Дисертації з теми "Heteroatom Bond"
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Zárate, Sáez Cayetana. "C-heteroatom bond-formation via ni-catalyzed c-o bond cleavage." Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/401555.
Повний текст джерелаA pesar de que el campo del acoplamiento cruzado ha desarrollado increíbles avances, la gran mayoría de procesos todavía se basa en el uso de halogenuros de arilo. Sin embargo, este tipo de electrófilos presentan una toxicidad intrínseca y, a su vez, su síntesis resulta tediosa, especialmente cuando se trata de halogenuros de arilo altamente funcionalizados. Debido a ello, la comunidad sintética se ha volcado en la búsqueda de alternativas al uso de halogenuros de arilo en química de acoplamiento cruzado. Un gran esfuerzo se ha desarrollado en la última década para implementar los derivados del fenol en este tipo de transformacions debido a la abundancia natural y comercial de dichos compuestos y a su baja toxicidad en comparación con los organohalogenuros. Sin embargo, la alta energía de activación necesaría para romper los enlaces C-O ha limitado considerablemenete el uso de derivados del fenol en reacciones de acomplamineto cruzado, sobre todo si se trata de éteres de metilo. Actualmente la gran mayoría de métodos basados en esta familia de electrófilos se utilizan en la formación de enlaces C-C. De lo contrario, apenas existen técnicas para obtener enlaces C-heteroátomo probablemente debido a la baja reactividad de los nucleófilos donde la densidad de carga negativa reside en un heteroátomo. La presente tesis docotoral se ha centrado en el desarrollo de nuevas metodologías para la creación de enlaces de tipo C-heteroatomo mediante la activción catalítica de enlaces C-O con complejos de Ni. Se han descrito novedosos métodos de sililación y borilación de ésteres y metil éteres de arilo y bencilo. Dichos métodos suponen una via alternativa para la síntesis de silanos y boronatos, los cuales son intermedios de gran utilidad en síntesis orgánica. Además, el descubrimiento de unas condiciones totalmente inusuales para activar enlaces de tipo C-OMe ha abierto nuevas perspectivas sobre la reactividad de este tipo de enlaces y, a la vez, ha sugerido la existencia de nuevos mecanismos de activación.
While the field of cross-coupling has reached remarkable levels of sophistication, the vast majority of processes are still being conducted with organic halide counterparts. Drawbacks associated to their toxicity and the limited accessibility of densely functionalized aryl halides have prompted chemists to develop powerful, yet practical, alternatives. Among these, the utilization of phenol derivatives as coupling partners via C-O bond cleavage would be particularly rewarding due to their readily availability and benign nature. However, the high activation energy required for effecting C–O bond cleavage has become a daunting challenge when devising catalytic techniques using phenol derivatives, specially always-elusive aryl methyl ethers. At present, the vast majority of cross-coupling reactions using phenol derivatives remains confined to C–C bond formation, whereas the formation of C-heteroatom bonds has been poorly studied, likely due to the less reactivity of heteroatom-based nucleophiles. This doctoral thesis has focused on the development of new methodologies for forging C-heteroatom bonds via Ni-catalyzed C-O bond cleavage. It has been described new protocols for the silylation and borylation of aryl and benzyl esters and methyl ethers. These methodologies can be used as useful alternatives towards the synthesis of aryl and benzyl silanes and boronates, incredible important intermediates in organic synthesis. Furthermore, the discovery of unusual, yet surprising, conditions for the cleavage of C-OMe bonds have opened up new vistas towards the reactivity of aryl and benzyl methyls ethers while suggesting new activation pathways.
van, Rooy Sara Emily. "Reactivity of rhodium-heteroatom bonds: from catalytic bond activation to new strategies for olefin functionalization." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/444.
Повний текст джерелаNiljianskul, Nootaree. "New Pd and Cu-based catalysts for carbon-heteroatom bond formation." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98784.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references.
The research presented in this dissertation is aimed at the development of novel methodologies for carbon-heteroatom cross-coupling reactions catalyzed by late-transition metals. Both palladium and copper are central to the field of transition metal-catalysis and are integral to the catalyst systems developed as part of our continual advancement in cross-coupling reactions. The first part of this thesis focuses on the use of palladium catalysts to form carbon-sulfur bonds directed towards aryl sulfonamide synthesis. The second part of the thesis describes the recent development in the copper(!) hydride mediated formation of carbon-nitrogen bonds via hydroamination of olefins. Part I. Chapter 1. Palladium-Catalyzed Chlorosulfonylation of Arylboronic Acids Using a biaryl phosphine ligand platform, the first palladium-catalyzed cross-coupling reaction of phenyl chlorosulfate with arylboronic acids was achieved. In this context, the arylsulfonyl chloride products serve as useful precursors to a variety of sulfonyl functional groups, such as aryl sulfonamides, aryl sulfones, and arenesulfonate esters. In particular, this method allows for the preparation of a number of arylsulfonyl chlorides that are not accessible via electrophilic aromatic substitution pathways and under mild reaction conditions. Additionally, this methodology points to an unprecedented selectivity for the phenylchlorosulfate electrophiles used in the cross-coupling reactions. Part II. Chapter 2. Enantio- and Regioselective Copper-Catalyzed Hydroamination of Styrenes and the Extension of the Methodology towards Anti-Markovnikov Hydroamination of Terminal Aliphatic Alkenes The development of a copper-mediated strategy towards the hydroamination of styrene derivatives is reported. In this system, the reaction proceeds regioselectively and enantioselectively to generate [alpha]-branched amines. The system can transform a wide variety of substituted styrenes, including trans-, cis-, and [beta]-disubstituted styrenes. In addition, our extension to copper-catalyzed hydroamination reactions of unactivated aliphatic olefins is reported. Using terminal aliphatic alkenes, the copper-catalyzed hydroamination reactions proceed with anti-Markovnikov regioselectivity. Preliminary results point to the application of this methodology towards [beta]-chiral amine synthesis via the hydroamination of I, 1-disubstituted alkenes. Chapter 3. [alpha]-Aminosilane Synthesis via Copper-Catalyzed Hydroamination of Vinylsilanes The copper-catalyzed hydroamination of vinylsilanes is described. This regioselective reaction generates a-chiral aminosilanes in high yields and enantioselectivities. The method is compatible with differentially substituted vinylsilanes and allows access to many valuable chiral organosilicon compounds. Chapter 4. Synthesis of [gamma]-Chiral Amines via Copper-Catalyzed Hydroamination of 3,3- Disubstituted Allylic Alcohols and 3,3-Disubstituted Allylic Benzoates An investigation into the copper-catalyzed hydroamination of allylic alcohols and allylic benzoates is reported. The reaction proceeds via a [beta]-alkoxy elimination, setting a stereogenic center at the 3-postion to generate [gamma]-chiral amine products. The reaction is more efficient using allylic benzoates. This method is completely regioselective and is applicable to aliphatic allylic benzoates as well as aromatic allylic benzoates. Additionally, we demonstrated that this strategy is applicable towards an allylic epoxide substrate to generate [delta]-chiral amine.
by Nootaree Niljianskul.
Ph. D. in Organic Chemistry
Ly, Tuan Q. "New heteroatom ligands and metalla-heterocycles via P-N bond formation." Thesis, Loughborough University, 1997. https://dspace.lboro.ac.uk/2134/32271.
Повний текст джерелаOliver, Thomas Albert Anthony. "Exploring photoinduced heteroatom-H bond fission in the gas and solution phases." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.541647.
Повний текст джерелаDe, Fusco Claudia. "Stereoselective carbon-carbon and carbon-heteroatom bond formation mediated by bifunctional organocatalysts." Doctoral thesis, Universita degli studi di Salerno, 2013. http://hdl.handle.net/10556/1323.
Повний текст джерелаThis PhD work describes the development of different Michael and Michael type processes employing different bifunctional organocatalysts. All the processes studied involved a non-covalent activation of the substrates provided by the organic promoters. An asymmetric epoxidation of electron-poor trisubstituted olefins has been developed by employing the commercially available diphenyl prolinol which afforded the epoxides in high yield, complete diastereocontrol and good enantioselectivity. Diaryl prolinols were found to promote a Michael addition of -ketoesters to nitroalkenes. An unexpected high efficiency and stereocontrol was observed with hexafluorobenzene as unconventional solvent, but also employed as an additive. A convenient tandem double Michael addition process was developed to access symmetrically and unsymmetrically 3,5-diaryl substituted cyclohexanones by using quinine as catalyst. An aziridination reaction of terminal electron-poor olefins has been disclosed by using a commercially available aminothiourea catalyst. The desired aziridines, bearing a quaternary stereocenter, were isolated in good yield and enantiocontrol. These compounds, were regioselectively ring-opened to access valuable ,-disubstituted -amino ester derivatives. Finally an asymmetric Fischer indolization to produce helical molecules was investigated employing a chiral phosphoric acid as promoter and an ion-exchange polymer as ammonia scavenger. [edited by author]
XI n.s.
Maluenda, Borderas Irene. "(N-heterocyclic carbene) : metal catalysed carbon-carbon and carbon-heteroatom bond-forming reactions." Thesis, University of Sussex, 2018. http://sro.sussex.ac.uk/id/eprint/76274/.
Повний текст джерелаTsang, Melanie Wing-Sze. "Pd-catalysed carbon-heteroatom bond formation and urea synthesis in supercritical carbon dioxide." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614105.
Повний текст джерелаCasitas, Montero Alícia. "Reactivity of well-defined organometallic copper(III) complexes in carbon-heteroatom bond forming reactions." Doctoral thesis, Universitat de Girona, 2012. http://hdl.handle.net/10803/81985.
Повний текст джерелаAquesta tesi es centra en el camp de la química organometàl•lica del coure(III) que roman sense explorar. Els complexos arilcoure(III) s'han proposat com a intermedis clau en les reaccions de condensació Ullmann que consisteixen en l'acoblament d'halurs d'arils i nucleòfils basats en heteroàtoms catalitzades amb coure. L'estudi de la reactivitat de complexos arilcoure(III) ben definits pot proporcionar una millor comprensió del mecanisme de les reaccions de condensació Ullmann, el qual es troba sota un intens debat. En aquesta tesi doctoral s'estudia la viabilitat del complexos arilcoure(III), estabilitzats en lligands macrocíclics, de participar en reaccions de formació d'enllaç carboni-heteroàtom. S'han desenvolupat reaccions de formació d'enllaç C-N i C-O així com reaccions d'intercanvi d'halurs, on s'inclouen fluoracions, catalitzades amb coure i basades en un cicle catalític Cu(I)/Cu(III) utilitzant substrats models d'halur d'aril. S'ha obtingut una comprensió fonamental de les etapes redox a dos electrons, addició oxidant i eliminació reductiva, en coure.
Reding, Matthew Todd. "The development and synthetic application of titanium-mediated carbon-heteroatom double bond hydrosilylation methodologies." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/42643.
Повний текст джерелаAltman, Ryan A. (Ryan Alan). "Recent advances in copper- and palladium-catalyzed carbon-heteroatom and carbon-carbon bond-formation." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/43779.
Повний текст джерелаVita.
Includes bibliographical references.
Metal-catalyzed nucleophilic substitution reactions of aryl halides have become one of the most valuable and useful classes of reactions developed in the last 30 years. Foremost among these processes are the classes of palladium- and copper-catalyzed reactions, which employ heteroatom-based nucleophiles. Herein, newly designed catalyst systems are presented for the palladium- and/or copper-catalyzed nucleophilic substitution reactions of aryl halides with a variety of nucleophiles, including (benz)imidazoles, oxindoles, 2-, 3- and 4-hydroxypyridines, anilines, and aliphatic, benzylic, allylic and propargylic alcohols. In many cases, catalyst optimization and ligand structure are discussed and evaluated. Where applicable, the palladiumand copper-based catalyst systems are contrasted to demonstrate the complementary relationships between the employment of these two metals. Chapter One Chapter Two Chapter Three Chapter Four Chapter Five. Palladium- and Copper-catalyzed Reactions of Imidazoles and Benzimidazoles with Aryl Halides. Orthogonal Selectivity in Copper- and Palladium-catalyzed Reactions of Aryl Halides with Oxindoles. Copper-catalyzed Reactions of Hydroxypyridines and Related Compounds with Aryl Halides. Pyrrole-2-carboxylic Acid as a Ligand for the Copper-catalyzed Reactions of Primary Anilines with Aryl Halides. An Improved Copper-based Catalyst System for the Reactions of Aryl Halides with Aliphatic Alcohols.
y Ryan A. Altman.
Ph.D.
Ichikawa, Saki. "Copper-catalyzed carbon-heteroatom bond formations : asymmetric hydroamination and continuous-flow aromatic Finkelstein reaction." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122852.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references.
The studies presented in this dissertation are regarding the development of new methods for copper-catalyzed carbon-heteroatom bond formations, including asymmetric hydroamination and continuous-flow aromatic Finkelstein reaction. The first part of this dissertation focuses on the development of copper-catalyzed asymmetric hydroamination reactions to access various classes of enantioenriched amines. This includes the development of a broadly applicable hydroamination protocol for the synthesis of enantioenriched N-arylamines (Chapter 1) and 1,2- diamines (Chapter 2). The second part of this dissertation describes the development of copper-catalyzed aromatic Finkelstein reaction under continuous-flow conditions (Chapter 3). Part I. Chapter 1.
A Modified System for the Synthesis of Enantioenriched N-Arylamines through Copper-Catalyzed Hydroamination Despite significant recent progress in copper-catalyzed enantioselective hydroamination chemistry, the synthesis of chiral N-arylamines, which are frequently found in natural products and pharmaceuticals, has not been realized. Initial experiments with N-arylhydroxylamine ester electrophiles were unsuccessful and instead, their reduction, in the presence of copper hydride (CuH) catalysts, was observed. We detail key modifications of our previously reported hydroamination protocols that led to broadly applicable conditions for the enantioselective net addition of secondary anilines across the double bond of styrenes, 1,1 -disubstituted alkenes, and terminal alkenes. NMR studies suggest that suppression of the undesired reduction pathway is the basis for the dramatic improvements in yield under this new protocol. Chapter 2.
Regio- and Enantioselective Synthesis of 1,2-Diamine Derivatives by Copper- Catalyzed Hydroamination A highly regio- and enantioselective synthesis of 1,2-diamines using [gamma]-substituted allylic pivalamides via copper-catalyzed hydroamination is reported. The N-pivaloyl group is essential, both in facilitating the hydrocupration step and in suppressing the unproductive [beta]-elimination from the alkylcopper intermediate. This synthetic approach enables an efficient construction of chiral, differentially protected, vicinal diamines under mild conditions with broad functional group tolerance. Part II. Chapter 3. Rapid and Efficient Copper-Catalyzed Finkelstein Reaction of (Hetero)Aromatics under Continuous-Flow Conditions A general, rapid, and efficient method for the copper-catalyzed Finkelstein reaction of (hetero)aromatics has been developed using continuous flow to generate a variety of aryl iodides.
The described method can tolerate a broad range of functional groups, including N-H and O-H groups. Additionally, in lieu of isolation, the aryl iodide products in solution can be directly used in two distinct multistep continuous-flow processes (amidation or Mg-I exchange/nucleophilic addition) to demonstrate the flexibility of this method.
by Saki Ichikawa.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Chemistry
Gu, Yiting. "C-H & C-O Functionalization by Silicon-Heteroatom Interelement Linkage." Doctoral thesis, Universitat Rovira i Virgili, 2019. http://hdl.handle.net/10803/668961.
Повний текст джерелаLa química sintética es casi inimaginable sin tres elementos principales del grupo, a saber, boro, silicio y estaño. Cuando se unen a un átomo de carbono de cualquier hibridación, estos grupos funcionales sirven como linchpins excepcionalmente versátiles en síntesis, transformándose selectivamente en una enorme variedad de enlaces C-C y C-X, por lo tanto, descubren nuevos métodos para forjar el valor agregado C-Si, Los bonos C-B y C-Sn siempre tienen una gran demanda. En línea con el interés de la investigación en el grupo de Martín de la activación de enlaces o moléculas inertes, esta tesis doctoral se centra en el desarrollo de nuevas técnicas para hacer uso del enlace de interelemento de silicio-heteroátomo para funcionalizar el enlace inerte C-O & C-H a través de catálisis de níquel o sistema sin transición de metal. Hemos desarrollado tres nuevos métodos para la funcionalización de enlaces inertes C-O y C-H mediante el uso de enlaces de interelemento basados en silicio. Todas las transformaciones anteriores muestran un excelente perfil de quimioselectividad en condiciones suaves. Se realizan estudios y debates mecanicistas preliminares para comprender cómo y por qué se produjeron estas reacciones. Las transformaciones realizadas contribuyen a la comprensión del uso más prolífico de enlaces químicos inertes a los compuestos de valor agregado de síntesis.
Synthetic chemistry is almost unimaginable without three main group elements, namely, boron, silicon, and tin. When attached to a carbon atom of any hybridization, these functional groups serve as exceptionally versatile linchpins in synthesis, selectively transforming into an enormous breadth of C-C and C-X bonds, thus, discover new methods to forge value added C-Si, C-B and C-Sn bonds are always in highly demand. In line with the research interest in Martín’s group of activating inert bonds or molecules, this doctoral thesis focuses on the development of novel techniques to make use of silicon-heteroatom interelement linkage to functionalize inert C-O & C-H bond via either nickel catalysis or transition metal free system. We have developed three new methods towards the functionalization of inert C-O & C-H bonds by using silicon-based interelement linkages. All the above transformations display excellent chemoselectivity profile under mild conditions. Preliminary mechanistic studies and discusses are carried out to understand how and why these reactions proceeded. The transformations realized contribute to the understanding of more prolific use of inert chemical bonds to the synthesis value added compounds. We believe these protocols would definitely contribute to a systematic utilization of silicon-heteroatom reagent in the arena of inert chemical bond functionalization.
Cazin, Catherine Suzanne Julienne. "Catalysis of carbon-carbon and carbon-heteroatom bond-forming reactions : the importance of the palladium source." Thesis, University of Exeter, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248165.
Повний текст джерелаGraßl, Simon [Verfasser], and Paul [Akademischer Betreuer] Knochel. "Elaboration of electrophilic carbon heteroatom bond forming reactions using organozinc reagents / Simon Graßl ; Betreuer: Paul Knochel." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1210424398/34.
Повний текст джерелаEkoue-Kovi, Kekeli Adjoa Sika. "Palladium-phosphinous acid-catalyzed carbon-carbon and carbon-heteroatom bond formation and synthesis of new antimalarial drugs." Connect to Electronic Thesis (CONTENTdm), 2008. http://worldcat.org/oclc/458487914/viewonline.
Повний текст джерелаPROPERZI, ROBERTA. "Synthesis of Pharmaceutically Active Heterocycles and Lipid Targets: Novel Rearrangements and Methods for Carbon-Heteroatom Bond Formation." Doctoral thesis, Università degli Studi di Camerino, 2014. http://hdl.handle.net/11581/401829.
Повний текст джерела朱煒章 and Wai-cheung Chu. "Syntheses and reactions of copper and manganese complexes of tetradentate polyanionic chelating ligands and their applications incarbon-heteroatom bond formation reactions." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31236789.
Повний текст джерелаChu, Wai-cheung. "Syntheses and reactions of copper and manganese complexes of tetradentate polyanionic chelating ligands and their applications in carbon-heteroatom bond formation reactions /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19324893.
Повний текст джерелаBruneau, Alexandre. "Développement de nouvelles réactions métallo-catalysées pour la création de liaisons C-C et C-hétéroatomes : Application à la synthèse d’inhibiteurs de la Hsp90 et aux ligands de la lectine A." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS138.
Повний текст джерелаThe work reported in this dissertation concerns the development of new metal-catalyzed reactions for the creation of carbon-heteroatom and carbon-carbon bonds as well as their applications to the synthesis of biologically active products.The first part of this manuscript is devoted to the study of the reactivity of sugars as nucleophiles in organometallic couplings. Conditions were developed for the creation of the C-S bond between glycosyl thiols and aryl partners. Moreover, the creation of the nitrogen carbon bond of glycosyl amine with boronic acids was studied. The products synthesized in this first part have been evaluated for their potential to inhibit the lectin A, in Pseudomonas aeruginosa related lung infections.The second part of this work is dedicated to the creation of a new series of 6BrCaQ analogues as Hsp90 inhibitors and their biological evaluation. This new series was synthetized through a new CH activation methodology. The antitumoral potential was evaluated and will be presented in this manuscript
Buquoi, John Q. III. "Multicomponent Radical Reactions Incorporating Heteroatom-Carbon Bonds Via Polarity-Reversal Cascades." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574348050305556.
Повний текст джерелаHoppe, Martin Louis. "Characterization of the electronic structure of complexes containing metal-heteroatom multiple bonds." Diss., The University of Arizona, 1988. http://hdl.handle.net/10150/184616.
Повний текст джерелаReina, Tapia Antonio. "Metal nanoparticles stabilized by alkaloids in glycerol : from design to catalytic applications." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30160.
Повний текст джерелаMetal nanoparticles (MNPs) have been largely studied in the last decades due to their interesting properties which found applications in several fields (microelectronics, materials and catalysis, among others). In contrast to common organic solvents, ionic liquids, water, supercritical CO2, polyols such as glycerol, represent innovative solvents for the immobilization of MNPs, avoiding their agglomeration and facilitating their recycling. Small, spherical, and well-dispersed Pd(0) and Ni(0) nanoparticles were synthesized under hydrogen pressure in glycerol, in the presence of different kinds of stabilizers (cinchona-based alkaloids, phosphine, polymer). The high stability of these colloidal solutions permitted the full characterization both in solution and at solid state, large-scale synthesis, and stocking the solutions for months. These colloidal catalysts were applied in a large variety of transformations including hydrogenations, hydrodehalogenations, Hiyama C-C couplings, hydrosilylation reactions, and Michael conjugate additions. Furthermore, we conducted a comparative study exhibiting the differences in catalytic reactivity by effect of the stabilizer, allowing us tuning the surface-state of the nanoparticles. Moreover, we showed the ability of glycerol to immobilize metal nanoparticles permitting the recycle of the catalytic phase between 4 and 10 times, without metal leaching. Additionally, we studied the behavior of ligand-free Ni(OAc)2 in glycerol as an alternative catalyst for C-C and C-heteroatom couplings. Also, we developped a continuous flow study, in collaboration with the Maison Européenne des Procédés Innovants (MEPI), for the hydrogenation of different functional groups, using PdNPs in glycerol
Zani, Lorenzo. "Studies on the zinc mediated phenyl and alkynyl addition to carbon heteroatom double bonds." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980571707.
Повний текст джерелаKunchithapatham, Kamala. "Development of Calcium and Palladium Catalysts for the Formation of Carbon-Carbon and Carbon-Heteroatom Bonds." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337955731.
Повний текст джерелаZAGHI, ANNA. "Batch and continuous-flow synthetic processes for the formation of carbon-carbon and carbon-heteroatom bonds." Doctoral thesis, Università degli studi di Ferrara, 2017. http://hdl.handle.net/11392/2488074.
Повний текст джерелаOrganocatalyzed reactions in which organic molecules catalyze single or multiple chemical transformations were found to be an efficient synthetic tool for creating various carbon-carbon and carbon-heteroatom bonds throughout the synthesis of a wide range of achiral and chiral acyclic as well as cyclic derivatives. The benefits of organocatalytic reactions include the use of inexpensive and readily available organic compounds as catalysts, as well as increased synthetic efficiency as no metal traces have to be removed at the end of the processes. This last feature is particularly suited to the preparation of biologically relevant compounds that do not tolerate contamination. The continuous-flow approach has recently emerged in the organic chemistry community as an interesting and alternative method to batch processing for performing chemical transformations. This technology has a number of attractive advantages that are related both to the nature of the continuous process and to the small size of the channels in which the reactions occur. These include (i) large surface to volume ratios and enhanced mixing quality; (ii) superior mass and heat transfer and, hence, improved operational safety; (iii) good real-time reaction monitoring by incorporating in-line analytical devices, allowing fast reaction screening and optimization; (iv) improved scalability. Typical drawbacks of organocatalysis such as organocatalyst recycling and the high catalyst loading often required for several transformations may be overcome by the heterogeneization of organocatalysts that allows the set-up of effective continuous-flow procedures endowed with high levels of stereoselectivity and productivity. The majority of the reported studies on asymmetric flow organocatalysis utilize the active catalyst immobilized on either polymeric or inorganic particles as packing material of macro- and micro-reactors. In this thesis are reported batch and continuous-flow synthetic approaches for the formation of carbon-carbon and carbon-heteroatom bonds, mediated by organocatalysts acting via enamine and iminium catalysis, and umpolung reactivity.
Platon, Mélanie. "Propriétés et performances de phosphines ferrocéniques dans le couplage C-O, C-S et C-N : nouvelles méthodologies de synthèse au palladium." Phd thesis, Université de Bourgogne, 2012. http://tel.archives-ouvertes.fr/tel-00818998.
Повний текст джерелаKyne, Robert E. "Strategic Applications of Pinacolato Allylboron Reagents: New Reactions in Enantioselective Allyl-Allyl Cross-Coupling and Allylboration to Form New Carbon-Heteroatom Bonds." Thesis, Boston College, 2012. http://hdl.handle.net/2345/3163.
Повний текст джерелаDetailed within this dissertation are three new reactions involving allylboron reagents. Chapter 1 describes the development of Pd-catalyzed allyl-allyl cross-coupling for the preparation of enantioenriched all-carbon quaternary stereogenic centers. This methodology represents a novel approach to a significant challenge for synthetic chemists. Subsequently, an allyl-allyl cross-coupling is described which generates functionally differentiated 1,5-dienes. Such structures allow for several chemoselective manipulations, which add a significant practical note to this cross-coupling methodology. Chapter 2 details the development of the allylboration of nitrosobenzene with (Z)-crotylboronate derivatives, which results in the formation of branched allylic alcohols. This methodology provides a regioselective complement to standard boron oxidation conditions
Thesis (PhD) — Boston College, 2012
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Chemistry
Hossain, Asik [Verfasser], Oliver [Akademischer Betreuer] Reiser, Burkhard [Akademischer Betreuer] Koenig, and Arno [Akademischer Betreuer] Pfitzner. "Catalytic Construction of Carbon-Heteroatom Bonds by Shining Visible-Light on Transition-Metal Photocatalysts / Asik Hossain ; Oliver Reiser, Burkhard Koenig, Arno Pfitzner." Regensburg : Universitätsbibliothek Regensburg, 2021. http://d-nb.info/1225121388/34.
Повний текст джерелаMajek, Michal [Verfasser], von Wangelin Axel [Akademischer Betreuer] Jacobi, Burkhard [Akademischer Betreuer] König, Frank-Michael [Akademischer Betreuer] Matysik, and Mancheño Olga [Akademischer Betreuer] García. "Activation of arene-heteroatom bonds by photoredox catalysis with visible light / Michal Majek ; Axel Jacobi von Wangelin, Burkhard König, Frank-Michael Matysik, Olga García Mancheño." Regensburg : Universitätsbibliothek Regensburg, 2016. http://d-nb.info/1120117488/34.
Повний текст джерелаTseng, Nai-Wen. "Transition Metal-catalyzed Carbon-carbon/Carbon-heteroatom Bond Formation Reactions Utilizing Strained Ring Systems." Thesis, 2009. http://hdl.handle.net/1807/19101.
Повний текст джерелаTsui, Chit. "New Synthetic Applications of Rhodium-Catalyzed Carbon-Carbon and Carbon-Heteroatom Bond Forming Reactions." Thesis, 2013. http://hdl.handle.net/1807/36019.
Повний текст джерелаBERRINO, ROBERTA. "Studies on the transition metal-catalyzed C-C and C-heteroatom bond forming reactions." Doctoral thesis, 2012. http://hdl.handle.net/11573/918824.
Повний текст джерелаNewman, Stephen. "Reversible Oxidative Addition in Palladium Catalysis: New Methods for Carbon–Carbon and Carbon–Heteroatom Bond Formation." Thesis, 2012. http://hdl.handle.net/1807/34824.
Повний текст джерелаDhineshkumar, J. "Iodine and Copper Catalyzed Oxidative Cross Coupling Reactions : Design and Development of Carbon-Carbon and Carbon-Heteroatom Bond Forming Reactions." Thesis, 2016. http://hdl.handle.net/2005/3020.
Повний текст джерелаRokade, Balaji Vasantrao. "Copper-Catalyzed Novel Oxidative Transformations : Construction of Carbon-Hetero Bonds." Thesis, 2014. http://etd.iisc.ernet.in/2005/3479.
Повний текст джерелаDubland, Joshua. "Studies towards Developing Diastereoselective SN1 Reactions of α-Keto Carbocations". Thesis, 2010. http://hdl.handle.net/1807/24246.
Повний текст джерелаIAZZETTI, ANTONIA. "Transition Metals Catalysis in C-C and C-Heteroatom Bonds Forming Reactions." Doctoral thesis, 2013. http://hdl.handle.net/11573/917801.
Повний текст джерелаGujadhur, Rattan K. "The formation of aryl -carbon and aryl -heteroatom bonds using copper(I) catalysts." 2003. https://scholarworks.umass.edu/dissertations/AAI3110494.
Повний текст джерелаZani, Lorenzo [Verfasser]. "Studies on the zinc mediated phenyl and alkynyl addition to carbon heteroatom double bonds / vorgelegt von Lorenzo Zani." 2006. http://d-nb.info/980571707/34.
Повний текст джерелаFeng, Yuee. "Synthesis and reactivity of ruthenium and platinum complexes with non-dative heteroatomic ligands studies of carbon-hydrogen bond activation /." 2007. http://www.lib.ncsu.edu/theses/available/etd-12132007-121728/unrestricted/etd.pdf.
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