Статті в журналах з теми "Hallett Cove"

In coastal sections at Hallett Cove and Sellicks Beach, south of Adelaide, and at Redbanks section on Kangaroo Island, the Brunhes/Matuyama polarity transition (780 ka) is identified in the strongly oxide-mottled Ochre Cove Formation. At all 3 sections, the Ochre Cove Formation is overlain by a calcareous grey-green aeolian clay, called Ngaltinga Clay, which in turn is overlain by calcareous sediments of the Taringa and Christies Beach Formations. The marked change from an oxide-dominated weathering regime to a carbonate-dominated weathering regime, estimated to have occurred at about 500–600 ka, is interpreted as a major arid shift in regional climates. Similar arid shifts are known from Lake Bungunnia in the Murray Basin and Lake Lefroy in southern Western Australia, where changes from lacustrine clays to evaporites and dune sediments are estimated to have occurred between 400 and 700 ka, and about 500 ka, respectively. An increase in aeolian dust accession in south-eastern Australia, consistent with increased aridity in the interior source area, occurred after 780 ka, and was probably coeval with increased dust input to Tasman Sea sediments since 350 ka. Between 600 and 900 ka, oxygen isotope fluctuations in deep-sea cores showed a pronounced change in frequency, from a 40 ka (obliquity dominated) to a 100 ka (eccentricity dominated) pattern. At the same time, glacial-interglacial amplitudes increased, with a marked enrichment of glacial d18O values consistent with larger continental based ice-sheets. Colder global temperatures, and lower sea levels during glacials, may have played a part in the mid Pleistocene arid shift recorded in southern Australia. Associated variations in the strength of the warm Leeuwin Current may also have affected regional rainfall patterns in southern Australia.

Abstract. The COnvective Precipitation Experiment (COPE) was designed to investigate the origins of heavy convective precipitation over the southwestern UK, a region that experiences flash flooding due to heavy precipitation from slow-moving convective systems. In this study, the microphysical and dynamical characteristics of developing turrets during 4 days in July and August 2013 are analyzed. In situ cloud microphysical measurements from the University of Wyoming King Air and vertically pointing W-band radar measurements from Wyoming Cloud Radar are examined, together with data from the ground-based NXPol radar. The 4 days presented here cover a range of environmental conditions in terms of wind shear and instability, resulting in a similarly wide variability in observed ice crystal concentrations, both across days as well as between clouds on individual days. The highest concentration of ice was observed on the days in which there was an active warm-rain process supplying precipitation-sized liquid drops. The high ice concentrations observed (>100 L−1) are consistent with the production of secondary ice particles through the Hallett–Mossop process. Turrets that ascended through remnant cloud layers above the 0 ∘C level had higher ice particle concentrations, suggesting that entrainment of ice particles from older clouds or previous thermals may have acted to aid in the production of secondary ice through the Hallett–Mossop process. Other mechanisms such as the shattering of frozen drops may be more important for producing ice in more isolated clouds.

This paper reports on the remapping of a carefully documented vegetation plot at Cape Hallett (72°19′S 170°16′E) to provide an assessment of the rates of vegetation change over decadal time scales. E.D. Rudolph, in 1962, mapped in detail the vegetation of a site approximately 28 m by 120 m at Cape Hallett, Victoria Land, Antarctica. This site was relocated and remapped in January 2004 and changes were assessed using GIS techniques. This appears to be the longest available time period for assessing vegetation change in Antarctica. The analysis indicated that considerable change had occurred in moss and algae distribution patterns and this seems to have been caused by increased water supply, particularly in wetter areas. There was also evidence of some change in lichen distribution. The extent of the change indicates that vegetation cover can be used for monitoring change in areas as extreme as the Ross Sea region. For this analysis to be successful it was important that the mapping techniques used were totally explicit and could easily be replicated. Fortunately, Rudolph had defined his cover classes and the site was also clearly marked. The application of GIS mapping techniques allows the mapping to be more explicitly defined and easily replicated.

Abstract Background and Aims Water limitation is an important determinant of the distribution, abundance and diversity of plant species. Yet, little is known about how the response to limiting water supply changes among closely related plant species with distinct ecological preferences. Comparison of the model annual species Arabidopsis thaliana with its close perennial relatives A. lyrata and A. halleri, can help disentangle the molecular and physiological changes contributing to tolerance and avoidance mechanisms, because these species must maintain tolerance and avoidance mechanisms to increase long-term survival, but they are exposed to different levels of water stress and competition in their natural habitat. Methods A dry-down experiment was conducted to mimic a period of missing precipitation. The covariation of a progressive decrease in soil water content (SWC) with various physiological and morphological plant traits across a set of representative genotypes in A. thaliana, A. lyrata and A. halleri was quantified. Transcriptome changes to soil dry-down were further monitored. Key Results The analysis of trait covariation demonstrates that the three species differ in the strategies they deploy to respond to drought stress. Arabidopsis thaliana showed a drought avoidance reaction but failed to survive wilting. Arabidopsis lyrata efficiently combined avoidance and tolerance mechanisms. In contrast, A. halleri showed some degree of tolerance to wilting but it did not seem to protect itself from the stress imposed by drought. Transcriptome data collected just before plant wilting and after recovery corroborated the phenotypic analysis, with A. lyrata and A. halleri showing a stronger activation of recovery- and stress-related genes, respectively. Conclusions The response of the three Arabidopsis species to soil dry-down reveals that they have evolved distinct strategies to face drought stress. These strategic differences are in agreement with the distinct ecological priorities of the stress-tolerant A. lyrata, the competitive A. halleri and the ruderal A. thaliana.

The article presents an analysis of the distribution and development of pink snow mold (pathogen Microdochium nivale (Fr.) Samuels & I.C. Hallett) on winter cereal crops in the Republic of Belarus and in the South of Russia. Pink snow mold is currently one of the most harmful diseases of winter cereal crops, as it can cause damage not only to various parts of the plants, but also lead to their complete death. The intensity of the disease development mainly depends on weather conditions in the autumn-spring period, namely, on the duration of snow cover, its height and the rate of melting in spring. We determined the dependence of the disease development progress on agroclimatic conditions. There is a description of weather conditions in combination with a gradation of the disease development level in the Republic of Belarus and in Krasnodar Krai (southern Russia) during the epiphytotic and depressive years of the pink snow mold development. The article provides a retrospective analysis of the crops infected with pink snow mold and the treated cereal crops in southern Russia in 2011 -2019.

Israrlı takip fiili 5237 sayılı Türk Ceza Kanunu’nun 123/A. maddesinin yürürlüğe girmesiyle birlikte artık müstakil bir suçtur. Bu düzenleme, bireyin huzurlu bir ortamda, rahatsız edilmeden, belirli bir sükûnet, psikolojik rahatlık ve esenlik içinde yaşamını sürdürmesini ve bu suretle kişilerin manevi varlığını korumak ve geliştirme hakkını temin etmeyi amaçlamaktadır. Israrlı takip, kasten işlenebilen neticeli bir suçtur. Huzur ve sükûn bozma suçunun aksine bu suç genel ve tamamlayıcı nitelikte değildir; işlendiğinde başlıbaşına uygulanır. Çalışmada suçun TCK m. 123/A’daki düzenleniş şekline ve gerekçesine yer verilerek, hukuki konusu, faili, mağduru, unsurları, ortaya çıkış biçimleri, nitelikli halleri, yaptırımı ve muhakeme usulü incelenmiştir. Böylece, düzenlemenin kadına yönelik şiddetle mücadelenin etkinliğini artırma amacına hizmet edip etmediğinin de ortaya konulması planlanmaktadır.

In the face of climate variability and change, science in Antarctica needs to address increasingly complex questions. Individual small studies are being replaced by multinational and multidisciplinary research programmes. The Latitudinal Gradient Project (LGP) is one such approach that combines a series of smaller studies under a single broad hypothesis to provide information that uses a gradient in latitude as a surrogate for environmental gradients, particularly climate. In this way latitudinal differences can be used to indicate climate change differences. The Key Questions for the LGP were developed via national workshops in Italy, New Zealand, and the USA and via two international workshops at SCAR conferences. Science and logistics are currently jointly shared by New Zealand, Italy and the USA, and cover marine and inland ecosystem studies along the Victoria Land coast from 72° to 78°S with plans for extensions to 85°S. The LGP forms part of the SCAR Programme Evolution and Biodiversity in Antarctica. This Special Issue summarizes some of the work in the first three years of the LGP (2002–2005), between McMurdo Sound and Cape Hallett, to form a basis for future comparative studies as the research shifts along the latitudinal span in the next decade.

Abstract. During the Late Pleistocene–Holocene, the Ross Sea Ice Shelf exhibited strong spatial variability in relation to the atmospheric and oceanographic climatic variations. Despite being thoroughly investigated, the timing of the ice sheet retreat from the outer continental shelf since the Last Glacial Maximum (LGM) still remains controversial, mainly due to a lack of sediment cores with a robust chronostratigraphy. For this reason, the recent recovery of sediments containing a continuous occurrence of calcareous foraminifera provides the important opportunity to create a reliable age model and document the early deglacial phase in particular. Here we present a multiproxy study from a sediment core collected at the Hallett Ridge (1800 m of depth), where significant occurrences of calcareous planktonic and benthic foraminifera allow us to document the first evidence of the deglaciation after the LGM at about 20.2 ka. Our results suggest that the co-occurrence of large Neogloboquadrina pachyderma tests and abundant juvenile forms reflects the beginning of open-water conditions and coverage of seasonal sea ice. Our multiproxy approach based on diatoms, silicoflagellates, carbon and oxygen stable isotopes on N. pachyderma, sediment texture, and geochemistry indicates that abrupt warming occurred at approximately 17.8 ka, followed by a period of increasing biological productivity. During the Holocene, the exclusive dominance of agglutinated benthic foraminifera suggests that dissolution was the main controlling factor on calcareous test accumulation and preservation. Diatoms and silicoflagellates show that ocean conditions were variable during the middle Holocene and the beginning of the Neoglacial period at around 4 ka. In the Neoglacial, an increase in sand content testifies to a strengthening of bottom-water currents, supported by an increase in the abundance of the tycopelagic fossil diatom Paralia sulcata transported from the coastal regions, while an increase in ice-rafted debris suggests more glacial transport by icebergs.

Editors Note: The reviewers have rated the books on a scale of one to five stars. The highest ratings are given to books that fulfill their objectives and skillfully convey information to the chosen audience. Books are judged on appropriateness and completeness of detail for the targeted audience, quality of writing, editorial skill (especially multiauthored books), illustrations, and photography. It is hoped this code will aid the reader in selecting books for his or her permanent library. The rating scale is as follows: ***** Outstanding, a classic, should be on the shelf of anyone interested in the subject; **** Strong, well-written book with major contributions in some areas; *** Informative book that should be read, if not owned, by individuals with interest in the field; ** Some worthwhile information, but with deficiencies in writing style or completeness; * Major shortcomings, not recommended. ****Therapy with Botulinum Toxin, by Joseph Jankovic and Mark Hallet. 656 pages with illustrations. Marcel Dekker, Inc., New York, 1994. $195.00.

Natural organic fertilizers require microbial degradation for nitrogen (N) release, but their ability to promote rapid turfgrass establishment has not been well documented in newly constructed sand-based rootzones. This 2-year field study evaluated the influence of two general fertilizer and soil amendment programs for their effect on establishment and quality of three creeping bentgrass (Agrostis stolonifera L.) cultivars—`Crenshaw', `Penn G-2', and `Providence'. Turf was grown on a 4 sand: 1 sphagnum peat (by volume) rootzone mixture. Four treatments consisting of surface-applied synthetic fertilizer (SF; mostly water-soluble N in 1999 and methylene urea thereafter); surface-applied hydrolyzed poultry meal (PM); preplant-incorporated granular humate (GH) with surface-applied SF; and preplant-incorporated PM with surface-applied PM. Turf cover data collected 42 days after seeding (DAS) showed that the rate of establishment was SF+GH incorporated = SF surface-applied >PM surface-applied + PM incorporated >PM surface-applied. Turf cover was ≥96% among all treatments 90 DAS. Rootmass density was greater (18% to 29%) at 103 DAS in GH incorporated plots combined with SF, when compared to all other treatments, but no rootmass differences subsequently were observed. Soil microbial activity generally was highest in PM-treated plots during the first 14 months following seeding, but not thereafter. Turf treated with SF had less microdochium patch (Microdochium nivale (Fr.) Samuels and I.C. Hallett) and more bentgrass dead spot (Ophiosphaerella agrostis Dernoeden, M.P.S. Camara, N.R. O'Neill, van Berkum et M.E. Palm), when compared to PM-treated plots. Slightly less thatch developed in PM-treated turf when compared to plots receiving SF alone by the end of the second year. Penn G-2 and SF generally provided the best overall turf quality. This study demonstrated the beneficial effects of readily available N from SF for rapid establishment and that preplant incorporation of GH initially aided root development.

Abstract. Intense rainfall generated by convective clouds causes flash flooding in many parts of the world. Understanding the microphysical processes leading to the formation of precipitation is one of the main challenges to improving our capability to make quantitative precipitation forecasts. Here, we present microphysics observations of cumulus clouds measured over the Southwest Peninsula of the UK during the COnvective Precipitation Experiment (COPE) in August 2013, which are framed into a wider context using ground-based and airborne radar measurements. Two lines of cumulus clouds formed in the early afternoon along convergence lines aligned with the peninsula. The lines became longer and broader during the afternoon as a result of new cell formation and stratiform regions forming downwind of the convective cells. Aircraft penetrations at −5 °C showed that all the required conditions of the Hallett–Mossop (H–M) ice multiplication process were met in developing regions, and ice concentrations up to 350 L−1 were measured in the mature stratiform regions, indicating that secondary ice production was active. Detailed sampling focused on an isolated liquid cloud that glaciated as it matured to merge with a band of cloud downwind. In the initial cell, a few drizzle drops were measured, some of which froze to form graupel; the ice images are most consistent with freezing drizzle, rather than smaller cloud drops forming the first ice. As new cells developed in and around the cloud, ice concentrations up to two orders of magnitude higher than the predicted ice nuclei concentrations began to be observed and the cloud glaciated over a period of 12–15 min. Ice splinters were captured by supercooled drizzle drops causing them to freeze to form instant-rimers. Graupel and columns were observed in cloud penetrations up to the −12 °C level, though many ice particles were mixed-habit due to riming and growth by vapour diffusion at multiple temperatures. Frozen drizzle/raindrops initially made up the majority of precipitation-sized particles in the H–M zone, while ice splinters required time to grow by vapour diffusion. It is therefore clear that the freezing of supercooled drizzle drops not only provides a pathway to advance the onset of the H–M process, it also accelerates glaciation and the formation of precipitation once it has begun. Accurate representation of both the warm rain and H–M processes, including their interactions with each other and cloud dynamics, appears key to determining the timing and location of precipitation.

Abstract. We present microphysical observations of cumulus clouds measured over the southwest peninsula of the UK during the COnvective Precipitation Experiment (COPE) in August 2013, which are framed into a wider context using ground-based and airborne radar measurements. Two lines of cumulus clouds formed in the early afternoon along convergence lines aligned with the peninsula. The lines became longer and broader during the afternoon due to new cell formation and stratiform regions forming downwind of the convective cells. Ice concentrations up to 350 L−1, well in excess of the expected ice nuclei (IN) concentrations, were measured in the mature stratiform regions, suggesting that secondary ice production was active. Detailed sampling focused on an isolated liquid cloud that glaciated as it matured to merge with a band of cloud downwind. In the initial cell, drizzle concentrations increased from ∼ 0.5 to ∼ 20 L−1 in around 20 min. Ice concentrations developed up to a few per litre, which is around the level expected of primary IN. The ice images were most consistent with freezing drizzle, rather than smaller cloud drops or interstitial IN forming the first ice. As new cells emerged in and around the cloud, ice concentrations up to 2 orders of magnitude higher than the predicted IN concentrations developed, and the cloud glaciated over a period of 12–15 min. Almost all of the first ice particles to be observed were frozen drops, while vapour-grown ice crystals were dominant in the latter stages. Our observations are consistent with the production of large numbers of small secondary ice crystals/fragments, by a mechanism such as Hallett–Mossop or droplets shattering upon freezing. Some of the small ice froze drizzle drops on contact, while others grew more slowly by vapour deposition. Graupel and columns were seen in cloud penetrations up to the −12 °C level, though many ice particles were mixed habit due to riming and growth by vapour deposition at multiple temperatures. Our observations demonstrate that the freezing of drizzle/raindrops is an important process that dominates the formation of large ice in the intermediate stages of cloud development. As these frozen drops were the first precipitation observed, interactions between the warm-rain and secondary ice production processes appear to be key to determining the timing and location of precipitation.

Abstract. The Cenozoic in southern Australia contains many foraminifera endemic to the region in neritic (intermediate- to shallow-water) facies. They were mostly epifaunal and inhabited waters to some 300 m deep. This endemism is first obvious in the later Eocene when Maslinella, Crespinina and Wadella, among others, evolved. More than half of the Eocene endemic species disappeared in the Eocene or Oligocene. There followed in the Oligocene the evolution of such species as Parrellina imperatrix and Astrononion centroplax. The Miocene was a time of slightly reduced endemism and is characterized by migration into the region of many larger (sub)tropical taxa such as Lepidocyclina and Cycloclypeus. The long-ranging genus Notorotalia emerged about 50 Ma ago and is still common in modern southern mid-latitude waters. The youngest common extant species which made their first appearance in the Pliocene–Quaternary include Discorbis dimidiatus and Parredicta porifera, both with a test up to 1.5 mm in diameter. A similar pattern has been recorded in New Zealand.Four phases of endemism can be recognized: later Eocene, Oligocene, Miocene and Pliocene–Quaternary. It appears that the four phases were all stimulated in response to major marine transgressions, respectively the Wilson Bluff ( = Khirthar), Aldingan, Clifton–Longfordian and Hallet Cove–Glanville transgressions. Probably they signal four important stages in the transformation of water masses along the southern continental margin.

Janus, the ancient Roman God of Gates and Doors had two faces: one looked into the past, and the other, into the future. Do neurons possess a Janus face when it comes to neurotransmitters, or a given neuron is to be forever solely γ-aminobutyric acid (GABA) ergic, glutamatergic, dopaminergic, peptidergic, or YOURPREFERREDTRANSMITTERergic? The answer is that the terminals of many neurons are homes to even more than two neurotransmitters. All this in spite of the “one neuron–one transmitter” usual misinterpretation of Sir Henry Hallett Dale's postulate, originally meant to indicate that a metabolic process taking place in the cell body can influence all processes of the same neuron. A large variety of neurons in the CNS, many of them GABAergic, produce and release chemicals that satisfy some of the criteria used to define neurotransmitters. The usual scenario for a dual-transmitter terminal is that the fast-acting transmitter such as GABA or glutamate is stored in regular synaptic vesicles, whereas a neuropeptide is stored in dense core vesicles ( 1 ). The vesicular zinc found in many glutamatergic terminals also may be considered to be a second neurotransmitter, based on its vesicular packaging with the aid of a specific vesicular transporter, and its postsynaptic actions through high-affinity binding sites and permeation through certain channels ( 2 ). Whenever a “fast” and a “slow” neurotransmitter are present in the same presynaptic terminal, it is customary to assume that their release can be differentially regulated ( 1 ). There is little convincing experimental support for this phenomenon in the mammalian CNS. The coexistence of two “fast” neurotransmitters in the same terminal is less frequent, but not unheard of. In neonatal sympathetic neurons cocultured with cardiac myocytes, norepinephrine and acetylcholine coexist and have opposite actions on the cardiac muscle cells ( 3 ). Very recently we learned that brain-derived neurotrophic factor acting at the low-affinity neurotrophin receptor p75NTR, perhaps as part of a programmed developmental switch, can convert the phenotype of the sympathetic neuron from noradrenergic to cholinergic ( 4 ). Other examples of two fast neurotransmitters released from the same neuron include GABA and glycine in interneurons of the spinal cord ( 5 ) and glutamate and dopamine in ventral midbrain dopamine neurons ( 6 ). Of all CNS neurons, the granule cells of the dentate gyrus appear to be the champions of neurotransmitter colocalization: glutamate, enkephalin, dynorphin, zinc, and finally GABA ( 2 , 7 – 9 ). With this many transmitters in a single neuron, there are probably different ways in which they can be released. Dynorphin and other opioid peptides can be released directly from the dendrites to inhibit excitatory transmission ( 8 ). A similar mechanism may take place for GABA, as described in cortical GABAergic neurons ( 10 ).

Abstract Abstract 1795 Introduction. The combination of fludarabine and cyclophosphamide (FC) has become the core combination of modern frontline chemotherapy for fit and young B-CLL patients (pts). Recently the association with rituximab to FC (IV administration) has been shown to increase the response and extend both progression free survival (PFS) and overall survival (OS) in untreated pts (Hallek et al., Lancet 2010). So far few data are available concerning the very long term outcome of pts treated by FC containing regimen. Methods. We previously reported a prospective phase II trial (Cazin et al., BJH 2008) of the oral combination of FC over 5 days in 75 patients with untreated B-CLL and less than 66 years old. The study was conducted between October 1999 and February 2001. Briefly, oral FC then demonstrated high efficacy with overall response rate (ORR) and complete response (CR) rate of 80% and 53% respectively despite the absence of rituximab in this regimen. We here propose to examine 10-year end points of progression-free survival (PFS), overall survival (OS), impact of genomic features, and risk of therapy-related myeloid neoplasm (t-MN) by updating survival data of all the pts incuded in this trial. Results. With a median follow-up of 10.7 years, the median 10-year OS was 51.7%. Responders presented better 10-year OS than non-responders (57% vs. 38%, p=0.031) but quality of response (CR vs. PR) did not significantly impact 10-year OS. A major prognostic impact of IGVH mutational status could be observed since 10-year OS was 81% for mutated patients vs. 44% for unmutated pts (p=0.012). The median 10-year PFS was 30% and clearly influenced by the mutational status (50% if mutated profile vs. 12% if unmutated profile, p=0.02). However there is no trend of a plateau and even long term responding patients still relapse with time. Finally, only one patient developed t-MN but 9 others presented solid neoplasms. Conclusion. Long-term follow-up of B-CLL patients prospectively treated in a phase II clinical trial demonstrates extended OS and PFS with oral FC without high risk of t-MN. Disclosures: No relevant conflicts of interest to declare.

Abstract This paper presents the most recent and detailed Holocene palynological research carried out on the Congolese Atlantic littoral, in the region of Pointe-Noire, as part of the ECOFIT program (CNRS-IRD). The results are obtained on two continental sedimentary sequences (core S2 from Songolo site: 4 degrees 45'51"S, 11 degrees 51'55"E, alt. 5 m and core 2 from Coraf site: 4 degrees 45'S, 11 degrees 51'E, alt. 1 m). Pollen data and interpretation are completed on the Songolo sequence by mineralogical (quartz, kaolinite, TOM) and isotopic (delta 13 C on organic matter) analysis allowing a continuous reconstruction of the Congolese littoral palaeoenvironments from 7000 yr. cal B.P. onwards. The Congolese coastal plain is today a mosaic of forest-grassland. Sandy open short savanna largely occurs with as dominant grass Loudetia arundinacea. Locally, Symphonia globulifera swamp forests are present along rivers and in flooded areas. Mangrove with Rhizophora is not well developed except along the Kouilou estuarine. The climate is characterized by mean annual precipitation not exceeding 1300 mm and temperature ranging between 22 and 25 degrees C. The core S2 from Songolo site was extracted using a piston corer. The coring site is today a peat building swamp with abundant Cyperus papyrus. The local dominant trees are Raphia and Alstonia. The presence of Elaeis guineensis (oil palm) and Mangifera indica (mango) testifies of a recent human occupation of this area. The core Coraf 2 was collected on the beach by manual penetration of PVC tube. On the two studied cores, dating control is provided by thirteen 14 C conventional and AMS dates performed on total organic matter. The ages are reported with equivalent ranges in calendar years. The present pollen, mineralogical and isotopic records, completed by previous other data (mainly macroflora remains), give new informations on vegetation and hydrological changes at local and regional scale since 7000 yr. cal B.P. on the Congolese littoral, in relation to climatic and sea level changes. The main conclusions can be summarized as follows. During the middle Holocene (7000-3000 yr. cal B.P.), expansion of swamp dense forests with Pandanus, Anthostema, Hallea, Symphonia globulifera, Syzygium, and also of mangrove (Rhizophora), as testified by pollen analysis, gives evidence of high rainfall which is also supported at Songolo by the abundance of kaolinite and quartz, an increase in the amorphous silica and delta 13 C low values typical of C 3 biomasse until 3000 yr. cal. B.P. At the same time, the occurrence in macroflora remains of trees such as Saccoglottis gabonensis, Ongokea gore and several species of Monopetalanthus that are found today in the Mont de Cristal forest in Gabon, under 2000-2500 mm of annual rainfall, confirms this climatic interpretation. A major change is registered ca. 3000 yr. cal B.P., characterized by the regression of the swamp forests which are replaced by herbaceous formations dominated by Cyperaceae and ferns, the disappearance of mangrove near the Songolo site, an important decrease in mineral influx (quartz and kaolinite) and increase in organic matter content. Increase in delta 13 C values during this period shows that most of the organic fraction derives from C 4 plants, probably linked to local expansion of Cyperus papyrus. This change, well known at this time on several sites from Central Atlantic Africa, is mainly linked to a progressive regional deterioration of climate towards aridity. On the Songolo site, the presence of fresh water taxa such as Nymphaea lotus supports an absence of marine water influence, indicating a sea level regressive episode well known, at the same time, along the West African coast. During the most recent period, despite more favourable climatic conditions (rainfall), no re-extension of littoral swamp forests is detected. These results are mainly related to the location of the studied sites, in an area of particularly intense human impact as shown by the occurrence of Elaeis guineensis (oil palm) in macroflora remains recovered from numerous archeological sites. The multidisciplinary data presented here correlate well with previous records from Central Atlantic Africa (Congo and Cameroon). The general similarity of the registered changes during the last 7000 yr cal B.P. strongly supports a regional climatic interpretation.

Abstract Introduction COVID-19 poses a serious concern for mB-cell NHL patients given their advanced age, high burden of comorbidities, and immune dysfunction. Limited by smaller sample sizes during the early period of the COVID-19 pandemic, previous studies were unable to thoroughly evaluate the impact of COVID-19 on patients with mB-cell NHL 1,2. We aim to describe demographics and clinical characteristics, outcomes, and risk factors associated with death and other severe outcomes among COVID-19 patients with mB-cell NHL in a large US nationwide database. Methods This retrospective cohort study was conducted using the Optum EHR database, comprising data from an integrated network of ambulatory and hospital care providers across the US. Patients with COVID-19 (diagnosis code of U07.1, U07.2, or a positive result of SARS-Cov-2 virus PCR or antigen tests) between Feb. 1, 2020 and Jan 7, 2021 (index date) and mB-cell NHL diagnosis prior to the COVID-19 diagnosis were included. Patients were excluded if they were under 18 years of age, had missing age or sex, or had <1year continuous eligibility prior to their index date (pre-index period). All baseline characteristics, including demographics and comorbidities, were determined during the one-year pre-index period. Severe outcomes, including death, hospitalization, ICU admission, and acute respiratory insufficiency (ARI), were evaluated within 30 days post-index date. Multivariable logistic regression was conducted to identify variables independently associated with severe outcomes. Results Among 2,767 patients with mB-cell NHL who were infected with SARS-CoV-2 between Feb. 1, 2020 and Jan. 7, 2021 (mean age±SD: 67.9 years±14.7, 53.9% male), majority were white (73.9%), followed by African American (10.9%), Hispanic (6.9%), and Asian (1.2%). The most common subtypes of mB-cell NHL were chronic lymphocytic leukemia/small lymphocytic lymphoma (26.9%), multiple myeloma (22.4%), diffuse large B-cell lymphoma (13.2%), and follicular lymphoma (7.3%). Of these patients, 93.4% have at least one comorbidity. The most common comorbidities were hypertension (58.5%), neurological disease (49.4%), diabetes (28.2%), ischemic heart disease (25.5%), cardiac arrhythmia/conduction disorders (24.4%), chronic kidney disease (CKD, 19.2%), heart failure/cardiomyopathy (18.1%), and COPD (12.3%). Overall, 960 patients (34.7%) developed severe outcomes, among which, 847 patients (30.6%) were hospitalized, 214 patients (7.7%) were admitted to the ICU, 201 patients (7.3%) experienced ARI, and 220 patients (8.0%) died. Multivariable logistic regression showed that increased odds of severe outcomes were independently associated with older age (85+ years vs. <65 years; adjusted odds ratio [OR], 2.0; 95% CI, 1.4-2.7), male gender (OR, 1.4; 95% CI, 1.1-1.6), insurance coverage with Medicaid (OR, 1.8; 95% CI, 1.1-2.9) and/or Medicare (vs. commercial only; OR, 1.9; 95% CI, 1.5-2.5), infected during the first quarter (OR, 5.6; 95% CI, 3.4-9.4) or second quarter of 2020 (vs. fourth quarter of 2020; OR, 1.7; 95% CI, 1.4-2.1), having CKD (OR, 1.3; 95% CI, 1.0-1.6), COPD (OR, 1.4; 95% CI, 1.0-1.8), diabetes (OR, 1.3; 95% CI, 1.1-1.6), and receiving active treatment for NHL (OR, 1.4; 95% CI, 1.0-2.0) within 30 days prior to COVID-19 diagnosis (Figure). Conclusions This study demonstrated key demographic and clinical characteristics associated with severe outcomes among COVID-19 patients with mB-cell NHL using one of the largest nationwide databases. Risk factors for severe outcomes identified in the general population, such as older age, male gender, and having certain underlying medical conditions were also identified in this study. In addition, COVID-19 infection occurring earlier in the pandemic and receiving active NHL treatments were associated with severe outcomes. These latter two observations might reflect the improvement in patient management during the latter period of the pandemic and that active mB-cell NHL disease and treatment rendered an increased risk of severe outcomes in COVID-19 patients with mB-cell NHL. These insights highlight the importance of utilizing demographic, clinical and treatment information to estimate the risk for severe outcomes, whereas prospective studies focusing on optimal COVID-19 management are required to identify specific actions that can be taken to improve outcomes of COVID-19 in patients with mB-cell NHL. Figure 1 Figure 1. Disclosures Yue: Joule: Current Employment. Hallett: AbbVie: Current Employment. Liu: AbbVie: Current Employment. Iyengar: AbbVie: Current Employment. Basa: AbbVie: Current Employment. Yang: AbbVie: Current Employment.

All veterinary schools in Australasia require students in the first half of their course to complete work integrated learning (WIL) during vacation time on a range of animal enterprises. This allows students to gain an understanding of how the enterprises function on a day to day basis and compare to the theoretical training that students receive on-campus. The time on-property required is equivalent to 60 days of work with a requirement to visit several enterprises (AVBC, 2016). COVID-19 required immediate cessation of all on-property placements. Given the limited number of holiday weeks available for WIL we developed an on-line experiential program to support student learning. The backbone of the online WIL experience relied on previously developed or developing virtual reality (VR) farm resources; the 4DVirtual Farm and DookieVR (Barber etal, 2016). These resources allow students to visit properties via multiple 360 images through time on a property, allowing virtual travel through time and place to see what happens on an enterprise throughout a year. They also integrate environmental variables and both 360 and standard video to provide access to further information. They are viewable using mobile phones, laptop and desktop systems as well as VR viewers. The basic VR resource allows students to take their own tour around the property however the week of experiential learning was planned to reinforce the students’ ability to see what happens on the individual property throughout the year. This compares to an individual property visit where a student gains more “hands-on” insight for a much more limited timespan of the year, usually 1-2 weeks. The week of synchronous, experiential learning used Zoom as the primary tool to allow communication between staff and students with content managed on the learning management system, Canvas. The standard format for each day involved an initial entire class group session, mostly in didactic information transfer from staff to students and then a mixture of small group, full class or individual tasks. Assessment of content understanding was evaluated on a regular basis using multiple choice questions or word responses using PollEverywhere. The large class group of 100-250 students broke into small virtual rooms of 6 to 8 students. Each day this small student group had a task to complete and submit via Feedback Fruits, which then allocated individual students to provide written feedback on the group report by the next day. Time was allocated for students to review these reports both individually and then to discuss the multiple reports that group members were assessing and submit feedback. In addition, each small group reported on a relevant name to the veterinary industry, either from current or historical times. A short video detailing the link of this name to the veterinary industry was posted to Flipgrid for both staff and other students to review. Student understanding of the week was measured at the commencement and completion of the week using an online multiple choice quiz as well as receiving student feedback by an online survey. This presentation will cover the background, development and design of the week and associated material. References AVBC (2016), Standard 9.3 Extra Mural Studies (EMS or Workplace Learning), page 32, Australasian Veterinary Boards Council, https://avbc.asn.au/wp-content/uploads/documents/public/AVBCStandardsAug2016.pdf Barber S, Hallein E, Shallcross D, Weston J, Jacobson C, Bramley E, Celi P, McGowan M (2016), Final report: Development of 4D farms to improve student learning and safety, Office of Learning and Teaching https://ltr.edu.au/resources/ID12_2365_Barber_Report_2016.pdf

Abstract Abstract 4613 The addition of Rituximab to the combination of Fludarabine and Cyclophosphamide (FCR) for treatment of patients with chronic lymphocytic leukemia (CLL) was recently found by two phase III studies, REACH and CLL8, to be superior to the combination of Fludarabine and Cyclophosphamide alone (Robak T, et al. J Clin Oncol. 2010; 28(10): 1756 – 1765; Hallek M, et al. Lancet 2010; 376(9747): 1164 – 1174). As a result, treatment with FCR was approved for use in Saskatchewan beginning in January of 2010. The characteristic regimen for FCR involves administration of rituximab 375 mg/m2 intravenously (IV) on day 1 followed by fludarabine 25 mg/m2 and cyclophosphamide 250 mg/m2 (FC) administered IV on days 1–3 for a total of 6 treatment cycles at intervals of 28 days. Due to the large geographic area of the province of Saskatchewan, patients are often required to travel extensive distances for appointments and treatment. This has resulted in an adaptation of the FCR regimen to incorporate the administration of oral fludarabine (40 mg/m2) and cyclophosphamide (300 mg/m2) for 3 days following the IV rituximab. In many cases, this has allowed patients to receive Rituximab IV on one day and then to continue the remaining days of treatment with oral therapy from home. This study retrospectively reviewed all patients in Saskatchewan who received FCR treatment for CLL since January 2010. 32 charts were reviewed and examined for the overall efficacy, regimen toxicity and tolerability to the 2 different regimens. Of the 32 patients, 16 patients received an IV regimen and 16 received a regimen that involved receiving FC orally. Of those who received the IV regimen, 2 were female and 14 were male. The average age was 58 (38 – 77). Of those who received the oral regimen, 5 were female and 11 were male. The average age was 62 (48 – 75). Eleven of the 32 patients received FCR as a first line therapy (IV: 6; Oral: 5).The remaining 21 patients received FCR as either a second, third or fourth line therapy (IV: 10, Oral: 11). Results of this study showed that 75% of those who received IV treatment completed 6 cycles, while only 50% of patients who were on an oral regimen were able to complete 6 cycles (OR = 3.00). Infectious complications encountered during treatment were the most common cause for dose reductions for the IV regimen (43.3%) while neutropenia and/or thrombocytopenia accounted for 36.7%. The most common reason for a dose reduction in the oral regimen was neutropenia and/or thrombocytopenia (61.5%). The average number of dose delays for patients receiving both the IV and oral regimen was similar at 1 (0 – 4). Neutropenia and/or thrombocytopenia were the most common reasons for dose delays in both the IV and oral regimens (75% IV, 65% Oral). The oral regimen resulted in hospitalization of 43.8% of patients, while only 12.5% of patients who received the IV regimen required hospitalization at some point during treatment (OR = 5.44). Reasons for hospitalization for those patients on the oral regimen included febrile neutropenia (5), infection (3) and observation (1). The complete remission (CR) and partial remission (PR) rates for the 2 regimens were similar (IV regimen: CR = 56.3%, PR = 25%; Oral regimen: CR = 56.3%, PR = 25%). In conclusion, this retrospective study has shown that an oral regimen of FCR resulted in similar response rates to the IV FCR regimen. However, the oral regimen does result in more hospitalizations and an inability to complete treatment. Whether using an oral FCR regimen remains feasible for treating regions that cover a large geographic territory requires further study. Disclosures: No relevant conflicts of interest to declare.

A magnificent casket in a woman’s grave from the Viking AgeIn 2004 and 2006, Moesgård Museum excavated 21 Viking Age graves – 16 inhumation graves and five cremation graves – at Haldum Church, 20 km northwest of Århus in Eastern Jutland (fig. 1). All the graves with datable finds are from the 10th century; only one example will be presented here.The grave is a simple inhumation burial. The skeleton had completely disappeared and there were no signs of a coffin (fig. 2). About 40 cm from the western end of the grave base lay 16 glass beads scattered around over an area of about 20 x 30 cm. These comprised one red and one orange bead of opaque glass, one bead of white glass and 13 small beads of yellow glass. In the centre of the grave was a slate whetstone (fig. 3). At the eastern end was a concentration of iron fittings, and it soon became clear that these represented the remains of a casket.During excavation of the fittings a well-preserved lock turned up (fig. 4). One end of the lock’s cover plate terminates in a point with concave flared sides, while the other (broad) end divides into two prongs, between which a transverse, semicircular fitting has rusted fast. An iron band has been mounted across the pointed end; this is possibly a repair. The cover plate curves slightly along its length, which means that the lock must have been fitted on to a curved surface. The back of the lock is covered by a quadrangular plate. The distance between front and back plates is 15 mm, showing the thickness of the material within which the lock was fitted. On removing the back plate the lock construction can be seen; this is of well-known Viking Age type. It operates in such a way that the key – after having been placed into the keyhole – is pushed a little to the side so that it squeezes together the two springs of the bolt. The bolt is hereby disengaged and can be pulled back by means of a slide bar, which sits in continuation of the keyhole (fig. 5).The lock bolt is pushed into the above-mentioned, semicircular fitting. The latter comprises two plates separated by a c. 10 mm wide side piece, which gives the fitting the appearance of a small box. Three fittings of this type were found (fig. 6).Further to these components are edge and corner plates. The edge fittings all have the form of narrow, indented borders with small holes between the points. A fragment is shown lowermost on fig. 6. The corner plates have been bent back around the corner joints of the casket and are pointed at both sides.Certain other fittings were at first inexplicable. These mysterious pieces include three triangular fittings with small slide bars on their upper surface and 30 mm long bolts below (fig. 7). There are also fragments of some zip-like iron bands. These are slightly curved along their length and have a roof-shaped cross-section (fig. 8). Finally, there was a robust rivet with a square head, ingeniously worked with inwardly flared, tapered sides and crowned by a small boss.Wood imprints on the back of the fittings show that the casket was made of oak. The imprints were very useful when reconstructing the casket as they clearly show both the longitudinal direction of the wood and the depressions within it. There were imprints from a textile of coarse linen weave on the exterior of some of the edge fittings.It seems that the casket from Haldum had the same construction as the Bamberg casket (figs. 9 and 10). Each of the four sides of the Bamberg casket has, at its centre, a raised semicircular area covered by fittings. The exterior is decorated with a mask and there is a hole on the inside. The bolts of the lid presumably engaged with these holes when the casket was locked. Carved grooves in the wood under the ornamental plates of the lid lead out by way of the holes into the four semicircles. The semicircular fittings of the Haldum casket are, with regard to size and shape, completely identical to the mask fittings seen on the Bamberg casket. One of them is, as mentioned above, rusted to the lock, the bolt of which has been pushed into a hole on its inner surface. Consequently, its function is clear; it is also clear that the casket was locked when placed in the grave.The lid of the Bamberg casket is divided by ornamental bands into four triangular fields (fig. 11). In one of these fields (A), a T-shaped keyhole is apparent, and in continuation of this there is a slot for a slide bar. In the field opposite (C), there is a small hole and each of other fields (B and D) has a partly damaged slide-bar slot. We are so fortunate that the fittings surviving from the Haldum casket include slide bars, bolts and other lock parts that have been lost from the Bamberg casket.It is possible to place the lock and the various fittings from the Haldum casket in a square of the same dimensions as the lid of the Bamberg casket. In the fields created by arranging the zip-shaped fittings to form a diagonal cross, there is space for the lock and the three triangular fittings (fig. 11). The excavation photo in fig. 12 shows the three types of fittings in their original positions. In continuation of the keyhole, the lock has a small slide bar whereby the bolt was pushed into one of the semicircular fittings (side A). The forks of the lock plate extend down on either side of this fitting, demonstrating that there was a central depression in the four sides of lid in order to accommodate the semicircular fittings, as seen on the Bamberg casket. In the triangular fitting, which was located opposite the lock (side C), there is also a small slide bar but no slot in which it could move. Similarly, the wood imprint on the back shows that there was no depression to allow a bolt to be pushed back and forth. On the corresponding side of the lid of the Bamberg casket, the carved depression for the bolt is less marked than on the other sides. On the two remaining triangular fittings from the Haldum casket, the slide bars are located in 15 mm long slots (sides B and D). On the reverse, clear depressions are seen in the wood imprint in which the bolts were slid back and forth (fig. 13). If the fittings are arranged in this way, all the pieces show the same longitudinal direction of the wood imprints on their reverse. This indicates that the casket lid was made from one piece of wood.As is apparent from the carvings on the Bamberg casket, the slide bars of the closing mechanism were located close to the centre of the lid. The hidden grooves for the bolts run from here, under the ornamental plates, and emerge at the edge of the lid. Apparently, the Haldum casket did not have ornamental plates screening the grooves for the bolts. As a consequence, the triangular fittings with the slide bars were placed close to the edge of the lid so that they met the semicircular fittings. In this way it was only necessary to have short grooves for the bolts, and these were covered by the fittings.The way in which the lid and the casket are fitted to one another, together with the absence of hinges, indicates that the lid was loose and was lifted completely off in order to open the box. The bolt opposite the lock (side C) was permanently pushed forwards and was the first to be pushed into the matching semicircular fitting, after which the lid was tilted down into place. After this, the two bolts at the sides (B and D) were extended to keep the lid fastened. Finally, the lock’s bolt was pushed into place and the casket was then locked.By observing the curvature of the striker plate, the triangular fittings, the zip-shaped fittings and some of the edge fittings, which have a curved cross-section, it is possible to reconstruct the shape of the lid (see fig. 10). Its height was c. 45 mm. The rivet must have marked the centre of the lid, corresponding to the cruciform fitting on the lid of the Bamberg casket.The body of the Bamberg casket was assembled by pushing the end surface of one side against the side surface of the next. The wood imprints on the corner plates of the Haldum casket show that the same technique was also used here. It is apparent from these wood imprints, as well as the distance between front and back of the semicircular fittings, that the sides were about 10 mm thick. The wood imprints on the inner side of the semicircular fittings show that the tree rings on the side pieces ran vertically. Had they run horizontally, this would have rendered these curves a weak point.The surviving remains of the Haldum casket show a surprising similarity to the Bamberg casket. There is, however, nothing to indicate that the casket from Haldum was as magnificently decorated, but the now completely vanished oak wood casket may possibly have been decorated with both carvings and paintings. Furthermore, the casket originally had edge fittings greater than 3 mm in width which, in themselves, would also have constituted considerable ornamentation. This fact became evident from construction of the replica (fig. 14). The latter also confirmed the reconstruction of the Haldum casket and its complicated closing mechanism.The Haldum find shows that the Bamberg casket, with its special construction, is not unique, and two further finds kept at Danmark’s National Museum indicate that caskets of this type were perhaps more widespread than previously assumed. One is a cruciform fitting of gilt bronze (fig. 15). The four transepts end in stylised animal heads, and at the centre is a hemispherical raised area. At the centre of the lid of the Bamberg casket there is a cruciform fitting also with animal heads at the ends of the transepts, and in the middle sits a hemispherical rock crystal (fig. 16). The similarity to the former fitting is striking, and it seems likely that the artefact represents a lid fitting for a casket of Bamberg type. The other artefact is a cruciform fitting of sheet bronze with open-work sections between the limbs of the cross and a circular hole at its centre (fig. 17). The fitting is part-finished and of the same type as the first mentioned, but a somewhat different variant. The two fittings were found in an old ford across Halleby Å in Western Zealand near the rich Viking Age settlement at Tissø. They were recovered together with the remains of a tool chest.The grave in which the Haldum casket was found is presumed to be that of a woman because beads and small locked caskets are typical woman’s equipment in Viking Age graves. However, such grave goods have also been found in a few cases in men’s graves. The whetstone gives no indication of the sex of the deceased because this type of artefact was commonly included as grave goods in both men’s and women’s graves. The great similarity of Haldum casket to the Bamberg casket dates the grave to the second half of the 10th century.The style of the Bamberg casket indicates that it was produced in Denmark or Southern Scandinavia. Recently, however, attention has been drawn to the fact that the Mammen style also appears over a wider area. Finds from areas where the Vikings settled outside Scandinavia– from The British Isles to Russia – indicate that craft work in the Mammen style could also have been produced there. The finding of the Haldum casket does, however, add weight to the conclusion that the Bamberg casket was produced in Denmark. This is also the case for the two fittings from Halleby Å if the interpretation presented here is correct. However, whether boxes of this type were produced in one particular place or are the work of one or more travelling craftsmen remains to be ascertained.Jens JeppesenMarianne SchwartzMoesgård Museum

When you exercise and your muscles work harder, your body uses more oxygen and produces more carbon dioxide. To cope with this extra demand, your breathing has to increase from about 15 times a minute when you are resting, up to about 40–60 times a minute during exercise. Your circulation also speeds up to take the oxygen to the muscles so that they can keep moving. Any kind of exertion causes some change in vitals. Some amount of fluctuation in vitals after any kind of exertion occurs in every individual and is considered to be normal. But if there is extreme fluctuation in vitals even after mild or moderate form of exertion, it indicates some kind of abnormality or an increased stress on cardiovascular or respiratory system and needs attention. In any case if the vitals fluctuate during any kind of exertion it needs to be stabilized so that its harmful effects can be avoided. For these breathing exercises have been proven to be very beneficial. There are several types of breathing exercises such as deep breathing, diaphragmatic breathing, pursed lip breathing, etc. The objective of this study is to assess the effect of diaphragmatic breathing exercises on vitals after exertion. In the present study we took 100 subjects randomly from Hallet hospital, Kanpur. Method of data collection is random with study duration of 12 weeks. The paired samples t-test shows significant changes observed i.e., null hypothesis is rejected and alternate hypothesis is accepted and we observed that significant improvement along with effectiveness of Diaphragmatic breathing on controlling vitals amongst post covid individuals.

Abstract Background Previous investigations carried out in ultramafic habitats emphasized the greater importance of site conditions over soil toxic metal content for vegetation composition. Very little is known about the floristic structure of the Southern Carpathian ultramafic grasslands and there is no information on the local environmental drivers of their composition and coenotic features. Here, we aim to fill these knowledge gaps by referring to similar phytocoenoses described in the Balkan Peninsula and central Europe. In particular, we searched for: (i) floristic and ecological patterns supporting the classification and taxonomic assignment of these grasslands, and (ii) simple relationships between serpentine vegetation characteristics and its physiographic environment. A total of 120 phytosociological relevés, of which 52 performed in the Southern Carpathians, were analysed through cluster, ordination and regression procedures. Results Despite some floristic similarities with their Balkan counterparts, the Southern Carpathian ultramafic grasslands were clustered into four distinct groups, which were assigned to as many new syntaxa: Plantago serpentinae–Armerietum halleri, Asplenio serpentini–Achnatheretum calamagrostis, Minuartio frutescentis–Plantaginetum holostei and Sileno saxifragae–Plantaginetum holostei. The latter was best individualised through the occurrence of several Carpathian endemic taxa. The first two ordination axes were significantly related with the terrain slope/presence of xerophilous species and respectively, with site elevation/presence of calcifugous species. The total plant cover showed a unimodal relationship with respect to site elevation. While controlling for the effect of the sampled area, species richness showed a unimodal response to both elevation and slope of the terrain, although their effects were not singular. Conclusions The syntaxonomic distinctiveness of the Southern Carpathian ultramafic grasslands is mainly supported by their overall species composition rather than regional differential species. The main limiting factors driving the composition, cover and species richness of all studied ultramafic grasslands are the water deficit at low elevation and on steep slopes, and the low soil fertility at higher elevations. Our results confirm the previous findings according to which physiographic conditions and, to a lesser extent, soil base nutrients are more important than heavy metal concentrations in structuring the ultramafic vegetation.

Abstract Background In the Brassicaceae, the early stages of compatible pollen-stigma interactions are tightly controlled with early checkpoints regulating pollen adhesion, hydration and germination, and pollen tube entry into the stigmatic surface. However, the early signalling events in the stigma which trigger these compatible interactions remain unknown. Results A set of stigma-expressed pseudokinase genes, termed BRASSIKINs (BKNs), were identified and found to be present in only core Brassicaceae genomes. In Arabidopsis thaliana Col-0, BKN1 displayed stigma-specific expression while the BKN2 gene was expressed in other tissues as well. CRISPR deletion mutations were generated for the two tandemly linked BKNs, and very mild hydration defects were observed for wild-type Col-0 pollen when placed on the bkn1/2 mutant stigmas. In further analyses, the predominant transcript for the stigma-specific BKN1 was found to have a premature stop codon in the Col-0 ecotype, but a survey of the 1001 Arabidopsis genomes uncovered three ecotypes that encoded a full-length BKN1 protein. Furthermore, phylogenetic analyses identified intact BKN1 orthologues in the closely related outcrossing Arabidopsis species, A. lyrata and A. halleri. Finally, the BKN pseudokinases were found to be plasma-membrane localized through the dual lipid modification of myristoylation and palmitoylation, and this localization would be consistent with a role in signaling complexes. Conclusion In this study, we have characterized the novel Brassicaceae-specific family of BKN pseudokinase genes, and examined the function of BKN1 and BKN2 in the context of pollen-stigma interactions in A. thaliana Col-0. Additionally, premature stop codons were identified in the predicted stigma specific BKN1 gene in a number of the 1001 A. thaliana ecotype genomes, and this was in contrast to the out-crossing Arabidopsis species which carried intact copies of BKN1. Thus, understanding the function of BKN1 in other Brassicaceae species will be a key direction for future studies.

This paper begins by presenting and strengthening the labial-velar hypothesis with a novel interpretation of the allophonic distributions of labials and velars in Lusoga (Hyman 2017). The labial-velar hypothesis is an Element Theory proposal that labial (Lab) and dorsal (Dors) consonants are marked by same ‘dark’ place feature |U| (akin to Jakobson & Halle’s (1956) grave). According to this hypothesis, the only difference between Lab and Dors members of any class (say stops) is that Lab is the headed manifestation of |U|, while Dors is the headless version of the same element (Backley & Nasukawa 2009). This, hypothesis however, leads to the strange statement that labial-velar segments such as the labial-velar ‘double’-stop (KP), which would appear to be headless and headed at the same time. What follows is an exploration of the term ‘headedness’ in phonology. Building on the positives of previous approaches, and pairing back the assumptions to the first principles of combination (Merge), I come up with a novel theory of headedness and segment-internal structure: Bare Element Geometry (BEG). The labial-velar hypothesis in light of BEG will then be applied to KP. In order to obtain the right representation for labial-velar ‘double’-stops (KP), it is necessary to precisely understand KP’s distribution and behaviour. Especially because I will reveal some previously unappreciated facts about these segments. In opposition to the classical literature (and all previous accounts known to me), I will conclude that KP is composed of two ordered root nodes, each with a separate place feature. This is based on a detailed typological study and phonological interpretation of attested and unattested nasal + KP assimilation patterns, as well as a novel interpretation of some obscure nasalization facts of KP in Guere (Western Kru). This conclusion that KP has two ordered root nodes is what allows BEG’s model of headedness to interpret a feature as simultaneously headed and headless in different parts of a segment. Moreover, it correctly predicts Cahill (1999)’s empirical observation that KP is universally headed by Labial.

O processo de reparação óssea é controlado por mecanismos moleculares complexos que envolvem fatores sistêmicos e locais. Os adesivos fibrínicos, também conhecidos como selantes de fibrina ou cola de fibrina são produtos não citotóxicos, oriundos de proteínas do plasma humano, que mimetizam a via final da rede de coagulação. Os agentes antifibrinolíticos, tais como o ácido tranexâmico, inibem a fibrinólise e, conseqüentemente, impedem ou diminuem a formação dos produtos de degradação da fibrina e do fibrinogênio. O propósito deste trabalho foi avaliar histologicamente em ratos o efeito do ácido tranexâmico associado à cola de fibrina sobre o reparo ósseo. O experimento utilizou 60 (n=5) ratos machos em grupos assim constituídos: GI:Controle, GII: cola de fibrina, GIII:ácido tranexâmico e GIV: cola de fibrina/ácido tranexâmico. Defeitos ósseos (2.5mm de diâmetro) foram criados nas tíbias direitas. Os animais foram eutanasiados aos 7,14 e 30 dias pós-operatórios e as peças processadas em hematoxilina e eosina. Os resultados mostraram aos 7 dias pós-operatórios cavidade cirúrgica preenchida por tecido conjuntivo denso, rico em fibroblastos, permeado por delicadas trabéculas ósseas neoformadas, em percentual de 70-80% para GI, GII e GIII e 94.8% para GIV. Aos 14 dias pós-operatórios tecido ósseo neoformado foi encontrado entre 75-85% para GI, GII e GIII e em percentual acima de 95% para GIV. Aos 30 dias pós-operatórios GI e GIV apresentaram 95-100% de tecido ósseo maduro; GII e GIII em percentual próximo a 80-90%. Com base nos resultados obtidos e metodologia empregada conclui-se que a associação cola de fibrina/ácido tranexâmico tem ação positiva sobre a reparação óssea.Descritores: Cicatrização; Adesivo Tecidual de Fibrina; Ácido Tranexâmico.ReferênciasAbiraman S, Varma HK, Umashankar PR, John A. Fibrin glue as an osteoinductive protein in a mouse model. 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The paper discusses mobility in the context of displacement. How is the mobile phone appropriated by refugees in immigration detention? What does the mobile phone, and indeed, mobility, signify in an Australian policy landscape of mandatory detention of asylum seekers and formerly prohibited access to mobile phones for detainees inside immigration detention centres? What does this intimate about the perceived dangers of “new” and mobile media? The author’s preliminary research with refugees in Australian immigration detention centres compares policy and practice. Firstly, it interrogates the unwritten policies regulating refugees’ access to media technologies when incarcerated in immigration detention. As there is no written policy on technology access and practices vary across immigration detention centres, the information in this paper has been given by detainees and has not been verified by the management of detention centres. The paper suggests that the utopian promises of mobile media echo those made about cyberspace in the 1990s. Furthermore, the residual effects of such rhetoric have infiltrated government policy in terms of perceiving mobile media as dangerous when adopted by marginalised groups such as refugees. Secondly, the research examines how and why the mobile phone has been adopted by immigration detainees despite their former prohibition. It explores the ways in which refugees practice an imagined mobility through media whilst in detention, and finds that this is critical to sustaining connection with their imagined communities. Why Refugees? In the context of increased forced migration of people due to circumstances such as political instability, war, natural disaster and famine; it is necessary to better understand how refugees mobilise and organise in situations of displacement. As new technologies encourage the capacity for borderlessness, such advantages also have to be contrasted with the potential dangers of spontaneous border crossings. The study of the behaviour and practices of refugees in relation to communication technologies offers an insight into the efficacy of immigration detention policy in filtering movement and interaction, both physical and virtual, between Australia and other countries. Although the study of refugees is a discipline in its own right, there has been minimal examination of how they appropriate technology, particularly that which facilitates and complements their mobility, to maintain connections with their diasporic networks while in situations of displacement. The studies that have been undertaken concentrate on the use of technology by refugees living in the wider community (see Glazebrook, McIver Jr. and Prokosch; Howard and Owens), rather than in the context of detention. In previous research of diasporas within the discipline of Cultural Studies, technology has been regarded as vital to subcultures and minority groups. Technology has been the tool by which such communities respond to their structural conditions (see Cunningham; Hall; Halleck). Such investigations have concentrated on the intersection of class, gender and ethnicity and how they inscribe meanings to specific technologies, which in turn, become intrinsic to the identities of the groups and communities. The research extends the work that has been done within Cultural Studies by similarly focusing on a marginalised group, refugees, and their participation in particular technologies. A review of literature across refugee studies, diaspora studies and technology studies has shown that: The study of technology use by refugees has had minimal investigation The study of diasporas has rarely included refugees The study of communities and communication practices which surround particular technologies has concentrated on groups other than refugees The escalation of issues of asylum and border control in public discourse warrant more knowledge about refugees and their networks of communication beyond the boundaries of detention and Australia The notion of “networks” refers to people, technologies, processes and practices that form the relationships between refugees in institutionalised immigration detention and the outside world. The Australian Immigration Detention Context Between 1992 and 1994, Australian law moved from permitting (but not enforcing) limited detention of asylum seekers, to a blanket policy of mandatory detention (HREOC) which, at one point, had up to 12,000 individuals in detention (Castan Centre for Human Rights Law). The detention context is particularly relevant to Australia, because its policy of mandatory detention means that refugees have restricted contact with the world outside of the detention centre. In 2005, the Migration Amendment (Detention Arrangements) Bill allowed detained families with children to live in community detention, that is, in residential accommodation outside of an immigration detention centre. Although community detention carries with it specific conditions, families are unaccompanied and have more freedom of movement. This paper discusses the author’s preliminary work with refugees in immigration detention, prior to the introduction of community detention. The research sought to investigate how asylum seekers use technology to sustain connections with their virtual communities in situations of displacement. Specifically, it explored how technology is appropriated to mediate communication in the context of institutionalised detention. The key research questions addressed by the research were: what kinds of technologies are available to refugees? How are these used? How are their benefits and limitations perceived? What, if any, kinds of social networks surround these technologies? How are relationships of power surrounding these technologies negotiated? Can technology assist refugees in sustaining connections with their communities of choice and reducing their sense of isolation? Can technology play a role in reducing the well-documented effects of this incarceration by providing mediated social interaction? What are the implications for policy, especially in relation to permitted technologies and surveillance of communication practices? Access to informants was gained by working with a refugee community advocacy group, which has established links with refugees in detention and experience in dealing with the management of detention centres. One such group is ChilOut, which organises visitor programs to immigration detention centres. This affiliation was important in gaining access to, and trust of, detainees who were willing to participate in the research. It presented opportunities to interact with detainees on a social basis. Semi-structured interviews with the research subjects were conducted to ascertain the strategies and resources currently utilised to counter the effects of mandatory detention. In 2005, detainees had access to a range of technology which can be broadly termed “old media”, while access to “new media” – such as the Internet and mobile phones – are prohibited. At the time of printing, detainees reported that mobile phones without cameras were only recently permitted. Detainees have access to pay phones inside the centre. Visitors are allowed to give detainees phone cards so they can use the pay phones without charge or the need for change. In addition to pay phones, detainees are provided with access to a fax and photocopier, which are generally used to liaise with and send relevant documentation to lawyers. There is distrust of using the fax machine at the detention centre because it is in a management office area and the detainees require permission to use it. It means the guards can read the faxes that are sent, as well as those that are received before notifying the detainees that they have received one. Detainees also have television, videos, DVDs and newspapers, so there is the possibility of feeling like part of an imagined community (Anderson) through these media. There are computers available, but no Internet access. Some of the children load computer games on them to play, others have Playstation in their rooms. It is noteworthy that the only technology to which detainees have access and which facilitates real-time person-to-person interaction is the telephone. The phone offers the opportunity for direct contact with the outside world without the visual and other sensory realities of detention. The telephone is able to mask the extent of imprisonment as it does not show the barbed razor wire surrounding the compound. Yet detainees were not permitted to have mobile phones for a long time. Thus, the key question remains: why were they deprived of access to mobile phones while allowed access to pay phones and landlines? What does this suggest about the perceived dangers of mobile media and the resonance of last century’s techno-utopian discourses? Given that detainees were only given access to “old media”, it seems that this tired but resolutely upbeat rhetoric about new technology which celebrates it as inherently liberating actually inflected policies determining the kinds of technologies to which detainees have access. It confirms the pessimistic assertions of media theorists such as Schiller and Mosco, that new technologies further alienate disadvantaged groups. As the Australian government attempts to regulate the physical movement of people across its borders, mantras of the dot.com era such as “everyone is a free agent” (Kumar 77) appear to undermine this agenda. The assumptions of liberty and democracy embedded in this “free agency” are implicit in policies that denied refugees access to “new media” such as the Internet and mobile phones. The “liberating” nature of such technology was regarded as unsafe in the hands of refugees, whose freedom of movement is institutionally contained by the Australian government through mandatory detention. The physical movement of refugees, as well as the agency and freedom with which they can claim asylum in a country, is actively discouraged through immigration detention policy and limitations on access to technology. The promise of self-expression afforded by mobile media seemed antithetical to the prejudicial administration of refugees, which is premised upon a distrust of their claims of identity and asylum. Subsequently, their use of mobile technology was also assumed to be suspect and therefore had to be restricted. Detained refugees serve as a reminder of the parameters of upbeat discourses about new technology. That is, the utopian possibilities of mobile media appear to be conditional such that its “power” can only be entrusted to certain groups. In policy terms, the mobile phone is a rich site of signification. Not only does the technology itself imply a way of being (that is free, mobile, always accessible and always able to access), but it also connotes an ideal type of user, one that is appropriate and deserving of such technology. It seems that refugees are not entitled to their mobility and, therefore, do not have rights to media that is considered to facilitate such mobility, in spite of their detention. Furthermore, there is a suggested dichotomy in the government’s classification of the technologies to which refugees have access. The fact of detention means refugees are surrounded by technology, held captive by it and are inevitably in close proximity to it. It is technology which is seen as antithetical to mobility and therefore could be described as “static”: phones, faxes, photocopiers, television, video – all of which may be characterised as “old media”. The binary opposite of such technology is that which can be regarded as mobile or new or interactive media; that which resonates with the residual effects of 1990s techno-utopian rhetoric; and could be considered as threatening in the hands of those who have physically made unauthorised border crossings. However, prior investigations of “mobile” technologies, demonstrates that such dualisms are flawed as the lowest technologies also have the capacity to facilitate mobility. Examples include Paul Gilroy’s work on the Black Atlantic, which notes that books and records have been vital in carrying oppositional ideologies and philosophies across the black diaspora. Within Asian diasporas, the exchange of video letters and taped Bollywood movies have been interpreted as forms of localised challenges to the centralised power of the broadcast media industries (Ang; Gillespie). These economies of exchange as facilitated by older forms of mobile media have been studied in relation to issues of migration and marginalisation. Given that refugees are also affected by such issues, their mobile media practices are a sobering reminder that mobility is not necessarily hi-tech nor confined to the realms of the affluent, educated and socio-economically advantaged. Rather, mobility can be a tenuous state of being displaced and itinerant, with technology adopted to manage and adapt to its challenges. The Mobile Media Practices of Detained Refugees The initial findings from the fieldwork indicate that for refugees, the mobile phone is not a technology of choice but instead, a technology of necessity and survival. Every technology that is available to them is used to sustain connection to their localized and globalised networks. The restriction to their physical movement of detainees is compensated through use of technology which allows any sort of interaction and communication. Being part of a technologically-mediated community appears to minimise the marginalisation and isolation they experience. Such feelings of dislocation have been well-documented in studies of the impact of incarceration on the mental health of refugees (see Mares and Jureidini; RANZCP; Hodes). It seems that the telephone and fax are the mainstays of their communication networks. However, such technologies are closely monitored, as landline phone calls can be traced or even tapped, and faxes have to be sent from an office manned by guards. An experienced visitor to detention centres commented that “most” detainees had mobile phones and when they were contraband, guards knew about them but generally ignored their use by detainees. Only mobile phones offer the potential for communication to be free from the surveillance by detention centres staff. The ways in which mobile phones are used by detainees is decidedly lo-tech, for example, for communication with family where use of a landline is impractical. One of the detainees said that he speaks to his wife and children on the centre pay phone every few days. However, the call costs are expensive as his family only has a mobile phone, not a landline, at their place of residence. For them to call him is also expensive and awkward, because they have to call the pay phone and if somebody answers, they have then to locate him somewhere within the compound. Thus, the connections between the detainees and their loved ones are very fragile in that they are almost totally dependent on the phone to maintain these relationships. In this instance, the mobile phone offers another means for managing the tenuous nature of these ties. The mobile phone, particularly SMS technology, offers a suitable alternative as the detainee can communicate with his family cheaply and quickly. It compensates for the constraints of the pay phone. The informal interactions afforded by the mobile phone also extend beyond family members of detainees to their supporters and advocates. Likewise, the mobile phone complements the communication practices facilitated through permitted technologies. For example, when detainees are liaising with the Department of Immigration (DIMIA), they will ask advice from the regular visitors to the immigration detention centre who come from an array of organizations such as churches, refugee advocacy groups, law firms and health organizations. Visitors generally offer whatever assistance they can by obtaining necessary forms from the department, searching the Internet, undertaking letter writing campaigns, and lobbying government ministers. Something worked in amongst all the network activity that took place over the course of this week. As promised to the family, I scoured the DIMIA web site for a form for applying under Section 417. While there didn’t seem to be an official form, I used the opportunity to research the section of the Migration Act. Googling turned up a 12 page “guide to section 417 applications” written by a barrister, which I printed out and faxed to them. So as to ensure that the family received the fax, I SMS-ed them to let them know a fax was on its way and how many pages to expect. They responded to me by fax, saying that they had been notified that they too were going to be released into community detention in the coming weeks. (Extract from fieldwork diary) The mobile phone serves the function of anticipating and verifying communications which may potentially be surveilled by staff of detention centres. Where detainees may not trust that they are being given all the letters or faxes that have been sent to them, the mobile phone enables a degree of privacy so that they at least know what to expect from their correspondents. Furthermore, it provides the opportunity for detainees to speak about matters related to their case for asylum that are regarded as too sensitive to risk being discussed in a public place such as on the centre pay phone. Often this involves seeking assistance with their application for asylum. He rang T on the centre pay phone and said that he would like to speak with me, but did not have my number. He didn’t have a pen and paper to jot down my details at the time, so he gave T his mobile number and asked her to pass it onto me, so I could ring him on it. When I rang, he had returned to his room where he could talk freely. He told me about the visit from the Commonwealth Ombudsman, who undertook to look into his case over the next couple of weeks. We talked about what would assist the Ombudsman in reviewing the case. I said I would write a letter or email in the first instance, and if he wanted other letters of support, I could circulate details of his case on the ChilOut newsletter. He said he didn’t want publicity at this stage. I offered to fax him a copy of my email, but he preferred that I give it to him in person as the fax machine in the office was too public and any documents received could be read. Again, the mobile seems to be the most appropriate technology for coordinating and organising privately away from centre surveillance… (Extract from fieldwork diary) Fear of breaches of confidentiality form only part of detainees’ desire for privacy from detention centre staff. There is also a need for private space away from other detainees as their imprisonment necessitates the constant use of communal facilities such as the pay phone. In addition to being used for its capacity for private communication, the mobile phone was also exploited as a broadcast technology by detained refugees. Text messages proved an effective way of providing brief updates to family and friends about the status of their case: 20 September 200510:24:07 Hi Linda. I am fine thank u. not news yet, I think they’ll come to see me soon, if I got news, I’ll let u know. Wish u have a good time. 15 October 200516:31:49 HI Linda, I was interview by Ombudsman yesterday, we talked about one hour and a half, it sound good…Thank u for yr concern 25 December 200520:26:54 Hi Linda. I am still in [detention centre]. No any news from Ombudsman, may be early next year. I am fine here, thanks. Tuesday 17 October 200613:44:41 Hi Linda…I transferd to [community] housing. Its much better here. How a u? takecare ur health, thanks. Thursday 16 November 200618:46:23 HI There is a good news to let u know I got the decision from that I won the FC case. Thus, for detained refugees, the mobile phone has been adopted for simple, lo-tech use. None of the respondents indicated a desire for a camera function on their mobile phones. However, one detainee did suggest that she would like to use a webcam to see and hear her child in China, whom she has not seen in eight years. While she did use the Internet for this purpose when she was on the “outside”, now she can only rely on weekly telephone conversations made from inside the detention centre. Conclusion What happens when technology is placed in the hands of those for whom it was never meant? It makes explicit what is often implied in studies of adoption of new technology, that the “utopian promise” is confined to a narrow socio-economic demographic: the advantaged, the affluent and the educated. Those who fall outside these perimeters are perceived as undeserving and untrustworthy of such technology. This is exemplified in the Australian government’s policy to deny refugees access to “new” and mobile media whilst being compulsorily detained. The decision to withhold mobile technology from mobile communities who are not so materially privileged is not only ironic but unwarranted in light of the empirical data. This has since been acknowledged by allowing detainees use of mobile phones. The mobile phone practices of detained refugees show that it is being used as a complementary and alternative technology, that is, to compensate for the inadequacies of the communication media allowed by detention centres. The mobile phone is exploited for the functions that permitted technologies do not offer: firstly, the ability to communicate with friends and family more immediately and effectively; secondly, the capacity to communicate privately with less probability of surveillance; thirdly, the opportunity to broadcast content one to many. In such communications, use of the mobile phone is simple and lo-tech: it is deployed for straightforward (but improved) interaction with detainees’ imagined communities which would otherwise be possible anyway through the “old” media technologies provided in detention. In practice, there was no evidence of the use of the hi-tech functions of mobile phones; nor was there any indication, as implied by policy, of the possible dangers that may ensue if such features of mobile media were available to detained refugees. Potentially, the research can impact on immigration detention policy, particularly in terms of reviewing the conditions under which technology is made available to refugees in institutionalised detention contexts. However, further research is required, especially a comparison of the former prohibited use of mobile media in immigration detention centres with the permitted use of these in community immigration detention. References Anderson, Benedict. Imagined Communities. 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APA Style Leung, L. (Mar. 2007) "Mobility and Displacement: Refugees' Mobile Media Practices in Immigration Detention," M/C Journal, 10(1). Retrieved echo date('d M. Y'); ?> from <http://journal.media-culture.org.au/0703/10-leung.php>.