Дисертації з теми "Hepatitis G virus Victoria"
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Halasz, Robert. "Epidemiology and clinical importance of GB virus C/hepatitis G virus /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-3997-7/.
Повний текст джерелаCuceanu, Narcisa Manuela. "Structural and genetic analysis of hepatitis G virus/GB virus-C." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/22126.
Повний текст джерелаSentjens, Roel Emiel Johannus Henricus. "New developments in hepatitis B, C and G virus." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/87188.
Повний текст джерелаBerg, Thomas. "Chronische Hepatitis C." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2002. http://dx.doi.org/10.18452/13812.
Повний текст джерелаThe major goal of this thesis is the analysis of the clinical outcome of patients with Hepatitis C virus (HCV) infection and the response to therapy. Analysed were 1. different types of therapeutic strategies 2. causes responsible for ineffective antiviral therapy (non-response) 3. clinical relevance of the newly discovered hepatitis-associated viruses and 4. the role of these viruses in patients with acute or chronic hepatitis of unknown causes and in those receiving liver grafts. Ad 1. Compared were different therapeutic concepts such as short-term combination therapy, triple-therapy, high dose IFN?-therapy and the use of antiviral substances such as ribavirin and amantadine. It emerged that relevant prognostic parameters can be deduced with respect to the therapeutic response rate. Ad 2. Analysed were possible molecular mechanisms, which may interfere with response or non-response to antiviral therapy. In this respect, we focussed on the interaction of certain HCV-proteins as NS5A, E2, so-called PKR-eIF2a phosphorylisation-homology-domain (PePHD). with the interferon-?-induced effector proteins. There is evidence, that number of mutations within the NS5A proteins are of prognostic relevance with respect to the response to interferon?-therapy. In contrast, mutations within the PePHD-region do not play any role in this respect. Ad 3. We also studied the clinical relevance of the newly discovered viruses GBV-C/HGV and TTV, and found, that they have no impact concerning the course of chronic hepatitis C. These viruses are interferon-sensitive and do not influence the IFNa-response as it could be documented by following the course of co-infected patients. Ad 4. Our studies also focused on the prevalence, transmission and relevance of GBV-C/HGV and TTV infections with respect to their role as hepatitis-inducing agents. We can show that both virus types are parenterally transmitted. There is a high prevalence for both types in patients confronted with risk factors for parenteral factors. From analysis of many patients being chronically infected with these viruses it became quite clear that they lack any important potency to provoke chronic liver disease.
Tucker, Timothy Johan Paul. "Epidemiology, molecular characterisation and tropism of the Hepatitis G Virus / GBV-C." Doctoral thesis, University of Cape Town, 1999. http://hdl.handle.net/11427/25669.
Повний текст джерелаISHIKAWA, TETSUYA. "IMMUNOREGULATION OF HEPATITIS B VIRUS INFECTION : RATIONALE AND CLINICAL APPLICATION." Nagoya University School of Medicine, 2012. http://hdl.handle.net/2237/16732.
Повний текст джерелаLarios, Paterna Cristina. "Péptidos de fusión del virus de la hepatitis G: definición, síntesis y caracterización biofísica." Doctoral thesis, Universitat de Barcelona, 2006. http://hdl.handle.net/10803/1806.
Повний текст джерелаdescritos hasta el momento, se encuentran en la zona interna de la proteína estructural.
El virus de la hepatitis G se asemeja estructuralmente al virus de la hepatitis C, por ello,la búsqueda del péptido de fusión se centró en la proteína estructural E2 también presente en el virus de la hepatitis C. Las regiones escogidas dentro de la proteína estructural pertenecen a la región amino terminal, E2(7-26), y la zona interna (E2(279-298).
Estas secuencias fueron sintetizadas mediante metodología en fase sólida y se estudió la
interacción entre los péptidos y modelos de membrana de distinta complejidad (monocapas lipídicas, bicapas lipídicas). Las técnicas utilizadas para conocer la interacción entre ambos fueron las isotermas de Langmuir, la calorimetría diferencial de barrido, la espectroscopia de fluorescencia, la espectroscopia de UV y la microscopía.
Además se estudió la conformación adoptada por los péptidos por las técnicas de dicroísmo circular y espectroscopia de infrarrojos por transformada de Fourier. De todos los resultados obtenidos el péptido que interaccionó en mayor medida con los modelos de membrana, además de desestabilizar y producir fusión fue E2(279-298). Este péptido producía un cambio en su conformación al interaccionar con membranas fosfolipídicas(sobre todo en presencia de cargas negativas) hacia una estructura de tipo alfa-hélice. Este cambio hacia una estructura más ordenada podría proporcionar la conformación activa del péptido responsable de la desestabilización de las membranas.
The hepatitis G virus (GBV-C/HGV) is a enveloped RNA virus belonging to the "Flaviviridae" family. The natural history of the GBV-C/HGV infection is at present not fully understood and its potential to cause hepatitis in humans is questionable.
Elucidation of the mechanism of the fusion of enveloped viruses to target membranes has attracted considerable attention because of its relative simplicity and potential clinical importance. Apart from the functions of viral binding to target membranes and the activation of viral fusion proteins, usually only one viral protein is responsible for the membrane fusion step. However, the nature of the interaction of viral fusion proteins with membranes and the mechanism by which these proteins accelerate the formation of membrane fusion intermediates are poorly understood. In this sense, specialized
hydrophobic conserved domains ("fusion peptides") have been postulated to be absolutely required for the fusogenic activity.
The main objective of the present work was the knowlegment of the fusion peptide of the hepatitis G virus. For this purpose we have performed studies with different synthetic peptides belonging the envelope protein E2 of hepatitis G virus. The selected peptides were from the amino terminal part of the protein (E2(7-26)) and from the internal part (E2(279-298)). We have analysed lipid-peptide interactions depending on the degree of complexity of model membranes: monolayer studies (surface activity,
insertion of peptides into monolayers) and liposomes studies (differential scanning
calorimetry, fluorescence measurements). The peptides were compared for their ability
to interact and perturb membranes. In addition, they were also tested for their ability to
induce both leakage of vesicular contents and vesicle fusion as well as to lyse erythrocytes. Furthermore, we have studied the conformational behaviour of the peptides in water and in different membrane environments by Fourier-transform infrared spectroscopy (FTIR) and circular dichroism (CD). The results obtained showed that the E2(279-298) sequence was able to interact, penetrate and permeabilize vesicles
bilayers in a higher extent than E2(7-26) sequence. Furthermore, the interaction with
membranes induced a change in the internal peptide to an alpha-helical conformation while
the amino terminal sequence did not. This indicate that this internal segment peptide
could be involved in the fusion of hepatitis G virus into cell membrane.
Alay, Romero Maria Teresa. "Estudis fisicoquímics de diferents seqüències peptídiques del virus de l’Hepatitis G." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/285310.
Повний текст джерелаLai, Agnes Suet Wah. "Hepatitis C and G virus infection and non-Hodgkin lymphoma in a case-control study from British Columbia, Canada." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31732.
Повний текст джерелаMedicine, Faculty of
Graduate
Pérez, Escoda María Teresa. "Diseño y síntesis de péptidos para el diagnóstico de la infección por el virus de la hepatitis G (GBV-C/HGV)." Doctoral thesis, Universitat de Barcelona, 2007. http://hdl.handle.net/10803/1807.
Повний текст джерелаDesde hace años, los péptidos sintéticos se vienen utilizando en sistemas de diagnóstico para muchas enfermedades, sin embargo, los péptidos lineales que mimetizan epítopos B son débilmente reconocidos por los anticuerpos, y por ello, existe la tendencia de utilizar combinaciones más complejas que permitan mejorar tanto la sensibilidad como la especificidad de los ensayos.
En esta tesis se han diseñado y sintetizado, utilizando la metodología de síntesis en fase sólida, construcciones peptídicas en las que se combinan regiones de proteínas de envoltura y no estructurales. Se han sintetizado tanto péptidos quiméricos, que contienen más de un epítopo (lineales y ramificados), como péptidos cíclicos en los que los epítopos sufren restricción de movilidad.
La capacidad antigénica de las construcciones sintéticas se ha evaluado utilizando principalmente la técnica del enzimoinmunoensayo (ELISA) aunque también se ha investigado la utilidad de la técnica de la resonancia del plasmón de superficie (SPR) para detectar la presencia de anticuerpos anti-GBV-C/HGV en muestras de suero de individuos pertenecientes tanto a los grupos de riesgo como en la población sana. Además, se ha realizado un estudio conformacional con la finalidad de establecer una correlación entre la estructura secundaria adoptada por los péptidos y su capacidad antigénica. Finalmente, se ha estudiado la capacidad inmunogénica de las construcciones peptídicas en animales de experimentación.
Los resultados obtenidos muestran, por un lado, que las construcciones en las que se combinan varios epítopos son las que presentan una mejor precisión diagnóstica, y por otro lado, que la introducción de restricción de movilidad permite incrementar la sensibilidad mostrada por la molécula precursora lineal.
"Design and synthesis of peptides for serodiagnose of the hepatitis G virus (GBV-C/HGV) infection".
The GB virus C, so called hepatitis G virus (GBV-C/HGV), is a single-strand RNA virus belonging to the Flaviviridae family. The prevalence rate of GBV-C/HGV in healthy blood donors is 1-4% in worldwide and about 20-35% in high risk populations, thus indicating that this virus is transmitted via the parenteral route. Although controversial data exit concerning the potential to cause hepatitis in humans recent studies suggest that coinfection with HIV is associated with prolonged survival. For this reason it would be interesting to find an easy tool to diagnose this apparently non-pathogenic virus.
In recent years, synthetic peptides that mimic specific epitopes of infectious agents have been used in diagnostic systems for various diseases. The main drawback of this approach is that peptides representing topographic B-cell epitopes are poorly recognised by antibodies. There is a tendency toward using chimeric to avoid those problems and to improve the sensitivity and specificity of the assays.
In this thesis, new putative epitopes located both in envelope and in nonstructural proteins of GBV-C/HGV were synthesized using solid-phase chemistry. The corresponding synthetic peptides, obtained in linear, multimeric and cyclic forms, were used as antigens in ELISA and in real-time bioespecific interaction measurements (SPR) to detect GBV-C/HGV-specific antibodies in different panels of human sera. Furthermore, CD and FT-IR have been used in conjunction to characterize the conformational changes therein with synthetic constructs that could explain their different antigenicity.
The results obtained showed, on one hand, that the combination of different antigens seems to be necessary to ensure good sensitivity and more specificity and, on the other hand, that cyclic compounds show higher ability to recognize anti-GBV-C/HGV antibodies than its parent peptide. Our results offer a new approach to develop new diagnostic peptide based biosensors for serodiagnosis of GBV-C/HGV infection.
Mancke, Lida Victoria [Verfasser], and Maura [Akademischer Betreuer] Dandri. "Humanized chimeric uPA mouse model for the study of Hepatitis B and D virus interactions and preclinical drug evaluation / Lida Victoria Mancke. Betreuer: Maura Dandri." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2013. http://d-nb.info/1032990562/34.
Повний текст джерелаSilva, Synara Alexandre Araujo. "Desenvolvimento de uma técnica molecular para detecção e quantificação do vírus da hepatite G (GBV-C/HGV)." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5134/tde-22062010-123341/.
Повний текст джерелаIntroduction: The Hepatitis G (GBV-C / HGV) agent is a flavivirus. Its genome is composed of single stranded RNA of positive polarity, replicating in lymphocytes. Up to now, it hasn\'t been implicated in any disease associated to human beings. Recent studies demonstrate that persons co-infected by the viruses GBV-C / HGV and HIV have a slower rate of progression to AIDS and death, although some studies have failed in demonstrating such effects. Objective: To determine the soroprevalence and viremia (qualitative) of GBV-C / HGV in samples from HIV-infected women. To develop a methodology of Real-Time PCR for GBV-C / HGV viral load determination. Methods: The presence of antibody and GBV-C/HGV RNA was evaluated in 253 plasma samples from HIV infected women, collected between 1997-99. An immunoenzymatic assay (EIA kit for anti-E2, Roche(TM)) was applied to obtain the seroprevalence while the polymerase chain reaction (PCR), nested PCR, and a standardized Taqman based real-time PCR (RT-PCR), were used in the assessment of viral RNA. For the viral load, a standard-curve was made with serial dilutions of a plasma bag containing GBV-C/ HGV RNA+, and results were expressed in random units/mL, in comparison to the reference matherial. Results: Of the 253 samples tested, 64 were positive for anti-E2 (25.3%), 36 RNA positive by PCR (14.2%), and 57 (22.5%) where both nested PCR and real-time PCR RNA positive, for a total exposure index of 48%. The mean viral load was of 1.396 RU/mL (13.625 - 1.1 RU/mL). GBV-C/HGV Viremia was not correlated to HIV laboratorial parameters, i.e. CD4 and HIV-RNA counts. Conclusions: A simple, fast and efficient system for the determination of GBV-C/HGV viral load was developed, presenting appropriate sensitivity and specificity, allowing reproducible quantification of GBV-C RNA in stored plasma samples. The methodology allows simultaneous analysis of a large number of samples, being appropriate for clinical studies. The prevalence of exposition to this agent in the studied female population is high, probably a consequence of the common sexual way of transmission of the agents.
Vilar, Fernando Crivelenti. "Expressão do HLA-G no tecido hepático de pacientes coinfectados com HIV/HCV." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17138/tde-24082014-194222/.
Повний текст джерелаChronic liver disease induced by hepatitis C virus (HCV) infection has recently become one of the most common comorbidities in patients who are infected with the human immunodeficiency virus (HIV) in developed countries. HIV/HCV coinfected patients show faster progression to cirrhosis and its complications than the HCV monoinfected patients. Even though the responsible mechanisms for this evolution have not been entirely clarified yet, the expression of the HLA-G molecule, a HLA from the non-classic Ib class, with well-known properties of negatively regulating the immune response, may be related to the liver disease progression. The aims of the present work were to analyze the HLA-G expression profile in the liver micro ambience of HIV/HCV coinfected patients and to identify possible host factors, HIV or HCV, that may be related to the HLA-G expression on the liver biopsy. For this purpose, 57 liver biopsies of HIV/HCV coinfect patients, in which immunohistochemistry for HLA-G had been performed, were retrospectively analyzed according the HLA-G expression on the hepatic tissue. Other histopathological features in the liver biopsies, such as fibrosis degree, inflammatory activity, iron deposition and fat were also evaluated. The polymorphism of insertion or deletion in 14-base pairs of the 3`non-translated region of exon 8 of the HLA-G gene, which is related to the production of HLA-G messenger RNA, was evaluated in 43 of the patients. Also, the polymorphism of IL-28B, related to the response to HCV treatment, was evaluated in 44 of them. Biochemical and virological features of HIV and HCV were also evaluated. The HCV genotype 1 was the most prevalent (87.75%), especially the subgenotype 1a (60%). The expression of HLA-G was observed in 38 (66.7%) samples of the liver biopsies, and it was most frequent in moderate and severe stages of fibrosis than in the mild stages (94.1% x 55%, P < 0.01). There was no established relationship between HLA-G and other parameters studied. Although the progression to cirrhosis in the context of HIV/HCV coinfection is a complex process modulated by many factors, the association of HLA-G expression with the intensity of the liver fibrosis may indicate the protein expression play an important role in the mechanisms that contribute to the progression of the disease, through the negative regulation of the immune response against HCV setting of a coinfection with HIV.
Fernández, Arauzo Leticia. "Péptidos sintéticos del GB virus C. Aplicación en el diagnóstico de infección y en el diseño de potenciales agentes terapéuticos contra el VIH-1." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/482076.
Повний текст джерелаGB virus C (GBV-C) (also formerly known as hepatitis G virus) is a non-pathogenic human virus. Its infection is more frequently in groups considered as high risk because it has similar routes of transmissions with other viruses such as hepatitis B virus, hepatitis C virus or human immunodeficiency virus (HIV). However, it is detected even in healthy people. There is a strong evidence for GBV-C association with ameliorated course of human immunodeficiency virus (HIV) disease, although its mechanism of action is yet to be determined. Thus, the study of the interaction between these viruses could give new therapeutic agents to HIV treatment. At present, there are no commercial systems to detect specific markers of GBV-C infection. In this thesis, the synthesis of branched peptide molecules was carried out by conjugating regions of the envelope protein E2 and the structural protein NS4 of the GBV-C virus. Afterwards, their antigenic capacity was evaluated. The ability of the synthesized molecules to inhibit cell fusion mediated by HIV-1 envelope protein was also studied in order to select potential inhibitors of virus entry into the cell. First of all, a detailed study of the E2 protein of GVB-C was carried out by preparing peptide microarrays with 124 linear sequences of this protein, using sera from patients infected with HIV-1 and healthy volunteers. Thus, potentially antigenic domains of the E2 protein of GBV-C were identified. After carrying out these assays and studying the accessibility profile of the potentially antigenic domain E2 (7-26), solid phase synthesis of linear, cyclic and branched peptides was carried out following an Fmoc/tBu strategy. Peptide constructions were characterized by HPLC, UPLC and mass spectrometry (ESI and MALDI-TOF) and purified by semipreparative HPLC. Subsequently, cell fusion assays were performed in order to evaluate the anti-HIV-1 activity of the peptide molecules derived from the N-terminal domain of the E2 protein of GBV-C. From this study, it could be concluded that the cyclic type constructions have a greater tendency towards a greater inhibition of HIV-1 entry in the cell. The ability to detect anti-GBV-C antibodies of all sequences and synthetic constructions were studied by the ELISA immunoenzymatic assay with sera from patients with chronic hepatitis C, patients undergoing hemodialysis, HIV-1 infected and sera from healthy volunteer donors. The results obtained demonstrated the potential diagnostic utility of the E2 region (7-26) of the GBV-C. Finally, the diagnostic value of the peptide domains identified by microarrays was evaluated with a panel of sera from patients infected with HIV-1. The combination of the peptide sequences studied allowed to establish a reactivity of 47% in the detection of anti-E2 antibodies of GBV-C in people infected with HIV-1. In addition, this technology has miniaturized the ELISA immunoenzymatic assay and it has demonstrated the usefulness of synthetic peptides as potential antigens for the development of a GBV-C infection diagnosis system.
劉定萍. "A Clinico-Virological Study of GB Virus c/Hepatitis G Virus and Search for Related Viruses." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/29285401340889019156.
Повний текст джерела國立臺灣大學
微生物學研究所
85
This study proceeded to the viral detection, epidemiological investigation, genome cloning and analysis of GB virus C/hepatitis G virus (GBV-C/ HGV). We detected serum viral RNA by reverse transcription-polymerase chain reaction (RT-PCR) and found higher GBV-C/HGV prevalences in drug abusers, hemophiliacs, patients with aplastic anemia, and HIV carriers. The result showed that the transmission of GBV-C/HGV is probably related to body fluid exchange. For the cloning of viral NS3 region, flanking primer method (Sorensen et al. , 1993) is useful for both 5'- and 3'-end extension except for Rapid Amplification of cDNA Ends (RACE) . We successfully obtained 582 base sequences from Taiwan strain NS3 region by these methods, and constructed an insert mutant for use in competitive PCR to quantitate GBV-C/HGV RNA. In the published reports, GBV-C/HGV genomes do not contain a full-length core gene. Since most virions are difficult to survive in absence ofnucleocapsid in the environment, the full-length core gene may exist but somehow wasn't cloned. We try to re-examine this hyposis but failed. Another interest is in some recipients who accepted GBV-C/HGV RNA positive blood didn't become infected. To investigate any viral difference, we compared the E1 and E2 region of viral RNA from donor sera and undertook the phylogenetic analysis. The results indicated that viral RNA from donor sera which cannot render recipients persistently infected did not belong to any specific genotypes or phylogenetic tree cluster. The possibilities of the other viral proteins or host neutralizing antibodies making such a difference were more likely. Another GB series virus- GB virus B (GBV-B)- causes hepatitis in tamarin and is more closely related to human hepatitis C virus (HCV) . We applied the sequences from GBV-B, HCV and Pestiviruses 5'-UTR consensus box to design two pairs of primers to do degenerated polymerase chain reaction for searching for the GBV-B related new human hepatitis virus. The strategy just began, still remained to be improved.
Schüttler, Christian G. [Verfasser]. "Einfluß des Hepatitis-C-Virus-Core-Proteins auf Transkriptionselemente des Hepatitis-B-Virus : ein Modell zur viralen Koinfektion / vorgelegt von Christian G. Schüttler." 2000. http://d-nb.info/96344560X/34.
Повний текст джерелаSathar, Mahomed Aslam. "GB Virus C / Hepatitis G Virus (GBV-C/HGV) infection in KwaZulu Natal, South Africa : its diagnosis, distribution and molecular epidemiology." Thesis, 2003. http://hdl.handle.net/10413/7916.
Повний текст джерелаThesis (Ph.D.)-University of Natal, 2003.
Borlang, Jamie Ellen. "Phenotypic characterization of a clinical HBV/G isolate relative to a co-infecting HBV/A strain and HBV/A/G recombinant strains." 2010. http://hdl.handle.net/1993/3929.
Повний текст джерелаDAI, Chia-Yen, and 戴嘉言. "The prevalence and clinical significance of hepatitis G virus infection in a hepatitis C hyperendemic area in southern Taiwan." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/17291575783256192811.
Повний текст джерела高雄醫學院
醫學研究所
87
HCV is the second cause of chronic hepatitis and hepatocellular carcinoma in Taiwan . To shed light on the status and clinical characteristics of the HGV infection in the HCV hyperendemic area, we studied the presence of HGV viremia and anti-E2 antibodies, the relation of HGV infection to the clinical characteristics, the factors influencing the seroconversion of anti-E2 antibodies and possible association of hepatitis B, C and G viruses among residents of Mashagou where is a highly endemic area for HCV located in the southwestern coastal area of Taiwan.as an HCV hyperendemic area model. Materials and Methods: Serum of two hundred residents of Mashagou were tested for alanine aminotransferase (ALT), HBsAg, second-generation HCV antibody (anti-HCV), HCV RNA and HGV RNA by nested RT-PCR using 5'untranslated region (5'UTR)-specific primers, and anti-E2 antibody by an enzyme linked immunosorbent assay. The prevalence of serum HGV RNA and anti-E2 antibodies were also investigated in 400 consecutive volunteer blood donors. Statistical analyses: Frequency was compared between groups using the chi-square test or Fisher's exact test, and group means were compared using the t test. Stepwise logistic regression method was used to analyze the study data. Results: The prevalence of HGV viremia, anti-E2 and HGV exposure among residents of Mashagou were significantly higher than those among volunteer blood donors (17.0% vs. 3.3%, 25.5% vs. 7.5% and 39.5% vs. 10.3%, respectively; all p<0.001). The prevalence of HGV exposure was significantly higher in individuals exposed to HCV than in those without HCV exposure (45.8% vs. 24.1%, respectively; p=0.005). None of sex, age, ALT levels, marker of chronic HBV infection and HCV genotype distribution was related to the exposure of HGV. The rate of anti-E2 seroconversion in Mashagou patients exposed to HGV (57.0%) was similar to that of blood donor (68.3%). Male had significant higher rate of anti-E2 seroconversion than female did (71.0% vs. 47.9%; p=0.04) in Mashagou rather than blood donors (male: 71.0%; female: 60.0%). None of age, ALT levels, markers of chronic HBV infection and HCV exposure was related to anti-E2 seroconversion. There was no difference of serum ALT levels between HGV viremic and non-viremic individuals in each group by the status of HBsAg and HCV RNA.The mean ALT level was significantly higher in those positive for HCV RNA with or without other viral markers (HBsAg and HGV RNA) than in those negative for HCV RNA. Based on multiple logistic regression analyses, significant factors associated ALT elevation was HCV RNA with odds ratio and 95% confidence interval of 6.96 and 2.60-18.7. Conclusions: In HCV hyperendemic area of Taiwan, HGV infection is closed associated with HCV infection. With minimal pathogenic-effect of HGV infection after exposure of HGV, HCV rather than HGV played the most important clinical hepatopathic role. HGV had lower persistent infection rate than HCV and there was no influence on the recovery from HGV infection by HCV infection. The reasons for the higher seroconversion rate in male than female in HCV endemic area can not be provided and need further evaluation.
Ruf, Torsten Werner. "Die Hepatitis G Virus (HGV, GBV- C) Infektion bei Hämophiliepatienten : Prävalenz, Risikofaktoren und klinischer Verlauf /." 2006. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014933717&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Повний текст джерелаWurpts, Gerda. "Nachweis und pathogenetische Bedeutung zirkulierender Immunkomplexe und RNA-bindender Proteine in Seren Hepatitis-G-Virus infizierter Personen /." 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=013138979&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Повний текст джерела