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Статті в журналах з теми "Heart rate variability; overweight; type 2 diabetes"
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Sjoberg, Nicholas, Grant D. Brinkworth, Thomas P. Wycherley, Manny Noakes, and David A. Saint. "Moderate weight loss improves heart rate variability in overweight and obese adults with type 2 diabetes." Journal of Applied Physiology 110, no. 4 (April 2011): 1060–64. http://dx.doi.org/10.1152/japplphysiol.01329.2010.
Повний текст джерелаАнотація:
The objective of this study was to determine the effects of weight loss on heart rate variability (HRV) and its association with traditional cardiovascular disease risk factors in overweight and obese patients with type 2 diabetes. Forty five patients [body mass index (BMI) 35.4 ± 0.7 kg/m2; age 56.5 ± 1.1 yr] with type 2 diabetes followed an energy-restricted diet (6–7 MJ/day) for 16 wk. Body weight, blood pressure, glucose, insulin, insulin resistance [homeostasis model assessment index 2 (HOMA2)], glycosylated hemoglobin (HbA1c), total cholesterol, low-density lipoproteins (LDL), high-density lipoproteins (HDL), triglycerides, resting HR, and HRV were measured before and after the intervention period. Mean reduction in body weight was 11.1 ± 1.0 kg (10%), with significant reductions in blood pressure (−10%), total cholesterol (−15.9%), LDL (−17.7%), HDL (−7.5%), triglycerides (−21.2%), glucose (−23.4%), insulin (−37.6%), HOMA2 (−40.1%), and HbA1c (−14.5%) ( P ≤ 0.05 for all variables). There were increases in several HRV components, including total power (1,370 ± 280 to 2,045 ± 280 ms2), low-frequency power (345 ± 70 to 600 ± 108 ms2), SD of normal to normal intervals (SDNN; 35.0 ± 2.5 to 43.0 ± 2.7 s), and square root of the mean squared differences of successive normal to normal intervals (RMSSD; 23.0 ± 3.5 to 32.0 ± 3.1 s), and a decrease in HR (69.0 ± 1.3 to 60.0 ± 1.2 beats/min) ( P ≤ 0.03 for all variables). Changes in HR, SDNN, total power, and low-frequency power correlated with change in BMI ( P < 0.05). In addition to improvements in traditional cardiovascular and metabolic risk factors, weight loss improves HRV in overweight and obese patients with type 2 diabetes.
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Jain, Jitendra Kumar, and Ranjan Maheshwari. "Normal Body Mass Index and Heart Rate Variability." Defence Life Science Journal 4, no. 3 (July 15, 2019): 175–81. http://dx.doi.org/10.14429/dlsj.4.13732.
Повний текст джерелаАнотація:
The autonomic nervous system (ANS) works in synergy with the Endocrine system that affects the body-mass and height and in turn the body mass index (BMI). The ANS activities are often assessed with one index that is heart rate variability (HRV). Reduced HRV has been reported in underweight (low BMI) and overweight (high BMI) individuals, but there is scarce information available on the relationship between normal BMI and HRV. Further, as per WHO expert consultation report, the Asian population has higher percentage of body fat than their European counterparts, therefore Asian people may have greater risk factors for type 2 diabetes and cardiovascular disease even below the existing upper edge of normal BMI. Thus it was recommended by WHO to consider the intermediate cutoff points within the normal BMI range as 18.5 Kg/m2, 20 Kg/m2, 23 Kg/m2, and 25 Kg/m2 for the Asian population. Therefore, the present study was aimed to investigate ANS activity among intermediate cutoff points of normal BMI using HRV. Seventy young individuals participated in the non-invasive and benign study. Subjects were divided into three groups based on their BMI as per the recommendation of the WHO report; NB1 (18.5<BMI≤20), NB2 (20<BMI<23) and NB3 (23<BMI<25). For all the subjects, 10 min of electrocardiogram was recorded and short term HRV analysis was carried out. Student t test was carried out to find the significance of study parameters in BMI groups. The BMI was correlated with HRV measures using Spearman’s correlation method. Statistically significant negative correlation was found between BMI and various HRV parameters. The sympathovagal balance was comparable in NB1 and NB2 group whereas it shifted towards sympathetic dominance in NB3 group. Higher sympathetic activity for BMI greater than 23 in Indian youth may lead to predictability of risks associated with overweight and obesity
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Baye, Estifanos, Kirthi Menon, Maximilian PJ de Courten, Arul Earnest, James Cameron, and Barbora de Courten. "Does supplementation with carnosine improve cardiometabolic health and cognitive function in patients with pre-diabetes and type 2 diabetes? study protocol for a randomised, double-blind, placebo-controlled trial." BMJ Open 7, no. 9 (September 2017): e017691. http://dx.doi.org/10.1136/bmjopen-2017-017691.
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IntroductionCarnosine, an over-the-counter food supplement, has a promising potential for the prevention and treatment of chronic diseases such as type 2 diabetes (T2DM), cardiovascular and neurodegenerative diseases through its anti-inflammatory, antiglycation, antioxidative and chelating effects. We have previously shown that supplementation with carnosine preserves insulin sensitivity and secretion in non-diabetic overweight and obese individuals. The effect of carnosine on cardiometabolic risk and related cognitive outcomes in patients with pre-diabetes and T2DM has thus far not been studied. We therefore aim to investigate whether supplementation with carnosine improves cardiometabolic health and cognitive function in patients with pre-diabetes and T2DM.Methods and analysisWe will employ a parallel design randomised controlled trial. Fifty participants with pre-diabetes (impaired fasting glycaemia and impaired glucose tolerance) and T2DM (with HbA1c level < 8%) aged between 18 to 70 years will be randomly assigned to the intervention or control group. At baseline, participants will undergo a medical review and series of tests including anthropometric measurements (body mass index, a dual X-ray absorptiometry and peripheral quantitative computed tomography scan), an oral glucose tolerance test, cardiovascular measurements (central blood pressure, endothelial function and arterial stiffness), cognitive function, physical activity measurement, heart rate variability and liver fibroscan as well as questionnaires to assess dietary habits, sleep quality, depression and quality of life. The intervention group will receive 2 g of carnosine daily in two divided doses while the control group will receive identical placebo capsules for 14 weeks. All baseline measurements will be repeated at the end of the intervention. The change in glycaemic, cardiovascular and cognitive parameters as well as other measures will be compared between the groups.Ethics and disseminationThis study is approved by the Human Research Ethics Committee of Monash Health and Monash University, Australia. The findings will be disseminated via peer-reviewed publications and conference presentations.Trial registrationNCT02917928; Pre-results.
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Quist, Jonas S., Marie M. Jensen, Kim K. B. Clemmensen, Hanne Pedersen, Natasja Bjerre, Joachim Størling, Martin B. Blond, et al. "Protocol for a single-centre, parallel-group, randomised, controlled, superiority trial on the effects of time-restricted eating on body weight, behaviour and metabolism in individuals at high risk of type 2 diabetes: the REStricted Eating Time (RESET) study." BMJ Open 10, no. 8 (August 2020): e037166. http://dx.doi.org/10.1136/bmjopen-2020-037166.
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IntroductionThe aim of this study is to investigate the effects of time-restricted eating (TRE) on change in body weight and describe changes in behaviour and metabolism in individuals at high risk of type 2 diabetes.Methods and analysisThe REStricted Eating Time (RESET) study is a randomised controlled parallel-group open-label trial. 100 women and men with (1) overweight (body mass index (BMI)≥25 kg/m2) and prediabetes (glycated haemoglobin 39–47 mmol/mol); or (2) obesity (BMI≥30 kg/m2) will be randomised to a control group (habitual living) or TRE (self-selected 10-hours eating window within the period from 06:00 to 20:00 in a 1:1 ratio. Testing is scheduled at baseline and after 6 weeks (mid-intervention), 3 months (post-intervention) and 6 months (follow-up). The primary outcome is change in body weight after 3 months of intervention. Secondary outcomes include changes in body composition; measures of glucose metabolism including glycaemic variability, hormones and metabolites; subjective and metabolic markers of appetite, food preferences and reward; dietary intake; physical activity, sleep, chronotype; gastric emptying, gastrointestinal transit time and motility; respiratory and glycolytic capacities; the plasma proteome and metabolome; blood pressure, resting heart rate and heart rate variability; and resting energy expenditure and substrate oxidation. Motivation and feasibility will be examined based on interviews at baseline and after 3 months. After the 3-month intervention, a 3-month follow-up period and subsequent testing are scheduled to assess maintenance and longer-term effects.Ethics and disseminationThe study has been approved by the Ethics Committee of the Capital Region of Denmark (H-18059188) and the Danish Data Protection Agency. The study will be conducted in accordance with the Declaration of Helsinki. Results from the study will address whether TRE is effective and feasible in improving health outcomes in individuals at risk of lifestyle-related diseases and can potentially inform the design of feasible health recommendations.Trial registration numberNCT03854656.
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El Ayash, Heba, Reem Shawar, Maurice Puyau, and Fida Bacha. "RF02 | PMON308 Hyperglycemia Is the Main Determinant of Cardiac Autonomic Dysfunction in Youth With Obesity Across the Spectrum of Glycemic Regulation." Journal of the Endocrine Society 6, Supplement_1 (November 1, 2022): A638. http://dx.doi.org/10.1210/jendso/bvac150.1321.
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Abstract Heart Rate Variability (HRV) results from the autonomic nervous system activity, it is a non-invasive marker of cardiac autonomic function. Loss of parasympathetic function (PNS) and sympathetic (SNS) override, reflected in decreased HRV, is one of the earliest subclinical manifestations of cardiac autonomic dysfunction. Lower HRV is associated with increased risk of cardiac events in adults. We aimed to characterize HRV in normal weight and overweight children with and without dysglycemia and to investigate the determinants of HRV in these youth, including body composition, glycemia measures, beta-cell function and inflammatory markers. We evaluated 94 adolescents (50 males/44 females), age 15 ± 2.1 years; 21 normal weight with normal glucose tolerance (NW-NGT), 23 overweight with NGT (OW-NGT) and 50 overweight with impaired glucose regulation (OW-IGR) including prediabetes (n= 27) and type 2 diabetes (n= 23). They underwent assessment of anthropometrics, body composition (DXA scan), inflammatory markers (hs-CRP and TNF-α), fasting labs and 2-hour oral glucose tolerance test (OGTT) with determination of glucose and insulin concentration. EndoPat was used to measure HRV: frequency-domain indices [high-frequency (HF) reflecting PNS, low-frequency (LF) reflecting both PNS and SNS, and LF/HF (higher is worse) estimating the ratio between SNS and PNS] and time-domain indices [the inter-beat interval of normal sinus beats (NN) and the standard deviation of NN (SDNN) measuring overall HRV, the square root of the mean squared difference of successive NN (RMSSD) and the NN intervals differing by more than 50 milliseconds (NN50) measuring PNS activity]. LF/HF was higher in the OW-IGR group compared with NW and OW-NGT (p=0.005). After controlling for sex, race and Tanner stage, fasting glucose (FBG) negatively correlated with NN (r=-0.22,p=0.04), SDNN (r=-0.21,p=0.05), RMSSD (r=-0.3,p=0.004), NN50 (r=-0.27,p=0.01) and HF (r=-0.26,p=0.02). LF/HF was positively related to FBG (r=0.39,p<0.001), 2hr-glucose (r=0.31,p=0.004) and HbA1c (r=0.22,p=0.04), and negatively with the insulinogenic index (r=-0.27,p=0.02), but not fasting insulin or HOMA-IR; LF/HF also correlated with percent body fat (r=0.22,p=0.04), hs-CRP (r=0.33,p=0.002) and TNF-α (r=0.38,p=0.006). In a linear regression model with LnLF/HF as the dependent variable and percent body fat, hs-CRP, FBG and HOMA-IR as the independent variables, FBG (beta=0.39,p=0.003) and hs-CRP (beta=0.21,p=0.09) were the significant determinants of LnLF/HF independent of age, sex, race and Tanner stage as covariates (R2= 0.23,p=0.013). Youth with impaired glucose metabolism have evidence of early subclinical cardiac autonomic dysfunction with decreased HRV, loss of parasympathetic function and sympathetic overdrive as reflected by lower time-domain indices, lower HF and higher LF/HF, related to glycemia and systemic inflammation. Presentation: Saturday, June 11, 2022 1:00 p.m. - 2:00 p.m., Saturday, June 11, 2022 1:12 p.m. - 1:17 p.m., Monday, June 13, 2022 12:30 p.m. - 2:30 p.m.
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Stuckey, Melanie I., and Robert J. Petrella. "Heart Rate Variability in Type 2 Diabetes Mellitus." Critical Reviews in Biomedical Engineering 41, no. 2 (2013): 137–47. http://dx.doi.org/10.1615/critrevbiomedeng.2013008103.
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Silva-e-Oliveira, Julia, Pâmela Marina Amélio, Isabela Lopes Laguardia Abranches, Dênis Derly Damasceno, and Fabianne Furtado. "Heart rate variability based on risk stratification for type 2 diabetes mellitus." Einstein (São Paulo) 15, no. 2 (June 2017): 141–47. http://dx.doi.org/10.1590/s1679-45082017ao3888.
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ABSTRACT Objective To evaluate heart rate variability among adults with different risk levels for type 2 diabetes mellitus. Methods The risk for type 2 diabetes mellitus was assessed in 130 participants (89 females) based on the questionnaire Finnish Diabetes Risk Score and was classified as low risk (n=26), slightly elevated risk (n=41), moderate risk (n=27) and high risk (n=32). To measure heart rate variability, a heart-rate monitor Polar S810i® was employed to obtain RR series for each individual, at rest, for 5 minutes, followed by analysis of linear and nonlinear indexes. Results The groups at higher risk of type 2 diabetes mellitus had significantly lower linear and nonlinear heart rate variability indexes. Conclusion The individuals at high risk for type 2 diabetes mellitus have lower heart rate variability.
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Velcheva, Irena, Petar Damianov, Stefka Mantarova, and Nadia Antonova. "Hemorheology and heart rate variability in patients with diabetes mellitus type 2." Clinical Hemorheology and Microcirculation 49, no. 1-4 (2011): 513–18. http://dx.doi.org/10.3233/ch-2011-1500.
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Sacre, J. W., C. L. Jellis, T. H. Marwick, and J. S. Coombes. "Reliability of heart rate variability in patients with Type 2 diabetes mellitus." Diabetic Medicine 29, no. 7 (June 19, 2012): e33-e40. http://dx.doi.org/10.1111/j.1464-5491.2011.03557.x.
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Pencic-Popovic, Biljana, Vera Celic, Zoran Cosic, Milena Pavlovic-Kleut, Zorica Caparevic, Nada Kostic, Branislav Milovanovic, Aleksandra Sljivic, and Biljana Stojcevski. "Heart rate variability and increased risk for developing type 2 diabetes mellitus." Vojnosanitetski pregled 71, no. 12 (2014): 1109–15. http://dx.doi.org/10.2298/vsp1412109p.
Повний текст джерелаАнотація:
Background/Aim. To our knowledge there are no data about the relationship between elevated risk for developing type 2 diabetes mellitus (DM2) and altered cardiac autonomic function. The aim of this study was to evaluate the association between heart rate variability (HRV) and slightly increased risk for DM2. Methods. We evaluated 69 subjects (50.0 ? 14.4 years; 30 male) without DM2, coronary artery disease and arrhythmias. The subjects were divided into two groups according to the Finnish Diabetes Risk Score (FINDRISC): group I (n = 39) included subjects with 12 > FINDRISC ? 7; group II (n = 30) subjects with FINDRISC < 7. HRV was derived from 24-h electrocardiogram. We used time domain variables and frequency domain analysis performed over the entire 24-h period, during the day (06-22 h) and overnight (22-06 h). Results. Standard deviation of the average normal RR intervals was significantly lower in the group with increased risk for DM2 compared to the group II (127.1 ? 26.6 ms vs 149.6 ? 57.6 ms; p = 0.035). Other time domain measures were similar in both groups. The group I demonstrated significantly reduced frequency domain measures, total power - TP (7.2 ? 0.3 ln/ms2 vs 7.3 ? 0.3 ln/ms2; p = 0.029), and low frequency - LF (5.9 ? 0.4 ln/ms2 vs 6.3 ? 0.6 ln/ms2; p = 0.006), over entire 24 h, as well as TP (7.1 ? 0.3 ln/ms2 vs 7.3 ? 0.3 ln/ms2; p = 0.004), very low frequency (6.2 ? 0.2 ln/ms2 vs 6.3 ? 0.2 ln/ms2; p = 0.030), LF (5.9 ? 0.4 ln/ms2 vs 6.2 ? 0.3 ln/ms2; p = 0.000) and high frequency (5.7 ? 0.4 ln/ms2 vs 5.9 ? 0.4 ln/ms2; p = 0.011) during the daytime compared to the group II. Nocturnal frequency domain analysis was similar between the groups. The low diurnal frequency was independently related to elevated risk for diabetes mellitus (beta = -0,331; p = 0.006). Conclusion. The obtained results suggest that even slightly elevated risk for developing diabetes mellitus may be related to impaired HRV.
Дисертації з теми "Heart rate variability; overweight; type 2 diabetes"
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Swaminathan, Krishnan. "The Effects of Aldosterone blockade on Blood pressure, Endothelial function, Glycaemic control, Key hormomes and Heart Rate Variability in Hypertensive patients with Type 2 Diabetes." Thesis, University of Dundee, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500634.
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Karjalainen, J. (Jaana). "Cardiovascular autonomic function in coronary artery disease patients with and without type 2 diabetes:significance of physical activity and exercise capacity." Doctoral thesis, Oulun yliopisto, 2013. http://urn.fi/urn:isbn:9789526202723.
Повний текст джерелаАнотація:
Abstract Coronary artery disease (CAD) and type 2 diabetes (T2D) are associated with cardiovascular autonomic dysfunction, which is widely used as a predictor of mortality in cardiovascular diseases. The determinants of autonomic dysfunction in CAD patients with or without T2D are not well known. The aim of this thesis was to examine the determinants of cardiovascular autonomic function in healthy subjects and CAD patients with and without T2D. A second aim was to study the prognostic value of autonomic function in the patient population. A third aim was to study the effects of exercise prescriptions on physical activity and exercise capacity in the patient groups. The association between heart rate (HR) variability and physical activity was examined by means of 24-hour recordings in 45 healthy adults. The determinants and prognostic value of autonomic function, measured by HR recovery, HR variability, and HR turbulence, were assessed in 1060 CAD patients (50% were patients with T2D). Physical activity was measured before and after a six-month exercise prescription in 44 CAD patients without T2D and 39 CAD patients with T2D. In healthy patients, short-term HR variability indexes and the complexity properties of HR were influenced by physical activity, whereas long-term HR variability indexes remained relatively stable at various activity levels, making them robust indexes for assessment of autonomic function during ambulatory conditions. In CAD patients, exercise capacity was the most important determinant of autonomic function in addition to physical activity, age, presence of T2D, and left ventricular systolic function. During a 2-year follow-up, autonomic dysfunction predicted cardiovascular events only in CAD patients with T2D, but did not provide independent prognostic information after multivariate adjustment when high-sensitivity C-reactive protein, a marker of inflammation, remained as an independent predictor. CAD patients with T2D were physically less active than patients without T2D. Exercise prescription promoted a more active lifestyle and improved exercise capacity in both patient groups. In conclusion, cardiovascular autonomic dysfunction in CAD patients with and without T2D is closely related to low exercise capacity and physical activity, which both can be increased by exercise prescriptions. Autonomic dysfunction predicts short-term cardiovascular events only in CAD patients with T2D, but is not as strong an independent predictor as low-grade inflammationTiivistelmä Autonomisen hermoston toiminnan häiriö on yleinen komplikaatio sepelvaltimotaudissa ja tyypin 2 diabeteksessa (T2D), ja sen tiedetään olevan itsenäinen kuolleisuutta ennustava tekijä. Autonomista säätelyä selittäviä tekijöitä ei kuitenkaan tunneta hyvin. Tässä tutkimuksessa selvitettiin autonomisen hermoston toimintaa selittäviä tekijöitä kolmessa ryhmässä: osa tutkittavista oli terveitä, osalla oli sepelvaltimotauti ja T2D, ja osalla pelkästään sepelvaltimotauti. Lisäksi tutkittiin, miten autonominen säätely vaikuttaa sepelvaltimotautipotilaiden ennusteeseen sekä miten liikuntaohjelma vaikuttaa heidän fyysiseen aktiivisuuteensa ja suorituskykyynsä. Sykevaihtelun ja fyysisen aktiivisuuden välistä yhteyttä selvittävään tutkimukseen osallistui 45 tervettä henkilöä. Autonomisen hermoston toimintaa selittäviä tekijöitä ja sen ennustearvoa tutkittiin 1060 sepelvaltimotautipotilaalta, joista puolet sairasti T2D:ta. Näistä potilaista valittiin satunnaisotannalla kuuden kuukauden liikuntaohjelmaan ja fyysisen aktiivisuuden mittauksiin 44 sepelvaltimotautipotilasta, joilla ei ollut T2D:ta, ja 39 potilasta, jotka sairastivat T2D:ta. Terveillä henkilöillä lyhyen aikavälin sykevaihtelumuuttujat olivat yhteydessä fyysiseen aktiivisuuteen, mutta pitkän aikavälin sykevaihtelumuuttujissa tätä yhteyttä ei havaittu. Sepelvaltimotautipotilailla vahvimmiksi autonomista säätelyä selittäviksi tekijöiksi osoittautuivat maksimaalinen suorituskyky, fyysinen aktiivisuus, ikä, T2D ja vasemman kammion ejektiofraktio. Poikkeava autonominen säätely ennusti sydän- ja verisuonitautitapahtumia kahden vuoden seurannan aikana vain T2D:ta sairastavilla sepelvaltimotautipotilailla, mutta sillä ei ollut itsenäistä ennustearvoa, kun vakioitiin muilla riskitekijöillä. Lopulta ainoa huonon ennusteen merkki oli tulehdustilaa kuvaava herkkä CRP. T2D:ta sairastavat sepelvaltimotautipotilaat olivat fyysisesti passiivisempia kuin pelkästään sepelvaltimotautia sairastavat. Yksilöllinen liikuntaohjelma lisäsi korkean intensiteetin fyysistä aktiivisuutta ja paransi suorituskykyä molemmissa potilasryhmissä. Tämän tutkimuksen tulokset osoittavat, että sepelvaltimotautipotilailla autonomisen hermoston toiminnan häiriö on yhteydessä vähäiseen fyysiseen aktiivisuuteen ja heikkoon fyysiseen kuntoon. Molempiin tekijöihin voidaan vaikuttaa positiivisesti liikuntaohjelmalla. Poikkeava autonominen säätely ennustaa lyhyen aikavälin sydän- ja verisuonitautitapahtumia vain T2D:ta sairastavilla sepelvaltimotautipotilailla. Se ei kuitenkaan ole yhtä vahva itsenäinen ennustaja kuin tulehdusta kuvaava herkkä CRP
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Cruz, Angélica Cristiane da [UNESP]. "Efeitos de diferentes intensidades de exercício resistido sobre a modulação autonômica da frequência cardíaca e metabolismo láctico de diabéticos tipo 2." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153597.
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Introdução: Durante o exercício físico, os ramos simpático e parassimpático, por meio dos mecanismos centrais e periféricos, interagem entre si causando ajustes nas respostas da frequência cardíaca (FC) de acordo com a carga, os quais podem estar alterados na presença de Diabetes Melitus tipo 2. Essas alterações também podem ocorrer durante o momento de recuperação pós exercício resistido. Objetivo: Investigar os ajustes autonômicos cardíacos durante exercício físico resistido dinâmico com diferentes níveis de estresse metabólico, abaixo e acima do limiar de anaerobiose. Material e método: A amostra foi composta por 14 indivíduos diabéticose 10 indivíduos aparentemente saudáveis, de ambos os sexos com idade a partir 40 anos. Na condição de repouso a frequência cardíaca (FC) e os intervalos R-R (iR-R) foram analisados no domínio do tempo, da frequência e pelo plot de Poincaré. O limiar de anaerobiose (LA) foi determinado durante o exercício de extensão de joelho (mesa romana) e aplicado dois testes: um com 10% abaixo e outro com 10% acima do LA, com duração de um minuto cada um, mantendo respiração espontânea e sem apneia. A FC e os iRR foram registrados continuamente durante 65s de repouso, durante a contração isotônica e 5 minutos de recuperação. A partir desses dados serão estudados os ajustes da FC e da sua variabilidade durante o esforço e também no período de recuperação. Resultados e conclusão: Os resultados do nosso estudo mostraram que houve alterações mais significativas do lactato mensurado pelo sangue a partir de 30% de 1RM para o GC bem como para o grupo DM2, este último com alterações mais expressivas quando comparado também com as cargas de 40 e 50% de 1RM. Quanto a VFC foi observado uma redução significativa em relação ao repouso nos índices RMSSD e SD1 do CG e nenhuma alteração significativa no grupo DM2, apresentando em ambos os grupos uma tendência de estabilização após 30% de 1RM e não sendo possível encontrar o LA, determinado pela VFC, nessa população em especifico submetida a um protocolo incremental de exercício resistido de membros inferiores.
Introduction: During exercise, the branchs sympathetic and parasympathetic, central and peripheral mechanisms interact inducing adjustments on of heart rate (HR) responses according to the intensity, which can be changed in the presence of type 2 diabetes mellitus. Those changes may occur during the time after resistance exercise recovery. Objective: To investigate cardiac autonomic adjustments during dynamic exercise with different levels of metabolic stress, below and above the anaerobic threshold, and in the recovery period in diabetics patients. Methods: The sample consisted by 14 diabetcs subjects and 10 apparently healthyof both sexes aged starting 40 years old. At rest HR and R-R intervals (R-Ri) wereanalyzed in the time and frequency domain and the Poincaré plot. The anaerobic threshold (AT) was determined during the performance of knee extension exercise in the Roman table and was applied two tests: one with 10 % below and the other 10 % above the AT, during one minute, keeping spontaneous breathing and no apnea. The HR and R-Riwere recorded continuously for 65 seconds at rest, during isotonic contraction and 5 minutes of recovery. From these data, were studied the adjustments of HR,their variability during exercise and also during the recovery period. Results and conclusion: The results of our study show that you have more than 30% of 1RM for the GC as well as for the DM2 group, the latter containing more expressive when compared also with as 40 and 50% loads of 1RM. What is a HRV was observed a significant reduction in relation to the rest in the RMSSD and SD1 indices of CG and soon without a GM2 group, showing in both groups a tendency of stabilization after 30% of 1RM and not being possible to find the LA, determined by HRV, in this specific population submitted to an incremental protocol of resisted lower limb exercise.
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Moura, Sílvia Cristina Garcia de. "Influência da manobra postural ativa e do diabetes mellitus tipo 2 na variabilidade da frequência cardíaca de homens de meia idade." Universidade Federal de São Carlos, 2012. https://repositorio.ufscar.br/handle/ufscar/5285.
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Previous issue date: 2012-02-29Financiadora de Estudos e Projetos
OBJECTIVE Evaluate the heart rate variability (HRV) of individuals with Type 2 diabetes, in the supine and in response to active postural maneuver from the supine to orthostatic position, by means of linear and non linear analysis and correlate these data. RESEARCH DESIGN AND METHODS Sixteen men with type 2 diabetes (DM) and sixteen control subjects (CG), age-range from 40 to 65 year were studied. The R-R intervals were recorded with a Polar RS800CX for 10 minutes in supine and 10 minutes in the orthostatic position. We assessed HRV using spectral (LFnu, HFnu and LF/HF), symbolic (0V%, 1V%, 2LV% and 2ULV%) analysis, Shannon (SE) and conditional entropy (complexity Index - CI and Normalized Complexity Index- NCI). RESULTS The DM presented higher sympathetic modulation (LFnu) in the supine position than the CG. In active postural maneuver for the variables LFnu and HFnu, DM showed no significant responses. Irrespective of position DM presented lower complexity than CG for SE. The same did not occur with conditional entropy, however, in both groups a reduction in values of entropies was observed with postural change. The reduction in complexity observed by SE was related to an increase in sympathetic modulation (0V%). CONCLUSION Our study showed that DM had higher sympathetic modulation in the supine position, which may be related to less complexity of HRV in this population. In addition, DM did not present the expected response of the autonomic nervous system to active postural maneuver for the variables LFnu and HFnu.
OBJETIVO Avaliar a variabilidade da frequência cardíaca (VFC) de indivíduos com diabetes mellitus tipo 2, na posição supina e em resposta a manobra postural ativa de supino para ortostático, por meio de análise linear e não linear e correlacioná-las. MÉTODOS Foram avaliados dezesseis homens com diabetes mellitus tipo 2 (DM) e dezesseis sujeitos controle (GC), na faixa etária de 40 a 65 anos. Os intervalos R-R (iRR) foram captados por um Polar RS800CX durante 10 minutos na posição supina e 10 minutos na posição ortostática. Avaliou-se a VFC utilizando análises espectral (BFun, AFun e BF/AF), simbólica (0V%, 1V%, 2LV% e 2ULV%), entropia de Shannon (ES) e condicional (índice de complexidade - IC e índice de complexidade normalizado - ICN). RESULTADOS O DM apresentou maior modulação simpática (BFun) na posição supina do que o GC. Na manobra postural ativa para as variáveis BFun e AFun o DM não mostrou resposta significativa. Independentemente da posição DM apresentou menor complexidade (menor ES) do que o GC. O mesmo não ocorreu com a entropia condicional, entretanto em ambos os grupos foi observada redução nos valores das entropias com a mudança postural. A redução da complexidade observada pela ES foi relacionada ao aumento da modulação simpática (0V%). CONCLUSÃO Nosso estudo mostrou que DM apresentou maior modulação simpática na posição supina, a qual pode estar relacionada com a menor complexidade da VFC nessa população. Além disso, DM não apresentou resposta esperada do sistema nervoso autonômico à manobra postural ativa para as variáveis BFun e AFun.
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Bassi, Daniela. "Efeitos do treinamento físico combinado no desempenho cardiovascular e metabólico em indivíduos diabéticos – ensaio clínico randomizado e controlado." Universidade Federal de São Carlos, 2016. https://repositorio.ufscar.br/handle/ufscar/8088.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
The thesis consists of three studies described below. Study I, entitled: Poor glycemic control impacts the linear dynamic and nonlinear heart rate in type 2 diabetes mellitus (T2DM) whose objective was to evaluate the relationship between glycemic control and cardiac autonomic modulation in patients with T2DM without autonomic neuropathy cardiovascular. This is a descriptive, prospective and cross-sectional study. The resting heart rate (HR) and RR interval (RR intervals) were obtained and calculated by linear methods and nonlinear heart rate variability (HRV). Insulin, HOMA-IR, fasting glucose and HbA1c were obtained by blood tests. We concluded that the poor glycemic control associated with cardiac autonomic modulation indices in patients with type 2 diabetes, though not exhibit cardiovascular autonomic neuropathy. Following the Study II, entitled Type 2 diabetes coexistence of effects and systemic hypertension (SH) in HRV and cardiorespiratory performance, which aimed to evaluate the influence of hypertension in cardiac autonomic neuropathy and cardiorespiratory fitness in subjects with diabetes mellitus type 2. The evaluation included collection of iRR for further analysis of HRV, it was collected in the supine position followed by incremental cardiopulmonary exercise test (ICET) on a cycle ergometer. The results revealed a greater loss of HRV when there is overlapping of diseases. Additionally, there was an association of responses affected HRV with cardiopulmonary function markers impaired to exercise. Finally, the Study III, entitled: Potential effects on cardiorespiratory and metabolic status after a physical aerobic concurrent training program and has resisted in diabetic volunteers - Randomized Study and controlled. The objective was to evaluate metabolic profile, glycemic control and exercise capacity in diabetic volunteers after participating in an aerobic and resistance concurrent training program (AR-CT) for a period of three months. The evaluation included the ICET the cycle ergometer and 1-RM tests. Ventilation, hemodynamic measurements were performed during the ICET and peripheral muscle strength by isokinetic dynamometer. The program consisted of 30 minutes of aerobic exercise and 30 minutes of resistance exercise of upper and lower limbs. The results showed an improvement in glycemic control and lipid profile in addition to increased peripheral muscle strength and exercise capacity. These data together suggest that the exercise program constitutes an important strategy in the treatment of type 2 diabetes, producing both physiological and functional improvements in this population.
A tese constou de três estudos descritos a seguir. O Estudo I, intitulado: Pobre controle glicêmico impacta a dinâmica linear e não-linear da frequência cardíaca no diabetes mellitus tipo 2 (DM2), cujo objetivo foi avaliar a relação entre controle glicêmico e modulação autonômica cardíaca em indivíduos com DM2 sem neuropatia autonômica cardiovascular. Trata-se de um estudo descritivo, prospectivo e transversal. A frequência cardíaca de repouso (FC) e intervalo RR (iRR) foram obtidos e calculados por métodos lineares e não-lineares de variabilidade de frequência cardíaca (VFC). Insulina, HOMA-IR, glicemia de jejum e HbA1c foram obtidas por análises sanguíneas. Concluímos que o controle glicêmico deficiente relaciona-se com índices de modulação autonômica cardíaca em indivíduos com DM2, ainda que não apresentem neuropatia autonômica cardiovascular. Na sequência, o Estudo II, intitulado: Efeitos da coexistência da diabetes tipo 2 e da hipertensão arterial sistêmica (HAS) na VFC e no desempenho cardiorrespiratório, que objetivou avaliar a influência da HAS na modulação autonômica cardíaca e aptidão cardiorrespiratória de sujeitos com diabetes mellitus tipo 2. A avaliação incluiu coleta de dos iRR, para posterior análise da VFC, a mesma foi coletada na posição supina seguida de teste de exercício cardiopulmonar incremental (TECI) no cicloergômetro. Os resultados revelaram um maior prejuízo da VFC quando há sobreposição das doenças. Adicionalmente, houve associação das respostas prejudicadas da VFC com marcadores de função cardiopulmonar prejudicada ao exercício. Finalmente, o Estudo III, intitulado: Potenciais efeitos no status cardiorrespiratório e metabólico após um programa de treinamento físico concorrente aeróbio e resistido em diabéticos – Estudo Randomizado e Controlado. O objetivo foi avaliar perfil metabólico, controle glicêmico e capacidade de exercício em voluntários diabéticos após participarem de um programa de treinamento concorrente aeróbio e resistido (TC-AR) por um período de 3 meses. A avaliação incluiu o TECI no cicloergômetro, exames laboratoriais, teste isocinético e teste de 1-RM. Foram realizadas medidas ventilatórias, hemodinâmicas durante o TECI bem como da força muscular periférica por meio da dinamometria isocinética. O programa foi constituído por 30 minutos de exercícios aeróbios e 30 minutos de exercícios resistidos de membros superiores e inferiores. Os resultados mostraram melhora do controle glicêmico e do perfil lipídico, além de aumento da força muscular periférica e da capacidade de exercício. Esses dados juntos sugerem que o programa de exercícios constitui-se uma importante estratégia no tratamento de DM2, produzindo melhoras tanto fisiológicas como funcionais nessa população.
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Sjoberg, Nicholas J. "The modification of heart rate variability in normal, overweight and type 2 diabetic individuals." Thesis, 2013. http://hdl.handle.net/2440/81002.
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The aim of this thesis was to improve our understanding of the effects that dietary therapies have on improving cardiac autonomic activity in healthy and diabetic people, particularly the effects of omega 3 polyunsaturated fatty acids (PUFA) on healthy people. Research conducted to date suggests that diet has specific effects on cardiac autonomic activity; however, much of this research has ignored the underlying influence of specific therapies and weight loss. In this thesis, heart rate variability (HRV) is used to assess cardiac autonomic activity. Cardiac autonomic activity is chiefly responsible for the beat to beat control of heart rate and has been implicated in sudden cardiac death and prognosis of an adverse cardiovacular event following myocardial infarct. The first experiment was designed to systematically examine the dose-response changes in cardiac ANS activity and vascular compliance after supplementation with omega 3 polyunsaturated fatty acids. In sixty seven overweight middle aged volunteers, HRV, cardiac sympathetic activity (assessed via low frequency component of HRV), parasympathetic activity (assessed by the high frequency component of HRV), Low Frequency/High Frequency (LF/HF) ratio (representing the balance of sympathetic/parasympathetic nervous activity on heart rate), heart rate (HR), arterial compliance, systolic and diastolic blood pressure were assessed during rest. All variables showed the greatest change in the highest dose group. Arterial compliance and the LF/HF ratio changed in a dose-dependent manner with the omega 3 PUFAs. These results suggest that the observed relationships between fish oil dose and changes in arterial compliance and LF/HF suggest that regular fish oil supplementation can improve the regulation of HR, HRV and consequently blood pressure by increasing parasympathetic regulation of cardiac autonomic tone in a dose-dependent manner. In the second experiment twenty healthy, young male subjects were subjected to graded lower body negative pressure (LBNP) before and after a 6 week dietary supplement intervention of omega 3 PUFAs. Both periods of LBNP were immediately followed by venepuncture to assess lipid and omega 3 content of the blood cells. After the intervention of omega 3 PUFAs an improvement in cardiac autonomic activity (HRV frequency measures) together with a reduction in HR demonstrated that cardiac autonomic activity was improved during rest. Graded LBNP significantly reduced overall HRV and increased the LF/HF ratio of the frequency domain. After the 6 week intervention of omega 3 PUFAs, the autonomic control of heart rate was improved at the highest level of LBNP. Omega 3 PUFAs were significantly increased in the treatment group. In conclusion, the changes in HR and HRV measures during orthostatic stress demonstrated a cardiovascular response likely to be caused by increasing parasympathetic regulation of cardiac autonomic tone in young active males. These mutual changes may reduce CVD risk from an early age and provide further justification for increased intakes of fish oil. In the third experiment forty nine type 2 diabetic middle aged subjects undertook a 16 week dietary weight loss intervention. Before and after the trial, HRV measures were recorded for 10 minutes while the patients were supine and at rest for 10 minutes followed by venepuncture for metabolic and lipids markers. HRV frequency and time domain data indicated that weight loss produced an improvement in cardiac autonomic activity and the mean level of cardiac PNS activity (assessed via the root mean square of the successive differences in R-R intervals, RMSSD) during rest. The observed changes in cardiac ANS activity were attributed to weight loss only, despite similar reductions in several metabolic and cardiovascular blood markers. The results of this study suggest that a calorically restricted diet has favourable effects on cardiac ANS activity and implicate weight loss as a mediator of these effects. The results of this thesis indicate that dietary intervention in people with and without disease, particularly type 2 diabetes, may specifically influence cardiac autonomic activity, which may improve cardiovascular health outcomes. Moreover, the observed effects of diet on cardiac autonomic activity support the notion that weight loss and omega 3 PUFAs have positive cardiovascular health outcomes. The results of the thesis demonstrate that in order to comprehensively understand the effects of dietary therapeutics on cardiac autonomic activity, it is essential that concomitant changes in HRV are considered.Thesis (Ph.D.) -- University of Adelaide, School of Medical Sciences, 2013
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Brozic, Anka. "Effects of exercise on arterial stiffness, heart rate variability and inflammatory marker hs-CRP in type 2 diabetes." 2008. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=771965&T=F.
Повний текст джерелаЧастини книг з теми "Heart rate variability; overweight; type 2 diabetes"
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Ciobanu, D. M., A. E. Crăciun, I. A. Vereşiu, C. Bala, and G. Roman. "Ambulatory Heart Rate Variability Correlates with High-Sensitivity C - Reactive Protein in Type 2 Diabetes and Control Subjects." In International Conference on Advancements of Medicine and Health Care through Technology; 12th - 15th October 2016, Cluj-Napoca, Romania, 17–20. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-52875-5_4.
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Ferdousi, Sultana, and Phurpa Gyeltshen. "Type 2 Diabetes Mellitus: Cardiovascular Autonomic Neuropathy and Heart Rate Variability." In Type 2 Diabetes - From Pathophysiology to Cyber Systems. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95515.
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Type 2 Diabetes Mellitus is associated with both macro- and microvascular complications. One among the latter, is cardiovascular autonomic neuropathy (CAN). CAN is attributed to cardiac arrhythmias and sudden death. Underlying pathogenesis of cardiac autonomic neuropathy is chronic hyperglycemia induced oxidative stress causing neuronal necrosis, apoptosis and death, leading to the sympathetic and parasympathetic nerve dysfunction. The balance between sympathetic and parasympathetic nervous system is reflected by heart rate variability (HRV). HRV describes “the variations of both instantaneous heart rate and R-R intervals which in turn reflects the cardiac autonomic nervous control”. HRV measured at rest is a marker of autonomic nerve function status. Thus, HRV test is recommended to diagnose diabetic CAN. Time domain parameters predominantly reflect overall autonomic activity and parasympathetic nervous system (PNS) modulations. Frequency domain parameters either reflect, sympathetic nervous system (SNS) activity, PNS activity, or the balance between the two activities. Nonlinear HRV indices marks PNS influences, SNS influences and sympatho-vagal balance. Almost all these HRV parameters are remarkably reduced in T2DM due to cardiac autonomic dysfunction. HRV is an important simple and noninvasive diagnostic tool to detect CAN.
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Tudpor, Kukiat, Chatcharida Saisawai, Sasina Kaewpho, and Amaraporn Jitseeda. "Psychological Stress Is a Risk Factor for Type 2 Diabetes Mellitus in College Students." In pHealth 2021. IOS Press, 2021. http://dx.doi.org/10.3233/shti210619.
Повний текст джерелаАнотація:
Type 2 diabetes mellitus (T2DM) is multifactorial disease. This cross-sectional study was aimed to investigate relationship between stress and risk for T2DM in college students. Seven-hundred participants (350 T2DM risk and 350 non-T2DM risk groups). Stress index levels and heart rate variability (HRV) were respectively measured as primary and secondary outcomes. Results showed that both T2DM-risk and non-T2DM-risk groups had temporary stress, but the T2DM-risk group had significantly higher level of psychological stress (P < .001). For the HRV, the T2DM-risk group had significantly lower levels of parasympathetic proxies (lnHF, SDNN, and RMSSD) (P < .001). Chi-square (χ2) test showed significant correlation of the stressful state with T2DM risk (χ2 = 159.372, P < .001, odds ratio (OR) = 9.326). In conclusion, psychological stress is a risk factor for T2DM in college students. Early detection, monitoring, and treatments of psychological stress should be implemented in this group of population.
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Patil, Prasadgouda, Vijay Bhaskar Reddy, and Ashokumar P. "Optimal Classification Process using Fuzzy C-Means Neural Network for Effective prediction of Cardiac arrest due to Diabetes." In Data Science and Intelligent Computing Techniques, 1–12. 2023rd ed. Soft Computing Research Society, 2023. http://dx.doi.org/10.56155/978-81-955020-2-8-1.
Повний текст джерелаАнотація:
In recent scores, diabetes mellitus (DM)is regarded as a chronic illness and one of the leading critical health challenges throughout the earth. About eighty percent of demise occurs because of DM(Type II) which could be avoided by the earlier diagnosis of persons with this threat. Nevertheless, presently machine learning techniques can be employed for diabetics’ detection very precisely. We are proffering a health care monitoring system comprising ECG sensors. The criteria that have a considerable volume of significance will be sensed by the ECG sensors that remain important for remote monitoring of the sick person. A mobile app observance will be employed for consistently monitoring the sick person’s ECG and diverse data extraction approaches will be executed upon the ECG wave for extracting features to properly prognosis heart illnesses. Hence, this study proffers the employment of a metaheuristic optimization algorithm called Real Coded Binary Ant Bee Colony (RC-BABC) for optimized feature choosing, and ReliefF methodology will be employed for excerpting the features and computing the features’ scores centered upon the disparities in feature values and class values betwixt nearby cases. An effectual attempt will be carried out for detecting cardiac demist at early phases emerging out of the intensity of DMin which feature prognosis before heart rate variability assessment will be executed. The DM’sfeatures would be analyzed out of the diabetic’s dataset for detecting the reason for abrupt cardiac arrest. Next, the excerpted features are classified employing the Fuzzy C-means Neural Network (FCNN). The performance analysis is carried out to exhibit that FCNN executes properly in prognosticating the illnesses. The proffered FCNN paradigm attains 97% and 84% of testing and training (t&t) accuracy, 93% and 82% of t&t specificity, 95% and 81% of t&t sensitivity and 92% and 85% of t&tF1-score.
Тези доповідей конференцій з теми "Heart rate variability; overweight; type 2 diabetes"
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Tarvainen, Mika P., David J. Cornforth, Pekka Kuoppa, Jukka A. Lipponen, and Herbert F. Jelinek. "Complexity of heart rate variability in type 2 diabetes - effect of hyperglycemia." In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2013. http://dx.doi.org/10.1109/embc.2013.6610809.
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Rathod, SR, Leena Phadke, UM Chaskar, and CY Patil. "Machine Learning Techniques for Predicting Type 2 Diabetes Mellitus Risk using Heart Rate Variability Features." In 2021 12th International Conference on Computing Communication and Networking Technologies (ICCCNT). IEEE, 2021. http://dx.doi.org/10.1109/icccnt51525.2021.9579746.
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Novikov, Roman, Liudmila Zhukova, and Maxim Novopashin. "Possibility to Detect Glycemia with Heart Rate Variability in Patients with Type 2 Diabetes Mellitus in a Non-Invasive Glycemic Monitoring System." In 2019 Actual Problems of Systems and Software Engineering (APSSE). IEEE, 2019. http://dx.doi.org/10.1109/apsse47353.2019.00030.
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Kurnikova, Irina, Shirin Gulova, Tatiana Nikishova, Nikolay Kislyy, Sophia Buturlina, and Oksana Demina. "Frequency Indicators of Heart Rate Variability in Assessing the Effectiveness of Antihypertensive Therapy in Patients With Metabolic Disorders." In Human Interaction and Emerging Technologies (IHIET-AI 2022) Artificial Intelligence and Future Applications. AHFE International, 2022. http://dx.doi.org/10.54941/ahfe100875.
Повний текст джерелаАнотація:
The data of 87 patients with diabetes had presented, allowing identifying the relationship between the initial vegetative status and the effectiveness of antihypertensive drugs according to the analysis of heart rate variability. The effectiveness of the therapy was monitored based on the evaluation of daily ECG and blood pressure monitoring data. The effectiveness of therapy depended on the compensation or decompensation of diabetes in patients with cardiac autonomic neuropathy. In patients with DT1 and cardiac autonomic neuropathy (CAN), unsatisfactory compensation was accompanied by hypersympathicotonia, and pronounced clinical efficacy of moxonidine occurred in 92.7% (38 people) regardless of compensation. Unsatisfactory compensation of type 2 diabetes was accompanied by activation of parasympathetic reactions. It was not only reduced the effectiveness of moxonidine, but in some cases created undesirable effects, such as an increase not only in the total spectrum power (TSP), but also in the ULF spectrum to 42.6 ± 7.1%, which did not allow to consider the level of care provided sufficient. To achieve the effect, combination therapy with antihypertensive drugs of other pharmacological groups was required. Insufficient effectiveness of therapy in patients of this group was associated with pronounced changes in autonomic regulation.