectoderm to respond to HBGFs rises from about the 128-cell stage and falls again by the onset of gastrulation. This change is paralleled by a rise and fall of binding of 125I-aFGF. Chemical cross-linking reveals that this binding is attributable to a receptor of relative molecular mass about 130 × 103. The receptor is present both in the marginal zone, which responds to the signal in vivo, and in the animal pole region, which is not induced in vivo but which will respond to HBGFs in vitro. In the embryo, the induction in the vicinity of the dorsal meridian is much more potent than that around the remainder of the marginal zone circumference. Dorsal inductions contain notochord and will dorsalize ventral mesoderm with which they are later placed in contact. This effect might be due to a local high bFGF concentration or, more likely, to the secretion in the dorsal region of an additional, synergistic factor. It is known that TGF-β-1 and -2 can greatly increase the effect of low doses of bFGF, although it has not yet been demonstrated that they are present in the embryo. Lithium salts have a dorsalizing effect on whole embryos or on explants from the ventral marginal zone, and also show potent synergism when applied together with HBGFs.
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Stein, Anthony Selwyn, M. O’Donnell, P. Parker, R. Spielberger, A. Nademanee, R. Bhatia, D. S. Snyder, et al. "Analysis of Long Term Outcome in Autologous Stem Cell Transplant (ASCT) for Acute Myelogenous Leukemia (AML) in First Remission (CR1) - a 15 Year Experience." Blood 104, no. 11 (November 16, 2004): 1870. http://dx.doi.org/10.1182/blood.v104.11.1870.1870.
Повний текст джерелаАнотація:
Abstract Despite improvement in the proportion of patients achieving durable remission with dose intensive consolidation strategies, leukemic relapse still occurs in 40–70% of patients who achieve an initial remission. Studies utilizing ASCT for AML in CR1 have reported relapse free survival between 34–80% based on cytogenetic risk stratification. We report a 15 year experience of ASCT following high dose cytarabine (Ara-C) ± idarubicin (IDA) consolidation in 168 patients (intent to transplant, ITT) in CR1 treated between 3/89 and 6/03. The treatment consisted of a): consolidation with high dose Ara-C ± IDA followed by marrow (M) harvest (n=64) or collection of G-CSF primed stem cells (PSCs) (n=73), b) ASCT using FTBI 12Gy, Etoposide 60mg/kg, Cytoxan 75mg/kg (n=97) or Busulfan targeted to 1st dose AUC 700–900, FTBI 1200Gy and Etoposide 30mg/kg (n=40), and c) IL-2 9x106 IU/m2/24 hrs days 1–4 and IL-2 1.6 x 106 IU/m2/24 hrs days 9–18 beginning at hematologic recovery post ASCT (from 1995-present). Patient characteristics at ITT were median age 40.8 yr. (16.3–60.9); cytogenetics (SWOG criteria) favorable = 42(25%) (including 11 M3 pre 1993), intermediate=70(42%), unfavorable=16(10%), indeterminate and unknown=40(23%); WBC <50,000=125(74%), ≥50,000=41(25%), unknown=2(1%); 147 (88%) received one induction cycle and 12% received two cycles; Ara-C induction dose was 100–200mg/m2 in 49% and 51% received high dose Ara-C induction. Median time from CR1 to consolidation was 27.6 days. Of the 168 patients consolidated, 137 had ASCT. The 100-day non-relapse mortality (NRM) for consolidation+ASCT was 2%. With a median follow up of 9.5 yrs, the 5 yr OS, DFS relapse rate (RR) for 168 ITT patients is 57%, 51%, and 41% respectively. The 5 yr OS, DFS and RR for each cytogenetic category are: favorable 64%, 63%, 29%; intermediate 58%, 50%, 41%; unfavorable 45%, 31%, 67%; and unknown cytogenetics 49%, 48%, 44% respectively. The 5 yr OS, DFS and RR for the 137 transplanted patients were 62%, 59%, and 36%. The 5 year OS and RR for favorable cytogenetics are 69%, 24%; intermediate 62%, 36%; unfavorable 55%, 58%; and unknown 55%, 42% respectively. Prognostic variables analyzed for each outcome in the ITT group were: age, WBC, cytogenetics, Ara-C induction dose, one vs. two inductions and IDA in consolidation. By multivariate analyses the number of inductions was predictive for OS with hazard ratio=2.2 (95%CI:1.2–4.3) p=0.02. No variables were found to be predictive of DFS or relapse. The same variables with the addition of conditioning regimen, IL-2 and M vs. PSCs were analyzed for the 137 transplant patients. By multivariate analysis IL-2 was predictive for OS and DFS and cytogenetics was predictive of relapse. These results demonstrate that the strategy of high dose Ara-C consolidation followed by ASCT can be performed with low NRM. This approach appears to improve the outcome of patients with all cytogenetic risk groups when compared with multiple cycles of high dose Ara-C. The role of post-transplant IL-2 appears to be beneficial and merits further investigation.
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Chen, Wei, Qing Xuan Jia, Han Xu Sun, and Si Cheng Nian. "Fault Detection for Roller Bearing with Vibration Analysis and Information Fusion in Sorting Machine Induction." Applied Mechanics and Materials 494-495 (February 2014): 805–8. http://dx.doi.org/10.4028/www.scientific.net/amm.494-495.805.
Повний текст джерелаАнотація:
Due to continuous metal-metal contacts in heavy and high-speed operating conditions, sorting machine inductions roller bearing easily occurs malfunctions. Therefore, its crucial to make incipient fault diagnosis. This paper presents a novel diagnosis algorithm using vibration analysis and information fusion. In the algorithm, vibration signal for roller bearing is firstly analyzed. Then extracted fault features are used as input eigenvector of constructed neural network classifier. In order to improve diagnosis accuracy, take output information of each single classifier as independent evidence, and aggregate them using improved Dempsters combination rule. Experiment results show that proposed algorithm has high accuracy of 99.5%.
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Ritchie, Ellen K., Tara L. Lin, Laura F. Newell, Robert K. Stuart, Scott R. Solomon, Richard M. Stone, Gary J. Schiller, et al. "Outcomes with CPX-351 versus 7+3 by baseline bone marrow (BM) blast percentage in older adults with newly diagnosed high-risk/secondary acute myeloid leukemia (sAML)." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): 7042. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.7042.
Повний текст джерелаАнотація:
7042 Background: CPX-351, a liposomal encapsulation of cytarabine (C) and daunorubicin (D) at a synergistic ratio, is approved as Vyxeos in the US and EU for adults with newly diagnosed therapy-related AML or AML with myelodysplasia-related changes. In a phase 3 study, CPX-351 significantly improved OS and remission rates vs 7+3 in patients (pts) aged 60-75 y with newly diagnosed high-risk/sAML. Some studies suggest a high baseline blast percentage may portend a worse prognosis in AML. This post hoc analysis of phase 3 data assessed outcomes by baseline BM blast percentage. Methods: Pts diagnosed with AML per 2008 WHO criteria (≥20% blasts in peripheral blood or BM) were randomized 1:1 to receive ≤2 inductions of CPX-351 (100 units/m2 [C 100 mg/m2 + D 44 mg/m2] on Days 1, 3, 5 [2nd induction: Days 1, 3]) or 7+3 (C 100 mg/m2/d continuously for 7 d [2nd induction: 5 d] + D 60 mg/m2 on Days 1-3 [2nd induction: Days 1-2]). Pts achieving complete remission (CR) or CR with incomplete platelet or neutrophil recovery (CRi) could receive ≤2 consolidations. Results: CPX-351 had longer median OS and higher remission rates vs 7+3 irrespective of baseline BM blast percentage; median OS was worse in higher blast groups for both treatments (Table). The incidence of grade ≥3 TEAEs was >80% for both arms; febrile neutropenia was the most common. Conclusions: Improved outcomes were observed with CPX-351 vs 7+3 irrespective of baseline BM blast percentage in older adults with newly diagnosed high-risk/sAML. Clinical trial information: NCT01696084. [Table: see text]
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DONALDSON, C., and D. LAM. "Rumination, mood and social problem-solving in major depression." Psychological Medicine 34, no. 7 (October 2004): 1309–18. http://dx.doi.org/10.1017/s0033291704001904.
Повний текст джерелаАнотація:
Background. Ruminating when depressed is thought to lower mood and impair problem-solving, while distraction is thought to alleviate mood and assist problem-solving. The present study investigates each of these proposals using both naturally occurring and experimentally induced rumination and distraction in a sample of patients with major depression.Method. Thirty-six patients with major depression and 36 control participants were randomly allocated to either a rumination or distraction induction condition. Levels of trait rumination and distraction were measured at baseline, mood and problem-solving were measured before and after the inductions.Results. In terms of trait measures, depressed patients with higher levels of trait rumination reported poorer mood and gave less effective problem solutions than those who were less ruminative. Trait distraction was not associated with mood or problem-solving. In terms of induced responses, depressed patients who were made to ruminate experienced a deterioration in their mood and gave poorer problem solutions. For those receiving the distraction induction, mood improved in all patients and problem-solving improved in patients who were not naturally ruminating at a high level. Neither induction had an impact on mood or problem-solving in control participants.Conclusions. Treatment for depression associated with adverse life events may need to target rumination as well as problem-solving deficits if interventions are to be effective. The differential effects of self-applied versus experimentally induced distraction require further investigation. Future research will need to consider that high levels of trait rumination may interfere with the impact of experimental inductions.
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Qin, Pu, Lisa A. Borges-Marcucci, Mark J. Evans, and Douglas C. Harnish. "Bile acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes." American Journal of Physiology-Gastrointestinal and Liver Physiology 289, no. 2 (August 2005): G267—G273. http://dx.doi.org/10.1152/ajpgi.00043.2005.
Повний текст джерелаАнотація:
Previous studies have demonstrated a dramatic induction of inflammatory gene expression in livers from mice fed a high-fat, high-cholesterol diet containing cholate after 3–5 wk. To determine the contribution of cholate in mediating these inductions, C57BL/6 mice were fed a chow diet supplemented with increasing concentrations of cholic acid (CA) for 5 days. A dose-dependent induction in the hepatic levels of TNF-α, VCAM-1, ICAM-1, and SAA-2 mRNA were observed. As positive controls, a dose-dependent repression of cholesterol 7α-hydroxylase and a dose-dependent induction of small heterodimer partner (SHP) expression were also observed, suggesting that farnesoid X receptor (FXR) was activated. In addition, ICAM-1 and SHP mRNA levels were also induced in primary human hepatocytes when treated with chenodeoxycholic acid or GW4064, a FXR-selective agonist. The involvement of FXR in CA-induced inflammatory gene expression was further investigated in the human hepatic cell line HepG2. Both ICAM-1 and SHP expression were induced in a dose- and time- dependent manner by treatment with the FXR-selective agonist GW4064. Moreover, the induction of ICAM-1 by GW4064 was inhibited by the FXR antagonist guggulsterone or with transfection of FXR siRNA. Finally, the activity of FXR was mapped to a retinoic acid response element (RARE) site containing an imbedded farnesoid X response element (FXRE) on the human ICAM-1 promoter and FXR and retinoid X receptor were demonstrated to bind to this site. Finally, FXR-mediated activation of ICAM-1 could be further enhanced by TNF-α cotreatment in hepatocytes, suggesting a potential cooperation between cytokine and bile acid-signaling pathways during hepatic inflammatory events.
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Kündig, E. Peter, Yixia Jia, Dmitry Katayev, and Masafumi Nakanishi. "Asymmetric Pd-NHC*-catalyzed coupling reactions." Pure and Applied Chemistry 84, no. 8 (July 1, 2012): 1741–48. http://dx.doi.org/10.1351/pac-con-12-02-10.
Повний текст джерелаАнотація:
Very high asymmetric inductions result in the Pd-catalyzed intramolecular arylation of amides to give 3,3-disubstituted oxindoles when new in situ-generated chiral N-heterocyclic carbene (NHC*) ligands are employed. Structural studies show that conformational locking to minimize allylic strain is the key to understanding the function of these ligands. New applications of these ligands in the frontier area of asymmetric coupling reactions involving C(sp3)–H bonds are detailed. Highly enantioenriched fused indolines are accessible using either preformed- or in situ-generated Pd-NHC* catalysts. Remarkably, this occurs at high temperature (140–160 °C) via excellent asymmetric recognition of an enantiotopic C–H bond in an unactivated methylene unit.
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Place, Katariina, Leena Rahkonen, Niina Verho-Reischl, Katti Adler, Seppo Heinonen, and Heidi Kruit. "Childbirth experience in induced labor: A prospective study using a validated childbirth experience questionnaire (CEQ) with a focus on the first birth." PLOS ONE 17, no. 10 (October 6, 2022): e0274949. http://dx.doi.org/10.1371/journal.pone.0274949.
Повний текст джерелаАнотація:
Objective First birth and labor induction are risk factors for negative childbirth experiences. As labor inductions are increasing, research into this high-risk group’s childbirth experiences is important. We aimed to investigate whether nulliparity or factors related to labor induction, labor, and delivery explain the association. Methods This was a prospective study of 711 women undergoing labor induction at Helsinki University Hospital, Finland, between January 1, 2019, and January 31, 2020. The participants answered the Childbirth Experience Questionnaire (CEQ) after delivery (response rate 69.4%). The patient characteristics and delivery outcomes were collected from patient records. We analyzed the results for nulliparous and parous women. Results The mean CEQ scores were 2.9 (SD 0.5) for nulliparous women (n = 408) and 3.2 (SD 0.5) for parous women (n = 303), on a scale of 1–4; higher scores represent more positive experiences. However, 7.3% of the women had negative childbirth experiences (8.8% nulliparous; 5.3% parous, p = 0.08). Negative experiences were associated with a cesarean section (OR 6.7, 95% CI 1.8–9.3, p < 0.001) and a hemorrhage ≥ 1500 ml in vaginal delivery (OR 2.8, 95% CI 1.1–7.5, p = 0.03). In the separate CEQ domains analyses, nulliparity was associated with negative experiences in the “Own Capacity” domain (OR 1.6, 95% CI 1.0–2.4, p = 0.03). Cervical ripening, oxytocin use, and daytime delivery were associated with negative experiences in at least one domain, whereas epidural or spinal analgesia was regarded positively in two domains and negatively in one. Conclusions Nulliparous women undergoing labor induction risk negative childbirth experiences mainly due to labor and delivery-related factors, similar to parous women. Their perceptions of their capacity and preparedness for labor and delivery should be enhanced antenatally. An effective labor induction protocol promoting as high a rate of vaginal delivery as possible and preparedness to promptly respond to postpartum hemorrhage are key for avoiding negative childbirth experiences.
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Suzuki, A., and Y. Tsutomi. "Inductions of fibroblast-like morphology and high growth activity by low-dose CPT-11 in PC12 cells: role of tenascin." Toxicology in Vitro 14, no. 4 (August 2000): 337–43. http://dx.doi.org/10.1016/s0887-2333(00)00021-7.
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Lehrnbecher, Thomas, Martin Zimmermann, Dirk Reinhardt, Michael Dworzak, Jan Stary, and Ursula Creutzig. "Prophylactic human granulocyte colony-stimulating factor after induction therapy in pediatric acute myeloid leukemia." Blood 109, no. 3 (September 28, 2006): 936–43. http://dx.doi.org/10.1182/blood-2006-07-035915.
Повний текст джерелаАнотація:
Abstract Children with acute myelogenous leukemia (AML) have a high risk of infectious complications that might be reduced by prophylactic granulocyte colony-stimulating factor (G-CSF). However, G-CSF could induce AML blast proliferation. The prospective randomized trial AML-BFM 98 investigated the impact of G-CSF on hematopoetic recovery and infectious complications (primary endpoints) and on outcome (secondary endpoint) in children (aged 0-18 years) with de novo AML. Patients with more than 5% blasts in day-15 bone marrow or with FAB M3 were not included. Between 1998 and 2003, 161 children with AML were randomized to receive G-CSF after inductions 1 and 2, whereas 156 patients were assigned to the control group. Time of neutropenia after inductions 1 and 2 was significantly shorter in the G-CSF group (23 vs 18 days and 16 vs 11 days; P = .02 and = .001, respectively). G-CSF did not decrease the incidence of febrile neutropenia (72 and 36 patients vs 78 and 37 patients, respectively), microbiologically documented infections (27 and 25 patients vs 36 and 19 patients, respectively) and infection-associated mortality (5 vs 2 patients). Both groups had similar 5-year event-free survival (EFS; 59% ± 4% vs 58% ± 4%). Since G-CSF does not influence the risk of infectious complications or outcome in children undergoing therapy for AML, one cannot advocate the routine use of G-CSF in this patient group.
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Li, Tse Chang, and Jen Fin Lin. "A Plasma Spray Coating for Titanium Particles Using Software Simulation." Key Engineering Materials 661 (September 2015): 149–55. http://dx.doi.org/10.4028/www.scientific.net/kem.661.149.
Повний текст джерелаАнотація:
In the present study, a plasma spray coating for titanium particles was studied using software simulations. The governing equations to solve the velocity and temperature distributions of plasma flow and titanium particles considered the effects of electric/magnetic inductions. Seven controlling factors were included in order to investigate their effects on the velocity and temperature of titanium particles colliding with the specimen substrate and the colliding scope of the effective particle depositions. The velocity and temperature distributions of the plasma flow predicted in the present study were expressed in a power form. The results predicted by the present governing equations were thus trustworthy. In general, either a small particle diameter in collaboration with a low electric potential or a large particle diameter in collaboration with a high electric potential is advantageous for a high melting and boiling points.
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Kansara, Vijay M., Kunal D. Kadakar, Akash S. Chikani, and Pinal A. Pateliya. "The association between isolated oligohydramnios at term and pregnancy outcome and perinatal outcome in case of isolated oligohydramnosis: a retrospective analysis." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 11, no. 1 (December 28, 2021): 136. http://dx.doi.org/10.18203/2320-1770.ijrcog20215090.
Повний текст джерелаАнотація:
Background: Current study was carried out to assess the impact of isolated oligohydramnios on perinatal outcomes and mode of delivery.Methods: A retrospective observational cohort study was conducted at term pregnancy with sonographic finding of isolated oligohydramnios (AFI <5 cm) were recruited for the study. Uterine anomaly and high risk pregnancies were excluded from the study. The mode of delivery and perinatal outcome were compared with control group of pregnancy with normal amniotic fluid (AFI >5-25 cm).Results: When compared to the normal AFI, women with oligohydramnios had significantly lower birth weight babies and were delivered at a significantly earlier gestational age. However there was no difference in the APGAR scores at birth and NICU admissions between the two groups. Reactive NST had more chances of good APGAR score at 1 and 5 minute and that lower the AFI more the probability of nonreactive NST and abnormal Doppler. The number of inductions and caesareans done for foetal reasons were significantly higher in the exposed group.Conclusions: Obstetric and perinatal outcome remains similar in both isolated oligohydramnios with reactive NST as well as in patients with normal amniotic fluid index. Isolated oligohydramnios is not associated with adverse perinatal outcomes. However, it increases the risk for labour induction and caesarean section.
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Nishiyama, Kazuhiro, Kohei Ariyoshi, Akiyuki Nishimura, Yuri Kato, Xinya Mi, Hitoshi Kurose, Sang Geon Kim, and Motohiro Nishida. "Knockout of Purinergic P2Y6 Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis." International Journal of Molecular Sciences 24, no. 4 (February 14, 2023): 3800. http://dx.doi.org/10.3390/ijms24043800.
Повний текст джерелаАнотація:
Nonalcoholic steatohepatitis (NASH) is a disease that progresses from nonalcoholic fatty liver (NAFL) and which is characterized by inflammation and fibrosis. The purinergic P2Y6 receptor (P2Y6R) is a pro-inflammatory Gq/G12 family protein-coupled receptor and reportedly contributes to intestinal inflammation and cardiovascular fibrosis, but its role in liver pathogenesis is unknown. Human genomics data analysis revealed that the liver P2Y6R mRNA expression level is increased during the progression from NAFL to NASH, which positively correlates with inductions of C-C motif chemokine 2 (CCL2) and collagen type I α1 chain (Col1a1) mRNAs. Therefore, we examined the impact of P2Y6R functional deficiency in mice crossed with a NASH model using a choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD). Feeding CDAHFD for 6 weeks markedly increased P2Y6R expression level in mouse liver, which was positively correlated with CCL2 mRNA induction. Unexpectedly, the CDAHFD treatment for 6 weeks increased liver weights with severe steatosis in both wild-type (WT) and P2Y6R knockout (KO) mice, while the disease marker levels such as serum AST and liver CCL2 mRNA in CDAHFD-treated P2Y6R KO mice were rather aggravated compared with those of CDAHFD-treated WT mice. Thus, P2Y6R may not contribute to the progression of liver injury, despite increased expression in NASH liver.
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Slack, J. M. "The nature of the mesoderm-inducing signal in Xenopus: a transfilter induction study." Development 113, no. 2 (October 1, 1991): 661–69. http://dx.doi.org/10.1242/dev.113.2.661.
Повний текст джерелаАнотація:
A transfilter apparatus is described, which is suitable for neutralization experiments on embryonic induction, and it is used to investigate the sensitivity of the Xenopus mesoderm-inducing signal to various inhibitors. The vegetal (inducing) tissue is placed on one side of a membrane sandwich and the animal (responding) tissue on the other side. The sandwich consists of a nylon gauze in between two Nucleopore filters and enables inhibitors in the solution to have effective access to the gap between the tissues. Control experiments show a high proportion of positive inductions of a ventral character. Using this apparatus, it is shown that the protein follistatin, which effectively inhibits activin A and B in vitro, has little or no effect on the natural signal. Likewise, antibodies to basic fibroblast growth factor, which inhibit in vitro, do not inhibit the natural signal. The two inhibitors together have a slight effect. It is concluded that neither activin nor bFGF are major components of the signal emitted by the vegetal cells of the Xenopus blastula and transmitted across the liquid gap, although they might have some other role to play in the process. Two agents of lower specificity do inhibit the transfilter induction: heparin and suramin. Suramin will also inhibit induction in animal-vegetal combinations with no intervening membranes while heparin does not. This suggests that the heparin inhibition can only occur when there is a liquid gap between the tissues, presumably because it can neutralize the signal in solution but cannot penetrate the explants themselves. The endogenous mesoderm-inducing factor(s) should therefore be sensitive to heparin in vitro.
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Kaufman, Jonathan L., Charise Gleason, Leonard Heffner, and Sagar Lonial. "Bortezomib, Thalidomide, and Dexamethasone as Induction Therapy for Patients with Symptomatic Multiple Myeloma." Blood 110, no. 11 (November 16, 2007): 3605. http://dx.doi.org/10.1182/blood.v110.11.3605.3605.
Повний текст джерелаАнотація:
Abstract The optimal induction regimen for patients with symptomatic myeloma who are eligible for transplantation is currently unknown. While thalidomide and dexamethasone is an effective regimen, it only has a 60 to 65% response rate and few complete responses (CR). Bortezomib based inductions have demonstrated a high response rate and an improved CR as well. Recently the IFM reported the initial results of the randomized bortezomib plus dexamethasone versus VAD induction followed by transplant, which demonstrated that fewer patients treated with bortezomib required tandem transplants. Wang et al reported a high induction response rate with the combination of BTD for only 2 cycles given over a 28 day cycle. Here we report our experience with the combination of BTD as induction therapy. 38 patients with symptomatic myeloma were treated with BTD as induction therapy. Patients received standard dose and schedule bortezomib at 1.3 mg/m2 on days 1, 4, 8, and 11 with thalidomide at 100 mg/day, and 8 days of 40 mg dexamethasone every 21 days. The median age was 58 years (38–70) with 19 males. This was first line therapy for 29 patients, second line for 7 patients and 3rd line for 2. 12 patients had ISS stage 2 and 8 had ISS stage 3. The median β2M was 3.4 (1.66–41.89). Median creatinine was 1.1 (0.6–21.0). Nineteen patients had an IgG paraprotein, 6 an IgA, and 16 patients had light chain disease. The median number of cycles administered was 4 (2–8). Fifteen patients developed neuropathy of any grade. One patient developed grade 3 neuropathy. The overall response rate (CR, VGPR, plus PR) was 92%, with 58% of patients achieving a VGPR or better, and 21% of patients achieving an immunofixation negative CR. 1 patient had a minimal response and 2 patients had progressive disease (both patients presented with plasma cell leukemia). These two patients were treated with the combination of BTD with PACE chemotherapy. One of the two died from progressive disease and the other patient remains in complete remission after high dose therapy and autologous transplantation. 29 patients had consolidation therapy with high dose melphalan and autologous peripheral blood stem cell transplantation. Eight patients have collected stem cells without proceeding with immediate consolidation therapy. After a median follow up of 373 days, median progression free survival and overall survival have not been reached. One year overall survival is 97%. One year progression free survival is 87%. In conclusion, we report a very high response rate with a short course of bortezomib, thalidomide and dexamethasone with an acceptable toxicity profile. Follow up of patients in CR treated without high dose therapy and autologous transplant is in progress. Further studies of this active regimen are warranted.
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Yu, Jiangying, Baozhong Sun, Songshan Zhang, Xiaochang Liu, and Peng Xie. "The Effect of Different Induction Methods on the Structure and Physicochemical Properties of Glycosylated Soybean Isolate Gels." Foods 11, no. 22 (November 11, 2022): 3595. http://dx.doi.org/10.3390/foods11223595.
Повний текст джерелаАнотація:
Soybean protein isolate (SPI), as a full-valued protein, is rich in nutrients, such as amino acids. However, the isolated structure of soybeans makes it difficult to react and thus prepare good gels. In order to further improve the properties of SPIs and to prepare plant-based gels with good performance, this experiment was conducted to prepare maltodextrin glycosylated soybean isolate (MGSI) by the glycosylation of SPI and maltodextrin (MD), and the gels were prepared by thermal induction, transglutaminase (TGase) induction, and TG-MgCl2 co-induction of this glycosylated protein to investigate the effects of different induction methods on the structure and properties of the gels produced by MGSIs. Moreover, the effects of different induction methods on the structure and properties of the gels produced by MGSI were investigated. SDS-PAGE protein electrophoresis, FTIR spectroscopy, and endogenous fluorescence spectroscopy revealed that all three inductions result in the covalent bond cross-linking of MGSI during the gel formation process. Compared with thermal induction, the TGase-induced MGSI secondary structure had a higher content of β-folded structures, increased fluorescence intensity of tertiary structures, and produced a red shift. The gel induced by TGase in collaboration with MgCl2 contains a more β-folded structure and irregular curl and increases the β-turned angle and α-helix content further, the endogenous fluorescence λmax is significantly red-shifted, and the fluorescence intensity increases, demonstrating that the tertiary structure of MGSI unfolds the most, forming multilayered gels with the tightest structures. The three gels were analyzed by rheology and SEM, showing that the TGase-MgCl2 synergistically induced gel had the highest energy-storage modulus G’, viscoelasticity, and water-holding capacity, as well as the densest gel structure. In conclusion, the combined treatment of enzyme and MgCl2 might be an effective way of improving the structure and gel properties of SPI. This study helps to promote the high-value utilization of SPI and the development of plant protein gels.
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Escobar, Christina M., Amos Grünebaum, Eunice Y. Nam, Amber T. Olson, Yuzuru Anzai, Maria Teresa Benedetto-Anzai, Teresa Cheon, Alan Arslan, and W. Spencer McClelland. "Non-adherence to labor guidelines in cesarean sections done for failed induction and arrest of dilation." Journal of Perinatal Medicine 49, no. 1 (January 26, 2021): 17–22. http://dx.doi.org/10.1515/jpm-2020-0343.
Повний текст джерелаАнотація:
AbstractObjectivesIn 2014, the American College of Obstetrics and Gynecology published guidelines for diagnosing failed induction of labor (FIOL) and arrest of dilation (AOD) to prevent cesarean delivery (CD). The objectives of this study were to determine the rate of adherence to these guidelines and to compare the association of guideline adherence with physician CD rates and obstetric/neonatal outcomes.MethodsRetrospective cohort review of singleton primary cesarean deliveries for FIOL and AOD at a single academic institution from 2014 to 2016. Univariate and multivariate analyses were used to compare adherence to the guidelines with physician CD rates and obstetric/neonatal outcomes.ResultsOf the 591 cesarean deliveries in the study, 263 were for failed induction, 328 for AOD and 79% (468/591) were not adherent to the American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine (ACOG/SMFM) guidelines. Of the failed inductions, 82% (215/263) and of the AODs 77% (253/328) were not adherent. There was no difference between adherent and non-adherent CDs with regard to maternal characteristics, or obstetric/neonatal outcomes. Duration of oxytocin use after rupture of membranes, dilation at time of CD, and birth weight were statistically higher in adherent CDs. On multivariate linear regression, physician CD rates were inversely correlated with adherence to ACOG/SMFM guidelines (p<0.0001), gestational age (p=0.007), and parity (p=0.003).ConclusionsOur study shows that physician non-compliance with ACOG guidelines was high. Adherence to these guidelines was associated with lower physician CD rates, without an increase in obstetric or neonatal complications.
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Lalani, Tanya L., Ashley D. Staton, Andrew P. Dalovisio, Laura E. Finn, Ambuga Badari, and Carter Thomas Davis. "A Single Institution Experience of Treating Patients with High Dose Methotrexate for Primary CNS Lymphoma and with Secondary CNS Involvement." Blood 136, Supplement 1 (November 5, 2020): 31–32. http://dx.doi.org/10.1182/blood-2020-141434.
Повний текст джерелаАнотація:
Primary CNS lymphoma is a rare condition, with annual incidence of about 1400 cases in the US. Patients with aggressive systemic lymphomas also have high incidence of CNS involvement, with poor overall prognosis. Use of high dose methotrexate based therapies has substantially altered the outlook for these patients. We present the outcomes data of patients with primary CNS lymphoma and those with secondary CNS involvement treated with high dose methotrexate from a single , FACT accredited academic transplant center. We reviewed patients treated at our center over a 42 month period between Jan 2017- June 2020. There were 19 patients with primary CNS lymphoma and 24 with secondary CNS involvement who received high dose methotrexate. There were equal number of men and women, and were mostly Caucasian. Median age at diagnosis was 60 years. Majority were HIV negative (95%). 3 of the 19 patients had EBV infection at the time of diagnosis. Majority had performance status of ECOG 1 (range: 0-4). 1 patient had CNS lymphoma in the post transplant setting (had bilateral lung transplant). 2 out of 19 patients had concurrent solid organ malignancies. 17 patients (90 %) had newly diagnosed primary CNS lymphoma. 2 patients (10 %) had relapsed disease. Patients received a median of 6 induction treatments (range 1-12) . Majority of patients (17/19) received high dose methotrexate with rituximab. 1 patient received only high dose methotrexate. 1 patient received methotrexate, procarbazine, rituximab and vincristine (R MPV). 5 patients (26%) progressed during induction. There were 7 deaths (37 %) during induction phase. Majority of the deaths occured early during induction. Majority had partial response. 1 patient had complete response . No patient has received stem cell transplant. There were no chemotherapy delays due to COVID 19 . No patient with primary CNS lymphoma was hospitalized or died due to COVID 19. 1 patient elected to defer chemotherapy due to fear of contracting COVID 19 in the hospital. No patient received the full,planned doses of high dose methotrexate during induction. Dose reductions were due to poor performance status or impaired renal function. Consolidation was mainly with high dose methotrexate. Those progressing received whole brain radiation, Ara C , or best supportive care. The PFS and OS are being evaluated at the time of this submission. There were 24 patients with secondary CNS involvement . 12 had concurrent systemic and CNS involvement. 12 patients had history of systemic lymphoma but with CNS only relapse. There were equal males and females. Median age at diagnosis was 64 years. (range 33-81). They had good performance status, with majority having PS of ECOG 1 (range 1-3). Majority were caucasian. There were 4 patients (17%) with EBV infection. 2 patients (8 %) had HIV. They received a median of 2 high dose methotrexate inductions (range: 1-10). 4 patients (17%) eventually received stem cell transplants. PFS, survival data are being evaluated at the time of this submission. In general, high dose methotrexate was well tolerated in both primary CNS lymphoma and systemic lymphoma with CNS involvement. Stem cell transplants are still being done infrequently for these patients. Disclosures Finn: Jazz Pharmaceuticals:Speakers Bureau;Celgene:Speakers Bureau;Seattle Genetics:Speakers Bureau.
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Cazacu, Emil, Lucian Petrescu, and Maria-Cătălina Petrescu. "THE MAJOR PREDICTIVE MAINTENANCE ACTIONS OF THE ELECTRIC EQUIPMENTS IN THE INDUSTRIAL FACILITIES." Scientific Bulletin of Electrical Engineering Faculty 18, no. 1 (April 1, 2018): 26–33. http://dx.doi.org/10.1515/sbeef-2017-0018.
Повний текст джерелаАнотація:
Abstract In modern low-voltage electrical installations, the predictive maintenance of the major electrical equipments involved in the power delivery process (transformers) or in the conversion of the electrical energy (especially electric motors) becomes mandatory. Thus, a high level of reliability and safety is assured for both the electric facility and operators. The proactive maintenance is to be non-invasively performed and mainly requires an infrared (IR) thermographic inspection and power quality analysis of the installation loads. A vibration investigation is also necessary for the motor drive systems. The paper critically studies the first two main maintenance procedures revealing their main characteristics, performances and limits. A case-study presents a 1000 kVA distribution transformer that supplies a bakery facility that comprised mainly heaters and inductions motors as loads.
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WANG, YEN-WEN, PEI-CHANN CHANG, CHIN-YUAN FAN, and CHIUNG-HUA HUANG. "DATABASE CLASSIFICATION BY INTEGRATING A CASE-BASED REASONING AND SUPPORT VECTOR MACHINE FOR INDUCTION." Journal of Circuits, Systems and Computers 19, no. 01 (February 2010): 31–44. http://dx.doi.org/10.1142/s0218126610005950.
Повний текст джерелаАнотація:
Database classification suffers from two common problems, i.e., the high dimensionality and nonstationary variations within the large historic data. This paper presents a hybrid classification model by integrating a case-based reasoning technique, a Support Vector Machine (SVM), and Genetic Algorithms to construct a decision-making system for data classification in various database applications. The model is mainly based on the concept that the historic database can be transformed into a smaller case-base together with a group of SVM models. As a result, the model can more accurately respond to the current data under classifying from the inductions by these SVM models generated from these smaller case bases. Hit rate is applied as a performance measure and the effectiveness of our proposed model is demonstrated by experimentally compared with other approaches on different database classification applications. The average hit rate of our proposed model is the highest among others.
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Jogia, Ashutosh, and Krishna A Mehta. "Use of the Robson classification to assess cesarean section at a medical college hospital in Gujarat, India." Asian Journal of Medical Sciences 13, no. 8 (August 1, 2022): 202–7. http://dx.doi.org/10.3126/ajms.v13i8.44293.
Повний текст джерелаАнотація:
Background: The increasing trends for cesarean section (CS) is not only in India but also globally have been a cause of concern. With the aim of comparing and analyzing CS rates worldwide, the WHO suggests Robson’s ten-group classification system (TGCS). Aims and Objectives: To find the group of women with High CS rate. Which will help policymakers to target that specific groups of women for the reduction of overall CS. Materials and Methods: This was a retrospective study design using hospital records for women delivered between December 1, 2020, and November 30, 2021. Data were entered and analyzed using Excel 2019 and presented in percentages after using Robson’s TGCS. Results: Out of total 5514 women delivered during the study period, 2262 (41.02%) were delivered by CS. Group 1 and Group 2 included a total of 41.49% of women in the present study. The high CS rates were in Group 9 (abnormal lie) – 100%, Group 5 (previous CS) – 97.35%, and Group 6 (breech, nulliparous) – 77.47%. In all CS, the maximum contribution was done by Group 5 (37.36%) and Group 2 (28.47%). Conclusions: The result indicates that Group 5 women with previous CS and Group 2 women with induced labor contributed the maximum to overall CS rates. Trial of labor after CS should be used as a routine. The specific guideline should be followed about the time and cause for induction of labor to decrease the CS rate that occurs due to failed inductions. To monitor CS rate and take actions accordingly, Robson’s TGCS should be used in all health facilities where delivery is done.
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Honma, Kazue, Kazuki Mochizuki, and Toshinao Goda. "Inductions of histone H3 acetylation at lysine 9 on SGLT1 gene and its expression by feeding mice a high carbohydrate/fat ratio diet." Nutrition 25, no. 1 (January 2009): 40–44. http://dx.doi.org/10.1016/j.nut.2008.07.006.
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Dobronravov, Vladimir A., Olga B. Bystrova, Zinaida Sh Kochoyan, and Evgeniya N. Fomicheva. "A novel approach to rapid induction of remission in primary membranous nephropathy." Terapevticheskii arkhiv 93, no. 6 (June 15, 2021): 706–12. http://dx.doi.org/10.26442/00403660.2021.06.200865.
Повний текст джерелаАнотація:
Aim. То evaluate the effectiveness of a novel multi-targeted treatment approach including rituximab (RTX), cyclophosphamide (CPH) and steroids (S) to the induction of remission in patients with primary membranous nephropathy (PMN) compared to standard immunosuppression (IST).
Materials and methods. An open-label prospective comparative study included 56 PMN patients (pts) with nephrotic syndrome (NS) and high serum level of antibodies to the phospholipase A2 receptor anti-PLA2R (mean age 5112 years, men 70%). We recorded demographic and clinical parameters at the time of kidney biopsy, data from light-optical and immunomorphological studies. All pts were on stable doses of the renin-angiotensin systems blockers. We compared the effectiveness of different treatments in the inductions of clinical and immunological remissions in pts who received experimental treatment with RTX, CPH and S (RTX+CPH+S group, n=14) and two control groups: high-dose RTX therapy (group RTX, n=12), cyclosporine and steroids (group CsA+S, n=30).
Results. In the RTX+CPH+S group, remission was achieved in 100% of cases (of which complete remissions CR in 21.4%). The median time-to-remission (2.5 [1.0; 3.5] months) was significantly lower compared to both control groups: RTX (8.7 [6.6; 14.0] months, p=0.005) and CsA+S (12.4 [6.5; 19.9] months, p0.001). The cumulative incidence of clinical and immunological remissions was also significantly higher in the RTX+CPH+S group than in the control groups. These results were confirmed in comparative analyzes in the same treatment groups after propensity score matching. The cumulative incidence of clinical and immunological remissions in the RTX+CPH+S group was higher than in the combined group of patients who received other therapies (p0.001). The incidence of serious adverse events was low and did not differ between groups.
Conclusion. The use of multi-targeted therapy with rituximab, cyclophosphamide, and steroids seems to be an effective approach for the rapid induction of PMN remission and prevention of NS complications.
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Zahn-Waxler, Carolyn, Pamela M. Cole, Jean Darby Welsh, and Nathan A. Fox. "Psychophysiological correlates of empathy and prosocial behaviors in preschool children with behavior problems." Development and Psychopathology 7, no. 1 (1995): 27–48. http://dx.doi.org/10.1017/s0954579400006325.
Повний текст джерелаАнотація:
AbstractThis study focused on empathic and prosocial orientations in preschool children who vary in externalizing problems. Children were categorized as low, moderate, or high risk for developing disruptive behavior disorders, depending on severity of current behavior problems. Hypothetical and real encounters with others in distress were used to examine children's affect, behavior, autonomic activity, and social cognitions. When children witnessed someone in distress, empathic concern and prosocial behaviors were present at similar levels for all risk groups. However, moderate and high-risk children were less able than low-risk children to remain positively engaged with distress victims. Girls showed more prosocial behavior than boys, and boys showed more anger than girls. During sadness mood inductions to assess autonomic activity, risk groups did not differ on heart rate or vagal tone. Girls showed higher skin conductance than boys, with high-risk girls showing the highest levels. Higher heart rate (and heart rate deceleration) predicted empathic concern and prosocial behavior, whereas lower heart rate was associated with aggression and avoidance, irrespective of risk. Although biological correlates of emotions and behaviors that reflect caring versus indifference to others' distress are identified, they do not support an early direct link to externalizing psychopathologies.
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Roy, René, та Allan W. Rey. "Controlled diastereoselection in 2-lithio-1,3-dithiane additions onto α-substituted γ-lactols. Model studies toward bryostatins from (R)-pantolactone". Canadian Journal of Chemistry 69, № 1 (1 січня 1991): 62–69. http://dx.doi.org/10.1139/v91-009.
Повний текст джерелаАнотація:
Homochiral α-substituted γ-lactols 3 and 4 derived from (R)-pantolactone 1 were used in 2-lithio-1,3-dithiane additions to afford very high controls in diastereoselectivities arising from 1,2-asymmetric inductions. Thus non-chelation controlled nucleophilic addition on 3 gave the anti diastereomer 5 as the major product (92% de), while the chelation controlled addition on 4 furnished the syn diastereomer 7 (96% de) as the almost exclusive product. The stereochemical outcomes of these reactions were proven unambiguously by locking the conformation of the syn- and anti-triol adducts 7 and 8 through their respective acetonides and by nuclear Overhauser enhancement measurements. The lack of 1,3-dioxolane formation in the case of the anti-triol 8 was taken as a further confirmation of the absolute configuration at the newly created stereocenter. Key words: byrostatin, pantolactone, α-hydroxylactol, dithiane.
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Vidal, Liat, Anat Gafter-Gvili, Gilles Salles, Martin H. Dreyling, Michele Ghielmini, Shu-Fang Hsu Schmitz, Ruth Pettengell, Mathias Witzens-Harig, and Ofer Shpilberg. "Rituximab maintenance for the Treatment of patients with Follicular Lymphoma: Systematic Review and Meta-Analysis of Randomized Trials - 2010 Update." Blood 116, no. 21 (November 19, 2010): 1798. http://dx.doi.org/10.1182/blood.v116.21.1798.1798.
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Abstract Abstract 1798 Rituximab maintenance for the treatment of patients with follicular lymphoma: systematic review and meta-analysis of randomized trials - 2010 update. Liat Vidal, Anat Gafter-Gvili, Gilles Salles, Martin Dreyling, Michele Ghielmini, Shu-Fang Hsu Schmitz, Ruth Pettengell, Mathias Witsenz-Harig, Ofer Shpilberg. Follicular lymphoma (FL) is characterized by slow growth and an initially high rate of response to treatment, but patients typically relapse and experience progressive disease. Rituximab in combination with chemotherapy has been shown to improve overall survival (OS) in patients with FL compared with chemotherapy alone. In order to evaluate the effect of maintenance treatment with rituximab on the OS of patients with FL we performed a systematic review and meta-analysis in 2007. Updated results from these studies and new clinical trials are reported here. Methods: A systematic review and meta-analysis of randomized controlled trials that compared rituximab maintenance therapy with observation or treatment at relapse (no maintenance therapy). In June 2010 we updated our 2007 search in The Cochrane Library, MEDLINE, LILACS, conference proceedings, and databases of ongoing trials. Two reviewers independently assessed the quality of the trials and extracted data. HRs for time-to-event data were estimated and pooled. Results: The search in 2007 identified five eligible trials including 1143 adult patients. The results of the meta-analysis of 985 patients with FL were previously reported. The present search identified six additional included trials; three of them had no current available outcome data. Three of the trials that were included in our first report had long term outcomes that were available for the current meta-analysis. Patients treated with maintenance rituximab had statistically significant better OS compared to patients in the observation arm or patients treated at relapse (HR for death 0.75, 95% confidence interval (CI) 0.61 to 0.91, 2283 patients, Figure). Patients with refractory or relapsed (i.e., previously treated) FL had a significant survival benefit with maintenance rituximab therapy (HR for death 0.72, 95% CI 0.57 to 0.91, 909 patients), whereas previously untreated patients did not (HR for death 0.83, 95% CI 0.56 to 1.23, 1374 patients). Progression free survival was improved in each of the included trials, pooled HR 0.54 95% CI 0.48 to 0.61, n=2283. This effect was consistent both in patients who received rituximab maintenance after their first induction therapy (HR 0.53, 95% CI 0.44 to 0.63, n=1374), and in those who received maintenance rituximab after two or more inductions (HR 0.63, 95% CI 0.50 to 0.79, n=804), and following different induction therapies: rituximab alone (HR 0.54, 95% CI 0.40 to 0.73, n=240), chemotherapy alone (HR 0.49, 95% CI 0.37 to 0.66, n=308), and rituximab-chemotherapy (HR 0.58, 95% CI 0.48 to 0.70, n=1352). The rate of infection-related adverse events was higher with rituximab maintenance treatment (Risk ratio (RR) 1.99, 95% CI 1.21 to 3.27). The rate of grade 3/4 adverse events was higher with rituximab maintenance (RR 1.47 95% CI 1.19 to 1.83). Conclusions: Rituximab maintenance improves OS and disease control in patients with FL after a successful induction therapy. The accumulating data from new and updated clinical trials did not change the results of our former meta-analysis. While a clear survival benefit is shown only for patients with relapsed or refractory FL, progression free survival is improved after first induction as well as after two or more inductions. Disclosures: Salles: Roche: Honoraria. Dreyling:Roche: . Ghielmini:Roche: Consultancy. Pettengell:Roche: Consultancy, Honoraria. Shpilberg:Roche: Consultancy.
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Rath, Werner, Patrick Stelzl, and Sven Kehl. "Outpatient Induction of Labor – Are Balloon Catheters an Appropriate Method?" Geburtshilfe und Frauenheilkunde 81, no. 01 (January 2021): 70–80. http://dx.doi.org/10.1055/a-1308-2341.
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AbstractAs the number of labor inductions in high-income countries has steadily risen, hospital costs and the additional burden on obstetric staff have also increased. Outpatient induction of labor is therefore becoming increasingly important. It has been estimated that 20 – 50% of all pregnant women requiring induction would be eligible for outpatient induction. The use of balloon catheters in patients with an unripe cervix has been shown to be an effective and safe method of cervical priming. Balloon catheters are as effective as the vaginal administration of prostaglandin E2 or oral misoprostol. The advantage of using a balloon catheter is that it avoids uterine hyperstimulation and monitoring is less expensive. This makes balloon catheters a suitable option for outpatient cervical ripening. Admittedly, intravenous administration of oxytocin to induce or augment labor is required in approximately 75% of cases. Balloon catheters are not associated with a higher risk of maternal and neonatal infection compared to vaginal PGE2. Low-risk pregnancies (e.g., post-term pregnancies, gestational diabetes) are suitable for outpatient cervical ripening with a balloon catheter. The data for high-risk pregnancies are still insufficient. The following conditions are recommended when considering an outpatient approach: strict selection of appropriate patients (singleton pregnancy, cephalic presentation, intact membranes), CTG monitoring for 20 – 40 minutes after balloon placement, the patient must be given detailed instructions about the indications for immediate readmission to hospital, and 24-hour phone access to the hospital must be ensured. According to reviewed studies, the balloon catheter remained in place between 12 hours (“overnight”) and 24 hours. The most common reason for readmission to hospital was expulsion of the balloon catheter. The advantages of outpatient versus inpatient induction of cervical ripening with a balloon catheter were the significantly shorter hospital stay, the lower costs, and higher patient satisfaction, with both procedures having been shown to be equally effective. Complication rates (e.g., vaginal bleeding, severe pain, uterine hyperstimulation syndrome) during the cervical ripening phase are low (0.3 – 1.5%); severe adverse outcomes (e.g., placental abruption) have not been reported. Compared to inpatient induction of labor using vaginal PGE2, outpatient cervical ripening using a balloon catheter had a lower rate of deliveries/24 hours and a significantly higher need for oxytocin; however, hospital stay was significantly shorter, frequency of pain during the cervical ripening phase was significantly lower, and patientsʼ duration of sleep was longer. A randomized controlled study comparing outpatient cervical priming with a balloon catheter with outpatient or inpatient induction of labor with oral misoprostol would be of clinical interest.
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Bouligny, Ian M., and Keri R. Maher. "Outcomes of High-Intensity Versus Low-Intensity Induction in Elderly Patients with AML: A Retrospective Analysis of Real-World Outcomes." Blood 138, Supplement 1 (November 5, 2021): 4386. http://dx.doi.org/10.1182/blood-2021-153526.
Повний текст джерелаАнотація:
Abstract Background: The optimal induction strategy for patients with acute myeloid leukemia (AML) older than 65 years remains unknown. The use of lower intensity therapies in this population has become routine. The inclusion of venetoclax to intensify a hypomethylating agent backbone has efficacy outcomes approaching those of anthracycline-based inductions in elderly adults. This retrospective analysis sought to compare venetoclax-based induction combinations to anthracycline-based regimens. Patients & Methods: We retrospectively analyzed all patients with AML older than 65 treated with 7+3 or liposomal daunorubicin and cytarabine (CPX-351) versus venetoclax with either decitabine or azacitidine from June 2018 to December 2020 at our institution. Patients were included in the analysis only if ECOG performance status prior to induction supported intensive induction (≤2). Baseline patient demographics, cytogenetic risk, molecular profiling (through next-generation sequencing), toxicity, responses, and MRD analysis were obtained. Kaplan-Meier curves were constructed using censoring at date of last contact for those that did not have a death event in the specified time period. Results: The intensive cohort included 28 patients, 15 (53.6%) males and 13 (46.4%) females. The median age at diagnosis was 69 (range: 65 - 76), the median ECOG score was 1, and the median CCI score was 6. The anthracycline in the 7+3 cohort was daunorubicin in 15 patients (53.6%) and idarubicin in 1 (3.6%) patient. This cohort also included 12 (42.9%) patients treated with CPX-351. Two (7.1%) patients had favorable cytogenetics, 6 (21.4%) had intermediate cytogenetics, and 20 (71.4%) had adverse cytogenetics. The most common non-hematological toxicities that Grade 1 or higher were neutropenic fever (85.7%), infection (71.4%), GI/hepatobiliary (42.9%), cardiovascular (35.7%), and acute kidney injury (32.1%). One (3.8%) of the 26 evaluable patients died within 30 days and one (3.8%) died within 60 days. Fourteen patients (50.0%) achieved CR and 3 (10.7%) achieved CRi for an ORR of 60.7%. Six of the 17 patients with CR or CRi were analyzed for MRD and two (33.3%) were MRD-negative. Six (21.4%) received an allogenic stem cell transplant (SCT). The median OS in the intensive cohort was not reached at a median follow-up of 711 days (23.4 months). The lower intensity cohort totaled 28 patients, 18 (64.3%) males and 10 (35.7%) females. The median age at diagnosis was 75 (range: 65 - 85), median ECOG score was 1, and the median CCI score was 6. There were no differences in ECOG score (p = 0.930), CCI (p = 0.195), or cytogenetic risk (p = 0.924) between the two groups. Venetoclax was given in combination with 5-day decitabine (78.6%) or azacitidine (21.4%). Of the 28 patients with evaluable cytogenetics, 2 (7.1%) were favorable, 5 (17.9%) were intermediate, and 19 (67.9%) were adverse. The most common non-hematological toxicities were infection (57.1%), neutropenic fever (50.0%), GI/hepatobiliary (28.5%), cardiovascular (25.0%), and acute kidney injury (21.4%). Of the 28 evaluable patients, one (3.6%) died within 30 days and 7 (25.0%) died within 60 days, though not statistically significant compared to the intensive group (p = 0.103). Two (7.1%) achieved CR and 12 (39.3%) achieved CRi for an ORR of 46.4%. Two of the 13 patients were evaluated for MRD and none were MRD-negative after induction. Two (7.1%) patients received allogeneic SCT. The median OS in the venetoclax cohort was 354 days (11.6 months), though no statistically significant difference was detected when compared to the intensive cohort (p = 0.0735). However, when the two cohorts were selected for adverse cytogenetic risk and compared, the median OS was not reached in the intensive group at a median follow-up of 636 days but was 91 days in the venetoclax group (p = 0.025). Conclusion: Elderly patients had superior responses and survival to intensive induction when compared to venetoclax-based strategies when analyzed with respect to cytogenetic risk. Additionally, though the rates of toxicities were higher in the intensive cohort, the mortality during induction appeared to be lower, but did not reach statistical significance. Our work indicates that careful selection of intensive induction candidates is warranted, as those who can tolerate intensive regimens may be undertreated by selecting a less-intensive therapeutic strategy. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.
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Keng, Shian-Ling, and Hui Han Tan. "Effects of brief mindfulness and loving-kindness meditation inductions on emotional and behavioral responses to social rejection among individuals with high borderline personality traits." Behaviour Research and Therapy 100 (January 2018): 44–53. http://dx.doi.org/10.1016/j.brat.2017.11.005.
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Poh, Christina, Ebaa Alobeidi, Joseph Tuscano, Aaron S. Rosenberg, Rasmus T. Hoeg, and Brian A. Jonas. "Complications in Acute Myeloid Leukemia Inductions Prior to Count Recovery: A Feasibility Study for Outpatient Care at an Academic Center." Blood 136, Supplement 1 (November 5, 2020): 28. http://dx.doi.org/10.1182/blood-2020-136333.
Повний текст джерелаАнотація:
Introduction Adults with newly diagnosed acute myeloid leukemia (AML) who receive intensive remission induction typically remain hospitalized until blood count recovery due to the high risk of infection and bleeding related to pancytopenia. This usually translates into at least 4 weeks of hospitalization, which can lead to reduced quality of life, increased risk of nosocomial infections, significant resource utilization and economic burden. Previous studies conducted at academic centers with large AML populations have suggested that outpatient management following induction chemotherapy is feasible and safe with close follow-up. These studies may have limited generalizability based on exceptional outpatient resources. Thus, this practice has not been widely adopted. To assess the feasibility of early patient discharge at our academic center which provides care for a smaller AML population, where we have a 6-days per week infusion center and hospitalize all AML patients undergoing induction until count recovery, we conducted a retrospective analysis of complications prior to blood count recovery in this patient population. Methods We identified patients ≥18 years with newly diagnosed non-APL AML admitted to the University of California, Davis Medical Center from 1/1/14 to 1/1/19 who received induction chemotherapy with cytarabine/daunorubicin (7+3) or a regimen of similar intensity with first interim bone marrow biopsy showing hypocellularity with <5% blasts. Endpoints included the rate of complete remission, infectious and hemorrhagic complications, transfusions, ICU transfers and death. We grouped timing of complications as those observed prior to and on or after day 15 of induction therapy until discharge. Patients who received a second induction regimen were censored at time of the start of the second regimen. Results Overall, 50 patients were identified; 42 (84%) received 7+3, 3 (6%) received FLAG and 5 (10%) received liposomal daunorubicin-cytarabine induction. Median age was 56 (range 25-81) years. ELN 2017 favorable, intermediate and adverse risk disease was observed in 18 (36%), 20 (40%) and 12 (24%) patients, respectively. Forty-nine (98%) patients with a negative interim marrow achieved a complete remission with first induction therapy. Forty-five (90%) patients had infectious complications at any time (Table 1), with 34 (68%) having infectious complications occurring prior to day 15 of induction. All patients with culture negative neutropenic fever prior to day 15 of induction as their only infectious complication had no further infectious complications throughout hospitalization although all received IV antibiotics until count recovery. Ten (20%) patients had hemorrhagic complications at any time (Table 1), with 9 (18%) having hemorrhagic complications occurring between day 15 of induction and discharge. Median platelet transfusion volume between days 15-21 and 22-discharge was 3.5 (range 1-18) and 0 (range 0-15) units, respectively. Three (6%) patients required ICU transfer. All ICU transfers occurred after day 14 of induction. One patient had hypoxic respiratory failure on admission and required transfer back to the ICU. Death prior to marrow recovery was observed in 1 patient (2%) due to subdural hemorrhage. Conclusion Intensive remission induction in hospitalized patients with newly diagnosed AML is associated with good efficacy and safety outcomes for patients with blast clearance on interim bone marrow biopsy. Although the rate of infectious complications was high, the majority debuted early during hospitalization and the rate of ICU transfers was low. All patients with culture negative neutropenic fever prior to day 15 of induction as their sole infectious complication who were treated with IV antibiotics had no further infectious complications throughout hospitalization. Hemorrhagic complications more commonly occurred later during hospitalization, although platelet transfusion requirements were manageable after day 15 of induction. These data suggest that at our institution, select patients receiving intensive remission induction and without infectious complications could be considered for early discharge and close outpatient follow-up after interim bone marrow biopsy showing hypoplasia. A prospective early discharge study to confirm these findings is being developed. Disclosures Poh: Acrotech: Honoraria. Tuscano:Spectrum: Research Funding; Novartis: Research Funding; Celgene: Honoraria, Research Funding; Amgen: Honoraria; Takeda: Research Funding; Abbvie: Research Funding; Genentech: Research Funding; Pharmacyclics: Research Funding; Seattle Genetics: Honoraria. Rosenberg:Takeda: Speakers Bureau; Janssen: Speakers Bureau; Amgen: Membership on an entity's Board of Directors or advisory committees; Seattle Genetics: Membership on an entity's Board of Directors or advisory committees. Jonas:Forma: Research Funding; F. Hoffmann-La Roche: Research Funding; Daiichi Sankyo: Research Funding; AROG: Research Funding; Accelerated Medical Diagnostics: Research Funding; Forty Seven: Research Funding; Jazz: Consultancy, Research Funding; Sigma Tau: Research Funding; Hanmi: Research Funding; Genentech/Roche: Research Funding; Pharmacyclics: Research Funding; Celgene: Consultancy, Research Funding; GlycoMimetics: Consultancy, Other: TRAVEL, ACCOMMODATIONS, EXPENSES (paid by any for-profit health care company), Research Funding; Treadwell: Consultancy; Tolero: Consultancy; Takeda: Consultancy; Pfizer: Research Funding; LP Therapeutics: Research Funding; Incyte: Research Funding; Amgen: Consultancy, Other: TRAVEL, ACCOMMODATIONS, EXPENSES (paid by any for-profit health care company), Research Funding; AbbVie: Consultancy, Other: TRAVEL, ACCOMMODATIONS, EXPENSES (paid by any for-profit health care company), Research Funding.
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Parveen, Shehla, Muntaha Hanif, and Naheed Akhtar. "Determine the Rate of Harmful Maternal and Foetal Outcomes in Pregnant Adolescents." Pakistan Journal of Medical and Health Sciences 16, no. 4 (April 29, 2022): 1230–32. http://dx.doi.org/10.53350/pjmhs221641230.
Повний текст джерелаАнотація:
Objective: The purpose of this research is to examine whether or not adolescent pregnant women have adverse maternal and foetal outcomes. Study Design: Randomized controlled trial Place and Duration: The study was conducted at Gynaecology department of DHQ Teaching Hospital, Sargodha and DHQ Hospital Mianwali for duration of four months from August 2021 to November 2021. Material and Methods: In all, there were 84 participants in this research. Patients were between the ages of 14 and 45 years. After obtaining written agreement from patients, demographic data was collected. The patients were split into two groups, I and II, which were evenly distributed. Group I included 42 patients between the ages of 14 and 19, and Group II included 42 patients between the ages of 19 and over. Cesarean sections, instrumental deliveries, labour inductions and labour prolongations, hypertensive disorders, and other negative results were observed for the two cohorts. High rates of perinatal death and admission to the neonatal intensive care unit (NICU) were also found. SPSS 20.0 was used to analyse all of the data. Results: In group I mean age of the patients was 16.65±8.51 years and had mean BMI 20.05±6.33 Kg/m2 while in second group the mean age was 23.15±6.22 years and had mean BMI 24.7±9.51 Kg/m2. Study participants in adolescence (I) were more likely to have unfavourable foetal (perinatal death, low birth weight and low apgar score) and mother outcomes (C-section, Instrumental delivery, induction of labour, and prolonged labour) than those in the adult group (II). Conclusion: According to this research, premature neonatal critical care unit admissions and delayed intrauterine development are both on the increase. Pregnant teenagers are more likely to suffer from anaemia, a urinary tract infection, high blood pressure pregnancy, and a need for a surgical birth. Keywords: Maternal outcome, Partum haemorrhage, Fetal outcome, Pre-eclampsia,
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Puchý, V., F. Kováč, P. Hvizdoš, I. Petryshynets, and M. Sopko. "Effect of Fiber Laser Treating on Magnetic Domains in the Grain-Oriented Silicon Steel: Imaging Domains by Bitter, MFM and Kerr Microscopy." High Temperature Materials and Processes 35, no. 7 (August 1, 2016): 739–44. http://dx.doi.org/10.1515/htmp-2014-0166.
Повний текст джерелаАнотація:
AbstractA magnetic domain laser scribing technique of grain-oriented 3.2% silicon steel has been investigated for the direct influencing on the magnetic domain wall. The magneto-optical Kerr effect was employed to obtain a visible contrast between antiparallel domains. The effects of laser treating on domain wall were observed. The Bitter, MFM and Kerr microscope pictures showed that domain-wall positions did not repeat precisely from cycle to cycle, particularly at high inductions, and that the average domain-wall spacing decreased with increasing density of laser scribing lines. Two phenomena have been discovered that are difficult to explain (1) that the hardness decreases with increasing laser energy and (2) that the coercivity decreases with decreasing laser energy. A semi-quantitative relationship has been found between the domain patterns and used fiber laser treating method. The behavior of patterns in an applied magnetic field is shown, and based on that a two-dimensional laser lines configuration is proposed for one of the less complicated surface patterns.
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Altheimer, Gizem, and Heather L. Urry. "Do Emotions Cause Eating? The Role of Previous Experiences and Social Context in Emotional Eating." Current Directions in Psychological Science 28, no. 3 (April 9, 2019): 234–40. http://dx.doi.org/10.1177/0963721419837685.
Повний текст джерелаАнотація:
Emotional eating is defined as an increase in eating following negative emotion. Self-reported emotional eating has been associated with physical-health concerns. However, experimental studies indicate that negative-mood inductions do not reliably lead to increased eating in healthy eaters, not even among those with a high desire to eat when emotional. We argue that experimental studies will help us understand emotional eating only if they account for the following ideas: (a) Emotional eating may require that people learn to associate emotion with eating, (b) emotional eating may follow only specific discrete emotions, and (c) emotional eating may depend on social context. Each of these points suggests a fruitful direction for future research. Specifically, future studies must acknowledge, identify, and account for variations in the extent to which people have learned to associate emotions with eating; assess or elicit strong discrete emotions; and systematically examine the effect of social context on emotional eating.
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Nagler, Arnon, Jacques-Emmanuel Galimard, Myriam Labopin, Didier Blaise, William Arcese, Depei Wu, Gwendolyn Van Gorkom, et al. "Long-Term Outcome of Peripheral Blood Autologous Stem Cell Transplantation (AutoSCT) for De Novo Acute Myeloid Leukemia in Patients Achieving First Complete Remission after One Vs Two Induction Courses: A Study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT)." Blood 138, Supplement 1 (November 5, 2021): 1840. http://dx.doi.org/10.1182/blood-2021-145031.
Повний текст джерелаАнотація:
Abstract Background: Achieving a first complete remission (CR1) is the primary goal in the treatment of AML and is an important prognostic factor for transplantation outcome in general and even more so for autologous transplantation (AutoSCT). However, there are no data for AutoSCT indicating whether the number of chemotherapy courses (1 vs 2) needed to achieve CR1 is of prognostic significance for transplantation outcome. Methods: Using the EBMT/ALWP registry, we compared transplantation outcomes of adult patients (pts) aged ≥18 years with de novo AML that underwent a peripheral blood AutoSCT in 2000-2019 in CR1 achieved following one vs two chemotherapy courses. The primary outcome was the Leukemia Free Survival (LFS). Multivariate analysis (MVA) adjusting for differences between the groups and knowns factors were performed using Cox's proportional- hazards regression model for outcomes. Results: 1825 pts were included: 1532 (84%) with one and 293 (16%) with two induction chemotherapies courses. Time from diagnosis to AutoSCT was 4.7 (3.9-5.8) vs 5.7 (4.7-7.1) months, respectively (p<0.001). Median follow-up was 7.9 (95% CI: 7.4-8.4) and 7.7 (95% CI: 7.0-8.6) years, respectively (p=0.8). Median year of transplant was 2005 (2002-2009) and 2004 (2002-2007), respectively (p<0.001). Median age was 49 (38-57) and 47 (36 -56) years (p=0.06); 54% and 57 % of both groups were male, (p=0.35). Cytogenetic risk as defined by the Medical Research Council (MRC) classification, differed significantly between the two induction groups (p<0.001). Patients with one induction had a higher percentage of favorable-risk than those with two inductions (18% vs 14%), and a lower percentage of adverse-risk cytogenetics (6% vs 13%), while 76% and 73%, respectively, had intermediate-risk cytogenetics (missing data-11percentage). Karnofsky performance score (KPS) > 90 was higher in pts receiving 1 vs 2 inductions, 71% and 58% of pts, respectively (p<0.001). The most frequent conditioning regimen for both groups was Busulfan (Bu) /Cytoxan (Cy) 50% vs 45% and Bu / Melphalan (Mel) 17% and 19%, respectively, for induction groups 1 and 2, respectively. Day 30 neutrophil engraftment incidence was 96% and 96.5%. Five -year non-relapse mortality (NRM) was 6.2% vs 6.0% for pts achieving CR1 with 2 vs 1 chemotherapy courses, respectively, and did not differ significantly (HR=1.31 (95% CI: 0.81-2.10), p=0.27). Five -year relapse incidence (RI) was higher :67.2% vs 52.3%, (HR=1.46 (95% CI: 1.25-1.72), p<0.001), while LFS and overall survival (OS) were lower for pts achieving CR1 with 2 vs 1 course of chemotherapy: 26.6% vs 41.7% (HR= 1.42 (95% CI: 1.22-1.66), p<0.001) and 36.2% vs 53.3%, (HR=1.48 (95% CI: 1.25-1.75), p<0.001), respectively (Figure). Other significant prognostic factors in MVA were adverse- compared to good risk cytogenetics and older age (per 10 years) for all AutoSCT outcome parameters including RI, NRM, LFS and OS; intermediate compared to good risk cytogenetics for RI, LFS and OS; female gender for RI and LFS ;and year of transplant for RI and OS. Conclusions: The five -year RI was higher and transplantation outcomes significantly inferior in pts with AML undergoing AutoSCT but who received two lines of chemotherapy to achieve CR1. Such pts may benefit from additional novel therapies in the conditioning or post-AutoSCT or be considered for allogeneic transplantation in an attempt to reduce their high RI and improve outcomes. Figure 1 Figure 1. Disclosures Labopin: Jazz Pharmaceuticals: Honoraria. Blaise: Jazz Pharmaceuticals: Honoraria. Huynh: Jazz Pharmaceuticals: Honoraria. Mohty: Takeda: Honoraria; Jazz: Honoraria, Research Funding; Astellas: Honoraria; Janssen: Honoraria, Research Funding; Bristol Myers Squibb: Honoraria; Novartis: Honoraria; Celgene: Honoraria, Research Funding; Amgen: Honoraria; Gilead: Honoraria; Pfizer: Honoraria; Adaptive Biotechnologies: Honoraria; Sanofi: Honoraria, Research Funding. Pigneux: Amgen: Consultancy; Sunesis: Consultancy, Research Funding; BMS Celgene: Consultancy, Research Funding; Roche: Consultancy, Research Funding; Novartis: Consultancy, Research Funding.
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Kessler, Jan H., Nico J. Beekman, Sandra A. Bres-Vloemans, Pauline Verdijk, Peter A. van Veelen, Antoinette M. Kloosterman-Joosten, Debby C. J. Vissers, et al. "Efficient Identification of Novel Hla-A*0201–Presented Cytotoxic T Lymphocyte Epitopes in the Widely Expressed Tumor Antigen Prame by Proteasome-Mediated Digestion Analysis." Journal of Experimental Medicine 193, no. 1 (January 1, 2001): 73–88. http://dx.doi.org/10.1084/jem.193.1.73.
Повний текст джерелаАнотація:
We report the efficient identification of four human histocompatibility leukocyte antigen (HLA)-A*0201–presented cytotoxic T lymphocyte (CTL) epitopes in the tumor-associated antigen PRAME using an improved “reverse immunology” strategy. Next to motif-based HLA-A*0201 binding prediction and actual binding and stability assays, analysis of in vitro proteasome-mediated digestions of polypeptides encompassing candidate epitopes was incorporated in the epitope prediction procedure. Proteasome cleavage pattern analysis, in particular determination of correct COOH-terminal cleavage of the putative epitope, allows a far more accurate and selective prediction of CTL epitopes. Only 4 of 19 high affinity HLA-A*0201 binding peptides (21%) were found to be efficiently generated by the proteasome in vitro. This approach avoids laborious CTL response inductions against high affinity binding peptides that are not processed and limits the number of peptides to be assayed for binding. CTL clones induced against the four identified epitopes (VLDGLDVLL, PRA100–108; SLYSFPEPEA, PRA142–151; ALYVDSLFFL, PRA300–309; and SLLQHLIGL, PRA425–433) lysed melanoma, renal cell carcinoma, lung carcinoma, and mammary carcinoma cell lines expressing PRAME and HLA-A*0201. This indicates that these epitopes are expressed on cancer cells of diverse histologic origin, making them attractive targets for immunotherapy of cancer.