Дисертації з теми "High Content Imaging Analysis"
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Alibhai, Dominic. "Fluorescence lifetime imaging applied to multiwell plate FRET assays for high content analysis." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/40284.
Повний текст джерелаMclay, Colin Anthony. "A distributed imaging framework for the analysis and visualization of multi-dimensional bio-image datasets, in high content screening applications." Thesis, Kingston University, 2015. http://eprints.kingston.ac.uk/35863/.
Повний текст джерелаMakovoz, Gennadiy. "Latent Semantic Analysis as a Method of Content-Based Image Retrieval in Medical Applications." NSUWorks, 2010. http://nsuworks.nova.edu/gscis_etd/227.
Повний текст джерелаDatar, Akshata. "HIGH CONTENT IMAGING ASSAYS ON MICROARRAY CHIP BASED PLATFORM." Cleveland State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1462795576.
Повний текст джерелаGoode, Ashley Harford. "High resolution ultrasonic imaging system." Thesis, University of Portsmouth, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329278.
Повний текст джерелаJacques, Richard. "Statistical analysis of high content screening data." Thesis, University of Sheffield, 2009. http://etheses.whiterose.ac.uk/2220/.
Повний текст джерелаChaipraparl, Pornpun. "Thai High School Compute Literacy: A Content Analysis." Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc330995/.
Повний текст джерелаWang, Yalin. "Document analysis : table structure understanding and zone content classification /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/6079.
Повний текст джерелаWang, Peng. "High resolution imaging and analysis using aberration-corrected stem." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433775.
Повний текст джерелаMunoz, Antonio. "High performance platform independent content analysis for network processing." Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.602692.
Повний текст джерелаWildenhain, Jan. "Application of multivariate statistics and machine learning to phenotypic imaging and chemical high-content data." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25665.
Повний текст джерелаDietz, Yasmin [Verfasser]. "Etablierung eines high-content-imaging-basierten in-vitro-Testsystems zur Evaluierung genotoxischer Substanzen / Yasmin Dietz." Mainz : Universitätsbibliothek Mainz, 2014. http://d-nb.info/1050054040/34.
Повний текст джерелаKelly, Douglas James. "An automated fluorescence lifetime imaging multiwell plate reader : application to high content imaging of protein interactions and label free readouts of cellular metabolism." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/29131.
Повний текст джерелаLeuchowius, Karl-Johan. "High Content Analysis of Proteins and Protein Interactions by Proximity Ligation." Doctoral thesis, Uppsala universitet, Molekylära verktyg, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-119530.
Повний текст джерелаBergström, Simon, and Oscar Ivarsson. "Automation of a Data Analysis Pipeline for High-content Screening Data." Thesis, Linköpings universitet, Medie- och Informationsteknik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122913.
Повний текст джерелаNyström, Daniel. "High Resolution Analysis of Halftone Prints : A Colorimetric and Multispectral Study." Doctoral thesis, Linköpings universitet, Digitala Medier, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-15888.
Повний текст джерелаMuckli, Lars. "Emergence of visual content in the human brain investigations of amblyopia, blindsight and high-level motion perception with fMRI /." Aachen : Maastricht : Shaker ; University Library, Maastricht University [Host], 2002. http://arno.unimaas.nl/show.cgi?fid=7138.
Повний текст джерелаCao, Hongfei. "High-throughput Visual Knowledge Analysis and Retrieval in Big Data Ecosystems." Thesis, University of Missouri - Columbia, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=13877134.
Повний текст джерелаVisual knowledge plays an important role in many highly skilled applications, such as medical diagnosis, geospatial image analysis and pathology diagnosis. Medical practitioners are able to interpret and reason about diagnostic images based on not only primitive-level image features such as color, texture, and spatial distribution but also their experience and tacit knowledge which are seldom articulated explicitly. This reasoning process is dynamic and closely related to real-time human cognition. Due to a lack of visual knowledge management and sharing tools, it is difficult to capture and transfer such tacit and hard-won expertise to novices. Moreover, many mission-critical applications require the ability to process such tacit visual knowledge in real time. Precisely how to index this visual knowledge computationally and systematically still poses a challenge to the computing community.
My dissertation research results in novel computational approaches for highthroughput visual knowledge analysis and retrieval from large-scale databases using latest technologies in big data ecosystems. To provide a better understanding of visual reasoning, human gaze patterns are qualitatively measured spatially and temporally to model observers’ cognitive process. These gaze patterns are then indexed in a NoSQL distributed database as a visual knowledge repository, which is accessed using various unique retrieval methods developed through this dissertation work. To provide meaningful retrievals in real time, deep-learning methods for automatic annotation of visual activities and streaming similarity comparisons are developed under a gaze-streaming framework using Apache Spark.
This research has several potential applications that offer a broader impact among the scientific community and in the practical world. First, the proposed framework can be adapted for different domains, such as fine arts, life sciences, etc. with minimal effort to capture human reasoning processes. Second, with its real-time visual knowledge search function, this framework can be used for training novices in the interpretation of domain images, by helping them learn experts’ reasoning processes. Third, by helping researchers to understand human visual reasoning, it may shed light on human semantics modeling. Finally, integrating reasoning process with multimedia data, future retrieval of media could embed human perceptual reasoning for database search beyond traditional content-based media retrievals.
Freeman, Norman A. "Design and analysis of a high-frequency needle-based ultrasound imaging system." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0019/MQ54089.pdf.
Повний текст джерелаZhu, Xinghua, and 朱星华. "Multi-compartment model estimation and analysis in high angular resolution diffusion imaging." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206696.
Повний текст джерелаpublished_or_final_version
Computer Science
Doctoral
Doctor of Philosophy
Salisbury, Victoria Alice. "High resolution imaging and analysis of endothelial tubulogenesis and blood vessel formation." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7322/.
Повний текст джерелаLum, John William. "High-speed imaging and analysis of the solidification of undercooled alloy melts." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/39762.
Повний текст джерелаChen, Gongyin 1968. "Study of high-energy gamma-ray imaging detectors for fast neutron analysis." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/85318.
Повний текст джерелаTulukcuoglu, Güneri Ezgi. "Development of microfluidic device for high content analysis of circulating tumor cells." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066583/document.
Повний текст джерелаMetastasis is the advanced stage of cancer progression and is the cause of 90% of deaths in cancer disease. During metastatic cascade, it is suggested that the successful metastatic initiation depends on the survival of circulating tumor cells (CTCs). CTCs are the cells that shed from the primary or secondary tumor sites into the blood circulation. it is now widely recognized as potential biomarker for companion diagnostics in which high number of CTCs in blood can indicate association with poor survival or high risk of disease progression. Besides, following the number of CTCs during the course of treatment can help to adapt the selected therapy and predict the treatment efficacy. On the other hand molecular characterization can provide patient stratification and identifying the therapeutic targets. However they are extremely rare in the bloodstream, estimated between 1-10 CTC among 6×106 leukocytes, 2×108 platelets and 4×109 erythrocytes per one mL of blood which makes their isolation very challenging. A very attractive way of isolation of CTCs is to integrate microfluidics. Microfluidics offers great advantages such as low volume of reagent consumption and short analysis times with automation as well as isolation and detection analysis can be integrated resulting in highly efficient biomedical devices for diagnostics. As parallel to state of the art, a powerful microfluidic device for circulating tumor cells capture and analysis had already been developed previously in our laboratory. The principle of capture is based on self-assembly of antibody-coated (EpCAM) magnetic beads in which the cells are enriched by EpCAM surface antigen which is found commonly in epithelial origin cancer cells. This system was already validated with cell lines and patients samples. However, the system did not allow isolation/detection of subpopulations of CTCs or performing high content molecular characterization. Therefore, my PhD project aimed at further improving the capabilities of the system on the main two aspects: targeting subpopulations of CTC and studying of protein interactions of CTCs in Ephesia System
Penney, Kimberley. "Anatomy of junior high science textbooks : a content analysis of textual characteristics /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0030/MQ62414.pdf.
Повний текст джерелаLo, Ernest. "Statistical analysis of a high-content screening assay of microtubule polymerization status." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=92232.
Повний текст джерелаFindings relevant to HCS data analysis in general include: (1) Spatial plate biases are significant in HCS data and manifest differently for different cell-level metrics; (2) Individual plates are separate statistical entities; thus cellular data in HCS cannot in general be pooled before proper normalization procedures are applied; (3) Inter-plate variance is significant in HCS data such that inter-plate replicates are a necessity. However HCS data also appears to be amenable for empirical Bayes methods for improving sensitivity to 'hit' compounds; (4) Cell populations are observed to respond heterogeneously to treatment compounds. Initial tests of an alternative cell population summary statistic (the AUC) thought to be suited for the detection of cell subpopulations, did not indicate significant improvements in sensitivity over conventional measures (such as the population median) however.
The correlation texture metric was identified as showing greatly increased sensitivity, when used on the Tyr-tubulin-specific channel. The identification of this cell-level metric provides a preliminary demonstration that high-content assays have the potential to provide superior performance over conventional whole-well HTS assays. An image-processing related issue termed the 'area-intensity confound', was also identified as a possible major source of variability that limited the performance of the alternative cell-level metrics that were developed. A resolution to this issue is proposed.
Many open questions and avenues of further investigation remain, and the current study represents only a preliminary step in the ongoing analysis of the HCS microtubule polymerization status assay, and the development of pertinent statistical inference methods.
La présente étude décrit l'analyse du premier criblage à haut-contenu (HCS) d'un test multi-paramétrique utilisant trois marqueurs fluorescents; ce test permet d'explorer l'état de polymérisation des microtubules.
Ce travail se distingue par deux caractéristiques novatrices:
1) L'extraction d'une nouvelle catégorie de mesures cellulaires qui caractérisent des organites cellulaires de type « fibres » (en utilisant l'algorithme Fiberscore) dans un criblage haut-contenu,
2) Le développement d'un algorithme pour la correction du manque d'uniformité des images permettant l'analyse non biaisée des cellules sombres.
Les résultats inhérents à l'analyse de données de HCS incluent en général les points suivants: (1) Les biais spatiaux liés aux plaques sont significatifs et se manifestent différemment selon les paramètres mesurés; (2) Chaque plaque est une entité statistique distincte; donc les données de HCS ne peuvent pas être compilées sans utilisation préalable de méthodes de normalisation appropriées; (3) La variance entre les plaques est significative; ainsi la présence de réplicats est cruciale. Cependant, les données HCS sont conformes à l'application de la méthode de Bayes empirique en vue d'améliorer la sensibilité aux composés bio-actifs; (4) Les cellules répondent de façon hétérogène au traitement par des petites molécules chimiques. Cependant, contrairement à notre attente, les tests réalisés avec l'approche statistique 'AUC' n'ont pas indiqué une amélioration de puissance statistique.
La mesure texturale de 'corrélation' a été identifiée comme une mesure qui présente une puissance statistique plus importante sur le canal de 'Tyr-tubulin'. L'identification de cette mesure fournit une démonstration préliminaire que les criblages HCS pourraient être plus performants que les criblages à haut débit conventionnels (HTS). Un problème lié au traitement d'images et plus particulièrement à la segmentation des images, que nous avons appellé 'the area-intensity confound', a été identifié comme une source importante de variabilité : ceci a limité la performance des mesures cellulaires alternatives qui ont été développées. Une solution à ce problème est proposée.
Il reste plusieurs questions ouvertes et de nombreuses voies de recherches à explorer. Cette étude n'est qu'une étape préliminaire dans l'analyse du criblage à haut-contenu sur l'état de polymérisation des microtubules, et le développement des méthodes statistiques pertinentes.
Rameseder, Jonathan. "Multivariate methods for the statistical analysis of hyperdimensional high-content screening data." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/92957.
Повний текст джерелаThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references.
In the post-genomic era, greater emphasis has been placed on understanding the function of genes at the systems level. To meet these needs, biologists are creating larger, and increasingly complex datasets. In recent years, high-content screening (HCS) using RNA interference (RNAi) or other perturbation techniques in combination with automated microscopy has emerged as a promising investigative tool to explore intricate biological processes. Image-based HC screens produce massive hyperdimensional data sets. To identify novel components of the DNA damage response (DDR) after ionizing radiation, we recently performed an image-based HC RNAi screen in an osteosarcoma cell line. Robust univariate hit identication methods and manual network analysis identied an isoform of BRD4, a bromodomain and extra-terminal domain family member, as an endogenous inhibitor of DDR signaling. However, despite the plethora of data generated from our and other HC screens, little progress has been made in analyzing HC data using multivariate computational methods that exploit the full richness of hyperdimensional data and identify more than just the most salient knockdown phenotypes to gain a detailed understanding of how gene products cooperate to regulate complex cellular processes. We developed a novel multivariate method using logistic regression models and least absolute shrinkage and selection operator regularization for analyzing hyperdimensional HC data. We applied this method to our HC screen to identify genes that exhibit subtle but consistent phenotypic changes upon knockdown that would have been missed by conventional univariate hit identication approaches. Our method automatically selects the most predictive features at the most predictive time points to facilitate the more ecient design of follow-up experiments and puts the identied hits in a network context using the Prize-Collecting Steiner Tree algorithm. This method offers superior performance over the current gold standard for the analysis of HC RNAi screens. A surprising finding from our analysis is that training sets of genes involved in complex biological phenomena used to train predictive models must be broken down into functionally coherent subsets in order to enhance new gene discovery. Additionally, we found that in the case of RNAi screening, statistical cell-to-cell variation in phenotypic responses in a well of cells targeted by a single shRNA is an important predictor of gene dependent events.
by Jonathan Rameseder.
Ph. D.
Claveau, Sandra. "Fluorescent nanodiamonds as siRNA vectors : in vitro efficacy evaluation and high-content/high-resolution quantifications of their distribution in vivo." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS119/document.
Повний текст джерелаEwing Sarcoma is a rare pediatric cancer, caused in the majority of the cases by the expression of the fusion oncogene EWS-Fli1. Current treatments have not much evolved over the past decades. We are investigating a new therapy based on siRNA specifically targeting the oncogene and inhibiting the tumor growth. During my PhD thesis, I have tested different types of synthetic nanodiamonds (ND) used to vectorize siRNA electrostatically bound at their surface: ND produced by detonation (DND) or by High Pressure-High Temperature synthesis (NDHPTH). Their surfaces have been cationized by various processes: (i) plasma or (ii) thermal hydrogenation, (ii) chemical treatment, or (iv) covalent grafting of a copolymer (COP-NDHPHT).My PhD work included two main axis: (i) in vitro study of ND:siRNA complexes (NDs physico-chemical characterization and oncogene inhibition efficacy by the complexes); (ii) tissue distribution of COP-NDHPHT, injected into mice, using fluorescent NDHPHT containing nitrogen-vacancy defects. To detect them individually in sections of mouse organs carrying a subcutaneous xenograft tumor, we developed an epifluorescence imaging system with large numerical aperture and resolved in time to reject tissue autofluorescence (of a shorter lifetime than NDs). We quantified the number, the aggregation state and the cell localization (thanks to simultaneous histopathological imaging) of these vectors 24 hours after injection. NDs have been clearly detected in different organs, including the tumor, paving the way for tumor progression control with siRNA
O'Neil, Alanna R. "Chemiluminescence and High Speed Imaging of Reacting Film Cooling Layers." University of Dayton / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1324042434.
Повний текст джерелаAboulmagd, Khodier Sarah. "Analysis of Lipids in Kidney Tissue Using High Resolution MALDI Mass Spectrometry Imaging." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19443.
Повний текст джерелаMass spectrometry imaging is indispensable for studying the spatial distribution of molecules within a diverse range of biological samples. Since its introduction, MALDI has become a dominant imaging method, which proved useful to sort out the complexity of lipid structures in biological tissues. The role of cisplatin in the treatment of human malignancies is well-established. However, nephrotoxicity is a limiting side effect that involves an acute injury of the proximal tubule and alterations in the renal lipid profile. This evolved the motivation to study the spatial distribution of lipids in the kidney tissue of cisplatin-treated rats to shed light on the lipid signaling pathways involved. A method for mapping of lipid distributions in kidney sections using MALDI-LTQ-Orbitrap was developed, utilizing the high performance of orbitrap detection. The distribution of kidney lipids in cisplatin-treated samples revealed clear differences with respect to control group, which could be correlated to the proximal tubule injury. The findings highlight the usefulness of MALDI MSI as complementary tool for clinical diagnostics. Furthermore, assessment of the ion images of lipids in cisplatin-treated kidney mostly considered qualitative aspects. Relative quantitative comparisons were limited by the variable influence of experimental and instrumental conditions. Hence, the necessity developed to establish a normalization method allowing comparison of lipid intensity in MALDI imaging measurements of different samples. The method employed an inkjet printer to apply a mixture of the MALDI matrix and dual lipid-metal internal standards. Using ICP-MS, the metal internal standard allowed to confirm the consistency of the matrix and internal standards application. Applying the method to normalize ion intensities of kidney lipids demonstrated excellent image correction and successfully enabled relative quantitative comparison of lipid images in control and cisplatin-treated samples.
Nketia, Thomas. "Quantitative analysis of cell function and death in label-free high content screening." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:f58ce337-5422-4a29-bc35-5bccbccf9ddc.
Повний текст джерелаSardiello, Ezequiel Josue Miron. "Comprehensive mapping of the 3D epigenome by high-content super-resolution image analysis." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:d6c0f208-1acd-459b-94cf-a4e44de9bc43.
Повний текст джерелаGomez, Gonzalez Carlos Alberto, Olivier Wertz, Olivier Absil, Valentin Christiaens, Denis Defrère, Dimitri Mawet, Julien Milli, et al. "VIP: Vortex Image Processing Package for High-contrast Direct Imaging." IOP PUBLISHING LTD, 2017. http://hdl.handle.net/10150/624676.
Повний текст джерелаChen, Shichao. "High-sensitivity Full-field Quantitative Phase Imaging Based on Wavelength Shifting Interferometry." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/102502.
Повний текст джерелаDoctor of Philosophy
Wheeler-Kingshott, Claudia A. "High speed MRI : analysis of new approaches to fast imaging using Burst-based sequences." Thesis, University of Surrey, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268089.
Повний текст джерелаScharfman, Barry Ethan. "Analysis of multiphase fluid flows via high speed and synthetic aperture three dimensional imaging." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/78188.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references.
Spray flows are a difficult problem within the realm of fluid mechanics because of the complicated interfacial physics involved. Complete models of sprays having even the simplest geometries continue to elude researchers and practitioners. From an experimental viewpoint, measurement of dynamic spray characteristics is made difficult by the optically dense nature of many sprays. Flow features like ligaments and droplets break off the bulk liquid volume during the atomization process and often occlude each other in images of sprays. In this thesis, two important types of sprays are analyzed. The first is a round liquid jet in a cross flow of air, which applies, for instance, to fuel injection in jet engines and the aerial spraying of crops. This flow is studied using traditional high-speed imaging in what is known as the bag breakup regime, in which partial bubbles that look like bags are formed along the downstream side of the liquid jet due to the aerodynamic drag exerted on it by the cross flow. Here, a new instability is discovered experimentally involving the presence of multiple bags at the same streamwise position along the jet. The dynamics of bag expansion and upstream column wavelengths are also investigated experimentally and theoretically, with experimental data having found to generally follow the scaling arguments predicted by the theory. The second flow that is studied is the atomization of an unsteady turbulent sheet of water in air, a situation encountered in the formation and breakup of ship bow waves. To better understand these complicated flows, the emerging light field imaging (LFI) and synthetic aperture (SA) refocusing techniques are combined to achieve three-dimensional (3D) reconstruction of the unsteady spray flow fields. A multi-camera array is used to capture the light field and raw images are reparameterized to digitally refocus the flow field post-capture into a volumetric image. These methods allow the camera array to effectively "see through" partial occlusions in the scene. It is demonstrated here that flow features, such as individual droplets and ligaments, can be located in 3D by refocusing throughout the volume and extracting features on each plane.
by Barry Ethan Scharfman.
S.M.
Walker, Lucy. "High interest, low content : a content analysis of 2004 campaign information found in five leading consumer magazines aimed at young adults /." abstract and full text PDF (free order & download UNR users only), 2005. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1433112.
Повний текст джерела"August, 2005." Includes bibliographical references (leaves 80-88). Library also has microfilm. Ann Arbor, Mich. : ProQuest Information and Learning Company, [2005]. 1 microfilm reel ; 35 mm. Online version available on the World Wide Web.
Collinet, Claudio. "System Survey of Endocytosis by Functional Genomics and Quantitative Multi-Parametric Image Analysis." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-38278.
Повний текст джерелаKarphammar, Anette, and Maria Behrns. "Advertising in high- and low context cultures : A comparative content analysis between Sweden and Brazil." Thesis, Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-37075.
Повний текст джерелаSchweller, Ryan. "Development of Dynamic DNA Probes for High-Content in situ Proteomic Analyses." Thesis, 2012. http://hdl.handle.net/1911/64649.
Повний текст джерелаHo, Derek. "CMOS Contact Imagers for Spectrally-multiplexed Fluorescence DNA Biosensing." Thesis, 2013. http://hdl.handle.net/1807/35849.
Повний текст джерелаYeh, Chih-wen, and 葉志文. "The Content Analysis of Senior High School English Textbooks." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/25731228925478953492.
Повний текст джерела國立高雄師範大學
教育學系
91
The goal of this research is to analyze the content of English textbooks to know the vocabulary frequency, the difficulty of the reading, themes and paragraph précis. The researcher also discussed about the difference between textbooks. In this research, content analysis is adopted. The first thing is to research and refer to domestic and foreign documents and literature related to develop the measurements to analyze the content of senior high school English textbooks. Three versions of English have been analyzed: Far East version, Lung-teng version and NICT (National Institute for Compilation and Translation) version. The measurements applied in this study included “frequency band” in Collins Cobuild English Dictionary (1995), “Lix formula” by Bjornsson(1968) and “themes and paragraph précis form”. The results are as follows: 1.The vocabulary frequency is affected by theme and phraseology. Phraseology is the particular way in which words and phrases are arranged when saying or writing something. The vocabulary frequency between three versions is similar. The number of vocabulary in NICT version is more than the others. Far East version is more than Lung-teng version. 2.The difficulty of reading is affected by phraseology. Three versions are all from simple sentences to complicated sentences. Reading in NICT version is the most difficult. Reading in Lung-teng version is more difficult than reading in Far East version. In all versions, the readings about dialogue and stories are always the longest. The readings are always the shortest while the readings about the poems. 3.The form of themes in Far East version and Lung-teng version are different. There is one theme for one lesson in Far East version. And there is one theme for two lessons in Lung-teng version. The paragraph précis in three versions are different and hard to conclude. According to the conclusions, following are the suggestions: 1.Some technicalities should be designed carefully, or they could lower students’ motivation to learn English. 2.The difficulty between books should be from simple sentences to complicated sentences. The readings in lower grades should have more simple sentences than in older grades. The difference in books should be large to fit the need of senior high students. 3.The themes in English textbooks should be vivid and relevant to life in order to fit students’ learning process. And the paragraph précis should be connected with the themes to give students a complete conception about the lesson. 4.English teachers can choose the proper articles by Lix formula in their teaching. And Lix formula could also be the indicator of teaching designs and teaching methods.
Chang, Shih-Hsin, and 張世欣. "Theoretical Analysis and Applications of the High Dynamic Range Imaging." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/81518880223770095608.
Повний текст джерела國立雲林科技大學
工程科技研究所博士班
99
Recently, the study of high dynamic range imaging technology which is founded on the camera response function suggested that an image detector could replace many traditional photo-diode sensors. Until now, measurement of an automotive headlamp light distribution pattern is a very tedious and time-consuming processes by using photometers. Also in photoelasticity, many researches tried improve traditional measurement method that the cumbersome process of data collection troubled people. There are many studies on photoelasticity have been conducted, and many equations for photoelastic analysis based on digital images were proposed. While these equations were all presented by the light intensity emitted from the analyzer, pixel values of the digital image were actually used in the real calculations and this is not for real situations. In this thesis, high dynamic range imaging technology and camera response function were applied to these two measurements by using a digital camera. Traditional measurement of the headlamp distribution has been based on a point by point approach using goniophotometer. In this thesis, an imaging photometer is developed by combining a regular digital camera and high dynamic range imaging technique to achieve faster and more complete measurement of the entire distribution. The experimental results indicate that errors of the measurements are within 10% of the true values, which is better than the 20% requirements of the industry. Furthermore, the proposed approach can provide a very wide dynamic range only limited by the shutter speed of the camera. We believe this new method would provide the headlamp industries with a much more friendly environment for evaluating their designs of new products in a faster and very economical way. In the second part of this thesis, a proposal of using relative light intensity obtained by the camera response function to replace the pixel value for photoelastic analysis was investigated. Generation of isochromatic images based on relative light intensity and pixel value were compared to evaluate the effectiveness of the new approach. The results showed that when relative light intensity was used, the quality of isochromatic image can be greatly improved both visually and quantitatively. The technique proposed in this paper can also be used to improve the performance for the other types of photoelastic analysis using digital images.
Yao, Xiaohui. "Mining high-level brain imaging genetic associations." Diss., 2018. http://hdl.handle.net/1805/15831.
Повний текст джерелаImaging genetics is an emerging research field in neurodegenerative diseases. It studies the influence of genetic variants on brain structure and function. Genome-wide association studies (GWAS) of brain imaging has identified a few independent risk loci for individual imaging quantitative trait (iQT), which however display only modest effect size and explain limited heritability. This thesis focuses on mining high-level imaging genetic associations and their applications on neurodegenerative diseases. This thesis first presents a novel network-based GWAS framework for identifying functional modules, by employing a two-step strategy in a top-down manner. It first integrates tissue-specific network with GWAS of corresponding phenotype in regression models in addition to classification, to re-prioritize genome-wide associations. Then it detects densely connected and disease-relevant modules based on interactions among top reprioritizations. The discovered modules hold both phenotypical specificity and densely interaction. We applied it to an amygdala imaging genetics analysis in the study of Alzheimer's disease (AD). The proposed framework effectively detects densely interacted modules; and the reprioritizations achieve highest concordance with AD genes. We then present an extension of the above framework, named GWAS top-neighbor-based (tnGWAS); and compare it with previous approaches. This tnGWAS extracts densely connected modules from top GWAS findings, based on the hypothesis that relevant modules consist of top GWAS findings and their close neighbors. It is applied to a hippocampus imaging genetics analysis in AD research, and yields the densest interactions among top candidate genes. Experimental results demonstrate that precise context does help explore collective effects of genes with functional interactions specific to the studied phenotype. In the second part, a novel imaging genetic enrichment analysis (IGEA) paradigm is proposed for discovering complex associations among genetic modules and brain circuits. In addition to genetic modules, brain regions of interest also grouped to play role. We expand the scope of one-dimensional enrichment analysis into imaging genetics. This framework jointly considers meaningful gene sets (GS) and brain circuits (BC), and examines whether given GS-BC module is enriched in gene-iQT findings. We conduct the proof-of-concept study and demonstrate its performance by applying to a brain-wide imaging genetics study of AD.
Li, Yu-Shen, and 李育慎. "Accessing the aquiferous content using high frequency eletrical impedance analysis." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/20925104657276069173.
Повний текст джерела中原大學
生物醫學工程研究所
98
Under human skin, it is a complex tissue which consists of muscles, fat, and many more with different physiological states. However, the muscle and fat under the skin do not change in a short period of time except the aquiferous content inside and under the skin. Therefore, we will know the metabolism state of human being by observing the change of aquiferous content in superficial tissues under the skin in a short period of time. The FPGA programmable system chip was specifically designed to stimulate the body using constant current high frequency signal. In this way, the system has the ability to monitor and record biological impedance signals of body. The prototype system was also including functions of data display with LCD, data storage with FLASH memory, data communication with USB. An off-line PC window program was also provided for reviewing the recorded impedance and analyzed impedance with high frequency. The system was used to access the psychophysic effect of aquiferous content monitoring over four circumstances. They were situations of monitoring the before drinking water, after drinking water, before meal, and after meal. It was to examine the impact of aquiferous content on different physiological states. During different frequency stimulation, the impedance of skin changed, so we used high-frequency scan to find the range of frequency. And, we also observed the changes of aquiferous content of shallow tissue under human skin in patients with diabetes. The relationship between changes in the aquiferous content of the skin and in blood glucose was to be discussed.
Meng, Yi-Ting, and 孟依亭. "Design and Analysis of High Moisture Content Paddy Drying Simulator." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/18460924848117562626.
Повний текст джерела國立臺灣大學
生物產業機電工程學研究所
102
High moisture content paddy emergency harvested in rainy season is a serious problem in Taiwan. It might prolong drying time to congest operating schedule of paddy drying centers and also increase drying costs. Currently, commercial circulating dryers are mature commodities. However, various designs and operations might lead to different drying efficiency and energy costs. The purpose of this study is to device a drying simulator based on circulating drying principles to investigate dryer designing and operation for high moisture content paddy. Pre-drying operation tests were conducted in the simulator to dry high moisture content paddy to its critical moisture content. Various parameters were chosen and model of Box Behnken Design (BBD) was adopted under three levels of factors. Levels of paddy layer thickness are 6cm, 9cm, and 12cm; levels of specific air flow rate are 0.3CMM/kg, 0.5CMM/kg, and 0.7CMM/kg; levels of drying time are 10min, 20min, and 30min. It is difficult to measure internal changes in the paddy layer during drying, so heat and mass transfer model was built and simulated by FEM software (Comsol Multiphysics 4.3a) to predict internal changes in the paddy layer. Experimental results showed 98% total energy consumed in drying process being used in heating and desorption of water in grain and the rest being used in air flowing to carry mass and energy. The most efficient way in pre-drying was to dry wet grain to the critical moisture content in one pass. Various passes drying might consume more energy in heating up grain to drying temperature in each pass; besides, the benefit of tempering was insignificant in pre-drying stage. In the range of operations, combinations of specific air flow rate and drying time in 0.3CMM/kg-30min, 0.5CMM/kg-20min, and 0.7CMM/kg-20min with high energy efficiency and high air flow rate, also resulted in high drying rate. Because specific air flow rate was used in experimental design the influence of the paddy layer thickness was not significant. However, simulation results showed that thick layer drying might lead to high moisture content variation along the air flow direction. This phenomenon may affect subsequent drying operation, so it is suggested for further research.
XU, ZHE-WEI, and 許哲維. "Content Analysis and Research on Geography Textbooksof Junior High School." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/5zfd4v.
Повний текст джерела國立臺中教育大學
區域與社會發展學系碩士班
100
This research examines the distribution of geographic concepts in geography textbooks of junior high school at the fourth learning stage of Taiwan’s Grade 1-9 Curriculum and compiles the presentation of the competence indicator of each grade intended to be achieved by the nine subjects in these textbooks. The researcher reviews both foreign and domestic literatures and constructs a category table of different geographic concepts found in the junior high school geography textbooks. The content analysis method is applied to analyze the contents of the three editions of Taiwan’s junior high school geography textbooks and supplementary materials. The competence indicator of each grade which is intended to be achieved by the three editions of the geography textbooks is also compiled. The major points under discussion are: (1) How are geographic concepts distributed in the different editions of junior high school geography textbooks? (2) Is there any difference in the distribution of geographic concepts among different editions of junior high school geography textbooks? (3) What is the competence indicator of each grade intended by the different editions of junior high school geography textbooks? (4) Is there any difference in the competence indicator of each grade among the different editions of junior high school geography textbooks? The research findings are as follows: (1) In respect of the sub-fields, the distributions of geographic concepts in the three editions are the same. Geographical concepts appear most frequently in the sub-field of “Human Geography”, and appear least frequently in the sub-field of “Geographical Skills.” (2) In respect of each individual sub-field, although geographic concepts appear in the four sub-fields with various degrees, the chi-square test concludes that there is no significant difference in the three editions regarding the distribution of geographic concepts in the same sub-field. (3) In respect of the sub-fields in the three editions of junior high school geography textbooks, there is only difference in the distribution of the main categories in the sub-field of Physical Geography. There is no significant difference in the other three sub-fields among the three editions. (4) In respect of the main categories in the three editions of the geography textbooks of junior high school, there is only difference in the distribution of the sub-categories in the two main categories of “Economy” and “Culture and Humanity.” There is no significant difference in the other main categories among the three editions. (5) The distribution of the competence indicator of each grade which is intended to be achieved in the three editions is highly uneven, with 90% concentrated in the subject of “People and Space.” (6) Among the three editions of geography textbooks, the competence indicator of each grade clearly appears more frequently in Nan-Yi and Han-Lin editions than Kang Hsuan edition in all learning stages with the only exception of the fourth learning stage (junior high school). Key words: Junior high school geography textbook, Geographic concept, the competence indicator of each grade, Content analysis
CHEN, YI-CHUN, and 陳怡君. "The Content Analysis of Science Textbooks for Junior High School." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/vem33r.
Повний текст джерела明道大學
課程與教學研究所
106
The Content Analysis of Science Textbooks for Junior High School Abstract The purpose of the study was to analyze the differences between the illustrations of physical and chemical contents in Science textbooks for junior high school. The study was to investigate the space that illustrations use and ways that illustrations presenting and to discuss the functions that illustrations have in textbooks. It is expected to find out the differences between the versions of Science textbooks .The content analysis method was adopted in this study. Take the three versions of Kangxuan, Hanlin and Nanyi on book 6 of physical and chemical contents in Science textbooks for junior high school was used as a research sample. The study found that:(1)The K version accounted for about 29.94% of the textbooks, and the H version accounted for about 27.96% of the textbooks,and the N version accounted for about 24.55% of the textbooks. (2)The illustrations of the three versions are all presented with a higher percentage of the graphic illustrations. The K version accounted for about 64.30% of the total inlay area, and the H version accounted for about 67.38% of the total inlay area,and the N version accounted for about 66.58% of the total inlay area.(3)With represent to the functional illustrations in the three versions, organizational flow illustrations all rate the highest and decorative illustrations all rate the lowest in every versions. The organizational flow illustrations of the K version accounted for about 32.40% of the total inlay area, and the organizational flow illustrations of the H version accounted for about 25.39% of the total inlay area,and the organizational flow illustrations of the N version accounted for about 38.02% of the total inlay area. The decorative illustrations of the K version accounted for about 0.68% of the total inlay area, and the decorative illustrations of the H version accounted for about 0.48% of the total inlay area,and the decorative illustrations of the N version accounted for about 0.33% of the total inlay area.(4)The three versions all focus on the organizational flow illustrations and simple performance illustrations.However, the total inlay area of the third and fourth places in the K version are structured illustrations and situation-directed illustrations.The total inlay area of the third and fourth places in the H version are situation-directed illustrations and symbolic illustrations. The total inlay area of the third and fourth places in the N version are structured illustrations and statistics illustrations. According to the research results, provide teachers with reference to textbooks. Keywords:junior high school, science, textbook, content analysis, illustration
Patel, Rita R. "High speed digital imaging and kymographic analysis of vocal fold vibrations." 2006. http://www.library.wisc.edu/databases/connect/dissertations.html.
Повний текст джерелаHou, Pei-Chun, and 侯佩君. "A Content Analysis on Biodiversity in Junior-High-School Mandarin Textbooks." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/7jgsyq.
Повний текст джерела銘傳大學
教育研究所碩士班
93
Biodiversity is one of the core topics to environmental education. It is also an important topic in the 9-Year-Continuous Curriculum of Taiwan which emphasizes environmental education should be inclusive into each learning field. The purpose of the study is to explore the distribution and presentation of biodiversity in junior-high-school mandarin textbooks. The researcher gives some suggestions for education and the future study, and hopes the result of the study would facilitate the development and revision of mandarin textbooks. The analytic category of biodiversity which is based on “Convention on Biological Diversity” and “Taiwan National Biodiversity Report” includes four aspects-the levels of biodiversity, the values of biodiversity, the disappearance of biodiversity, and the conservation of biodiversity. The study has the following findings: 1.The central-theme and sub-theme in junior-high-school mandarin textbooks are mainly of the values of biodiversity. 2.In the values of biodiversity, esthetical value is the major topics discussed in mandarin textbooks. 3.In the levels of biodiversity, species diversity is the major topics discussed in mandarin textbooks. 4.In the disappearance of biodiversity, over-consumption natural resource is the major reason discussed in mandarin textbooks. 5.In the conservation of biodiversity, revive conservation is the only topic appeared in mandarin textbooks. 6.Among the five goals of environmental education, mandarin teaching in junior high school emphasizes the importance of environmental ethical values.