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Статті в журналах з теми "HIFU transducer":
1
Shin, Eui-Ji, Byungwoo Kang, and Jin Chang. "Real-Time HIFU Treatment Monitoring Using Pulse Inversion Ultrasonic Imaging." Applied Sciences 8, no. 11 (November 11, 2018): 2219. http://dx.doi.org/10.3390/app8112219.
Анотація:
Real-time monitoring of high-intensity focused ultrasound (HIFU) surgery is essential for safe and accurate treatment. However, ultrasound imaging is difficult to use for treatment monitoring during HIFU surgery because of the high intensity of the HIFU echoes that are received by an imaging transducer. Here, we propose a real-time HIFU treatment monitoring method based on pulse inversion of imaging ultrasound; an imaging transducer fires ultrasound twice in 0° and 180° phases for one scanline while HIFUs of the same phase are transmitted in synchronization with the ultrasound transmission for imaging. By doing so, HIFU interferences can be eliminated after subtracting the two sets of the signals received by the imaging transducer. This function was implemented in a commercial research ultrasound scanner, and its performance was evaluated using the excised bovine liver. The experimental results demonstrated that the proposed method allowed ultrasound images to clearly show the echogenicity change induced by HIFU in the excised bovine liver. Additionally, it was confirmed that the moving velocity of the organs in the abdomen due to respiration does not affect the performance of the proposed method. Based on the experimental results, we believe that the proposed method can be used for real-time HIFU surgery monitoring that is a pivotal function for maximized treatment efficacy.
2
Liu, Li, and Jian Sun. "A Study of High Intensity Focusing Ultrasonic Transducer." Applied Mechanics and Materials 201-202 (October 2012): 20–23. http://dx.doi.org/10.4028/www.scientific.net/amm.201-202.20.
Анотація:
High intensity focused ultrasound (HIFU) is the fourth brand-new and efficient means to cure tumour acknowledged by the medical field. Study of ultrasonic transducer is a core part of HIFU technique, In order to ensure reliability and safety of treatment, it is a key for HIFU technique to realize accurate focusing of ultrasonic energy. In the thesis, ultrasonic focusing method, studies of current situations of cell and multiplex array focusing transducers and their existing problems are illustrated based on analyzing challenges faced by HIFU treatment at present. This study suggested that phased array was theoretically easy for realizing accurate control of computer， however, unbeneficial factors and engineering technical problems still exist; How to promote intensity of the focal spot of cell array focusing transducer, enlarge scope of the focal area and improve control way of the focal spot was a bottleneck problem for publicizing and applying cell array focusing transducer and one of urgent research topics for ensuring curative effect of HIFU and avoiding heat damages.
3
Shan, Feng, Xiasheng Guo, Juan Tu, Jianchun Cheng, and Dong Zhang. "Multi-relaxation-time lattice Boltzmann modeling of the acoustic field generated by focused transducer." International Journal of Modern Physics C 28, no. 03 (March 2017): 1750038. http://dx.doi.org/10.1142/s0129183117500383.
Анотація:
The high-intensity focused ultrasound (HIFU) has become an attractive therapeutic tool for the noninvasive tumor treatment. The ultrasonic transducer is the key component in HIFU treatment to generate the HIFU energy. The dimension of focal region generated by the transducer is closely relevant to the safety of HIFU treatment. Therefore, it is essential to numerically investigate the focal region of the transducer. Although the conventional acoustic wave equations have been used successfully to describe the acoustic field, there still exist some inherent drawbacks. In this work, we presented an axisymmetric isothermal multi-relaxation-time lattice Boltzmann method (MRT-LBM) model with the Bouzidi–Firdaouss–Lallemand (BFL) boundary condition in cylindrical coordinate system. With this model, some preliminary simulations were firstly conducted to determine a reasonable value of the relaxation parameter. Then, the validity of the model was examined by comparing the results obtained with the LBM results with the Khokhlov–Zabolotskaya–Kuznetsov (KZK) equation and the Spheroidal beam equation (SBE) for the focused transducers with different aperture angles, respectively. In addition, the influences of the aperture angle on the focal region were investigated. The proposed model in this work will provide significant references for the parameter optimization of the focused transducer for applications in the HIFU treatment or other fields, and provide new insights into the conventional acoustic numerical simulations.
4
Bui, Ngoc Thang, Thi My Tien Nguyen, Gebremedhin Yonatan Ataklti, Quoc Cuong Bui, Tran Thanh Nam Dinh, Duc Tri Phan, Sumin Park, Jaeyeop Choi, Thi Thu Ha Vu, and Junghwan Oh. "Design of a High-Power Multilevel Sinusoidal Signal and High-Frequency Excitation Module Based on FPGA for HIFU Systems." Electronics 10, no. 11 (May 29, 2021): 1299. http://dx.doi.org/10.3390/electronics10111299.
Анотація:
High-intensity focused ultrasound (HIFU) is a noninvasive therapy that uses focused ultrasound to treat a part of the tissue; high temperatures can damage tissues by heat. HIFU has many applications in the field of surgery and aesthetics and is used increasingly in everyday life. In this article, we discuss the mainboard design that controls the HIFU system with the ability to create a multistep sine wave compatible with many different applications. The signal used to trigger the transducer is a sinusoidal signal with a frequency adjustable from 0.1 to 3 MHz. In addition, the power supplied to the HIFU transducer is also controlled easily by the configuration parameters installed in the control circuit board. The proposed control and design method generates a voltage signal that doubles the supply voltage, thereby reducing the current on the MOSFET. The hardware design is optimized for a surface-mounted device-type MOSFET without the need for an external heat sink. In tests, we conducted a harmonious combination of two output signals to activate the same HIFU probe. The results showed that the energy transferred to the HIFU transducer increased by 1.5 times compared to a single channel. This means that the HIFU treatment time is reduced when using this method, with absolutely no changes in the system structure.
5
Cato, Sharon, Florent Aptel, Philippe Denis, Gail ter Haar, Shlomo Melamed, Eric Sellem, Tarek Shaarawy, and David Wright. "Ultrasound Circular Cyclo-Coagulation – Innovation in Glaucoma with High Intensity Focused Ultrasound." European Ophthalmic Review 05, no. 02 (2011): 109. http://dx.doi.org/10.17925/eor.2011.05.02.109.
Анотація:
Existing treatment modalities for glaucoma, including pharmacological therapy, lasers, surgery and shunts, are all associated with shortcomings. Ultrasonic coagulation of the ciliary body with pinpoint precision using high intensity focused ultrasound (HIFU) enables significant reduction of aqueous inflow and intraocular pressure (IOP). Energy is focused through non-optically transparent media with controlled energy absorption, reducing effects on adjacent tissues. Energy deposition and tissue heating at the focus site do not depend on tissue pigmentation, thus improving predictability. Currently, high-frequency miniaturised transducers create small focal zones for improved treatment area targeting, and ultrasound focusing provides enhanced control. The high operating frequency allows a sharp transition between the focal zone and the untreated area, reducing risks of heating adjacent healthy tissue. Such transducers are used extensively in malignant tumour treatments. Novel Ultrasound Circular Cyclo-Coagulation (UC3) with a miniaturised annular transducer uses HIFU technology. The circular geometry of the device allows precise, constant and reproducible positioning. Results from animal studies and from a clinical pilot study of patients with refractory glaucoma indicate that ultrasonic coagulation of the ciliary body using HIFU delivered by a circular miniaturised transducer is an effective and well-tolerated method of reducing IOP. The single-step procedure is short, easy to perform and accurate. Glaucoma impacts patients’ quality of life, including unpleasant treatment side effects and social and physical aspects. Gold-standard trabeculectomy shortcomings highlight the need for precise, focused surgical modalities. HIFU is a non-invasive, cost-effective innovation that, should the multicentre clinical trial demonstrate similar results to the preclinical and pilot studies, will be a useful addition to current glaucoma management techniques.
6
Seo, Hyunkwan, Sung Kwan Hwang, Hee-Won Kim, and Kyu Chan Lee. "Motion Accuracy of Pneumatic Stepper Motor-Driven Robotic System Developed for MRI-Guided High-Intensity Focused Ultrasound Treatment of Prostate Disease." Applied Bionics and Biomechanics 2024 (May 10, 2024): 1–13. http://dx.doi.org/10.1155/2024/5556537.
Анотація:
The latest advancement in high-intensity focused ultrasound (HIFU) treatment technology integrates magnetic resonance imaging (MRI) guidance for precise treatment of prostate disease. As conventional electromagnetic motors are not applicable for utilization within MRI scanners, we have developed a prototype robotic system driven by pneumatic stepper motors to control the movement of the HIFU transducer within an intrarectal probe during MRI-guided HIFU treatment procedures. These pneumatic stepper motors were constructed entirely from MRI-compatible plastic materials. Assessment of the robotic system’s MRI compatibility was conducted utilizing a 3.0T MRI scanner, revealing no discernible MRI image distortion with a minor decrease in the signal-to-noise ratio (2.8%) during the motor operation. The robotic system enabled the transducer to move inside the probe with two degrees of freedom, allowing both linear and rotational motion. The positional accuracy of the transducer movement was assessed, yielding ±0.20 and ±0.22 mm accuracies in the forward and backward linear movements, respectively, and ±0.79° and ±0.74° accuracies in the clockwise and counterclockwise rotational motions, respectively. Emulation of authentic HIFU procedures involved creating a two-dimensional array of thermal lesions in a tissue-mimicking phantom, achieving positional accuracy within ±1 mm for the generated HIFU focal spots. The prototype robotic system incorporating pneumatic stepper motors fabricated entirely from MRI-compatible plastic materials has demonstrated the requisite positional accuracy necessary for effective HIFU treatment of prostate disease, indicating substantial promise for future clinical application.
7
Lim, Hae Gyun, Hyunhee Kim, Kyungmin Kim, Jeongwoo Park, Yeonggeun Kim, Jinhee Yoo, Dasom Heo, Jinhwan Baik, Sung-Min Park, and Hyung Ham Kim. "Thermal Ablation and High-Resolution Imaging Using a Back-to-Back (BTB) Dual-Mode Ultrasonic Transducer: In Vivo Results." Sensors 21, no. 5 (February 24, 2021): 1580. http://dx.doi.org/10.3390/s21051580.
Анотація:
We present a back-to-back (BTB) structured, dual-mode ultrasonic device that incorporates a single-element 5.3 MHz transducer for high-intensity focused ultrasound (HIFU) treatment and a single-element 20.0 MHz transducer for high-resolution ultrasound imaging. Ultrasound image-guided surgical systems have been developed for lesion monitoring to ensure that ultrasonic treatment is correctly administered at the right locations. In this study, we developed a dual-element transducer composed of two elements that share the same housing but work independently with a BTB structure, enabling a mode change between therapy and imaging via 180-degree mechanical rotation. The optic fibers were embedded in the HIFU focal region of ex vivo chicken breasts and the temperature change was measured. Images were obtained in vivo mice before and after treatment and compared to identify the treated region. We successfully acquired B-mode and C-scan images that display the hyperechoic region indicating coagulation necrosis in the HIFU-treated volume up to a depth of 10 mm. The compact BTB dual-mode ultrasonic transducer may be used for subcutaneous thermal ablation and monitoring, minimally invasive surgery, and other clinical applications, all with ultrasound only.
8
Qian, Jun, Wei Xie, Xiao-Wei Zhou, Jian-Wen Tan, Zhi-Biao Wang, Yong-Hong Du, and Yan-Hao Li. "Real-time monitoring of high intensity focused ultrasound focal damage based on transducer driving signal." Acta Physica Sinica 71, no. 3 (2022): 037201. http://dx.doi.org/10.7498/aps.71.20211443.
Анотація:
Real-time monitoring of high intensity focused ultrasound (HIFU) focal region is a key problem in clinical treatment of focused ultrasound. At present, the change of strong echo in B-ultrasound image is often used in clinical practice to monitor tissue damage in the focal area. However, the strong echo in B-ultrasound image is mostly related to cavitation and boiling bubbles in the focal area, which cannot monitor the treatment status accurately or in real time. In the HIFU treatment, the focal area tissue will be accompanied by changes in temperature, cavitation, boiling, and tissue characteristics. The acoustic load on the surface of the transducer is also constantly changing. To solve this problem, a real-time detection platform of transducer voltage and current is built in this work, which can sense the change of focal area tissue state by measuring the electrical parameters of the transducer. The experimental results show that the stability of the phase difference of the transducer driving signal will be different (the fluctuation amplitude will be different) when different media are placed on the surface of the transducer to change the acoustic load on the surface of the transducer. The fluctuation amplitude of the phase difference of the driving signal will be larger than that in the water when the iron plate is placed in the focal plane. However, the phase fluctuation amplitude will be much smaller than that in the water where the beef liver is placed. This shows that different acoustic loads can cause the electrical parameters of the transducer to change. The isolated bovine liver tissue is used as the HIFU irradiation object, and the results of the phase difference change are compared with the results of the isolated bovine liver tissue damage. The experimental results show that the phase of the transducer voltage and current will change from relatively stable to large fluctuations during the HIFU irradiation. At this time, obvious damage can be seen in the focal region when the irradiation is stopped, and the grayscale of B-ultrasound image has no significant change. In addition, when the cavitation occurs in the focal region, the fluctuation amplitude and range will turn larger. The damage area of the lower focal area under the monitoring method is smaller than that under B-ultrasonic monitoring, and the over input of radiation dose can be avoided. This method can provide a new research scheme and means for HIFU focal area tissue damage monitoring.
9
An, Chih Yu, Jia Hao Syu, Ching Shiow Tseng, and Chih-Ju Chang. "An Ultrasound Imaging-Guided Robotic HIFU Ablation Experimental System and Accuracy Evaluations." Applied Bionics and Biomechanics 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/5868695.
Анотація:
In recent years, noninvasive thermal treatment by using high-intensity focused ultrasound (HIFU) has high potential in tumor treatment. The goal of this research is to develop an ultrasound imaging-guided robotic HIFU ablation system for tumor treatment. The system integrates the technologies of ultrasound image-assisted guidance, robotic positioning control, and HIFU treatment planning. With the assistance of ultrasound image guidance technology, the tumor size and location can be determined from ultrasound images as well as the robotic arm can be controlled to position the HIFU transducer to focus on the target tumor. After the development of the system, several experiments were conducted to measure the positioning accuracy of this system. The results show that the average positioning error is 1.01 mm with a standard deviation 0.34, and HIFU ablation accuracy is 1.32 mm with a standard deviation 0.58, which means this system is confirmed with its possibility and accuracy.
10
Kaczkowski, Peter, and Juvenal Ormachea. "The verasonics platform for ultrasound-guided focused ultrasound preclinical studies." Journal of the Acoustical Society of America 153, no. 3_supplement (March 1, 2023): A101. http://dx.doi.org/10.1121/10.0018303.
Анотація:
Verasonics, in partnership with Sonic Concepts (Bothell, WA, USA), has developed a turnkey platform for Ultrasound-Guided Focused Ultrasound (USgFUS) therapy with performance over a wide range of acoustic regimes. Built around the Verasonics Vantage HIFU ultrasound research system, it uses a 150 mm diameter, f1 HIFU transducer with 64 (0.5 MHz) or 128 (1.1 and 2 MHz) elements arranged in a spiral pattern that produce a highly focused field with low sidelobes over a 3D steering volume. Guidance and monitoring are provided by a coaxially mounted 128-element broadband phased array imaging transducer that can be rotated about the HIFU axis. Coupling to the subject is achieved by means of a membrane sealed water-filled cone through which degassed and temperature regulated water is circulated. The USgFUS applicator is mounted on an articulated arm that can be mechanically locked with a button actuated servo mechanism. Graphical software enables a conventional therapeutic workflow including imaging with any of several B-Mode and Doppler modalities, positioning of the applicator, focal zone exposure planning, therapy delivery, interleaved ultrasound monitoring using any supplied imaging mode or with Thermal Strain Imaging (TSI), and post-therapy imaging. This talk will describe the platform and provide examples of its capabilities using experiments in scattering phantoms and ex vivo tissues.
Дисертації з теми "HIFU transducer":
1
Gelat, P. N. "Focusing the field of a HIFU array transducer through human ribs." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1428445/.
Анотація:
High intensity focused ultrasound (HIFU) enables highly localised, non-invasive tissue ablation, and its efficacy in the treatment of a range of cancers, including those of the kidney, prostate and breast has been demonstrated. HIFU offers the ability to treat deep-seated tumours locally, and potentially bears fewer side effects than more established treatment modalities such as resection, chemotherapy and ionising radiation. There remain, however, a number of significant challenges which currently hinder its widespread clinical application. One of these challenges is the need to transmit sufficient energy through the ribcage to ablate tissue at the required foci whilst minimising the formation of side lobes and sparing healthy tissue. Ribs both absorb and reflect ultrasound strongly. This sometimes results in overheating of bone and overlying tissue during treatment, leading to skin burns. Successful treatment of a patient with tumours in the upper abdomen therefore requires a thorough understanding of the way acoustic and thermal energy is deposited. In this thesis, an approach which predicts the acoustic field of a multi-element HIFU array scattered by human ribs, the topology of which was obtained from CT scan data, has been developed, implemented and validated. It is based on the boundary element method (BEM). Dissipative mechanisms were introduced into the propagating medium, along with a complex surface impedance condition at the surface of the ribs. A reformulation of the boundary element equations as a constrained optimisation problem was carried out to solve the inverse problem of determining the complex surface normal velocities of a multi-element HIFU array that best fitted a required acoustic pressure distribution in a least-squares sense. This was done whilst ensuring that an acoustic dose rate parameter at the surface of the ribs was kept below a specified threshold. The methodology was tested at an excitation frequency of 1 MHz on a spherical section multi-element array in the presence of human ribs. It was compared on six array-rib topologies against other methods of focusing through the ribs, including binarised apodisation based on geometric ray tracing, phase conjugation and the DORT method (décomposition de l’opérateur de retournement temporel). The constrained optimisation approach offers greater potential than the other focusing methods in terms of maximising the ratio of acoustic pressure magnitudes at the focus to those on the surface of the ribs whilst taking full advantage of the dynamic range of the phased array.
2
HARIHARAN, PRASANNA. "Free field characterization of High Intensity Focused Ultrasound (HIFU) transducers using acoustic streaming." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1204570105.
3
Dasgupta, Subhashish. "Improved Characterization of the High Intensity Focused Ultrasound (HIFU) induced Thermal Field." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1275936679.
4
Sanchez, Marine. "Développement d’un transducteur torique extracorporel et du principe de focalisation multi-torique en vue du traitement des adénocarcinomes mammaires par ultrasons focalisés de haute intensité." Electronic Thesis or Diss., Lyon, 2020. http://www.theses.fr/2020LYSE1243.
Анотація:
Les ultrasons focalisés de haute intensité (HIFU) sont reconnus et couramment utilisés dans le domaine médical pour le traitement des tumeurs solides. Cette technique permet une destruction localisée des tissus biologiques par élévation de la température. Ce manuscrit décrit la conception et l’utilisation d’un système thérapeutique et d’une nouvelle solution de focalisation brevetée, ayant pour objectif principal le traitement non invasif des adénocarcinomes mammaires. Dans un premier temps, un dispositif existant destiné au traitement surfacique des métastases hépatiques et en cours d’évaluation clinique a été utilisé. Une étude ex vivo sur échantillons humains de tissu mammaire a permis de montrer la possibilité de déposer de la pression en profondeur de façon non invasive. Basé sur cette étude, le développement d’une nouvelle modalité de focalisation a été entrepris dans le but d’élargir le volume traité sans impliquer des temps de traitement supérieur à la minute et des déplacements mécaniques du dispositif. Cette modalité a permis d’augmenter de 30 % le volume traité par le dispositif existant sans augmenter le temps de traitement. Compte tenu des limites du dispositif existant et de la nouvelle solution à intégrer, un nouveau dispositif a été conçu et fabriqué dans le but de répondre aux besoins des traitements des adénocarcinomes mammaires. La focalisation naturelle de ce transducteur permet de déposer de la pression en profondeur. Si la nouvelle modalité de focalisation électronique est utilisée, un champ de pression élargi est émis, permettant ainsi d’augmenter le volume de traitement. Les performances de cette sonde de traitement ont été évaluées numériquement puis validées lors d’expérimentations préliminaires in vitro sur des tissus hépatiques et lors d’une étude ex vivo sur des échantillons humains de tissu mammaire. Ces travaux représentent la première étape de l’élaboration d’un traitement HIFU pour traiter les adénocarcinomes mammaires avec un dispositif HIFU non-invasif, guidé par échographie et utilisable manuellementHigh Intensity Focused Ultrasound (HIFU) is a technique commonly used in the medical field for the treatment of solid tumors. This therapeutic strategy allows for the localized destruction of biological tissue by temperature elevation. This manuscript describes the design and utilization of a therapeutic system and a novel, patented focalization technique for non-invasive treatment of mammary adenocarcinomas. In a first instance, an existing device that has been previously used for intraoperative treatment of hepatic metastases, and one that is currently undergoing clinical trials, was used. An ex vivo study on human mammary samples demonstrated the possibility of applying pressures on deep tissue layers in a non-invasive manner. Based on this study, the development of a new focalization modality was developed to provide larger treated volumes while yielding treatment times under a minute and eliminating the need for mechanical steering of the device. This new modality provided treated volumes 30% larger than those produced by the existing device with no changes to treatment time. Given the limitations of the existing device, in addition to the need of integrating the new focalization strategy, a new device was designed and specifically fabricated to meet the demands for treating mammary adenocarcinomas. The natural focalization of this novel transducer allows for depositing pressure deep in tissue. When the new focalization modality is used, a larger pressure field produces increased treated volumes. The performance provided by the novel probe was first characterized through modeling studies. These results were then validated through preliminary in vitro studies on hepatic tissues as well as in ex vivo studies on human mammary tissue samples. This work represents the first stage of development of a HIFU treatment for mammary adenocarcinomas using a novel, non-invasive and image-guided HIFU device that can be used manually
5
Vincenot, Jérémy. "Transducteurs toriques peropératoires et extracorporels destinés au traitement des tumeurs hépatiques et pancréatiques par ultrasons focalisés de haute intensité." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10161.
Анотація:
Les ultrasons focalisés de haute intensité (HIFU) permettent la destruction de tissus biologiques par élévation de la température. Cette technique reconnue est utilisée actuellement dans le monde médical afin de traiter certaines masses tumorales. Le projet décrit dans ce document détaille la mise au point et l'utilisation de deux systèmes thérapeutiques indépendants, ayant pour objectif principal le traitement peropératoire puis extracorporel des tumeurs hépatiques. Dans un premier temps, un système chirurgical existant, destiné au traitement des métastases hépatiques et en cours d'évaluation clinique, a été utilisé. La mise en place d'une modalité de traitement par focalisation électronique a permis d'augmenter le volume de coagulation initial et ainsi faciliter la procédure opératoire. Basée sur les conclusions de cette première étude, une seconde version de sonde peropératoire a été modélisée puis développée. La géométrie du transducteur utilisé a permis une modification de la forme des lésions produites. Les performances de cette sonde de traitement ont été évaluées numériquement puis validées lors d'expérience in vitro et in vivo. L'efficacité, la simplicité et la reproductibilité des traitements réalisés sur le foie ont conduit à une possible application du dispositif aux cancers du pancréas. Après étude numérique et évaluation de la faisabilité in vitro, une validation sur modèle animal a été entreprise. L'ensemble des résultats obtenus au cours de ces différents traitements peropératoires a permis d'envisager la faisabilité d'un dispositif de traitement par voie extracorporelle. Une étude théorique a donné lieu à la réalisation d'un prototype expérimental. Après calibrations et étalonnages, des résultats in vitro préliminaires ont été obtenusHigh intensity focused ultrasound (HIFU) allows the destruction of biological tissue by temperature increase. This technique is commonly used in the medical world for treating certain types of tumor masses. The project described in this document details the development and use of two independent therapy systems, with the main objective to treat intraoperatively and extracorporeally liver tumors. As a first step, an existing surgical system, intended to treat liver metastases and under clinical evaluation, was used. The establishment of a treatment modality based on electronic focusing has contributed to increase the coagulation volume and thus simplify the operative procedure. Based upon the findings of this first study, a second version of intraoperative probe was modeled and developed. The geometry of this new transducer allowed to change the shape of produced ablations. The performance of this probe were evaluated numerically and then validated with in vitro and in vivo studies. The effectiveness, simplicity and reproducibility of the treatments performed in the liver led to a possible application of the device to pancreatic cancer. After numerical study and in vitro feasibility assessment, animal model validation was also undertaken. All the results obtained during the peroperative treatments was used to study the feasibility of an extracorporeal treatment. A theoretical study has led to the development of an experimental prototype. After calibration, preliminary in vitro results were obtained
6
Vincenot, Jérémy. "Transducteurs toriques peropératoires et extracorporels destinés au traitement des tumeurs hépatiques et pancréatiques par ultrasons focalisés de haute intensité." Electronic Thesis or Diss., Lyon 1, 2013. http://www.theses.fr/2013LYO10161.
Анотація:
Les ultrasons focalisés de haute intensité (HIFU) permettent la destruction de tissus biologiques par élévation de la température. Cette technique reconnue est utilisée actuellement dans le monde médical afin de traiter certaines masses tumorales. Le projet décrit dans ce document détaille la mise au point et l'utilisation de deux systèmes thérapeutiques indépendants, ayant pour objectif principal le traitement peropératoire puis extracorporel des tumeurs hépatiques. Dans un premier temps, un système chirurgical existant, destiné au traitement des métastases hépatiques et en cours d'évaluation clinique, a été utilisé. La mise en place d'une modalité de traitement par focalisation électronique a permis d'augmenter le volume de coagulation initial et ainsi faciliter la procédure opératoire. Basée sur les conclusions de cette première étude, une seconde version de sonde peropératoire a été modélisée puis développée. La géométrie du transducteur utilisé a permis une modification de la forme des lésions produites. Les performances de cette sonde de traitement ont été évaluées numériquement puis validées lors d'expérience in vitro et in vivo. L'efficacité, la simplicité et la reproductibilité des traitements réalisés sur le foie ont conduit à une possible application du dispositif aux cancers du pancréas. Après étude numérique et évaluation de la faisabilité in vitro, une validation sur modèle animal a été entreprise. L'ensemble des résultats obtenus au cours de ces différents traitements peropératoires a permis d'envisager la faisabilité d'un dispositif de traitement par voie extracorporelle. Une étude théorique a donné lieu à la réalisation d'un prototype expérimental. Après calibrations et étalonnages, des résultats in vitro préliminaires ont été obtenusHigh intensity focused ultrasound (HIFU) allows the destruction of biological tissue by temperature increase. This technique is commonly used in the medical world for treating certain types of tumor masses. The project described in this document details the development and use of two independent therapy systems, with the main objective to treat intraoperatively and extracorporeally liver tumors. As a first step, an existing surgical system, intended to treat liver metastases and under clinical evaluation, was used. The establishment of a treatment modality based on electronic focusing has contributed to increase the coagulation volume and thus simplify the operative procedure. Based upon the findings of this first study, a second version of intraoperative probe was modeled and developed. The geometry of this new transducer allowed to change the shape of produced ablations. The performance of this probe were evaluated numerically and then validated with in vitro and in vivo studies. The effectiveness, simplicity and reproducibility of the treatments performed in the liver led to a possible application of the device to pancreatic cancer. After numerical study and in vitro feasibility assessment, animal model validation was also undertaken. All the results obtained during the peroperative treatments was used to study the feasibility of an extracorporeal treatment. A theoretical study has led to the development of an experimental prototype. After calibration, preliminary in vitro results were obtained
7
Cambronero, Sophie. "Développement d’un traitement non invasif des tumeurs hépatiques par ultrasons focalisés." Electronic Thesis or Diss., Lyon 1, 2022. http://www.theses.fr/2022LYO10234.
Анотація:
Les ultrasons focalisés de haute intensité (HIFU) sont une modalité de traitement non invasive des tumeurs solides qui permet une destruction tissulaire localisée et en profondeur des tissus. Les travaux de ce manuscrit décrivent le développement de stratégies de traitement et la conception d’un transducteur de géométrie torique dédié au traitement non invasif des tumeurs hépatiques. Dans un premier temps, un dispositif HIFU torique existant et conçu pour le traitement peropératoire des tumeurs hépatiques a été utilisé afin d’élargir les perspectives de traitement peropératoire pour les tumeurs localisées au confluent cavo-sus-hépatique. Cette approche de traitement a été évaluée sur une étude préclinique et a montré la faisabilité de la procédure et la tolérance à moyen du traitement. Ce même dispositif a ensuite été utilisé pour déterminer la faisabilité d’un traitement HIFU complètement non invasif avec un transducteur de géométrie torique. La faisabilité et l’innocuité de ce traitement non invasif a été démontré sur une étude préclinique chez le modèle porcin. Ces travaux ont mis en lumière la nécessité d’une personnalisation des traitements HIFU non invasif afin d’épargner les tissus intermédiaires sains. Sur la base de ces expériences, un nouveau système de ciblage a été développer afin d’assurer un ciblage précis des traitements HIFU non invasifs réalisés proches de structures à risques. Les performances de nouveau système ont été démontré sur deux protocoles in vivo pour le traitement du STT (Syndrome Transfuseur Transfusé) et des tumeurs du trigone vésical. Un nouveau dispositif de traitement HIFU a ensuite été conçu et développé pour le traitement non invasif des tumeurs hépatiques. La découpe spécifique de ce transducteur torique tronqué permet un élargissement du volume traité sans déplacement mécanique du transducteur. Les performances thérapeutiques de ce dispositif ont été évaluées sur des essais in vitro et in vivo chez le modèle porcin. Ces travaux représentent la première brique d’un traitement non invasif des tumeurs hépatiques avec un transducteur HIFU toriqueHigh-intensity focused ultrasound (HIFU) is a non-invasive treatment modality for solid tumors that provides a localized destruction of deep tissues. The work in this manuscript describes the development of treatment strategies and the design of a toroidal HIFU transducer dedicated to the non-invasive treatment of liver tumors. First, an existing toroidal HIFU device designed for an intraoperative treatment of liver tumors was used to expand the prospects for intraoperative treatment of tumors localized at the hepato-caval confluence. This treatment approach was evaluated in a preclinical study and showed the feasibility of the procedure and the tolerance of the treatment. This same device was then used to evaluate the feasibility of a completely non-invasive HIFU treatment with a toroidal transducer. The feasibility and safety of this non-invasive treatment was demonstrated in a preclinical study in the porcine model. This work highlighted the need for personalized non-invasive HIFU treatments to spare healthy intermediate tissues. Based on these experiences, a new targeting system was developed to ensure an accurate targeting of non-invasive HIFU treatments performed near risky structures. The performance of the new system has been demonstrated on two in vivo protocols for the treatment of the TTTS (Twin to Twin Transfusion Syndrome) and bladder trigone tumors. A new HIFU treatment device was then designed and developed for the non-invasive treatment of liver tumors. The specific cut of this truncated toroidal transducer allows an enlargement of the treated volume without mechanical displacement of the transducer. The therapeutic performance of this device has been evaluated on in vitro and in vivo experiments in the porcine model. This work represents the first step of a non-invasive treatment of hepatic tumors with a toroidal HIFU transducer
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Dibaji, Seyed Ahmad Reza. "Nonlinear Derating of High Intensity Therapeutic Ultrasound Beams using Decomposition of Gaussian Mode." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1458900246.
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Masárová, Mária. "Evoluční návrh ultrazvukových operačních plánů." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2021. http://www.nusl.cz/ntk/nusl-445547.
Анотація:
Použitie zameraného ultrazvuku pomáha zachraňovať a uľahčovať ľudské životy, nakoľko práve jeho využitím môžeme liečiť epilepsiu, ničiť rakovinové bunky a zastavovať vnútorné krvácanie neinvazívnou cestou, ktorá predstavuje pre človeka prijateľnejšie a bezpečnejšie riešenie. Vzhľadom na to, že bezpečnosť a zdravie človeka je prioritou pri liečení závažných ochorení, sa táto práca zaoberá porovnaním rôznych evolučných algoritmov a ich použitím pri návrhu evolučných ultrazvukových operačných plánov. V práci sa využívajú dva typy médií, a to homogénne médium a heterogénne médium. Pri vyhodnocovaní algoritmov sa zameriavame na efektivitu s ohľadom na veľkosť populácie, počet evaluácií fitness funkcie a výpočetný čas. V homogénnom médiu sa ako najlepší algoritmus ukázal CMA-ES, ktorý v priebehu 20 sekúnd dokázal nájsť optimálne riešenie so 100% pokrytím cieľovej oblasti pre rotované zrnko ryže. Heterogénne médium je ale oveľa zložitejší problém, predovšetkým kvôli lebke, ktorá odráža a pohlcuje veľkú časť ultrazvuku. Tu sa ako najlepší preukázal algoritmus SA, ktorý našiel výsledok s 23% pokrytím cieľovej oblasti v prvom testovacom scenári. Doba výpočtu trvala približne 1 hodinu a 18 minút, čo značí že je čas veľmi znemožňujúci ("drahý") faktor.
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Wang, Xusheng. "Ultrasonic Generator for Surgical Applications and Non-invasive Cancer Treatment by High Intensity Focused Ultrasound." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS052/document.
Анотація:
La technique de haute intensité ultrasons focalisés (HIFU) est maintenant largement utilisée pour le traitement du cancer, grâce à son avantage non-invasif. Dans un système de HIFU, une matrice de transducteurs à ultrasons est pilotée en phase pour produire un faisceau focalisé d'ultrasons (1M ~ 10 MHz) dans une petite zone de l'emplacement de la cible sur le cancer dans le corps. La plupart des systèmes HIFU sont guidées par imagerie par résonance magnétique (IRM) dans de nos jours. Dans cette étude de doctorat, un amplificateur de puissance de classe D en demi-pont et un système d'accord automatique d'impédance sont proposés. Tous deux circuits proposés sont compatibles avec le système IRM. L'amplificateur de puissance proposé a été réalisé par un circuit imprimé (PCB) avec des composants discrets. Selon les résultats du test, il a rendement de conversion en puissance de 82% pour une puissance de sortie conçue de 1,25W à une fréquence de travail de 3MHz. Le système d'accord automatique d'impédance proposé a été conçu en deux versions: une version en PCB et une version en circuit intégré (IC). Contrairement aux systèmes d'accord automatique proposés dans la littérature, il n'y a pas besoin de l'unité de microcontrôleur (MCU) ou de l'ordinateur dans la conception proposée. D'ailleurs, sans l'aide de composants magnétiques volumineux, ce système d'auto-réglage est entièrement compatible avec l'équipement IRM. La version en PCB a été conçue pour vérifier le principe du système proposé, et il est également utilisé pour guider à la conception du circuit intégré. La réalisation en PCB occupe une surface de 110cm². Les résultats des tests ont confirmé la performance attendue. Le système d'auto-tuning proposé peut parfaitement annuler l'impédance imaginaire du transducteur, et il peut également compenser l'impédance de la dérive causée par les variations inévitables (variation de température, dispersion technique, etc.). La conception du système d'auto-réglage en circuit intégré a été réalisé avec une technologie CMOS (C35B4C3) fournies par Austrian Micro Systems (AMS). La surface occupée par le circuit intégré est seulement de 0,42mm². Le circuit intégré conçu est capable de fonctionner à une large gamme de fréquence tout en conservant une consommation d'énergie très faible (137 mW). D'après les résultats de la simulation, le rendement de puissance de ce circuit peut être amélioré jusqu'à 20% comparant à celui utilisant le réseau d'accord statiqueHigh intensity focused ultrasound (HIFU) technology is now broadly used for cancer treatment, thanks to its non-invasive property. In a HIFU system, a phased array of ultrasonic transducers is utilized to generate a focused beam of ultrasound (1M~10MHz) into a small area of the cancer target within the body. Most HIFU systems are guided by magnetic resonance imaging (MRI) in nowadays. In this PhD study, a half-bridge class D power amplifier and an automatic impedance tuning system are proposed. Both the class D power amplifier and the auto-tuning system are compatible with MRI system. The proposed power amplifier is implemented by a printed circuit board (PCB) circuit with discrete components. According to the test results, it has a power efficiency of 82% designed for an output power of 3W at 1.25 MHz working frequency. The proposed automatic impedance tuning system has been designed in two versions: a PCB version and an integrated circuit (IC) version. Unlike the typical auto-impedance tuning networks, there is no need of microprogrammed control unit (MCU) or computer in the proposed design. Besides, without using bulky magnetic components, this auto-tuning system is completely compatible with MRI equipment. The PCB version was designed to verify the principle of the proposed automatic impedance tuning system, and it is also used to help the design of the integrated circuit. The PCB realization occupies a surface of 110cm². The test results confirmed the expected performance. The proposed auto-tuning system can perfectly cancel the imaginary impedance of the transducer, and it can also compensate the impedance drifting caused by unavoidable variations (temperature variation, technical dispersion, etc.). The IC design of the auto-tuning system is realized in a CMOS process (C35B4C3) provided by Austrian Micro Systems (AMS). The die area of the integrated circuit is only 0.42mm². This circuit design can provide a wide working frequency range while keeping a very low power consumption (137 mW). According to the simulation results, the power efficiency can be improved can up to 20% by using this auto-tuning circuit compared with that using the static tuning network
Частини книг з теми "HIFU transducer":
1
García-López, Juan Carlos, Raquel Martínez-Valdez, Citlalli J. Trujillo-Romero, Arturo Vera, and Lorenzo Leija. "Frequency Parametric Study for a HIFU Transducer Intended for Bone Tumor Treatment." In IFMBE Proceedings, 1253–60. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-30648-9_162.
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Rybyanets, A. N., A. A. Naumenko, N. A. Shvetsova, V. A. Khokhlova, O. A. Sapozhnikov, and A. E. Berkovich. "Theoretical Modeling and Experimental Study of HIFU Transducers and Acoustic Fields." In Springer Proceedings in Physics, 621–37. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-26324-3_44.
Тези доповідей конференцій з теми "HIFU transducer":
1
Park, Chan Yuk, Da Sol Kwon, Jin Ho Sung, and Jong Seob Jeong. "High Intensity Focused Ultrasound Transducer Using Inversion Layer Technique for Ultrasound Therapy." In 2017 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dmd2017-3369.
Анотація:
Recently, high intensity focused ultrasound (HIFU) has been used for non-invasive surgery of prostate, uterus, and brain. However, a HIFU therapy is suffered from relatively long surgical time mainly due to small focal area per each sonication. In order to solve this problem, a HIFU therapy using multi-frequency was suggested by several researchers, and they demonstrated that this technique can increase the area of the coagulated lesion due to enhanced cavitation effect compared to single-frequency HIFU [1–3]. To generate multi-frequency especially dual-frequency, dual-element and dual-layer HIFU transducers have been developed and provided an expanded lesion size [1–3]. In this study, we present an alternative technique of making dual-frequency HIFU transducer using inversion layer technique. Generally, a single layer piezoelectric element can excite the strong fundamental resonance (f0) and the weak odd-order harmonic resonance (3f0) [4]. In the inversion layer technique, on the other hand, a piezoelectric component consisting of two piezo-ceramic plates bonded together with opposite poling directions and different thicknesses can produce the relatively strong even-order harmonic (2f0) in addition to the fundamental resonance [5]. Additionally, only a pair of electrode at the outside of the each piezo-ceramic plate is required to stimulate dual-frequency ultrasound while two pairs of electrodes are typically required for conventional dual-element and dual-layer transducers [2,3]. A specially designed prototype HIFU transducer was built, and we verified that the dual-frequency ultrasound was successfully generated through electrical impedance and pulse-echo response measurements.
2
Jungsoon Kim, Moojoon Kim, and Kanglyeol Ha. "HIFU transducer with controllable curvature." In 2013 IEEE International Ultrasonics Symposium (IUS). IEEE, 2013. http://dx.doi.org/10.1109/ultsym.2013.0290.
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Rivens, Ian. "A Phased Strip Array HIFU Transducer." In THERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound. AIP, 2006. http://dx.doi.org/10.1063/1.2205510.
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Fleury, Gérard. "Safety Issues for HIFU Transducer Design." In 4TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND. AIP, 2005. http://dx.doi.org/10.1063/1.1901645.
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Melodelima, David, William A. N'Djin, Hubert Parmentier, Michel Rivoire, and Jean-Yves Chapelon. "Toric HIFU Transducer for Large Thermal Ablation." In 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2007. http://dx.doi.org/10.1109/iembs.2007.4352265.
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Dibaji, Seyed Ahmad Reza, and Rupak K. Banerjee. "Influence of the Transducer Acoustic Power on Focal Location of the Beam During HIFU Ablation Procedure." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80830.
Анотація:
The location of High Intensity Focused Ultrasound (HIFU) beam in a tissue medium is an important parameter in assessment of the thermal field as it influences the temperature rise in the tissue. Our hypothesis is that the location of the beam can be affected by the power of the transducer. HIFU procedure with 30s of sonication time was performed at different powers of transducer (5 to 60 W) as well as different initial locations of beam in a tissue mimicking material. Eight thermocouples were embedded at 4 different layers in a phantom to measure the temperature rise during HIFU procedure. An inverse method based on experimental data and optimization algorithm was used to find the actual location of beam based on the experimental data. Our experimental data showed that for a higher power (60 W) as compared to a lower power (5 W), the focal distance that the actual position of beam moves away from its initial location increased with the raise in power. Thus, beam location can change at different powers of transducer. Using inverse method we showed that there is a direct linear correlation (R2 = 0.95) between the transducer power and the distance that beam moves away from its initial location. Therefore, it is of great clinical importance to study the effects of transducer power on the location of HIFU beam in an attempt to minimize the damage to healthy cells.
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Wong, Wai, Carlos Christoffersen, Samuel Pichardo, and Laura Curiel. "An integrated ultrasound transducer driver for HIFU applications." In 2013 26th IEEE Canadian Conference on Electrical and Computer Engineering (CCECE). IEEE, 2013. http://dx.doi.org/10.1109/ccece.2013.6567791.
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Howard, Samuel M., and Claudio I. Zanelli. "HIFU Transducer Characterization Using a Robust Needle Hydrophone." In 6TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND. AIP, 2007. http://dx.doi.org/10.1063/1.2744244.
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Christoffersen, Carlos, Thinh Ngo, Ruiqi Song, Yushi Zhou, Samuel Pichardo, and Laura Curiel. "Quasi Class-DE Driving of HIFU Transducer Arrays." In 2020 IEEE International Symposium on Circuits and Systems (ISCAS). IEEE, 2020. http://dx.doi.org/10.1109/iscas45731.2020.9180423.
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N’Djin, W. A., D. Melodelima, F. Schenone, M. Rivoire, J. Y. Chapelon, Kullervo Hynynen, and Jacques Souquet. "Segmental liver resection assisted by HIFU: tissue precauterization using a toroidal-shaped HIFU transducer." In 9TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND: ISTU—2009. AIP, 2010. http://dx.doi.org/10.1063/1.3367204.