Дисертації з теми "Heterogeneous disease"
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Lamouroux, David. "Cyclic Dynamics of Spatially Heterogeneous Populations - From Biodiversity to Disease Prevalence." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F289-9.
Повний текст джерелаHandel, Adam E. "Functional genomics approaches to understanding heterogeneous tissues in health and disease." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:a8ceeb0d-8526-45ef-9ade-6da3b5cc5f99.
Повний текст джерелаYang, Sen. "Disease, Drug, and Target Association Predictions by Integrating Multiple Heterogeneous Sources." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1342194249.
Повний текст джерелаBrown, Grant Donald. "Application Of Heterogeneous Computing Techniques To Compartmental Spatiotemporal Epidemic Models." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1554.
Повний текст джерелаNagoski, Emily. "An agent based model of disease diffusion in the context of heterogeneous sexual motivation." [Bloomington, Ind.] : Indiana University, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3223076.
Повний текст джерела"Title from dissertation home page (viewed July 2, 2007)." Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3087. Advisers: David Lohrmann; Erick Janssen.
Kamath, Tarun(Tarun Vinod). "Tau aggregation is heterogeneous across cases of sporadic Alzheimer's disease and is influenced by autophagy pathways in vitro." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/127885.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references (pages. 85-97).
Tau neurofibrillary tangles or aggregates are a common neuropathological feature found in a number of neurodegenerative conditions, including Alzheimer's disease. Understanding the kinetics of this aggregate build up, how it varies across patients, and how aggregation might be influenced by intracellular pathways is critical for both a deeper knowledge of these disorders as well as identification of potential therapeutic targets. To this end, I employed an in vitro tau aggregation assay to study the kinetics of tau aggregation as it relates to aggregates in sporadic Alzheimer's disease. I found that the formation of aggregates was a logistic process, with a lag phase, an exponential rise phase, and a plateau phase. Aggregation kinetics varied significantly between different cases of sporadic Alzheimer's disease, paralleling the heterogeneity that is observed in the clinical presentation of Alzheimer's disease. Likewise, I found that inhibition of intracellular pathways of macroautophagy and endosomal microautopahgy heterogeneously increased tau aggregation and changed tau aggregation kinetics, dependent upon the case of Alzheimer's disease. These results inform that tau aggregates vary significantly not just between disorders, but even within disorders, and that protein degradation pathways uniquely process aggregates, perhaps potentiated by further molecular differences in aggregate structure or composition.
by Tarun Kamath.
M. Eng.
M.Eng. Massachusetts Institute of Technology, Department of Biological Engineering
Bravo-Salgado, Angel D. "Modeling and Simulation of the Vector-Borne Dengue Disease and the Effects of Regional Variation of Temperature in the Disease Prevalence in Homogenous and Heterogeneous Human Populations." Thesis, University of North Texas, 2016. https://digital.library.unt.edu/ark:/67531/metadc862802/.
Повний текст джерелаNichols, Carol Anne. "The Influence of Heterogeneous Landscapes on Banded Mongoose (Mungos mungo) Behavior in Northern Botswana: Inferences about Infectious Disease Transmission." Thesis, Virginia Tech, 2018. http://hdl.handle.net/10919/95936.
Повний текст джерелаM. S.
Zhu, Cheng. "Efficient network based approaches for pattern recognition and knowledge discovery from large and heterogeneous datasets." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1378215769.
Повний текст джерелаLamouroux, David Verfasser], Theo [Akademischer Betreuer] [Geisel, and Reiner [Akademischer Betreuer] Kree. "Cyclic Dynamics of Spatially Heterogeneous Populations - From Biodiversity to Disease Prevalence / David Lamouroux. Gutachter: Theo Geisel ; Reiner Kree. Betreuer: Theo Geisel." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://d-nb.info/1044361166/34.
Повний текст джерелаGorgoglione, Bartolomeo. "Heterogeneous infections in fish : transcriptomic studies on the trout immune response to single and co-infections." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=210706.
Повний текст джерелаAl, Mashhadani Mahmood Yaseen Hachim [Verfasser]. "The use of integrative OMICs to decipher heterogeneous chronic complex disease mechanism : severe asthma as a model / Mahmood Yaseen Hachim Al Mashhadani." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2021. http://d-nb.info/1227545096/34.
Повний текст джерелаMontazeri, Shahtori Narges. "Quantifying the impact of contact tracing on ebola spreading." Thesis, Kansas State University, 2016. http://hdl.handle.net/2097/34540.
Повний текст джерелаDepartment of Electrical and Computer Engineering
Faryad Darabi Sahneh
Recent experience of Ebola outbreak of 2014 highlighted the importance of immediate response to impede Ebola transmission at its very early stage. To this aim, efficient and effective allocation of limited resources is crucial. Among standard interventions is the practice of following up with physical contacts of individuals diagnosed with Ebola virus disease -- known as contact tracing. In an effort to objectively understand the effect of possible contact tracing protocols, we explicitly develop a model of Ebola transmission incorporating contact tracing. Our modeling framework has several features to suit early–stage Ebola transmission: 1) the network model is patient–centric because when number of infected cases are small only the myopic networks of infected individuals matter and the rest of possible social contacts are irrelevant, 2) the Ebola disease model is individual–based and stochastic because at the early stages of spread, random fluctuations are significant and must be captured appropriately, 3) the contact tracing model is parameterizable to analyze the impact of critical aspects of contact tracing protocols. Notably, we propose an activity driven network approach to contact tracing, and develop a Monte-Carlo method to compute the basic reproductive number of the disease spread in different scenarios. Exhaustive simulation experiments suggest that while contact tracing is important in stopping the Ebola spread, it does not need to be done too urgently. This result is due to rather long incubation period of Ebola disease infection. However, immediate hospitalization of infected cases is crucial and requires the most attention and resource allocation. Moreover, to investigate the impact of mitigation strategies in the 2014 Ebola outbreak, we consider reported data in Guinea, one the three West Africa countries that had experienced the Ebola virus disease outbreak. We formulate a multivariate sequential Monte Carlo filter that utilizes mechanistic models for Ebola virus propagation to simultaneously estimate the disease progression states and the model parameters according to reported incidence data streams. This method has the advantage of performing the inference online as the new data becomes available and estimating the evolution of the basic reproductive ratio R₀(t) throughout the Ebola outbreak. Our analysis identifies a peak in the basic reproductive ratio close to the time of Ebola cases reports in Europe and the USA.
Hallow, Karen Melissa. "Relationships between Mechanical Stress and Markers of Inflammation in Diseased Human Coronary Arteries." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/16211.
Повний текст джерелаDarbon, Alexandre. "Épidémiologie sur réseau pour l'évaluation des risques dans la prévention et le contrôle des infections Network-based assessment of the vulnerability of Italian regions to bovine brucellosis Disease persistence on temporal contact networks accounting for heterogeneous infectious periods." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS077.
Повний текст джерелаMy doctoral thesis aims to propose solutions against the spread of infectious diseases in specific contexts, taking into account how host contacts evolve in time using a temporal network representation. It focuses on the determination of the epidemic threshold, a key indicator of the epidemic risk. By leveraging and extending a mathematical formalism from network theory, this work enables the computation of the epidemic threshold in real situations in order to identify public health measures. A first project addresses the persistence of bovine brucellosis in Italy despite the existing eradication measures. Using comprehensive data on cattle movements between Italian farms over several years, as well as time-stamped outbreak records, the epidemic threshold computation in each region of the country provides information on regions vulnerability and proposes factors that may explain disease persistence. An extension of the formalism is then presented, including heterogeneous average infectious periods in the epidemic threshold computation. This work shows in different epidemiological contexts how the classical assumption that the average infectious period is the same for all hosts in a population may bias epidemic risk assessments. This method also identifies the hosts in a population that are primarily responsible for the global epidemic risk
Russell, Colin Andrew. "Dynamics of acute infectious diseases in heterogeneous environments." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614196.
Повний текст джерелаBeattie, Deborah Kilpatrick. "The mechanics of heterogeneous arteries : implications for human atherosclerosis." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/20498.
Повний текст джерелаZolotareva, Olga [Verfasser]. "Identification of Differentially Expressed Gene Modules in Heterogeneous Diseases / Olga Zolotareva." Bielefeld : Universitätsbibliothek Bielefeld, 2021. http://d-nb.info/1232913588/34.
Повний текст джерелаGomez-Lopez, Iris Nelly. "Simulating the Spread of Infectious Diseases in Heterogeneous Populations with Diverse Interactions Characteristics." Thesis, University of North Texas, 2013. https://digital.library.unt.edu/ark:/67531/metadc407831/.
Повний текст джерелаHernández-Luna, Yezid. "International trade and labor markets : empirical and theoretical evidence." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0547.
Повний текст джерелаI study the relationship between international trade and labor markets in three papers. In the first one, I find for the Colombian case, that together, the sector skill intensity and the international trade bring about more skill-biased technical change, increasing wage inequality, though such an effect is offset using temporary workers. In the second one, the analysis of a trade model with formal and informal heterogeneous firms, under full employment, shows that an openness policy decreases the average productivity of informal firms while makes formal to become informal, worsening welfare. However, forcing informal firms to become formal, increases average wages and raises welfare. In the third one, Diff in Diff estimates presents the impact of the 2003-2013 oil prices boom, on countries affected and not affected by the Dutch disease. In the former group, international trade flow increases although agriculture at a lower magnitude, while unemployment and informal labor decrease
Lambert, Sébastien. "Transmission and management of brucellosis in a heterogeneous wild population of Alpine ibex (Capra ibex)." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1278.
Повний текст джерелаThe management of infectious diseases in wildlife reservoirs is particularly challenging and faces several limitations. The development of appropriate management strategies requires a detailed understanding of the factors affecting the transmission and persistence of the infectious agent in the population. Among these factors, heterogeneity of transmission is a common characteristic in natural host-pathogen systems. Indeed, wild animals express a broad range of behaviours, are organised in a variety of social and spatial structures, occupy many areas with very different characteristics and belong to a large diversity of species. Such heterogeneities, from between-individuals to between-species, may result in different contributions to the overall number of new cases of infections. Thus, understanding transmission heterogeneity could provide valuable insights on how to effectively manage these systems, by targeting the individuals or areas that are responsible for most transmissions. The aim of this thesis was to provide insights on the monitoring and management of infectious diseases in heterogeneous wild populations, using Brucella melitensis infection in a French population of wild Alpine ibex (Capra ibex) as a case study. The biology of brucellosis and the ecology of Alpine ibex makes this case study a good candidate for transmission heterogeneity at several levels. Using bacterial examinations, we first established that only 58% of seropositive individuals were at risk to excrete Brucella, and that this risk decreased with increasing age. Then, we took advantage of detailed information available on ibex population dynamics, behaviour, and habitat use, and on epidemiological surveys, to build an individual-based model in order to quantify heterogeneity at the individual and spatial levels. The transmission is extremely heterogeneous between individuals, with females generating around 90% of the new cases of brucellosis infection, and between spatial units, three of the five socio-spatial units (the core area) accounting for more than 80% of brucellosis transmission. Using statistical models to estimate the temporal dynamics of the seroprevalence and of the force of infection in the population, we found evidence that the massive captures with test-and-remove operations that were conducted in 2015 managed to reduce brucellosis transmission in the population. Based on these results, we evaluated several predictive disease management strategies in the individual-based model. Our results confirmed that the primary strategy should be to remove as many seropositive individuals as possible, and that strategies targeting females and/or the core area are more effective than untargeted management. Although there is no silver bullet for the management of brucellosis in the population of study, targeted strategies offer a wide range of promising refinements to classical sanitary measures. We therefore encourage to look for heterogeneity in other infection-wildlife systems and to evaluate potential targeted strategies for improving management schemes in terms of efficiency and acceptability
Chénard, Carol Anne. "Ribonucleoprotein complexes and protein arginine methylation : a role in diseases of the central nervous sytem." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115894.
Повний текст джерелаQKI's involvement in all of these processes, lead us to examine both the protein partners and the mRNA targets of the QKI complex in order to identify potentially new pathways regulated by QKI. In doing so, we identified a novel direct protein-protein interaction with PABP and for the first time described the relocalization of QKI to cytoplasmic granules following oxidative stress. In addition, in vivo mRNA interaction studies were performed and allowed the identification of approximately 100 new mRNA targets in human glioblastoma cells. One of the targets identified was VEGF mRNA.
Another QKI target mRNA is MBP, a major protein component of the myelin sheath and the candidate auto-antigen in multiple sclerosis (MS). In vivo MBP is symmetrically dimethylated on a single arginine residue. To further establish the role of the methylation of MBP in myelination, a methyl-specific antibody and an adenovirus expressing a recombinant protein arginine methyltransferase 5 (PRMT5) was generated. We show that methylated MBP is found in areas of mature myelin and that overexpression of the PRTM5 blocked the differentiation of oligodendrocytes.
Taken together these datas implicate QKI for the first time in the process of human cancer angiogenesis and could explain the vascularization defects observed in some of the qkI mutant mice. In addition, arginine methylation of MBP may prove to have an important role in the process of myelination and in the pathogenesis of demyelination and the autoimmune reaction in diseases such as MS.
Peixoto, Daniela Alexandra Silva. "Arilação intramolecular catalítica de iminas e análogos: potenciais fármacos para as doenças neurodegenerativas." Doctoral thesis, Universidade de Évora, 2015. http://hdl.handle.net/10174/18413.
Повний текст джерелаTavares, Lucas Alves. "O envolvimento da proteína adaptadora 1 (AP-1) no mecanismo de regulação negativa do receptor CD4 por Nef de HIV-1." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-06012017-113215/.
Повний текст джерелаThe Human Immunodeficiency Virus (HIV) is the etiologic agent of Acquired Immunodeficiency Syndrome (AIDS). AIDS is a disease which has a global distribution, and it is estimated that there are currently at least 36.9 million people infected with the virus. During the replication cycle, HIV promotes several changes in the physiology of the host cell to promote their survival and enhance replication. The fast progression of HIV-1 in humans and animal models is closely linked to the function of an accessory protein Nef. Among several actions of Nef, one is the most important is the down-regulation of proteins from the immune response, such as the CD4 receptor. It is known that this action causes CD4 degradation in lysosome, but the molecular mechanisms are still incompletely understood. Nef forms a tripartite complex with the cytosolic tail of the CD4 and adapter protein 2 (AP-2) in clathrin-coated vesicles, inducing CD4 internalization and lysosome degradation. Previous research has demonstrated that CD4 target to lysosomes by Nef involves targeting of this receptor to multivesicular bodies (MVBs) pathway by an atypical mechanism because, although not need charging ubiquitination, depends on the proteins from ESCRTs (Endosomal Sorting Complexes Required for Transport) machinery and the action of Alix, an accessory protein ESCRT machinery. It has been reported that Nef interacts with subunits of AP- 1, AP-2, AP-3 complexes and Nef does not appear to interact with AP-4 and AP-5 subunits. However, the role of Nef interaction with AP-1 or AP-3 in CD4 down-regulation is poorly understood. Furthermore, AP-1, AP-2 and AP-3 are potentially heterogeneous due to the existence of multiple subunits isoforms encoded by different genes. However, there are few studies to demonstrate if the different combinations of APs isoforms are form and if they have distinct functional properties. This study aim to identify and characterize cellular factors involved on CD4 down-modulation induced by Nef from HIV-1. More specifically, this study aimed to characterize the involvement of AP-1 complex in the down-regulation of CD4 by Nef HIV-1 through the functional study of the two isoforms of ?-adaptins, AP-1 subunits. By pull-down technique, we showed that Nef is able to interact with ?2. In addition, our data from immunoblots indicated that ?2- adaptin, not ?1-adaptin, is required in Nef-mediated targeting of CD4 to lysosomes and the ?2 participation in this process is conserved by Nef from different viral strains. Furthermore, by flow cytometry assay, ?2 depletion, but not ?1 depletion, compromises the reduction of surface CD4 levels induced by Nef. Immunofluorescence microscopy analysis also revealed that ?2 depletion impairs the redistribution of CD4 by Nef to juxtanuclear region, resulting in CD4 accumulation in primary endosomes. Knockdown of ?1A, another subunit of AP-1, resulted in decreased cellular levels of ?1 and ?2 and, compromising the efficient CD4 degradation by Nef. Moreover, upon artificially stabilizing ESCRT-I in early endosomes, via overexpression of HRS, internalized CD4 accumulates in enlarged HRS-GFP positive endosomes, where co-localize with ?2. Together, the results indicate that ?2-adaptin is a molecule that is essential for CD4 targeting by Nef to ESCRT/MVB pathway, being an important protein in the endo-lysosomal system. Furthermore, the results indicate that ?-adaptins isoforms not only have different functions, but also seem to compose AP-1 complex with distinct cell functions, and only the AP-1 variant comprising ?2, but not ?1, acts in the CD4 down-regulation induced by Nef. These studies contribute to a better understanding on the molecular mechanisms involved in Nef activities, which may also help to improve the understanding of the HIV pathogenesis and the related syndrome. In addition, this work contributes with the understanding of primordial process regulation on intracellular trafficking of transmembrane proteins.
Chen, Yan-Ting, and 陳彥廷. "Gastroesophageal Reflux Disease Diagnosis Using Hierarchical Heterogeneous Descriptor Fusion." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/qchxhj.
Повний текст джерела國立中興大學
資訊科學與工程學系所
101
A new computer-aided diagnosis method is proposed to diagnose gastroesophageal reflux disease (GERD) from endoscopic images of the esophageal-gastric junction. To avoid the inferences of endoscope devices and automatic camera white balance adjustment, multiple color invariant models are used to represent endoscopic images. Then, visual vocabularies are built from each color model to describe the mucosa of the esophageal-gastric junction for support vector machine training. To simultaneously consider the prediction results of each color model, a hierarchical support vector machine scheme is proposed. During validation, visual vocabularies extracted from the test endoscopic image are used as the input of the hierarchical support vector machine to diagnose GERD. As shown in the experiments, our method can automatically diagnose GERD without any manual selection of region of interest and achieve better accuracy compared to methods using only one color invariant model.
Huang, Yu-Fen, and 黃玉芬. "Inferring Drug-Disease Associations from Chemical, Genomic and Disease Phenotype Data Using Heterogeneous Network Propagation." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/63230664966352052537.
Повний текст джерела國立清華大學
資訊系統與應用研究所
101
During the last few years, the knowledge of drug, disease phenotype and protein has been rapidly accumulated and more and more scientists have been draw attention to inferring drug-disease associations by computational method. Development of an integrated approach for systematic discovering drug-disease associations by those informational data is an important issue. We combine three weighted networks of drug, genomic and disease phenotype data from available experimental data and knowledge then infer drug-disease associations by a hetero-network propagation approach. In the experiments, we adopt prostate cancer and colorectal cancer as our test data. We select the manually curated associations from comparative toxicogenomics database as our benchmark. The ranked results show that our proposed method obtains high specificity and sensitivity and clearly outperforms previous methods. We clearly demonstrate the feasibility and benefits of using network-based analyses of chemical, genomic and phenotype data to reveal drug-disease associations. The potential associations which were inferred by our method drew the biologists’ attention and provide new perspectives for toxicogenomics and drug reposition evaluation.
Hsu, Chun-Lun, and 許郡倫. "Detecting Differentially Expressed Genes in Heterogeneous Disease Using Half Student t test." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/38709075423432571910.
Повний текст джерела國立臺灣大學
流行病學研究所
97
Gene-expression has been a popular research topic in recent years. Student t-test is commonly adopted to screen disease-related genes. However, when the researches are focused on heterogeneous disease, the means of gene-expression levels between case group and control group may be similar, and thus, the difference would be difficult to be detected by conventional Student t-test. This study proposed half Student t-test to examine heterogeneous disease. Test statistics of half Student t-test only considers sample standard deviation of control group, without considering the sample standard deviation of case group. This study applied Monte Carlo simulation and real gene-expression data of colon cancer to compare the power performance of half Student t-test and conventional Student t-test. Under the simulated scenario, this study found that half Student t-test could have 35% higher statistical power than conventional Student t-test. In addition, after false discovery rate (cut-off point set at 0.05) control of colon cancer gene-expression data, half Student t-test could detect 279 more significant genes than conventional Student t-test. Half Student t-test is easy to execute with good statistical power, and is worth to be recommended as a method of detecting heterogeneous disease gene-expression difference.
Doong, Shyue-Ru, and 董學儒. "Heterogeneous adsorption of infectious bursal disease virus and VP2 subviral particles to immobilized Ni2+ ions." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/51690857603130016951.
Повний текст джерела國立中央大學
化學工程與材料工程研究所
95
The protein VP2, matured from the polyprotein, which was encoded by the genome of infectious bursal disease virus (IBDV), is the primary host-protective immunogen of IBDV. According to VP2-452H subviral particle (SVP) analysis, the determination crystal structure and enzyme-linked immunosorbent assay (ELSIA), showed thar His-tag was not exposed on the surface of VP2-452H SVPs. Thus illustrate that the His-tag apparently did not attribute to the effective purification of this protein by IMAC. An affinity must have existed between the protein VP2 and the immobilized metal ions to achieve SVP binding with Ni-NTA resin. Accordingly, the IBDV generated from DF-1 cell culture and non-tagged VP2-441 SVP generated from a baculovirus-insect cell expression system were purified by IMAC. The purification of IBDV viron through IMAC obtained a 60.5% recovery, and the IMAC-purified IBDV has a similar morphology to the wild-type IBDV with a diameter of 65 nm through electron microscope observation. For SVP formed by VP2-441 purified by IMAC a recovery 92% and a purity of also 92% of mature VP2 were obtained. SVP formed by VP2-441 exhibited a diameter approximately 25 nm. These results obtained from the above experiments can demonstrate 1) the protein VP2 does have interaction with immobilized nickel ion; and 2) the protein VP2 can assist both IBDV viron and SVPs to have the affinity with Ni-NTA resin. The recombinant protein VP2-441, i.e., a structural protein VP2 of infectious bursal disease (IBD) virus, can self-assemble into T=1 subviral particles (SVPs) in baculovirus expression system. These SVPs are not to have multiple his-tags on the surface which result in an efficient purification by immobilized metal-ion affinity chromatography (IMAC). This study aimed at getting more insight into the interaction between VP2-441 SVPs and immobilized metal (Ni2+) ions at molecular level. First of all, large quantity of highly purified VP2-441 SVPs obtained by a one-step purification process allowed the performance of equilibrium adsorption measurements and subsequent determinations of binding constants by fitting two isotherm models, i.e., Temkin and Langmuir-Freundlich. Two general conclusion are obtained, first, the maximum bound VP2-441 SVPs per volume resin is limited because the pore size of IMA gel (ca. 24 nm in diameter) is similar to that of SVPs (20 – 25 nm) and the diffusion of the latter into the pores is hindered. The other is that SVPs have an extremely high affinity to the immobilized Ni+2 ions because the dissociate constants obtained from different models are in the scale of 10-9 M, which suggested the interaction mimicking that between an antigen and its antibody. The high binding strength is derived from a multiple-site binding between VP2-441 SVPs and Ni2+ ions as demonstrated by a concave-up Scatchard plot. Finally, we found that the adsorption of SVPs can be well described by Temkin model. A detail understanding of SVP-immobilized metal ion interactions can provide useful strategies for conducting preparative-scale separations of SVPs or even a real virus using IMAC.
"Consequences of Short Term Mobility Across Heterogeneous Risk Environments: The 2014 West African Ebola Outbreak." Doctoral diss., 2018. http://hdl.handle.net/2286/R.I.49363.
Повний текст джерелаDissertation/Thesis
Doctoral Dissertation Applied Mathematics 2018
Yu, Yue. "Contributions of anisotropic and heterogeneous tissue modulus to apparent trabecular bone mechanical properties." Thesis, 2017. https://doi.org/10.7916/D8FT8Z90.
Повний текст джерела"Understanding the Impact of Social Factors on the Transmission Dynamics of Infectious Diseases Across Highly Heterogeneous Risk Environments." Doctoral diss., 2018. http://hdl.handle.net/2286/R.I.49368.
Повний текст джерелаDissertation/Thesis
Doctoral Dissertation Applied Mathematics for the Life and Social Sciences 2018